Chronic alcoholism and the frontal lobe: which executive functions are imparied?
paper
Cited
Public
Unavailable
- Authors
- Ratti, M T; Bo, P; Giardini, A; Soragna, D
- Year
- 2002
- Journal
- Acta neurologica Scandinavica
- PMID
- 11939939
- DOI
- 10.1034/j.1600-0404.2002.0o315.x
OBJECTIVE: Over the last decade, various hypotheses have been advanced concerning the cognitive functions affected by chronic alcoholism. The aim of this study was to identify the pattern of executive function impairment in chronic alcoholism, shedding light on possible differences between specific functions related to the frontal lobe. METHODS: Twenty-two male alcoholics and 22 controls, matched for age, educational level and IQ, were enrolled in the study. MMPI and a battery of neuropsychological tests [i.e. digit symbol, trail making test, Stroop test, digit cancellation test, Wisconsin card sorting test (WCST), simple and choice reaction times] for assessing frontal lobe functioning were administered. RESULTS: The alcoholics were found to be impaired in a wide range of executive domains, with the exception of the Stroop test, which nevertheless showed a trend towards statistically significant differences between patients and controls. CONCLUSION: With the exception of aggression - our subjects did not have high aggression scale scores - the 'frontal lobe hypothesis', according to which alcoholic patients are impaired on function tests related to the frontal lobe, was therefore confirmed in our sample.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Cognitive impairment in alcohol use disorder and clinical practice guidelines for management of long-stay alcohol use disorder patients. | Praharaj SK et al. | β | 2025 | β |
| Episodic memory and inhibitory control in people who inject substances results of cohort COSINUS study. | Lalanne L et al. | β | 2025 | β |
| Alcohol, flexible behavior, and the prefrontal cortex: Functional changes underlying impaired cognitive flexibility. | Nippert KE et al. | β | 2024 | β |
| A Study of the association of neurocognition with relapse and quality of life in patients of alcohol dependence. | Rure D et al. | β | 2024 | β |
| Intrinsic brain functional connectivity patterns in alcohol use disorder. | Maleki N et al. | β | 2022 | β |
| The effects of acamprosate on prefrontal cortical function are mimicked by CaCl2 and they are influenced by the history of alcohol exposure. | Melugin PR et al. | β | 2022 | β |
| Chronic alcohol exposure during critical developmental periods differentially impacts persistence of deficits in cognitive flexibility and related circuitry. | Dannenhoffer CA et al. | β | 2021 | β |
| Externalizing psychopathology and cognitive functions in patients with early- and late-onset alcohol dependence. | Das A et al. | β | 2021 | β |
| Heterogeneity of Executive Function Abilities in Recently Detoxified Patients with Alcohol Use Disorder: Evidence from a Cluster Analysis. | Schmid F et al. | β | 2021 | β |
| Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder. | Spindler C et al. | β | 2021 | β |
| Random Forest Classification of Alcohol Use Disorder Using EEG Source Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures. | Kamarajan C et al. | β | 2020 | β |
| Random Forest Classification of Alcohol Use Disorder Using fMRI Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures. | Kamarajan C et al. | β | 2020 | β |
| Unveiling causal interactions in complex systems. | Stavroglou SK et al. | β | 2020 | β |
| An Event-related Potential Study of Error-monitoring Deficits in Female College Students Who Participate in Binge Drinking. | Kim EH et al. | β | 2019 | β |
| Effectiveness of an Integrated Intervention Program for Alcoholism (IIPA) for enhancing self-regulation: Preliminary evidence. | Kumar R et al. | β | 2019 | β |
| Executive Functioning Moderates Responses to Appetitive Cues: A Study in Severe Alcohol Use Disorder and Alcoholic Liver Disease. | Logge WB et al. | β | 2019 | β |
| Mild Effect of Nalmefene on Alcoholic Cue-Induced Response Invigoration in Alcohol Use Disorder Without Accompanying Changes in Electrophysiological Signatures of Early Visual Processing and Executive Control. | GΓ‘l BI et al. | β | 2019 | β |
| Neural correlates of visual attention in alcohol use disorder. | Zehra A et al. | β | 2019 | β |
| Cognitive deficits in problematic drinkers with and without mild to borderline intellectual disability. | van Duijvenbode N et al. | β | 2018 | β |
