Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4.
paper
Cited
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- Authors
- Cutting, G R; Curristin, S; Zoghbi, H; O'Hara, B; Seldin, M F; Uhl, G R
- Year
- 1992
- Journal
- Genomics
- PMID
- 1315307
- DOI
- 10.1016/0888-7543(92)90312-g
Screening of a genomic DNA library with a portion of the cDNA encoding the gamma-aminobutyric acid (GABA) receptor subunit rho1 identified two distinct clones. DNA sequencing revealed that one clone contained a single exon from the rho1 gene (GABBR1) while the second clone encompassed an exon with 96% identity to the rho1 gene. Screening of a human retina cDNA library with oligonucleotides specific for the exon in the second clone identified a 3-kb cDNA with an open reading frame of 1395 bp. The predicted amino acid sequence of this cDNA demonstrates 30 to 38% similarity to alpha, beta, gamma, and delta GABA receptor subunits and 74% similarity to the GABA rho1 subunit suggesting that the newly isolated cDNA encodes a new member of the rho subunit family, tentatively named GABA rho2. Polymerase chain reaction (PCR) amplification of rho1 and rho2 gene sequences from DNA of three somatic cell hybrid panels maps both genes to human chromosome 6, bands q14 to q21. Tight linkage was also demonstrated between restriction fragment length variants (RFLVs) from each rho gene and the Tsha locus on mouse chromosome 4, which is homologous to the CGA locus on human chromosome 6q12-q21. These two lines of evidence confirm that GABRR1 and newly identified GABRR2 map to the same region on human chromosome 6. This close physical association and high degree of sequence similarity raises the possibility that one rho gene arose from the other by duplication.
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| Title | Year | PMID |
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| GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence. | 2010 | 19536785 |
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
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| Characterization of zebrafish GABA<sub>A</sub> receptor subunits. | Sadamitsu K et al. | β | 2021 | β |
| GABA<sub>A</sub> receptors in GtoPdb v.2021.3. | Belelli D et al. | β | 2021 | β |
| Inhibition of GABA<sub>A</sub>-Ο receptors induces retina regeneration in zebrafish. | Kent MR et al. | β | 2021 | β |
| Copy Number Variation Pattern for Discriminating MACROD2 States of Colorectal Cancer Subtypes. | Zhang S et al. | β | 2019 | β |
| Huntington's disease leads to decrease of GABA-A tonic subunits in the D2 neostriatal pathway and their relocalization into the synaptic cleft. | Rosas-Arellano A et al. | β | 2018 | β |
| GABA-Ο receptors: distinctive functions and molecular pharmacology. | Naffaa MM et al. | β | 2017 | β |
| Mutation of the inhibitory ethanol site in GABA<sub>A</sub> Ο1 receptors promotes tolerance to ethanol-induced motor incoordination. | Blednov YA et al. | β | 2017 | β |
| Identification of an Inhibitory Alcohol Binding Site in GABAA Ο1 Receptors. | Borghese CM et al. | β | 2016 | β |
| Investigating the Role of Loop C Hydrophilic Residue 'T244' in the Binding Site of Ο1 GABAC Receptors via Site Mutation and Partial Agonism. | Naffaa MM et al. | β | 2016 | β |
| The binding mode of picrotoxinin in GABA<sub>A-Ο</sub> receptors: Insight into the subunit's selectivity in the transmembrane domain. | Naffaa MM et al. | β | 2016 | β |
| Downregulation of GABAA receptor protein subunits Ξ±6, Ξ²2, Ξ΄, Ξ΅, Ξ³2, ΞΈ, and Ο2 in superior frontal cortex of subjects with autism. | Fatemi SH et al. | β | 2014 | β |
| An historical perspective on GABAergic drugs. | Froestl W | β | 2011 | β |
| Enhancement of GABAergic activity: neuropharmacological effects of benzodiazepines and therapeutic use in anesthesiology. | Saari TI et al. | β | 2011 | β |
| A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. | Wang KS et al. | β | 2010 | β |
| An Update on GABAΟ Receptors. | MartΓnez-Delgado G et al. | β | 2010 | β |
| GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence. | Xuei X et al. | β | 2010 | β |
