Neuronal activity-dependent cell survival mediated by transcription factor MEF2.
paper
Cited
Public
Unavailable
- Authors
- Mao, Z; Bonni, A; Xia, F; Nadal-Vicens, M; Greenberg, M E
- Year
- 1999
- Journal
- Science (New York, N.Y.)
- PMID
- 10531066
- DOI
- 10.1126/science.286.5440.785
During mammalian development, electrical activity promotes the calcium-dependent survival of neurons that have made appropriate synaptic connections. However, the mechanisms by which calcium mediates neuronal survival during development are not well characterized. A transcription-dependent mechanism was identified by which calcium influx into neurons promoted cell survival. The transcription factor MEF2 was selectively expressed in newly generated postmitotic neurons and was required for the survival of these neurons. Calcium influx into cerebellar granule neurons led to activation of p38 mitogen-activated protein kinase-dependent phosphorylation and activation of MEF2. Once activated, MEF2 regulated neuronal survival by stimulating MEF2-dependent gene transcription. These findings demonstrate that MEF2 is a calcium-regulated transcription factor and define a function for MEF2 during nervous system development that is distinct from previously well-characterized functions of MEF2 during muscle differentiation.
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| Human spongiosa mesenchymal stem cells fail to generate cardiomyocytes in vitro. | Mastitskaya S et al. | β | 2009 | β |
| Localization of myocyte enhancer factor 2 in the rodent forebrain: regionally-specific cytoplasmic expression of MEF2A. | Neely MD et al. | β | 2009 | β |
| Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity. | Zhang SJ et al. | β | 2009 | β |
| Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription in NMDA receptor-stimulated cortical neurons. | Vashishta A et al. | β | 2009 | β |
| p38alpha- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress. | Seifert A et al. | β | 2009 | β |
| Parkinson's disease: to live or die by autophagy. | Irrcher I et al. | β | 2009 | β |
| Phosphorylation of neuronal survival factor MEF2D by glycogen synthase kinase 3beta in neuronal apoptosis. | Wang X et al. | β | 2009 | β |
| Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. | Yang Q et al. | β | 2009 | β |
| Soman poisoning alters p38 MAPK pathway in rat cerebellar Purkinje cells. | Pejchal J et al. | β | 2009 | β |
| Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells. | Liu GH et al. | β | 2009 | β |
| A brief history of neuronal gene expression: regulatory mechanisms and cellular consequences. | Qiu Z et al. | β | 2008 | β |
| A Golgi fragmentation pathway in neurodegeneration. | Nakagomi S et al. | β | 2008 | β |
| A postpartum model in rat: behavioral and gene expression changes induced by ovarian steroid deprivation. | Suda S et al. | β | 2008 | β |
| Ca2+-operated transcriptional networks: molecular mechanisms and in vivo models. | MellstrΓΆm B et al. | β | 2008 | β |
| Cocaine regulates MEF2 to control synaptic and behavioral plasticity. | Pulipparacharuvil S et al. | β | 2008 | β |
| Critical role of type 2 ryanodine receptor in mediating activity-dependent neurogenesis from embryonic stem cells. | Yu HM et al. | β | 2008 | β |
| Cultures of cerebellar granule neurons. | Bilimoria PM et al. | β | 2008 | β |
| MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. | Barbosa AC et al. | β | 2008 | β |
| Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells. | Li Z et al. | β | 2008 | β |
| Neural activity-dependent regulation of gene expression in developing and mature neurons. | Abe K | β | 2008 | β |
| Neuronal activity enhances aryl hydrocarbon receptor-mediated gene expression and dioxin neurotoxicity in cortical neurons. | Lin CH et al. | β | 2008 | β |
| Overexpression of myocyte enhancer factor 2 and histone hyperacetylation in hepatocellular carcinoma. | Bai X et al. | β | 2008 | β |