| Light social drinkers are more distracted by irrelevant information from an induced attentional bias than heavy social drinkers. | Knight HC et al. | β | 2018 | β |
| Neuropsychological Performance in Alcohol Dependent Patients: A One-Year Longitudinal Study. | Ioime L et al. | β | 2018 | β |
| The efficacy of a working memory training in substance use patients: A randomized double-blind placebo-controlled clinical trial. | Wanmaker S et al. | β | 2018 | β |
| A Complex Interplay of Vitamin B1 and B6 Metabolism with Cognition, Brain Structure, and Functional Connectivity in Older Adults. | Jannusch K et al. | β | 2017 | β |
| Adolescence and Drug Use Vulnerability: Findings from Neuroimaging. | Squeglia LM et al. | β | 2017 | β |
| A neuropsychological study of older adult first-time sex offenders. | Rodriguez M et al. | β | 2017 | β |
| Differential spontaneous recovery across cognitive abilities during detoxification period in alcohol-dependence. | Petit G et al. | β | 2017 | β |
| Diversities of behavioral traits and neuropsychological function in different substance addiction. | Wang HY et al. | β | 2017 | β |
| Dorsolateral prefrontal cortex contributes to the impaired behavioral adaptation in alcohol dependence. | Beylergil SB et al. | β | 2017 | β |
| Executive Functions, Memory, and Social Cognitive Deficits and Recovery in Chronic Alcoholism: A Critical Review to Inform Future Research. | Le Berre AP et al. | β | 2017 | β |
| Frontal lobe executive dysfunction and cerebral perfusion study in alcohol dependence syndrome. | Khanna P et al. | β | 2017 | β |
| Neuropsychological Impairment in Detoxified Alcohol-Dependent Subjects with Preserved Psychosocial Functioning. | Martelli C et al. | β | 2017 | β |
| Can brain games help smokers quit?: Results of a randomized clinical trial. | Loughead J et al. | β | 2016 | β |
| Differential fMRI BOLD responses in amygdala in intermittent explosive disorder as a function of past Alcohol Use Disorder. | Coccaro EF et al. | β | 2016 | β |
| Glutamatergic plasticity and alcohol dependence-induced alterations in reward, affect and cognition. | Burnett EJ et al. | β | 2016 | β |
| Self-awareness of cognitive dysfunction: Self-reported complaints and cognitive performance in patients with alcohol-induced mild or major neurocognitive disorder. | Walvoort SJ et al. | β | 2016 | β |
| An Open-label, Self-control, Prospective Study on Cognitive Function, Academic Performance, and Tolerability of Osmotic-release Oral System Methylphenidate in Children with Attention-deficit Hyperactivity Disorder. | Zheng Y et al. | β | 2015 | β |
| Confounders in the detection of minimal hepatic encephalopathy: a neuropsychological and quantified EEG study. | Campagna F et al. | β | 2015 | β |
| Dendritic remodeling of hippocampal neurons is associated with altered NMDA receptor expression in alcohol dependent rats. | Staples MC et al. | β | 2015 | β |
| Assessment of abstract reasoning abilities in alcohol-dependent subjects: an fMRI study. | Bagga D et al. | β | 2014 | β |
| Chronic alcohol consumption and its effect on nodes of frontocerebellar and limbic circuitry: comparison of effects in France and the United States. | Le Berre AP et al. | β | 2014 | β |
| Cognitive control in alcohol use disorder: deficits and clinical relevance. | Wilcox CE et al. | β | 2014 | β |
| Cognitive impairments in alcohol-dependent subjects. | Bernardin F et al. | β | 2014 | β |
| Evaluation of antidepressant and memory-improving efficacy of aripiprazole and fluoxetine in alcohol-preferring rats. | Burda-Malarz K et al. | β | 2014 | β |
| Evaluation of the antidepressant, anxiolytic and memory-improving efficacy of aripiprazole and fluoxetine in ethanol-treated rats. | Burda-Malarz K et al. | β | 2014 | β |
| Neurocognitive deficits, craving, and abstinence among alcohol-dependent individuals following detoxification. | Naim-Feil J et al. | β | 2014 | β |
| Profiles of impaired, spared, and recovered neuropsychologic processes in alcoholism. | Oscar-Berman M et al. | β | 2014 | β |
| Proteomic approaches and identification of novel therapeutic targets for alcoholism. | Gorini G et al. | β | 2014 | β |
| Translational clinical neuroscience perspectives on the cognitive and neurobiological mechanisms underlying alcohol-related aggression. | Beck A et al. | β | 2014 | β |
| Aerobic exercise moderates the effect of heavy alcohol consumption on white matter damage. | Karoly HC et al. | β | 2013 | β |
