LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants.
paper
Cited
Public
Unavailable
- Authors
- Machiela, Mitchell J; Chanock, Stephen J
- Year
- 2015
- Journal
- Bioinformatics (Oxford, England)
- PMID
- 26139635
- DOI
- 10.1093/bioinformatics/btv402
- PMCID
- PMC4626747
UNLABELLED: Assessing linkage disequilibrium (LD) across ancestral populations is a powerful approach for investigating population-specific genetic structure as well as functionally mapping regions of disease susceptibility. Here, we present LDlink, a web-based collection of bioinformatic modules that query single nucleotide polymorphisms (SNPs) in population groups of interest to generate haplotype tables and interactive plots. Modules are designed with an emphasis on ease of use, query flexibility, and interactive visualization of results. Phase 3 haplotype data from the 1000 Genomes Project are referenced for calculating pairwise metrics of LD, searching for proxies in high LD, and enumerating all observed haplotypes. LDlink is tailored for investigators interested in mapping common and uncommon disease susceptibility loci by focusing on output linking correlated alleles and highlighting putative functional variants. AVAILABILITY AND IMPLEMENTATION: LDlink is a free and publically available web tool which can be accessed at http://analysistools.nci.nih.gov/LDlink/. CONTACT: mitchell.machiela@nih.gov.
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| Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations. | Greene CA et al. | β | 2025 | β |
| Muscle AMP deaminase activity was lower in Neandertals than in modern humans. | Macak D et al. | β | 2025 | β |
| Mutations in the bone morphogenetic protein signaling pathway sensitize zebrafish and humans to ethanol-induced jaw malformations. | Klem JR et al. | β | 2025 | β |
| Navigating the blurred boundary: Neuropathologic changes versus clinical symptoms in Alzheimer's disease, and its consequences for research in genetics. | Xavier C et al. | β | 2025 | β |
| Neurobiological correlates of schizophrenia-specific and highly pleiotropic genetic risk scores for neuropsychiatric disorders. | Federmann LM et al. | β | 2025 | β |
| Novel ABCD1 and MTHFSD Variants in Taiwanese Bipolar Disorder: A Genetic Association Study. | Wang YG et al. | β | 2025 | β |
| Novel, complex configurations of the <i>MARCHF6</i> repeat expansion associated with progressive myoclonic epilepsy and familial adult myoclonic epilepsy. | Bennett MF et al. | β | 2025 | β |
| Novel genetic loci and functional properties of immune-related genes for colorectal cancer survival in Korea. | Yun D et al. | β | 2025 | β |
| Novel High-Resolution Lipidomes Could Serve as New Biomarkers for Diabetic Retinopathy: A Bidirectional and Mediated Mendelian Randomization Study. | Sun Y et al. | β | 2025 | β |
| Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study. | Molina-Montes E et al. | β | 2025 | β |
| Physical Activity and Favorable Adiposity Genetic Liability Reduce the Risk of Hypertension Among High Body Mass Individuals. | Hezekiah C et al. | β | 2025 | β |
| PLATELET TRAITS AND SEPSIS RISK AND PROGNOSIS: A BIDIRECTIONAL TWO-SAMPLE MENDELIAN RANDOMIZATION STUDY. | Song Z et al. | β | 2025 | β |
| Post-genome-wide association study dissects genetic vulnerability and risk gene expression of SjΓΆgren's disease for cardiovascular disease. | Yi X et al. | β | 2025 | β |
| Potential Causal Relationship Between Chronic Obstructive Pulmonary Disease and Diabetes: A Bidirectional Two-Sample Mendelian Randomization Study. | Wang X et al. | β | 2025 | β |
| PRED-LD: efficient imputation of GWAS summary statistics. | Manios GA et al. | β | 2025 | β |
| Prioritization of causal genes from genome-wide association studies by Bayesian data integration across loci. | Mousavi Z et al. | β | 2025 | β |
| Regression and machine learning approaches identify potential risk factors for glioblastoma multiforme. | Felici A et al. | β | 2025 | β |
| Regulatory polymorphisms of <i>MSH6</i>, <i>MSH2</i>, <i>FBXO11,</i> and <i>PPP1R21</i> genes affect survival of patients with immunotherapy-treated lung cancer. | Esposito M et al. | β | 2025 | β |
| Risk factors for sacrococcygeal pilonidal sinus: a systematic review and meta-analysis supplemented by genetic causal assessment. | Xu X et al. | β | 2025 | β |
| Role of inflammation in depressive and anxiety disorders, affect, and cognition: genetic and non-genetic findings in the lifelines cohort study. | Mac Giollabhui N et al. | β | 2025 | β |
| Screening of Germline BRCA1 and BRCA2 Variants in Nigerian Breast Cancer Patients. | Onyia AF et al. | β | 2025 | β |
| Sex-stratified association of variants in the serotonin 1A receptor gene with acute crisis pain among African American patients with sickle cell disease. | Sadhu N et al. | β | 2025 | β |
| Shared genetic architecture of type 2 diabetes with muscle mass and function and frailty reveals comorbidity etiology and pleiotropic druggable targets. | Dou C et al. | β | 2025 | β |
| Single nucleotide polymorphisms in the <i>RNASEL</i> gene are associated with acute and late adverse effects of radiotherapy and fatigue in patients with prostate adenocarcinoma. | PetroviΔ N et al. | β | 2025 | β |
| Sleep disorders and aging: Mendelian randomization analysis of epigenetic and frailty markers. | Zhang Z et al. | β | 2025 | β |
| SNP-associated differential methylation in <i>ARHGEF38</i>: insights into genetic-epigenetic interactions. | KovΓ‘cs EHC et al. | β | 2025 | β |
| Starvation activates ECM-remodeling gene transcription and putative enhancers in fibroblasts despite inducing quiescence. | Secchia S et al. | β | 2025 | β |
| Systematic review and independent validation of genetic factors of radiographic outcome in rheumatoid arthritis identifies a genome-wide association with CARD9. | Sharma SD et al. | β | 2025 | β |
| Targeted analysis of dyslexia-associated regions on chromosomes 6, 12 and 15 in large multigenerational cohorts. | Chapman NH et al. | β | 2025 | β |
| The -β216G/T polymorphism in the EGFR gene: A review focusing on Non-Small lung cancer. | Obradovic J et al. | β | 2025 | β |
| The APOL1 p.N264K variant is co-inherited with the G2 kidney disease risk variant through a proximity recombination event. | Simeone CA et al. | β | 2025 | β |
| The association between gut microbiota and accelerated aging and frailty: a Mendelian randomization study. | Yan Z et al. | β | 2025 | β |
| The Beta-Blocker Pharmacogenetic Puzzle: More Pieces of Evidence for Pharmacodynamic Candidate Variants. | Luzum JA et al. | β | 2025 | β |
| The causal relationship between 179 lipid species and urolithiasis: a bidirectional and multivariable Mendelian randomization study combined with meta-analysis. | Wang X et al. | β | 2025 | β |
| The common VTE-protective G haplotype of F5 increases factor V-short, TFPI function, and risk of bleeding. | Sims MC et al. | β | 2025 | β |
| The Effect of Circulating Proteins and Their Role in Mediating Adiposity's Effect on Endometrial Cancer Risk: Mendelian Randomization and Colocalization Analyses. | Wang SE et al. | β | 2025 | β |
| The relationship between smoking and recurrent aphthous stomatitis: A Mendelian randomization study. | Hu Y et al. | β | 2025 | β |
| The role of genetic polymorphisms in pediatric metabolic syndrome: the role of fat mass and obesity-associated (FTO) gene. | Babinski M et al. | β | 2025 | β |
| The Role of Metabolites in CSF on NAFLD Development: A Mendelian Randomisation Analysis. | Liang F et al. | β | 2025 | β |
| The TRIM37 variant rs57141087 contributes to triple-negative breast cancer outcomes in Black women. | Tihagam RD et al. | β | 2025 | β |
| Thrombotic risk determined by <i>ABO</i>, <i>F8</i>, and <i>VWF</i> variants in a population-based cohort study. | Manderstedt E et al. | β | 2025 | β |
| Topological influence of immediate-early genes in brain genetic networks and their link to Alzheimer's disease. | Zachariou M et al. | β | 2025 | β |
| Tracing the evolutionary history of the CCR5delta32 deletion via ancient and modern genomes. | Ravn K et al. | β | 2025 | β |
| Uncovering covariance patterns across energy balance traits enables the discovery of new obesity-related genes. | Gulisija D et al. | β | 2025 | β |
| Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men. | Janivara R et al. | β | 2025 | β |
| Understanding the genetic basis of medication-related osteonecrosis of the jaw: A systematic review. | Radi S et al. | β | 2025 | β |
| Unraveling an enhancer-silencer regulatory element showing epistatic interaction with a variant that escaped genome-wide association studies. | Adjemout M et al. | β | 2025 | β |
| Using blood methylomes to predict response to amisulpride in the first-episode psychosis in the OPTiMiSE cohort. | Lokmer A et al. | β | 2025 | β |
| Using omics data and genome editing methods to decipher GWAS loci associated with coronary artery disease. | Chignon A et al. | β | 2025 | β |
| Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele. | Zhang X et al. | β | 2025 | β |
| Accuracy in drug target Mendelian randomization of maternal and foetal health. | Yang Q et al. | β | 2024 | β |
| A clustering approach to improve our understanding of the genetic and phenotypic complexity of chronic kidney disease. | Eoli A et al. | β | 2024 | β |
| Adaptive and Innate Immunity Are Key Drivers of Age at Onset of Multiple Sclerosis. | Misicka E et al. | β | 2024 | β |
| African ancestry-derived APOL1 risk genotypes show proximal epigenetic associations. | Breeze CE et al. | β | 2024 | β |
| Age at menarche and idiopathic pulmonary fibrosis: a two-sample mendelian randomization study. | Cao J et al. | β | 2024 | β |
| A genetic and proteomic comparison of key AD biomarkers across tissues. | Marsh TW et al. | β | 2024 | β |
| A genome-wide association analysis reveals new pathogenic pathways in gout. | Major TJ et al. | β | 2024 | β |
| A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death. | Minnai F et al. | β | 2024 | β |
| A genome-wide association study identified PTPN2 as a population-specific susceptibility gene locus for primary biliary cholangitis. | Hitomi Y et al. | β | 2024 | β |
| A Genome-wide Association Study of Susceptibility to Upper Urinary Tract Infections. | Flatby HM et al. | β | 2024 | β |
| A genome-wide association study on hematopoietic stem cell transplantation reveals novel genomic loci associated with transplant outcomes. | Rosenberger A et al. | β | 2024 | β |
| A genome-wide meta-analysis of palmoplantar pustulosis implicates T<sub>H</sub>2 responses and cigarette smoking in disease pathogenesis. | Hernandez-Cordero A et al. | β | 2024 | β |
| A Mendelian randomization study: Association of Cathepsin with Osteoarticular Muscle Diseases | Yang W et al. | β | 2024 | β |
| A MR-PheWAS and bidirectional Mendelian randomization study: Exploring for causal relationships of pancreatic cancer. | Guan A et al. | β | 2024 | β |
| A multi-ancestry genome-wide association study in type 1 diabetes. | Michalek DA et al. | β | 2024 | β |
| Analysis of the combined effect of rs699 and rs5051 on angiotensinogen expression and hypertension. | Powell NR et al. | β | 2024 | β |
| Angiotensin receptor blockers modulate the lupus CD4+ T cell epigenome characterized by TNF family-linked signaling. | Hart AP et al. | β | 2024 | β |
| An intronic polymorphism associated with 2,3-bisphosphoglycerate levels in human red cells is linked to expression of RhCE blood groups. | McGowan EC et al. | β | 2024 | β |
| A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children. | de Smith AJ et al. | β | 2024 | β |
| A novel locus in <i>CSMD1</i> gene is associated with increased susceptibility to severe malaria in Malian children. | Damena D et al. | β | 2024 | β |
| A partitioned polygenic risk score reveals distinct contributions to psoriasis clinical phenotypes across a multi-ethnic cohort. | Orcales F et al. | β | 2024 | β |
| Applying a genetic risk score model to enhance prediction of future multiple sclerosis diagnosis at first presentation with optic neuritis. | Loginovic P et al. | β | 2024 | β |
| A regulatory element associated to NAFLD in the promoter of DIO1 controls LDL-C, HDL-C and triglycerides in hepatic cells. | Castillejo-LΓ³pez C et al. | β | 2024 | β |
| Assessing the effects of HMGCR, LPL, and PCSK9 inhibition on sleep apnea: Mendelian randomization analysis of drug targets. | Tan W et al. | β | 2024 | β |
| Assessing the Role of Cortisol in Anxiety, Major Depression, and Neuroticism: A Mendelian Randomization Study Using <i>SERPINA6</i>/<i>SERPINA1</i> Variants. | Chan II et al. | β | 2024 | β |
| Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis. | Yarmolinsky J et al. | β | 2024 | β |
| Association between human blood metabolome and the risk of gastrointestinal tumors. | Lu J et al. | β | 2024 | β |