| Protein kinase A represses skeletal myogenesis by targeting myocyte enhancer factor 2D. | Du M et al. | β | 2008 | β |
| Small-molecule activation of neuronal cell fate. | Schneider JW et al. | β | 2008 | β |
| Targeting excitotoxic/free radical signaling pathways for therapeutic intervention in glaucoma. | Seki M et al. | β | 2008 | β |
| The nerve growth factor and its receptors in airway inflammatory diseases. | Freund-Michel V et al. | β | 2008 | β |
| Therapeutic application of histone deacetylase inhibitors for central nervous system disorders. | Kazantsev AG et al. | β | 2008 | β |
| The role of Akt-GSK-3beta signaling and synaptic strength in phencyclidine-induced neurodegeneration. | Lei G et al. | β | 2008 | β |
| Translating neuronal activity into dendrite elaboration: signaling to the nucleus. | Redmond L | β | 2008 | β |
| A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. | Boutz PL et al. | β | 2007 | β |
| Brain-derived neurotrophic factor stimulates the transcriptional and neuroprotective activity of myocyte-enhancer factor 2C through an ERK1/2-RSK2 signaling cascade. | Wang Y et al. | β | 2007 | β |
| c-Jun N-terminal protein kinase signalling pathway mediates lovastatin-induced rat brain neuroblast apoptosis. | Cerezo-Guisado MI et al. | β | 2007 | β |
| Control of the SOST bone enhancer by PTH using MEF2 transcription factors. | Leupin O et al. | β | 2007 | β |
| Cooperative transformation by MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins generated by the variant t(1;19) in acute lymphoblastic leukemia. | Prima V et al. | β | 2007 | β |
| Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation. | Ramachandiran S et al. | β | 2007 | β |
| Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity. | Dong J et al. | β | 2007 | β |
| KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC. | van der Linden AM et al. | β | 2007 | β |
| Localization of the transcriptional coactivator PGC-1alpha to GABAergic neurons during maturation of the rat brain. | Cowell RM et al. | β | 2007 | β |
| Mechanism of MASH1 induction by ASK1 and ATRA in adult neural progenitors. | Elmi M et al. | β | 2007 | β |
| MEF2: a central regulator of diverse developmental programs. | Potthoff MJ et al. | β | 2007 | β |
| MEF2D expression increases during neuronal differentiation of neural progenitor cells and correlates with neurite length. | Lam BY et al. | β | 2007 | β |
| Myocyte enhancing factor-2A in Alzheimer's disease: genetic analysis and association with MEF2A-polymorphisms. | GonzΓ‘lez P et al. | β | 2007 | β |
| Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development. | Satoh K et al. | β | 2007 | β |
| Neuroprotective effect of TNFalpha against the beta-amyloid neurotoxicity mediated by CDK5 kinase. | Orellana DI et al. | β | 2007 | β |
| PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis. | Shalizi A et al. | β | 2007 | β |
| Porcine maternal infanticide as a model for puerperal psychosis. | Quilter CR et al. | β | 2007 | β |
| Repression of BCL-6 is required for the formation of human memory B cells in vitro. | Kuo TC et al. | β | 2007 | β |
| The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2. | Bolger TA et al. | β | 2007 | β |
| The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells. | Obara Y et al. | β | 2007 | β |
| Transcriptional regulation of vertebrate axon guidance and synapse formation. | Polleux F et al. | β | 2007 | β |
| A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. | Shalizi A et al. | β | 2006 | β |
| Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. | Flavell SW et al. | β | 2006 | β |
| CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels. | Gao L et al. | β | 2006 | β |
| Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation. | GrΓ©goire S et al. | β | 2006 | β |
| Differential effects of Ca2+ and cAMP on transcription mediated by MEF2D and cAMP-response element-binding protein in hippocampal neurons. | Belfield JL et al. | β | 2006 | β |
