Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism.
paper
Cited
Public
Unavailable
- Authors
- Enoch, Mary-Anne; Xu, Ke; Ferro, Erica; Harris, Claudia R; Goldman, David
- Year
- 2003
- Journal
- Psychiatric genetics
- PMID
- 12605099
- DOI
- 10.1097/00041444-200303000-00006
OBJECTIVE: Women are more prone to anxiety than men. The catechol- -methyltransferase functional polymorphism, Val158Met, is likely to be implicated in anxiety vulnerability. We hypothesized that, particularly in women, the low-activity Met158 allele would be associated with higher anxiety scores and a biological trait, low-voltage alpha resting electroencephalogram (EEG), previously associated with alcoholism and anxiety disorders. METHODS: DNA was obtained from two independent groups of participants ascertained as community samples: 149 predominantly Caucasian individuals (92 women, 57 men), and 252 Plains American Indians (149 women, 103 men). Dimensional measures of anxiety (Tridimensional Personality Questionnaire harm avoidance subscales HA1 and HA2) were obtained and DSM-III-R lifetime psychiatric diagnoses were determined. EEGs were recorded and EEG phenotypes assigned. RESULT: In both populations, women showed significant associations between catechol- -methyltransferase genotype and elevated harm avoidance scores, and the Met158/Met158 genotype was most strongly associated: predominantly Caucasian participants: HA1, P=0.03, HA2, P =0.03; and Plains American Indians: HA2, P=0.01. This was also the case with low-voltage alpha resting EEG: predominantly Caucasian participants: P=0.01, odds ratio=5.0 (95% confidence interval, 1.3-18.7); Plains American Indians: P=0.03, odds ratio=3.7 (95% confidence interval, 1.1-12.7). CONCLUSIONS: The results of the present study suggest that an inherited difference in catecholamine metabolism is important in the pathogenesis of anxiety in women.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Association of Genetic Variants, Such as the ΞΌ-Opioid Receptor 1 (<i>OPRM1</i>) <i>rs1799971</i> and Catechol-O-Methyltransferase (<i>COMT</i>) <i>rs4680,</i> with Phenotypic Expression of Fibromyalgia. | Erenas Ondategui I et al. | β | 2025 | β |
| Early life stress induced sex-specific changes in behavior is paralleled by altered locus coeruleus physiology in BALB/cJ mice. | Brannan S et al. | β | 2024 | β |
| Neural indices of heritable impulsivity: Impact of the COMT Val158Met polymorphism on frontal beta power during early motor preparation. | Happer JP et al. | β | 2024 | β |
| Dexmedetomidine alleviates anxiety-like behaviors in female mice with musculoskeletal pain through SIRT1/p53 axis. | Zhou Q et al. | β | 2023 | β |
| Effects of DRD2/ANKK1 and COMT Val158Met polymorphisms on stabilization against and adaptation to unexpected events. | Trempler I et al. | β | 2022 | β |
| Gene expression associated with human brain activations in facial expression recognition. | Wang Z et al. | β | 2022 | β |
| Investigating interactive effects of worry and the catechol-o-methyltransferase gene (COMT) on working memory performance. | Louis CC et al. | β | 2021 | β |
| Alterations of Functional Connectivity During the Resting State and Their Associations With Visual Memory in College Students Who Binge Drink. | Kim BM et al. | β | 2020 | β |
| Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder. | Shao X et al. | β | 2020 | β |
| Catechol-O-methyltransferase gene expression in stress-induced and non-stress induced schizophrenia. | Aghamaleki-Sarvestani Z et al. | β | 2020 | β |
| Genetics of sex differences in neuroanatomy and function. | Sigurdardottir HL et al. | β | 2020 | β |
| Pharmacogenetics of anxiety disorders. | McGowan OO | β | 2020 | β |
| Age-specific associations among functional COMT Val<sup>158</sup>Met polymorphism, resting parasympathetic nervous control and generalized anxiety disorder. | Chang HA et al. | β | 2019 | β |
| Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated with Anxiety, Depression, and Widespread Pressure Pain Sensitivity in Women with Chronic, but Not Episodic, Migraine. | FernΓ‘ndez-de-Las-PeΓ±as C et al. | β | 2019 | β |
| Heterosis in COMT Val158Met Polymorphism Contributes to Sex-Differences in Children's Math Anxiety. | JΓΊlio-Costa A et al. | β | 2019 | β |
| The Association Between Affective Temperament Traits and Dopamine Genes in Obese Population. | Lesiewska N et al. | β | 2019 | β |
| Association between COMT SNP variation and timidity in Golden and Labrador Retrievers. | Luo D et al. | β | 2018 | β |
| COMT val158met polymorphism links to altered fear conditioning and extinction are modulated by PTSD and childhood trauma. | Deslauriers J et al. | β | 2018 | β |
| Haplotypic and Genotypic Association of Catechol-<i>O</i>-Methyltransferase rs4680 and rs4818 Polymorphisms and Treatment Resistance in Schizophrenia. | Sagud M et al. | β | 2018 | β |
| The association between COMT rs4680 and 5-HTTLPR genotypes and concussion history in South African rugby union players. | Mc Fie S et al. | β | 2018 | β |
| Toward the Language Oscillogenome. | Murphy E et al. | β | 2018 | β |
| Association between <i>COMT</i> Val158Met and <i>DAT1</i> polymorphisms and depressive symptoms in the obese population. | BieliΕski M et al. | β | 2017 | β |
| Genetics of generalized anxiety disorder and related traits. | Gottschalk MG et al. | β | 2017 | β |
| Identifying new susceptibility genes on dopaminergic and serotonergic pathways for the framing effect in decision-making. | Gao X et al. | β | 2017 | β |
| Interaction Between Val158Met Catechol-O-Methyltransferase Polymorphism and Social Cognitive Functioning in Schizophrenia: Pilot Study. | Tylec A et al. | β | 2017 | β |
| Paleo-oscillomics: inferring aspects of Neanderthal language abilities from gene regulation of neural oscillations | Murphy E et al. | β | 2017 | β |
| Candidate genes for alcohol dependence: A genetic association study from India. | Malhotra S et al. | β | 2016 | β |
| Childhood Trauma and COMT Genotype Interact to Increase Hippocampal Activation in Resilient Individuals. | van Rooij SJ et al. | β | 2016 | β |
| COMT Val158Met polymorphism influences the susceptibility to framing in decision-making: OFC-amygdala functional connectivity as a mediator. | Gao X et al. | β | 2016 | β |
| Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly Specific, Novel Mouse Model of Altered COMT Activity. | Barkus C et al. | β | 2016 | β |
| Meta-analysis of the COMT Val158Met polymorphism in major depressive disorder: the role of gender. | Klein M et al. | β | 2016 | β |
| Older age may offset genetic influence on affect: The COMT polymorphism and affective well-being across the life span. | Turan B et al. | β | 2016 | β |
| Sex differences in the locus coeruleus-norepinephrine system and its regulation by stress. | Bangasser DA et al. | β | 2016 | β |
| Voxelwise eigenvector centrality mapping of the human functional connectome reveals an influence of the catechol-O-methyltransferase val158met polymorphism on the default mode and somatomotor network. | Markett S et al. | β | 2016 | β |
| Advances in Electrophysiological Research. | Kamarajan C et al. | β | 2015 | β |
| COMT polymorphism modulates the resting-state EEG alpha oscillatory response to acute nicotine in male non-smokers. | Bowers H et al. | β | 2015 | β |
| Modulation of the COMT Val(158)Met polymorphism on resting-state EEG power. | SolΓs-Ortiz S et al. | β | 2015 | β |
| Multilevel impact of the dopamine system on the emotion-potentiated startle reflex. | Domschke K et al. | β | 2015 | β |
| Multivariate genetic determinants of EEG oscillations in schizophrenia and psychotic bipolar disorder from the BSNIP study. | Narayanan B et al. | β | 2015 | β |
| Network-Dependent Modulation of COMT and DRD2 Polymorphisms in Healthy Young Adults. | Zhao F et al. | β | 2015 | β |
