Gene-environment interaction.
paper
Cited
Public
Unavailable
- Authors
- Manuck, Stephen B; McCaffery, Jeanne M
- Year
- 2014
- Journal
- Annual review of psychology
- PMID
- 24405358
- DOI
- 10.1146/annurev-psych-010213-115100
With the advent of increasingly accessible technologies for typing genetic variation, studies of gene-environment (GΓE) interactions have proliferated in psychological research. Among the aims of such studies are testing developmental hypotheses and models of the etiology of behavioral disorders, defining boundaries of genetic and environmental influences, and identifying individuals most susceptible to risk exposures or most amenable to preventive and therapeutic interventions. This research also coincides with the emergence of unanticipated difficulties in detecting genetic variants of direct association with behavioral traits and disorders, which may be obscured if genetic effects are expressed only in predisposing environments. In this essay we consider these and other rationales for positing GΓE interactions, review conceptual models meant to inform GΓE interpretations from a psychological perspective, discuss points of common critique to which GΓE research is vulnerable, and address the role of the environment in GΓE interactions.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Genome-Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes. | Wang S et al. | β | 2026 | β |
| Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations. | Lee S et al. | β | 2026 | β |
| An Evolutionary Perspective on Dog Behavioral Genetics. | Lord KA et al. | β | 2025 | β |
| Childhood adversity and adolescent mental health: Examining cumulative and specificity effects across contexts and developmental timing. | Hardi FA et al. | β | 2025 | β |
| Differential susceptibility effects of the <i>5-HTTLPR</i> and <i>MAOA</i> genotypes on decision making under risk in the Iowa gambling task. | Rehn M et al. | β | 2025 | β |
| Dopaminergic Modulation of Conscientiousness: <i>DRD2</i> rs1799732 and Personality Traits in Elite Mixed Martial Arts Athletes. | Lachowicz M et al. | β | 2025 | β |
| Genetic Polymorphisms and Gene-Environment Interactions in Persistent Post-Stroke Depression. | Lan Y et al. | β | 2025 | β |
| High-Dimensional Gene-Environment Interaction Analysis. | Wu M et al. | β | 2025 | β |
| Incorporating additive genetic effects and linkage disequilibrium information to discover gene-environment interactions using BV-LDER-GE. | Dong Z et al. | β | 2025 | β |
| Interactive effects between lead-cadmium co-exposure and VEGFA gene polymorphisms on renal dysfunction: a gene-environment interaction study. | Deng Y et al. | β | 2025 | β |
| Not by Selection Alone: Expanding the Scope of Gene-Culture Coevolution. | Kasser SM et al. | β | 2025 | β |
| Parental income moderates the influence of genetic dispositions on political interest in adolescents. | Jungkunz S et al. | β | 2025 | β |
| Recalibrating differential gene expression by genetic dosage variance prioritizes functionally relevant genes. | Rentzsch P et al. | β | 2025 | β |
| Shedding Light on Antisocial Behavior Through Genetically Informed Research. | Pezzoli P et al. | β | 2025 | β |
| The effects of life experiences and polygenic risk for depression on the development of positive and negative cognitive biases across adolescence: The CogBIAS hypothesis. | Zavlis O et al. | β | 2025 | β |
| The Gut Mycobiome for Precision Medicine. | El Jaddaoui I et al. | β | 2025 | β |
| The impact of lifestyle factors on trajectories of cognitive subtypes in the older adult population. | Rodrigues EA et al. | β | 2025 | β |
| ERICH4 is not involved in the assembly and secretion of intestinal lipoproteins. | Visser A et al. | β | 2024 | β |
| Exploring the influence of the DRD2 gene on mathematical ability: perspectives of gene association and gene-environment interaction. | Yang Q et al. | β | 2024 | β |
