Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting.
paper
Cited
Public
Unavailable
- Authors
- Kersten, S; Seydoux, J; Peters, J M; Gonzalez, F J; Desvergne, B; Wahli, W
- Year
- 1999
- Journal
- The Journal of clinical investigation
- PMID
- 10359558
- DOI
- 10.1172/JCI6223
- PMCID
- PMC408372
Prolonged deprivation of food induces dramatic changes in mammalian metabolism, including the release of large amounts of fatty acids from the adipose tissue, followed by their oxidation in the liver. The nuclear receptor known as peroxisome proliferator-activated receptor alpha (PPARalpha) was found to play a role in regulating mitochondrial and peroxisomal fatty acid oxidation, suggesting that PPARalpha may be involved in the transcriptional response to fasting. To investigate this possibility, PPARalpha-null mice were subjected to a high fat diet or to fasting, and their responses were compared with those of wild-type mice. PPARalpha-null mice chronically fed a high fat diet showed a massive accumulation of lipid in their livers. A similar phenotype was noted in PPARalpha-null mice fasted for 24 hours, who also displayed severe hypoglycemia, hypoketonemia, hypothermia, and elevated plasma free fatty acid levels, indicating a dramatic inhibition of fatty acid uptake and oxidation. It is shown that to accommodate the increased requirement for hepatic fatty acid oxidation, PPARalpha mRNA is induced during fasting in wild-type mice. The data indicate that PPARalpha plays a pivotal role in the management of energy stores during fasting. By modulating gene expression, PPARalpha stimulates hepatic fatty acid oxidation to supply substrates that can be metabolized by other tissues.
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| Species Differences between Mouse and Human PPARΞ± in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARΞ± Agonist in Mice. | Foreman JE et al. | β | 2021 | β |
| Systems-wide effects of short-term feed deprivation in obese mice. | Andersen D et al. | β | 2021 | β |
| The alleviating effect of sphingosine kinases 2 inhibitor K145 on nonalcoholic fatty liver. | Shi Y et al. | β | 2021 | β |
| The Anti-Inflammatory Properties of Phytochemicals and Their Effects on Epigenetic Mechanisms Involved in TLR4/NF-ΞΊB-Mediated Inflammation. | Saleh HA et al. | β | 2021 | β |
| The Hepatic Monocarboxylate Transporter 1 (MCT1) Contributes to the Regulation of Food Anticipation in Mice. | Martini T et al. | β | 2021 | β |
| The long and winding road of cardiomyocyte maturation. | Maroli G et al. | β | 2021 | β |
| The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD. | Hong T et al. | β | 2021 | β |
| The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism. | Geisler CE et al. | β | 2021 | β |
| The transcription factors CREBH, PPARa, and FOXO1 as critical hepatic mediators of diet-induced metabolic dysregulation. | Yang Z et al. | β | 2021 | β |
| Transcriptional Regulation of Metabolic Pathways via Lipid-Sensing Nuclear Receptors PPARs, FXR, and LXR in NASH. | Cariello M et al. | β | 2021 | β |
| Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics and Oncogenesis-Part 1: Acetyl-CoA, Acetogenesis and Acyl-CoA Short-Chain Synthetases. | Moffett JR et al. | β | 2020 | β |
| Agonist binding directs dynamic competition among nuclear receptors for heterodimerization with retinoid X receptor. | Fadel L et al. | β | 2020 | β |
| Antiepileptic Drug-Activated Constitutive Androstane Receptor Inhibits Peroxisome Proliferator-Activated Receptor <i>Ξ±</i> and Peroxisome Proliferator-Activated Receptor <i>Ξ³</i> Coactivator 1<i>Ξ±</i>-Dependent Gene Expression to Increase Blood Triglyceride Levels. | Shizu R et al. | β | 2020 | β |
| Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma Ξ²-Hydroxybutyrate. | Hinds TD et al. | β | 2020 | β |
| CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic Potential. | Schlaepfer IR et al. | β | 2020 | β |
| CR reprograms acetyl-CoA metabolism and induces long-chain acyl-CoA dehydrogenase and CrAT expression. | Mezhnina V et al. | β | 2020 | β |
| Dietary natural products as epigenetic modifiers in aging-associated inflammation and disease. | Evans LW et al. | β | 2020 | β |
| Differentially Expressed Genes and Their Clinical Significance in Ischaemic Stroke: An In-Silico Study. | Appunni S et al. | β | 2020 | β |
| Fatty Acid Synthase: An Emerging Target in Cancer. | Fhu CW et al. | β | 2020 | β |
| Flavonoids-mediated SIRT1 signaling activation in hepatic disorders. | Sayed AM et al. | β | 2020 | β |
| Functions of mammalian SIRT4 in cellular metabolism and research progress in human cancer. | Wang C et al. | β | 2020 | β |
| Grape seed proanthocyanidin extract ameliorates hepatic lipid accumulation and inflammation in grass carp (Ctenopharyngodon idella). | Lu RH et al. | β | 2020 | β |
| Hepatic PPARΞ± function and lipid metabolic pathways are dysregulated in polymicrobial sepsis. | Van Wyngene L et al. | β | 2020 | β |
| Hepatocyte-specific deletion of PparΞ± promotes NAFLD in the context of obesity. | RΓ©gnier M et al. | β | 2020 | β |
| High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARΞ±: a new model for steatohepatitis-associated fibrosis. | Chen X et al. | β | 2020 | β |
| Hypoketotic hypoglycemia in citrin deficiency: a case report. | Wada Y et al. | β | 2020 | β |
| Impaired Neonatal Immunity and Infection Resistance Following Fetal Growth Restriction in Preterm Pigs. | BΓ¦k O et al. | β | 2020 | β |
| Inhibition of Lipid Accumulation in Skeletal Muscle and Liver Cells: A Protective Mechanism of Bilirubin Against Diabetes Mellitus Type 2. | Hana CA et al. | β | 2020 | β |
| Intrauterine Inflammation Alters the Transcriptome and Metabolome in Placenta. | Lien YC et al. | β | 2020 | β |
| Investigating the Role of PPARΞ²/Ξ΄ in Retinal Vascular Remodeling Using <i>PparΞ²</i>/<i>Ξ΄</i>-Deficient Mice. | Ho SY et al. | β | 2020 | β |
| iTAG-RNA Isolates Cell-Specific Transcriptional Responses to Environmental Stimuli and Identifies an RNA-Based Endocrine Axis. | Darr J et al. | β | 2020 | β |
| Liraglutide Alleviates Hepatic Steatosis and Liver Injury in T2MD Rats via a GLP-1R Dependent AMPK Pathway. | Zhou R et al. | β | 2020 | β |
| Long-chain fatty acid oxidation disorders and current management strategies. | Vockley J | β | 2020 | β |
| Maintenance of liver glycogen during long-term fasting preserves energy state in mice. | LΓ³pez-Soldado I et al. | β | 2020 | β |
| Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorononanoic acid (PFNA) increase triglyceride levels and decrease cholesterogenic gene expression in human HepaRG liver cells. | Louisse J et al. | β | 2020 | β |
| Peroxisomal proliferator-activated receptor Ξ±-b deficiency induces the reprogramming of nutrient metabolism in zebrafish. | Li LY et al. | β | 2020 | β |
| Peroxisome Proliferator-Activated Receptors and Caloric Restriction-Common Pathways Affecting Metabolism, Health, and Longevity. | Duszka K et al. | β | 2020 | β |
| Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease. | Fougerat A et al. | β | 2020 | β |
| Peroxisome Proliferator-Activated Receptors as Molecular Links between Caloric Restriction and Circadian Rhythm. | Duszka K et al. | β | 2020 | β |
| PKA functions in metabolism and resistance to obesity: lessons from mouse and human studies. | London E et al. | β | 2020 | β |
| PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice. | Wang Y et al. | β | 2020 | β |
| PPAR-Ξ± Deletion Attenuates Cisplatin Nephrotoxicity by Modulating Renal Organic Transporters MATE-1 and OCT-2. | Freitas-Lima LC et al. | β | 2020 | β |
| PPARΞ±/Ξ² Activation Alleviates Age-Associated Renal Fibrosis in Sprague Dawley Rats. | Chung KW et al. | β | 2020 | β |
| Probing metabolic memory in the hepatic response to fasting. | Defour M et al. | β | 2020 | β |
| Reappraisal of the optimal fasting time for insulin tolerance tests in mice. | Carper D et al. | β | 2020 | β |
