Substance exposure in utero and developmental consequences in adolescence: a systematic review.
paper
Cited
Public
Unavailable
- Authors
- Irner, Tina Birk
- Year
- 2012
- Journal
- Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence
- PMID
- 22114955
- DOI
- 10.1080/09297049.2011.628309
BACKGROUND: The impacts of maternal substance use have been observed in both research and clinical experience. Several studies have shown that preschool children are at heightened risk of developing various cognitive, behavioral, and socioemotional difficulties. Most knowledge has been generated concerning alcohol consumption during pregnancy and the postnatal effects thereof. Less is known about substance use other than alcohol (for instance, opiates, marijuana, and cocaine) during pregnancy and the long-term developmental consequences. OBJECTIVE: The aims of this review are to identify relevant published data on adolescents who have been exposed in utero to alcohol and/or other substances and to examine developmental consequences across functions and mental health at this point in life. METHODS: PubMed, Embase, and PsychInfo were searched for publications during the period of 1980-2011 and titles and abstracts selected according to prespecified broad criteria. RESULTS: Twenty-five studies fulfilled all of the specific requirements and were included in this review. Most research covered prenatal alcohol exposure. Other substances, however, included cocaine, marijuana, opiates, and poly-substances. Results showed that prenatal exposure to alcohol has long-term cognitive, behavioral, social, and emotional developmental consequences depending on amount and timing of exposure in utero. Less evidence exists for long-term consequences of exposure in utero to other substances than alcohol. However, recent brain-imaging studies have provided important evidence of serious effects of other substance exposure on the developing brain and recent follow-up studies have found an association with deficits in language, attention, areas of cognitive performance and delinquent behavior in adolescence.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Meta-Analyses of Externalizing Disorders: Genetics or Prenatal Alcohol Exposure? | 2018 | 29063614 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Investigating Links Between Prenatal Cannabis Exposure and Brain Development Using Magnetic Resonance Imaging Techniques: A Narrative Review. | GonΓ§alves PD et al. | β | 2026 | β |
| Effects of integrated programs for substance-involved mothers on infant and child development outcomes: A systematic review and meta-analysis. | Barriault S et al. | β | 2025 | β |
| Neurodevelopmental challenges at age four following fetal exposure to maternal opioid maintenance treatment. | Kanervo MM et al. | β | 2025 | β |
| Prenatal substance exposure and infant neurodevelopment: a review of magnetic resonance imaging studies. | Shah L et al. | β | 2025 | β |
| Cumulative risk factors for injuries and poisoning requiring hospital care in youth with prenatal substance exposure: A longitudinal controlled cohort study. | Koponen AM et al. | β | 2024 | β |
| Interactions Between Genetic, Prenatal Substance Use, Puberty, and Parenting are Less Important for Understanding Adolescents' Internalizing, Externalizing, and Substance Use than Developmental Cascades in Multifactorial Models. | Marceau K et al. | β | 2024 | β |
| Investigating the associations between prenatal exposure to substances and intergenerational maltreatment and symptoms of psychopathology for adolescent girls from families with low income. | Warmingham J et al. | β | 2024 | β |
| Perinatal influences on academic achievement and the developing brain: a scoping systematic review. | Schneider D et al. | β | 2024 | β |
| Adverse childhood experiences and neurodevelopmental disorders among youth with and without prenatal substance exposure: A longitudinal matched register-based cohort study. | Koponen AM et al. | β | 2023 | β |
| A Comprehensive Review on Social Inequalities and Pregnancy Outcome-Identification of Relevant Pathways and Mechanisms. | Simoncic V et al. | β | 2022 | β |
| Criminalization of Care: Drug Testing Pregnant Patients. | McCabe K | β | 2022 | β |
| Evaluation of Brain Alterations and Behavior in Children With Low Levels of Prenatal Alcohol Exposure. | Long X et al. | β | 2022 | β |
| Long-term trends in adolescent alcohol, tobacco and cannabis use and emerging substance use issues in Aotearoa New Zealand. | Ball J et al. | β | 2022 | β |
| Mechanisms Underlying Cognitive Impairment Induced by Prenatal Alcohol Exposure. | Alhowail A | β | 2022 | β |
| Prenatal Substance Exposure and Child Maltreatment: A Systematic Review. | Austin AE et al. | β | 2022 | β |
| Developmental Cascades from Polygenic and Prenatal Substance Use to Adolescent Substance Use: Leveraging Severity and Directionality of Externalizing and Internalizing Problems to Understand Pubertal and Harsh Discipline-Related Risk. | Marceau K et al. | β | 2021 | β |
