Stress, corticotropin-releasing factor, and drug addiction.
paper
Cited
Public
Unavailable
- Authors
- Koob, G F
- Year
- 1999
- Journal
- Annals of the New York Academy of Sciences
- PMID
- 10676433
- DOI
- 10.1111/j.1749-6632.1999.tb07876.x
The neuropeptide corticotropin-releasing factor (CRE) and related neuropeptides not only mediate hormonal responses to stressors but also have a neurotropic role in the central nervous system to mediate behavioral responses to stressors. CRF antagonists effectively block CRF responses and have effects opposite those of CRF in many stress-related situations. Recent advances suggest that in addition to CRF itself there is another CRF-related neuropeptide, urocortin, that may be involved in stress-related responses, particularly those involving appetite. At least two CRF receptors have been discovered to date, CRF-1 and CRF-2. CRF may be involved in various aspects of the addiction cycle associated with drugs of abuse. CRF appears to be activated during stress-induced reinstatement of drug taking as well as acute withdrawal from all major drugs of abuse. CRF is hypothesized to be part of an allostatic change leading to vulnerability to relapse during prolonged abstinence from drugs of abuse.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Functional interaction between orexin/CRF and orexin/dynorphin transmission in the infralimbic cortex modulates the stress-induced reinstatement of alcohol-seeking behavior in male and female Wistar rats. | Flores-Ramirez FJ et al. | β | 2026 | β |
| Alcohol Attenuates CRF-Induced Excitatory Effects from the Extended Amygdala to Dorsostriatal Cholinergic Interneurons | Essoh A et al. | β | 2025 | β |
| A review of kappa opioid receptor antagonists and their clinical trial landscape. | Lobe MMM et al. | β | 2025 | β |
| From Stress to Substance Use Disorders: The Expanding Role of Microglia-Astrocyte Crosstalk in Neuroimmune and Glutamate Alterations in the Nucleus Accumbens. | Cancela LM et al. | β | 2025 | β |
| Adolescent social isolation induced alterations in nucleus accumbens glutamate signalling. | Deutschmann AU et al. | β | 2022 | β |
| Kappa Opioid Receptor Blockade in the Amygdala Mitigates Pain Like-Behaviors by Inhibiting Corticotropin Releasing Factor Neurons in a Rat Model of Functional Pain. | Yakhnitsa V et al. | β | 2022 | β |
| Moderate prenatal alcohol exposure modifies sex-specific CRFR1 activity in the central amygdala and anxiety-like behavior in adolescent offspring. | Rouzer SK et al. | β | 2022 | β |
| Caveolin-1 Expression in the Dorsal Striatum Drives Methamphetamine Addiction-Like Behavior. | Avchalumov Y et al. | β | 2021 | β |
| CRF-5-HT interactions in the dorsal raphe nucleus and motivation for stress-induced opioid reinstatement. | Li C et al. | β | 2021 | β |
| Exercise Pills for Drug Addiction: Forced Moderate Endurance Exercise Inhibits Methamphetamine-Induced Hyperactivity through the Striatal Glutamatergic Signaling Pathway in Male Sprague Dawley Rats. | Jung S et al. | β | 2021 | β |
| Assessing international alcohol consumption patterns during isolation from the COVID-19 pandemic using an online survey: highlighting negative emotionality mechanisms. | Sallie SN et al. | β | 2020 | β |
| Non-pharmacological factors that determine drug use and addiction. | Ahmed SH et al. | β | 2020 | β |
| Sexual Differentiation and Substance Use: A Mini-Review. | Harp SJ et al. | β | 2020 | β |
| The role of catecholamines in modulating responses to stress: Sex-specific patterns, implications, and therapeutic potential for post-traumatic stress disorder and opiate withdrawal. | Ross JA et al. | β | 2020 | β |
| A meta-analysis of emotional disorders as possible risk factors for chronic periodontitis. | Liu F et al. | β | 2018 | β |
| Behavioral and Biochemical Impact of Chronic Unpredictable Mild Stress on the Acquisition of Nicotine Conditioned Place Preference in Rats. | Biala G et al. | β | 2018 | β |
| The role of hippocampal adult neurogenesis in methamphetamine addiction. | Takashima Y et al. | β | 2018 | β |