| Regulation of hepatokine gene expression in response to fasting and feeding: Influence of PPAR-Ξ± and insulin-dependent signalling in hepatocytes. | Smati S et al. | β | 2020 | β |
| Regulation of type 3 deiodinase in rodent liver and adipose tissue during fasting. | de Vries EM et al. | β | 2020 | β |
| Regulatory Role of Retinoic Acid in Male Pregnancy of the Seahorse. | Li C et al. | β | 2020 | β |
| Shared PPARΞ±/Ξ³ Target Genes Regulate Brown Adipocyte Thermogenic Function. | Shen Y et al. | β | 2020 | β |
| Sleep profile during fasting in PPAR-alpha knockout mice. | Kondo Y et al. | β | 2020 | β |
| Swim therapy-induced tissue specific metabolic responses in male rats. | Moustafa A et al. | β | 2020 | β |
| Targeting PPAR ligands as possible approaches for metabolic reprogramming of T cells in cancer immunotherapy. | Bahrambeigi S et al. | β | 2020 | β |
| The branched-chain amino acids valine and leucine have differential effects on hepatic lipid metabolism. | Bishop CA et al. | β | 2020 | β |
| The interplay between non-esterified fatty acids and bovine peroxisome proliferator-activated receptors: results of an <i>in vitro</i> hybrid approach. | Busato S et al. | β | 2020 | β |
| The metabolic basis of nonalcoholic steatohepatitis. | Chakravarthy MV et al. | β | 2020 | β |
| Time-Restricted Feeding Reduces the Detrimental Effects of a High-Fat Diet, Possibly by Modulating the Circadian Rhythm of Hepatic Lipid Metabolism and Gut Microbiota. | Ye Y et al. | β | 2020 | β |
| Transcriptome responses in blood reveal distinct biological pathways associated with arsenic exposure through drinking water in rural settings of Punjab, Pakistan. | Rehman MYA et al. | β | 2020 | β |
| Unravelling the changes during induced vitellogenesis in female European eel through RNA-Seq: What happens to the liver? | Bertolini F et al. | β | 2020 | β |
| Acetate Affects the Process of Lipid Metabolism in Rabbit Liver, Skeletal Muscle and Adipose Tissue. | Liu L et al. | β | 2019 | β |
| Adipose-derived autotaxin regulates inflammation and steatosis associated with diet-induced obesity. | Brandon JA et al. | β | 2019 | β |
| Adrenoceptor-related decrease in serum triglycerides is independent of PPARΞ± activation. | Konstandi M et al. | β | 2019 | β |
| A novel preventive mechanism of gentamicin-induced nephrotoxicity by atorvastatin. | Lee MC et al. | β | 2019 | β |
| A review of the studies on food-derived factors which regulate energy metabolism via the modulation of lipid-sensing nuclear receptors. | Goto T | β | 2019 | β |
| BabaoDan attenuates high-fat diet-induced non-alcoholic fatty liver disease via activation of AMPK signaling. | Sheng D et al. | β | 2019 | β |
| Capsaicin Targets Lipogenesis in HepG2 Cells Through AMPK Activation, AKT Inhibition and PPARs Regulation. | Bort A et al. | β | 2019 | β |
| Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet. | Quagliarini F et al. | β | 2019 | β |
| Clocking In, Working Out: Circadian Regulation of Exercise Physiology. | Duglan D et al. | β | 2019 | β |
| Concomitant PPARΞ± and FXR Activation as a Putative Mechanism of NASH Improvement after Gastric Bypass Surgery: a GEO Datasets Analysis. | Mazzini GS et al. | β | 2019 | β |
| Control strategies in systemic metabolism. | Ye J et al. | β | 2019 | β |
| CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model. | Wang K et al. | β | 2019 | β |
| Differential Recovery Speed of Activity and Metabolic Rhythms in Rats After an Experimental Protocol of Shift-Work. | Saderi N et al. | β | 2019 | β |
| Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis. | Sommars MA et al. | β | 2019 | β |
| Effects of Paramylon Extracted from <i>Euglena gracilis</i> EOD-1 on Parameters Related to Metabolic Syndrome in Diet-Induced Obese Mice. | Aoe S et al. | β | 2019 | β |
| Environmental contaminants modulate the transcriptional activity of polar bear (Ursus maritimus) and human peroxisome proliferator-activated receptor alpha (PPARA). | Routti H et al. | β | 2019 | β |
| Evidence from 3-month-old infants shows that a combination of postnatal feeding and exposures in utero shape lipid metabolism. | Furse S et al. | β | 2019 | β |
| Fasting of male mice - Effects of time point of initiation and duration on clinical chemistry parameters and animal welfare. | Jensen TL et al. | β | 2019 | β |
| Fatty Acid Oxidation Promotes Cardiomyocyte Proliferation Rate but Does Not Change Cardiomyocyte Number in Infant Mice. | Cao T et al. | β | 2019 | β |
| Glycogen Synthase Kinase-3Ξ± Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. | Nakamura M et al. | β | 2019 | β |
| Going Back to the Biology of FGF21: New Insights. | Lewis JE et al. | β | 2019 | β |
| Hepatic monoacylglycerol acyltransferase 1 is induced by prolonged food deprivation to modulate the hepatic fasting response. | Lutkewitte AJ et al. | β | 2019 | β |
| Hepatic PPARΞ± is critical in the metabolic adaptation to sepsis. | Paumelle R et al. | β | 2019 | β |
| Hepatic transcriptome analysis from HFD-fed mice defines a long noncoding RNA regulating cellular cholesterol levels. | Chen Q et al. | β | 2019 | β |
| Hepatocyte-specific Sirt6 deficiency impairs ketogenesis. | Chen L et al. | β | 2019 | β |
| Identification of a natural beige adipose depot in mice. | Chan M et al. | β | 2019 | β |
| Impact of PPAR-Alpha Polymorphisms-The Case of Metabolic Disorders and Atherosclerosis. | Ruscica M et al. | β | 2019 | β |
| Insect Meal as Alternative Protein Source Exerts Pronounced Lipid-Lowering Effects in Hyperlipidemic Obese Zucker Rats. | Gessner DK et al. | β | 2019 | β |
| Intermittent fasting improves metabolic flexibility in short-term high-fat diet-fed mice. | Dedual MA et al. | β | 2019 | β |
| Ketogenic Diet: A New Light Shining on Old but Gold Biochemistry. | Longo R et al. | β | 2019 | β |
| Loss of hepatic PPARΞ± promotes inflammation and serum hyperlipidemia in diet-induced obesity. | Stec DE et al. | β | 2019 | β |
| Metabolic alterations associated with maternal undernutrition during the first half of gestation lead to a diabetogenic state in the rat. | Limones M et al. | β | 2019 | β |
| Mitochondrial Involvement in the Adaptive Response to Chronic Exposure to Environmental Pollutants and High-Fat Feeding in a Rat Liver and Testis. | Migliaccio V et al. | β | 2019 | β |
| Mito-Nuclear Communication in Hepatocellular Carcinoma Metabolic Rewiring. | Mello T et al. | β | 2019 | β |
| Morin reduces inflammatory responses and alleviates lipid accumulation in hepatocytes. | Wu L et al. | β | 2019 | β |
| Mouse trefoil factor 3 ameliorated high-fat-diet-induced hepatic steatosis via increasing peroxisome proliferator-activated receptor-Ξ±-mediated fatty acid oxidation. | Wu X et al. | β | 2019 | β |
| Nutritional Regulation of Gene Expression: Carbohydrate-, Fat- and Amino Acid-Dependent Modulation of Transcriptional Activity. | Haro D et al. | β | 2019 | β |
| p21cip1/waf1 Coordinate Autophagy, Proliferation and Apoptosis in Response to Metabolic Stress. | Manu KA et al. | β | 2019 | β |
| PAR2 controls cholesterol homeostasis and lipid metabolism in nonalcoholic fatty liver disease. | Rana R et al. | β | 2019 | β |
| PPARΞ± contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis. | Iwaki T et al. | β | 2019 | β |
| PPARΞ±-Mediated Positive-Feedback Loop Contributes to Cold Exposure Memory. | Alfaqaan S et al. | β | 2019 | β |
| Preterm Lung Exhibits Distinct Spatiotemporal Proteome Expression at Initiation of Lung Injury. | Pereira-Fantini PM et al. | β | 2019 | β |
| Raptor genomes reveal evolutionary signatures of predatory and nocturnal lifestyles. | Cho YS et al. | β | 2019 | β |
| Roads to the Fountain of Youth? Rejuvenating Intestinal Stem Cells. | Larrick JW et al. | β | 2019 | β |
| SIRT4 and Its Roles in Energy and Redox Metabolism in Health, Disease and During Exercise. | Han Y et al. | β | 2019 | β |