| Association between inflammatory factors and melanoma: a bidirectional Mendelian randomization study. | Lu J et al. | β | 2024 | β |
| Association between tobacco smoke exposure and depression: the NHANES 2005-2018 and Mendelian randomization study. | Guo Y et al. | β | 2024 | β |
| Association of asthma and bronchiectasis: Mendelian randomization analyses and observational study. | Fan R et al. | β | 2024 | β |
| Association of Body Mass Index and Parkinson Disease: A Bidirectional Mendelian Randomization Study. | Domenighetti C et al. | β | 2024 | β |
| Association of different milk fat content with coronary artery disease and myocardial infarction risk: A Mendelian randomization study. | Wu J et al. | β | 2024 | β |
| Association of Genetic Markers with the Risk of Early-Onset Breast Cancer in Kazakh Women. | Skvortsova L et al. | β | 2024 | β |
| Association of <i>CHD8</i> Gene Polymorphic Variants with the Clinical Phenotype of Autism Spectrum Disorder. | Iwanicki T et al. | β | 2024 | β |
| Association of rs401681 (Cβ>βT) and rs402710 (Cβ>βT) polymorphisms in the CLPTM1L region with risk of lung cancer: a systematic review and meta-analysis. | Wu X et al. | β | 2024 | β |
| Association of specific <i>ACE2</i> and <i>TMPRSS2</i> variants with circulatory cytokines of COVID-19 Emirati patients. | Elemam NM et al. | β | 2024 | β |
| Association of VDR Polymorphisms with Muscle Mass Development in Elite Young Soccer Players: A Pilot Study. | Flore L et al. | β | 2024 | β |
| Associations between antagonistic SNPs for neuropsychiatric disorders and human brain structure. | Federmann LM et al. | β | 2024 | β |
| Associations between diabetes-related genetic risk scores and residual beta cell function in type 1 diabetes: the GUTDM1 study. | Fuhri Snethlage CM et al. | β | 2024 | β |
| Associations between immune cell traits and autoimmune thyroid diseases: a bidirectional two-sample mendelian randomization study. | Cao Z et al. | β | 2024 | β |
| Bivariate genome-wide association study of circulating fibrinogen and C-reactive protein levels. | Hahn J et al. | β | 2024 | β |
| Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry. | Burns K et al. | β | 2024 | β |
| Breakfast skipping and traits of cardiometabolic health: A mendelian randomization study. | Xia M et al. | β | 2024 | β |
| Casual effects of type 1 diabetes mellitus on site-specific digestive cancers: a Mendelian randomisation analysis. | Zhao J et al. | β | 2024 | β |
| Causal association between antidiabetic drugs and erectile dysfunction: evidence from Mendelian randomization. | Feng L et al. | β | 2024 | β |
| Causal association between gastrointestinal diseases and coronary artery disease: a bidirectional Mendelian randomization study. | Wang Z et al. | β | 2024 | β |
| Causal association between metabolites and age-related macular degeneration: a bidirectional two-sample mendelian randomization study. | Liu ZY et al. | β | 2024 | β |
| Causal association of circulating inflammatory proteins on neurodegenerative diseases: Insights from a mendelian randomization study. | Lin W et al. | β | 2024 | β |
| Causal association of epigenetic age acceleration and risk of subacute thyroiditis: a bidirectional Mendelian randomization study. | Shen B et al. | β | 2024 | β |
| Causal associations between gut microbiota, circulating inflammatory proteins, and epilepsy: a multivariable Mendelian randomization study. | Yang H et al. | β | 2024 | β |
| Causal associations between modifiable risk factors and isolated REM sleep behavior disorder: a mendelian randomization study. | Zhang RY et al. | β | 2024 | β |
| Causal associations between psoriasis, eczema, urticaria, and mental illness: A bidirectional Mendelian randomization study of the European population. | Mo N et al. | β | 2024 | β |
| Causal effect of porphyria biomarkers on alcohol-related hepatocellular carcinoma through Mendelian Randomization. | Yang X et al. | β | 2024 | β |
| Causal effects of genetic birth weight and gestational age on adult esophageal diseases: Mendelian randomization study. | Ruan LC et al. | β | 2024 | β |
| Causal relationship between coffee intake and neurological diseases: a Mendelian randomization study. | Zhang J et al. | β | 2024 | β |
| Causal relationship between dyslipidemia and risk of facial aging: Insights from Mendelian randomization in East Asian populations. | Deng Y et al. | β | 2024 | β |
| Causal Relationship Between Ferritin and Neuropsychiatric Disorders: A Two-Sample Mendelian Randomization Study. | Sun W et al. | β | 2024 | β |
| Causal relationship between insomnia and thyroid disease: A bidirectional Mendelian randomization study. | Li Z et al. | β | 2024 | β |
| Causal Relationship between Parkinson's Disease with Heart and Vascular Disease: A Two-Sample Mendelian Randomization Study. | Chen L et al. | β | 2024 | β |
| Causal relationship between sleep characteristics and thyroid function: A bidirectional Mendelian randomization study. | Jia Z et al. | β | 2024 | β |
| Causal relationships between dyslexia and the risk of eight dementias. | Zhu P et al. | β | 2024 | β |
| Causal role of immune cells in uveitis: Mendelian randomization study. | Wu J et al. | β | 2024 | β |
| CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis. | Olivier JF et al. | β | 2024 | β |
| Changes in environmental exposures over decades may influence the genetic architecture of severe spermatogenic failure. | CervΓ‘n-MartΓn M et al. | β | 2024 | β |
| Characteristics associated with response to subcutaneously administered anti-CGRP monoclonal antibody medications in aΒ real-world community cohort of persons living with migraine: AΒ retrospective clinical and genetic study. | Chase BA et al. | β | 2024 | β |
| Cheese consumption on atherosclerosis, atherosclerotic cardiovascular diseases and its complications: A two-sample Mendelian randomization study. | Xie Y et al. | β | 2024 | β |
| Childhood-onset type 1 diabetes and subsequent adult psychiatric disorders: a nationwide cohort and genome-wide Mendelian randomization study. | FormΓ‘nek T et al. | β | 2024 | β |
| ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits. | Singh C et al. | β | 2024 | β |
| Chronic Decrements in Energy in Women with Breast Cancer are Associated with Cytokine Gene Polymorphisms. | Miaskowski C et al. | β | 2024 | β |
| Circulating inflammatory biomarkers and risk of intracranial aneurysm: a Mendelian randomization study. | Fang J et al. | β | 2024 | β |
| Clinical investigation forΒ the mechanisms ofΒ anaphylactic symptoms inΒ osteoarthritis patients after diclofenac etalhyaluronate administration. | Nishida Y et al. | β | 2024 | β |
| Cognitive benefits of folic acid supplementation during pregnancy track with epigenetic changes at an imprint regulator. | Hilman L et al. | β | 2024 | β |
| Colocalised Genetic Associations Reveal Alternative Splicing Variants as Candidate Causal Links for Breast Cancer Risk in 10 Loci. | Besouro-Duarte A et al. | β | 2024 | β |
| Common mental disorders and risk of female infertility: a two-sample Mendelian randomization study. | Mao D et al. | β | 2024 | β |
| Comprehensive Association Analyses of Extraintestinal Manifestations in Inflammatory Bowel Disease. | Khrom M et al. | β | 2024 | β |
| Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank. | Oliveri A et al. | β | 2024 | β |
| Connecting dementia risk loci to the CSF proteome identifies pathophysiological leads for dementia. | Reus LM et al. | β | 2024 | β |
| Contributions of elevated CRP, hyperglycaemia, and type 2 diabetes to cardiovascular risk in the general population: observational and Mendelian randomization studies. | Rolver MG et al. | β | 2024 | β |
| CYP2A6 associates with respiratory disease risk and younger age of diagnosis: a phenome-wide association Mendelian Randomization study. | Giratallah H et al. | β | 2024 | β |
| CYP2C gene polymorphisms in North African populations. | Messaoudi M et al. | β | 2024 | β |
| Deciphering the tissue-specific functional effect of Alzheimer risk SNPs with deep genome annotation. | Pugalenthi PV et al. | β | 2024 | β |
| Deep learning of left atrial structure and function provides link to atrial fibrillation risk. | Pirruccello JP et al. | β | 2024 | β |
| Deep sequencing of candidate genes identified 14 variants associated with smoking abstinence in an ethnically diverse sample. | Cinciripini PM et al. | β | 2024 | β |
| Disparities in ABO blood type determination across diverse ancestries: a systematic review and validation in the All of Us Research Program. | Martinez KL et al. | β | 2024 | β |
| Education and cardiovascular diseases: a Mendelian randomization study. | Liu W et al. | β | 2024 | β |
| Effect modification by sex of genetic associations of vitamin C related metabolites in the Canadian Longitudinal study on aging. | Lelievre R et al. | β | 2024 | β |
| Effect of inflammatory factors on myocardial infarction. | Zeng Q et al. | β | 2024 | β |
| Effect of the Blood Pressure and Antihypertensive Drugs on Cerebral Small Vessel Disease: A Mendelian Randomization Study. | Ma Y et al. | β | 2024 | β |
| Effects of endocrine disrupting chemicals and their interactions with genetic risk scores on cardiometabolic traits. | Lu X et al. | β | 2024 | β |
| Elucidating the causal nexus and immune mediation between frailty and chronic kidney disease: integrative multi-omics analysis. | Zheng G et al. | β | 2024 | β |
| Enhancers regulate genes linked to severe and mild childhood asthma. | Akhter T et al. | β | 2024 | β |
| Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings. | Pauly R et al. | β | 2024 | β |
| Epigenome-wide association study of DNA methylation in maternal blood leukocytes with BMI in pregnancy and gestational weight gain. | Opsahl JO et al. | β | 2024 | β |
| Epilepsy and psychiatric comorbidities: A bidirectional mendelian randomization study. | Chu H et al. | β | 2024 | β |
| Estimation of the Age of the Kashubian-Specific Pathogenic <i>NPHS2</i> Variant Responsible for Hereditary Steroid-Resistant Nephrotic Syndrome Points to Its Recent Local Origin. | Jankowski M et al. | β | 2024 | β |
| Ethnic and region-specific genetic risk variants of stroke and its comorbid conditions can define the variations in the burden of stroke and its phenotypic traits. | Sukumaran R et al. | β | 2024 | β |
| Evaluating the regulatory function of non-coding autism-associated single nucleotide polymorphisms on gene expression in human brain tissue. | Pugsley K et al. | β | 2024 | β |
| Evidence of a Causal Relationship Between Body Mass Index and Immune-Mediated and Inflammatory Skin Diseases and Biomarkers: A Mendelian Randomization Study. | Li Z et al. | β | 2024 | β |
| Exploration of the causal relationship between inflammatory cytokines and prostate carcinoma: a comprehensive Mendelian randomization study. | Cai X et al. | β | 2024 | β |
| Exploring causal correlations between inflammatory cytokines and colorectal cancer: A 2-sample Mendelian randomization study. | Zhou H et al. | β | 2024 | β |
| Exploring causal correlations between inflammatory cytokines and MΓ©niΓ¨re's disease: a Mendelian randomization. | Xie S et al. | β | 2024 | β |
| Exploring Genetic Association of Tea Intake With Allergic Diseases Among European Population: A Bidirectional Mendelian Randomization Study. | Zhang J et al. | β | 2024 | β |
| Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study. | Qiu Y et al. | β | 2024 | β |
| Exploring the causal effect of placental physiology in susceptibility to mental and addictive disorders: a Mendelian randomization study. | JΓ‘come-Ferrer P et al. | β | 2024 | β |
| Expression quantitative trait loci influence DNA damage-induced apoptosis in cancer. | Bigge J et al. | β | 2024 | β |
| Femoral neck width genetic risk score is a novel independent risk factor for hip fractures. | Tobias JH et al. | β | 2024 | β |
| Fibroblast growth factor 23-mediated regulation of osteoporosis: Assessed via Mendelian randomization and inΒ vitro study. | Zhang X et al. | β | 2024 | β |
| FORGEdb: a tool for identifying candidate functional variants and uncovering target genes and mechanisms for complex diseases. | Breeze CE et al. | β | 2024 | β |
| Genetically Determined Circulating Lactase/Phlorizin Hydrolase Concentrations and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study. | Han S et al. | β | 2024 | β |
| Genetically predicted gut bacteria, circulating bacteria-associated metabolites and pancreatic ductal adenocarcinoma: a Mendelian randomisation study. | Daniel N et al. | β | 2024 | β |
| Genetically predicted serum ferritin mediates the association between inflammatory cytokines and non-alcoholic fatty liver disease. | Liu X et al. | β | 2024 | β |
| Genetic analyses of 104 phenotypes in 20,900 Chinese pregnant women reveal pregnancy-specific discoveries. | Xiao H et al. | β | 2024 | β |
| Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology. | Madsen AL et al. | β | 2024 | β |
| Genetic associations between ULK3 and epilepsy: a two-sample Mendelian randomization study. | Liu B et al. | β | 2024 | β |
| Genetic determinants of complement activation in the general population. | Noce D et al. | β | 2024 | β |
| Genetic determinants of IgG antibody response to COVID-19 vaccination. | Bian S et al. | β | 2024 | β |
| Genetic insight into the relationship between inflammatory bowel disease and <i>Clostridioides difficile</i> infection. | Cushing-Damm KC et al. | β | 2024 | β |
| Genetic modifiers of body mass index in individuals with cystic fibrosis. | Ling H et al. | β | 2024 | β |
| Genetic polymorphisms affecting telomere length and their association with cardiovascular disease in the Heinz-Nixdorf-Recall study. | Tannemann N et al. | β | 2024 | β |
| Genetic polymorphisms associated with urinary tract infection in children and adults: aΒ systematic review and meta-analysis. | Yu J et al. | β | 2024 | β |
| Genetic polymorphisms of CYP2C19 in ecuadorian population: An interethnic approach. | Alonso Llorente A et al. | β | 2024 | β |
| Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome. | Drnovsek E et al. | β | 2024 | β |
| Genetic variants associated with response to anti-CGRP monoclonal antibody therapy in a chronic migraine Han Chinese population. | An YC et al. | β | 2024 | β |
| Genetic variation in <i>TAS2R38</i> bitterness receptor is associated with body composition in Korean females. | Jo YS et al. | β | 2024 | β |
| Genome-wide association analysis of treatment resistant schizophrenia for variant discovery and polygenic assessment. | Lenk HΓ et al. | β | 2024 | β |
| Genome-wide association study implicates the role of TBXAS1 in the pathogenesis of depressive symptoms among the Korean population. | Park K et al. | β | 2024 | β |
| Genome-wide association study of early-onset and late-onset postpartum depression: the IGEDEPP prospective study. | Tebeka S et al. | β | 2024 | β |
| Genome-Wide Genetic Analysis of Dropout in a Controlled Exercise Intervention in Sedentary Adults With Overweight or Obesity and Cardiometabolic Disease. | Jiang R et al. | β | 2024 | β |
| Genomic variations associated with risk and protection against vincristine-induced peripheral neuropathy in pediatric cancer patients. | Mufti K et al. | β | 2024 | β |
| Genopyc: a Python library for investigating the functional effects of genomic variants associated to complex diseases. | Gualdi F et al. | β | 2024 | β |
| Germline <i>cis</i> variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (<i>DPYD</i>). | Zhang T et al. | β | 2024 | β |
| Gout-associated SNP at the IL1RN-IL1F10 region is associated with altered cytokine production in PBMCs of patients with gout and controls. | Gaal OI et al. | β | 2024 | β |
| Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa. | Janivara R et al. | β | 2024 | β |
| HLA-DPB1*13:01 associates with enhanced, and KIR2DS4*001 with diminished protection from developing severe COVID-19. | Farias TDJ et al. | β | 2024 | β |
| Host cytokine genetic polymorphisms in a selected population of persons living with hepatitis B virus infection in the central region of Ghana. | Adu F et al. | β | 2024 | β |
| Identification of 27 allele-specific regulatory variants in Parkinson's disease using a massively parallel reporter assay. | Farrow SL et al. | β | 2024 | β |
| Identification Of A Higher Risk Lymphedema Phenotype And Associations With Cytokine Gene Polymorphisms. | Miaskowski C et al. | β | 2024 | β |
| Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates. | Yee SW et al. | β | 2024 | β |
| Impact of CYP2D6*2, CYP2D6*35, rs5758550, and related haplotypes on risperidone clearance in vivo. | StΓΈrset E et al. | β | 2024 | β |
| Impact of insomnia upon inflammatory digestive diseases and biomarkers: a two-sample mendelian randomization research on Europeans. | Dai L et al. | β | 2024 | β |
| Impact of the <i>COL1A1</i> Gene Polymorphisms on Pain Perception in Tennis Elbow Patients: A Two-Year Prospective Cohort Study. | Niemiec P et al. | β | 2024 | β |
| Integrative analysis of noncoding mutations identifies the druggable genome in preterm birth. | Wang C et al. | β | 2024 | β |
| Investigating the Link between <i>STAT4</i> Genetic Variants, STAT4 Protein Concentrations, and Laryngeal Squamous Cell Carcinoma: A Comprehensive Analysis of Clinical Manifestations. | Pileckaite E et al. | β | 2024 | β |
| Investigating the role of iron status in the development of coeliac disease: a Mendelian randomisation study. | Hujoel IA et al. | β | 2024 | β |
| Kidney Function Measures and Mortality: A Mendelian Randomization Study. | Shan Y et al. | β | 2024 | β |
| Landscape of pharmacogenetic variants associated with non-insulin antidiabetic drugs in the Indian population. | Sivadas A et al. | β | 2024 | β |
| Linking Iris Cis-Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics. | Li J et al. | β | 2024 | β |
| Links between melanoma germline risk loci, driver genesΒ and comorbidities: insight from a tissue-specific multi-omic analysis. | Pudjihartono M et al. | β | 2024 | β |
| Lipid Profiles, Telomere Length, and the Risk of Malignant Tumors: A Mendelian Randomization and Mediation Analysis. | Liu S et al. | β | 2024 | β |
| Liver regulatory mechanisms of noncoding variants at lipid and metabolic trait loci. | Pandey GK et al. | β | 2024 | β |
| lncRNA CDKN2B-AS1 regulates collagen expression. | Shi W et al. | β | 2024 | β |
| <i>KLF2</i> enhancer variant rs4808485 increases lupus risk by modulating inflammasome machinery and cellular homoeostasis. | Singh MK et al. | β | 2024 | β |
| Machine learning model identifies genetic predictors of cisplatin-induced ototoxicity in CERS6 and TLR4. | Arab A et al. | β | 2024 | β |
| Mendelian randomization evidence for the causal effect of mental well-being on healthy aging. | Ye CJ et al. | β | 2024 | β |
| Mendelian randomization reveals apolipoprotein B shortens healthspan and possibly increases risk for Alzheimer's disease. | Martin L et al. | β | 2024 | β |
| Mendelian randomization study on the association of circulating ketone bodies with lung cancer and respiratory diseases. | Tang X et al. | β | 2024 | β |
| Metabolic Characteristics of Gut Microbiota and Insomnia: Evidence from a Mendelian Randomization Analysis. | Xie F et al. | β | 2024 | β |
| Methylome-wide and meQTL analysis helps to distinguish treatment response from non-response and pathogenesis markers in schizophrenia. | Polakkattil BK et al. | β | 2024 | β |
| Molecular Mechanisms Linking Genes and Vitamins of the Complex B Related to One-Carbon Metabolism in Breast Cancer: An In Silico Functional Database Study. | GΓ‘lvez-Navas JM et al. | β | 2024 | β |
| Multi-ancestry genome-wide meta-analysis identifies novel basal cell carcinoma loci and shared genetic effects with squamous cell carcinoma. | Choquet H et al. | β | 2024 | β |
| Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk. | Gorman BR et al. | β | 2024 | β |
| NK2R control of energy expenditure and feeding to treat metabolic diseases. | Sass F et al. | β | 2024 | β |
| NK Cytotoxicity Mediated by NK-92 Cell Lines Expressing Combinations of Two Allelic Variants for <i>FCGR3</i>. | Freitas Monteiro M et al. | β | 2024 | β |
| No evidence for a genetic causal effect of breast cancer on venous thromboembolism: a mendelian randomization study. | Qin Q et al. | β | 2024 | β |
| No Genetic Causality between Tobacco Smoking and Venous Thromboembolism: A Two-Sample Mendelian Randomization Study. | Du HC et al. | β | 2024 | β |
| Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia. | Ochs-Balcom HM et al. | β | 2024 | β |
| Novel genetic association of the Furin gene polymorphism rs1981458 with COVID-19 severity among Indian populations. | Pandey RK et al. | β | 2024 | β |
| Novel genetic insight for psoriasis: integrative genome-wide analyses in 863Β 080 individuals and proteome-wide Mendelian randomization. | Liu S et al. | β | 2024 | β |
| Obesity, Glycemic Traits, Lifestyle Factors, and Risk of Facial Aging: A Mendelian Randomization Study in 423,999 Participants. | Liu XJ et al. | β | 2024 | β |
| Obesity-Related Traits Mediate the Effects of Educational Attainment on the Risk of Varicose Veins, Venous Thromboembolism, and Phlebitis. | Du HC et al. | β | 2024 | β |
| OVCH1 Antisense RNA 1 is differentially expressed between non-frail and frail old adults. | Abugessaisa I et al. | β | 2024 | β |
| Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease. | Jamialahmadi O et al. | β | 2024 | β |
| Percentage of fat in milk consumption and risk of six cancers: a Mendelian randomization study. | Bai T et al. | β | 2024 | β |
| Peripheral immune cell abundance differences link blood mitochondrial DNA copy number and Parkinson's disease. | Wang L et al. | β | 2024 | β |
| Pharmacokinetics and pharmacogenomics of ribociclib in black patients with metastatic breast cancer the LEANORA study. | Schlam I et al. | β | 2024 | β |
| Phenome-Wide Association Study of Latent Autoimmune Diabetes from a Southern Mexican Population Implicates rs7305229 with Plasmatic Anti-Glutamic Acid Decarboxylase Autoantibody (GADA) Levels. | Nolasco-Rosales GA et al. | β | 2024 | β |
| Physical Activity, Sedentary Behavior, and Pancreatic Cancer Risk: A Mendelian Randomization Study. | Gentiluomo M et al. | β | 2024 | β |
| Placental efflux transporters and antiseizure or antidepressant medication use impact birth weight in MoBa cohort. | Hernandez MH et al. | β | 2024 | β |
| Plasma adiponectin levels and risk of heart failure, atrial fibrillation, aortic valve stenosis, and myocardial infarction: large-scale observational and Mendelian randomization evidence. | Nielsen MB et al. | β | 2024 | β |
| Pleiotropic Associations with Alzheimer's Disease and Physical Activity: Sex Differences and the Effects of Environment. | Loika Y et al. | β | 2024 | β |
| Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian case-control cohort. | Boumtje V et al. | β | 2024 | β |
| Polygenic profiles define aspects of clinical heterogeneity in attention deficit hyperactivity disorder. | LaBianca S et al. | β | 2024 | β |
| [Polymorphic variants in the cluster of genes encoding trace amine receptors and cognitive functioning in patients with schizophrenia spectrum disorders and healthy controls]. | Alfimova MV et al. | β | 2024 | β |
| Predicting functional UTR variants by integrating region-specific features. | Li G et al. | β | 2024 | β |
| Protein-truncating variant in APOL3 increases chronic kidney disease risk in epistasis with APOL1 risk alleles. | Zhang DY et al. | β | 2024 | β |
| Risk of anthracycline-induced cardiac dysfunction in adolescent and young adult (AYA) cancer survivors: role of genetic susceptibility loci. | Stafford LK et al. | β | 2024 | β |
| Role of interleukin-18 in mediating the impacts of celiac disease on osteoporosis: a Mendelian randomization study. | Xiang J et al. | β | 2024 | β |
| rs10924104 in the expression enhancer motif of CD58 confers susceptibility to human autoimmune diseases. | Hitomi Y et al. | β | 2024 | β |
| Serum vitamin D concentrations and sleep disorders: insights from NHANES 2011-2016 and Mendelian Randomization analysis. | Jiang J et al. | β | 2024 | β |
| Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis. | Pott J et al. | β | 2024 | β |
| Sex-specific genetic architecture of blood pressure. | Yang ML et al. | β | 2024 | β |
| Single-Cell Transcriptomic and Targeted Genomic Profiling Adjusted for Inflammation and Therapy Bias Reveal <i>CRTAM</i> and <i>PLCB1</i> as Novel Hub Genes for Anti-Tumor Necrosis Factor Alpha Therapy Response in Crohn's Disease. | Gorenjak M et al. | β | 2024 | β |
| Single nucleotide polymorphisms in the cannabinoid CB<sub>2</sub> receptor: Molecular pharmacology and disease associations. | Foyzun T et al. | β | 2024 | β |
| Single-nucleus multi-omics of Parkinson's disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networks. | Shwab EK et al. | β | 2024 | β |
| SPATS2L is a positive feedback regulator of the type I interferon signaling pathway and plays a vital role in lupus. | Chen M et al. | β | 2024 | β |
| Syndrome-informed phenotyping identifies a polygenic background for achondroplasia-like facial variation in the general population. | Vanneste M et al. | β | 2024 | β |
| Tea intake and lung diseases: a Mendelian randomization study. | Wu Z et al. | β | 2024 | β |
| The 330 risk loci known for systemic lupus erythematosus (SLE): a review. | Laurynenka V et al. | β | 2024 | β |
| The ABC's of Alzheimer risk gene ABCA7. | Duchateau L et al. | β | 2024 | β |
| The bidirectional associations between sarcopenia-related traits and cognitive performance. | Lu CF et al. | β | 2024 | β |
