Problems of reporting genetic associations with complex outcomes.
paper
Cited
Public
Unavailable
- Authors
- Colhoun, Helen M; McKeigue, Paul M; Davey Smith, George
- Year
- 2003
- Journal
- Lancet (London, England)
- PMID
- 12642066
- DOI
- 10.1016/s0140-6736(03)12715-8
Inability to replicate many results has led to increasing scepticism about the value of simple association study designs for detection of genetic variants contributing to common complex traits. Much attention has been drawn to the problems that might, in theory, bedevil this approach, including confounding from population structure, misclassification of outcome, and allelic heterogeneity. Other researchers have argued that absence of replication may indicate true heterogeneity in gene-disease associations. We suggest that the most important factors underlying inability to replicate these associations are publication bias, failure to attribute results to chance, and inadequate sample sizes, problems that are all rectifiable. Without changes to present practice, we risk wastage of scientific effort and rejection of a potentially useful research strategy.
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| The C161T polymorphism in the peroxisome proliferator-activated receptor gamma gene (PPARΞ³) is associated with risk of coronary artery disease: a meta-analysis. | Wu Z et al. | β | 2013 | β |
| The power of meta-analysis in genome-wide association studies. | Panagiotou OA et al. | β | 2013 | β |
| The relationship between eight GWAS-identified single-nucleotide polymorphisms and primary breast cancer outcomes. | Bayraktar S et al. | β | 2013 | β |
| A genetic instrument for Mendelian randomization of fibrinogen. | Ken-Dror G et al. | β | 2012 | β |
| Association between MTHFR polymorphisms and orofacial clefts risk: a meta-analysis. | Luo YL et al. | β | 2012 | β |
| Association between the Pro12Ala polymorphism of PPAR-Ξ³ gene and the polycystic ovary syndrome: a meta-analysis of case-control studies. | Zhang H et al. | β | 2012 | β |
| Association between variations in coagulation system genes and carotid plaque. | Della-Morte D et al. | β | 2012 | β |
| Association of angiotensin-converting enzyme I/D polymorphism with heart failure: a meta-analysis. | Bai Y et al. | β | 2012 | β |
| Association study of CARD8 (p.C10X) and NLRP3 (p.Q705K) variants with rheumatoid arthritis in French and Tunisian populations. | Ben Hamad M et al. | β | 2012 | β |
| Calcium-sensing receptor gene polymorphisms in patients with calcium nephrolithiasis. | Vezzoli G et al. | β | 2012 | β |
| Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis. | TammimΓ€ki A et al. | β | 2012 | β |
| Clinical pharmacogenetic model to predict response of MTX monotherapy in patients with established rheumatoid arthritis after DMARD failure. | Fransen J et al. | β | 2012 | β |
| Clinical relevance of RET variants G691S, L769L, S836S and S904S to sporadic medullary thyroid cancer. | Machens A et al. | β | 2012 | β |
| Fetal and maternal candidate single nucleotide polymorphism associations with cerebral palsy: a case-control study. | O'Callaghan ME et al. | β | 2012 | β |
| Gender-specific role of the protein tyrosine phosphatase receptor type R gene in major depressive disorder. | Shi C et al. | β | 2012 | β |
| Genetic association studies in pre-eclampsia: systematic meta-analyses and field synopsis. | Staines-Urias E et al. | β | 2012 | β |
| Genetic contributions to intergroup responses: a cautionary perspective. | Ratner KG et al. | β | 2012 | β |
| Genetic polymorphisms in adipokine genes and the risk of obesity: a systematic review and meta-analysis. | Yu Z et al. | β | 2012 | β |
| Influence of common non-synonymous Toll-like receptor 4 polymorphisms on bronchopulmonary dysplasia and prematurity in human infants. | Lavoie PM et al. | β | 2012 | β |
| Innovations in Endosurgery-Journey into the Past of the Future: To Ride the SILS Bandwagon or Not? | Agarwal BB et al. | β | 2012 | β |
| Investigation of allelic heterogeneity of the CCK-A receptor gene in paranoid schizophrenia. | Zheng C et al. | β | 2012 | β |
| Lack of association between p.Ser167Asn variant of Parkin and Parkinson's disease: a meta-analysis of 15 studies involving 2,280 cases and 2,459 controls. | Zhang Y et al. | β | 2012 | β |
| Lack of Association of Vitamin D Receptor FokI (rs10735810) (C/T) and BsmI (rs1544410) (A/G) Genetic Variations with Polycystic Ovary Syndrome Risk: a Case-control Study from Iranian Azeri Turkish Women. | Bagheri M et al. | β | 2012 | β |
| Methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to cervical cancer and cervical intraepithelial neoplasia: a meta-analysis. | Luo YL et al. | β | 2012 | β |
| Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis. | Dervieux T et al. | β | 2012 | β |
| Prostate cancer risk is not altered by TP53AIP1 germline mutations in a German case-control series. | Luedeke M et al. | β | 2012 | β |
| Single nucleotide polymorphisms and outcome risk in unrelated mismatched hematopoietic stem cell transplantation: an exploration study. | Harkensee C et al. | β | 2012 | β |
| SLC6A4 gene variants and temporal lobe epilepsy susceptibility: a meta-analysis. | CΓ³rdoba M et al. | β | 2012 | β |
| The canid genome: behavioral geneticists' best friend? | Hall NJ et al. | β | 2012 | β |
| The genetics of Alzheimer's disease. | Barber RC | β | 2012 | β |
| The influence of five monoamine genes on trajectories of depressive symptoms across adolescence and young adulthood. | Adkins DE et al. | β | 2012 | β |
| Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease. | Relton CL et al. | β | 2012 | β |
| A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. | Duncan LE et al. | β | 2011 | β |
| Alzheimer's disease genetics: current knowledge and future challenges. | Hollingworth P et al. | β | 2011 | β |
| Association analysis of the LTA4H gene polymorphisms and pulmonary tuberculosis in 9115 subjects. | Curtis J et al. | β | 2011 | β |
| Association of COMT Val(108/158)Met genotype and cigarette smoking in pregnant women. | MunafΓ² MR et al. | β | 2011 | β |
| Candidate genes and risk for CP: a population-based study. | Wu YW et al. | β | 2011 | β |
| CD24 as a genetic modifier of disease progression in multiple sclerosis in Argentinean patients. | GonzΓ‘lez SJ et al. | β | 2011 | β |
| Combined effect of CYP1B1, COMT, GSTP1, and MnSOD genotypes and risk of postmenopausal breast cancer. | Cerne JZ et al. | β | 2011 | β |
| CYP2D6 inhibition and breast cancer recurrence in a population-based study in Denmark. | Lash TL et al. | β | 2011 | β |
| Effect of genome-wide simultaneous hypotheses tests on the discovery rate. | Eyheramendy S et al. | β | 2011 | β |
| Effect of paraoxonase-1 polymorphism on clinical outcomes in patients treated with clopidogrel after an acute myocardial infarction. | Simon T et al. | β | 2011 | β |
| Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1. | Sundqvist J et al. | β | 2011 | β |
| FTO gene polymorphisms and obesity risk: a meta-analysis. | Peng S et al. | β | 2011 | β |
| Gene associations - SNPs and function. | Ebers GC | β | 2011 | β |
| Gene-PUFA interactions and obesity risk. | Jourdan C et al. | β | 2011 | β |
| Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus. | Ramos PS et al. | β | 2011 | β |
| Genetics and calcium nephrolithiasis. | Vezzoli G et al. | β | 2011 | β |
| Genetics of dementia. | Paulson HL et al. | β | 2011 | β |
| Genetic variants and the risk for invasive mould disease in immunocompromised hematology patients. | van der Velden WJ et al. | β | 2011 | β |
| Haplotype analysis improved evidence for candidate genes for intramuscular fat percentage from a genome wide association study of cattle. | Barendse W | β | 2011 | β |
| IGF-1 gene polymorphisms in Polish families with high-grade myopia. | Rydzanicz M et al. | β | 2011 | β |
| Immunogenetics of hematopoietic stem cell transplantation: the contribution of microsatellite polymorphism studies. | Tiercy JM | β | 2011 | β |
| Impact of ATP-binding cassette, subfamily B, member 1 pharmacogenetics on tacrolimus-associated nephrotoxicity and dosage requirements in paediatric patients with liver transplant. | Hawwa AF et al. | β | 2011 | β |
| Impact of polymorphisms in the renin-angiotensin-aldosterone system on hypertrophic cardiomyopathy. | Orenes-PiΓ±ero E et al. | β | 2011 | β |
| Issues in genetic association studies: limitations of statistical analysis and biological plausibility. | Van der Velden WJ et al. | β | 2011 | β |
| Large scale association analysis identifies three susceptibility loci for coronary artery disease. | Saade S et al. | β | 2011 | β |
| Lipoprotein-associated phospholipase A2 gene V279F polymorphisms and coronary heart disease: a meta-analysis. | Zheng GH et al. | β | 2011 | β |
| Mendelian randomization: the use of genes in instrumental variable analyses. | von Hinke Kessler Scholder S et al. | β | 2011 | β |
| No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis. | Hashimoto R et al. | β | 2011 | β |
| Pharmacogenetics of the lipodystrophy syndrome associated with HIV infection and combination antiretroviral therapy. | Vidal F et al. | β | 2011 | β |
| Prothrombotic gene variants and mortality after cerebral ischemia of arterial origin. | Pruissen DM et al. | β | 2011 | β |