| Targeting Nuclear Receptors with PROTAC degraders. | Flanagan JJ et al. | β | 2019 | β |
| The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARΞ±. | Iershov A et al. | β | 2019 | β |
| The Journey of Thiazolidinediones as Modulators of PPARs for the Management of Diabetes: A Current Perspective. | Ahsan W | β | 2019 | β |
| The PPAR-microbiota-metabolic organ trilogy to fine-tune physiology. | Oh HYP et al. | β | 2019 | β |
| The Role of Mammalian Creb3-Like Transcription Factors in Response to Nutrients. | Khan HA et al. | β | 2019 | β |
| Toxic effects of boscalid in adult zebrafish (Danio rerio) on carbohydrate and lipid metabolism. | Qian L et al. | β | 2019 | β |
| Transcriptional Control of Brown and Beige Fat Development and Function. | Shapira SN et al. | β | 2019 | β |
| Transcriptional profiling of PPARΞ±-/- and CREB3L3-/- livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARΞ±. | Ruppert PMM et al. | β | 2019 | β |
| 2D DIGE proteomic analysis reveals fasting-induced protein remodeling through organ-specific transcription factor(s) in mice. | Kamata S et al. | β | 2018 | β |
| Adipogenic/lipogenic gene expression and fatty acid composition in chuck, loin, and round muscles in response to grain feeding of Yanbian Yellow cattle. | Li XZ et al. | β | 2018 | β |
| A Journey to Understand Glucose Homeostasis: Starting from Rat Glucose Transporter Type 2 Promoter Cloning to Hyperglycemia. | Ahn YH | β | 2018 | β |
| Basic mechanisms of the regulation of L-carnitine status in monogastrics and efficacy of L-carnitine as a feed additive in pigs and poultry. | Ringseis R et al. | β | 2018 | β |
| Bioinformatics Analysis and Competitive Regulation by Transcription Factors of <i>SIRT5</i> at the Core Promoter Region Using Bovine Adipocytes. | Hong J et al. | β | 2018 | β |
| Changes in peroxisome proliferator-activated receptor alpha target gene expression in peripheral blood mononuclear cells associated with non-alcoholic fatty liver disease. | Li TT et al. | β | 2018 | β |
| Correlation between PPAR-Ξ± methylation level in peripheral blood and atherosclerosis of NAFLD patients with DM. | Ju J et al. | β | 2018 | β |
| Cytochrome P450s and Alcoholic Liver Disease. | Lu Y et al. | β | 2018 | β |
| Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced Hepatic Steatosis in Mice. | Zhang K et al. | β | 2018 | β |
| Effects of Sanyaku and Its Constituent Diosgenin on the Fasted and Postprandial Hypertriacylglycerolemia in High-Fat-Diet-Fed KK- A <sup>y</sup> Mice. | Hashidume T et al. | β | 2018 | β |
| Effects of supplementing rumen-protected niacin on fiber composition and metabolism of skeletal muscle in dairy cows during early lactation. | Zeitz JO et al. | β | 2018 | β |
| Enhanced Hepatic PPARΞ± Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice. | Mayer AL et al. | β | 2018 | β |
| Enteric Microbiotaβ»Gutβ»Brain Axis from the Perspective of Nuclear Receptors. | Duszka K et al. | β | 2018 | β |
| Extrahepatic PPARΞ± modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice. | Brocker CN et al. | β | 2018 | β |
| Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid Ξ²-oxidation and ketogenesis via activating XBP1 signaling in liver. | Zhang M et al. | β | 2018 | β |
| Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis. | BonDurant LD et al. | β | 2018 | β |
| Fibroblast growth factor 21 regulates glucose metabolism in part by reducing renal glucose reabsorption. | Li S et al. | β | 2018 | β |
| Gene expression profiling during hibernation in the European hamster. | Gautier C et al. | β | 2018 | β |
| HDAC5 integrates ER stress and fasting signals to regulate hepatic fatty acid oxidation. | Qiu X et al. | β | 2018 | β |
| Hepatic peroxisome proliferator-activated receptor alpha mediates the major metabolic effects of Wy-14643. | Li G et al. | β | 2018 | β |
| Hepatic PPARΞ± function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1. | Zhao Z et al. | β | 2018 | β |
| Identification of IQ motif-containing GTPase-activating protein 1 as a regulator of long-term ketosis. | Erickson HL et al. | β | 2018 | β |
| Impact of skeletal muscle IL-6 on regulation of liver and adipose tissue metabolism during fasting. | Bertholdt L et al. | β | 2018 | β |
| Insights into the role of hepatocyte PPARΞ± activity in response to fasting. | RΓ©gnier M et al. | β | 2018 | β |
| Insights into the Role of PPARΞ²/Ξ΄ in NAFLD. | Chen J et al. | β | 2018 | β |
| Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis. | Liu Y et al. | β | 2018 | β |
| Ligand-Dependent Interaction of PPARΞ΄ With T-Cell Protein Tyrosine Phosphatase 45 Enhances Insulin Signaling. | Yoo T et al. | β | 2018 | β |
| Lipid profile of bovine blastocysts exposed to insulin during in vitro oocyte maturation. | Laskowski D et al. | β | 2018 | β |
| Lipolysis-Stimulating Peptide from Soybean Protects Against High Fat Diet-Induced Apoptosis in Skeletal Muscles. | Marthandam Asokan S et al. | β | 2018 | β |
| Magnolol Alleviates Inflammatory Responses and Lipid Accumulation by AMP-Activated Protein Kinase-Dependent Peroxisome Proliferator-Activated Receptor Ξ± Activation. | Tian Y et al. | β | 2018 | β |
| Mechanisms of Insulin Action and Insulin Resistance. | Petersen MC et al. | β | 2018 | β |
| Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha. | Li G et al. | β | 2018 | β |
| Metabolic gene expression and epigenetic effects of the ketone body Ξ²-hydroxybutyrate on H3K9ac in bovine cells, oocytes and embryos. | Sangalli JR et al. | β | 2018 | β |
| MicroRNA-124 Regulates Fatty Acid and Triglyceride Homeostasis. | Shaw TA et al. | β | 2018 | β |
| Molecular Actions of PPARΞ± in Lipid Metabolism and Inflammation. | Bougarne N et al. | β | 2018 | β |
| PCB126 Inhibits the Activation of AMPK-CREB Signal Transduction Required for Energy Sensing in Liver. | Gadupudi GS et al. | β | 2018 | β |
| Pentacyclic triterpenes: New tools to fight metabolic syndrome. | Sharma H et al. | β | 2018 | β |
| PIK3R3 regulates PPARΞ± expression to stimulate fatty acid Ξ²-oxidation and decrease hepatosteatosis. | Yang X et al. | β | 2018 | β |
| Pluripotency Transcription Factors and Metabolic Reprogramming of Mitochondria in Tumor-Initiating Stem-like Cells. | Machida K | β | 2018 | β |
| PPAR Agonists and Metabolic Syndrome: An Established Role? | Botta M et al. | β | 2018 | β |
| PPARs and Metabolic Disorders Associated with Challenged Adipose Tissue Plasticity. | Corrales P et al. | β | 2018 | β |
| Redox Regulation of Homeostasis and Proteostasis in Peroxisomes. | Walker CL et al. | β | 2018 | β |
| Repairing Mitochondrial Dysfunction in Disease. | Sorrentino V et al. | β | 2018 | β |
| Spatiotemporal compartmentalization of hepatic NADH and NADPH metabolism. | Goodman RP et al. | β | 2018 | β |
| Synthesis and evaluation of an orally available "Y"-shaped biaryl peroxisome proliferator-activated receptor Ξ΄ agonist. | Kim DS et al. | β | 2018 | β |
| The Diurnal Timing of Starvation Differently Impacts Murine Hepatic Gene Expression and Lipid Metabolism - A Systems Biology Analysis Using Self-Organizing Maps. | Rennert C et al. | β | 2018 | β |
| The Peroxisome Proliferator-Activated Receptor Ξ± is dispensable for cold-induced adipose tissue browning in mice. | Defour M et al. | β | 2018 | β |
| The PPARΞ±-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions. | Corton JC et al. | β | 2018 | β |
| The Role of PPAR and Its Cross-Talk with CAR and LXR in Obesity and Atherosclerosis. | Xu P et al. | β | 2018 | β |
| The whole transcriptome effects of the PPARΞ± agonist fenofibrate on livers of hepatocyte humanized mice. | de la Rosa Rodriguez MA et al. | β | 2018 | β |
| A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study. | Imamura F et al. | β | 2017 | β |
| Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARΞ±-FGF21 axis. | Chen X et al. | β | 2017 | β |
