Meta-analysis of structural brain abnormalities associated with stimulant drug dependence and neuroimaging of addiction vulnerability and resilience.
paper
Cited
Public
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- Authors
- Ersche, Karen D; Williams, Guy B; Robbins, Trevor W; Bullmore, Edward T
- Year
- 2013
- Journal
- Current opinion in neurobiology
- PMID
- 23523373
- DOI
- 10.1016/j.conb.2013.02.017
Since the first study in stimulant-dependent individuals using structural MRI was published fifteen years ago, much evidence has accumulated on brain abnormalities associated with stimulant drug dependence. Here we conducted a voxel-based morphometry meta-analysis of published MRI data in stimulant-dependent individuals to clarify the most robust abnormalities underlying the disorder. We found that neuroimaging studies in stimulant-dependent individuals consistently report a gray matter decline in the prefrontal cortex regions associated with self-regulation and self-awareness. One of the next key questions that neuroimaging research today needs to address is the question of causality, namely to what extent these brain abnormalities are caused by the toxic effects of drug exposure, or the possibility that these may have predated drug-taking and even predisposed individuals for the development of drug dependence. Although the question of causality has not yet been answered completely, there has been significant progress made to date.
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| Title | Year | PMID |
|---|---|---|
| Genome-wide association study of stimulant dependence. | 2021 | 34226506 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
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| Patterns of structural brain differences in cocaine use disorder: Integrating multilevel frequentist, Bayesian, and coordinate-based meta-analyses. | Bittencourt AML et al. | — | 2026 | → |
| Stimulant use disorder indicative of increased serum soluble intercellular adhesion molecule-1 concentrations with altered brain reward and interoceptive processing. | Burrows K et al. | — | 2026 | → |
| Distinct Behavioral Profiles and Neuronal Correlates of Heroin Vulnerability Versus Resiliency in a Multi-Symptomatic Model of Heroin Use Disorder in Rats. | Kuhn BN et al. | — | 2025 | → |
| Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats. | Kuhn BN et al. | — | 2025 | → |
| Grey Matter Volume in Substance Use: A Preregistered, Dimensional Approach to Disentangle Substance Use and Disorder Severity. | Schwarz K et al. | — | 2025 | → |
| New Approaches to Addiction Treatment Based on Learning and Memory. | Bach P et al. | — | 2025 | → |
| Opioid use and abuse in adolescents and young adults; dealing with science, laws and ethics: Charming the COBRAS. | Greydanus DE et al. | — | 2025 | → |
| Sex differences in dorsal striatal volume and interest in quitting smoking. | Huang S et al. | — | 2025 | → |
| Similarities and Differences in Neuroimaging. | Lin X et al. | — | 2025 | → |
| Striatal brain volume linked to severity of substance use in high-risk incarcerated youth. | Anderson NE et al. | — | 2025 | → |
| Structural Cerebellar and Lateral Frontoparietal Networks are altered in CUD: An SBM Analysis. | Lacomba-Arnau E et al. | — | 2025 | → |
| The Diagnosis and Treatment of Stimulant-Related Emergencies. | Fries A et al. | — | 2025 | → |
| Boosting Psychotherapy With Noninvasive Brain Stimulation: The Whys and Wherefores of Modulating Neural Plasticity to Promote Therapeutic Change. | Saccenti D et al. | — | 2024 | → |
| Brain changes following mindfulness: Reduced caudate volume is associated with decreased positive urgency. | Mas-Cuesta L et al. | — | 2024 | → |
| Neurobehavioral Precursors of Compulsive Cocaine Seeking in Dual Frontostriatal Circuits. | Jones JA et al. | — | 2024 | → |
| Prefrontal-Limbic Circuitry Is Associated With Reward Sensitivity in Nonhuman Primates. | Hur KH et al. | — | 2024 | → |
| Abnormal neuroanatomical patterns as potential diagnostic biomarkers for cocaine use disorder. | Xu H et al. | — | 2023 | → |
