Nicotine addiction and nicotinic receptors: lessons from genetically modified mice.
paper
Cited
Public
Unavailable
- Authors
- Changeux, Jean-Pierre
- Year
- 2010
- Journal
- Nature reviews. Neuroscience
- PMID
- 20485364
- DOI
- 10.1038/nrn2849
The past decades have seen a revolution in our understanding of brain diseases and in particular of drug addiction. This has been largely due to the identification of neurotransmitter receptors and the development of animal models, which together have enabled the investigation of brain functions from the molecular to the cognitive level. Tobacco smoking, the principal - yet avoidable - cause of lung cancer is associated with nicotine addiction. Recent studies in mice involving deletion and replacement of nicotinic acetylcholine receptor subunits have begun to identify the molecular mechanisms underlying nicotine addiction and might offer new therapeutic strategies to treat this addiction.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
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| Nicotine recruits glutamate receptors to postsynaptic sites. | Duan JJ et al. | — | 2015 | → |
| Nicotinic, glutamatergic and dopaminergic synaptic transmission and plasticity in the mesocorticolimbic system: focus on nicotine effects. | Pistillo F et al. | — | 2015 | → |
| Nicotinic receptor subtype-selective circuit patterns in the subthalamic nucleus. | Xiao C et al. | — | 2015 | → |
| Noribogaine reduces nicotine self-administration in rats. | Chang Q et al. | — | 2015 | → |
| Orthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking Cessation. | Mohamed TS et al. | — | 2015 | → |
| Repeated nicotine exposure in adolescent rats: Reduction of medial habenular activity and augmentation of nicotine preference. | Lee H et al. | — | 2015 | → |
| Role of α4- and α6-containing nicotinic receptors in the acquisition and maintenance of nicotine self-administration. | Madsen HB et al. | — | 2015 | → |
| Smoking during pregnancy affects foetal brain development. | Ekblad M et al. | — | 2015 | → |
| Structure of neuronal nicotinic receptors. | Fasoli F et al. | — | 2015 | → |
| The desensitization gate of inhibitory Cys-loop receptors. | Gielen M et al. | — | 2015 | → |
| The habenulo-interpeduncular pathway in nicotine aversion and withdrawal. | Antolin-Fontes B et al. | — | 2015 | → |
| The multiple roles of the α7 nicotinic acetylcholine receptor in modulating glutamatergic systems in the normal and diseased nervous system. | Koukouli F et al. | — | 2015 | → |
| The nicotine metabolite, cotinine, alters the assembly and trafficking of a subset of nicotinic acetylcholine receptors. | Fox AM et al. | — | 2015 | → |
| Varenicline enhances dopamine release facilitation more than nicotine after long-term nicotine treatment and withdrawal. | Perez XA et al. | — | 2015 | → |
| α2-Null mutant mice have altered levels of neuronal activity in restricted midbrain and limbic brain regions during nicotine withdrawal as demonstrated by cfos expression. | Upton M et al. | — | 2015 | → |
| Administration of the nicotinic acetylcholine receptor agonists ABT-089 and ABT-107 attenuates the reinstatement of nicotine-seeking behavior in rats. | Lee AM et al. | — | 2014 | → |
| Altered neurochemical levels in the rat brain following chronic nicotine treatment. | Falasca S et al. | — | 2014 | → |
| Basolateral amygdala CB1 cannabinoid receptors mediate nicotine-induced place preference. | Hashemizadeh S et al. | — | 2014 | → |
| Bupropion-induced inhibition of α7 nicotinic acetylcholine receptors expressed in heterologous cells and neurons from dorsal raphe nucleus and hippocampus. | Vázquez-Gómez E et al. | — | 2014 | → |
| Chrna5 genotype determines the long-lasting effects of developmental in vivo nicotine exposure on prefrontal attention circuitry. | Bailey CD et al. | — | 2014 | → |
| Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and reinstatement of nicotine seeking in rats. | Kimmey BA et al. | — | 2014 | → |
| Expression of mu opioid receptor in dorsal diencephalic conduction system: new insights for the medial habenula. | Gardon O et al. | — | 2014 | → |
| Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior. | Haller G et al. | — | 2014 | → |
| Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice. | Harenza JL et al. | — | 2014 | → |
| Illuminating the role of cholinergic signaling in circuits of attention and emotionally salient behaviors. | Luchicchi A et al. | — | 2014 | → |
| Imaging of α7 nicotinic acetylcholine receptors in brain and cerebral vasculature of juvenile pigs with [(18)F]NS14490. | Rötering S et al. | — | 2014 | → |
| Involvement of neuronal β2 subunit-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal: implications for pharmacotherapies. | Simmons SJ et al. | — | 2014 | → |
| Joint association of nicotinic acetylcholine receptor variants with abdominal obesity in American Indians: the Strong Heart Family Study. | Zhu Y et al. | — | 2014 | → |
| Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway. | Nordman JC et al. | — | 2014 | → |
| Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine. | Wang L et al. | — | 2014 | → |
| Molecules and circuits involved in nicotine addiction: The many faces of smoking. | Picciotto MR et al. | — | 2014 | → |
| Nicotine alters the proteome of two human pancreatic duct cell lines. | Paulo JA | — | 2014 | → |
| Nicotine consumption is regulated by a human polymorphism in dopamine neurons. | Morel C et al. | — | 2014 | → |
| Nicotinic receptor modulation to treat alcohol and drug dependence. | Rahman S et al. | — | 2014 | → |
| Nicotinic receptors regulate the dynamic range of dopamine release in vivo. | Koranda JL et al. | — | 2014 | → |
| Optimizing treatments for nicotine dependence by increasing cognitive performance during withdrawal. | Ashare RL et al. | — | 2014 | → |
| Optogenetic studies of nicotinic contributions to cholinergic signaling in the central nervous system. | Jiang L et al. | — | 2014 | → |
| Physiological effects of cigarette smoking in the limbic system revealed by 3 tesla magnetic resonance spectroscopy. | Mennecke A et al. | — | 2014 | → |
| Prenatal glucocorticoids and maternal smoking during pregnancy independently program adult nicotine dependence in daughters: a 40-year prospective study. | Stroud LR et al. | — | 2014 | → |
| Protein dynamics and the allosteric transitions of pentameric receptor channels. | Changeux JP | — | 2014 | → |
| Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors. | Yu LF et al. | — | 2014 | → |
| Re-defininG AddiC(CH3)Tion: genomics and epigenomics on substance use disorders. | Rutter JL et al. | — | 2014 | → |
| Role of nicotinic acetylcholine receptors in regulating dopamine neuron activity. | Faure P et al. | — | 2014 | → |
| Seven-membered azabridged neonicotinoids: synthesis, crystal structure, insecticidal assay, and molecular docking studies. | Xu R et al. | — | 2014 | → |
| Smoking cessation. | Rennard SI et al. | — | 2014 | → |
| Structural insights into the specific recognition of N-heterocycle biodenitrogenation-derived substrates by microbial amide hydrolases. | Wu G et al. | — | 2014 | → |
| Targeting the interaction between fatty acid ethanolamides and nicotinic receptors: therapeutic perspectives. | Melis M et al. | — | 2014 | → |
| The role of alpha-7 nicotinic receptors in food intake behaviors. | McFadden KL et al. | — | 2014 | → |
| The α4 nicotinic receptor promotes CD4+ T-cell proliferation and a helper T-cell immune response. | Nordman JC et al. | — | 2014 | → |
| Use of rodents as models of human diseases. | Vandamme TF | — | 2014 | → |
| Varenicline and cytisine diminish the dysphoric-like state associated with spontaneous nicotine withdrawal in rats. | Igari M et al. | — | 2014 | → |
| Activation of α7-containing nicotinic receptors on astrocytes triggers AMPA receptor recruitment to glutamatergic synapses. | Wang X et al. | — | 2013 | → |
| A novel highly selective 5-HT6 receptor antagonist attenuates ethanol and nicotine seeking but does not affect inhibitory response control in Wistar rats. | de Bruin NMWJ et al. | — | 2013 | → |
| A tale of two receptors: Dual roles for ionotropic acetylcholine receptors in regulating motor neuron excitation and inhibition. | Philbrook A et al. | — | 2013 | → |