| A Specific ChREBP and PPARΞ± Cross-Talk Is Required for the Glucose-Mediated FGF21 Response. | Iroz A et al. | β | 2017 | β |
| Browning formation markers of subcutaneous adipose tissue in relation to resting energy expenditure, physical activity and diet in humans. | Dinas PC et al. | β | 2017 | β |
| Cellular models for the evaluation of the antiobesity effect of selected phytochemicals fromΒ food and herbs. | Tung YC et al. | β | 2017 | β |
| Connecting the Metabolic and Immune Responses to Cancer. | Flint TR et al. | β | 2017 | β |
| Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease. | Rotman Y et al. | β | 2017 | β |
| Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet. | Tognini P et al. | β | 2017 | β |
| Effect of an acute moderate-exercise session on metabolic and inflammatory profile of PPAR-Ξ± knockout mice. | Silveira LS et al. | β | 2017 | β |
| Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine <i>N</i>-methyltransferase. | van der Veen JN et al. | β | 2017 | β |
| Food restriction increase the expression of mTORC1 complex genes in the skeletal muscle of juvenile pacu (Piaractus mesopotamicus). | Paula TG et al. | β | 2017 | β |
| Ginseng and obesity: observations and understanding in cultured cells, animals and humans. | Zhang L et al. | β | 2017 | β |
| Glucocorticoid resistance as a major drive in sepsis pathology. | Dendoncker K et al. | β | 2017 | β |
| G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice. | Donepudi AC et al. | β | 2017 | β |
| Hearts lacking plasma membrane K<sub>ATP</sub> channels display changes in basal aerobic metabolic substrate preference and AMPK activity. | Youssef N et al. | β | 2017 | β |
| Hepatic lipid accumulation: cause and consequence of dysregulated glucoregulatory hormones. | Geisler CE et al. | β | 2017 | β |
| HMGCS2 enhances invasion and metastasis via direct interaction with PPARΞ± to activate Src signaling in colorectal cancer and oral cancer. | Chen SW et al. | β | 2017 | β |
| Insights into the Hexose Liver Metabolism-Glucose versus Fructose. | Geidl-Flueck B et al. | β | 2017 | β |
| In vitro and in vivo pharmacology of NXT629, a novel and selective PPARΞ± antagonist. | Stebbins KJ et al. | β | 2017 | β |
| In vitro bioassays to evaluate beneficial and adverse health effects of botanicals: promises and pitfalls. | Prinsloo G et al. | β | 2017 | β |
| Kefir alleviates obesity and hepatic steatosis in high-fat diet-fed mice by modulation of gut microbiota and mycobiota: targeted and untargeted community analysis with correlation of biomarkers. | Kim DH et al. | β | 2017 | β |
| Lipid oxidation products in the pathogenesis of non-alcoholic steatohepatitis. | Bellanti F et al. | β | 2017 | β |
| Liver and Metformin: Lessons of a fructose diet in mice. | Karise I et al. | β | 2017 | β |
| Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders. | Fenni S et al. | β | 2017 | β |
| Mechanistic insight into nuclear receptor-mediated regulation of bile acid metabolism and lipid homeostasis by grape seed procyanidin extract (GSPE). | Downing LE et al. | β | 2017 | β |
| MicroRNA-27a regulates hepatic lipid metabolism and alleviates NAFLD via repressing FAS and SCD1. | Zhang M et al. | β | 2017 | β |
| miR-212-5p suppresses lipid accumulation by targeting FAS and SCD1. | Guo Y et al. | β | 2017 | β |
| New Potential Biomarker Proteins for Alcoholic Liver Disease Identified by a Comparative Proteomics Approach. | Lee SJ et al. | β | 2017 | β |
| Nuclear Receptor PPARΞ± Agonist Wy-14,643 Ameliorates Hepatic Cell Death in Hepatic IKKΞ²-Deficient Mice. | Kim T et al. | β | 2017 | β |
| Nutrient-sensing nuclear receptors PPARΞ± and FXR control liver energy balance. | Preidis GA et al. | β | 2017 | β |
| Peroxisome Proliferator-Activated Receptors Associated with Nonalcoholic Fatty Liver Disease. | Wang N et al. | β | 2017 | β |
| Peroxisome proliferator-activated receptor Ξ± (PPARΞ±) contributes to control of melanogenesis in B16 F10 melanoma cells. | Grabacka M et al. | β | 2017 | β |
| PGC-1<i>Ξ±</i> and fasting-induced PDH regulation in mouse skeletal muscle. | Gudiksen A et al. | β | 2017 | β |
| PPARs in the central nervous system: roles in neurodegeneration and neuroinflammation. | Zolezzi JM et al. | β | 2017 | β |
| PPARΞ± augments heart function and cardiac fatty acid oxidation in early experimental polymicrobial sepsis. | Standage SW et al. | β | 2017 | β |
| PPARΞ±-dependent Insig2a overexpression inhibits SREBP-1c processing during fasting. | Lee JH et al. | β | 2017 | β |
| Prebiotic and Synbiotic Modifications of Beta Oxidation and Lipogenic Gene Expression after Experimental Hypercholesterolemia in Rat Liver. | Alves CC et al. | β | 2017 | β |
| Regulation of hepatic lipid deposition by phospholipid in large yellow croaker. | Cai Z et al. | β | 2017 | β |
| RORΞ± controls hepatic lipid homeostasis via negative regulation of PPARΞ³ transcriptional network. | Kim K et al. | β | 2017 | β |
| Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism. | CaparrΓ³s-MartΓn JA et al. | β | 2017 | β |
| Structural basis for specific ligation of the peroxisome proliferator-activated receptor Ξ΄. | Wu CC et al. | β | 2017 | β |
| Synthetic and natural Peroxisome Proliferator-Activated Receptor (PPAR) agonists as candidates for the therapy of the metabolic syndrome. | Tan CK et al. | β | 2017 | β |
| Targeting nuclear receptors for the treatment of fatty liver disease. | Tanaka N et al. | β | 2017 | β |
| The Ameliorative Effects of a Tocotrienol-Rich Fraction on the AGE-RAGE Axis and Hypertension in High-Fat-Diet-Fed Rats with Metabolic Syndrome. | Cheng HS et al. | β | 2017 | β |
| The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis. | Wettstein G et al. | β | 2017 | β |
| The role and regulation of the peroxisome proliferator activated receptor alpha in human liver. | Kersten S et al. | β | 2017 | β |
| Alternating Diet as a Preventive and Therapeutic Intervention for High Fat Diet-induced Metabolic Disorder. | Ma Y et al. | β | 2016 | β |
| Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame. | Ibrahim SH et al. | β | 2016 | β |
| Annual life-stage regulation of lipid metabolism and storage and association with PPARs in a migrant species: the gray catbird (Dumetella carolinensis). | Corder KR et al. | β | 2016 | β |
| A Novel Function of Hepatic FOG2 in Insulin Sensitivity and Lipid Metabolism Through PPARΞ±. | Guo Y et al. | β | 2016 | β |
| Astaxanthin reduces hepatic lipid accumulations in high-fat-fed C57BL/6J mice via activation of peroxisome proliferator-activated receptor (PPAR) alpha and inhibition of PPAR gamma and Akt. | Jia Y et al. | β | 2016 | β |
| Autonomic nervous system-mediated effects of galanin-like peptide on lipid metabolism in liver and adipose tissue. | Hirako S et al. | β | 2016 | β |
| Bidirectional Relationships and Disconnects between NAFLD and Features of the Metabolic Syndrome. | Wainwright P et al. | β | 2016 | β |
| Caloric restriction of db/db mice reverts hepatic steatosis and body weight with divergent hepatic metabolism. | Kim KE et al. | β | 2016 | β |
| Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARΞ±. | Ratman D et al. | β | 2016 | β |
| CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARΞ±. | Nakagawa Y et al. | β | 2016 | β |
| Dietary conjugated linoleic acid affects blood parameters, liver morphology and expression of selected hepatic genes in laying hens. | Koronowicz AA et al. | β | 2016 | β |
| Diminished Phosphorylation of CREB Is a Key Event in the Dysregulation of Gluconeogenesis and Glycogenolysis in PCB126 Hepatotoxicity. | Gadupudi GS et al. | β | 2016 | β |
| Environmental Chemicals Modulate Polar Bear (Ursus maritimus) Peroxisome Proliferator-Activated Receptor Gamma (PPARG) and Adipogenesis in Vitro. | Routti H et al. | β | 2016 | β |
| Fat Metabolism Regulates Satiety Behavior in C. elegans. | Hyun M et al. | β | 2016 | β |