| The causal association between body fat distribution and risk of abdominal wall hernia: a two-sample Mendelian randomization study. | Xv Y et al. | β | 2024 | β |
| The causality between systemic inflammatory regulators and chronic respiratory diseases: A bidirectional Mendelian-randomization study. | Jiang G et al. | β | 2024 | β |
| The causal relationship between trace element status and upper gastrointestinal ulcers: a Mendelian randomization study. | Liu J et al. | β | 2024 | β |
| The causal relationship of DTI phenotypes and epilepsy: A two sample mendelian randomization study. | Feng S et al. | β | 2024 | β |
| The Clinical Significance of <i>CRNDE</i> Gene Methylation, Polymorphisms, and CRNDEP Micropeptide Expression in Ovarian Tumors. | Szafron LA et al. | β | 2024 | β |
| The COL5A1 Gene Allelic Combination and ACL Injury Risk in Team Sport: A Preliminary Report. | CalΓ² CM et al. | β | 2024 | β |
| The DLEU2-miR-15a-16-1 Cluster Is a Determinant of Bone Microarchitecture and Strength in Postmenopausal Women and Mice. | Reppe S et al. | β | 2024 | β |
| The effect of androgens on the risk of endometriosis sub-phenotypes and ovarian neoplasms: A Mendelian randomization study. | Gjorgoska M et al. | β | 2024 | β |
| The effect of histo-blood group ABO system transferase (BGAT) on pregnancy related outcomesοΌA Mendelian randomization study. | Sun Y et al. | β | 2024 | β |
| The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response. | SΓ¦terstad S et al. | β | 2024 | β |
| The genetic dissection of fetal haemoglobin persistence in sickle cell disease in Nigeria. | Ojewunmi OO et al. | β | 2024 | β |
| The genetics and epidemiology of N- and O-immunoglobulin A glycomics. | Visconti A et al. | β | 2024 | β |
| The GWAS SNP rs80207740 modulates erythrocyte traits via allele-specific binding of IKZF1 and targeting XPO7 gene. | Hu X et al. | β | 2024 | β |
| The HLA region in ANCA-associated vasculitis: characterisation of genetic associations in a Scandinavian patient population. | Lundtoft C et al. | β | 2024 | β |
| The impact of coffee consumption on osteoarthritis: insights from NHANES and Mendelian randomization analysis. | Feng K et al. | β | 2024 | β |
| The local environment and germline genetic variation predict cancer risk in the UK Biobank prospective cohort. | Felici A et al. | β | 2024 | β |
| Therapeutic efficacy of generic artemether-lumefantrine in the treatment of uncomplicated malaria in Ghana: assessing anti-malarial efficacy amidst pharmacogenetic variations. | Thomford NE et al. | β | 2024 | β |
| The SNP rs460089 in the gene promoter of the drug transporter OCTN1 has prognostic value for treatment-free remission in chronic myeloid leukemia patients treated with imatinib. | Machova Polakova K et al. | β | 2024 | β |
| TransferGWAS of T1-weighted brain MRI data from UK Biobank. | Rakowski A et al. | β | 2024 | β |
| Unraveling the genetic basis of the causal association between inflammatory cytokines and osteonecrosis. | Lu Y et al. | β | 2024 | β |
| Unveiling the causal link between metabolic factors and ovarian cancer risk using Mendelian randomization analysis. | Han L et al. | β | 2024 | β |
| Updated DPYD HapB3 haplotype structure and implications for pharmacogenomic testing. | Turner AJ et al. | β | 2024 | β |
| Using genetics to investigate the association between lanosterol and cataract. | Hashimi M et al. | β | 2024 | β |
| Variant to gene mapping for carpal tunnel syndrome risk loci implicates skeletal muscle regulatory elements. | Pahl MC et al. | β | 2024 | β |
| Walking pace is a protective factor for rheumatoid arthritis: a mendelian randomization study. | Zhang Q et al. | β | 2024 | β |
| Whole Genome Linkage and Association Analyses Identify DLG Associated Protein-1 as a Novel Positional and Biological Candidate Gene for Muscle Strength: The Long Life Family Study. | Santanasto AJ et al. | β | 2024 | β |
| ABCA7-Associated Clinical Features and Molecular Mechanisms in Alzheimer's Disease. | Qian XH et al. | β | 2023 | β |
| A common genetic variation in <i>GZMB</i> may associate with cancer risk in patients with Lynch syndrome. | Grolmusz VK et al. | β | 2023 | β |
| A frequent CYP2D6 variant promotes skipping of exon 3 and reduces CYP2D6 protein expression in human liver samples. | Collins JM et al. | β | 2023 | β |
| A genome-wide association scan reveals novel loci for facial traits of Koreans. | Cho HW et al. | β | 2023 | β |
| Alzheimer Disease and Epilepsy: A Mendelian Randomization Study. | Fang Y et al. | β | 2023 | β |
| Analysis of genetically determined gene expression suggests role of inflammatory processes in exfoliation syndrome. | Hirbo JB et al. | β | 2023 | β |
| An atlas of genetic determinants of forearm fracture. | Nethander M et al. | β | 2023 | β |
| An atrial fibrillation-associated regulatory region modulates cardiac <i>Tbx5</i> levels and arrhythmia susceptibility. | Bosada FM et al. | β | 2023 | β |
| An immunogenetic investigation of 30 autoimmune and autoinflammatory diseases and their links to psychiatric disorders in a nationwide sample. | Nudel R et al. | β | 2023 | β |
| A Non-Coding Fc Gamma Receptor Cis-Regulatory Variant within the 1q23 Gene Cluster Is Associated with <i>Plasmodium falciparum</i> Infection in Children Residing in Burkina Faso. | Cretin J et al. | β | 2023 | β |
| A Non-Coding Variant in <i>SLC15A4</i> Modulates Enhancer Activity and Lysosomal Deacidification Linked to Lupus Susceptibility. | Singh MK et al. | β | 2023 | β |
| Antioxidants, minerals and vitamins in relation to Crohn's disease and ulcerative colitis: A Mendelian randomization study. | Chen J et al. | β | 2023 | β |
| A partitioned 88-loci psoriasis genetic risk score reveals HLA and non-HLA contributions to clinical phenotypes in a Newfoundland psoriasis cohort. | Bui A et al. | β | 2023 | β |
| APOE-Ξ΅4 and BIN1 increase risk of Alzheimer's disease pathology but not specifically of Lewy body pathology. | Talyansky S et al. | β | 2023 | β |
| Archaic Introgression Shaped Human Circadian Traits. | Velazquez-Arcelay K et al. | β | 2023 | β |
| A signature of platelet reactivity in CBC scattergrams reveals genetic predictors of thrombotic disease risk. | Verdier H et al. | β | 2023 | β |
| Assessing the Evidence for Causal Associations Between Body Mass Index, C-Reactive Protein, Depression, and Reported Trauma Using Mendelian Randomization. | Palmos AB et al. | β | 2023 | β |
| Assessments of dietary intake and polygenic risk score in associations with colorectal cancer risk: evidence from the UK Biobank. | Hoang T et al. | β | 2023 | β |
| Association between Arachidonic Acid and the Risk of Schizophrenia: A Cross-National Study and Mendelian Randomization Analysis. | Gao Y et al. | β | 2023 | β |
| Association between genetically proxied PCSK9 inhibition and prostate cancer risk: A Mendelian randomisation study. | Fang S et al. | β | 2023 | β |
| Association between the LRP1B and APOE loci and the development of Parkinson's disease dementia. | Real R et al. | β | 2023 | β |
| Association of educational attainment with esophageal cancer, Barrett's esophagus, and gastroesophageal reflux disease, and the mediating role of modifiable risk factors: A Mendelian randomization study. | Zhang X et al. | β | 2023 | β |
| Association of functional, inherited vitamin D-binding protein variants with melanoma-specific death. | Gibbs DC et al. | β | 2023 | β |
| Association of <i>CETP</i> Gene Polymorphisms and Haplotypes with Cardiovascular Risk. | Piko P et al. | β | 2023 | β |
| Association of <i>OPRM1</i>, <i>MIR23B</i>, and <i>MIR107</i> genetic variability with acute pain, chronic pain and adverse effects after postoperative tramadol and paracetamol treatment in breast cancer. | Vidic Z et al. | β | 2023 | β |
| Association of PDGFRA polymorphisms with the risk of corneal astigmatism in a Japanese population. | Fukasaku H et al. | β | 2023 | β |
| Associations of common genetic risk variants of the muscarinic acetylcholine receptor M2 with cardiac autonomic dysfunction in patients with schizophrenia. | Refisch A et al. | β | 2023 | β |
| A systematic review of genome-wide association studies for pain, nociception, neuropathy, and pain treatment responses. | Li S et al. | β | 2023 | β |
| Atopic Polygenic Risk Score Is Associated with Paradoxical Eczema Developing in Patients with Psoriasis Treated with Biologics. | Al-Janabi A et al. | β | 2023 | β |
| Australian genome-wide association study confirms higher female risk for adult glioma associated with variants in the region of CCDC26. | Alpen K et al. | β | 2023 | β |
| B4GALNT3 regulates glycosylation of sclerostin and bone mass. | MovΓ©rare-Skrtic S et al. | β | 2023 | β |
| Birth Weight, Cardiometabolic Factors, and Coronary Heart Disease: A Mendelian Randomization Study. | Su S et al. | β | 2023 | β |
| Borderline personality disorder and thyroid diseases: a Mendelian randomization study. | Wang Q et al. | β | 2023 | β |
| Bounding the average causal effect in Mendelian randomisation studies with multiple proposed instruments: An application to prenatal alcohol exposure and attention deficit hyperactivity disorder. | Diemer EW et al. | β | 2023 | β |
| Candidate biomarkers from the integration of methylation and gene expression in discordant autistic sibling pairs. | Perini S et al. | β | 2023 | β |
| Candidate Genes for IgA Nephropathy in Pediatric Patients: Exome-Wide Association Study. | Buianova AA et al. | β | 2023 | β |
| Causal associations between circulation Ξ²-carotene and cardiovascular disease: A Mendelian randomization study. | Liu S et al. | β | 2023 | β |
| Causal associations between prodromal infection and neuromyelitis optica spectrum disorder: A Mendelian randomization study. | Wang L et al. | β | 2023 | β |
| Causal associations between serum amino acid levels and osteoarthritis: a Mendelian randomization study. | Cui ZY et al. | β | 2023 | β |
| Causal effect of gut-microbiota-derived metabolite trimethylamine N-oxide on Parkinson's disease: A Mendelian randomization study. | Zhou H et al. | β | 2023 | β |
| Causal Effect of Relative Carbohydrate Intake on Hypertension through Psychological Well-Being and Adiposity: A Mendelian Randomization Study. | Ye C et al. | β | 2023 | β |
| Causal effects of specific gut microbiota on bone mineral density: a two-sample Mendelian randomization study. | Chen S et al. | β | 2023 | β |
| Causal relationship between lung diseases and risk of esophageal cancer: insights from Mendelian randomization. | Zhou J et al. | β | 2023 | β |
| Causal relationships between circulating inflammatory factors and IgA vasculitis: a bidirectional Mendelian randomization study. | Qin J et al. | β | 2023 | β |
| Chickenpox and multiple sclerosis: A Mendelian randomization study. | Zhu G et al. | β | 2023 | β |
| Circulating levels of micronutrients and risk of infections: a Mendelian randomization study. | Flatby HM et al. | β | 2023 | β |
| Circulating macrophage colony-stimulating factor levels and stroke: A Mendelian randomization study. | Cao L et al. | β | 2023 | β |
| Circulating Proteins Influencing Psychiatric Disease: A Mendelian Randomization Study. | Lu T et al. | β | 2023 | β |
| Cold-induced vasodilation response in a Japanese cohort: insights from cold-water immersion and genome-wide association studies. | Yasukochi Y et al. | β | 2023 | β |
| Constructing a polygenic risk score for childhood obesity using functional data analysis. | Craig SJC et al. | β | 2023 | β |
| Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study. | Rodriguez-Martin I et al. | β | 2023 | β |
| Cross-phenotype association analysis of gastric cancer: in-silico functional annotation based on the disease-gene network. | Lee S et al. | β | 2023 | β |
| CVD-associated SNPs with regulatory potential reveal novel non-coding disease genes. | Zhu C et al. | β | 2023 | β |
| CXADR polymorphism rs6517774 modifies islet autoimmunity characteristics and exhibits sex disparity. | NygΓ₯rd L et al. | β | 2023 | β |
| Development and testing of a polygenic risk score for breast cancer aggressiveness. | Shieh Y et al. | β | 2023 | β |
| Dissecting Causal Associations of Diet-Derived Circulating Antioxidants with Six Major Mental Disorders: A Mendelian Randomization Study. | Zhao H et al. | β | 2023 | β |
| Dissecting the cross-trait effects of the FOXP2 GWAS hit on clinical and brain phenotypes in adults with ADHD. | Meyer GP et al. | β | 2023 | β |
| DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood. | Issarapu P et al. | β | 2023 | β |
| Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study. | Yu Chen H et al. | β | 2023 | β |
| Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism. | Iglesias MJ et al. | β | 2023 | β |
| Elucidation of the low-expressing erythroid CR1 phenotype by bioinformatic mining of the GATA1-driven blood-group regulome. | Wu PC et al. | β | 2023 | β |