| Adaptation in Young Military Recruits: Protocol for the Advancing Research on Mechanisms of Resilience (ARMOR) Prospective Longitudinal Study. | Polusny MA et al. | — | 2023 | → |
| A Longitudinal Investigation of Blood Neurofilament Light Chain Levels in Chronic Cocaine Users. | Bavato F et al. | — | 2023 | → |
| Brain structural alterations in internet gaming disorder: Focus on the mesocorticolimbic dopaminergic system. | Tian MY et al. | — | 2023 | → |
| Cocaine Destroys Gray Matter Brain Cells and Accelerates Brain Aging. | Beheshti I | — | 2023 | → |
| Common and distinct fronto-striatal volumetric changes in heroin and cocaine use disorders. | Ceceli AO et al. | — | 2023 | → |
| Computationally Informed Interventions for Targeting Compulsive Behaviors. | Kahnt T | — | 2023 | → |
| Lower cortical thickness and increased brain aging in adults with cocaine use disorder. | Schinz D et al. | — | 2023 | → |
| Pathways to the persistence of drug use despite its adverse consequences. | McNally GP et al. | — | 2023 | → |
| Residual deficits in functional brain activity after chronic cocaine self-administration in rhesus monkeys. | Porrino LJ et al. | — | 2023 | → |
| Assessment of brain connectome alterations in male chronic smokers using structural and generalized q-sampling MRI. | Weng JC et al. | — | 2022 | → |
| Brain tract structure predicts relapse to stimulant drug use. | Tisdall L et al. | — | 2022 | → |
| Common and distinct cortico-striatal volumetric changes in cocaine and heroin use disorder | Ceceli AO et al. | — | 2022 | — |
| Convergent gray matter alterations across drugs of abuse and network-level implications: A meta-analysis of structural MRI studies. | Hill-Bowen LD et al. | — | 2022 | → |
| Differences in orexin-A level in the functional brain network of HUD patients undergoing harm reduction therapy. | You WR et al. | — | 2022 | → |
| Driving under the influence of drugs: Correlation between blood psychoactive drug concentrations and cognitive impairment. A narrative review taking into account forensic issues. | Blandino A et al. | — | 2022 | → |
| Dynamic modulation of inhibition ability following repeated exposures to morphine in macaque monkey. | Ghasemian S et al. | — | 2022 | → |
| Effects of OPRM1 and DRD2 on brain structure in drug-naïve adolescents: Genetic and neural vulnerabilities to substance use. | Picci G et al. | — | 2022 | → |
| In- and Out-Group Effects on Social Perception and Empathy in Cocaine Use Disorder. | Aue T et al. | — | 2022 | → |
| Morphometric similarity deviations in stimulant use disorder point towards abnormal brain ageing. | Zhukovsky P et al. | — | 2022 | → |
| New directions in modelling dysregulated reward seeking for food and drugs. | Brown RM et al. | — | 2022 | → |
| Relationship between Depression and Cognitive Inhibition in Men with Heroin or Methamphetamine Use Disorder in First-Time Mandatory Detoxification. | Xin Y et al. | — | 2022 | → |
| Structural and functional brain recovery in individuals with substance use disorders during abstinence: A review of longitudinal neuroimaging studies. | Parvaz MA et al. | — | 2022 | → |
| The impact of levamisole and alcohol on white matter microstructure in adult chronic cocaine users. | Michels L et al. | — | 2022 | → |
| The neurobiology of drug addiction: cross-species insights into the dysfunction and recovery of the prefrontal cortex. | Ceceli AO et al. | — | 2022 | → |
| A CNN-Based Autoencoder and Machine Learning Model for Identifying Betel-Quid Chewers Using Functional MRI Features. | Ho MC et al. | — | 2021 | → |
| Addiction as a brain disease revised: why it still matters, and the need for consilience. | Heilig M et al. | — | 2021 | → |
| A prospective longitudinal study shows putamen volume is associated with moderate amphetamine use and resultant cognitive impairments. | Kendrick KM et al. | — | 2021 | → |
| Bidirectional causality between addiction and cognitive deficits. | Melugin PR et al. | — | 2021 | → |
| Bidirectional role of acupuncture in the treatment of drug addiction. | Lee MY et al. | — | 2021 | → |