| Fenofibrate Decreases Insulin Clearance and Insulin Secretion to Maintain Insulin Sensitivity. | Ramakrishnan SK et al. | β | 2016 | β |
| Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus. | So WY et al. | β | 2016 | β |
| Glucocorticoid receptor-PPARΞ± axis in fetal mouse liver prepares neonates for milk lipid catabolism. | Rando G et al. | β | 2016 | β |
| Hepatic adaptations to maintain metabolic homeostasis in response to fasting and refeeding in mice. | Geisler CE et al. | β | 2016 | β |
| Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator-Activated Receptor Ξ±. | Chen X et al. | β | 2016 | β |
| Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals. | Montagner A et al. | β | 2016 | β |
| Hepatic Fasting-Induced PPARΞ± Activity Does Not Depend on Essential Fatty Acids. | Polizzi A et al. | β | 2016 | β |
| Hepatitis B Virus X Protein Induces Hepatic Steatosis by Enhancing the Expression of Liver Fatty Acid Binding Protein. | Wu YL et al. | β | 2016 | β |
| Liver PPARΞ± is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. | Montagner A et al. | β | 2016 | β |
| Low dose monoethyl phthalate (MEP) exposure triggers proliferation by activating PDX-1 at 1.1B4 human pancreatic beta cells. | GΓΌven C et al. | β | 2016 | β |
| Malfunction in Mitochondrial Ξ²-Oxidation Contributes to Lipid Accumulation in Hepatocyte-Like Cells Derived from Citrin Deficiency-Induced Pluripotent Stem Cells. | Kim Y et al. | β | 2016 | β |
| Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction. | van Zutphen T et al. | β | 2016 | β |
| Mammalian aquaglyceroporin function in metabolism. | Laforenza U et al. | β | 2016 | β |
| Mechanisms and metabolic regulation of PPARΞ± activation in Nile tilapia (Oreochromis niloticus). | Ning LJ et al. | β | 2016 | β |
| Mechanisms of Ξ²-cell functional adaptation to changes in workload. | Wortham M et al. | β | 2016 | β |
| MiR-122 targets the vanin 1 gene to regulate its expression in chickens. | Li Y et al. | β | 2016 | β |
| Molecular basis of alcoholic fatty liver disease: From incidence to treatment. | LΓvero FA et al. | β | 2016 | β |
| Molecular characterization of carnitine palmitoyltransferase IA in Megalobrama amblycephala and effects on its expression of feeding status and dietary lipid and berberine. | Lu KL et al. | β | 2016 | β |
| Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules. | Moseti D et al. | β | 2016 | β |
| Nuclear receptors and AMPK: can exercise mimetics cure diabetes? | Wall CE et al. | β | 2016 | β |
| Nutritional and Hormonal Regulation of Citrate and Carnitine/Acylcarnitine Transporters: Two Mitochondrial Carriers Involved in Fatty Acid Metabolism. | Giudetti AM et al. | β | 2016 | β |
| p21<sup>Cip1</sup> plays a critical role in the physiological adaptation to fasting through activation of PPARΞ±. | Lopez-Guadamillas E et al. | β | 2016 | β |
| PPARs and Mitochondrial Metabolism: From NAFLD to HCC. | Mello T et al. | β | 2016 | β |
| PPARΞ± activation drives demethylation of the CpG islands of the Gadd45b promoter in the mouse liver. | Kim JH et al. | β | 2016 | β |
| PPARΞ± (Peroxisome Proliferator-activated Receptor Ξ±) Activation Reduces Hepatic CEACAM1 Protein Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition. | Ramakrishnan SK et al. | β | 2016 | β |
| Promising therapies for treatment of nonalcoholic steatohepatitis. | Noureddin M et al. | β | 2016 | β |
| Regulated Inflammation and Lipid Metabolism in Colon mRNA Expressions of Obese Germfree Mice Responding to <i>Enterobacter cloacae</i> B29 Combined with the High Fat Diet. | Yan H et al. | β | 2016 | β |
| Regulation of Ketone Body Metabolism and the Role of PPARΞ±. | Grabacka M et al. | β | 2016 | β |
| Restriction of dietary protein does not promote hepatic lipogenesis in lean or fatty pigs. | Madeira MS et al. | β | 2016 | β |
| Resveratrol enhances HBV replication through activating Sirt1-PGC-1Ξ±-PPARΞ± pathway. | Shi Y et al. | β | 2016 | β |
| Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism. | Zhang P et al. | β | 2016 | β |
| Role of peroxisome proliferator-activated receptor alpha in the expression of hepatic fatty acid oxidation-related genes in chickens. | Honda K et al. | β | 2016 | β |
| Roles of Peroxisome Proliferator-Activated Receptor Ξ± in Bitter Melon Seed Oil-Corrected Lipid Disorders and Conversion of Ξ±-Eleostearic Acid into Rumenic Acid in C57BL/6J Mice. | Chang YY et al. | β | 2016 | β |
| SIK2 regulates fasting-induced PPARΞ± activity and ketogenesis through p300. | Zhang ZN et al. | β | 2016 | β |
| Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans. | Cedernaes J et al. | β | 2016 | β |
| Sports genetics: the PPARA gene and athletes' high ability in endurance sports. A systematic review and meta-analysis. | Lopez-Leon S et al. | β | 2016 | β |
| The Biochemistry and Physiology of Mitochondrial Fatty Acid Ξ²-Oxidation and Its Genetic Disorders. | Houten SM et al. | β | 2016 | β |
| Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. | Degirolamo C et al. | β | 2016 | β |
| Transcriptional coordination of hepatic autophagy by nutrient-sensing nuclear receptor PPARΞ± and FXR. | Lee JM | β | 2016 | β |
| Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity. | Flint TR et al. | β | 2016 | β |
| White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways. | Barquissau V et al. | β | 2016 | β |
| Zinc finger protein 407 overexpression upregulates PPAR target gene expression and improves glucose homeostasis in mice. | Charrier A et al. | β | 2016 | β |
| Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice. | Hong F et al. | β | 2015 | β |
| Argan oil prevents down-regulation induced by endotoxin on liver fatty acid oxidation and gluconeogenesis and on peroxisome proliferator-activated receptor gamma coactivator-1Ξ±, (PGC-1Ξ±), peroxisome proliferator-activated receptor Ξ± (PPARΞ±) and estrogen related receptor Ξ± (ERRΞ±). | El Kebbaj R et al. | β | 2015 | β |
| ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1Ξ±/PPAR-Ξ± signaling. | Khan SA et al. | β | 2015 | β |
| Bioenergetic cues shift FXR splicing towards FXRΞ±2 to modulate hepatic lipolysis and fatty acid metabolism. | Correia JC et al. | β | 2015 | β |
| Body condition score at calving affects systemic and hepatic transcriptome indicators of inflammation and nutrient metabolism in grazing dairy cows. | Akbar H et al. | β | 2015 | β |
| Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis. | Li LO et al. | β | 2015 | β |
| Decreased liver triglyceride content in adult rats exposed to protein restriction during gestation and lactation: role of hepatic triglyceride utilization. | Qasem RJ et al. | β | 2015 | β |
| Drug-induced fatty liver disease: An overview of pathogenesis and management. | Satapathy SK et al. | β | 2015 | β |
| Fatty acid signaling: the new function of intracellular lipases. | Papackova Z et al. | β | 2015 | β |
| Fibrates and cholestasis. | Ghonem NS et al. | β | 2015 | β |
| Fish oil decreases hepatic lipogenic genes in rats fasted and refed on a high fructose diet. | de Castro GS et al. | β | 2015 | β |
| Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop. | Patel R et al. | β | 2015 | β |
| Hepatic AQP9 expression in male rats is reduced in response to PPARΞ± agonist treatment. | Lebeck J et al. | β | 2015 | β |
| Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor Ξ± (PPARΞ±) in a mouse liver gene expression compendium. | Oshida K et al. | β | 2015 | β |
| Impact of nutrients on circadian rhythmicity. | Oosterman JE et al. | β | 2015 | β |
| Inhibition of Dexamethasone-induced Fatty Liver Development by Reducing miR-17-5p Levels. | Du WW et al. | β | 2015 | β |
| Insights into Transcriptional Regulation of Hepatic Glucose Production. | Anyamaneeratch K et al. | β | 2015 | β |
| Insulin resistance in clinical and experimental alcoholic liver disease. | Carr RM et al. | β | 2015 | β |