| Random allocation in observational data: how small but robust effects could facilitate hypothesis-free causal inference. | Davey Smith G | β | 2011 | β |
| Signal transducer and activator of transcription 4 gene polymorphisms associated with rheumatoid arthritis in Northwestern Chinese Han population. | Liang YL et al. | β | 2011 | β |
| Significance testing as perverse probabilistic reasoning. | Westover MB et al. | β | 2011 | β |
| Ten years later, still "gene in a haystack?". | Norris PR et al. | β | 2011 | β |
| The false-positive to false-negative ratio in epidemiologic studies. | Ioannidis JP et al. | β | 2011 | β |
| The genetics of pre-eclampsia and other hypertensive disorders of pregnancy. | Williams PJ et al. | β | 2011 | β |
| Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour. | Peden JF et al. | β | 2011 | β |
| Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health. | Davey Smith G | β | 2011 | β |
| +294T/C polymorphism in the PPAR-delta gene is associated with risk of coronary artery disease in normolipidemic Tunisians. | Jguirim-Souissi I et al. | β | 2010 | β |
| A1166C genetic variation of the angiotensin II type I receptor gene and susceptibility to coronary heart disease: collaborative of 53 studies with 20,435 cases and 23,674 controls. | Xu M et al. | β | 2010 | β |
| Absence of consistent association between human leukocyte antigen-I and -II alleles and human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis risk in an HTLV-1 French Afro-Caribbean population. | Deschamps R et al. | β | 2010 | β |
| Angiotensin-converting enzyme insertion/deletion gene polymorphism in a Tunisian healthy and acute myocardial infarction population. | Mehri S et al. | β | 2010 | β |
| An update on the genetics of atopic dermatitis: scratching the surface in 2009. | Barnes KC | β | 2010 | β |
| Are genetic variants of COMT associated with addiction? | TammimΓ€ki AE et al. | β | 2010 | β |
| Aspects of observing and claiming allele flips in association studies. | Clarke GM et al. | β | 2010 | β |
| Association between interleukin-6 gene promoter -572C/G polymorphism and the risk of sporadic Alzheimer's disease. | He MX et al. | β | 2010 | β |
| Association between lymphotoxin-alpha (tumor necrosis factor-beta) intron polymorphism and predisposition to severe sepsis is modified by gender and age. | Watanabe E et al. | β | 2010 | β |
| Association between the heme oxygenase-1 promoter polymorphism and renal transplantation outcome in Greece. | Katana E et al. | β | 2010 | β |
| Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease. | Gu LQ et al. | β | 2010 | β |
| Dyslipidemia in HIV-infected individuals: from pharmacogenetics to pharmacogenomics. | Tarr PE et al. | β | 2010 | β |
| Effect of including environmental data in investigations of gene-disease associations in the presence of qualitative interactions. | Williamson E et al. | β | 2010 | β |
| Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx). | Metry KJ et al. | β | 2010 | β |
| Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study. | Brophy K et al. | β | 2010 | β |
| FADS2 polymorphisms modify the effect of breastfeeding on child IQ. | Steer CD et al. | β | 2010 | β |
| Functional polymorphisms and methotrexate treatment outcome in recent-onset rheumatoid arthritis. | Kooloos WM et al. | β | 2010 | β |
| Genetic associations in Italian primary sclerosing cholangitis: heterogeneity across Europe defines a critical role for HLA-C. | Hov JR et al. | β | 2010 | β |
| Genetic, personality, and environmental predictors of drug use in adolescents. | Conner BT et al. | β | 2010 | β |
| Genetic predisposition to adverse drug reactions in the intensive care unit. | Empey PE | β | 2010 | β |
| Genetics of hypospadias: are single-nucleotide polymorphisms in SRD5A2, ESR1, ESR2, and ATF3 really associated with the malformation? | van der Zanden LF et al. | β | 2010 | β |
| Genetic variants in the RELN gene are associated with otosclerosis in multiple European populations. | Schrauwen I et al. | β | 2010 | β |
| Genome-wide association studies in nephrology research. | KΓΆttgen A | β | 2010 | β |
| Heritability of body weight: moving beyond genetics. | Russo P et al. | β | 2010 | β |
| Host genetics and outcome in meningococcal disease: a systematic review and meta-analysis. | Brouwer MC et al. | β | 2010 | β |
| Mendelian randomization as applied to coronary heart disease, including recent advances incorporating new technology. | Lewis SJ | β | 2010 | β |
| Meta-analysis of genetic association studies: magic tool or dangerous black box? | Minelli C et al. | β | 2010 | β |
| MTHFR polymorphisms in relation to ovarian cancer risk. | Terry KL et al. | β | 2010 | β |
| Multiple sclerosis: a practical overview for clinicians. | Rejdak K et al. | β | 2010 | β |
| Pharmacogenetics of tomorrow: the 1 + 1 = 3 principle. | Pander J et al. | β | 2010 | β |
| Response to methylphenidate is not influenced by DAT1 polymorphisms in a sample of Brazilian adult patients with ADHD. | Contini V et al. | β | 2010 | β |
| Selection of extreme phenotypes: the role of clinical observation in translational research. | PΓ©rez-Gracia JL et al. | β | 2010 | β |
| The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis. | Gouda HN et al. | β | 2010 | β |
| The AZFc region of the Y chromosome: at the crossroads between genetic diversity and male infertility. | Navarro-Costa P et al. | β | 2010 | β |
| The combination of ERCC1 and XRCC1 gene polymorphisms better predicts clinical outcome to oxaliplatin-based chemotherapy in metastatic colorectal cancer. | Liang J et al. | β | 2010 | β |
| The complement component 5 gene and age-related macular degeneration. | Baas DC et al. | β | 2010 | β |
| The etiology of otosclerosis: a combination of genes and environment. | Schrauwen I et al. | β | 2010 | β |
| Use of a modeling framework to evaluate the effect of a modifier gene (MBL2) on variation in cystic fibrosis. | McDougal KE et al. | β | 2010 | β |
| Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients. | Kristensen MH et al. | β | 2010 | β |
| Acquired somatic mutations in the microsatellite DNA, in children with bronchial asthma. | Thomou C et al. | β | 2009 | β |
| Additive effect of LRP8/APOER2 R952Q variant to APOE epsilon2/epsilon3/epsilon4 genotype in modulating apolipoprotein E concentration and the risk of myocardial infarction: a case-control study. | Martinelli N et al. | β | 2009 | β |
| A genome-wide analysis identifies genetic variants in the RELN gene associated with otosclerosis. | Schrauwen I et al. | β | 2009 | β |
| Age-specific effects of estrogen receptors' polymorphisms on the bone traits in healthy fertile women: the BONTURNO study. | Massart F et al. | β | 2009 | β |
| ApoE epsilon4 is not associated with posictal confusion in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. | Kauffman MA et al. | β | 2009 | β |
| Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study. | Song H et al. | β | 2009 | β |
| Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease. | Zhu G et al. | β | 2009 | β |
| Autoimmunity risk alleles in costimulation pathways. | Maier LM et al. | β | 2009 | β |
| Bayes factors for genome-wide association studies: comparison with P-values. | Wakefield J | β | 2009 | β |
| Bias in the research literature and conflict of interest: an issue for publishers, editors, reviewers and authors, and it is not just about the money. | Young SN | β | 2009 | β |
| Brain-derived neurotrophic factor gene val66met polymorphism and executive functioning in patients with bipolar disorder. | Tramontina JF et al. | β | 2009 | β |
| Cardiovascular nursing on human genomics: what do cardiovascular nurses need to know about congestive heart failure? | Frazier L et al. | β | 2009 | β |
| Chronic obstructive pulmonary disease: towards pharmacogenetics. | Wood AM et al. | β | 2009 | β |
| Clinical relevance of the interleukin 10 promoter polymorphisms in Chinese Han patients with major trauma: genetic association studies. | Zeng L et al. | β | 2009 | β |
| Coding variant Met72Thr in the PEDF gene and risk of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. | Bessho H et al. | β | 2009 | β |
| Comment to Tumour necrosis factor alpha gene -376 polymorphism in Hungarian patients with primary progressive multiple sclerosis. | Kauffman MA et al. | β | 2009 | β |
| Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations. | Bendaly J et al. | β | 2009 | β |
| Distributions of glucocorticoid receptor gene polymorphisms in a Chinese Han population and associations with outcome after major trauma. | Duan ZX et al. | β | 2009 | β |
| DNMBP is genetically associated with Alzheimer dementia in the Belgian population. | Bettens K et al. | β | 2009 | β |
| Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complex. | Chao MJ et al. | β | 2009 | β |
| European Charcot Foundation Lecture: the natural history of multiple sclerosis and gender. | Sadovnick AD | β | 2009 | β |
| Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. | Kweekel DM et al. | β | 2009 | β |
| Fine mapping linkage analysis identifies a novel susceptibility locus for myopia on chromosome 2q37 adjacent to but not overlapping MYP12. | SchΓ€che M et al. | β | 2009 | β |
| Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. | Holmes MV et al. | β | 2009 | β |
| Functional SNPs in the SCGB3A2 promoter are associated with susceptibility to Graves' disease. | Song HD et al. | β | 2009 | β |
| Gene by environment interaction in asthma. | London SJ et al. | β | 2009 | β |
| Genetic association between -93A/G polymorphism in the Fyn kinase gene and alcohol dependence in Spanish men. | Pastor IJ et al. | β | 2009 | β |
| Genetic association studies of methamphetamine use disorders: A systematic review and synthesis. | Bousman CA et al. | β | 2009 | β |
| Genetic polymorphisms of the angiotensin II type 1 receptor gene and diastolic heart failure. | Wu CK et al. | β | 2009 | β |
| Genetics of otosclerosis. | Thys M et al. | β | 2009 | β |
| Gene X environment interactions at the serotonin transporter locus. | MunafΓ² MR et al. | β | 2009 | β |
| Genome paths: a way to personalized and predictive medicine. | Baranov VS | β | 2009 | β |
| Genome-wide association studies reach hepatology. | Karlsen TH | β | 2009 | β |
| Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis. | Brouwer MC et al. | β | 2009 | β |
| Human genetics and resistance to parasitic infection. | Shaw MA et al. | β | 2009 | β |
| Human V-ATPase gene can protect or predispose the host to pulmonary tuberculosis. | Capparelli R et al. | β | 2009 | β |
| Identifying susceptibility genes of IgA nephropathy: research in progress. | Barua M et al. | β | 2009 | β |
| INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study. | Talbert ME et al. | β | 2009 | β |
| Meta-analysis of genetic association studies: methodologies, between-study heterogeneity and winner's curse. | Nakaoka H et al. | β | 2009 | β |
| Methotrexate pharmacogenomics in rheumatoid arthritis: introducing false-positive report probability. | Dervieux T | β | 2009 | β |
| Microarray analysis of multiple candidate genes and associated plasma proteins for nephropathy secondary to type 2 diabetes among Chinese individuals. | Lim SC et al. | β | 2009 | β |
| Multilocus Bayesian meta-analysis of gene-disease associations. | Newcombe PJ et al. | β | 2009 | β |
| Myocilin polymorphisms and high myopia in subjects of European origin. | Zayats T et al. | β | 2009 | β |
| No evidence for association between the renin-angiotensin-aldosterone system and otosclerosis in a large Belgian-Dutch population. | Schrauwen I et al. | β | 2009 | β |
| No relationship between 2',3'-cyclic nucleotide 3'-phosphodiesterase and schizophrenia in the Chinese Han population: an expression study and meta-analysis. | Che R et al. | β | 2009 | β |
| Pharmacogenetics of nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy. | Kallianpur AR et al. | β | 2009 | β |
| Pharmacogenomics of adverse drug reactions: practical applications and perspectives. | Becquemont L | β | 2009 | β |
| Prothrombotic genetic variants and atherosclerosis in patients with cerebral ischemia of arterial origin. | Pruissen DM et al. | β | 2009 | β |
| [Public health genomics. The future is built today!]. | Brand A et al. | β | 2009 | β |
| Reassessing the impact of donor HLA-C genotype on long-term liver transplant survival. | Tran TH et al. | β | 2009 | β |
| Replication of genetic associations as pseudoreplication due to shared genealogy. | Rosenberg NA et al. | β | 2009 | β |
| Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex. | Viken MK et al. | β | 2009 | β |
| Role of the ACE ID and MTHFR C677T polymorphisms in genetic susceptibility of migraine in a north Indian population. | Joshi G et al. | β | 2009 | β |
| Role played by human mannose-binding lectin polymorphisms in pulmonary tuberculosis. | Capparelli R et al. | β | 2009 | β |
| Searching genetic risk factors for schizophrenia and bipolar disorder: learn from the past and back to the future. | Alaerts M et al. | β | 2009 | β |
| Sequence variations of the human MPDZ gene and association with alcoholism in subjects with European ancestry. | Karpyak VM et al. | β | 2009 | β |
| Strengthening the reporting of genetic association studies (STREGA): an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement. | Little J et al. | β | 2009 | β |
| Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement. | Little J et al. | β | 2009 | β |
| Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement. | Little J et al. | β | 2009 | β |
| STrengthening the REporting of Genetic Association studies (STREGA)--an extension of the STROBE statement. | Little J et al. | β | 2009 | β |
| STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement. | Little J et al. | β | 2009 | β |
| STrengthening the REporting of Genetic Association Studies (STREGA)--an extension of the STROBE statement. | Little J et al. | β | 2009 | β |
| STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. | Little J et al. | β | 2009 | β |
| The phenotype and genotype of adult obstructive sleep apnoea/hypopnoea syndrome. | Riha RL et al. | β | 2009 | β |
| The quality of meta-analyses of genetic association studies: a review with recommendations. | Minelli C et al. | β | 2009 | β |
| Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema. | Hersh CP et al. | β | 2009 | β |
| Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI. | Shugart YY et al. | β | 2009 | β |
| A genome-wide association study for late-onset Alzheimer's disease using DNA pooling. | Abraham R et al. | β | 2008 | β |
| A polymorphism in the human serotonin 5-HT2A receptor gene may protect against systemic sclerosis by reducing platelet aggregation. | Beretta L et al. | β | 2008 | β |
| A review of current approaches to identifying human genes involved in myopia. | Tang WC et al. | β | 2008 | β |
| Association of bone morphogenetic proteins with otosclerosis. | Schrauwen I et al. | β | 2008 | β |
| Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome. | Barber TM et al. | β | 2008 | β |
| Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer. | Song H et al. | β | 2008 | β |
| A systematic review of meta-analyses on gene polymorphisms and gastric cancer risk. | Gianfagna F et al. | β | 2008 | β |
| Bayesian meta-analysis of genetic association studies with different sets of markers. | Verzilli C et al. | β | 2008 | β |
| Biostatistical aspects of genome-wide association studies. | Ziegler A et al. | β | 2008 | β |
| Casein kinase I epsilon (CKIvarepsilon) N408 allele is very rare in the Brazilian population and is not involved in susceptibility to circadian rhythm sleep disorders. | Castro RM et al. | β | 2008 | β |
| Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes. | Hettema JM et al. | β | 2008 | β |
| Coagulation factor XIII gene variation, oral contraceptives, and risk of ischemic stroke. | Pruissen DM et al. | β | 2008 | β |
| Combined effect of hemostatic gene polymorphisms and the risk of myocardial infarction in patients with advanced coronary atherosclerosis. | Martinelli N et al. | β | 2008 | β |
| Common genetic variation and human disease. | Orr N et al. | β | 2008 | β |
| Community versus clinic sampling: effect on the familial aggregation of anxiety disorders. | Low NC et al. | β | 2008 | β |
| Consortium analysis of 7 candidate SNPs for ovarian cancer. | Ramus SJ et al. | β | 2008 | β |
| Controlling false discoveries in genetic studies. | van den Oord EJ | β | 2008 | β |
| Effects of an attachment-based intervention on daily cortisol moderated by dopamine receptor D4: a randomized control trial on 1- to 3-year-olds screened for externalizing behavior. | Bakermans-Kranenburg MJ et al. | β | 2008 | β |
| Epistatic interactions are critical to gene-association studies: PAI-1 and risk for mortality after burn injury. | Barber RC et al. | β | 2008 | β |
| Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia. | Campbell DB et al. | β | 2008 | β |
| Evaluation of EGR1 as a candidate gene for high myopia. | Li T et al. | β | 2008 | β |
| False-positive results in cancer epidemiology: a plea for epistemological modesty. | Boffetta P et al. | β | 2008 | β |
| Function2Gene: a gene selection tool to increase the power of genetic association studies by utilizing public databases and expert knowledge. | Armstrong DL et al. | β | 2008 | β |
| GABABR1 (G1465A) gene variation and temporal lobe epilepsy controversy: new evidence. | Kauffman MA et al. | β | 2008 | β |
| Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. | van Os J et al. | β | 2008 | β |
| Genes and the preeclampsia syndrome. | MΓΌtze S et al. | β | 2008 | β |
| Genes for multiple sclerosis. | Ramagopalan SV et al. | β | 2008 | β |
| Genetic polymorphisms and the fate of the transplanted organ. | KrΓΌger B et al. | β | 2008 | β |
| Genetic polymorphisms in the renin-angiotensin system confer increased risk of stroke independently of blood pressure: a nested case-control study. | MΓΆllsten A et al. | β | 2008 | β |
| Genetic profiling in healthy subjects from the Stanislas cohort based on 24 polymorphisms: effects on biological variables. | Albuisson E et al. | β | 2008 | β |
| Genetic susceptibility loci for breast cancer by estrogen receptor status. | Garcia-Closas M et al. | β | 2008 | β |
| Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. | Liu YJ et al. | β | 2008 | β |