| Escalated cocaine "binges" in rats: enduring effects of social defeat stress or intra-VTA CRF. | Leonard MZ et al. | β | 2017 | β |
| Localization of the delta opioid receptor and corticotropin-releasing factor in the amygdalar complex: role in anxiety. | Reyes BAS et al. | β | 2017 | β |
| Neuropeptide systems and new treatments for nicotine addiction. | Bruijnzeel AW | β | 2017 | β |
| Psychological stress has a higher rate of developing addictive behaviors compared to physical stress in rat offspring. | Nazeri M et al. | β | 2017 | β |
| Etiological theories of addiction: A comprehensive update on neurobiological, genetic and behavioural vulnerability. | Ouzir M et al. | β | 2016 | β |
| Norepinephrine at the nexus of arousal, motivation and relapse. | EspaΓ±a RA et al. | β | 2016 | β |
| Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses. | Bonnavion P et al. | β | 2015 | β |
| Evaluating Exercise as a Therapeutic Intervention for Methamphetamine Addiction-Like Behavior. | Somkuwar SS et al. | β | 2015 | β |
| Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment. | Crowley NA et al. | β | 2015 | β |
| Role of DNA methylation in the nucleus accumbens in incubation of cocaine craving. | Massart R et al. | β | 2015 | β |
| Effect of baclofen on morphine-induced conditioned place preference, extinction, and stress-induced reinstatement in chronically stressed mice. | Meng S et al. | β | 2014 | β |
| Effects of cocaine on the hypothalamic-pituitary-adrenal axis. | Manetti L et al. | β | 2014 | β |
| Persistent pain facilitates response to morphine reward by downregulation of central amygdala GABAergic function. | Zhang Z et al. | β | 2014 | β |
| Personality traits modulate emotional and physiological responses to stress. | Childs E et al. | β | 2014 | β |
| Role of NG2 expressing cells in addiction: a new approach for an old problem. | Somkuwar SS et al. | β | 2014 | β |
| Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration. | Boyson CO et al. | β | 2014 | β |
| Adaptations in brain reward circuitry underlie palatable food cravings and anxiety induced by high-fat diet withdrawal. | Sharma S et al. | β | 2013 | β |
| Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use, and compulsive smoking. | Cohen A et al. | β | 2013 | β |
| Critical need for family-based, quasi-experimental designs in integrating genetic and social science research. | D'Onofrio BM et al. | β | 2013 | β |
| Development of ΞΊ opioid receptor antagonists. | Carroll FI et al. | β | 2013 | β |
| Familial confounding of the association between maternal smoking during pregnancy and offspring substance use and problems. | D'Onofrio BM et al. | β | 2012 | β |
| [Impairment of emotional behaviors induced by early postnatal stress]. | Yamaguchi T et al. | β | 2012 | β |
| Salivary alpha-amylase and cortisol in infancy and toddlerhood: direct and indirect relations with executive functioning and academic ability in childhood. | Berry D et al. | β | 2012 | β |
| Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis. | Becker JB et al. | β | 2012 | β |
| Stress and addiction: contribution of the corticotropin releasing factor (CRF) system in neuroplasticity. | Haass-Koffler CL et al. | β | 2012 | β |
| The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery. | Mandyam CD et al. | β | 2012 | β |
| The effects of repeated corticosterone exposure on the interoceptive effects of alcohol in rats. | Besheer J et al. | β | 2012 | β |
| Tobacco addiction and the dysregulation of brain stress systems. | Bruijnzeel AW | β | 2012 | β |
| Addiction and brain reward and antireward pathways. | Gardner EL | β | 2011 | β |
| CRFβ mediates the increased noradrenergic activity in the hypothalamic paraventricular nucleus and the negative state of morphine withdrawal in rats. | Navarro-Zaragoza J et al. | β | 2011 | β |
| Drugs as instruments: a new framework for non-addictive psychoactive drug use. | MΓΌller CP et al. | β | 2011 | β |
| Eugenol as an anti-stress agent: modulation of hypothalamic-pituitary-adrenal axis and brain monoaminergic systems in a rat model of stress. | Garabadu D et al. | β | 2011 | β |