| ensemblQueryR: fast, flexible and high-throughput querying of Ensembl LD API endpoints in R. | Fairbrother-Browne A et al. | β | 2023 | β |
| Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes. | Fragoso-Bargas N et al. | β | 2023 | β |
| Evaluation of SNPs associated with mammographic density in European women with mammographic density in Asian women from South-East Asia. | Mariapun S et al. | β | 2023 | β |
| Exome-wide analysis reveals role of <i>LRP1</i> and additional novel loci in cognition. | Chakraborty S et al. | β | 2023 | β |
| Exploring genetic influences on adverse outcome pathways using heuristic simulation and graph data science. | Romano JD et al. | β | 2023 | β |
| Expression of <i>INPP5D</i> Isoforms in Human Brain: Impact of Alzheimer's Disease Neuropathology and Genetics. | Zajac DJ et al. | β | 2023 | β |
| Four missense genetic variants in <i>CUBN</i> are associated with higher levels of eGFR in non-diabetes but not in diabetes mellitus or its subtypes: A genetic association study in Europeans. | Uglebjerg N et al. | β | 2023 | β |
| Gene-Environment Analyses Reveal Novel Genetic Candidates with Prenatal Tobacco Exposure in Relation to Risk for Childhood Acute Lymphoblastic Leukemia. | Zhong C et al. | β | 2023 | β |
| Genetically predicted circulating levels of cytokines and the risk of oral cavity and pharyngeal cancer: a bidirectional mendelian-randomization study. | Wu K et al. | β | 2023 | β |
| Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder. | Siecinski SK et al. | β | 2023 | β |
| Genetic Architecture of Ischaemic Strokes after COVID-19 Shows Similarities with Large Vessel Strokes. | LluciΓ -Carol L et al. | β | 2023 | β |
| Genetic Evidence for Causal Effects of Socioeconomic, Lifestyle, and Cardiometabolic Factors on Epigenetic-Age Acceleration. | Kong L et al. | β | 2023 | β |
| Genetic factors, adherence to healthy lifestyle behaviors, and risk of bladder cancer. | He Q et al. | β | 2023 | β |
| Genetic Factors Contribute to the Phenotypic Variability in GJB2-Related Hearing Impairment. | Chiang YT et al. | β | 2023 | β |
| Genetic liability to migraine and functional outcome after ischemic stroke. | Wang M et al. | β | 2023 | β |
| Genetic Mimicry Analysis Reveals the Specific Lipases Targeted by the ANGPTL3-ANGPTL8 Complex and ANGPTL4. | Landfors F et al. | β | 2023 | β |
| Genetic perspectives on the influence of circulating cytokines on acne: A Mendelian randomization study. | Li J et al. | β | 2023 | β |
| Genetics and epigenetics of primary SjΓΆgren syndrome: implications for future therapies. | Thorlacius GE et al. | β | 2023 | β |
| GeneticsMakie.jl: a versatile and scalable toolkit for visualizing locus-level genetic and genomic data. | Kim M et al. | β | 2023 | β |
| Genetics of Neurogenic Orthostatic Hypotension in Parkinson's Disease, Results from a Cross-Sectional In Silico Study. | Chevalier G et al. | β | 2023 | β |
| Genetics of osteonecrosis in children and adults with systemic lupus erythematosus. | Webber D et al. | β | 2023 | β |
| Genetic susceptibility to cognitive decline following craniospinal irradiation for pediatric central nervous system tumors. | Brown AL et al. | β | 2023 | β |
| Genetic Validation of Psoriasis Phenotyping in UK Biobank Supports the Utility of Self-Reported Data and Composite Definitions for Large Genetic and Epidemiological Studies. | Saklatvala JR et al. | β | 2023 | β |
| Genetic Variability in <i>VEGFA</i> Gene Influences the Effectiveness of Tennis Elbow Therapy with PRP: A Two-Year Prospective Cohort Study. | Niemiec P et al. | β | 2023 | β |
| Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection. | Ferar K et al. | β | 2023 | β |
| Genetic variations in human ATP2B4 gene alter Plasmodium falciparum in vitro growth in RBCs from Gambian adults. | Joof F et al. | β | 2023 | β |
| Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH. | Li JH et al. | β | 2023 | β |
| Genome-wide association analysis of plasma lipidome identifies 495 genetic associations. | Ottensmann L et al. | β | 2023 | β |
| Genome-Wide Association and Inheritance-Based Analyses Implicate Unconventional Myosin Genes in Hypoplastic Left Heart Syndrome. | Theis JL et al. | β | 2023 | β |
| Genome-wide association studies reveal shared genetic haplotypes of autoimmune rheumatic and endocrine diseases with psychiatric disorders. | Voskarides K et al. | β | 2023 | β |
| Genome-wide association study identifies four pan-ancestry loci for suicidal ideation in the Million Veteran Program. | Ashley-Koch AE et al. | β | 2023 | β |
| Genome-wide association study identifies novel susceptibilities to adult moyamoya disease. | Jeon JP et al. | β | 2023 | β |
| Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer's disease related proteins. | Oatman SR et al. | β | 2023 | β |
| Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response. | Pagadala M et al. | β | 2023 | β |
| Glucocorticoid Receptor Gene (<i>NR3C1</i>) Polymorphisms and Metabolic Syndrome: Insights from the Mennonite Population. | Kolb KL et al. | β | 2023 | β |
| Haplotype-based analysis resolves missing heritability in oculocutaneous albinism type 1B. | Loftus SK et al. | β | 2023 | β |
| High-throughput PRIME-editing screens identify functional DNA variants in the human genome. | Ren X et al. | β | 2023 | β |
| Host genetic determinants of COVID-19 susceptibility and severity: A systematic review and meta-analysis. | Eshetie S et al. | β | 2023 | β |
| Human and pathogen genotype-by-genotype interactions in the light of coevolution theory. | RΓ₯berg L | β | 2023 | β |
| Identification of Novel Intronic SNPs in Transporter Genes Associated with Metformin Side Effects. | Schweighofer N et al. | β | 2023 | β |
| Identification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans. | Kimbrel NA et al. | β | 2023 | β |
| Identifying the mediating role of socioeconomic status on the relationship between schizophrenia and major depressive disorder: a Mendelian randomisation analysis. | Xu Q et al. | β | 2023 | β |
| IGF1 and Insulin Receptor Single Nucleotide Variants Associated with Response in HER2-Negative Breast Cancer Patients Treated with Neoadjuvant Chemotherapy with or without a Fasting Mimicking Diet (BOOG 2013-04 DIRECT Trial). | de Gruil N et al. | β | 2023 | β |
| Impact of NFIB and CYP1A variants on clozapine serum concentration-A retrospective naturalistic cohort study on 526 patients with known smoking habits. | Lenk HΓ et al. | β | 2023 | β |
| Increasing serum iron levels and their role in the risk of infectious diseases: a Mendelian randomization approach. | Butler-Laporte G et al. | β | 2023 | β |
| Independent Associated SNPs at SORCS3 and Its Protein Interactors for Multiple Brain-Related Disorders and Traits. | Kamran M et al. | β | 2023 | β |
| Individual or familial diabetes in relation to eight cardiovascular diseases: A two-sample Mendelian randomization study. | Hu MJ et al. | β | 2023 | β |
| Inflammatory cytokines and two subtypes of breast cancer: A two-sample mendelian randomization study. | Zhou H et al. | β | 2023 | β |
| Influence of alcohol consumption and alcohol metabolism variants on breast cancer risk among Black women: results from the AMBER consortium. | Young KL et al. | β | 2023 | β |
| Integrating plasma proteomes with genome-wide association data for causal protein identification in multiple myeloma. | Wang Q et al. | β | 2023 | β |
| Integrative Mendelian randomization reveals the soluble receptor for advanced glycation end products as protective in relation to rheumatoid arthritis. | Lee GY et al. | β | 2023 | β |
| Inter- and intra-chromosomal modulators of the APOE Ι2 and Ι4 effects on the Alzheimer's disease risk. | Nazarian A et al. | β | 2023 | β |
| Investigating a possible causal relationship between maternal serum urate concentrations and offspring birthweight: a Mendelian randomization study. | Decina CS et al. | β | 2023 | β |
| Investigating causality in the association between DNA methylation and type 2 diabetes using bidirectional two-sample Mendelian randomisation. | Juvinao-Quintero DL et al. | β | 2023 | β |
| Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach. | Wong WLE et al. | β | 2023 | β |
| KLKB1 and CLSTN2 are associated with HDL-mediated cholesterol efflux capacity in a genome-wide association study. | Schachtl-Riess JF et al. | β | 2023 | β |
| Large registry-based analysis of genetic predisposition to tuberculosis identifies genetic risk factors at HLA. | Tervi A et al. | β | 2023 | β |
| Large-scale functional screen identifies genetic variants with splicing effects in modern and archaic humans. | Rong S et al. | β | 2023 | β |
| LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry. | Katsumata Y et al. | β | 2023 | β |
| Leptin and IGF-1 in Infancy Are Associated With Variants in DHCR7 and CYP2R1 That Relate With Type 1 Diabetes and 25OHD. | Eleftheriou A et al. | β | 2023 | β |
| Leveraging epigenomes and three-dimensional genome organization for interpreting regulatory variation. | Baur B et al. | β | 2023 | β |
| Leveraging osteoclast genetic regulatory data to identify genes with a role in osteoarthritis. | Mullin BH et al. | β | 2023 | β |
| Lipocalin 2 - mutation screen and serum levels in patients with anorexia nervosa or obesity and in lean individuals. | Zheng Y et al. | β | 2023 | β |
| <i>InΒ vivo</i> interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution. | Fischer A et al. | β | 2023 | β |
| Machine Learning Application Identifies Germline Markers of Hypertension in Patients With Ovarian Cancer Treated With Carboplatin, Taxane, and Bevacizumab. | Polano M et al. | β | 2023 | β |
| Mendelian randomization evidence for the causal effects of socio-economic inequality on human longevity among Europeans. | Ye CJ et al. | β | 2023 | β |
| Mendelian Randomization Study Does Not Support a Bidirectional Link between Atherosclerosis and Venous Thromboembolism. | Hu M et al. | β | 2023 | β |
| Metabolic drivers of dysglycemia in pregnancy: ethnic-specific GWAS of 146 metabolites and 1-sample Mendelian randomization analyses in a UK multi-ethnic birth cohort. | Fuller H et al. | β | 2023 | β |
| Multi-ancestry genome-wide analysis identifies shared genetic effects and common genetic variants for self-reported sleep duration. | Scammell BH et al. | β | 2023 | β |
| Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification. | Kavousi M et al. | β | 2023 | β |
| Multiancestry sex-stratified genomic associations with HIV viral load and controller status from the ICGH. | Vergara C et al. | β | 2023 | β |
| Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival. | Sun Z et al. | β | 2023 | β |
| Neither Gastric Bypass Surgery Nor Diet-Induced Weight-Loss Affect OATP1B1 Activity as Measured by Rosuvastatin Oral Clearance. | Hovd M et al. | β | 2023 | β |
| No evidence of genetic causality between diabetes and osteonecrosis: a bidirectional two-sample Mendelian randomization analysis. | Li W et al. | β | 2023 | β |
| Novel Association of the NOTCH Pathway Regulator MIB1 Gene With the Development of Bicuspid Aortic Valve. | Tessler I et al. | β | 2023 | β |
| Omega-3 Fatty Acids Interact with <i>DPP10</i> Region Genotype in Association with Childhood Atopy. | Lee-Sarwar KA et al. | β | 2023 | β |
| Omics-driven investigation of the biology underlying intrinsic submaximal working capacity and its trainability. | Hota M et al. | β | 2023 | β |
| Opposing effects of genetic variation in MTCH2 for obesity versus heart failure. | Fischer JA et al. | β | 2023 | β |
| Outlining cardiac ion channel protein interactors and their signature in the human electrocardiogram. | Maurya S et al. | β | 2023 | β |
| Pervasive Sharing of Causal Genetic Risk Factors Contributes to Clinical and Molecular Overlap between SjΓΆgren's Disease and Systemic Lupus Erythematosus. | Chau K et al. | β | 2023 | β |
| Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire. | Andreu-SΓ‘nchez S et al. | β | 2023 | β |
| Polygenic prediction of preeclampsia and gestational hypertension. | Honigberg MC et al. | β | 2023 | β |
| Predicting brain-regional gene regulatory networks from multi-omics for Alzheimer's disease phenotypes and Covid-19 severity. | Khullar S et al. | β | 2023 | β |
| Prospective Blood Transcriptomics Study in a Motor Vehicle Collision Cohort Identified a Protective Function of the SAMD15 Gene Against Chronic Pain. | Parisien M et al. | β | 2023 | β |
| Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life. | Walker KA et al. | β | 2023 | β |
| Rare variant analyses in large-scale cohorts identified SLC13A1 associated with chronic pain. | Ao X et al. | β | 2023 | β |
| Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study. | Qin C et al. | β | 2023 | β |
| Role of 19 SNPs in 10 genes with type 2 diabetes in the Pakistani population. | Khan N et al. | β | 2023 | β |