| Genome-wide linkage scan for the metabolic syndrome: the GENNID study. | Edwards KL et al. | β | 2008 | β |
| Heme oxygenase 1: does it have a role in renal cytoprotection? | Courtney AE et al. | β | 2008 | β |
| Hypercalciuria revisited: one or many conditions? | Vezzoli G et al. | β | 2008 | β |
| Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension. | Kohara K et al. | β | 2008 | β |
| Identification of interleukin-6 promoter polymorphisms in the Chinese Han population and their functional significance. | Gu W et al. | β | 2008 | β |
| Insight into the genetics of hypertension, a core component of the metabolic syndrome. | Pravenec M et al. | β | 2008 | β |
| Interleukin-10 gene polymorphism is associated with alcoholism but not with alcoholic liver disease. | Marcos M et al. | β | 2008 | β |
| Is Mendelian randomization 'lost in translation?': comments on 'Mendelian randomization equals instrumental variable analysis with genetic instruments' by Wehby et al. | Lawlor DA et al. | β | 2008 | β |
| Is replication the gold standard for validating genome-wide association findings? | Liu YJ et al. | β | 2008 | β |
| Lack of association between genetic variation in G-protein-coupled receptor for asthma susceptibility and childhood asthma and atopy. | Wu H et al. | β | 2008 | β |
| Lack of association of VDR gene polymorphisms with thyroid autoimmune disorders: familial and case/control studies. | Maalej A et al. | β | 2008 | β |
| Marker-assisted assessment of genotype by environment interaction: a case study of single nucleotide polymorphism-mortality association in broilers in two hygiene environments. | Long N et al. | β | 2008 | β |
| Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. | Lawlor DA et al. | β | 2008 | β |
| Meta-analysis methods. | Trikalinos TA et al. | β | 2008 | β |
| Meta-analysis of genetic association studies under different inheritance models using data reported as merged genotypes. | Salanti G et al. | β | 2008 | β |
| Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism. | Barnett JH et al. | β | 2008 | β |
| Methodological quality of pharmacogenetic studies: issues of concern. | Jorgensen AL et al. | β | 2008 | β |
| National Emphysema Treatment Trial state of the art: genetics of emphysema. | Hersh CP et al. | β | 2008 | β |
| No association between common Gly972Arg variant of the insulin receptor substrate-1 and polycystic ovary syndrome in Southern Chilean women. | ValdΓ©s P et al. | β | 2008 | β |
| No significant association between the genetic polymorphisms in the GSK-3 beta gene and schizophrenia in the Chinese population. | Meng J et al. | β | 2008 | β |
| Perspective on the genetics of attention deficit/hyperactivity disorder. | Neale BM et al. | β | 2008 | β |
| Pharmacogenomics in Alzheimer's disease. | Cacabelos R | β | 2008 | β |
| Physiogenomic analysis of localized FMRI brain activity in schizophrenia. | Windemuth A et al. | β | 2008 | β |
| Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions. | Mechanic LE et al. | β | 2008 | β |
| Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis. | Zhao ZZ et al. | β | 2008 | β |
| Polymorphisms of the cannabinoid 1 receptor gene and cognitive impairment in multiple sclerosis. | Woolmore J et al. | β | 2008 | β |
| Proteomic Biomarkers of Atherosclerosis. | Vivanco F et al. | β | 2008 | β |
| Prothrombotic gene variation and new vascular events after cerebral ischemia of arterial origin. | Pruissen DM et al. | β | 2008 | β |
| Reappraisal of the role of the DRD3 gene in essential tremor. | Blair MA et al. | β | 2008 | β |
| Recent advances in atherosclerosis-based proteomics: new biomarkers and a future perspective. | Alvarez-Llamas G et al. | β | 2008 | β |
| Renin-angiotensin system gene polymorphisms and diastolic heart failure. | Wu CK et al. | β | 2008 | β |
| Replication of associations between LRP5 and ESRRA variants and bone density in premenopausal women. | Giroux S et al. | β | 2008 | β |
| Reporting and interpretation in genome-wide association studies. | Wakefield J | β | 2008 | β |
| Reporting of human genome epidemiology (HuGE) association studies: an empirical assessment. | Yesupriya A et al. | β | 2008 | β |
| Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysis. | Sagoo GS et al. | β | 2008 | β |
| Specificity of familial transmission of anxiety and comorbid disorders. | Low NC et al. | β | 2008 | β |
| Strengthening causal inference in cardiovascular epidemiology through Mendelian randomization. | Smith GD et al. | β | 2008 | β |
| Substance dependence low-density whole genome association study in two distinct American populations. | Yu Y et al. | β | 2008 | β |
| Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. | Broadbent HM et al. | β | 2008 | β |
| Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches. | Zintzaras E et al. | β | 2008 | β |
| T64A polymorphism in beta3-adrenergic receptor gene (ADRB3) and coronary heart disease: a case-cohort study and meta-analysis. | Zafarmand MH et al. | β | 2008 | β |
| The association between genetic variants in hMLH1 and hMSH2 and the development of sporadic colorectal cancer in the Danish population. | Christensen LL et al. | β | 2008 | β |
| The genetics of nicotine addiction liability: ethical and social policy implications. | Hall WD et al. | β | 2008 | β |
| The M235T variant of the angiotensinogen gene is related to development of self-reported hypertension during pregnancy: the Prospect-EPIC cohort study. | Zafarmand MH et al. | β | 2008 | β |
| The polymorphism of the serotonin-2A receptor T102C is associated with age. | Jobim PF et al. | β | 2008 | β |
| The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency. | Wood AM et al. | β | 2008 | β |
| Trends in meta-analysis of genetic association studies. | Zintzaras E et al. | β | 2008 | β |
| Two polymorphisms in NEDD4L gene and essential hypertension in Chinese Hans - a population-based case-control study. | Wen H et al. | β | 2008 | β |
| Update on primary hypercalciuria from a genetic perspective. | Vezzoli G et al. | β | 2008 | β |
| Update on the genetics of nephrolithiasis. | Vezzoli G et al. | β | 2008 | β |
| What have we learned from prospective cohort studies of asthma in children? | Henderson AJ | β | 2008 | β |
| Worldwide genetic variation in dopamine and serotonin pathway genes: implications for association studies. | Gardner M et al. | β | 2008 | β |
| A Bayesian measure of the probability of false discovery in genetic epidemiology studies. | Wakefield J | β | 2007 | β |
| ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research. | Leschziner GD et al. | β | 2007 | β |
| A common coding variant in CASP8 is associated with breast cancer risk. | Cox A et al. | β | 2007 | β |
| A follow-up study of Nordic multiple sclerosis candidate gene regions. | Datta P et al. | β | 2007 | β |
| A generic research paradigm for identification and validation of early molecular diagnostics and new therapeutics in common disorders. | Coon KD et al. | β | 2007 | β |
| AKT1 and neurocognition in schizophrenia. | Pinheiro AP et al. | β | 2007 | β |
| ALOX5AP gene variants and risk of coronary artery disease: an angiography-based study. | Girelli D et al. | β | 2007 | β |
| AMI is associated with polymorphisms in the NOS3 and FGB but not in PAI-1 genes in young adults. | Sampaio MF et al. | β | 2007 | β |
| A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array. | Hanson RL et al. | β | 2007 | β |
| Assessing theoretical risk and benefit suggested by genetic association studies of CCR5: experience in a drug development programme for maraviroc. | Wheeler J et al. | β | 2007 | β |
| Association between vitamin-D receptor gene FokI polymorphism and Graves' disease among Taiwanese Chinese. | Chen RH et al. | β | 2007 | β |
| Association of functional heme oxygenase-1 gene promoter polymorphism with renal transplantation outcomes. | Courtney AE et al. | β | 2007 | β |
| Bayesian meta-analysis and meta-regression for gene-disease associations and deviations from Hardy-Weinberg equilibrium. | Salanti G et al. | β | 2007 | β |
| Beta2-adrenoceptor polymorphisms and obstructive airway diseases: important issues of study design. | Yang IA et al. | β | 2007 | β |
| Catechol-o-methyltransferase polymorphism and susceptibility to major depressive disorder modulates psychological stress response. | Jabbi M et al. | β | 2007 | β |
| Clustering of autoimmune disease in families at high risk for multiple sclerosis? | Ramagopalan SV et al. | β | 2007 | β |
| Commentary: rare alleles, modest genetic effects and the need for collaboration. | Campbell H et al. | β | 2007 | β |
| Commentary: Reflections on G. M. Lower and colleagues' 1979 study associating slow acetylator phenotype with urinary bladder cancer: meta-analysis, historical refinements of the hypothesis, and lessons learned. | Rothman N et al. | β | 2007 | β |
| Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects. | Owen KR et al. | β | 2007 | β |
| Comprehensive testing of positionally cloned asthma genes in two populations. | Hersh CP et al. | β | 2007 | β |
| Contribution of 20 single nucleotide polymorphisms of 13 genes to dyslipidemia associated with antiretroviral therapy. | Arnedo M et al. | β | 2007 | β |
| Cytotoxic T-lymphocyte-associated antigen-4 single nucleotide polymorphisms and haplotypes in primary biliary cirrhosis. | Donaldson P et al. | β | 2007 | β |
