Alternative strategies for uncovering genes contributing to alcoholism risk: unpredictable findings in a genetic wonderland.
- Authors
- Hill, S Y
- Year
- 1998
- Journal
- Alcohol (Fayetteville, N.Y.)
- PMID
- 9650636
- DOI
- 10.1016/s0741-8329(97)00177-8
In spite of technological advances in genetic mapping, the field of alcoholism genetics has had few findings that could be confirmed. Possible sources for the largely negative results and suggested ways for improving the search for genes contributing to alcoholism risk are discussed. These include the choice of phenotype to be studied, whether narrow or broad, whether only mild or severe forms are included, and whether or not comorbidity should be excluded. The ascertainment schema for selecting families utilized in our laboratory which results in an especially high recurrence risk will be discussed with respect to finding candidate genes. The complexity of the alcoholism phenotype will be discussed with respect to the existence of phenocopies, genetic heterogeneity, and the difficulties associated with defining the disorder in a way that covers all ages and both genders adequately. Finally, the equivocal results found for the D2 dopamine receptor are discussed with respect to current data analytic techniques, which emphasize affected sib-pairs, techniques that may be especially problematic for a disorder such as alcoholism that has marked tendencies for phenocopies to arise.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genetic research: who is at risk for alcoholism. | 2010 | 23579937 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Theorizing The Role of Gama Type Endorphins in Schizophrenia and Alcoholism: Promoting Genetic Testing and Attempts at Inducing "Dopamine Homeostasis". | Blum K et al. | — | 2025 | → |
| Hypothesizing dopaminergic genetic antecedents in schizophrenia and substance seeking behavior. | Blum K et al. | — | 2014 | → |
| Low dopamine function in attention deficit/hyperactivity disorder: should genotyping signify early diagnosis in children? | Gold MS et al. | — | 2014 | → |
| Correlation of the Taq1 dopamine D2 receptor gene and percent body fat in obese and screened control subjects: a preliminary report. | Chen AL et al. | — | 2012 | → |
| Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviors. | Blum K et al. | — | 2011 | → |
| Genetic research: who is at risk for alcoholism. | Foroud T et al. | — | 2010 | → |
| Are dopaminergic genes involved in a predisposition to pathological aggression? Hypothesizing the importance of "super normal controls" in psychiatricgenetic research of complex behavioral disorders. | Chen TJ et al. | — | 2005 | → |
| D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. | Noble EP | — | 2003 | → |
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