| Role of the redox state of the Pirin-bound cofactor on interaction with the master regulators of inflammation and other pathways. | Ahsan T et al. | β | 2023 | β |
| RSPO4 is a potential risk gene of stages III-IV, grade C periodontitis through effects on innate immune response and oral barrier integrity. | Chopra A et al. | β | 2023 | β |
| RTEL1 gene polymorphisms and neuroblastoma risk in Chinese children. | Zhang T et al. | β | 2023 | β |
| SDC4-rs1981429 and ATM-rs228590 may provide early biomarkers of breast cancer risk. | Vuorinen SI et al. | β | 2023 | β |
| Sequencing-based fine-mapping and in silico functional characterization of the 10q24.32 arsenic metabolism efficiency locus across multiple arsenic-exposed populations. | Chernoff MB et al. | β | 2023 | β |
| Sex- and APOE-specific genetic risk factors for late-onset Alzheimer's disease: Evidence from gene-gene interaction of longevity-related loci. | Dato S et al. | β | 2023 | β |
| Sex and Race Differences in Obesity-Related Genetic Susceptibility and Risk of Cardiometabolic Disease in Older US Adults. | Yu H et al. | β | 2023 | β |
| Sex-Dimorphic Analyses Identify Novel and Sex-Specific Genetic Associations in Inflammatory Bowel Disease. | Khrom M et al. | β | 2023 | β |
| Sex-Specific Associations of <i>MDM2</i> and <i>MDM4</i> Variants with Risk of Multiple Primary Melanomas and Melanoma Survival in Non-Hispanic Whites. | Ward SV et al. | β | 2023 | β |
| Shared genetic architecture of COVID-19 and Alzheimer's disease. | Matveeva N et al. | β | 2023 | β |
| SNP of Aromatase Predict Long-term Survival and Aromatase Inhibitor Toxicity in Patients with Early Breast Cancer: A Biomarker Analysis of the GIM4 and GIM5 Trials. | Conte B et al. | β | 2023 | β |
| Socioeconomic status may affect association of vegetable intake with risk of ischemic cardio-cerebral vascular disease: a Mendelian randomization study. | Huang J et al. | β | 2023 | β |
| Soluble adhesion molecules and functional outcome after ischemic stroke: A Mendelian randomization study. | Wang M et al. | β | 2023 | β |
| Stratified genome-wide association analysis of type 2 diabetes reveals subgroups with genetic and environmental heterogeneity. | Christiansen CE et al. | β | 2023 | β |
| Syndecan-4 as a genetic determinant of the metabolic syndrome. | Crocco P et al. | β | 2023 | β |
| Systemic inflammatory regulators and proliferative diabetic retinopathy: A bidirectional Mendelian randomization study. | Shi Q et al. | β | 2023 | β |
| Targeted long-read sequencing of the Ewing sarcoma 6p25.1 susceptibility locus identifies germline-somatic interactions with EWSR1-FLI1 binding. | Lee OW et al. | β | 2023 | β |
| Targeted sequencing of the 9p21.3 region reveals association with reduced disease risks in Ashkenazi Jewish centenarians. | Zhu Y et al. | β | 2023 | β |
| Tea intake and risk of kidney stones: A mendelian randomization study. | Liu D et al. | β | 2023 | β |
| The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Colon Cancer: A Study in Mice and Humans. | Iden JA et al. | β | 2023 | β |
| The association of genetic factors with serum calretinin levels in asbestos-related diseases. | Zupanc C et al. | β | 2023 | β |
| The effects of coagulation factors on the risk of endometriosis: a Mendelian randomization study. | Li Y et al. | β | 2023 | β |
| The <i>HLA-B*57:01</i> allele corresponds to a very large <i>MHC</i> haploblock likely explaining its massive effect for HIV-1 elite control. | Rahmouni M et al. | β | 2023 | β |
| Variants of <i>IFNL4</i> Gene in Amazonian and Northern Brazilian Populations. | Angelim CC et al. | β | 2023 | β |
| Vitamin D Levels and Risk of Juvenile Idiopathic Arthritis: A Mendelian Randomization Study. | Clarke SLN et al. | β | 2023 | β |
| Whole-exome sequence analysis of anthropometric traits illustrates challenges in identifying effects of rare genetic variants. | Young KL et al. | β | 2023 | β |
| X-Chromosome Association Study in Latin American Cohorts Identifies New Loci in Parkinson's Disease. | Leal TP et al. | β | 2023 | β |
| X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study. | Hayden LP et al. | β | 2023 | β |
| 3D chromatin maps of the human pancreas reveal lineage-specific regulatory architecture of T2D risk. | Su C et al. | β | 2022 | β |
| Absence of causal association between Vitamin D and bone mineral density across the lifespan: a Mendelian randomization study. | Tang Y et al. | β | 2022 | β |
| Accuracy and applications of sequencing and genotyping approaches for CYP2A6 and homologous genes. | Langlois AWR et al. | β | 2022 | β |
| A comprehensive in silico exploration of the impacts of missense variants on two different conformations of human pirin protein. | Khan AS et al. | β | 2022 | β |
| Admixture Mapping of Sepsis in European Individuals With African Ancestries. | Hernandez-Beeftink T et al. | β | 2022 | β |
| A founder event causing a dominant childhood epilepsy survives 800 years through weak selective pressure. | Grinton BE et al. | β | 2022 | β |
| A Genetic Association Test Accounting for Skewed X-Inactivation With Application to Biotherapy Immunogenicity in Patients With Autoimmune Diseases. | HΓ€ssler S et al. | β | 2022 | β |
| A genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci. | Kimbrel NA et al. | β | 2022 | β |
| A hidden layer of structural variation in transposable elements reveals potential genetic modifiers in human disease-risk loci. | van Bree EJ et al. | β | 2022 | β |
| Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer's and Parkinson's disease. | Gok M et al. | β | 2022 | β |
| A minority of somatically mutated genes in pre-existing fatty liver disease have prognostic importance in the development of NAFLD. | Mann JP et al. | β | 2022 | β |
| Analysis of <i>CACNA1C</i> and <i>KCNH2</i> Risk Variants on Cardiac Autonomic Function in Patients with Schizophrenia. | Refisch A et al. | β | 2022 | β |
| An integrated genome and phenome-wide association study approach to understanding Alzheimer's disease predisposition. | Khaire AS et al. | β | 2022 | β |
| A polygenic approach to the association between smoking and schizophrenia. | Al-Soufi L et al. | β | 2022 | β |
| Appraising the Causal Association between Systemic Iron Status and Heart Failure Risk: A Mendelian Randomisation Study. | Wang X et al. | β | 2022 | β |
| A probable <i>cis</i>-acting genetic modifier of Huntington disease frequent in individuals with African ancestry. | Dawson J et al. | β | 2022 | β |
| A Rare <i>MSH2</i> Variant as a Candidate Marker for Lynch Syndrome II Screening in Tunisia: A Case of Diffuse Gastric Carcinoma. | Kabbage M et al. | β | 2022 | β |
| A Role of DNA Methylation within the CYP17A1 Gene in the Association of Genetic and Environmental Risk Factors with Stress-Related Manifestations of Schizophrenia. | Alfimova M et al. | β | 2022 | β |
| Association between WWOX/MAF variants and dementia-related neuropathologic endophenotypes. | Dugan AJ et al. | β | 2022 | β |
| Association of <i>IGF1</i> polymorphisms with exotropia in a Pakistani cohort. | Zehra Z et al. | β | 2022 | β |
| Association of MMP1 and MMP3 haplotypes with myocardial infarction and echocardiographic parameters of the left ventricle. | Djuric T et al. | β | 2022 | β |
| Association of OPG and RANKL gene polymorphisms with bone mineral density in Indian women. | Nair S et al. | β | 2022 | β |
| Associations between the <i>C3orf20</i> rs12496846 Polymorphism and Both Postoperative Analgesia after Orthognathic and Abdominal Surgeries and <i>C3orf20</i> Gene Expression in the Brain. | Nishizawa D et al. | β | 2022 | β |
| A year of COVID-19 GWAS results from the GRASP portal reveals potential genetic risk factors. | Thibord F et al. | β | 2022 | β |
| Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients. | Quintanilha JCF et al. | β | 2022 | β |
| Birthweight, BMI in adulthood and latent autoimmune diabetes in adults: a Mendelian randomisation study. | Wei Y et al. | β | 2022 | β |
| Brain-specific genes contribute to chronic but not to acute back pain. | Bortsov AV et al. | β | 2022 | β |
| Causal associations between CD40/CD40L and aortic diseases: A mendelian randomization study. | Cui X et al. | β | 2022 | β |
| Causal Associations between Paternal Longevity and Risks of Cardiovascular Diseases. | Hu M et al. | β | 2022 | β |
| Causal associations between sleep traits and four cardiac diseases: a Mendelian randomization study. | Yang Y et al. | β | 2022 | β |
| Causal effects of circulating cytokine concentrations on risk of Alzheimer's disease and cognitive function. | Pagoni P et al. | β | 2022 | β |
| Causal Effects of Circulating Cytokines on the Risk of Psoriasis Vulgaris: A Mendelian Randomization Study. | Zhao P et al. | β | 2022 | β |
| Causal relationships between inflammatory factors and multiple myeloma: A bidirectional Mendelian randomization study. | Wang Q et al. | β | 2022 | β |
| Circadian clock gene variants and their link with chronotype, chrononutrition, sleeping patterns and obesity in the European prospective investigation into cancer and nutrition (EPIC) study. | Molina-Montes E et al. | β | 2022 | β |
| Circulating Soluble CD163, Associations With Cardiovascular Outcomes and Mortality, and Identification of Genetic Variants in Older Individuals: The Cardiovascular Health Study. | Durda P et al. | β | 2022 | β |
| Clotting factor genes are associated with preeclampsia in high-altitude pregnant women in the Peruvian Andes. | Nieves-ColΓ³n MA et al. | β | 2022 | β |
| Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries. | Ε koriΔ-MilosavljeviΔ D et al. | β | 2022 | β |
| Common genetic variation in KATNAL1 non-coding regions is involved in the susceptibility to severe phenotypes of male infertility. | CervΓ‘n-MartΓn M et al. | β | 2022 | β |
| Common huntingtin-related genetic variation is associated with neurobiological and aging traits in humans. | Slike AN et al. | β | 2022 | β |
| Common variants of <i>RARRES2</i> and <i>RETN</i> contribute to susceptibility to hand osteoarthritis and related pain. | Yan S et al. | β | 2022 | β |
| Common Variation in the PIN1 Locus Increases the Genetic Risk to Suffer from Sertoli Cell-Only Syndrome. | CervΓ‘n-MartΓn M et al. | β | 2022 | β |
| Complex interactions between p.His558Arg and linked variants in the sodium voltage-gated channel alpha subunit 5 (Na <i><sub>V</sub></i> 1.5). | Lopes-Marques M et al. | β | 2022 | β |
| Composite CYP3A phenotypes influence tacrolimus dose-adjusted concentration in lung transplant recipients. | Liu M et al. | β | 2022 | β |
| Concurrent outcomes from multiple approaches of epistasis analysis for human body mass index associated loci provide insights into obesity biology. | D'Silva S et al. | β | 2022 | β |
| Contribution of common and rare genetic variants in CEP72 on vincristine-induced peripheral neuropathy in brain tumour patients. | Klumpers MJ et al. | β | 2022 | β |
| Contribution of <i>TEX15</i> genetic variants to the risk of developing severe non-obstructive oligozoospermia. | GuzmΓ‘n-JimΓ©nez A et al. | β | 2022 | β |
| COVID-19 and platelet traits: A bidirectional Mendelian randomization study. | Cheung CL et al. | β | 2022 | β |
| Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. | Byun J et al. | β | 2022 | β |
| Cumulative evidence for associations between genetic variants in interleukin 17 family gene and risk of human diseases. | Liu T et al. | β | 2022 | β |
| Cumulative Evidence for Relationships Between Multiple Variants in the TERT and CLPTM1L Region and Risk of Cancer and Non-Cancer Disease. | Tian J et al. | β | 2022 | β |
| Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study. | Domenighetti C et al. | β | 2022 | β |
| Damaging missense variants in <i>IGF1R</i> implicate a role for IGF-1 resistance in the etiology of type 2 diabetes. | Gardner EJ et al. | β | 2022 | β |
| DDX58 Is Associated With Susceptibility to Severe Influenza Virus Infection in Children and Adolescents. | Lee S et al. | β | 2022 | β |
| Deconstructing a Syndrome: Genomic Insights Into PCOS Causal Mechanisms and Classification. | Dapas M et al. | β | 2022 | β |
| Development and validation of polygenic risk scores for prediction of breast cancer and breast cancer subtypes in Chinese women. | Hou C et al. | β | 2022 | β |
| echolocatoR: an automated end-to-end statistical and functional genomic fine-mapping pipeline. | Schilder BM et al. | β | 2022 | β |
| Effect of Cheese Intake on Cardiovascular Diseases and Cardiovascular Biomarkers. | Hu MJ et al. | β | 2022 | β |
| Efficient approaches for large-scale GWAS with genotype uncertainty. | JΓΈrsboe E et al. | β | 2022 | β |
| Endogenous DHEAS Is Causally Linked With Lumbar Spine Bone Mineral Density and Forearm Fractures in Women. | Quester J et al. | β | 2022 | β |
| Epidemiological evidence for associations between variants in CHRNA genes and risk of lung cancer and chronic obstructive pulmonary disease. | Yang L et al. | β | 2022 | β |