| In vitro evaluation of dual agonists for PPARΞ³/Ξ² from the flower of Edgeworthia gardneri (wall.) Meisn. | Gao D et al. | β | 2015 | β |
| Kaempferol ameliorates symptoms of metabolic syndrome by regulating activities of liver X receptor-Ξ². | Hoang MH et al. | β | 2015 | β |
| Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism. | Helenius TO et al. | β | 2015 | β |
| Ketone Body Therapy Protects From Lipotoxicity and Acute Liver Failure Upon PparΞ± Deficiency. | Pawlak M et al. | β | 2015 | β |
| Lack of sterol regulatory element binding factor-1c imposes glial Fatty Acid utilization leading to peripheral neuropathy. | Cermenati G et al. | β | 2015 | β |
| Ligand-activated PPARΞ±-dependent DNA demethylation regulates the fatty acid Ξ²-oxidation genes in the postnatal liver. | Ehara T et al. | β | 2015 | β |
| Liver glycogen reduces food intake and attenuates obesity in a high-fat diet-fed mouse model. | LΓ³pez-Soldado I et al. | β | 2015 | β |
| 'Micro-managers' of hepatic lipid metabolism and NAFLD. | Liu W et al. | β | 2015 | β |
| Mitochondrial sirtuins and their relationships with metabolic disease and cancer. | Kumar S et al. | β | 2015 | β |
| Molecular mechanism of PPARΞ± action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease. | Pawlak M et al. | β | 2015 | β |
| Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue. | Fu J et al. | β | 2015 | β |
| n-3 polyunsaturated fatty acids and insulin secretion. | Wang X et al. | β | 2015 | β |
| Novel genomic signals of recent selection in an Ethiopian population. | Tekola-Ayele F et al. | β | 2015 | β |
| Nutrigenomics: A controversy. | Pavlidis C et al. | β | 2015 | β |
| Over-expression of Follistatin-like 3 attenuates fat accumulation and improves insulin sensitivity in mice. | Brandt C et al. | β | 2015 | β |
| Peroxisome-mitochondria interplay and disease. | Schrader M et al. | β | 2015 | β |
| Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions. | Lee WS et al. | β | 2015 | β |
| Peroxisome proliferator-activated receptor transactivational effects in HepG2 cells of cembranoids from the soft coral Lobophytum crassum Von Marenzeller. | Thao NP et al. | β | 2015 | β |
| Peroxisomes in cardiomyocytes and the peroxisome / peroxisome proliferator-activated receptor-loop. | Colasante C et al. | β | 2015 | β |
| Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice. | Jo YS et al. | β | 2015 | β |
| PPARs and ERRs: molecular mediators of mitochondrial metabolism. | Fan W et al. | β | 2015 | β |
| PPARΞ±-Deficient ob/ob Obese Mice Become More Obese and Manifest Severe Hepatic Steatosis Due to Decreased Fatty Acid Oxidation. | Gao Q et al. | β | 2015 | β |
| PPARΞ± Is Required for PPARΞ΄ Action in Regulation of Body Weight and Hepatic Steatosis in Mice. | Garbacz WG et al. | β | 2015 | β |
| PPARΞ± regulates endothelial progenitor cell maturation and myeloid lineage differentiation through a NADPH oxidase-dependent mechanism in mice. | Vergori L et al. | β | 2015 | β |
| PPARΞ± via HNF4Ξ± regulates the expression of genes encoding hepatic amino acid catabolizing enzymes to maintain metabolic homeostasis. | Contreras AV et al. | β | 2015 | β |
| Renoprotective Effects of Fenofibrate via Modulation of LKB1/AMPK mRNA Expression and Endothelial Dysfunction in a Rat Model of Diabetic Nephropathy. | Al-Rasheed NM et al. | β | 2015 | β |
| Response of the cholesterol metabolism to a negative energy balance in dairy cows depends on the lactational stage. | Gross JJ et al. | β | 2015 | β |
| Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPARΞ±. | Komatsu M et al. | β | 2015 | β |
| The dipeptide H-Trp-Arg-OH (WR) Is a PPARΞ± agonist and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells. | Jia Y et al. | β | 2015 | β |
| The effects of perfluorinated chemicals on adipocyte differentiation in vitro. | Watkins AM et al. | β | 2015 | β |
| The impact of PPARΞ± activation on whole genome gene expression in human precision cut liver slices. | Janssen AW et al. | β | 2015 | β |
| Ursolic acid improves lipid and glucose metabolism in high-fat-fed C57BL/6J mice by activating peroxisome proliferator-activated receptor alpha and hepatic autophagy. | Jia Y et al. | β | 2015 | β |
| 2-Pentanone production from hexanoic acid by Penicillium roqueforti from blue cheese: is this the pathway used in humans? | Walker V et al. | β | 2014 | β |
| Adiposity and fat metabolism in lactating and fasting northern elephant seals. | Crocker DE et al. | β | 2014 | β |
| A Moderate Zinc Deficiency Does Not Impair Gene Expression of PPARΞ±, PPARΞ³, and Mitochondrial Enoyl-CoA Delta Isomerase in the Liver of Growing Rats. | Justus J et al. | β | 2014 | β |
| A role for the human peroxisomal half-transporter ABCD3 in the oxidation of dicarboxylic acids. | van Roermund CW et al. | β | 2014 | β |
| Berberine protects liver from ethanol-induced oxidative stress and steatosis in mice. | Zhang P et al. | β | 2014 | β |
| Changes in energy-regulated molecules in the trophocytes and fat cells of young and old worker honeybees (Apis mellifera). | Hsu CY et al. | β | 2014 | β |
| Cholesterol-cholate-butterfat diet offers multi-organ dysfunction in rats. | Jamshed H et al. | β | 2014 | β |
| Circadian clocks and energy metabolism. | Sancar G et al. | β | 2014 | β |
| Comparison of hepatic adaptation in extreme metabolic phenotypes observed in early lactation dairy cows on-farm. | van Dorland HA et al. | β | 2014 | β |
| Distinct metabolic pathways trigger adipocyte fat accumulation induced by high-carbohydrate and high-fat diets. | Ferreira AV et al. | β | 2014 | β |
| Dysregulation of hepatic zinc transporters in a mouse model of alcoholic liver disease. | Sun Q et al. | β | 2014 | β |
| Effect of fibrate treatment on liver function tests in patients with the metabolic syndrome. | Gandhi N et al. | β | 2014 | β |
| Effects of Fortunella margarita fruit extract on metabolic disorders in high-fat diet-induced obese C57BL/6 mice. | Tan S et al. | β | 2014 | β |
| Energy metabolism in the liver. | Rui L | β | 2014 | β |
| Energy-regulated molecules maintain young status in the trophocytes and fat cells of old queen honeybees. | Hsu CY et al. | β | 2014 | β |
| Ethanol and liver: recent insights into the mechanisms of ethanol-induced fatty liver. | Liu J | β | 2014 | β |
| Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice. | GarcΓa-Arevalo M et al. | β | 2014 | β |
| Fatty acid binding protein 4 and 5 play a crucial role in thermogenesis under the conditions of fasting and cold stress. | Syamsunarno MR et al. | β | 2014 | β |
| FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting. | Liang Q et al. | β | 2014 | β |
| Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting. | Gu Q et al. | β | 2014 | β |
| Hepatic IRE1Ξ± regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARΞ± axis signalling. | Shao M et al. | β | 2014 | β |
| Hepatic oxidative stress activates the Gadd45b gene by way of degradation of the transcriptional repressor STAT3. | Kim JH et al. | β | 2014 | β |
| Hepatic sirtuin 1 is dispensable for fibrate-induced peroxisome proliferator-activated receptor-Ξ± function in vivo. | Bonzo JA et al. | β | 2014 | β |
| Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion. | Mattijssen F et al. | β | 2014 | β |
| Immunologic, metabolic and genetic factors in hepatitis C virus infection. | Fierro NA et al. | β | 2014 | β |
| Impact of fasting time on hepatic lipid metabolism in nutritional animal studies. | Ikeda I et al. | β | 2014 | β |
| Impairments of hepatic gluconeogenesis and ketogenesis in PPARΞ±-deficient neonatal mice. | Cotter DG et al. | β | 2014 | β |
| Integrated physiology and systems biology of PPARΞ±. | Kersten S | β | 2014 | β |
| Integrative analyses of hepatic differentially expressed genes and blood biomarkers during the peripartal period between dairy cows overfed or restricted-fed energy prepartum. | Shahzad K et al. | β | 2014 | β |