| Gene-environment interaction: why genetic enhancement might never be distributed fairly. | Prince S | β | 2024 | β |
| Genetic and Environmental Influences on Sexual Orientation: Moderation by Childhood Gender Nonconformity and Early-Life Adversity. | Oginni OA et al. | β | 2024 | β |
| Interaction between Risk Single-Nucleotide Polymorphisms of Developmental Dyslexia and Parental Education on Reading Ability: Evidence for Differential Susceptibility Theory. | Yang Q et al. | β | 2024 | β |
| LDER-GE estimates phenotypic variance component of gene-environment interactions in human complex traits accurately with GE interaction summary statistics and full LD information. | Dong Z et al. | β | 2024 | β |
| Using the Infant Sibling-Design to Explore Associations Between Autism and ADHD Traits in Probands and Temperament in the Younger Siblings. | Andersson Konke L et al. | β | 2024 | β |
| A Longitudinal Analysis of Gene x Environment Interaction on Verbal Intelligence Across Adolescence and Early Adulthood. | Dong L et al. | β | 2023 | β |
| A multi-faceted role of dual-state dopamine signaling in working memory, attentional control, and intelligence. | Matzel LD et al. | β | 2023 | β |
| Association between genetic risk of alcohol consumption and alcohol-related morbidity and mortality under different alcohol policy conditions: Evidence from the Finnish alcohol price reduction of 2004. | Lahtinen H et al. | β | 2023 | β |
| Beyond orchids and dandelions: Susceptibility to environmental influences is not bimodal. | Zhang X et al. | β | 2023 | β |
| Cumulative genetic score of KIAA0319 affects reading ability in Chinese children: moderation by parental education and mediation by rapid automatized naming. | Zhao J et al. | β | 2023 | β |
| FunctanSNP: an R package for functional analysis of dense SNP data (with interactions). | Ren R et al. | β | 2023 | β |
| Gene-environment interactions and their impact on human health. | Virolainen SJ et al. | β | 2023 | β |
| Interaction between risk SNPs of Developmental Dyslexia and Parental Education on Reading Ability: Evidence for Differential-Susceptibility Theory | Yang Q et al. | β | 2023 | β |
| Loneliness during the Covid-19 pandemic in Germany: Impact of social factors and polygenic risk scores on interpersonal differences in loneliness and mental health. | von Werthern NM et al. | β | 2023 | β |
| The East Asian-specific LPL p.Ala288Thr (c.862Gβ>βA) missense variant exerts a mild effect on protein function. | Hu Y et al. | β | 2023 | β |
| The interplay of family history of depression and early trauma: associations with lifetime and current depression in the German national cohort (NAKO). | Streit F et al. | β | 2023 | β |
| A Cross-validated Ensemble Approach to Robust Hypothesis Testing of Continuous Nonlinear Interactions: Application to Nutrition-Environment Studies. | Liu JZ et al. | β | 2022 | β |
| Association of hypertension with helicobacter pylori: A systematic review and metaβanalysis. | Fang Y et al. | β | 2022 | β |
| Association of Polymorphism within the Putative miRNA Target Site in the 3'UTR Region of the <i>DRD2</i> Gene with Neuroticism in Patients with Substance Use Disorder. | BoroΕ A et al. | β | 2022 | β |
| Associations of genetic risk, BMI trajectories, and the risk of non-small cell lung cancer: a population-based cohort study. | You D et al. | β | 2022 | β |
| Attachment Style Moderates Polygenic Risk forΒ Incident Posttraumatic Stress in U.S. Military Veterans: A 7-Year, Nationally Representative, Prospective Cohort Study. | Tamman AJF et al. | β | 2022 | β |
| Developmental Language Disorder and Psychopathology: Disentangling Shared Genetic and Environmental Influences. | Toseeb U et al. | β | 2022 | β |
| From Genome-Wide to Environment-Wide: Capturing the Environome. | von Stumm S et al. | β | 2022 | β |