| The COMT val(158)met polymorphism in ultra-endurance athletes. | van Breda K et al. | β | 2015 | β |
| Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts. | Veth CP et al. | β | 2014 | β |
| Association of the catechol-O-methyltransferase val158met polymorphism and anxiety-related traits: a meta-analysis. | Lee LO et al. | β | 2014 | β |
| Catechol-O-methyltransferase val158met genotype determines effect of reboxetine on emotional memory in healthy male volunteers. | Gibbs AA et al. | β | 2014 | β |
| Genetic modulation of the response bias towards facial displays of anger and happiness. | Gohier B et al. | β | 2014 | β |
| Genetic polymorphisms and traumatic brain injury: the contribution of individual differences to recovery. | Weaver SM et al. | β | 2014 | β |
| Heritability and molecular-genetic basis of resting EEG activity: a genome-wide association study. | Malone SM et al. | β | 2014 | β |
| Interaction effects of the COMT and DRD4 genes with anxiety-related traits on selective attention. | Alfimova M et al. | β | 2014 | β |
| Neonatal pain and COMT Val158Met genotype in relation to serotonin transporter (SLC6A4) promoter methylation in very preterm children at school age. | Chau CM et al. | β | 2014 | β |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | β | 2014 | β |
| Age-dependent effect of Alzheimer's risk variant of CLU on EEG alpha rhythm in non-demented adults. | Ponomareva N et al. | β | 2013 | β |
| Catechol-O-methyltransferase (COMT) genotype biases neural correlates of empathy and perceived personal distress in schizophrenia. | Poletti S et al. | β | 2013 | β |
| Catechol-O-methyltransferase gene val158met polymorphism and depressive symptoms during early childhood. | Sheikh HI et al. | β | 2013 | β |
| Catechol-O-methyltransferase Val158Met polymorphism modulates gray matter volume and functional connectivity of the default mode network. | Tian T et al. | β | 2013 | β |
| Differential Genetic and Epigenetic Regulation of catechol-O-methyltransferase is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder. | Norrholm SD et al. | β | 2013 | β |
| Dopaminergic modulation of memory and affective processing in Parkinson depression. | Blonder LX et al. | β | 2013 | β |
| EEG alpha power as an intermediate measure between brain-derived neurotrophic factor Val66Met and depression severity in patients with major depressive disorder. | Zoon HF et al. | β | 2013 | β |
| Effect of COMT Val158Met polymorphism on personality traits and educational attainment in a longitudinal population representative study. | Lehto K et al. | β | 2013 | β |
| Evidence for a genetic component for substance dependence in Native Americans. | Ehlers CL et al. | β | 2013 | β |
| Interaction between catechol-O-methyltransferase (COMT) Val158Met genotype and genetic vulnerability to schizophrenia during explicit processing of aversive facial stimuli. | Lo Bianco L et al. | β | 2013 | β |
| Observed positive parenting behaviors and youth genotype: evidence for gene-environment correlations and moderation by parent personality traits. | Oppenheimer CW et al. | β | 2013 | β |
| Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene. | MartΓnez-Jauand M et al. | β | 2013 | β |
| Sexually dimorphic effects of catechol-O-methyltransferase (COMT) inhibition on dopamine metabolism in multiple brain regions. | Laatikainen LM et al. | β | 2013 | β |
| The effects of the catechol-O-methyltransferase val158met polymorphism on white matter connectivity in patients with panic disorder. | Kim B et al. | β | 2013 | β |
| The influence of the Val158Met catechol-O-methyltransferase polymorphism on the personality traits of bipolar patients. | DΓ‘vila W et al. | β | 2013 | β |
| The interaction of early life experiences with COMT val158met affects anxiety sensitivity. | Baumann C et al. | β | 2013 | β |
| Affect-modulated startle: interactive influence of catechol-O-methyltransferase Val158Met genotype and childhood trauma. | Klauke B et al. | β | 2012 | β |