| Neurochemicals for the investigation of GABA(C) receptors. | Johnston GA et al. | β | 2010 | β |
| GABA(C) receptors are expressed in GABAergic and non-GABAergic neurons of the rat superior colliculus and visual cortex. | Grabert J et al. | β | 2009 | β |
| Autoradiographic analysis of GABAA receptors in mu-opioid receptor knockout mice. | Tien LT et al. | β | 2007 | β |
| Early evolution of ionotropic GABA receptors and selective regimes acting on the mammalian-specific theta and epsilon subunits. | Martyniuk CJ et al. | β | 2007 | β |
| Study on olfactory function in GABAC receptor/channel rho1 subunit knockout mice. | Chen Y et al. | β | 2007 | β |
| Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors. | Crittenden DL et al. | β | 2006 | β |
| Cloning and functional expression of the bovine GABA(C) rho2 subunit. Molecular evidence of a widespread distribution in the CNS. | LΓ³pez-ChΓ‘vez A et al. | β | 2005 | β |
| Consequences of the evolution of the GABA(A) receptor gene family. | Darlison MG et al. | β | 2005 | β |
| Functional characterization of rat rho2 subunits expressed in HEK 293 cells. | Alakuijala A et al. | β | 2005 | β |
| gamma-Aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathway. | Fava G et al. | β | 2005 | β |
| Interactions between rho and gamma2 subunits of the GABA receptor. | Pan Y et al. | β | 2005 | β |
| Pharmacology of GABAC receptors: responses to agonists and antagonists distinguish A- and B-subtypes of homomeric rho receptors expressed in Xenopus oocytes. | Pan Y et al. | β | 2005 | β |
| Analysis of the set of GABA(A) receptor genes in the human genome. | Simon J et al. | β | 2004 | β |
| Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability. | Carland JE et al. | β | 2004 | β |
| Ionotropic GABA receptors with mixed pharmacological properties of GABAA and GABAC receptors. | Hartmann K et al. | β | 2004 | β |
| Mutations of the 2' proline in the M2 domain of the human GABAC rho1 subunit alter agonist responses. | Carland JE et al. | β | 2004 | β |
| Function of gamma-aminobutyric acid receptor/channel rho 1 subunits in spinal cord. | Zheng W et al. | β | 2003 | β |
| Elimination of the rho1 subunit abolishes GABA(C) receptor expression and alters visual processing in the mouse retina. | McCall MA et al. | β | 2002 | β |
| GABA and GABA receptors in the central nervous system and other organs. | Watanabe M et al. | β | 2002 | β |
| trans-4-Amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA(C) receptors. | Vien J et al. | β | 2002 | β |
| Developmentally regulated expression of GABA receptor rho1 and rho2 subunits, L7 and cone-rod homeobox (CRX) genes in mouse retina. | Wu Y et al. | β | 2001 | β |
| Expression of gamma-aminobutyric acid rho 1 and rho 1 Delta 450 as gene fusions with the green fluorescent protein. | Martinez-Torres A et al. | β | 2001 | β |
| GABA(C) receptors: a molecular view. | Enz R | β | 2001 | β |
| Structure and function of GABA(C) receptors: a comparison of native versus recombinant receptors. | Zhang D et al. | β | 2001 | β |
| The effects of cyclopentane and cyclopentene analogues of GABA at recombinant GABA(C) receptors. | Chebib M et al. | β | 2001 | β |
| Activation of protein kinase C induces internalization of the GABA(C) receptors expressed in Xenopus oocytes. | Kusama T et al. | β | 2000 | β |
| A minimal promoter for the GABA(A) receptor alpha6-subunit gene controls tissue specificity. | McLean PJ et al. | β | 2000 | β |
| (+)- and (-)-cis-2-aminomethylcyclopropanecarboxylic acids show opposite pharmacology at recombinant rho(1) and rho(2) GABA(C) receptors. | Duke RK et al. | β | 2000 | β |
| A new locus for dominant drusen and macular degeneration maps to chromosome 6q14. | Kniazeva M et al. | β | 2000 | β |
| A novel locus for Leber congenital amaurosis maps to chromosome 6q. | Dharmaraj S et al. | β | 2000 | β |
| cDNA cloning and expression of a gamma-aminobutyric acid A receptor epsilon-subunit in rat brain. | Moragues N et al. | β | 2000 | β |
| Different sensitivities of human and rat rho(1) GABA receptors to extracellular pH. | Rivera C et al. | β | 2000 | β |