| Epigenomic and Transcriptomic Prioritization of Candidate Obesity-Risk Regulatory GWAS SNPs. | Zhang X et al. | β | 2022 | β |
| Estimating the causal effect of frailty index on vestibular disorders: A two-sample Mendelian randomization. | Xiao G et al. | β | 2022 | β |
| Evaluating a Causal Relationship between Complement Factor I Protein Level and Advanced Age-Related Macular Degeneration Using Mendelian Randomization. | Jones AV et al. | β | 2022 | β |
| Evaluating the association of TRPA1 gene polymorphisms with pain sensitivity: a protocol for an adaptive recall by genotype study. | Nickerson AP et al. | β | 2022 | β |
| Evidence of a Causal Link Between the Well-Being Spectrum and the Risk of Myocardial Infarction: A Mendelian Randomization Study. | Rukh G et al. | β | 2022 | β |
| Exploring causal correlations between inflammatory cytokines and systemic lupus erythematosus: A Mendelian randomization. | Xiang M et al. | β | 2022 | β |
| Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease. | Pagoni P et al. | β | 2022 | β |
| FADS1 rs174550 genotype and high linoleic acid diet modify plasma PUFA phospholipids in a dietary intervention study. | Meuronen T et al. | β | 2022 | β |
| Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight. | Thompson WD et al. | β | 2022 | β |
| Fetal hemoglobin modulates neurocognitive performance in sickle cell anemia<sup>β°,β°β°</sup>. | Heitzer AM et al. | β | 2022 | β |
| Flashfm-ivis: interactive visualization for fine-mapping of multiple quantitative traits. | Zhou F et al. | β | 2022 | β |
| Functional noncoding SNPs in human endothelial cells fine-map vascular trait associations. | Toropainen A et al. | β | 2022 | β |
| Gene-Environment Interactions in Vitamin D Status and Sun Exposure: A Systematic Review with Recommendations for Future Research. | Shraim R et al. | β | 2022 | β |
| Gene-gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer. | Rosenberger A et al. | β | 2022 | β |
| General intelligence and executive functioning are overlapping but separable at genetic and molecular pathway levels: An analytical review of existing GWAS findings. | Ciobanu LG et al. | β | 2022 | β |
| Genetically Predicted Cardiac Troponin I Concentrations and Risk of Stroke and Atrial Fibrillation. | Liu D et al. | β | 2022 | β |
| Genetic analysis of right heart structure and function in 40,000 people. | Pirruccello JP et al. | β | 2022 | β |
| Genetic architecture of RNA editing regulation in Alzheimer's disease across diverse ancestral populations. | Gardner OK et al. | β | 2022 | β |
| Genetic Association Analysis of Anti-VEGF Treatment Response in Neovascular Age-Related Macular Degeneration. | Strunz T et al. | β | 2022 | β |
| Genetic effects of iron levels on liver injury and risk of liver diseases: A two-sample Mendelian randomization analysis. | Wang K et al. | β | 2022 | β |
| Genetic Factors for Coronary Heart Disease and Their Mechanisms: A Meta-Analysis and Comprehensive Review of Common Variants from Genome-Wide Association Studies. | Zarkasi KA et al. | β | 2022 | β |
| Genetic Markers of Atopic Dermatitis Risk for Screening Aviation Applicants. | Gregory ID et al. | β | 2022 | β |
| Genetic risk variants for multiple sclerosis are linked to differences in alternative pre-mRNA splicing. | Putscher E et al. | β | 2022 | β |
| Genetic variation in sodium glucose co-transporter 1 and cardiac structure and function at middle age. | Bavishi A et al. | β | 2022 | β |
| Genetic variation rs1121980 in the fat mass and obesity-associated gene (<i>FTO</i>) is associated with dietary intake in Koreans. | Goh Y et al. | β | 2022 | β |
| Genome-wide analysis identified abundant genetic modulators of contributions of the apolipoprotein E alleles to Alzheimer's disease risk. | Nazarian A et al. | β | 2022 | β |
| Genome-wide analysis of genetic predisposition to common polygenic cancers. | Nazarian A et al. | β | 2022 | β |
| Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility. | Barc J et al. | β | 2022 | β |
| Genome-wide association analyses of common infections in a large practice-based biobank. | Jiang L et al. | β | 2022 | β |
| Genome-wide association studies identify novel genetic loci for epigenetic age acceleration among survivors of childhood cancer. | Dong Q et al. | β | 2022 | β |
| Genome-wide association studies of survival in 1520 cancer patients treated with bevacizumab-containing regimens. | Quintanilha JCF et al. | β | 2022 | β |
| Genome-Wide Association Study for eGFR in a Taiwanese Population. | Chen YC et al. | β | 2022 | β |
| Genome-Wide Association Study of Alzheimer's Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery Dataset. | Homann J et al. | β | 2022 | β |
| Genome-wide association study of aromatase inhibitor discontinuation due to musculoskeletal symptoms. | Hertz DL et al. | β | 2022 | β |
| Genome-Wide Association Study of COVID-19 Outcomes Reveals Novel Host Genetic Risk Loci in the Serbian Population. | Zecevic M et al. | β | 2022 | β |
| Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects. | Krohn L et al. | β | 2022 | β |
| Genomewide Association Study of Retinal Traits in the Amish Reveals Loci Influencing Drusen Development and Link to Age-Related Macular Degeneration. | Osterman MD et al. | β | 2022 | β |
| Genome-wide association study on 13β167 individuals identifies regulators of blood CD34+cell levels. | Lopez de Lapuente Portilla A et al. | β | 2022 | β |
| Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors. | Moore A et al. | β | 2022 | β |
| Genome-wide Survival Analysis for Macular Neovascularization Development in Central Serous Chorioretinopathy Revealed Shared Genetic Susceptibility with Polypoidal Choroidal Vasculopathy. | Mori Y et al. | β | 2022 | β |
| Genotyping of <i>UGT1A1*</i>80 as an Alternative to <i>UGT1A1*</i>28 Genotyping in Spain. | Bravo-GΓ³mez A et al. | β | 2022 | β |
| Germline-somatic JAK2 interactions are associated with clonal expansion in myelofibrosis. | Brown DW et al. | β | 2022 | β |
| High-resolution genome topology of human retina uncovers super enhancer-promoter interactions at tissue-specific and multifactorial disease loci. | Marchal C et al. | β | 2022 | β |
| Human intelectin-2 (ITLN2) is selectively expressed by secretory Paneth cells. | Nonnecke EB et al. | β | 2022 | β |
| Identification of 4 New Loci Associated With Primary Hyperparathyroidism (PHPT) and a Polygenic Risk Score for PHPT. | Soto-Pedre E et al. | β | 2022 | β |
| Identification of a Germline Pyrin Variant in a Metastatic Melanoma Patient With Multiple Spontaneous Regressions and Immune-related Adverse Events. | Oswalt CJ et al. | β | 2022 | β |
| Identification of a novel genetic locus associated with immune-mediated thrombotic thrombocytopenic purpura. | Stubbs MJ et al. | β | 2022 | β |
| Identification of Genetic Networks Reveals Complex Associations and Risk Trajectory Linking Mild Cognitive Impairment to Alzheimer's Disease. | Strafella C et al. | β | 2022 | β |
| Identification of genetic risk loci for depression and migraine comorbidity in Han Chinese residing in Taiwan. | Tsai MC et al. | β | 2022 | β |
| Identification of Novel Loci Involved in Adalimumab Response in Crohn's Disease Patients Using Integration of Genome Profiling and Isoform-Level Immune-Cell Deconvoluted Transcriptome Profiling of Colon Tissue. | Gorenjak M et al. | β | 2022 | β |
| Immune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility. | CervΓ‘n-MartΓn M et al. | β | 2022 | β |
| Implementation of CYP2D6 copy-number imputation panel and frequency of key pharmacogenetic variants in Finnish individuals with a psychotic disorder. | HΓ€kkinen K et al. | β | 2022 | β |
| Implication of genetic variants in primary microRNA processing sites in the risk of multiple sclerosis. | Hecker M et al. | β | 2022 | β |
| Influence of NOS1AP Risk Variants on the Corrected QT (QTc) Interval in the Pharmacotherapy of Schizophrenia. | Esen D et al. | β | 2022 | β |
| Insulin Response to Oral Glucose and Cardiometabolic Disease: A Mendelian Randomization Study to Assess Potential Causality. | Nguyen A et al. | β | 2022 | β |
| Integrating convolution and self-attention improves language model of human genome for interpreting non-coding regions at base-resolution. | Yang M et al. | β | 2022 | β |
| Integration of DNA sequencing with population pharmacokinetics to improve the prediction of irinotecan exposure in cancer patients. | Karas S et al. | β | 2022 | β |
| Investigating Causal Associations of Diet-Derived Circulating Antioxidants with the Risk of Digestive System Cancers: A Mendelian Randomization Study. | Zhang X et al. | β | 2022 | β |
| Investigating DNA methylation as a mediator of genetic risk in childhood acute lymphoblastic leukemia. | Xu K et al. | β | 2022 | β |
| Investigating the genetic architecture of eye colour in a Canadian cohort. | Lona-Durazo F et al. | β | 2022 | β |
| Investigation of clinical characteristics and genome associations in the 'UK Lipoedema' cohort. | Grigoriadis D et al. | β | 2022 | β |
| Iron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization study. | Mohus RM et al. | β | 2022 | β |
| Is Hearing Impairment Causally Associated With Falls? Evidence From a Two-Sample Mendelian Randomization Study. | Wang J et al. | β | 2022 | β |
| Is there a causal relationship between executive function and liability to mental health and substance use? A Mendelian randomization approach. | Burton SMI et al. | β | 2022 | β |
| KDR genetic predictor of toxicities induced by sorafenib and regorafenib. | Quintanilha JCF et al. | β | 2022 | β |
| Leveraging global multi-ancestry meta-analysis in the study of idiopathic pulmonary fibrosis genetics. | Partanen JJ et al. | β | 2022 | β |
| Lipid-lowering drug targets and Parkinson's disease: A sex-specific Mendelian randomization study. | Zhao Y et al. | β | 2022 | β |
| Low Intelligence Predicts Higher Risks of Coronary Artery Disease and Myocardial Infarction: Evidence From Mendelian Randomization Study. | Yang F et al. | β | 2022 | β |
| <i>APOE</i> alleles modulate associations of plasma metabolites with variants from multiple genes on chromosome 19q13.3. | Nazarian A et al. | β | 2022 | β |
| Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease. | Domenighetti C et al. | β | 2022 | β |
| Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk. | D'Urso S et al. | β | 2022 | β |
| Migraine, Stroke, and Cervical Arterial Dissection: Shared Genetics for a Triad of Brain Disorders With Vascular Involvement. | Daghlas I et al. | β | 2022 | β |
| Misaligned sequencing reads from the GNAQ-pseudogene locus may yield GNAQ artefact variants. | Lim JQ et al. | β | 2022 | β |
| Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19. | Huffman JE et al. | β | 2022 | β |
| Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity. | Zhang S et al. | β | 2022 | β |
| Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations. | Temprano-Sagrera G et al. | β | 2022 | β |
| Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities. | Katsumata Y et al. | β | 2022 | β |
| Multivariate, region-based genetic analyses of facets of reproductive aging in White and Black women. | Bielak LF et al. | β | 2022 | β |
| Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma. | Yasumizu Y et al. | β | 2022 | β |
| Neurogenetics of Dynamic Connectivity Patterns Associated With Obsessive-Compulsive Symptoms in Healthy Children. | SuΓ±ol M et al. | β | 2022 | β |
| New Insight into the human genetic diversity in North African populations by genotyping of SNPs in DRD3, CSMD1 and NRG1 genes. | Mestiri S et al. | β | 2022 | β |
| Nonsynonymous amino acid changes in the Ξ±-chain of complement component 5 influence longitudinal susceptibility to <i>Plasmodium falciparum</i> infections and severe malarial anemia in kenyan children. | Raballah E et al. | β | 2022 | β |
| Oxytocin and vasotocin receptor variation and the evolution of human prosociality. | Theofanopoulou C et al. | β | 2022 | β |
| Pancan-MNVQTLdb: systematic identification of multi-nucleotide variantΒ quantitative trait loci in 33 cancer types. | Wang D et al. | β | 2022 | β |
| Periodontitis Risk Variants at <i>SIGLEC5</i> Impair ERG and MAFB Binding. | Mueller R et al. | β | 2022 | β |
| PIK3R5 genetic predictors of hypertension induced by VEGF-pathway inhibitors. | Quintanilha JCF et al. | β | 2022 | β |
| Polygenic mechanisms underpinning the response to exercise-induced muscle damage in humans: In vivo and in vitro evidence. | Baumert P et al. | β | 2022 | β |
| Polygenic risk of paclitaxel-induced peripheral neuropathy: a genome-wide association study. | Hooshmand K et al. | β | 2022 | β |
| Polymorphic Variants of the <i>PDGFRB</i> Gene Influence Efficacy of PRP Therapy in Treating Tennis Elbow: A Prospective Cohort Study. | Szyluk K et al. | β | 2022 | β |