| Exposure to a high-fat diet decreases sensitivity to Ξ9-tetrahydrocannabinol-induced motor effects in female rats. | Wiley JL et al. | β | 2011 | β |
| Increased sensitivity to the effects of chronic social defeat stress in an innately anxious mouse strain. | Savignac HM et al. | β | 2011 | β |
| Induction of multiple reinstatements of ethanol- and sucrose-seeking behavior in Long-Evans rats by the Ξ±-2 adrenoreceptor antagonist yohimbine. | Simms JA et al. | β | 2011 | β |
| Risperidone in ultra low dose protects against stress in the rodent cold restraint model by modulating stress pathways. | Krishnamurthy S et al. | β | 2011 | β |
| Vulnerability to nicotine abstinence-related social anxiety-like behavior: molecular correlates in neuropeptide Y, Y2 receptor and corticotropin releasing factor. | Aydin C et al. | β | 2011 | β |
| Alcohol consumption enhances antiretroviral painful peripheral neuropathy by mitochondrial mechanisms. | Ferrari LF et al. | β | 2010 | β |
| Brain neuropeptide Y and corticotropin-releasing hormone in mediating stress and anxiety. | Thorsell A | β | 2010 | β |
| Delineating the psychic structure of substance abuse and addictions: should anxiety, mood and impulse-control dysregulation be included? | Pani PP et al. | β | 2010 | β |
| Differential effects of allopregnanolone on the escalation of cocaine self-administration and sucrose intake in female rats. | Anker JJ et al. | β | 2010 | β |
| Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal. | Navarro-Zaragoza J et al. | β | 2010 | β |
| Long-Evans rats acquire operant self-administration of 20% ethanol without sucrose fading. | Simms JA et al. | β | 2010 | β |
| Molecular and genetic substrates linking stress and addiction. | Briand LA et al. | β | 2010 | β |
| Neurofeedback Effects on Evoked and Induced EEG Gamma Band Reactivity to Drug-related Cues in Cocaine Addiction. | Horrell T et al. | β | 2010 | β |
| Neuroplastic alterations in the limbic system following cocaine or alcohol exposure. | Stuber GD et al. | β | 2010 | β |
| Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. | Chen AC et al. | β | 2010 | β |
| The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. | Wee S et al. | β | 2010 | β |
| Increased perioculomotor urocortin 1 immunoreactivity in genetically selected alcohol preferring rats. | Fonareva I et al. | β | 2009 | β |
| Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond. | Ciccocioppo R et al. | β | 2009 | β |
| What do midwives need to understand/know about smoking in pregnancy? | Ebert L et al. | β | 2009 | β |
| Addiction and arousal: the hypocretin connection. | Boutrel B et al. | β | 2008 | β |
| A neuropeptide-centric view of psychostimulant addiction. | Boutrel B | β | 2008 | β |
| Attentional Bias to Drug- and Stress-Related Pictorial Cues in Cocaine Addiction Comorbid with PTSD. | Sokhadze E et al. | β | 2008 | β |
| Behavioral characteristics and neurobiological substrates shared by Pavlovian sign-tracking and drug abuse. | Tomie A et al. | β | 2008 | β |
| CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats. | Specio SE et al. | β | 2008 | β |
| Dopamine and corticotropin-releasing factor synergistically alter basolateral amygdala-to-medial prefrontal cortex synaptic transmission: functional switch after chronic cocaine administration. | Orozco-Cabal L et al. | β | 2008 | β |
| Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats. | Richards JK et al. | β | 2008 | β |
| Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence. | Smith RJ et al. | β | 2008 | β |
| Pharmacotherapy of methamphetamine addiction: an update. | Elkashef A et al. | β | 2008 | β |
| Regulation of extracellular signal-regulated kinases (ERKs) by naloxone-induced morphine withdrawal in the brain stress system. | NΓΊΓ±ez C et al. | β | 2008 | β |
| Repeated intracerebral teneurin C-terminal associated peptide (TCAP)-1 injections produce enduring changes in behavioral responses to corticotropin-releasing factor (CRF) in rat models of anxiety. | Tan LA et al. | β | 2008 | β |