| Evidence for coassembly of mutant GABAC rho1 with GABAA gamma2S, glycine alpha1 and glycine alpha2 receptor subunits in vitro. | Pan ZH et al. | β | 2000 | β |
| GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology. | Chebib M et al. | β | 2000 | β |
| GABArho 1/GABAAalpha 1 receptor chimeras to study receptor desensitization. | MartΓnez-Torres A et al. | β | 2000 | β |
| Mutation analysis of GABRR1 and GABRR2 in autosomal recessive retinitis pigmentosa. | Marcos I et al. | β | 2000 | β |
| Acute effects of ethanol on GABAA and glycine receptor function. | Mihic SJ | β | 1999 | β |
| Aminomethyl-2,6-difluorophenols as a novel class of increased lipophilicity GABA(C) receptor antagonists. | Chebib M et al. | β | 1999 | β |
| An update on GABAA receptors. | Mehta AK et al. | β | 1999 | β |
| A sequence-ready BAC contig of the GABAA receptor gene cluster Gabrg1-Gabra2-Gabrb1 on mouse chromosome 5. | Lengeling A et al. | β | 1999 | β |
| A single amino acid in the second transmembrane domain of GABA rho subunits is a determinant of the response kinetics of GABAC receptors. | Qian H et al. | β | 1999 | β |
| Bicuculline-resistant, Cl- dependent GABA response in the rat spinal dorsal horn. | Park JS et al. | β | 1999 | β |
| GABA(A) and GABA(C) receptors have contrasting effects on excitability in superior colliculus. | Pasternack M et al. | β | 1999 | β |
| GABAC receptor rho subunits are heterogeneously expressed in the human CNS and form homo- and heterooligomers with distinct physical properties. | Enz R et al. | β | 1999 | β |
| General anaesthetic actions on ligand-gated ion channels. | Krasowski MD et al. | β | 1999 | β |
| Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3. | Bailey ME et al. | β | 1999 | β |
| Identification of 70 amino acids important for GABA(C) receptor rho1 subunit assembly. | Enz R et al. | β | 1999 | β |
| Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials. | Williams JT et al. | β | 1999 | β |
| Localisation of the GABA(C) receptors at the axon terminal of the rod bipolar cells of the mouse retina. | Vaquero CF et al. | β | 1999 | β |
| Response kinetics and pharmacological properties of heteromeric receptors formed by coassembly of GABA rho- and gamma 2-subunits. | Qian H et al. | β | 1999 | β |
| The 'ABC' of GABA receptors: a brief review. | Chebib M et al. | β | 1999 | β |
| A major locus for autosomal recessive retinitis pigmentosa on 6q, determined by homozygosity mapping of chromosomal regions that contain gamma-aminobutyric acid-receptor clusters. | Ruiz A et al. | β | 1998 | β |
| Amino acid neurotransmitters in the retina: a functional overview. | Wu SM et al. | β | 1998 | β |
| Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation. | Kusama T et al. | β | 1998 | β |
| Different contributions of GABAA and GABAC receptors to rod and cone bipolar cells in a rat retinal slice preparation. | Euler T et al. | β | 1998 | β |
| Distribution of GABA receptor rho subunit transcripts in the rat brain. | Wegelius K et al. | β | 1998 | β |
| Downregulation and subcellular redistribution of the gamma-aminobutyric acidA receptor induced by tunicamycin in cultured brain neurons. | Lin TY et al. | β | 1998 | β |
| GABAA and GABAC receptors on mammalian rod bipolar cells. | Fletcher EL et al. | β | 1998 | β |
| GABA(C) receptor antagonists differentiate between human rho1 and rho2 receptors expressed in Xenopus oocytes. | Chebib M et al. | β | 1998 | β |
| GABA-gated Cl- channels in the rat retina. | Feigenspan A et al. | β | 1998 | β |
| Glycine and GABA receptors in the mammalian retina. | WΓ€ssle H et al. | β | 1998 | β |
| Molecular composition of GABAC receptors. | Enz R et al. | β | 1998 | β |
| The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes. | Hevers W et al. | β | 1998 | β |
| A comparison of GABAC and rho subunit receptors from the white perch retina. | Qian H et al. | β | 1997 | β |
| Analogues of gamma-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. | Chebib M et al. | β | 1997 | β |