| Polymorphisms in ERCC4 and ERCC5 and risk of cancers: Systematic research synopsis, meta-analysis, and epidemiological evidence. | Zuo C et al. | β | 2022 | β |
| Polymorphisms of the 11q23.3 Locus Affect the Risk and Mortality of Coronary Artery Disease. | Iwanicki T et al. | β | 2022 | β |
| Positive selection acts on regulatory genetic variants in populations of European ancestry that affect ALDH2 gene expression. | Schaschl H et al. | β | 2022 | β |
| Predicting Dihydropyrimidine Dehydrogenase Deficiency and Related 5-Fluorouracil Toxicity: Opportunities and Challenges of <i>DPYD</i> Exon Sequencing and the Role of Phenotyping Assays. | De Luca O et al. | β | 2022 | β |
| Prioritization and functional analysis of GWAS risk loci for Barrett's esophagus and esophageal adenocarcinoma. | Chen J et al. | β | 2022 | β |
| Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19. | Palmos AB et al. | β | 2022 | β |
| PTBP2 - a gene with relevance for both Anorexia nervosa and body weight regulation. | Zheng Y et al. | β | 2022 | β |
| Rare variant association study of veteran twin whole-genomes links severe depression with a nonsynonymous change in the neuronal gene <i>BHLHE22</i>. | Hupalo D et al. | β | 2022 | β |
| Recessive Genome-Wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes. | O'Connor MJ et al. | β | 2022 | β |
| Relationship between genetically determined telomere length and glioma risk. | Saunders CN et al. | β | 2022 | β |
| rs2013278 in the multiple immunological-trait susceptibility locus CD28 regulates the production of non-functional splicing isoforms. | Hitomi Y et al. | β | 2022 | β |
| rs9459874 and rs1012656 in CCR6/FGFR1OP confer susceptibility to primary biliary cholangitis. | Hitomi Y et al. | β | 2022 | β |
| Selecting Genetic Variants and Interactions Associated with Amyotrophic Lateral Sclerosis: A Group LASSO Approach. | Feronato SG et al. | β | 2022 | β |
| Smoking, alcohol consumption, and age at onset of Huntington's disease: a Mendelian randomization study. | Wang M et al. | β | 2022 | β |
| STAT3-mediated allelic imbalance of novel genetic variant Rs1047643 and B-cell-specific super-enhancer in association with systemic lupus erythematosus. | Zhang Y et al. | β | 2022 | β |
| Telomere Length and COVID-19 Outcomes: A Two-Sample Bidirectional Mendelian Randomization Study. | Jiang L et al. | β | 2022 | β |
| Telomere length is causally connected to brain MRI image derived phenotypes: A mendelian randomization study. | Salih A et al. | β | 2022 | β |
| The APOE locus is linked to decline in general cognitive function: 20-years follow-up in the Doetinchem Cohort Study. | Rietman ML et al. | β | 2022 | β |
| The association of <i>ARRB1</i> polymorphisms with response to antidepressant treatment in depressed patients. | Chappell K et al. | β | 2022 | β |
| The Effect of Circulating Zinc, Selenium, Copper and Vitamin K<sub>1</sub> on COVID-19 Outcomes: A Mendelian Randomization Study. | Sobczyk MK et al. | β | 2022 | β |
| The genetic landscape of major drug metabolizing cytochrome P450 genes-an updated analysis of population-scale sequencing data. | Zhou Y et al. | β | 2022 | β |
| The lack of association between PADI4_94 or PADI4_104 polymorphisms and RF, ACPA and anti-PAD4 in patients with rheumatoid arthritis. | Ciesla M et al. | β | 2022 | β |
| The role of IFNL4 in liver inflammation and progression of fibrosis. | MΓΈhlenberg M et al. | β | 2022 | β |
| TIMP2 genetic variation rs4789932 may associate with anΒ increased risk of developing acne scarring based on a case-control study of Chinese Han population. | Wen X et al. | β | 2022 | β |
| TOP-LD: A tool to explore linkage disequilibrium with TOPMed whole-genome sequence data. | Huang L et al. | β | 2022 | β |
| Towards Personalized Allele-Specific Antisense Oligonucleotide Therapies for Toxic Gain-of-Function Neurodegenerative Diseases. | Helm J et al. | β | 2022 | β |
| Trans-interaction of risk loci 6p24.1 and 10q11.21 is associated with endothelial damage in coronary artery disease. | Tay KY et al. | β | 2022 | β |
| Trypsinogen (PRSS1 and PRSS2) gene dosage correlates with pancreatitis risk across genetic and transgenic studies: a systematic review and re-analysis. | Zou WB et al. | β | 2022 | β |
| Two distinct mechanisms underlie estrogen-receptor-negative breast cancer susceptibility at the 2p23.2 locus. | Mendoza-FandiΓ±o G et al. | β | 2022 | β |
| UACA locus is associated with breast cancer chemoresistance and survival. | Zhu Q et al. | β | 2022 | β |
| Unbiased metabolome screen leads to personalized medicine strategy for amyotrophic lateral sclerosis. | Boddy S et al. | β | 2022 | β |
| Unbiased metabolome screen links serum urate to risk of Alzheimer's disease. | ΕanlΔ± BA et al. | β | 2022 | β |
| Urinary Sodium Excretion Enhances the Effect of Alcohol on Blood Pressure. | Jiang X et al. | β | 2022 | β |
| Variants in the <i>GPR146</i> Gene Are Associated With a Favorable Cardiometabolic Risk Profile. | Rimbert A et al. | β | 2022 | β |
| Vitamin D Deficiency and COVID-19: A Biological Database Study on Pathways and Gene-Disease Associations. | AlcalΓ‘-Santiago Γ et al. | β | 2022 | β |
| Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease. | Katz DH et al. | β | 2022 | β |
| A 3D structural SARS-CoV-2-human interactome to explore genetic and drug perturbations. | Wierbowski SD et al. | β | 2021 | β |
| Achievements and Challenges of Genomics-Assisted Breeding in Forest Trees: From Marker-Assisted Selection to Genome Editing. | Ahmar S et al. | β | 2021 | β |
| A comprehensive integrated post-GWAS analysis of Type 1 diabetes reveals enhancer-based immune dysregulation. | Kim SS et al. | β | 2021 | β |
| Admixture with indigenous people helps local adaptation: admixture-enabled selection in Polynesians. | Isshiki M et al. | β | 2021 | β |
| A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene. | Magusali N et al. | β | 2021 | β |
| A GWAS top hit for circulating leptin is associated with weight gain but not with leptin protein levels in lithium-augmented patients with major depression. | Bopp SK et al. | β | 2021 | β |
| A Model of Minor Histocompatibility Antigens in Allogeneic Hematopoietic Cell Transplantation. | Martin PJ et al. | β | 2021 | β |
| Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study. | Dugan AJ et al. | β | 2021 | β |
| An assessment of the effect of the genotype on postoperative venous thromboembolism risk in 140,831 surgical patients. | A Christensen M et al. | β | 2021 | β |
| An association study in the Taiwan Biobank elicits the GABAA receptor genes GABRB3, GABRA5, and GABRG3 as candidate loci for sleep duration in the Taiwanese population. | Hou SJ et al. | β | 2021 | β |
| An immunogenetic view of COVID-19. | Aguiar VRC et al. | β | 2021 | β |
| A Role of Variance in Interferon Genes to Disease Severity in COVID-19 Patients. | Gozman L et al. | β | 2021 | β |
| Assessing the association of common genetic variants in EPHB4 and RASA1 with phenotype severity in familial cerebral cavernous malformation. | Choksi F et al. | β | 2021 | β |
| Association of Genes of the NO Pathway with Altitude Disease and Hypoxic Pulmonary Hypertension. | Hannemann J et al. | β | 2021 | β |
| Association of Genetic Variants With Body-Mass Index and Blood Pressure in Adolescents: A Replication Study. | Goulet D et al. | β | 2021 | β |
| Blood pressure and risk of cancer: a Mendelian randomization study. | Chan II et al. | β | 2021 | β |
| Common Genetic Aberrations Associated with Metabolic Interferences in Human Type-2 Diabetes and Acute Myeloid Leukemia: A Bioinformatics Approach. | Kyriakou TC et al. | β | 2021 | β |
| Effect of n-3 polyunsaturated fatty acids on ischemic heart disease and cardiometabolic risk factors: a two-sample Mendelian randomization study. | Xu B et al. | β | 2021 | β |
| Evaluation of low-pass genome sequencing in polygenic risk score calculation for Parkinson's disease. | Kim S et al. | β | 2021 | β |
| Genetic ablation of Gpnmb does not alter synuclein-related pathology. | Brendza R et al. | β | 2021 | β |
| Genetic meta-analysis of twin birth weight shows high genetic correlation with singleton birth weight. | Beck JJ et al. | β | 2021 | β |
| Genetic Predisposition to Mosaic Chromosomal Loss Is Associated With Functional Outcome After Ischemic Stroke. | Johansson M et al. | β | 2021 | β |
| Gene-Toxicant Interactions in Gulf War Illness: Differential Effects of the <i>PON1</i> Genotype. | Vahey J et al. | β | 2021 | β |
| Genome-Wide Association and Mendelian Randomization Analysis Reveal the Causal Relationship Between White Blood Cell Subtypes and Asthma in Africans. | Soremekun O et al. | β | 2021 | β |
| Genome-wide association study of hospitalized COVID-19 patients in the United Arab Emirates. | Mousa M et al. | β | 2021 | β |
| Gluten-free Diet Reduces the Risk of Irritable Bowel Syndrome: A Mendelian Randomization Analysis. | Sun Y et al. | β | 2021 | β |
| GWAS loci associated with Chagas cardiomyopathy influences DNA methylation levels. | Casares-Marfil D et al. | β | 2021 | β |
| Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals. | Sha Z et al. | β | 2021 | β |
| Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies. | JuliΓ‘n-Serrano S et al. | β | 2021 | β |
| Herpesvirus infections and Alzheimer's disease: a Mendelian randomization study. | Huang SY et al. | β | 2021 | β |
| Inferred expression regulator activities suggest genes mediating cardiometabolic genetic signals. | Hoskins JW et al. | β | 2021 | β |
| Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk loci. | King HW et al. | β | 2021 | β |
| Integrative assessment of CIP2A overexpression and mutational effects in human malignancies identifies possible deleterious variants. | Tarek MM et al. | β | 2021 | β |
| IRF2BP2 3'UTR Polymorphism Increases Coronary Artery Calcification in Men. | Vilmundarson RO et al. | β | 2021 | β |
| <i>STXBP6</i> and <i>B3GNT6</i> Genes are Associated With Selective IgA Deficiency. | Lim CK et al. | β | 2021 | β |
| Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating <i>TERT via</i> Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC. | Dong X et al. | β | 2021 | β |
| LDexpress: an online tool for integrating population-specific linkage disequilibrium patterns with tissue-specific expression data. | Lin SH et al. | β | 2021 | β |
| Life-Threatening Docetaxel Toxicity in a Patient With Reduced-Function CYP3A Variants: A Case Report. | Powell NR et al. | β | 2021 | β |
| Low Plasma Adiponectin in Risk of Type 2 Diabetes: Observational Analysis and One- and Two-Sample Mendelian Randomization Analyses in 756,219 Individuals. | Nielsen MB et al. | β | 2021 | β |
| Machine Learning Identifies Six Genetic Variants and Alterations in the Heart Atrial Appendage as Key Contributors to PD Risk Predictivity. | Ho D et al. | β | 2021 | β |
| Mendelian randomization study on atrial fibrillation and cardiovascular disease subtypes. | Kwok MK et al. | β | 2021 | β |
| Meta-analyses identify DNA methylation associated with kidney function and damage. | Schlosser P et al. | β | 2021 | β |
| Mutations and variants of ONECUT1 in diabetes. | Philippi A et al. | β | 2021 | β |
| Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function. | Yang T et al. | β | 2021 | β |
| Relationship Between Serum Amino Acid Levels and Bone Mineral Density: A Mendelian Randomization Study. | Cui Z et al. | β | 2021 | β |
| Revisiting genetic artifacts on DNA methylation microarrays exposes novel biological implications. | Planterose JimΓ©nez B et al. | β | 2021 | β |
| Single Nucleotide Polymorphisms in CD36 Are Associated with Macular Pigment among Children. | Liu R et al. | β | 2021 | β |
| Stroke and Myocardial Infarction: A Bidirectional Mendelian Randomization Study. | Sun W et al. | β | 2021 | β |
| The genetic case for cardiorespiratory fitness as a clinical vital sign and the routine prescription of physical activity in healthcare. | Hanscombe KB et al. | β | 2021 | β |
| The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes. | Sharp RC et al. | β | 2021 | β |
| The power of genetic diversity in genome-wide association studies of lipids. | Graham SE et al. | β | 2021 | β |
| The total and direct effects of systolic and diastolic blood pressure on cardiovascular disease and longevity using Mendelian randomisation. | Chan II et al. | β | 2021 | β |
| Tracing the Evolution of Human Gene Regulation and Its Association with Shifts in Environment. | Colbran LL et al. | β | 2021 | β |
| Translational Analysis of Moderate to Severe Asthma GWAS Signals Into Candidate Causal Genes and Their Functional, Tissue-Dependent and Disease-Related Associations. | Portelli MA et al. | β | 2021 | β |
| WEVar: a novel statistical learning framework for predicting noncoding regulatory variants. | Wang Y et al. | β | 2021 | β |