| Brain micro-architecture and disinhibition: a latent phenotyping study across 33 impulsive and compulsive behaviours. | Romero-Garcia R et al. | — | 2021 | → |
| Circuit selectivity in drug versus natural reward seeking behaviors. | Nall RW et al. | — | 2021 | → |
| Common abnormality of gray matter integrity in substance use disorder and obsessive-compulsive disorder: A comparative voxel-based meta-analysis. | Klugah-Brown B et al. | — | 2021 | → |
| Cortical thickness and subcortical volume abnormalities in male crack-cocaine users. | Bittencourt AML et al. | — | 2021 | → |
| Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics. | Le TM et al. | — | 2021 | → |
| Genome-wide association study of stimulant dependence. | Cox J et al. | — | 2021 | → |
| Long-term Anabolic-Androgenic Steroid Use Is Associated With Deviant Brain Aging. | Bjørnebekk A et al. | — | 2021 | → |
| Long-Term Cocaine Self-administration Produces Structural Brain Changes That Correlate With Altered Cognition. | Jedema HP et al. | — | 2021 | → |
| Neurocognition in stimulant addiction: commentary on Kendrick et al (2021). | Robbins TW | — | 2021 | → |
| Neurocognition in stimulant addiction: reply to Robbins (2021). | Becker B | — | 2021 | → |
| Structural Brain Correlates of the Externalizing Spectrum in Young Adults. | Delfin C et al. | — | 2021 | → |
| Use of levamisole-adulterated cocaine is associated with increased load of white matter lesions. | Conrad F et al. | — | 2021 | → |
| Anticipation of monetary reward in amygdala, insula, caudate are predictors of pleasure sensitivity to d-Amphetamine administration. | Langenecker SA et al. | — | 2020 | → |
| Network failures: When incentives trigger impulsive responses. | Zhukovsky P et al. | — | 2020 | → |
| PET Hypometabolism of the Prefrontal-Cingulate Cortices in Internet Gaming Disorder. | Kim SK et al. | — | 2020 | → |
| Pinpointing Neural Correlates of Attachment in Poly-Drug Use: A Diffusion Tensor Imaging Study. | Fuchshuber J et al. | — | 2020 | → |
| Shared gray matter alterations in individuals with diverse behavioral addictions: A voxel-wise meta-analysis. | Qin K et al. | — | 2020 | → |
| The anterior insular cortex in the rat exerts an inhibitory influence over the loss of control of heroin intake and subsequent propensity to relapse. | Joshi DD et al. | — | 2020 | → |
| The transition to compulsion in addiction. | Lüscher C et al. | — | 2020 | → |
| Ultrahigh-resolution MRI reveals structural brain differences in serotonin transporter knockout rats after sucrose and cocaine self-administration. | Karel P et al. | — | 2020 | → |
| Altered orbitofrontal sulcogyral patterns in gambling disorder: a multicenter study. | Li Y et al. | — | 2019 | → |
| Altered white matter connectivity in young people exposed to childhood abuse: a tract-based spatial statistics (TBSS) and tractography study | Lim L et al. | — | 2019 | → |
| Cannabis and mental illness: a review. | Lowe DJE et al. | — | 2019 | → |
| Decreased brain connectivity in smoking contrasts with increased connectivity in drinking. | Cheng W et al. | — | 2019 | → |
| Efficacy of Pharmacological Interventions in Targeting Decision-Making Impairments across Substance and Behavioral Addictions. | Chamberlain SR et al. | — | 2019 | → |
| HIV infection and age effects on striatal structure are additive. | O'Connor EE et al. | — | 2019 | → |
| Is treated HIV infection still toxic to the brain? | O'Connor E et al. | — | 2019 | → |
| Longitudinal changes in cocaine intake and cognition are linked to cortical thickness adaptations in cocaine users. | Hirsiger S et al. | — | 2019 | → |
| Neural mechanisms of extinguishing drug and pleasant cue associations in human addiction: role of the VMPFC. | Konova AB et al. | — | 2019 | → |
| Neural response to betel quid cues in chewers: a functional magnetic resonance imaging study. | Ho MC et al. | — | 2019 | → |
| Neuroimaging of reward mechanisms in Gambling disorder: an integrative review. | Clark L et al. | — | 2019 | → |
| Neuroimaging reward, craving, learning, and cognitive control in substance use disorders: review and implications for treatment. | Tanabe J et al. | — | 2019 | → |