| Synaptic physiology of central CRH system. | Gallagher JP et al. | β | 2008 | β |
| The neurocircuitry of addiction: an overview. | Feltenstein MW et al. | β | 2008 | β |
| Time dependent alterations on tyrosine hydroxylase, opioid and cannabinoid CB1 receptor gene expressions after acute ethanol administration in the rat brain. | Oliva JM et al. | β | 2008 | β |
| Age, sex and early environment contribute to individual differences in nicotine/acetaldehyde-induced behavioral and endocrine responses in rats. | Park MK et al. | β | 2007 | β |
| Biotechnology and the treatment of addictive disorders: new opportunities. | Elkashef A et al. | β | 2007 | β |
| Decreases in dietary preference produce increased emotionality and risk for dietary relapse. | Teegarden SL et al. | β | 2007 | β |
| Extreme chipping: addiction to a high-fat diet? | Carlezon WA et al. | β | 2007 | β |
| Intense sweetness surpasses cocaine reward. | Lenoir M et al. | β | 2007 | β |
| Stress and disease: is being female a predisposing factor? | Becker JB et al. | β | 2007 | β |
| The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats. | Der-Avakian A et al. | β | 2007 | β |
| The effects of a single session of inescapable tailshock on the subsequent locomotor response to brief footshock and cocaine administration in rats. | Der-Avakian A et al. | β | 2007 | β |
| The psychological science of addiction. | Gifford E et al. | β | 2007 | β |
| Drug addiction: the neurobiology of disrupted self-control. | Baler RD et al. | β | 2006 | β |
| Maternal smoking, drinking or cannabis use during pregnancy and neurobehavioral and cognitive functioning in human offspring. | Huizink AC et al. | β | 2006 | β |
| Morphine conditioned place preference depends on glucocorticoid receptors in both hippocampus and nucleus accumbens. | Dong Z et al. | β | 2006 | β |
| Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application. | Millan MJ | β | 2006 | β |
| Regulation of synaptic transmission by CRF receptors. | Orozco-Cabal L et al. | β | 2006 | β |
| Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system. | McLaughlin JP et al. | β | 2006 | β |
| Alternative pathways for catecholamine action in oral motor control. | Mascaro MB et al. | β | 2005 | β |
| Drugs and alcohol: treating and preventing abuse, addiction and their medical consequences. | Volkow ND et al. | β | 2005 | β |
| Is there a case for extended interventions for alcohol and drug use disorders? | McKay JR | β | 2005 | β |
| Norepinephrine transporter immunoblotting and radioligand binding in cocaine abusers. | Mash DC et al. | β | 2005 | β |
| Role of withdrawal in reinstatement of morphine-conditioned place preference. | Lu L et al. | β | 2005 | β |
| Stress and arousal: the corticotrophin-releasing factor/hypocretin circuitry. | Winsky-Sommerer R et al. | β | 2005 | β |
| The corticotropin-releasing factor (CRF)-system and monoaminergic afferents in the central amygdala: investigations in different mouse strains and comparison with the rat. | Asan E et al. | β | 2005 | β |
| The corticotropin-releasing factor receptor: a novel target for the treatment of depression and anxiety-related disorders. | Grigoriadis DE | β | 2005 | β |
| The impact of emotional stress early in life on adult voluntary ethanol intake-results of maternal separation in rats. | Roman E et al. | β | 2005 | β |
| The role of corticotropin-releasing factor-like peptides in cannabis, nicotine, and alcohol dependence. | Bruijnzeel AW et al. | β | 2005 | β |
| The "ups and downs" of signaling cascades in addiction. | Ron D et al. | β | 2005 | β |
| Time course of opioid and cannabinoid gene transcription alterations induced by repeated administration with fluoxetine in the rat brain. | Oliva JM et al. | β | 2005 | β |
| Corticotropin-releasing factor in brain: a role in activation, arousal, and affect regulation. | Heinrichs SC et al. | β | 2004 | β |
| Corticotropin-releasing hormone (CRH) mRNA expression in rat central amygdala in cannabinoid tolerance and withdrawal: evidence for an allostatic shift? | Caberlotto L et al. | β | 2004 | β |