| GABAC receptors on ferret retinal bipolar cells: a diversity of subtypes in mammals? | Lukasiewicz PD et al. | β | 1997 | β |
| Immunocytochemical localization of the GABA(C) receptor rho subunits in the cat, goldfish, and chicken retina. | Koulen P et al. | β | 1997 | β |
| In situ hybridization and reverse transcription--polymerase chain reaction studies on the expression of the GABA(C) receptor rho1- and rho2-subunit genes in avian and rat brain. | Albrecht BE et al. | β | 1997 | β |
| Ionotropic GABA receptor from lobster olfactory projection neurons. | Zhainazarov AB et al. | β | 1997 | β |
| Structure and organization of GABRB3 and GABRA5. | Glatt K et al. | β | 1997 | β |
| The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction. | Hackam AS et al. | β | 1997 | β |
| Unsaturated phosphinic analogues of gamma-aminobutyric acid as GABA(C) receptor antagonists. | Chebib M et al. | β | 1997 | β |
| A functional comparison of the antagonists bicuculline and picrotoxin at recombinant GABAA receptors. | Krishek BJ et al. | β | 1996 | β |
| A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. | Garrett-Sinha LA et al. | β | 1996 | β |
| Cloning of a putative gamma-aminobutyric acid (GABA) receptor subunit rho 3 cDNA. | Ogurusu T et al. | β | 1996 | β |
| Correlation between a bicuculline-resistant response to GABA and GABAA receptor rho 1 subunit expression in single rat retinal bipolar cells. | Yeh HH et al. | β | 1996 | β |
| Effects of ethanol on ion channels. | Crews FT et al. | β | 1996 | β |
| Functional expression of GABA rho 3 receptors in Xenopus oocytes. | Shingai R et al. | β | 1996 | β |
| GABAC receptors in the vertebrate retina. | Lukasiewicz PD | β | 1996 | β |
| Genotype-to-phenotype analysis: search for clinical characteristics of a missense change in the GABAA-beta 1 receptor gene. | Sobell JL et al. | β | 1996 | β |
| Glutamate responses of bipolar cells in a slice preparation of the rat retina. | Euler T et al. | β | 1996 | β |
| Immunocytochemical localization of the GABAc receptor rho subunits in the mammalian retina. | Enz R et al. | β | 1996 | β |
| Molecular genetic analysis of the role of GABAergic systems in the behavioral and cellular actions of alcohol. | Buck KJ | β | 1996 | β |
| Structural and pharmacological aspects of the GABAA receptor: involvement in behavioral pathogenesis. | ClΓ©ment Y | β | 1996 | β |
| Synaptic organization of an organotypic slice culture of the mammalian retina. | SassoΓ¨-Pognetto M et al. | β | 1996 | β |
| The gene encoding the central cannabinoid receptor is located in proximal mouse Chromosome 4. | Stubbs L et al. | β | 1996 | β |
| A single amino acid in gamma-aminobutyric acid rho 1 receptors affects competitive and noncompetitive components of picrotoxin inhibition. | Wang TL et al. | β | 1995 | β |
| Biological function of GABAA/benzodiazepine receptor heterogeneity. | LΓΌddens H et al. | β | 1995 | β |
| Characterization of a benzodiazepine receptor site with exceptionally high affinity for Ro 15-4513 in the rat CNS. | Mehta AK et al. | β | 1995 | β |
| Chromosomal localization of opioid peptide and receptor genes in the mouse. | Giros B et al. | β | 1995 | β |
| Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block. | Zhang D et al. | β | 1995 | β |
| Deciphering the native GABAA receptor: is there hope? | Yeh HH et al. | β | 1995 | β |
| Expression of GABA receptor rho 1 and rho 2 subunits in the retina and brain of the rat. | Enz R et al. | β | 1995 | β |
| Expression of recombinant homo-oligomeric 5-hydroxytryptamine3 receptors provides new insights into their maturation and structure. | Green T et al. | β | 1995 | β |
| From ion currents to genomic analysis: recent advances in GABAA receptor research. | Rabow LE et al. | β | 1995 | β |
| Functional role of GABA in cat retina: II. Effects of GABAA antagonists. | Frumkes TE et al. | β | 1995 | β |
| GABAA/benzodiazepine receptor heterogeneity: neurophysiological implications. | LΓΌddens H et al. | β | 1995 | β |
| GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions. | O'Hara BF et al. | β | 1995 | β |
| GABAC receptors. | Bormann J et al. | β | 1995 | β |