| Anxiety and fear-avoidance in musculoskeletal pain. | Lucchetti G et al. | β | 2012 | β |
| Catechol-O-methyltransferase gene variation: impact on amygdala response to aversive stimuli. | Domschke K et al. | β | 2012 | β |
| Children under stress - COMT genotype and stressful life events predict cortisol increase in an acute social stress paradigm. | Armbruster D et al. | β | 2012 | β |
| Genetic associations with performance on a behavioral measure of distress intolerance. | Amstadter AB et al. | β | 2012 | β |
| Genetic polymorphisms influence recovery from traumatic brain injury. | Weaver SM et al. | β | 2012 | β |
| Pain, affective symptoms, and cognitive deficits in patients with cerebral dopamine dysfunction. | Jarcho JM et al. | β | 2012 | β |
| Serotonin-2A receptor and catechol-O-methyltransferase polymorphisms in panic disorder. | Karacetin G et al. | β | 2012 | β |
| The genetic basis of addictive disorders. | Ducci F et al. | β | 2012 | β |
| The relationship between risk-taking propensity and the COMT Val(158)Met polymorphism among early adolescents as a function of sex. | Amstadter AB et al. | β | 2012 | β |
| COMT Val158Met polymorphism, verbalizing of emotion and activation of affective brain systems. | Swart M et al. | β | 2011 | β |
| Contributions of dopamine-related genes and environmental factors to highly sensitive personality: a multi-step neuronal system-level approach. | Chen C et al. | β | 2011 | β |
| Genetics of emotion. | Bevilacqua L et al. | β | 2011 | β |
| Importance of the COMT gene for sex differences in brain function and predisposition to psychiatric disorders. | Tunbridge EM et al. | β | 2011 | β |
| Role of functional dopaminergic gene polymorphisms in the etiology of idiopathic intellectual disability. | Bhowmik AD et al. | β | 2011 | β |
| Sex modulates the associations between the COMT gene and personality traits. | Chen C et al. | β | 2011 | β |
| The association of schizophrenia risk D-amino acid oxidase polymorphisms with sensorimotor gating, working memory and personality in healthy males. | Roussos P et al. | β | 2011 | β |
| Variation in genes involved in dopamine clearance influence the startle response in older adults. | Armbruster D et al. | β | 2011 | β |
| Aversive stimuli lead to differential amygdala activation and connectivity patterns depending on catechol-O-methyltransferase Val158Met genotype. | Rasch B et al. | β | 2010 | β |
| Catechol-O-methyltransferase Val 158 Met polymorphism and antisaccade eye movements in schizophrenia. | Haraldsson HM et al. | β | 2010 | β |
| Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice. | Segall SK et al. | β | 2010 | β |
| COMT genotype affects prefrontal white matter pathways in children and adolescents. | Thomason ME et al. | β | 2010 | β |
| COMT Val(108/158)Met polymorphism effects on emotional brain function and negativity bias. | Williams LM et al. | β | 2010 | β |
| EEG alpha phenotypes: linkage analyses and relation to alcohol dependence in an American Indian community study. | Ehlers CL et al. | β | 2010 | β |
| EEG spectral phenotypes: heritability and association with marijuana and alcohol dependence in an American Indian community study. | Ehlers CL et al. | β | 2010 | β |
| Executive functions and selective attention are favored in middle-aged healthy women carriers of the Val/Val genotype of the catechol-o-methyltransferase gene: a behavioral genetic study. | SolΓs-Ortiz S et al. | β | 2010 | β |
| Genetic variability in estrogen disposition: Potential clinical implications for neuropsychiatric disorders. | Grover S et al. | β | 2010 | β |
| Human dopamine receptor D2/D3 availability predicts amygdala reactivity to unpleasant stimuli. | Kobiella A et al. | β | 2010 | β |
| Neural markers of genetic vulnerability to drug addiction. | MΓΌller DJ et al. | β | 2010 | β |
| Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis. | Mier D et al. | β | 2010 | β |