| Behavioral and molecular analysis of nicotine-conditioned place preference in zebrafish. | Kedikian X et al. | — | 2013 | → |
| CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 nAChR with improved selectivity for tobacco smoking cessation. | Sala M et al. | — | 2013 | → |
| ChAT-ChR2-EYFP mice have enhanced motor endurance but show deficits in attention and several additional cognitive domains. | Kolisnyk B et al. | — | 2013 | → |
| Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement. | Tolu S et al. | — | 2013 | → |
| Cross-species analysis of nicotine-induced proteomic alterations in pancreatic cells. | Paulo JA et al. | — | 2013 | → |
| Effects of chronic low- and high-dose nicotine on cognitive flexibility in C57BL/6J mice. | Ortega LA et al. | — | 2013 | → |
| Endogenous cholinergic inputs and local circuit mechanisms govern the phasic mesolimbic dopamine response to nicotine. | Graupner M et al. | — | 2013 | → |
| Evaluating the role of the alpha-7 nicotinic acetylcholine receptor in the pathophysiology and treatment of schizophrenia. | Young JW et al. | — | 2013 | → |
| High-affinity nicotinic acetylcholine receptor expression and trafficking abnormalities in psychiatric illness. | Lewis AS et al. | — | 2013 | → |
| High density of nicotinic receptors in the cingulo-insular network. | Picard F et al. | — | 2013 | → |
| Intermittent nicotine exposure upregulates nAChRs in VTA dopamine neurons and sensitises locomotor responding to the drug. | Baker LK et al. | — | 2013 | → |
| Joint associations of 61 genetic variants in the nicotinic acetylcholine receptor genes with subclinical atherosclerosis in American Indians: a gene-family analysis. | Yang J et al. | — | 2013 | → |
| Long-term nicotine treatment down-regulates α6β2* nicotinic receptor expression and function in nucleus accumbens. | Perez XA et al. | — | 2013 | → |
| Mecamylamine-precipitated nicotine withdrawal syndrome and its prevention with baclofen: an autoradiographic study of α4β2 nicotinic acetylcholine receptors in mice. | Varani AP et al. | — | 2013 | → |
| Multiple CNS nicotinic receptors mediate L-dopa-induced dyskinesias: studies with parkinsonian nicotinic receptor knockout mice. | Quik M et al. | — | 2013 | → |
| nAChR-induced octopamine release mediates the effect of nicotine on a startle response in Drosophila melanogaster. | Fuenzalida-Uribe N et al. | — | 2013 | → |
| Nicotine-induced structural plasticity in mesencephalic dopaminergic neurons is mediated by dopamine D3 receptors and Akt-mTORC1 signaling. | Collo G et al. | — | 2013 | → |
| Nicotinic acetylcholine receptors controlling attention: behavior, circuits and sensitivity to disruption by nicotine. | Poorthuis RB et al. | — | 2013 | → |
| Not so Cool? Menthol's discovered actions on the nicotinic receptor and its implications for nicotine addiction. | Kabbani N | — | 2013 | → |
| Reexposure to nicotine during withdrawal increases the pacemaking activity of cholinergic habenular neurons. | Görlich A et al. | — | 2013 | → |
| Regulation of cholinergic activity by the vesicular acetylcholine transporter. | Prado VF et al. | — | 2013 | → |
| The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice. | Ignatowska-Jankowska BM et al. | — | 2013 | → |
| The concept of allosteric interaction and its consequences for the chemistry of the brain. | Changeux JP | — | 2013 | → |
| The "stop" and "go" of nicotine dependence: role of GABA and glutamate. | D'Souza MS et al. | — | 2013 | → |
| The β2 nicotinic acetylcholine receptor subunit differentially influences ethanol behavioral effects in the mouse. | Dawson A et al. | — | 2013 | → |
| Advancing addiction treatment: what can we learn from animal studies? | Wu PH et al. | — | 2012 | → |
| A gene-family analysis of 61 genetic variants in the nicotinic acetylcholine receptor genes for insulin resistance and type 2 diabetes in American Indians. | Yang J et al. | — | 2012 | → |
| Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice. | Besson M et al. | — | 2012 | → |
| An interaction between α7 nicotinic receptors and a G-protein pathway complex regulates neurite growth in neural cells. | Nordman JC et al. | — | 2012 | → |