| Interaction of abecarnil, bretazenil, and RO 19-8022 with diazepam-sensitive and -insensitive benzodiazepine sites in the rat cerebellum and cerebral cortex. | Mehta AK et al. | β | 1995 | β |
| Localization of the rho 1- and rho 2-subunit messenger RNAs in chick retina by in situ hybridization predicts the existence of gamma-aminobutyric acid type C receptor subtypes. | Albrecht BE et al. | β | 1995 | β |
| Mapping of the alpha 4 subunit gene (GABRA4) to human chromosome 4 defines an alpha 2-alpha 4-beta 1-gamma 1 gene cluster: further evidence that modern GABAA receptor gene clusters are derived from an ancestral cluster. | McLean PJ et al. | β | 1995 | β |
| Molecular cloning and chromosomal localization of a pseudogene related to the human acyl-CoA binding protein/diazepam binding inhibitor. | Gersuk VH et al. | β | 1995 | β |
| Regulation of GABAA receptor function and gene expression in the central nervous system. | Morrow AL | β | 1995 | β |
| Structure and pharmacology of vertebrate GABAA receptor subtypes. | Whiting PJ et al. | β | 1995 | β |
| The gamma-aminobutyric acid receptor gamma 3 subunit gene (GABRG3) is tightly linked to the alpha 5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation. | Greger V et al. | β | 1995 | β |
| A single amino acid of the human gamma-aminobutyric acid type A receptor gamma 2 subunit determines benzodiazepine efficacy. | Mihic SJ et al. | β | 1994 | β |
| BSF1, a novel brain-specific DNA-binding protein recognizing a tandemly repeated purine DNA element in the GABAA receptor delta subunit gene. | Motejlek K et al. | β | 1994 | β |
| Differential expression of GABAA receptor subunit mRNAs in ethanol-naive withdrawal seizure resistant (WSR) vs. withdrawal seizure prone (WSP) mouse brain. | Keir WJ et al. | β | 1994 | β |
| Differential pharmacology of GABAA and GABAC receptors on rat retinal bipolar cells. | Feigenspan A et al. | β | 1994 | β |
| Expression profiling of GABAA receptor beta-subunits in the rat retina. | Grigorenko EV et al. | β | 1994 | β |
| Facilitation of GABAergic signaling in the retina by receptors stimulating adenylate cyclase. | Feigenspan A et al. | β | 1994 | β |
| GABAA receptor alpha 1 subunit, an early marker for area specification in developing rat cerebral cortex. | Paysan J et al. | β | 1994 | β |
| Immunocytochemical localization of the beta 2 subunit of the gamma-aminobutyric acidA receptor in the rat brain. | Moreno JI et al. | β | 1994 | β |
| Modulation of GABAC receptors in rat retinal bipolar cells by protein kinase C. | Feigenspan A et al. | β | 1994 | β |
| Molecular neurobiology of the GABAA receptor. | Dunn SM et al. | β | 1994 | β |
| Organization of the mouse 5-HT3 receptor gene and functional expression of two splice variants. | Werner P et al. | β | 1994 | β |
| Phenotypic consequences of deletion of the gamma 3, alpha 5, or beta 3 subunit of the type A gamma-aminobutyric acid receptor in mice. | Culiat CT et al. | β | 1994 | β |
| Search for mutations in the beta 1 GABAA receptor subunit gene in patients with schizophrenia. | Coon H et al. | β | 1994 | β |
| A novel invertebrate GABAA receptor-like polypeptide. Sequence and pattern of gene expression. | Hutton ML et al. | β | 1993 | β |
| Functional heterogeneity of hippocampal GABAA receptors. | SchΓΆnrock B et al. | β | 1993 | β |
| GABA rho 2 receptor pharmacological profile: GABA recognition site similarities to rho 1. | Kusama T et al. | β | 1993 | β |
| High-resolution mapping of the gamma-aminobutyric acid receptor subunit beta 3 and alpha 5 gene cluster on chromosome 15q11-q13, and localization of breakpoints in two Angelman syndrome patients. | Sinnett D et al. | β | 1993 | β |
| Molecular cloning reveals the existence of a fourth gamma subunit of the vertebrate brain GABAA receptor. | Harvey RJ et al. | β | 1993 | β |
| Invertebrate GABA and glutamate receptors: molecular biology reveals predictable structures but some unusual pharmacologies. | Darlison MG | β | 1992 | β |
| Receptor classes and the transmitter-gated ion channels. | Barnard EA | β | 1992 | β |