| Opposing roles for amygdala and vmPFC in the return of appetitive conditioned responses in humans. | Ebrahimi C et al. | — | 2019 | → |
| Orbitofrontal gray matter deficits as marker of Internet gaming disorder: converging evidence from a cross-sectional and prospective longitudinal design. | Zhou F et al. | — | 2019 | → |
| Risk, reversibility and resilience of brain circuitries linked to opioid dependence: A diffusion tensor imaging study of actively opioid-using subjects and three comparison groups. | Ghosh A et al. | — | 2019 | → |
| Structural brain characteristics of anabolic-androgenic steroid dependence in men. | Hauger LE et al. | — | 2019 | → |
| The Insula: A Brain Stimulation Target for the Treatment of Addiction. | Ibrahim C et al. | — | 2019 | → |
| Addictive behaviour in experimental animals: prospects for translation. | Everitt BJ et al. | — | 2018 | → |
| Brain substrates of early (4h) cigarette abstinence: Identification of treatment targets. | Franklin TR et al. | — | 2018 | → |
| Cognitive and neuroanatomical impairments associated with chronic exposure to levamisole-contaminated cocaine. | Vonmoos M et al. | — | 2018 | → |
| Examining neural correlates of psychopathology using a lesion-based approach. | Calamia M et al. | — | 2018 | → |
| Internet Communication Disorder and the structure of the human brain: initial insights on WeChat addiction. | Montag C et al. | — | 2018 | → |
| In vivo structural imaging in rats reveals neuroanatomical correlates of behavioral sub-dimensions of cocaine addiction. | Cannella N et al. | — | 2018 | → |
| Mapping brain functional alterations in betel-quid chewers using resting-state fMRI and network analysis. | Weng JC et al. | — | 2018 | → |
| Metabolic alterations in the anterior cingulate cortex and related cognitive deficits in late adolescent methamphetamine users. | Kim JE et al. | — | 2018 | → |
| Structural change of thalamus in cirrhotic patients with or without minimal hepatic encephalopathy and the relationship between thalamus volume and clinical indexes related to cirrhosis. | Lu CQ et al. | — | 2018 | → |
| Toward biomarkers of the addicted human brain: Using neuroimaging to predict relapse and sustained abstinence in substance use disorder. | Moeller SJ et al. | — | 2018 | → |
| Comparative Multimodal Meta-analysis of Structural and Functional Brain Abnormalities in Autism Spectrum Disorder and Obsessive-Compulsive Disorder. | Carlisi CO et al. | — | 2017 | → |
| Evaluation of structural connectivity changes in betel-quid chewers using generalized q-sampling MRI. | Weng JC et al. | — | 2017 | → |
| Fractionating impulsivity: neuropsychiatric implications. | Dalley JW et al. | — | 2017 | → |
| Heavy Drinking in College Students Is Associated with Accelerated Gray Matter Volumetric Decline over a 2 Year Period. | Meda SA et al. | — | 2017 | → |
| Implications of the Hierarchical Structure of Psychopathology for Psychiatric Neuroimaging. | Zald DH et al. | — | 2017 | → |
| Meta-analysis reveals a lack of sexual dimorphism in human amygdala volume. | Marwha D et al. | — | 2017 | → |
| Microstructures in striato-thalamo-orbitofrontal circuit in methamphetamine users. | Li Y et al. | — | 2017 | → |
| Neural correlates of impaired self-awareness of apathy, disinhibition and dysexecutive deficits in cocaine-dependent individuals. | Moreno-López L et al. | — | 2017 | → |
| Patterns of white matter microstructure in individuals at ultra-high-risk for psychosis: associations to level of functioning and clinical symptoms. | Krakauer K et al. | — | 2017 | → |
| Similarities and Differences in Neuroimaging. | Sun YK et al. | — | 2017 | → |
| The effect of crack cocaine addiction and age on the microstructure and morphology of the human striatum and thalamus using shape analysis and fast diffusion kurtosis imaging. | Garza-Villarreal EA et al. | — | 2017 | → |
| The neurobiology of addiction: the perspective from magnetic resonance imaging present and future. | Suckling J et al. | — | 2017 | → |