| Direct, reverse or reciprocal causation in the relation between homocysteine and ischemic heart disease. | Grassi M et al. | β | 2007 | β |
| Disparities in infant mortality: what's genetics got to do with it? | David R et al. | β | 2007 | β |
| Endometriosis and genetic polymorphisms. | Falconer H et al. | β | 2007 | β |
| Exploring design-related bias in clinical studies on receptor genetic polymorphism of hypertension. | Farahani P et al. | β | 2007 | β |
| Fine mapping versus replication in whole-genome association studies. | Clarke GM et al. | β | 2007 | β |
| Gene discovery in diabetic nephropathy. | Savage DA et al. | β | 2007 | β |
| Genes, environments, development and asthma: a reappraisal. | Martinez FD | β | 2007 | β |
| Genetic approaches to polycystic ovarian syndrome. | Menke MN et al. | β | 2007 | β |
| Genetic epidemiology of primary sclerosing cholangitis. | Karlsen TH et al. | β | 2007 | β |
| Genetic influences on outcome following traumatic brain injury. | Jordan BD | β | 2007 | β |
| Genetic polymorphisms and idiopathic generalized epilepsies. | Lucarini N et al. | β | 2007 | β |
| Genetics in psychosomatic medicine: research designs and statistical approaches. | McCaffery JM et al. | β | 2007 | β |
| Genetics of asthma: potential implications for reducing asthma disparities. | Scirica CV et al. | β | 2007 | β |
| Genetics of polycystic ovarian syndrome. | Nam Menke M et al. | β | 2007 | β |
| Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients. | Blair MA et al. | β | 2007 | β |
| Genetic variation in the cytochrome P450 epoxygenase pathway and cardiovascular disease risk. | Theken KN et al. | β | 2007 | β |
| Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. | Wellcome Trust Case Control Consortium | β | 2007 | β |
| Haematopoietic stem cell transplantation: can our genes predict clinical outcome? | Dickinson AM et al. | β | 2007 | β |
| Heritability of ischaemic stroke in women compared with men: a genetic epidemiological study. | TouzΓ© E et al. | β | 2007 | β |
| Identification of novel susceptibility genes in childhood-onset systemic lupus erythematosus using a uniquely designed candidate gene pathway platform. | Jacob CO et al. | β | 2007 | β |
| Identification of PVT1 as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association study. | Hanson RL et al. | β | 2007 | β |
| Impact of genetic variants in IL-4, IL-4 RA and IL-13 on the anti-pneumococcal antibody response. | Wiertsema SP et al. | β | 2007 | β |
| Is chronic fatigue syndrome (CFS/ME) heritable in children, and if so, why does it matter? | Crawley E et al. | β | 2007 | β |
| Is the serotonin transporter polymorphism (5-HTTLPR) associated with harm avoidance and internalising problems in childhood and adolescence? | Becker K et al. | β | 2007 | β |
| LGALS2 functional variant rs7291467 is not associated with susceptibility to myocardial infarction in Caucasians. | Mangino M et al. | β | 2007 | β |
| Linkage and association of myocilin (MYOC) polymorphisms with high myopia in a Chinese population. | Tang WC et al. | β | 2007 | β |
| Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mouse. | SolcΓ C et al. | β | 2007 | β |
| Mechanisms of disease: The genetic basis of coronary heart disease. | Kullo IJ et al. | β | 2007 | β |
| Microsatellites and genome scans-- a GAMES postscript. | Dyment DA et al. | β | 2007 | β |
| NCAM1 and neurocognition in schizophrenia. | Sullivan PF et al. | β | 2007 | β |
| No association between the genetic polymorphisms in the RTN4R gene and schizophrenia in the Chinese population. | Meng J et al. | β | 2007 | β |
| No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis. | Ramagopalan SV et al. | β | 2007 | β |
| No gene is an island: the flip-flop phenomenon. | Lin PI et al. | β | 2007 | β |
| Non-replication of association studies: "pseudo-failures" to replicate? | Gorroochurn P et al. | β | 2007 | β |
| No significant association between response to methylphenidate and genes of the dopaminergic and serotonergic systems in a sample of Brazilian children with attention-deficit/hyperactivity disorder. | Zeni CP et al. | β | 2007 | β |
| p53: it has it all, but will it make it to the clinic as a marker in bladder cancer? | Real FX | β | 2007 | β |
| Proteomic applications in ecotoxicology. | Monsinjon T et al. | β | 2007 | β |
| Quality in epidemiological research: should we be submitting papers before we have the results and submitting more hypothesis-generating research? | Lawlor DA | β | 2007 | β |
| Re: Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium. | Baker SG | β | 2007 | β |
| Relationship between E23K (an established type II diabetes-susceptibility variant within KCNJ11), polycystic ovary syndrome and androgen levels. | Barber TM et al. | β | 2007 | β |
| Replicating genotype-phenotype associations. | NCI-NHGRI Working Group on Replication in Association Studies et al. | β | 2007 | β |
| Risk assessment in haematopoietic stem cell transplantation: pre-transplant patient and donor factors: non-HLA genetics. | Dickinson AM | β | 2007 | β |
| Searching for alleles associated with complicated outcomes after burn injury. | Barber RC et al. | β | 2007 | β |
| Spurious genetic associations. | Sullivan PF | β | 2007 | β |
| Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. | Bertram L et al. | β | 2007 | β |
| The association of the paraoxonase (PON1) Q192R polymorphism with depression in older women: findings from the British Women's Heart and Health Study. | Lawlor DA et al. | β | 2007 | β |
| The brain-derived neurotrophic factor Val66Met polymorphism is associated with sense of coherence in a non-clinical community sample of 7335 adults. | Surtees PG et al. | β | 2007 | β |
| The discoidin domain receptor 1 as a novel susceptibility gene for schizophrenia. | Roig B et al. | β | 2007 | β |
| The emergence of networks in human genome epidemiology: challenges and opportunities. | Seminara D et al. | β | 2007 | β |
| The met(158) allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis. | Pooley EC et al. | β | 2007 | β |
| The power and limitations of pharmacogenetic epidemiology. | Lapane K et al. | β | 2007 | β |
| Tissue inhibitor of metalloproteinase-1 (TIMP-1) polymorphisms in a Caucasian population with abdominal aortic aneurysm. | Hinterseher I et al. | β | 2007 | β |
| TNFA2 and d2 alleles of the tumor necrosis factor alpha gene polymorphism are associated with onset/occurrence of idiopathic membranous nephropathy. | Thibaudin D et al. | β | 2007 | β |
| Toxicogenetics of antiretroviral therapy: genetic factors that contribute to metabolic complications. | Tarr PE et al. | β | 2007 | β |
| Tumour necrosis factor gene complex polymorphisms in chronic obstructive pulmonary disease. | Ruse CE et al. | β | 2007 | β |
| Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians. | Ma L et al. | β | 2007 | β |
| Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery. | Hersh CP et al. | β | 2007 | β |
| A brief targeted review of susceptibility factors, environmental exposures, asthma incidence, and recommendations for future asthma incidence research. | Yeatts K et al. | β | 2006 | β |
| Absence of association between the multidrug resistance (MDR1) gene and inflammatory bowel disease. | Oostenbrug LE et al. | β | 2006 | β |
| A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Koreans. | Kang CP et al. | β | 2006 | β |
| A genome-wide DNA microsatellite association screen to identify chromosomal regions harboring candidate genes in diabetic nephropathy. | McKnight AJ et al. | β | 2006 | β |
| Alpha2C-adrenoceptor polymorphism is associated with improved event-free survival in patients with dilated cardiomyopathy. | Regitz-Zagrosek V et al. | β | 2006 | β |
| Apolipoprotein epsilon3 allele is associated with persistent hepatitis C virus infection. | Price DA et al. | β | 2006 | β |
| Are we ready for genome-wide association studies? | Thomas DC | β | 2006 | β |
| Association analysis of MYO9B gene polymorphisms and inflammatory bowel disease in a Norwegian cohort. | Amundsen SS et al. | β | 2006 | β |
| Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort. | Amundsen SS et al. | β | 2006 | β |
| Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations. | Lundmark F et al. | β | 2006 | β |
| Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism. | Hettema JM et al. | β | 2006 | β |
| Association between interleukin-1 receptor antagonist gene and asthma-related traits in a German adult population. | Pattaro C et al. | β | 2006 | β |
| Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes. | Maier LM et al. | β | 2006 | β |
| Association of the promoter polymorphism -232C/G of the phosphoenolpyruvate carboxykinase gene (PCK1) with Type 2 diabetes mellitus. | Gouni-Berthold I et al. | β | 2006 | β |
| Biomarkers of cardiovascular disease: molecular basis and practical considerations. | Vasan RS | β | 2006 | β |
| Can we increase the likelihood of success for future association studies in epilepsy? | Durner M et al. | β | 2006 | β |
| CARD15 in inflammatory bowel disease and Crohn's disease phenotypes: an association study and pooled analysis. | Oostenbrug LE et al. | β | 2006 | β |