| Drug addiction: the neurobiology of behaviour gone awry. | Volkow ND et al. | β | 2004 | β |
| Effects of a chromogranin-derived peptide (CgA 47-66) in the writhing nociceptive response induced by acetic acid in rats. | Ghia JE et al. | β | 2004 | β |
| Glutamate N-methyl-D-aspartate and dopamine receptors have contrasting effects on the limbic versus the somatosensory cortex with respect to amphetamine-induced neurodegeneration. | Bowyer JF et al. | β | 2004 | β |
| Immune cell activity during the initial stages of withdrawal from chronic exposure to cocaine or morphine. | Avila AH et al. | β | 2004 | β |
| Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activation. | Valdez GR et al. | β | 2004 | β |
| Neurobiological mechanisms in addictive and psychiatric disorders. | Bruijnzeel AW et al. | β | 2004 | β |
| New tools to monitor stress using non-invasive PET imaging. | Eckelman WC et al. | β | 2004 | β |
| The addicted human brain viewed in the light of imaging studies: brain circuits and treatment strategies. | Volkow ND et al. | β | 2004 | β |
| The reality of comorbidity: depression and drug abuse. | Volkow ND | β | 2004 | β |
| Antagonists of the corticotropin releasing factor receptor. | Saunders J et al. | β | 2003 | β |
| Corticoliberin protects neurons from the negative influences of "dysfunctins" in living olfactory cortex slices. | Shalyapina VG et al. | β | 2003 | β |
| Corticotropin-releasing factor testing reveals a dose-dependent difference in methadone maintained vs control subjects. | Schluger JH et al. | β | 2003 | β |
| CSF CRH in abstinent cocaine-dependent patients. | Roy A et al. | β | 2003 | β |
| Effects of corticotropin-releasing factor on plasticity of optically recorded neuronal activity in the substantia gelatinosa of rat spinal cord slices. | Ikeda H et al. | β | 2003 | β |
| Interrelations between monoaminergic afferents and corticotropin-releasing factor-immunoreactive neurons in the rat central amygdaloid nucleus: ultrastructural evidence for dopaminergic control of amygdaloid stress systems. | Eliava M et al. | β | 2003 | β |
| Morphine and cocaine influence on CRF biosynthesis in the rat central nucleus of amygdala. | Maj M et al. | β | 2003 | β |
| Nitrous oxide-induced c-Fos expression in the rat brain. | Kaiyala KJ et al. | β | 2003 | β |
| The reinstatement model of drug relapse: history, methodology and major findings. | Shaham Y et al. | β | 2003 | β |
| Independent alcohol and tobacco effects on stress axis function. | Anthenelli RM et al. | β | 2002 | β |
| Reactivation of cocaine conditioned place preference induced by stress is reversed by cholecystokinin-B receptors antagonist in rats. | Lu L et al. | β | 2002 | β |
| Regional and cellular mapping of cAMP response element-mediated transcription during naltrexone-precipitated morphine withdrawal. | Shaw-Lutchman TZ et al. | β | 2002 | β |
| Strain differences in urocortin expression in the Edinger-Westphal nucleus and its relation to alcohol-induced hypothermia. | Bachtell RK et al. | β | 2002 | β |
| Stress activation of glutamate neurotransmission in the prefrontal cortex: implications for dopamine-associated psychiatric disorders. | Moghaddam B | β | 2002 | β |
| Stress and cocaine addiction. | Goeders NE | β | 2002 | β |
| The orphanin FQ/nociceptin knockout mouse: a behavioral model for stress responses. | Reinscheid RK et al. | β | 2002 | β |
| Cloning, expression, and regulation of a glucocorticoid-induced receptor in rat brain: effect of repetitive amphetamine. | Wang D et al. | β | 2001 | β |
| Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors. | Weiss F et al. | β | 2001 | β |
| Finding paradigms for the future of alcoholism research: an interdisciplinary perspective. | Meyer RE | β | 2001 | β |
| Role of CRF(1) and CRF(2) receptors in fear and anxiety. | Takahashi LK | β | 2001 | β |
| Stress-induced relapse to drug seeking in the rat: role of the bed nucleus of the stria terminalis and amygdala. | Erb S et al. | β | 2001 | β |