| A debate on working memory and cognitive control: can we learn about the treatment of substance use disorders from the neural correlates of anorexia nervosa? | Brooks SJ | — | 2016 | → |
| Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On. | Everitt BJ et al. | — | 2016 | → |
| Emotional self-control and dysregulation: A dual-process analysis of pathways to externalizing/internalizing symptomatology and positive well-being in younger adolescents. | Wills TA et al. | — | 2016 | → |
| Individual Differences in Cognitive Control Circuit Anatomy Link Sensation Seeking, Impulsivity, and Substance Use. | Holmes AJ et al. | — | 2016 | → |
| In search of predictive endophenotypes in addiction: insights from preclinical research. | Belin D et al. | — | 2016 | → |
| Metacognitive impairment in active cocaine use disorder is associated with individual differences in brain structure. | Moeller SJ et al. | — | 2016 | → |
| Reward-Based Spatial Learning in Teens With Bulimia Nervosa. | Cyr M et al. | — | 2016 | → |
| Sex differences in impulsive and compulsive behaviors: a focus on drug addiction. | Fattore L et al. | — | 2016 | → |
| Shared neural basis of social and non-social reward deficits in chronic cocaine users. | Tobler PN et al. | — | 2016 | → |
| Spatial short-term memory is impaired in dependent betel quid chewers. | Chiu MC et al. | — | 2016 | → |
| Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users. | Willi TS et al. | — | 2016 | → |
| Volumetric brain abnormalities in polysubstance use disorder patients. | Noyan CO et al. | — | 2016 | → |
| Alcohol use disorder with and without stimulant use: brain morphometry and its associations with cigarette smoking, cognition, and inhibitory control. | Pennington DL et al. | — | 2015 | → |
| Altered regional brain volumes in elderly carriers of a risk variant for drug abuse in the dopamine D2 receptor gene (DRD2). | Roussotte FF et al. | — | 2015 | → |
| Bridging the gap between the neurocognitive lab and the addiction clinic. | Franken IHA et al. | — | 2015 | → |
| Clinical neuroscience of addiction: similarities and differences between alcohol and other drugs. | Karoly HC et al. | — | 2015 | → |
| Depression and executive dysfunction contribute to a metamemory deficit among individuals with methamphetamine use disorders. | Casaletto KB et al. | — | 2015 | → |
| Fronto-striatal circuits in response-inhibition: Relevance to addiction. | Morein-Zamir S et al. | — | 2015 | → |
| Gray matter abnormalities in cocaine versus methamphetamine-dependent patients: a neuroimaging meta-analysis. | Hall MG et al. | — | 2015 | → |
| Identification of a common neurobiological substrate for mental illness. | Goodkind M et al. | — | 2015 | → |
| Impulsivity relates to striatal gray matter volumes in humans: evidence from a delay discounting paradigm. | Tschernegg M et al. | — | 2015 | → |
| Investigating Maternal Brain Structure and its Relationship to Substance Use and Motivational Systems. | Rutherford HJ et al. | — | 2015 | → |
| Sex Differences in Gray Matter Changes and Brain-Behavior Relationships in Patients with Stimulant Dependence. | Regner MF et al. | — | 2015 | → |
| Smaller amygdala and medial prefrontal cortex predict escalating stimulant use. | Becker B et al. | — | 2015 | → |
| The brain disease model of addiction: is it supported by the evidence and has it delivered on its promises? | Hall W et al. | — | 2015 | → |
| White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection. | Tang VM et al. | — | 2015 | → |
| Cerebral gray matter volumes and low-frequency fluctuation of BOLD signals in cocaine dependence: duration of use and gender difference. | Ide JS et al. | — | 2014 | → |
| Contributions of the insula to cognition and emotion. | Gasquoine PG | — | 2014 | → |
| Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories--indications for novel treatments of addiction. | Everitt BJ | — | 2014 | → |
| Executive cognitive dysfunction and ADHD in cocaine dependence: searching for a common cognitive endophenotype for addictive disorders. | Cunha PJ et al. | — | 2013 | → |
| Harm reduction: compassionate care of persons with addictions. | Bartlett R et al. | — | 2013 | → |