| Gene-environment interactions explain a substantial portion of variability of common neuropsychiatric disorders. | Zhang H et al. | β | 2022 | β |
| Increased depressive and anxiety symptoms in non-heterosexual individuals: Moderation by childhood factors using a twin design. | Oginni OA et al. | β | 2022 | β |
| Longitudinal Influences of DRD4 Polymorphism and Early Maternal Caregiving on Personality Development and Problem Behavior in Middle Childhood and Adolescence. | Zimmermann P et al. | β | 2022 | β |
| On the Opportunities and Risks of Examining the Genetics of Entrepreneurship. | Heller B et al. | β | 2022 | β |
| The early-life exposome modulates the effect of polymorphic inversions on DNA methylation. | Carreras-Gallo N et al. | β | 2022 | β |
| The role of parenting in the intergenerational transmission of executive functioning: A genetically informed approach. | Tomlinson RC et al. | β | 2022 | β |
| Three phases of Gene Γ Environment interaction research: Theoretical assumptions underlying gene selection. | Zhang X et al. | β | 2022 | β |
| Brain structure is linked to the association between family environment and behavioral problems in children in the ABCD study. | Gong W et al. | β | 2021 | β |
| Differential moderation effects of ApoE and 5-HTTLPR genotypes on social vulnerability in predicting mortality among community-dwelling middle-aged and older adults: a nationwide population-based study. | Liu HY et al. | β | 2021 | β |
| Does urbanicity modify the relationship between a polygenic risk score for depression and mental health symptoms? Cross-sectional evidence from the observational HUNT Study in Norway. | Sund ER et al. | β | 2021 | β |
| Evaluate the effects of serum urate level on bone mineral density: a genome-wide gene-environment interaction analysis in UK Biobank cohort. | Yao Y et al. | β | 2021 | β |
| miRNA: local guardians of presynaptic function in plasticity and disease. | Woods BJ et al. | β | 2021 | β |
| "Reports of My Death Were Greatly Exaggerated": Behavior Genetics in the Postgenomic Era. | Harden KP | β | 2021 | β |
| Systematic Review and Meta-analysis of Genetically Informed Research: Associations Between Parent Anxiety and Offspring Internalizing Problems. | Ahmadzadeh YI et al. | β | 2021 | β |
| An Experimental Examination of Demand-Side Preferences for Female and Male National Leaders. | Murray GR et al. | β | 2020 | β |
| A Regularization-Based Adaptive Test for High-Dimensional Generalized Linear Models. | Wu C et al. | β | 2020 | β |
| Association and interaction of the FTO rs1421085 with overweight/obesity in a sample of Pakistani individuals. | Rana S et al. | β | 2020 | β |
| Cognitive ability and education: How behavioural genetic research has advanced our knowledge and understanding of their association. | Malanchini M et al. | β | 2020 | β |
| Evaluation of a Longitudinal Family Stress Model in a Population-Based Cohort. | Gard AM et al. | β | 2020 | β |
| Genetic risk of obesity as a modifier of associations between neighbourhood environment and body mass index: an observational study of 335 046 UK Biobank participants. | Mason KE et al. | β | 2020 | β |
| Helicobacter pylori infection and the prevalence of hypertension in Chinese adults: The Dongfeng-Tongji cohort. | Xiong X et al. | β | 2020 | β |
| Integrating Genome-Wide Association Studies and Gene Expression Profiles With Chemical-Genes Interaction Networks to Identify Chemicals Associated With Colorectal Cancer. | Tan X et al. | β | 2020 | β |
| Interpersonal childhood adversity and stress generation in adolescence: Moderation by HPA axis multilocus genetic variation. | Huang M et al. | β | 2020 | β |
| Ion Channel Functions in Early Brain Development. | Smith RS et al. | β | 2020 | β |
| Ion Channels Involvement in Neurodevelopmental Disorders. | D'Adamo MC et al. | β | 2020 | β |
| Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder. | Chen LM et al. | β | 2020 | β |
| Messaging in Biological Psychiatry: Misrepresentations, Their Causes, and Potential Consequences. | Dumas-Mallet E et al. | β | 2020 | β |
| Oxytocin receptor gene polymorphisms moderate the relationship between job stress and general trust in Chinese Han university teachers. | Fang Y et al. | β | 2020 | β |
| Parental warmth interacts with several genes to affect executive function components: a genome-wide environment interaction study. | Chen C et al. | β | 2020 | β |
| Precision health: a primer for physiotherapists. | Dickson C et al. | β | 2020 | β |
| The social and genetic inheritance of educational attainment: Genes, parental education, and educational expansion. | Lin MJ | β | 2020 | β |
| Vulnerable Boys: Short-term and Long-term Gender Differences in the Impacts of Adolescent Disadvantage. | Lei Z et al. | β | 2020 | β |
| Work Stress and General Trust: The Mediating Effect of Depression and the Moderating Effect of the OXTR Gene rs53576. | Yu X et al. | β | 2020 | β |
| Applying Mental Model Methods to Characterize Understanding of Gene-Environment Influences: The Case of Podoconiosis in Ethiopia. | Allen CG et al. | β | 2019 | β |
| Born this way? A review of neurobiological and environmental evidence for the etiology of psychopathy. | Frazier A et al. | β | 2019 | β |
| Correlations between social dominance orientation and political attitudes reflect common genetic underpinnings. | KleppestΓΈ TH et al. | β | 2019 | β |
| Genetic and Environmental Influences on Achievement Goal Orientations Shift with Age. | Zheng A et al. | β | 2019 | β |
| Genetic Contributions to Loneliness and Their Relevance to the Evolutionary Theory of Loneliness. | Spithoven AWM et al. | β | 2019 | β |
| Genetic influences on antisocial behavior: recent advances and future directions. | Gard AM et al. | β | 2019 | β |
| Genotype-covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model. | Ni G et al. | β | 2019 | β |
| Individual differences in object recognition. | Richler JJ et al. | β | 2019 | β |
| Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems. | Choi D et al. | β | 2019 | β |
| Interpreting Behavior Genetic Models: Seven Developmental Processes to Understand. | Briley DA et al. | β | 2019 | β |
| Molecular Origins of Complex Heritability in Natural Genotype-to-Phenotype Relationships. | Jakobson CM et al. | β | 2019 | β |
| Neighborhood alcohol outlet density and genetic influences on alcohol use: evidence for gene-environment interaction. | Slutske WS et al. | β | 2019 | β |
| Neighborhood density of alcohol outlets moderates genetic and environmental influences on alcohol problems. | Slutske WS et al. | β | 2019 | β |
| Phenotypic Switching Resulting From Developmental Plasticity: Fixed or Reversible? | Burggren WW | β | 2019 | β |
| Polygenic approaches to detect gene-environment interactions when external information is unavailable. | Lin WY et al. | β | 2019 | β |
| The interaction between monoamine oxidase A (<i>MAOA</i>) and childhood maltreatment as a predictor of personality pathology in females: Emotional reactivity as a potential mediating mechanism. | Byrd AL et al. | β | 2019 | β |
| The nature and nurture of social development: The role of 5-HTTLPR and gene-parenting interactions. | Caplan B et al. | β | 2019 | β |
| Birth weight interacts with a functional variant of the oxytocin receptor gene (OXTR) to predict executive functioning in children. | Wade M et al. | β | 2018 | β |
| Critical Issues in the Inclusion of Genetic and Epigenetic Information in Prevention and Intervention Trials. | Latendresse SJ et al. | β | 2018 | β |
| Dopamine genes are linked to Extraversion and Neuroticism personality traits, but only in demanding climates. | Fischer R et al. | β | 2018 | β |