| A role for cognitive rehabilitation in increasing the effectiveness of treatment for alcohol use disorders. | Bates ME et al. | β | 2013 | β |
| Brain volumes and neuropsychological performance are related to current smoking and alcoholism history. | Luhar RB et al. | β | 2013 | β |
| Executive functions in adult offspring of alcohol-dependent probands: toward a cognitive endophenotype? | Gierski F et al. | β | 2013 | β |
| Inferring about individual drug and schizotypy effects on cognitive functioning in polydrug using mephedrone users before and after clubbing. | Herzig DA et al. | β | 2013 | β |
| Neuropsychological rehabilitation in alcohol-related brain damage: a systematic review. | Svanberg J et al. | β | 2013 | β |
| Response inhibition toward alcohol-related cues using an alcohol go/no-go task in problem and non-problem drinkers. | Kreusch F et al. | β | 2013 | β |
| Thiamine deficiency induced neurochemical, neuroanatomical, and neuropsychological alterations: a reappraisal. | Nardone R et al. | β | 2013 | β |
| White matter damage is associated with memory decline in chronic alcoholics: a quantitative diffusion tensor tractography study. | Trivedi R et al. | β | 2013 | β |
| Widespread and sustained cognitive deficits in alcoholism: a meta-analysis. | Stavro K et al. | β | 2013 | β |
| Cognitive functions in abstinent alcohol-dependent patients. | Kopera M et al. | β | 2012 | β |
| Learning from positive and negative monetary feedback in patients with alcohol dependence. | Rustemeier M et al. | β | 2012 | β |
| Neurocognitive deficits in male alcoholics: an ERP/sLORETA analysis of the N2 component in an equal probability Go/NoGo task. | Pandey AK et al. | β | 2012 | β |
| Performance on an everyday life activity in persons diagnosed with alcohol dependency compared to healthy controls: relations between a computerized shopping task and cognitive and clinical variables. | Laloyaux J et al. | β | 2012 | β |
| Regional brain structural dysmorphology in human immunodeficiency virus infection: effects of acquired immune deficiency syndrome, alcoholism, and age. | Pfefferbaum A et al. | β | 2012 | β |
| The effects of heavy social drinking on executive function: a systematic review and meta-analytic study of existing literature and new empirical findings. | Montgomery C et al. | β | 2012 | β |
| Alcohol-related amnesia and dementia: animal models have revealed the contributions of different etiological factors on neuropathology, neurochemical dysfunction and cognitive impairment. | Vetreno RP et al. | β | 2011 | β |
| Cognitive and neurobiological mechanisms of alcohol-related aggression. | Heinz AJ et al. | β | 2011 | β |
| Effects of acamprosate on cognition in a treatment study of patients with schizophrenia spectrum disorders and comorbid alcohol dependence. | Ralevski E et al. | β | 2011 | β |
| Effects of chronic intermittent ethanol exposure on orbitofrontal and medial prefrontal cortex-dependent behaviors in mice. | Badanich KA et al. | β | 2011 | β |
| Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening. | Gorini G et al. | β | 2011 | β |
| Neuropsychological functioning in patients with alcohol-related liver disease before and after liver transplantation. | Pegum N et al. | β | 2011 | β |
| Transcriptional control of maladaptive and protective responses in alcoholics: a role of the NF-ΞΊB system. | Yakovleva T et al. | β | 2011 | β |
| What are the specific vs. generalized effects of drugs of abuse on neuropsychological performance? | FernΓ‘ndez-Serrano MJ et al. | β | 2011 | β |
| Effects of alcohol on tests of executive functioning in men and women: a dose response examination. | Guillot CR et al. | β | 2010 | β |
| Impulsivity and executive functions in polysubstance-using rave attenders. | Verdejo-GarcΓa A et al. | β | 2010 | β |
| Prevalence of executive dysfunction in cocaine, heroin and alcohol users enrolled in therapeutic communities. | FernΓ‘ndez-Serrano MJ et al. | β | 2010 | β |
| Why gamblers fail to win: a review of cognitive and neuroimaging findings in pathological gambling. | van Holst RJ et al. | β | 2010 | β |
| A history of alcohol dependence increases the incidence and severity of postoperative cognitive dysfunction in cardiac surgical patients. | Hudetz JA et al. | β | 2009 | β |
| Chronic alcoholism: insights from neurophysiology. | Campanella S et al. | β | 2009 | β |
| From the brain to bad behaviour and back again: neurocognitive and psychobiological mechanisms of driving while impaired by alcohol. | Brown TG et al. | β | 2009 | β |