| Distribution of constitutively expressed MEF-2A in adult rat and human nervous systems. | Ruffle RA et al. | β | 2006 | β |
| From structural biochemistry to expression profiling: neuroprotective activities of estrogen. | Manthey D et al. | β | 2006 | β |
| Histone deacetylase inhibitors as therapeutics for polyglutamine disorders. | Butler R et al. | β | 2006 | β |
| MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field. | Vong L et al. | β | 2006 | β |
| Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. | Luckey CJ et al. | β | 2006 | β |
| Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. | Xu J et al. | β | 2006 | β |
| Neuroprotective effect of N-acetylcysteine on neuronal apoptosis induced by a synthetic gingerdione compound: involvement of ERK and p38 phosphorylation. | Lin CH et al. | β | 2006 | β |
| Neuroprotective role of ERK1/2 and ERK5 in a dopaminergic cell line under basal conditions and in response to oxidative stress. | Cavanaugh JE et al. | β | 2006 | β |
| Noxious cold stimulation induces mitogen-activated protein kinase activation in transient receptor potential (TRP) channels TRPA1- and TRPM8-containing small sensory neurons. | Mizushima T et al. | β | 2006 | β |
| Role of L-type Ca2+ channels in neural stem/progenitor cell differentiation. | D'Ascenzo M et al. | β | 2006 | β |
| The C terminus of the L-type voltage-gated calcium channel Ca(V)1.2 encodes a transcription factor. | Gomez-Ospina N et al. | β | 2006 | β |
| The role of oxidative stress in the dysregulation of gene expression and protein metabolism in neurodegenerative disease. | Potashkin JA et al. | β | 2006 | β |
| The stop signal revised: immature cerebellar granule neurons in the external germinal layer arrest pontine mossy fiber growth. | Manzini MC et al. | β | 2006 | β |
| Thrombin-induced autoinhibitory factor, Down syndrome critical region-1, attenuates NFAT-dependent vascular cell adhesion molecule-1 expression and inflammation in the endothelium. | Minami T et al. | β | 2006 | β |
| Why photoreceptors die (and why they don't). | Fain GL | β | 2006 | β |
| Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo. | Abell AN et al. | β | 2005 | β |
| Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia. | Mizushima T et al. | β | 2005 | β |
| Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain. | Zhu B et al. | β | 2005 | β |
| A novel role for extracellular signal-regulated kinase 5 and myocyte enhancer factor 2 in medulloblastoma cell death. | Sturla LM et al. | β | 2005 | β |
| Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. | GrΓ©goire S et al. | β | 2005 | β |
| brawn for brains: the role of MEF2 proteins in the developing nervous system. | Shalizi AK et al. | β | 2005 | β |
| Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia. | Prima V et al. | β | 2005 | β |
| Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2. | Tang X et al. | β | 2005 | β |
| Generation of conditional Mef2cloxP/loxP mice for temporal- and tissue-specific analyses. | Vong LH et al. | β | 2005 | β |
| Genes regulated in neurons undergoing transcription-dependent apoptosis belong to signaling pathways rather than the apoptotic machinery. | Desagher S et al. | β | 2005 | β |
| Implication of cyclin-dependent kinase 5 in the neuroprotective properties of lithium. | JordΓ EG et al. | β | 2005 | β |
| Inhibition of multiple pathways accounts for the antiapoptotic effects of flavopiridol on potassium withdrawal-induced apoptosis in neurons. | Verdaguer E et al. | β | 2005 | β |
| Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death. | Bolger TA et al. | β | 2005 | β |
| Ion channel development, spontaneous activity, and activity-dependent development in nerve and muscle cells. | Moody WJ et al. | β | 2005 | β |
| Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2. | Han A et al. | β | 2005 | β |
| Mechanisms of retinotopic map development: Ephs, ephrins, and spontaneous correlated retinal activity. | O'Leary DD et al. | β | 2005 | β |
| Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation. | Ma K et al. | β | 2005 | β |
| Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection. | Papadia S et al. | β | 2005 | β |
| PI3K/Akt-dependent regulation of the transcription factor myocyte enhancer factor-2 in insulin-like growth factor-1- and membrane depolarization-mediated survival of cerebellar granule neurons. | Wiedmann M et al. | β | 2005 | β |
| Postadolescent changes in regional cerebral protein synthesis: an in vivo study in the FMR1 null mouse. | Qin M et al. | β | 2005 | β |
| Proteasome inhibition elicits a biphasic effect on neuronal apoptosis via differential regulation of pro-survival and pro-apoptotic transcription factors. | Butts BD et al. | β | 2005 | β |
| Region-specific phosphorylation of ERK5-MEF2C in the rat frontal cortex and hippocampus after electroconvulsive shock. | Yoon SC et al. | β | 2005 | β |
| Regulation of neuroprotective activity of myocyte-enhancer factor 2 by cAMP-protein kinase A signaling pathway in neuronal survival. | Wang X et al. | β | 2005 | β |
| Regulation of vertebrate myotome development by the p38 MAP kinase-MEF2 signaling pathway. | de Angelis L et al. | β | 2005 | β |
| The transcription factor NFAT3 mediates neuronal survival. | Benedito AB et al. | β | 2005 | β |
| Activation of ERK5 is mediated by N-methyl-D-aspartate receptor and L-type voltage-gated calcium channel via Src involving oxidative stress after cerebral ischemia in rat hippocampus. | Wang RM et al. | β | 2004 | β |
| A screen for downstream effectors of Neurogenin2 in the embryonic neocortex. | Mattar P et al. | β | 2004 | β |
| Attenuation of fasting-induced phosphorylation of mitogen-activated protein kinases (ERK/p38) in the mouse hypothalamus in response to refeeding. | Ueyama E et al. | β | 2004 | β |
| Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach. | Ogden CA et al. | β | 2004 | β |
| Caspase-dependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosis. | Paroni G et al. | β | 2004 | β |
| Caspase-mediated specific cleavage of human histone deacetylase 4. | Liu F et al. | β | 2004 | β |
| Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells. | Uddin S et al. | β | 2004 | β |
| Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death. | Cao J et al. | β | 2004 | β |
| Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. | Haeseleer F et al. | β | 2004 | β |
| Excitation-neurogenesis coupling in adult neural stem/progenitor cells. | Deisseroth K et al. | β | 2004 | β |
| Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1. | Lomonte P et al. | β | 2004 | β |
| Gene regulation and DNA damage in the ageing human brain. | Lu T et al. | β | 2004 | β |
| Granule neurons in cerebellum express distinct splice variants of the inositol trisphosphate receptor that are modulated by calcium. | Choi JY et al. | β | 2004 | β |
| High K+ and IGF-1 protect cerebellar granule neurons via distinct signaling pathways. | Zhong J et al. | β | 2004 | β |
| Identification of calcium- and nitric oxide-regulated genes by differential analysis of library expression (DAzLE). | Li H et al. | β | 2004 | β |
| Identification of MEF2-regulated genes during muscle differentiation. | Paris J et al. | β | 2004 | β |
| Intergenomic consensus in multifactorial inheritance loci: the case of multiple sclerosis. | Serrano-FernΓ‘ndez P et al. | β | 2004 | β |
| L-type calcium channels: the low down. | Lipscombe D et al. | β | 2004 | β |
| MAPK activation in nociceptive neurons and pain hypersensitivity. | Obata K et al. | β | 2004 | β |
| Mitogen-activated protein kinases in apoptosis regulation. | Wada T et al. | β | 2004 | β |
| Myocyte enhancer factor 2 mediates vascular inflammation via the p38-dependent pathway. | Suzuki E et al. | β | 2004 | β |
| Myocyte enhancer factor-2 transcription factors in neuronal differentiation and survival. | Heidenreich KA et al. | β | 2004 | β |