| Education, Smoking, and Cohort Change: Forwarding a Multidimensional Theory of the Environmental Moderation of Genetic Effects. | Wedow R et al. | β | 2018 | β |
| Gene-environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions. | Nilsson KW et al. | β | 2018 | β |
| Genetic variation in the developmental regulation of cortical avpr1a among prairie voles. | Okhovat M et al. | β | 2018 | β |
| Individual biological sensitivity to environmental influences: testing the differential susceptibility properties of the 5HTTLPR polymorphism in relation to depressive symptoms and delinquency in two adolescent general samples. | Γ slund C et al. | β | 2018 | β |
| Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review. | Misiak B et al. | β | 2018 | β |
| Nature, nurture, and capital punishment: How evidence of a genetic-environment interaction, future dangerousness, and deliberation affect sentencing decisions. | Gordon N et al. | β | 2018 | β |
| Pharmacogenomics and Psychiatric Clinical Care. | Amato RJ et al. | β | 2018 | β |
| Stress-Related Biosocial Mechanisms of Discrimination and African American Health Inequities. | Goosby BJ et al. | β | 2018 | β |
| The Moderating Effect of the Ankyrin Repeat and Kinase Domain Containing One Gene on the Association of Family Environment with Longitudinal Executive Function following Traumatic Brain Injury in Early Childhood: A Preliminary Study. | Smith-Paine J et al. | β | 2018 | β |
| The paradox of intelligence: Heritability and malleability coexist in hidden gene-environment interplay. | Sauce B et al. | β | 2018 | β |
| Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci. | Stender S et al. | β | 2017 | β |
| Biometric Modeling of Gene-Environment Interplay: The Intersection of Theory and Method and Applications for Social Inequality. | South SC et al. | β | 2017 | β |
| Gene-environment interplay in the context of romantic relationships. | Whisman MA et al. | β | 2017 | β |
| Gene-Environment Interplay in the Context of Romantic Relationships. | Whisman MA et al. | β | 2017 | β |
| Introducing the Microbiome into Precision Medicine. | Kuntz TM et al. | β | 2017 | β |
| Is level of prematurity a risk/plasticity factor at three years of age? | Hadfield K et al. | β | 2017 | β |
| Mini-Review: The Contribution of Intermediate Phenotypes to GxE Effects on Disorders of Body Composition in the New OMICS Era. | Nava-Gonzalez EJ et al. | β | 2017 | β |
| Mortality selection in a genetic sample and implications for association studies. | Domingue BW et al. | β | 2017 | β |
| Plastic and immobile: Unequal intergenerational mobility by genetic sensitivity score within sibling pairs. | Rauscher E | β | 2017 | β |
| The Drosophila <i>foraging</i> gene human orthologue <i>PRKG1</i> predicts individual differences in the effects of early adversity on maternal sensitivity. | Sokolowski HM et al. | β | 2017 | β |
| The Impact of Peer Substance Use and Polygenic Risk on Trajectories of Heavy Episodic Drinking Across Adolescence and Emerging Adulthood. | Li JJ et al. | β | 2017 | β |
| Why death haunts black lives. | Massey DS | β | 2017 | β |
| 5-HTTLPR polymorphism is linked to neural mechanisms of selective attention in preschoolers from lower socioeconomic status backgrounds. | Isbell E et al. | β | 2016 | β |
| Beyond main effects of gene-sets: harsh parenting moderates the association between a dopamine gene-set and child externalizing behavior. | Windhorst DA et al. | β | 2016 | β |
| Charting the landscape of priority problems in psychiatry, part 2: pathogenesis and aetiology. | Stephan KE et al. | β | 2016 | β |
| Culture as a mediator of gene-environment interaction: Cultural consonance, childhood adversity, a 2A serotonin receptor polymorphism, and depression in urban Brazil. | Dressler WW et al. | β | 2016 | β |
| Differential Susceptibility of the Developing Brain to Contextual Adversity and Stress. | Boyce WT | β | 2016 | β |