| The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder. | Lonsdorf TB et al. | β | 2010 | β |
| The impact of placebo, psychopathology, and expectations on the response to acupuncture needling in patients with chronic low back pain. | Wasan AD et al. | β | 2010 | β |
| The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism. | Kolassa IT et al. | β | 2010 | β |
| Catechol O-methyltransferase (COMT) VAL158MET functional polymorphism, dental mercury exposure, and self-reported symptoms and mood. | Heyer NJ et al. | β | 2009 | β |
| COMT genotype and resting brain perfusion in children. | Thomason ME et al. | β | 2009 | β |
| COMT Val158Met and cognition: main effects and interaction with educational attainment. | Enoch MA et al. | β | 2009 | β |
| Emotional symptoms in children: The effect of maternal depression, life events, and COMT genotype. | Evans J et al. | β | 2009 | β |
| Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans. | Blasi G et al. | β | 2009 | β |
| Genetic and non-genetic influences on the development of co-occurring alcohol problem use and internalizing symptomatology in adolescence: a review. | Saraceno L et al. | β | 2009 | β |
| Genetics of emotion regulation. | Canli T et al. | β | 2009 | β |
| Haplotype associations with quantitative traits in the presence of complex multilocus and heterogeneous effects. | Shibata K et al. | β | 2009 | β |
| Identification of a novel haplotype of the human catechol-O-methyltransferase gene. | Bai HW et al. | β | 2009 | β |
| The effects of gender and COMT Val158Met polymorphism on fearful facial affect recognition: a fMRI study. | Kempton MJ et al. | β | 2009 | β |
| The functional Val158Met polymorphism of COMT predicts interindividual differences in brain alpha oscillations in young men. | Bodenmann S et al. | β | 2009 | β |
| Tolcapone effects on gating, working memory, and mood interact with the synonymous catechol-O-methyltransferase rs4818c/g polymorphism. | Roussos P et al. | β | 2009 | β |
| Variation in dopamine genes influences responsivity of the human reward system. | Dreher JC et al. | β | 2009 | β |
| Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of patients with schizophrenia. | Docherty AR et al. | β | 2008 | β |
| Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders. | Harrison PJ et al. | β | 2008 | β |
| Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes. | Hettema JM et al. | β | 2008 | β |
| Catechol-O-methyltransferase val158met genotype influences neural processing of reward anticipation. | Schmack K et al. | β | 2008 | β |
| Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: the Nord-TrΓΈndelag Health Study (HUNT). | Baekken PM et al. | β | 2008 | β |
| Effect of functional catechol-O-methyltransferase Val158Met polymorphism on physical aggression. | Kulikova MA et al. | β | 2008 | β |
| Evidence that the COMT(Val158Met) polymorphism moderates sensitivity to stress in psychosis: an experience-sampling study. | van Winkel R et al. | β | 2008 | β |
| Genes and neuroimaging: advances in psychiatric research. | Gallinat J et al. | β | 2008 | β |
| Genetic approaches to addiction: genes and alcohol. | Ducci F et al. | β | 2008 | β |
| Genetics and neuroimaging of attention and hypnotizability may elucidate placebo. | Raz A | β | 2008 | β |
| Genetic variation in the schizophrenia-risk gene neuregulin1 correlates with personality traits in healthy individuals. | Krug A et al. | β | 2008 | β |
| How will information about the genetic risk of mental disorders impact on stigma? | Spriggs M et al. | β | 2008 | β |
| Influence of the catechol-O-methyltransferase val158met genotype on amygdala and prefrontal cortex emotional processing in panic disorder. | Domschke K et al. | β | 2008 | β |
| Molecular genetics of anxiety in mice and men. | Hovatta I et al. | β | 2008 | β |
| Neurophysiological and genetic distinctions between pure and comorbid anxiety disorders. | Enoch MA et al. | β | 2008 | β |