| Lipid-lowering effects of Danhong injection on hyperlipidemia rats. | Chen J et al. | β | 2014 | β |
| LT175 is a novel PPARΞ±/Ξ³ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. | Gilardi F et al. | β | 2014 | β |
| Metabolic impact of the glycerol channels AQP7 and AQP9 in adipose tissue and liver. | Lebeck J | β | 2014 | β |
| Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43. | Stribl C et al. | β | 2014 | β |
| Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARΞ±) as a case study. | Corton JC et al. | β | 2014 | β |
| Modulation of fatty acid and bile acid metabolism by peroxisome proliferator-activated receptor Ξ± protects against alcoholic liver disease. | Li HH et al. | β | 2014 | β |
| Molecular pathways in non-alcoholic fatty liver disease. | Berlanga A et al. | β | 2014 | β |
| MRNA expression of genes regulating lipid metabolism in ringed seals (Pusa hispida) from differently polluted areas. | Castelli MG et al. | β | 2014 | β |
| Neuroendocrine and metabolic components of dopamine agonist amelioration of metabolic syndrome in SHR rats. | Ezrokhi M et al. | β | 2014 | β |
| Nuclear receptors and metabolism: from feast to famine. | Hong SH et al. | β | 2014 | β |
| Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARΞ±. | Lu Y et al. | β | 2014 | β |
| Peroxisome proliferator-activated receptor-Ξ± activation and excess energy burning in hepatocarcinogenesis. | Misra P et al. | β | 2014 | β |
| Pharmacological doses of niacin stimulate the expression of genes involved in carnitine uptake and biosynthesis and improve the carnitine status of obese Zucker rats. | Couturier A et al. | β | 2014 | β |
| PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism. | van Diepen JA et al. | β | 2014 | β |
| PPARs Integrate the Mammalian Clock and Energy Metabolism. | Chen L et al. | β | 2014 | β |
| Regulation of energy metabolism by long-chain fatty acids. | Nakamura MT et al. | β | 2014 | β |
| Regulation of glucose homeostasis and lipid metabolism by PPP1R3G-mediated hepatic glycogenesis. | Zhang Y et al. | β | 2014 | β |
| Renal response to short- and long-term exercise in very-long-chain acyl-CoA dehydrogenase-deficient (VLCAD(-/-)) mice. | Tucci S et al. | β | 2014 | β |
| SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation. | Pang S et al. | β | 2014 | β |
| SteatoNet: the first integrated human metabolic model with multi-layered regulation to investigate liver-associated pathologies. | Naik A et al. | β | 2014 | β |
| The dipeptide H-Trp-Glu-OH (WE) shows agonistic activity to peroxisome proliferator-activated protein-Ξ± and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells. | Jia Y et al. | β | 2014 | β |
| The roles of peroxisome proliferator-activated receptors in the metabolic syndrome. | Mansour M | β | 2014 | β |
| Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization. | Kawano Y et al. | β | 2014 | β |
| Tissue-specific expression of monocarboxylate transporters during fasting in mice. | Schutkowski A et al. | β | 2014 | β |
| Transcriptional regulation of fibroblast growth factor 21 expression. | Bae KH et al. | β | 2014 | β |
| Transcriptomic signatures of peroxisome proliferator-activated receptor Ξ± (PPARΞ±) in different mouse liver models identify novel aspects of its biology. | Szalowska E et al. | β | 2014 | β |
| Uridine prevents fenofibrate-induced fatty liver. | Le TT et al. | β | 2014 | β |
| Vitamin D and energy homeostasis: of mice and men. | Bouillon R et al. | β | 2014 | β |
| Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice. | Dankel SN et al. | β | 2014 | β |
| Ξ²-Aminoisobutyric acid induces browning of white fat and hepatic Ξ²-oxidation and is inversely correlated with cardiometabolic risk factors. | Roberts LD et al. | β | 2014 | β |
| Ξ©-3 fatty acids prevent hepatic steatosis, independent of PPAR-Ξ± activity, in a murine model of parenteral nutrition-associated liver disease. | Prince E et al. | β | 2014 | β |
| 10E,12Z-conjugated linoleic acid impairs adipocyte triglyceride storage by enhancing fatty acid oxidation, lipolysis, and mitochondrial reactive oxygen species. | den Hartigh LJ et al. | β | 2013 | β |
| A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting. | Syamsunarno MR et al. | β | 2013 | β |
| Activation of human stearoyl-coenzyme A desaturase 1 contributes to the lipogenic effect of PXR in HepG2 cells. | Zhang J et al. | β | 2013 | β |
| Activation of PPARΞ± ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress. | Chan SM et al. | β | 2013 | β |
| An active metabolite of oltipraz (M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK. | Kim TH et al. | β | 2013 | β |
| Animal models of chronic liver diseases. | Liu Y et al. | β | 2013 | β |
| A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARΞ±. | Ducheix S et al. | β | 2013 | β |
| Cellular mechanisms regulating fuel metabolism in mammals: role of adipose tissue and lipids during prolonged food deprivation. | Viscarra JA et al. | β | 2013 | β |
| Concurrent activation of liver X receptor and peroxisome proliferator-activated receptor alpha exacerbates hepatic steatosis in high fat diet-induced obese mice. | Gao M et al. | β | 2013 | β |
| Differentially expressed genes in adipocytokine signaling pathway of adipose tissue in pregnancy. | Ogunyemi D et al. | β | 2013 | β |
| Differential regulation of the expressions of the PGC-1Ξ± splice variants, lipins, and PPARΞ± in heart compared to liver. | Kok BPC et al. | β | 2013 | β |
| Dissociating fatty liver and diabetes. | Sun Z et al. | β | 2013 | β |
| Dynamics of PPARs, fatty acid metabolism genes and lipid classes in eggs and early larvae of a teleost. | Cunha I et al. | β | 2013 | β |
| Effects of short term fasting on the expression of genes involved in lipid metabolism in chicks. | Saneyasu T et al. | β | 2013 | β |
| Effects of short-term refeeding on the expression of genes involved in lipid metabolism in chicks (Gallus gallus). | Saneyasu T et al. | β | 2013 | β |
| Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects. | Egli L et al. | β | 2013 | β |
| Fasting of mice: a review. | Jensen TL et al. | β | 2013 | β |
| Feedback looping between ChREBP and PPARΞ± in the regulation of lipid metabolism in brown adipose tissues. | Iizuka K et al. | β | 2013 | β |
| Fenofibrate, a peroxisome proliferator-activated receptor Ξ±-agonist, blocks lipopolysaccharide-induced inflammatory pathways in mouse liver. | Won TW | β | 2013 | β |
| Fenofibrate, a peroxisome proliferator-activated receptor Ξ± ligand, prevents abnormal liver function induced by a fasting-refeeding process. | Lee JN et al. | β | 2013 | β |
| Flavonoids as dietary regulators of nuclear receptor activity. | Avior Y et al. | β | 2013 | β |
| Free radical biology for medicine: learning from nonalcoholic fatty liver disease. | Serviddio G et al. | β | 2013 | β |
| Functional Role of PPARs in Ruminants: Potential Targets for Fine-Tuning Metabolism during Growth and Lactation. | Bionaz M et al. | β | 2013 | β |
| Genes involved in carnitine synthesis and carnitine uptake are up-regulated in the liver of sows during lactation. | Rosenbaum S et al. | β | 2013 | β |
| Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: a double-blind placebo-controlled study. | Sakata R et al. | β | 2013 | β |
| In vivo actions of peroxisome proliferator-activated receptors: glycemic control, insulin sensitivity, and insulin secretion. | Eldor R et al. | β | 2013 | β |
| Keap1-knockdown decreases fasting-induced fatty liver via altered lipid metabolism and decreased fatty acid mobilization from adipose tissue. | Xu J et al. | β | 2013 | β |
| Lipid-lowering fibrates extend C. elegans lifespan in a NHR-49/PPARalpha-dependent manner. | BrandstΓ€dt S et al. | β | 2013 | β |
| Lipoic acid prevents liver metabolic changes induced by administration of a fructose-rich diet. | Castro MC et al. | β | 2013 | β |