| A single administration of low-dose varenicline saturates α4β2* nicotinic acetylcholine receptors in the human brain. | Lotfipour S et al. | — | 2012 | → |
| Association between adverse life events and addictive behaviors among male and female adolescents. | Lee GP et al. | — | 2012 | → |
| Chronic nicotine administration impairs activation of cyclic AMP-response element binding protein and survival of newborn cells in the dentate gyrus. | Wei Z et al. | — | 2012 | → |
| Cocaine and nicotine research illustrates a range of hypocretin mechanisms in addiction. | Baimel C et al. | — | 2012 | → |
| Combined α7 nicotinic acetylcholine receptor agonism and partial serotonin transporter inhibition produce antidepressant-like effects in the mouse forced swim and tail suspension tests: a comparison of SSR180711 and PNU-282987. | Andreasen JT et al. | — | 2012 | → |
| Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II. | Yu LF et al. | — | 2012 | → |
| Do initial responses to drugs predict future use or abuse? | de Wit H et al. | — | 2012 | → |
| Dopamine D1 receptor antagonism impairs extinction of cocaine-cue memories. | Fricks-Gleason AN et al. | — | 2012 | → |
| Down-regulation of Decapping Protein 2 mediates chronic nicotine exposure-induced locomotor hyperactivity in Drosophila. | Ren J et al. | — | 2012 | → |
| Enhanced attenuation of nicotine discrimination in rats by combining nicotine-specific antibodies with a nicotinic receptor antagonist. | LeSage MG et al. | — | 2012 | → |
| Galantamine, an acetylcholinesterase inhibitor and positive allosteric modulator of nicotinic acetylcholine receptors, attenuates nicotine taking and seeking in rats. | Hopkins TJ et al. | — | 2012 | → |
| Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template. | Grimster NP et al. | — | 2012 | → |
| Glutamatergic synapse formation is promoted by α7-containing nicotinic acetylcholine receptors. | Lozada AF et al. | — | 2012 | → |
| Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity. | Yu LF et al. | — | 2012 | → |
| Induction of dendritic spines by β2-containing nicotinic receptors. | Lozada AF et al. | — | 2012 | → |
| Insights into the neurobiology of the nicotinic cholinergic system and nicotine addiction from mice expressing nicotinic receptors harboring gain-of-function mutations. | Drenan RM et al. | — | 2012 | → |
| Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons. | Dobelis P et al. | — | 2012 | → |
| Long-term nicotine exposure depresses dopamine release in nonhuman primate nucleus accumbens. | Perez XA et al. | — | 2012 | → |
| Mice lacking the β4 subunit of the nicotinic acetylcholine receptor show memory deficits, altered anxiety- and depression-like behavior, and diminished nicotine-induced analgesia. | Semenova S et al. | — | 2012 | → |
| Mitochondria express α7 nicotinic acetylcholine receptors to regulate Ca2+ accumulation and cytochrome c release: study on isolated mitochondria. | Gergalova G et al. | — | 2012 | → |
| Modeling human neurodegenerative diseases in transgenic systems. | Gama Sosa MA et al. | — | 2012 | → |
| Nicotine reduces antipsychotic-induced orofacial dyskinesia in rats. | Bordia T et al. | — | 2012 | → |
| Overnight deprivation from smoking disrupts amygdala responses to fear. | Onur OA et al. | — | 2012 | → |
| Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes. | Gold AB et al. | — | 2012 | → |
| Prefrontal neuromodulation by nicotinic receptors for cognitive processes. | dos Santos Coura R et al. | — | 2012 | → |
| Recent advances in the genetic epidemiology and molecular genetics of substance use disorders. | Kendler KS et al. | — | 2012 | → |
| Reward sensitization: effects of repeated nicotine exposure and withdrawal in mice. | Hilario MR et al. | — | 2012 | → |
| Stress-induced activation of the dynorphin/κ-opioid receptor system in the amygdala potentiates nicotine conditioned place preference. | Smith JS et al. | — | 2012 | → |
| The natural course of nicotine dependence symptoms among adolescent smokers. | Zhan W et al. | — | 2012 | → |
| Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice. | Gallego X et al. | — | 2012 | → |
| Unraveling acetylcholine impact on human cortical plasticity. | Suppa A et al. | — | 2012 | → |
| Varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum. | Bordia T et al. | — | 2012 | → |
| Zebrafish: a model for the study of addiction genetics. | Klee EW et al. | — | 2012 | → |
| α4* Nicotinic acetylcholine receptors modulate experience-based cortical depression in the adult mouse somatosensory cortex. | Brown CE et al. | — | 2012 | → |
| Aversion to nicotine is regulated by the balanced activity of β4 and α5 nicotinic receptor subunits in the medial habenula. | Frahm S et al. | — | 2011 | → |
| CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression. | Krais AM et al. | — | 2011 | → |
| Cigarette smoking, cyclooxygenase-2 pathway and cancer. | Huang RY et al. | — | 2011 | → |
| Critical role of peripheral actions of intravenous nicotine in mediating its central effects. | Lenoir M et al. | — | 2011 | → |
| Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine. | Exley R et al. | — | 2011 | → |
| Emergent pharmacology of conscious experience: new perspectives in substance addiction. | Changeux JP et al. | — | 2011 | → |
| Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors. | Pucci L et al. | — | 2011 | → |
| Experimental and theoretical approaches to conscious processing. | Dehaene S et al. | — | 2011 | → |
| Fluctuations in central and peripheral temperatures induced by intravenous nicotine: central and peripheral contributions. | Tang JS et al. | — | 2011 | → |
| Genes and pathways co-associated with the exposure to multiple drugs of abuse, including alcohol, amphetamine/methamphetamine, cocaine, marijuana, morphine, and/or nicotine: a review of proteomics analyses. | Wang J et al. | — | 2011 | → |
| Habenula "cholinergic" neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes. | Ren J et al. | — | 2011 | → |
| Interaction of bupropion and zinc with neuronal nicotinic acetylcholine receptors. | García-Colunga J et al. | — | 2011 | → |
| Intravenous nicotine self-administration and cue-induced reinstatement in mice: effects of nicotine dose, rate of drug infusion and prior instrumental training. | Fowler CD et al. | — | 2011 | → |
| Nicotine and endogenous opioids: neurochemical and pharmacological evidence. | Hadjiconstantinou M et al. | — | 2011 | → |
| Prefrontal nicotinic receptors control novel social interaction between mice. | Avale ME et al. | — | 2011 | → |
| Prenatal nicotine increases matrix metalloproteinase 2 (MMP-2) expression in fetal guinea pig hearts. | Thompson LP et al. | — | 2011 | → |
| Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. | Witten IB et al. | — | 2011 | → |
| Recruitment of α7 nicotinic acetylcholine receptor to caveolin-1-enriched lipid rafts is required for nicotine-enhanced Escherichia coli K1 entry into brain endothelial cells. | Chi F et al. | — | 2011 | → |
| Regulation of the immediate-early genes arc and zif268 in a mouse operant model of cocaine seeking reinstatement. | Ziółkowska B et al. | — | 2011 | → |
| Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. | Wassenaar CA et al. | — | 2011 | → |
| Role of α6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders. | Quik M et al. | — | 2011 | → |
| Smoking related diseases: the central role of monoamine oxidase. | Rendu F et al. | — | 2011 | → |
| The 5-HT₆ serotonin receptor antagonist SB-271046 attenuates the development and expression of nicotine-induced locomotor sensitisation in Wistar rats. | de Bruin NM et al. | — | 2011 | → |
| The necessity of α4* nicotinic receptors in nicotine-driven behaviors: dissociation between reinforcing and motor effects of nicotine. | Cahir E et al. | — | 2011 | → |
| Zebrafish for the study of the biological effects of nicotine. | Klee EW et al. | — | 2011 | → |
| α6β2* and α4β2* nicotinic acetylcholine receptors as drug targets for Parkinson's disease. | Quik M et al. | — | 2011 | → |
| A caged nicotine with nanosecond range kinetics and visible light sensitivity. | Filevich O et al. | — | 2010 | → |
| Nicotinic receptor gene CHRNA4 interacts with processing load in attention. | Espeseth T et al. | — | 2010 | → |
| Varenicline for smoking cessation: efficacy, safety, and treatment recommendations. | Ebbert JO et al. | — | 2010 | → |