| Planning, decision-making and the COMT rs4818 polymorphism in healthy males. | Roussos P et al. | β | 2008 | β |
| Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction. | van Winkel R et al. | β | 2008 | β |
| Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes. | Rangaswamy M et al. | β | 2008 | β |
| Using genetic data in cognitive neuroscience: from growing pains to genuine insights. | Green AE et al. | β | 2008 | β |
| What is the genetic relationship between anxiety and depression? | Hettema JM | β | 2008 | β |
| An association study of DRD2 and COMT polymorphisms with novelty seeking and harm avoidance scores, in two independent samples of depressed patients. | Light KJ et al. | β | 2007 | β |
| Association of EEG alpha variants and alpha power with alcohol dependence in Mexican American young adults. | Ehlers CL et al. | β | 2007 | β |
| Catechol-o-methyltransferase polymorphism and susceptibility to major depressive disorder modulates psychological stress response. | Jabbi M et al. | β | 2007 | β |
| Catechol-O-methyltransferase polymorphism (COMT) in suicide attempters: a possible gender effect on anger traits. | Baud P et al. | β | 2007 | β |
| COMT Val158Met moderation of stress-induced psychosis. | Stefanis NC et al. | β | 2007 | β |
| Differential effect of catechol-O-methyltransferase Val158Met genotype on emotional recognition abilities in healthy men and women. | Weiss EM et al. | β | 2007 | β |
| Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder. | Berk M et al. | β | 2007 | β |
| Gender-dependent association of the functional catechol-O-methyltransferase Val158Met genotype with sensation seeking personality trait. | Lang UE et al. | β | 2007 | β |
| Gene-gene effects on central processing of aversive stimuli. | Smolka MN et al. | β | 2007 | β |
| Genetic variation in catechol-O-methyltransferase (COMT) and obesity in the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial. | Wang SS et al. | β | 2007 | β |
| Heritability of bipolar EEG spectra in a large sib-pair population. | Tang Y et al. | β | 2007 | β |
| Hormonal and genetic influences on processing reward and social information. | CaldΓΊ X et al. | β | 2007 | β |
| Influence of psychological factors on risk of temporomandibular disorders. | Slade GD et al. | β | 2007 | β |
| Interactions among higher trait anxiety, sympathetic activity, and endothelial function in the elderly. | Narita K et al. | β | 2007 | β |
| Irritable assault and variation in the COMT gene. | Flory JD et al. | β | 2007 | β |
| Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gender specificity. | Domschke K et al. | β | 2007 | β |
| Relationship of catechol-O-methyltransferase to schizophrenia and its correlates: evidence for associations and complex interactions. | Lewandowski KE | β | 2007 | β |
| A gender-moderated effect of a functional COMT polymorphism on prefrontal brain morphology and function in velo-cardio-facial syndrome (22q11.2 deletion syndrome). | Kates WR et al. | β | 2006 | β |
| An association study of catechol-O-methyltransferase and monoamine oxidase A polymorphisms and personality traits in Koreans. | Kim SJ et al. | β | 2006 | β |
| Associations between the COMT Val/Met polymorphism, early life stress, and personality among healthy adults. | Hoth KF et al. | β | 2006 | β |
| Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. | Tunbridge EM et al. | β | 2006 | β |
| Combined analysis of association between personality traits and three functional polymorphisms in the tyrosine hydroxylase, monoamine oxidase A, and catechol-O-methyltransferase genes. | Tochigi M et al. | β | 2006 | β |
| COMT genotype influences prefrontal response to emotional distraction. | Bishop SJ et al. | β | 2006 | β |
| COMT genotype predicts BOLD signal and noise characteristics in prefrontal circuits. | Winterer G et al. | β | 2006 | β |
