Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts.
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- Authors
- Schumann, Gunter; Rujescu, Dan; Kissling, Christian; Soyka, Michael; Dahmen, Norbert; Preuss, Ullrich W; Wieman, Stefan; Depner, Martin; Wellek, Stefan; Lascorz, JesΓΊs; Bondy, Brigitta; Giegling, Ina; Anghelescu, Ion; Cowen, Michael S; Poustka, Annemarie; Spanagel, Rainer; Mann, Karl; Henn, Fritz A; Szegedi, Armin
- Year
- 2003
- Journal
- Biological psychiatry
- PMID
- 14675807
- DOI
- 10.1016/s0006-3223(03)00635-8
BACKGROUND: Decreased sensitivity to and increased tolerance for the effects of alcohol is a phenotype, which was shown to be associated with an increased risk for alcoholism in humans and was observed in protein tyrosine kinase (PTK) fyn knockout mice. METHODS: We performed an association study of genetic variations of PTK fyn in 430 alcohol-dependent patients and 365 unrelated control subjects from two independent samples. RESULTS: In a combined analysis, we found an association of alcohol dependence with the single nucleotide polymorphism (SNP) T137346C in the 5' untranslated region (UTR) of the gene. A relevant association could be excluded for the remaining two informative SNPs. Selection by phenotype showed that a high number of withdrawal symptoms, high amount of alcohol intake, and high maximum number of drinks compared with unrelated control subjects was associated with the SNP in the 5'-UTR region but not with the remaining SNPs. CONCLUSIONS: Our results indicate a possible association of alcohol dependence with a genotype of the SNP T137346C of the PTK fyn, with C being the risk allele.
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| Title | Year | PMID |
|---|---|---|
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | 2018 | 29623680 |
| Protein kinases and addiction. | 2008 | 18991950 |
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