| Case-control genetic association studies in gastrointestinal disease: review and recommendations. | Saito YA et al. | β | 2006 | β |
| Case-control studies in the genomic era: a clinician's guide. | Healy DG | β | 2006 | β |
| CC-chemokine receptor five gene polymorphism in primary IgA nephropathy: the 32 bp deletion allele is associated with late progression to end-stage renal failure with dialysis. | Berthoux FC et al. | β | 2006 | β |
| Challenges of SNP genotyping and genetic variation: its future role in diagnosis and treatment of cancer. | Bernig T et al. | β | 2006 | β |
| Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium. | Breast Cancer Association Consortium | β | 2006 | β |
| Common susceptibility genes for cancer: search for the end of the rainbow. | Baker SG et al. | β | 2006 | β |
| COMT Val108/158Met gene variant, birth weight, and conduct disorder in children with ADHD. | Sengupta SM et al. | β | 2006 | β |
| Detecting genetic predisposition for complicated clinical outcomes after burn injury. | Barber RC et al. | β | 2006 | β |
| [Diagnostic and therapeutic activity moderation. Quaternary and genetic prevention]. | GΓ©rvas J | β | 2006 | β |
| Dissecting complex disease: the quest for the Philosopher's Stone? | Buchanan AV et al. | β | 2006 | β |
| Does cannabis use cause schizophrenia? | Macleod J et al. | β | 2006 | β |
| Endothelial nitric oxide synthase G894T gene polymorphism in Chilean subjects with coronary artery disease and controls. | Jaramillo PC et al. | β | 2006 | β |
| Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and development of pre-eclampsia: a case-control study and a meta-analysis. | Yu CK et al. | β | 2006 | β |
| Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review. | Casas JP et al. | β | 2006 | β |
| Factor XIII Val34Leu variant is protective against venous thromboembolism: a HuGE review and meta-analysis. | Wells PS et al. | β | 2006 | β |
| Fetal and maternal peroxisome proliferator-activated receptor gamma2 Pro12Ala does not influence birth weight. | Pfab T et al. | β | 2006 | β |
| Finding the molecular basis of complex genetic variation in humans and mice. | Mott R | β | 2006 | β |
| Follow-up investigation of 12 proposed linkage regions in multiple sclerosis. | Herrera BM et al. | β | 2006 | β |
| FOXP3 polymorphisms in type 1 diabetes and coeliac disease. | BjΓΈrnvold M et al. | β | 2006 | β |
| Gender-specific associations between MICA-STR and nasopharyngeal carcinoma in a southern Chinese Han population. | Tian W et al. | β | 2006 | β |
| Gene-environment interactions in asthma. | Castro-Giner F et al. | β | 2006 | β |
| Gene-environment interactions in psychiatry: joining forces with neuroscience. | Caspi A et al. | β | 2006 | β |
| Gene-environment interplay and psychopathology: multiple varieties but real effects. | Rutter M et al. | β | 2006 | β |
| Genetic associations in preterm birth: a primer of marker selection, study design, and data analysis. | Menon R et al. | β | 2006 | β |
| Genetic association studies: where are we now? | Savage SA | β | 2006 | β |
| Genetic dissection of the common epilepsies. | Tan NC et al. | β | 2006 | β |
| Genetic epidemiology and primary care. | Smith BH et al. | β | 2006 | β |
| Genetics of disc degeneration. | Chan D et al. | β | 2006 | β |
| Genetic susceptibility to coronary artery disease: from promise to progress. | Watkins H et al. | β | 2006 | β |
| Genetic variability in the extracellular matrix protein as a determinant of risk for developing HTLV-I-associated neurological disease. | Nobuhara Y et al. | β | 2006 | β |
| Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium. | Rothman N et al. | β | 2006 | β |
| Genomic boundaries between human populations. | Barbujani G et al. | β | 2006 | β |
| Genomics and complex liver disease: Challenges and opportunities. | Juran BD et al. | β | 2006 | β |
| Genomics meets HIV-1. | Telenti A et al. | β | 2006 | β |
| Genotype combinations of plasminogen activator inhibitor-1 and angiotensin-converting enzyme genes and risk for early onset of coronary heart disease. | Loew M et al. | β | 2006 | β |
| Glu298Asp and NOS4ab polymorphisms in diabetic nephropathy. | MΓΆllsten A et al. | β | 2006 | β |
| Hair dye use is not associated with risk for bladder cancer: evidence from a case-control study in Spain. | Kogevinas M et al. | β | 2006 | β |
| HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to breast cancer. | Benusiglio PR et al. | β | 2006 | β |
| High-throughput genomic technology in research and clinical management of breast cancer. Evolving landscape of genetic epidemiological studies. | Low YL et al. | β | 2006 | β |
| Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C. | Huang H et al. | β | 2006 | β |
| Implications of gene-environment interaction in studies of gene variants in breast cancer: an example of dietary isoflavones and the D356N polymorphism in the sex hormone-binding globulin gene. | Low YL et al. | β | 2006 | β |
| Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases. | Ioannidis JP et al. | β | 2006 | β |
| Influence of graft characteristics on the outcome of kidney transplantation. | Soulillou JP et al. | β | 2006 | β |
| Intronic variants in the dopa decarboxylase (DDC) gene are associated with smoking behavior in European-Americans and African-Americans. | Yu Y et al. | β | 2006 | β |
| Investigating the genetic determinants of cardiovascular disease using candidate genes and meta-analysis of association studies. | Casas JP et al. | β | 2006 | β |
| Investigation of genetic association between human Frizzled homolog 3 gene (FZD3) and schizophrenia: results in a Korean population and evidence from meta-analysis. | Jeong SH et al. | β | 2006 | β |
| Is the association between cigarette smoking and breast cancer modified by genotype? A review of epidemiologic studies and meta-analysis. | Terry PD et al. | β | 2006 | β |
| Lack of association between C3435T nucleotide MDR1 genetic polymorphism and multidrug-resistant epilepsy. | Kim DW et al. | β | 2006 | β |
| Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans. | Games Collaborative Group et al. | β | 2006 | β |
| Measured Gene-Environment Interactions in Psychopathology: Concepts, Research Strategies, and Implications for Research, Intervention, and Public Understanding of Genetics. | Moffitt TE et al. | β | 2006 | β |
| 'Medicine's next goldmine?' The implications of new genetic health technologies for the health service. | Calnan M et al. | β | 2006 | β |
| MPZL1/PZR, a novel candidate predisposing schizophrenia in Han Chinese. | He G et al. | β | 2006 | β |
| Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. | Harrison PJ et al. | β | 2006 | β |
| No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis. | Wiencke K et al. | β | 2006 | β |
| Optimum two-stage designs in case-control association studies using false discovery rate. | Kuchiba A et al. | β | 2006 | β |
| Pharmacogenetics: progress, pitfalls and clinical potential for coronary heart disease. | Humphries SE et al. | β | 2006 | β |
| Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis. | Karlsen TH et al. | β | 2006 | β |
| Promoter genetic variants of prostanoid DP receptor (PTGDR) gene in patients with asthma. | Sanz C et al. | β | 2006 | β |
| Randomised by (your) god: robust inference from an observational study design. | Smith GD | β | 2006 | β |
| Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes. | RodrΓguez S et al. | β | 2006 | β |
| Replication of small effect quantitative trait loci for behavioral traits facilitated by estimation of effect size from independent cohorts. | Bennett B et al. | β | 2006 | β |
| RGS4 polymorphisms and risk of schizophrenia: an association study in Han Chinese plus meta-analysis. | Guo S et al. | β | 2006 | β |
| Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes. | Hill DA et al. | β | 2006 | β |
| Searching for genetic clues to the causes of pre-eclampsia. | Chappell S et al. | β | 2006 | β |
| Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls. | Ye Z et al. | β | 2006 | β |
| Significant association between the genetic variations in the 5' end of the N-methyl-D-aspartate receptor subunit gene GRIN1 and schizophrenia. | Zhao X et al. | β | 2006 | β |
| Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. | Surtees PG et al. | β | 2006 | β |
| Systematic replication study of reported genetic associations in prostate cancer: Strong support for genetic variation in the androgen pathway. | LindstrΓΆm S et al. | β | 2006 | β |
| Tackling the genetic bases of metabolic syndrome: a realistic objective? | Siani A et al. | β | 2006 | β |
| Testing of variants of the MTHFR and ESR1 genes in 1798 Finnish individuals fails to confirm the association with migraine with aura. | Kaunisto MA et al. | β | 2006 | β |
| The association of oestrogen receptor alpha-haplotypes with cardiovascular risk factors in the British Women's Heart and Health Study. | Lawlor DA et al. | β | 2006 | β |
| The association of the PON1 Q192R polymorphism with complications and outcomes of pregnancy: findings from the British Women's Heart and Health cohort study. | Lawlor DA et al. | β | 2006 | β |
| The Cys allele of the DRD2 Ser311Cys polymorphism has a dominant effect on risk for schizophrenia: evidence from fixed- and random-effects meta-analyses. | Glatt SJ et al. | β | 2006 | β |