| Genetic and environmental influences on the development of alcoholism: resilience vs. risk. | Enoch MA | β | 2006 | β |
| Genetics of human brain oscillations. | Begleiter H et al. | β | 2006 | β |
| Imaging genomics applied to anxiety, stress response, and resiliency. | Xu K et al. | β | 2006 | β |
| Pronociceptive and antinociceptive effects of estradiol through endogenous opioid neurotransmission in women. | Smith YR et al. | β | 2006 | β |
| Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American Indians. | Enoch MA et al. | β | 2006 | β |
| Shared susceptibility region on chromosome 15 between autism and catatonia. | Chagnon YC | β | 2006 | β |
| Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations. | Beuten J et al. | β | 2006 | β |
| The effects of catechol O-methyltransferase genotype on brain activation elicited by affective stimuli and cognitive tasks. | Heinz A et al. | β | 2006 | β |
| Using ancestry-informative markers to define populations and detect population stratification. | Enoch MA et al. | β | 2006 | β |
| Association between the COMT Val158Met polymorphism and propensity to anxiety in an Australian population-based longitudinal study of adolescent health. | Olsson CA et al. | β | 2005 | β |
| Association of the functional catechol-O-methyltransferase VAL158MET polymorphism with the personality trait of extraversion. | Reuter M et al. | β | 2005 | β |
| Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. | Smolka MN et al. | β | 2005 | β |
| COMT polymorphisms and anxiety-related personality traits. | Stein MB et al. | β | 2005 | β |
| Development of medications for alcohol use disorders: recent advances and ongoing challenges. | Litten RZ et al. | β | 2005 | β |
| Functional and structural comparisons of cysteine residues in the Val108 wild type and Met108 variant of human soluble catechol O-methyltransferase. | Li Y et al. | β | 2005 | β |
| Interface of physical and emotional stress regulation through the endogenous opioid system and mu-opioid receptors. | Ribeiro SC et al. | β | 2005 | β |
| The association between negative affect and opioid analgesia in patients with discogenic low back pain. | Wasan AD et al. | β | 2005 | β |
| The functional COMT polymorphism, Val 158 Met, is associated with logical memory and the personality trait intellect/imagination in a cohort of healthy 79 year olds. | Harris SE et al. | β | 2005 | β |
| The genetics of addictions: uncovering the genes. | Goldman D et al. | β | 2005 | β |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | β | 2005 | β |
| Alcoholism: genes and mechanisms. | Oroszi G et al. | β | 2004 | β |
| Association between catechol-O-methyltransferase and phobic anxiety. | McGrath M et al. | β | 2004 | β |
| Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5' nuclease assay. | Zhu G et al. | β | 2004 | β |
| Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. | Chen J et al. | β | 2004 | β |
| Genetics of anxiety disorders. | Arnold PD et al. | β | 2004 | β |
| Genotyping of three single nucleotide polymorphisms following whole genome preamplification of DNA collected from buccal cells. | Haberstick BC et al. | β | 2004 | β |
| Oxidative inhibition of human soluble catechol-O-methyltransferase. | Cotton NJ et al. | β | 2004 | β |
| Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: a call to action. | O'Brien CP et al. | β | 2004 | β |
| Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. | Barr CS et al. | β | 2004 | β |
| The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes. | Bilder RM et al. | β | 2004 | β |
| Understanding behaviour in a complex environment. The sixth annual meeting of the International Behavioural and Neural Genetics Society, New Orleans, LA, USA, November 5-7, 2003. | Bouwknecht JA et al. | β | 2004 | β |
| Alcoholism and human electrophysiology. | Porjesz B et al. | β | 2003 | β |
| Pharmacogenomics of alcohol response and addiction. | Enoch MA | β | 2003 | β |