| Gender and genetic contributions to weight identity among adolescents and young adults in the U.S. | Wedow R et al. | β | 2016 | β |
| Gene-gene and gene-environment interactions on risk of male infertility: Focus on the metabolites. | Hu W et al. | β | 2016 | β |
| Meta-analysis of the serotonin transporter promoter variant (5-HTTLPR) in relation to adverse environment and antisocial behavior. | Tielbeek JJ et al. | β | 2016 | β |
| Methodological Problems on the Way to Integrative Human Neuroscience. | Kotchoubey B et al. | β | 2016 | β |
| Models of Intergenerational and Transgenerational Transmission of Risk for Psychopathology in Mice. | Klengel T et al. | β | 2016 | β |
| The interaction of cultural consonance and a polymorphism in the 2A serotonin receptor in relation to depression in Brazil: failure to replicate previous findings. | Dressler WW et al. | β | 2016 | β |
| What Is a Genome? | Goldman AD et al. | β | 2016 | β |
| A Culture-Behavior-Brain Loop Model of Human Development. | Han S et al. | β | 2015 | β |
| Adolescent Loneliness and the Interaction between the Serotonin Transporter Gene (5-HTTLPR) and Parental Support: A Replication Study. | Spithoven AW et al. | β | 2015 | β |
| BDNF Val66Met, stress, and positive mothering: Differential susceptibility model of adolescent trait anxiety. | Chen J et al. | β | 2015 | β |
| CHALLENGES FOR IMPLEMENTING A PTSD PREVENTIVE GENOMIC SEQUENCING PROGRAM IN THE U.S. MILITARY. | LΓ‘zaro-MuΓ±oz G et al. | β | 2015 | β |
| Developmental interplay between children's biobehavioral risk and the parenting environment from toddler to early school age: Prediction of socialization outcomes in preadolescence. | Kochanska G et al. | β | 2015 | β |
| Developmental psychopathology in an era of molecular genetics and neuroimaging: A developmental neurogenetics approach. | Hyde LW | β | 2015 | β |
| FKBP5 allele-specific epigenetic modification in gene by environment interaction. | Klengel T et al. | β | 2015 | β |
| Gene-environment interaction between the oxytocin receptor (OXTR) gene and parenting behaviour on children's theory of mind. | Wade M et al. | β | 2015 | β |
| Genetic differential susceptibility on trial: meta-analytic support from randomized controlled experiments. | van Ijzendoorn MH et al. | β | 2015 | β |
| Hypothesis-driven research for G Γ E interactions: the relationship between oxytocin, parental divorce during adolescence, and depression in young adulthood. | Windle M et al. | β | 2015 | β |
| Local area disadvantage and gambling involvement and disorder: Evidence for gene-environment correlation and interaction. | Slutske WS et al. | β | 2015 | β |
| Neurocognitive Late Effects of Chemotherapy in Survivors of Acute Lymphoblastic Leukemia: Focus on Methotrexate. | van der Plas E et al. | β | 2015 | β |
| Neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia treated on contemporary treatment protocols: A systematic review. | Cheung YT et al. | β | 2015 | β |
| Psychiatric symptoms in adolescents: FKBP5 genotype--early life adversity interaction effects. | Comasco E et al. | β | 2015 | β |
| Reply to: the liptak-stouffer test for meta-analyses. | Byrd AL et al. | β | 2015 | β |
| The hidden efficacy of interventions: geneΓenvironment experiments from a differential susceptibility perspective. | Bakermans-Kranenburg MJ et al. | β | 2015 | β |
| Commentary: G Γ E in child psychiatry and psychology: a broadening of the scope of enquiry as prompted by MunafΓ² et al. (2014). | Rutter M | β | 2014 | β |
| Editorial: Translational genetics of child psychopathology: a distant dream? | Maughan B et al. | β | 2014 | β |
| Emotion regulation moderates the risk associated with the 5-HTT gene and stress in children. | Ford BQ et al. | β | 2014 | β |
| Gene-environment interaction research in psychiatric epidemiology: a framework and implications for study design. | Belsky DW et al. | β | 2014 | β |