| The merits of testing Hardy-Weinberg equilibrium in the analysis of unmatched case-control data: a cautionary note. | Zou GY et al. | β | 2006 | β |
| The publication process itself was the major cause of publication bias in genetic epidemiology. | Calnan M et al. | β | 2006 | β |
| The role of genetic polymorphisms in alcoholic liver disease. | Stickel F et al. | β | 2006 | β |
| The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis. | Lewis SJ et al. | β | 2006 | β |
| Thrombospondin-4 1186G>C (A387P) is a sex-dependent risk factor for myocardial infarction: a large replication study with increased sample size from the same population. | Cui J et al. | β | 2006 | β |
| Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis. | Garnacho-Montero J et al. | β | 2006 | β |
| Toll-like receptor (TLR) 4 polymorphism Asp299Gly is not associated with disease course in Dutch sarcoidosis patients. | Veltkamp M et al. | β | 2006 | β |
| Translating knowledge of the human genome into clinical practice in nephrology dialysis and transplantation: the renal genome network (ReGeNet). | Brenchley PE et al. | β | 2006 | β |
| Variants implicated in cortisone reductase deficiency do not contribute to susceptibility to common forms of polycystic ovary syndrome. | Draper N et al. | β | 2006 | β |
| Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study. | Chan KC et al. | β | 2005 | β |
| ACE genotype and long-term graft survival after renal transplantation. | Navis G | β | 2005 | β |
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| A meta-analysis of the MTHFR C677T polymorphism and schizophrenia risk. | Lewis SJ et al. | β | 2005 | β |
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| Asthma genetics: pitfalls and triumphs. | Carroll W | β | 2005 | β |
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| Common variation in EMSY and risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs. | Benusiglio PR et al. | β | 2005 | β |
| Comprehensive genetic evaluation of common E-cadherin sequence variants and prostate cancer risk: strong confirmation of functional promoter SNP. | LindstrΓΆm S et al. | β | 2005 | β |
| COMT polymorphisms and anxiety-related personality traits. | Stein MB et al. | β | 2005 | β |
| Conventional P-values fail to assure reproducibility for genetic association tests. | Manly KF | β | 2005 | β |
| CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis. | Lee YH et al. | β | 2005 | β |
| Developing academic-practice partnerships to enhance the integration of genomics into public health. | Raup SF et al. | β | 2005 | β |
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| Disentangling fetal and maternal susceptibility for pre-eclampsia: a British multicenter candidate-gene study. | GOPEC Consortium | β | 2005 | β |
| Does elevated plasma fibrinogen increase the risk of coronary heart disease? Evidence from a meta-analysis of genetic association studies. | Smith GD et al. | β | 2005 | β |
| Does the Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism modify the response to ACE inhibitor therapy?--A systematic review. | Scharplatz M et al. | β | 2005 | β |
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| Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. | Ogata T et al. | β | 2005 | β |
| Genetic association studies in stroke: methodological issues and proposed standard criteria. | Dichgans M et al. | β | 2005 | β |
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| Genetic factors contribute to bleeding after cardiac surgery. | Welsby IJ et al. | β | 2005 | β |
| Genetic polymorphisms and cerebral palsy in very preterm infants. | Nelson KB et al. | β | 2005 | β |
| Genetics and genotypes in irritable bowel syndrome: implications for diagnosis and treatment. | Park MI et al. | β | 2005 | β |
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| Genetics of common progressive renal disease. | Chow KM et al. | β | 2005 | β |
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| Genetics of fibrosing lung diseases. | Grutters JC et al. | β | 2005 | β |
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| Genetic variations of tubular sodium reabsorption leading to "primary" hypertension: from gene polymorphism to clinical symptoms. | Bianchi G | β | 2005 | β |
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| Genomic epidemiology of complex disease: the need for an electronic evidence-based approach to research synthesis. | Bracken MB | β | 2005 | β |
| Guidelines for association studies in Human Molecular Genetics. | Freimer NB et al. | β | 2005 | β |
| Haplotyping by capillary electrophoresis. | Szantai E et al. | β | 2005 | β |
| Host genetics and the outcome of hepatitis B viral infection. | Frodsham AJ | β | 2005 | β |
| Identification of genetic risk factors for periodontitis and possible mechanisms of action. | Loos BG et al. | β | 2005 | β |
| Immunopathogenesis and immunotherapeutic approaches in multiple sclerosis. | Lim ET et al. | β | 2005 | β |
| Interleukin-10 promoter polymorphisms and atopic asthma in North Indians. | Chatterjee R et al. | β | 2005 | β |
| Interleukin 18 promoter polymorphisms are not strongly associated with type I diabetes in a UK population. | Martin RJ et al. | β | 2005 | β |
| Interleukin-4 (IL4) and Interleukin-4 receptor (IL4RA) polymorphisms in asthma: a case control study. | Isidoro-GarcΓa M et al. | β | 2005 | β |
| Interleukin-6 -174G/C polymorphism and longevity: a follow-up study. | Hurme M et al. | β | 2005 | β |
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| Kawasaki disease: what is the epidemiology telling us about the etiology? | Burgner D et al. | β | 2005 | β |
| Key concepts in genetic epidemiology. | Burton PR et al. | β | 2005 | β |
| Lack of GABABR1 gene variation (G1465A) in a Chinese population with temporal lobe epilepsy. | Ren L et al. | β | 2005 | β |
| Lack of support for the presence of an osteoarthritis susceptibility locus on chromosome 6p. | Meenagh GK et al. | β | 2005 | β |
| Making the right associations. | McCarthy MI et al. | β | 2005 | β |
| Meta-analysis of genetic studies using Mendelian randomization--a multivariate approach. | Thompson JR et al. | β | 2005 | β |
| Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? | Lewis SJ et al. | β | 2005 | β |
| Methylenetetrahydrofolate reductase (MTHFR) and susceptibility for (pre)neoplastic cervical disease. | Zoodsma M et al. | β | 2005 | β |
| NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses. | GarcΓa-Closas M et al. | β | 2005 | β |
| No association of the NFKB1 promoter polymorphism with ulcerative colitis in a British case control cohort. | Mirza MM et al. | β | 2005 | β |
| No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes. | Maier LM et al. | β | 2005 | β |
| Non-HLA immunogenetics in hematopoietic stem cell transplantation. | Dickinson AM et al. | β | 2005 | β |
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| Overdispersion of allele frequency differences between populations: implications for meta-analyses of genotypic disease associations. | Molony CM et al. | β | 2005 | β |
| Pharmacogenomics and the drug discovery pipeline: when should it be implemented? | Penny MA et al. | β | 2005 | β |
| Pharmacogenomics and therapeutic prospects in Alzheimer's disease. | Cacabelos R | β | 2005 | β |
| Plasminogen activator inhibitor-1 4G/5G polymorphism and risk of stroke: replicated findings in two nested case-control studies based on independent cohorts. | Wiklund PG et al. | β | 2005 | β |
| Polymorphism of the interleukin-1 receptor antagonist gene: a factor in susceptibility to rheumatoid arthritis in a Spanish population. | Carreira PE et al. | β | 2005 | β |
| Polymorphisms in the human surfactant protein-D (SFTPD) gene: strong evidence that serum levels of surfactant protein-D (SP-D) are genetically influenced. | Heidinger K et al. | β | 2005 | β |
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| Tests for the replication of an association between Egfr and natural variation in Drosophila melanogaster wing morphology. | Palsson A et al. | β | 2005 | β |
| The choice of a genetic model in the meta-analysis of molecular association studies. | Minelli C et al. | β | 2005 | β |
| The epidemiologic approach to pharmacogenomics. | Little J et al. | β | 2005 | β |
| The GABBR1 locus and the G1465A variant is not associated with temporal lobe epilepsy preceded by febrile seizures. | Ma S et al. | β | 2005 | β |
| The genetic epidemiology of neurodegenerative disease. | Bertram L et al. | β | 2005 | β |
| The need for a systematic approach to complex pathways in molecular epidemiology. | Thomas DC | β | 2005 | β |
| The Pro387Leu variant of protein tyrosine phosphatase-1B is not associated with diabetes mellitus type 2 in a German population. | Gouni-Berthold I et al. | β | 2005 | β |
| The suggestive association of eotaxin-2 and eotaxin-3 gene polymorphisms in Korean population with allergic rhinitis. | Chae SC et al. | β | 2005 | β |
| The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration. | Jim JJ et al. | β | 2005 | β |
| Using bioinformatics and genome analysis for new therapeutic interventions. | Mount DW et al. | β | 2005 | β |