| Frontal brain dysfunction in alcoholism with and without antisocial personality disorder. | Oscar-Berman M et al. | β | 2009 | β |
| Impaired inhibition of proactive interference in abstinent individuals with alcoholism. | NoΓ«l X et al. | β | 2009 | β |
| Alcohol and estrogen replacement therapy in postmenopausal women. Direct and mediated effects on cognitive component processes. | Tivis LJ et al. | β | 2008 | β |
| Cognitive dysfunctions associated with PTSD: evidence from World War II prisoners of war. | Hart J et al. | β | 2008 | β |
| Decreased volume of the brain reward system in alcoholism. | Makris N et al. | β | 2008 | β |
| Executive dysfunction as a risk marker for substance abuse: the role of impulsive personality traits. | Dolan SL et al. | β | 2008 | β |
| Genetic factors influencing alcohol dependence. | Mayfield RD et al. | β | 2008 | β |
| Predictors of decision-making on the Iowa Gambling Task: independent effects of lifetime history of substance use disorders and performance on the Trail Making Test. | Barry D et al. | β | 2008 | β |
| Recollective experience in alcohol dependence: a laboratory study. | Thoma P et al. | β | 2008 | β |
| Alcohol cues increase cognitive impulsivity in individuals with alcoholism. | NoΓ«l X et al. | β | 2007 | β |
| Alcohol: effects on neurobehavioral functions and the brain. | Oscar-Berman M et al. | β | 2007 | β |
| Brain morphometry and cognitive performance in detoxified alcohol-dependents with preserved psychosocial functioning. | Chanraud S et al. | β | 2007 | β |
| Cognitive function in older diabetic subjects with a history of alcohol abuse. | Hudetz JA et al. | β | 2007 | β |
| Component cognitive and motor processes of the digit symbol test: differential deficits in alcoholism, HIV infection, and their comorbidity. | Sassoon SA et al. | β | 2007 | β |
| Delta and theta oscillations as risk markers in adolescent offspring of alcoholics. | Rangaswamy M et al. | β | 2007 | β |
| Postoperative cognitive dysfunction in older patients with a history of alcohol abuse. | Hudetz JA et al. | β | 2007 | β |
| Response inhibition and cognitive flexibility in schizophrenia with and without comorbid substance use disorder. | Thoma P et al. | β | 2007 | β |
| The influence of alcohol on basic motoric and cognitive disinhibition. | Rose AK et al. | β | 2007 | β |
| Cognitive function and mood in MDMA/THC users, THC users and non-drug using controls. | Lamers CT et al. | β | 2006 | β |
| Comparative gene expression in brain regions of human alcoholics. | Flatscher-Bader T et al. | β | 2006 | β |
| Educational achievement and early school behavior as predictors of alcohol-use disorders: 35-year follow-up of the Woodlawn Study. | Crum RM et al. | β | 2006 | β |
| Event-related oscillations in offspring of alcoholics: neurocognitive disinhibition as a risk for alcoholism. | Kamarajan C et al. | β | 2006 | β |
| Executive function and memory in relation to olfactory deficits in alcohol-dependent patients. | Rupp CI et al. | β | 2006 | β |
| Moderate-to-heavy alcohol intake is associated with differences in synchronization of brain activity during rest and mental rehearsal. | de Bruin EA et al. | β | 2006 | β |
| Suppression of early evoked gamma band response in male alcoholics during a visual oddball task. | Padmanabhapillai A et al. | β | 2006 | β |
| Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. | Flatscher-Bader T et al. | β | 2005 | β |
| Chronic effects of social drinking in a card-sorting task: an event related potential study. | Bijl S et al. | β | 2005 | β |
| Demographic influences on baseline and derived scores from the trail making test in healthy older Australian adults. | Hester RL et al. | β | 2005 | β |
| Genetic influences in emotional dysfunction and alcoholism-related brain damage. | Oscar-Berman M et al. | β | 2005 | β |
| Relationship of the Wender Utah Rating Scale to objective measures of attention. | Mackin RS et al. | β | 2005 | β |
| Comparisons of Korsakoff and non-Korsakoff alcoholics on neuropsychological tests of prefrontal brain functioning. | Oscar-Berman M et al. | β | 2004 | β |
| Executive functioning early in abstinence from alcohol. | Zinn S et al. | β | 2004 | β |
| The role of brain oscillations as functional correlates of cognitive systems: a study of frontal inhibitory control in alcoholism. | Kamarajan C et al. | β | 2004 | β |
| Abnormal CNV in chronic heavy drinkers. | Chao LL et al. | β | 2003 | β |