| Exploring Factors That Could Potentially Have Affected the First 1000 Days of Absent Learners in South Africa: A Qualitative Study. | van Zyl C et al. | β | 2021 | β |
| NCS Assessments of the Motor, Sensory, and Physical Health Domains. | Clark JE et al. | β | 2021 | β |
| Oral and written communication skills of adolescents with prenatal alcohol exposure (PAE) compared with those with no/low PAE: A systematic review. | Kippin NR et al. | β | 2021 | β |
| Cohort profile: ADEF Helsinki - a longitudinal register-based study on exposure to alcohol and drugs during foetal life. | Koponen AM et al. | β | 2020 | β |
| Developmental Pathways from Genetic, Prenatal, Parenting and Emotional/Behavioral Risk to Cortisol Reactivity and Adolescent Substance Use: A TRAILS Study. | Marceau K et al. | β | 2020 | β |
| Influence of Prenatal Methamphetamine Abuse on the Brain. | TomΓ‘Ε‘kovΓ‘ A et al. | β | 2020 | β |
| Nurse home visiting and prenatal substance use in a socioeconomically disadvantaged population in British Columbia: analysis of prenatal secondary outcomes in an ongoing randomized controlled trial. | Catherine NLA et al. | β | 2020 | β |
| Prenatal substance exposure, adverse childhood experiences and diagnosed mental and behavioral disorders - A longitudinal register-based matched cohort study in Finland. | Koponen AM et al. | β | 2020 | β |
| The blind men and the elephant: Systematic review of systematic reviews of cannabis use related health harms. | Campeny E et al. | β | 2020 | β |
| Case Reports: Multifaceted Experiences Treating Youth with Severe Obesity. | Schaller KE et al. | β | 2019 | β |
| Emotional Availability in Samples of Mothers at High Risk for Depression and With Substance Use Disorder. | Frigerio A et al. | β | 2019 | β |
| Prevalence of Fetal Alcohol Exposure by Analysis of Meconium Fatty Acid Ethyl Esters; A National Canadian Study. | Delano K et al. | β | 2019 | β |
| The contribution of environmental exposure to the etiology of autism spectrum disorder. | BΓΆlte S et al. | β | 2019 | β |
| Effects of prenatal marijuana exposure on neuropsychological outcomes in children aged 1-11Β years: A systematic review. | Sharapova SR et al. | β | 2018 | β |
| Meta-Analyses of Externalizing Disorders: Genetics or Prenatal Alcohol Exposure? | Wetherill L et al. | β | 2018 | β |
| Symptoms Associated With Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorders in School-Aged Children Prenatally Exposed to Substances. | Sandtorv LB et al. | β | 2018 | β |
| Care and supportive measures in school-aged children with prenatal substance exposure. | Sandtorv LB et al. | β | 2017 | β |
| Mental Health in School-Aged Children Prenatally Exposed to Alcohol and Other Substances. | Sandtorv LB et al. | β | 2017 | β |
| Using an adoption-biological family design to examine associations between maternal trauma, maternal depressive symptoms, and child internalizing and externalizing behaviors. | Grabow AP et al. | β | 2017 | β |
| A Novel Strategy for Attenuating Opioid Withdrawal in Neonates. | Santoro GC et al. | β | 2016 | β |
| The Perinatal Risk Index: Early Risks Experienced by Domestic Adoptees in the United States. | Marceau K et al. | β | 2016 | β |
| Identification of early developmental deficits in infants with prenatal heroin, methadone, and other opioid exposure. | Beckwith AM et al. | β | 2015 | β |
| Prenatal substance exposure and child self-regulation: Pathways to risk and protection. | Eiden RD et al. | β | 2015 | β |
| Prenatal Substance Use: Exploring Assumptions of Maternal Unfitness. | Terplan M et al. | β | 2015 | β |
| Prevalence and predictors of alcohol use during pregnancy: findings from international multicentre cohort studies. | O'Keeffe LM et al. | β | 2015 | β |
| Prevalence of substance abuse in pregnancy among Danish women. | Rausgaard NL et al. | β | 2015 | β |
| Psychopharmacologic treatment of children prenatally exposed to drugs of abuse. | Hulvershorn LA et al. | β | 2015 | β |
| Rat Ultrasonic Vocalizations and Behavioral Neuropharmacology: From the Screening of Drugs to the Study of Disease. | Simola N | β | 2015 | β |
| Child Behavior Problems: Role of Cocaine Use, Parenting and Child Exposure to Violence. | Veira Y et al. | β | 2014 | β |
| Drinking before and after pregnancy recognition among South African women: the moderating role of traumatic experiences. | Choi KW et al. | β | 2014 | β |
| Is alcohol binge drinking in early and late pregnancy associated with behavioural and emotional development at age 7 years? | Niclasen J et al. | β | 2014 | β |
| Maternal lifestyle and environmental risk factors for autism spectrum disorders. | Lyall K et al. | β | 2014 | β |
| Prenatal cocaine effects on brain structure in early infancy. | Grewen K et al. | β | 2014 | β |
| Prenatal cocaine exposure: the role of cumulative environmental risk and maternal harshness in the development of child internalizing behavior problems in kindergarten. | Eiden RD et al. | β | 2014 | β |
| Substance Use among Adolescent Mothers: A Review. | Chapman SL et al. | β | 2013 | β |