| What can mendelian randomisation tell us about modifiable behavioural and environmental exposures? | Davey Smith G et al. | β | 2005 | β |
| What makes a good genetic association study? | Hattersley AT et al. | β | 2005 | β |
| Why most published research findings are false. | Ioannidis JP | β | 2005 | β |
| A family-based association study of congenital left-sided heart malformations and 5,10 methylenetetrahydrofolate reductase. | McBride KL et al. | β | 2004 | β |
| A functional polymorphism in the interleukin-1 receptor-1 gene is associated with increased risk of Helicobacter pylori infection but not with gastric cancer. | Hartland S et al. | β | 2004 | β |
| Alzheimer disease risk and genetic variation in ACE: a meta-analysis. | Elkins JS et al. | β | 2004 | β |
| Analysis of the CARD15 variants R702W, G908R and L1007fs in Italian IBD patients. | Giachino D et al. | β | 2004 | β |
| A polymorphism of the beta1-adrenergic receptor is associated with low extraversion. | Stein MB et al. | β | 2004 | β |
| Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. | Wacholder S et al. | β | 2004 | β |
| Association between chromogranin b gene polymorphisms and schizophrenia in the Japanese population. | Iijima Y et al. | β | 2004 | β |
| Association between the PPARalpha L162V polymorphism, plasma lipoprotein levels, and atherosclerotic disease in patients with diabetes mellitus type 2 and in nondiabetic controls. | Gouni-Berthold I et al. | β | 2004 | β |
| Association of APOE genotype with carotid atherosclerosis in men and women: the Framingham Heart Study. | Elosua R et al. | β | 2004 | β |
| Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients. | Teutsch SM et al. | β | 2004 | β |
| Association of interleukin-10 promoter polymorphisms with systemic lupus erythematosus. | Chong WP et al. | β | 2004 | β |
| Association of PDCD1 with susceptibility to systemic lupus erythematosus: evidence of population-specific effects. | Ferreiros-Vidal I et al. | β | 2004 | β |
| Association studies for finding cancer-susceptibility genetic variants. | Pharoah PD et al. | β | 2004 | β |
| Betting odds and genetic associations. | Thomas DC et al. | β | 2004 | β |
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| Cardiovascular genetics: are we there yet? | Sturm AC | β | 2004 | β |
| Challenges of implementing pharmacogenetics in the critical care environment. | Freeman BD et al. | β | 2004 | β |
| Chemokine receptor 5 and primary biliary cirrhosis: a two-centre genetic association study. | Baragiotta A et al. | β | 2004 | β |
| Clinical impact of cytokine gene polymorphisms in heart and lung transplantation. | Holweg CT et al. | β | 2004 | β |
| Clinical relevance of advances in genetics and pharmacogenetics of IBD. | Ahmad T et al. | β | 2004 | β |
| Coronary artery disease and the thrombospondin single nucleotide polymorphisms. | Stenina OI et al. | β | 2004 | β |
| DNA extraction yield is associated with several phenotypic characteristics: results from two large population surveys. | Alanne M et al. | β | 2004 | β |
| Effect of population stratification on case-control association studies. II. False-positive rates and their limiting behavior as number of subpopulations increases. | Gorroochurn P et al. | β | 2004 | β |
| Effects of TCN2 776C>G on vitamin B, folate, and total homocysteine levels in kidney transplant patients. | Winkelmayer WC et al. | β | 2004 | β |
| Endothelial NO synthase genotype and risk of preeclampsia: a multicenter case-control study. | Serrano NC et al. | β | 2004 | β |
| Establishment of genetic associations for complex diseases is independent of early study findings. | Trikalinos TA et al. | β | 2004 | β |
| Factor V Leiden and prothrombin gene G20210A mutations in Italian patients with BehΓ§et's disease and deep vein thrombosis. | Silingardi M et al. | β | 2004 | β |
| Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy. | Tan NC et al. | β | 2004 | β |
| Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies. | Wheeler JG et al. | β | 2004 | β |
| Fundamental role for HO-1 in the self-protection of renal allografts. | Baan C et al. | β | 2004 | β |
| Genetic association studies in epilepsy: "the truth is out there". | Tan NC et al. | β | 2004 | β |
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| Genetics of multiple sclerosis. | Dyment DA et al. | β | 2004 | β |
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| Issues in the reporting of epidemiological studies: a survey of recent practice. | Pocock SJ et al. | β | 2004 | β |
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| Lack of association of the vitamin D receptor gene with Graves' disease in UK Caucasians. | Collins JE et al. | β | 2004 | β |
| Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. | McCarthy JJ et al. | β | 2004 | β |
| Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whites. | Millikan RC et al. | β | 2004 | β |
| No association between interleukin-18 gene polymorphisms and haplotypes in Dutch sarcoidosis patients. | Janssen R et al. | β | 2004 | β |
| No genetic association between polymorphisms in the AMPA receptor subunit GluR4 gene (GRIA4) and schizophrenia in the Chinese population. | Guo S et al. | β | 2004 | β |
| Polymorphism of 5HT2A serotonin receptor gene is implicated in smoking addiction. | do Prado-Lima PA et al. | β | 2004 | β |
| Polymorphisms in the vitamin D receptor gene, ultraviolet radiation, and susceptibility to prostate cancer. | Bodiwala D et al. | β | 2004 | β |
| PTCH polymorphism is associated with the rate of increase in basal cell carcinoma numbers during follow-up: preliminary data on the influence of an exon 12-exon 23 haplotype. | Strange RC et al. | β | 2004 | β |
| Searching for cancer-associated gene polymorphisms: promises and obstacles. | Imyanitov EN et al. | β | 2004 | β |
| SNPs in cancer research and treatment. | Erichsen HC et al. | β | 2004 | β |
| Suggestive evidence of association of C-159T functional polymorphism of the CD14 gene with atopic asthma in northern and northwestern Indian populations. | Sharma M et al. | β | 2004 | β |
| Susceptibility to basal cell carcinoma: associations with PTCH polymorphisms. | Strange RC et al. | β | 2004 | β |
| Tall stories: the fundamental difficulties of genetic association studies. | Weedon MN et al. | β | 2004 | β |
| Tau gene and Parkinson's disease: a case-control study and meta-analysis. | Healy DG et al. | β | 2004 | β |
| TCR beta polymorphisms and multiple sclerosis. | Dyment DA et al. | β | 2004 | β |
| The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis. | Lawlor DA et al. | β | 2004 | β |
| The Clara cell10 adenine38guanine polymorphism and sarcoidosis susceptibility in Dutch and Japanese subjects. | Janssen R et al. | β | 2004 | β |
| The contribution of HLA genes to IBD susceptibility and phenotype. | Yap LM et al. | β | 2004 | β |
| The future of association studies: gene-based analysis and replication. | Neale BM et al. | β | 2004 | β |
| The genetics and pathophysiology of diabetes mellitus type II. | Jenkins AB et al. | β | 2004 | β |
| The genetics of cancer susceptibility: from mouse to man. | Ewart-Toland A et al. | β | 2004 | β |
| The potential role of genes in nonalcoholic fatty liver disease. | Day CP | β | 2004 | β |
| The prediction of disease risk in genomic medicine. | Hall WD et al. | β | 2004 | β |
| The thyroglobulin gene as the first thyroid-specific susceptibility gene for autoimmune thyroid disease. | Tomer Y et al. | β | 2004 | β |
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| TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study. | Gordon AC et al. | β | 2004 | β |
| Toll-like receptor polymorphisms and allergic disease: interpreting the evidence from genetic studies. | Yang IA et al. | β | 2004 | β |
| Type 1 diabetes is insulin -2221 MspI and CTLA-4 +49 A/G polymorphism dependent. | Haller K et al. | β | 2004 | β |
| Using germ-line genetic variation to investigate and treat cancer. | Savage SA et al. | β | 2004 | β |
| Clinical relevance of pharmacogenetics. | Becquemont L | β | 2003 | β |
| Commentary: Nature-nurture interplay in emotional disorders. | Rutter M | β | 2003 | β |
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| Familial clustering of abdominal aortic aneurysm--smoke signals, but no culprit genes. | Powell JT | β | 2003 | β |
| Finding hypertension genes: urge for more. | Deinum J | β | 2003 | β |
| Freely associating with chemokine receptor 2 polymorphisms and atherosclerosis. | Luft FC | β | 2003 | β |
| Genetics of susceptibility to human helminth infection. | Quinnell RJ | β | 2003 | β |
| HLA and HIV: modeling adaptation to moving targets. | Telenti A et al. | β | 2003 | β |
| In meningococcal disease 4G bad, 5G good. | Baines PB et al. | β | 2003 | β |
| 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? | Smith GD et al. | β | 2003 | β |
| Nonreplication in genetic association studies of obesity and diabetes research. | Redden DT et al. | β | 2003 | β |
| The application of functional genomics to Alzheimer's disease. | Cacabelos R | β | 2003 | β |
| The variable number of tandem repeat polymorphism in the P-selectin glycoprotein ligand-1 gene is not associated with coronary heart disease. | Bugert P et al. | β | 2003 | β |