| Phosphorylation and alternative pre-mRNA splicing converge to regulate myocyte enhancer factor 2C activity. | Zhu B et al. | β | 2004 | β |
| Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2. | Wang X et al. | β | 2004 | β |
| Role of calcium and kinases on the neurotrophic effect induced by gamma-aminobutyric acid. | Fiszman ML et al. | β | 2004 | β |
| Role of extracellular signal regulated kinase 5 in neuronal survival. | Cavanaugh JE | β | 2004 | β |
| The biochemical activation of T-type Ca2+ channels in HEK293 cells stably expressing alpha1G and Kir2.1 subunits. | Kim T et al. | β | 2004 | β |
| The Gtx homeodomain transcription factor exerts neuroprotection using its homeodomain. | Hashimoto Y et al. | β | 2004 | β |
| Time-dependent changes in the expression of the MEF2 transcription factor family during topographic map reorganization in mammalian visual cortex. | Leysen I et al. | β | 2004 | β |
| Undermining the endothelium by ablation of MAPK-MEF2 signaling. | Olson EN | β | 2004 | β |
| Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis. | Minami T et al. | β | 2004 | β |
| Activation of JNK by vanadate induces a Fas-associated death domain (FADD)-dependent death of cerebellar granule progenitors in vitro. | Luo J et al. | β | 2003 | β |
| Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. | Ono T et al. | β | 2003 | β |
| A myocyte enhancer factor 2D (MEF2D) kinase activated during neuronal apoptosis is a novel target inhibited by lithium. | Linseman DA et al. | β | 2003 | β |
| Calcineurin regulation of neuronal plasticity. | Groth RD et al. | β | 2003 | β |
| Calcium channel and NMDA receptor activities differentially regulate nuclear C/EBPbeta levels to control neuronal survival. | Marshall J et al. | β | 2003 | β |
| Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. | Gong X et al. | β | 2003 | β |
| Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern. | Shalizi A et al. | β | 2003 | β |
| Chick RGS2L demonstrates concentration-dependent selectivity for pertussis toxin-sensitive and -insensitive pathways that inhibit L-type Ca2+ channels. | Tosetti P et al. | β | 2003 | β |
| Class II histone deacetylases: versatile regulators. | Verdin E et al. | β | 2003 | β |
| Dynamic gene expression during the onset of myoblast differentiation in vitro. | Delgado I et al. | β | 2003 | β |
| ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons. | Liu L et al. | β | 2003 | β |
| GABA-induced neurite outgrowth of cerebellar granule cells is mediated by GABA(A) receptor activation, calcium influx and CaMKII and erk1/2 pathways. | Borodinsky LN et al. | β | 2003 | β |
| Hypertonicity promotes survival of corticospinal motoneurons via mitogen-activated protein kinase p38 signaling. | Junger H et al. | β | 2003 | β |
| Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival. | Linseman DA et al. | β | 2003 | β |
| Interactions with PDZ proteins are required for L-type calcium channels to activate cAMP response element-binding protein-dependent gene expression. | Weick JP et al. | β | 2003 | β |
| K+-dependent cerebellar granule neuron apoptosis. Role of task leak K+ channels. | Lauritzen I et al. | β | 2003 | β |
| MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils. | Coxon PY et al. | β | 2003 | β |
| Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress. | Cowan KJ et al. | β | 2003 | β |
| Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5. | Chawla S et al. | β | 2003 | β |
| NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. | Delcroix JD et al. | β | 2003 | β |
| Opposing roles of synaptic and extrasynaptic NMDA receptors in neuronal calcium signalling and BDNF gene regulation. | Vanhoutte P et al. | β | 2003 | β |
| Phosphorylation motifs regulating the stability and function of myocyte enhancer factor 2A. | Cox DM et al. | β | 2003 | β |
| Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2. | Han A et al. | β | 2003 | β |
| Signaling from synapse to nucleus: the logic behind the mechanisms. | Deisseroth K et al. | β | 2003 | β |
| Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons. | Chen WG et al. | β | 2003 | β |
| A 4-Mb critical region for intrauterine growth retardation at 15q26. | Harada N et al. | β | 2002 | β |
| A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. | Tao X et al. | β | 2002 | β |
| Angiotensin II induces myocyte enhancer factor 2- and calcineurin/nuclear factor of activated T cell-dependent transcriptional activation in vascular myocytes. | Suzuki E et al. | β | 2002 | β |
| Anti-apoptotic wild-type Alzheimer amyloid precursor protein signaling involves the p38 mitogen-activated protein kinase/MEF2 pathway. | Burton TR et al. | β | 2002 | β |
| Characterization of CeHDA-7, a class II histone deacetylase interacting with MEF-2 in Caenorhabditis elegans. | Choi KY et al. | β | 2002 | β |
| c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons. | Coffey ET et al. | β | 2002 | β |
| Contribution of Ca2+ calmodulin-dependent protein kinase II and mitogen-activated protein kinase kinase to neural activity-induced neurite outgrowth and survival of cerebellar granule cells. | Borodinsky LN et al. | β | 2002 | β |
| Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. | Okamoto S et al. | β | 2002 | β |
| Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. | Lock C et al. | β | 2002 | β |
| Global analysis of gene expression patterns in developing mouse neocortex using serial analysis of gene expression. | Gunnersen JM et al. | β | 2002 | β |
| Identification of inhibitor-of-differentiation 2 (Id2) as a modulator of neuronal apoptosis. | Gleichmann M et al. | β | 2002 | β |
| Inhibitory molecules in signal transduction pathways of cardiac hypertrophy. | Takano H et al. | β | 2002 | β |
| Involvement of an upstream stimulatory factor as well as cAMP-responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I. | Tabuchi A et al. | β | 2002 | β |
| Location, location, location: a spatial view of neurotrophin signal transduction. | Heerssen HM et al. | β | 2002 | β |
| MEF2: a calcium-dependent regulator of cell division, differentiation and death. | McKinsey TA et al. | β | 2002 | β |
| Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system. | Takeda K et al. | β | 2002 | β |
| p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. | Ji RR et al. | β | 2002 | β |
| Regulation of gene expression by Ca2+ signals in neuronal cells. | Chawla S | β | 2002 | β |
| Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+). | Ojuka EO et al. | β | 2002 | β |
| Regulation of transcription factors by neuronal activity. | West AE et al. | β | 2002 | β |
| Retinal ganglion cells do not extend axons by default: promotion by neurotrophic signaling and electrical activity. | Goldberg JL et al. | β | 2002 | β |
| RNA interference reveals a requirement for myocyte enhancer factor 2A in activity-dependent neuronal survival. | Gaudilliere B et al. | β | 2002 | β |
| 14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation. | Choi SJ et al. | β | 2001 | β |
| Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway. | Wu H et al. | β | 2001 | β |
| Activation of p38MAPK by TGF-beta in fetal rat hepatocytes requires radical oxygen production, but is dispensable for cell death. | Herrera B et al. | β | 2001 | β |
| An essential role for Rac/Cdc42 GTPases in cerebellar granule neuron survival. | Linseman DA et al. | β | 2001 | β |
| AP-1 proteins in the adult brain: facts and fiction about effectors of neuroprotection and neurodegeneration. | Herdegen T et al. | β | 2001 | β |
| Calcium, calcineurin, and the control of transcription. | Crabtree GR | β | 2001 | β |
| Calcium regulation of neuronal gene expression. | West AE et al. | β | 2001 | β |
| Class II histone deacetylases: structure, function, and regulation. | Bertos NR et al. | β | 2001 | β |
| Defining Ca2+/calmodulin-dependent protein kinase cascades in transcriptional regulation. | Corcoran EE et al. | β | 2001 | β |
| Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons. | Cavanaugh JE et al. | β | 2001 | β |
| Functional regulatory regions of human transcription factor MEF2C. | Janson CG et al. | β | 2001 | β |
| G-protein-coupled receptors and signaling networks: emerging paradigms. | Marinissen MJ et al. | β | 2001 | β |
| Hyperthermia induces gene expression of heat shock protein 70 and phosphorylation of mitogen activated protein kinases in the rat cerebellum. | Schiaffonati L et al. | β | 2001 | β |
| Identification of a signal-responsive nuclear export sequence in class II histone deacetylases. | McKinsey TA et al. | β | 2001 | β |
| MAP kinases. | Chen Z et al. | β | 2001 | β |
| Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7. | Kao HY et al. | β | 2001 | β |
| Mechanisms of Ca(2+)-dependent transcription. | MellstrΓΆm B et al. | β | 2001 | β |
| Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons. | Li M et al. | β | 2001 | β |
| Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines. | Xu W et al. | β | 2001 | β |
| Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain. | Ji RR et al. | β | 2001 | β |
| Neurotrophins use the Erk5 pathway to mediate a retrograde survival response. | Watson FL et al. | β | 2001 | β |
| Rapidly exchanging Ca2+ stores in neurons: molecular, structural and functional properties. | Meldolesi J | β | 2001 | β |
| Resistance to tumor necrosis factor-induced cell death mediated by PMCA4 deficiency. | Ono K et al. | β | 2001 | β |
| SB203580 promotes EGF-stimulated early morphological differentiation in PC12 cell through activating ERK pathway. | New L et al. | β | 2001 | β |
| Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. | Dolmetsch RE et al. | β | 2001 | β |
| Signal transduction by target-derived neurotrophins. | Whitmarsh AJ et al. | β | 2001 | β |
| The emerging role of class II histone deacetylases. | Fischle W et al. | β | 2001 | β |
| The nuclear localization domain of the MEF2 family of transcription factors shows member-specific features and mediates the nuclear import of histone deacetylase 4. | Borghi S et al. | β | 2001 | β |
| Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation. | Okamoto S et al. | β | 2000 | β |
| Apoptosis in the nervous system. | Yuan J et al. | β | 2000 | β |
| A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. | Rothermel B et al. | β | 2000 | β |
| Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. | Namgung U et al. | β | 2000 | β |
| Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2. | Youn HD et al. | β | 2000 | β |
| Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4. | Youn HD et al. | β | 2000 | β |
| CREB couples neurotrophin signals to survival messages. | Finkbeiner S | β | 2000 | β |
| Crystal structure of MEF2A core bound to DNA at 1.5 A resolution. | Santelli E et al. | β | 2000 | β |
| Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3-CA1 synapses. | Bolshakov VY et al. | β | 2000 | β |
| GATA-dependent recruitment of MEF2 proteins to target promoters. | Morin S et al. | β | 2000 | β |
| MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. | Wu H et al. | β | 2000 | β |
| Neural activity and survival in the developing nervous system. | Mennerick S et al. | β | 2000 | β |
| p38 MAP kinases: beyond the stress response. | Nebreda AR et al. | β | 2000 | β |
| p38 mitogen-activated protein kinase mediates tumor necrosis factor-alpha-induced apoptosis in rat fetal brown adipocytes. | Valladares A et al. | β | 2000 | β |
| Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. | Lu J et al. | β | 2000 | β |
| SDF-1alpha-mediated modulation of synaptic transmission in rat cerebellum. | Limatola C et al. | β | 2000 | β |
| Solution structure of the MEF2A-DNA complex: structural basis for the modulation of DNA bending and specificity by MADS-box transcription factors. | Huang K et al. | β | 2000 | β |
| The MADS-Box factor CeMEF2 is not essential for Caenorhabditis elegans myogenesis and development. | Dichoso D et al. | β | 2000 | β |