| Liver lipid content and inflammometabolic indices in peripartal dairy cows are altered in response to prepartal energy intake and postpartal intramammary inflammatory challenge. | Graugnard DE et al. | β | 2013 | β |
| Maternal dietary restriction alters offspring's sleep homeostasis. | Shimizu N et al. | β | 2013 | β |
| Melatonin and peripheral circuitries: insights on appetite and metabolism in Danio rerio. | Piccinetti CC et al. | β | 2013 | β |
| Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues. | Schupp M et al. | β | 2013 | β |
| Methionine restriction affects the phenotypic and transcriptional response of rainbow trout (Oncorhynchus mykiss) to carbohydrate-enriched diets. | Craig PM et al. | β | 2013 | β |
| Molecular Interactions between NAFLD and Xenobiotic Metabolism. | Naik A et al. | β | 2013 | β |
| Mouse KLF11 regulates hepatic lipid metabolism. | Zhang H et al. | β | 2013 | β |
| Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors. | Goto T et al. | β | 2013 | β |
| Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARΞ±-dependent and -independent pathways. | Zhang H et al. | β | 2013 | β |
| Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARΞ±. | Jensen-Urstad AP et al. | β | 2013 | β |
| Nutritional lipidomics: molecular metabolism, analytics, and diagnostics. | Smilowitz JT et al. | β | 2013 | β |
| Oxidized metabolites of linoleic acid as biomarkers of liver injury in nonalcoholic steatohepatitis. | Santoro N et al. | β | 2013 | β |
| Peroxisome proliferator-activated receptor genetic polymorphisms and nonalcoholic Fatty liver disease: any role in disease susceptibility? | Dongiovanni P et al. | β | 2013 | β |
| Pex11Ξ± deficiency impairs peroxisome elongation and division and contributes to nonalcoholic fatty liver in mice. | Weng H et al. | β | 2013 | β |
| Pharmacological approaches to restore mitochondrial function. | Andreux PA et al. | β | 2013 | β |
| Plant-based foods as a source of lipotropes for human nutrition: a survey of in vivo studies. | Fardet A et al. | β | 2013 | β |
| Possible role of intestinal fatty acid oxidation in the eating-inhibitory effect of the PPAR-Ξ± agonist Wy-14643 in high-fat diet fed rats. | Karimian Azari E et al. | β | 2013 | β |
| PPAR-Ξ± as a key nutritional and environmental sensor for metabolic adaptation. | Contreras AV et al. | β | 2013 | β |
| RAP1 protects from obesity through its extratelomeric role regulating gene expression. | MartΓnez P et al. | β | 2013 | β |
| Road to exercise mimetics: targeting nuclear receptors in skeletal muscle. | Fan W et al. | β | 2013 | β |
| SIRT4 represses peroxisome proliferator-activated receptor Ξ± activity to suppress hepatic fat oxidation. | Laurent G et al. | β | 2013 | β |
| Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor Ξ± in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity. | Ross JS et al. | β | 2013 | β |
| The liver X receptor: a master regulator of the gut-liver axis and a target for non alcoholic fatty liver disease. | Ducheix S et al. | β | 2013 | β |
| The nexus of chromatin regulation and intermediary metabolism. | Gut P et al. | β | 2013 | β |
| The orphan nuclear receptors at their 25-year reunion. | Mullican SE et al. | β | 2013 | β |
| Transcriptional Regulation of the Mitochondrial Citrate and Carnitine/Acylcarnitine Transporters: Two Genes Involved in Fatty Acid Biosynthesis and Ξ²-oxidation. | Iacobazzi V et al. | β | 2013 | β |
| Transcriptional repression of mitochondrial function in aging: a novel role for the silencing mediator of retinoid and thyroid hormone receptors co-repressor. | Liu S et al. | β | 2013 | β |
| Treatment with pharmacological PPARΞ± agonists stimulates the ubiquitin proteasome pathway and myofibrillar protein breakdown in skeletal muscle of rodents. | Ringseis R et al. | β | 2013 | β |
| VASP increases hepatic fatty acid oxidation by activating AMPK in mice. | Tateya S et al. | β | 2013 | β |
| Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. | Gut P et al. | β | 2013 | β |
| Ο-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. | O'Rourke EJ et al. | β | 2013 | β |
| Actions and interactions of AMPK with insulin, the peroxisomal-proliferator activated receptors and sirtuins. | Holness MJ et al. | β | 2012 | β |
| Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21. | Cyphert HA et al. | β | 2012 | β |
| A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting. | Hugo SE et al. | β | 2012 | β |
| Animal models of cutaneous and hepatic fibrosis. | Smith GP | β | 2012 | β |
| Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. | Takahashi Y et al. | β | 2012 | β |
| Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer. | Ament Z et al. | β | 2012 | β |
| A six-month supplementation of mulberry, korean red ginseng, and banaba decreases biomarkers of systemic low-grade inflammation in subjects with impaired glucose tolerance and type 2 diabetes. | Kim HJ et al. | β | 2012 | β |
| Atopic dermatitis causes lipid accumulation in the liver of NC/Nga mouse. | Seino S et al. | β | 2012 | β |
| Biological role, clinical significance, and therapeutic possibilities of the recently discovered metabolic hormone fibroblastic growth factor 21. | Iglesias P et al. | β | 2012 | β |
| Bixin activates PPARΞ± and improves obesity-induced abnormalities of carbohydrate and lipid metabolism in mice. | Goto T et al. | β | 2012 | β |
| Characterization of Paralichthys olivaceus peroxisome proliferator-activated receptor-Ξ± gene as a master regulator of flounder lipid metabolism. | Cho HK et al. | β | 2012 | β |
| Conditional Expression of Human PPARΞ΄ and a Dominant Negative Variant of hPPARΞ΄ In Vivo. | Higgins LG et al. | β | 2012 | β |
| Control of metabolism by nutrient-regulated nuclear receptors acting in the brain. | Bantubungi K et al. | β | 2012 | β |
| Development of improved PPARΞ²/Ξ΄ inhibitors. | Toth PM et al. | β | 2012 | β |
| DNA methylation at differentially methylated regions of imprinted genes is resistant to developmental programming by maternal nutrition. | Ivanova E et al. | β | 2012 | β |
| Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. | Potthoff MJ et al. | β | 2012 | β |
| Expression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation. | Schlegel G et al. | β | 2012 | β |
| FGF21 as a therapeutic reagent. | Zhao Y et al. | β | 2012 | β |
| Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor Ξ± in mouse liver reveals extensive sharing of binding sites. | Boergesen M et al. | β | 2012 | β |
| Genome-wide transcript profiling indicates induction of energy-generating pathways and an adaptive immune response in the liver of sows during lactation. | Rosenbaum S et al. | β | 2012 | β |
| Gluconeogenesis is associated with high rates of tricarboxylic acid and pyruvate cycling in fasting northern elephant seals. | Champagne CD et al. | β | 2012 | β |
| Health implications of high dietary omega-6 polyunsaturated Fatty acids. | Patterson E et al. | β | 2012 | β |
| Hepatic mitochondrial dysfunction induced by fatty acids and ethanol. | Gyamfi D et al. | β | 2012 | β |
| Hepatitis C virus to hepatocellular carcinoma. | Jahan S et al. | β | 2012 | β |
| Insulin concentration modulates hepatic lipid accumulation in mice in part via transcriptional regulation of fatty acid transport proteins. | Softic S et al. | β | 2012 | β |
| Klotho and Ξ²Klotho. | Kuro-o M | β | 2012 | β |
| Lack of reelin modifies the gene expression in the small intestine of mice. | GarcΓa-Miranda P et al. | β | 2012 | β |
| Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity. | Kidani Y et al. | β | 2012 | β |
| Major facilitator superfamily domain-containing protein 2a (MFSD2A) has roles in body growth, motor function, and lipid metabolism. | Berger JH et al. | β | 2012 | β |
| mTOR, metabolism, and the regulation of T-cell differentiation and function. | Waickman AT et al. | β | 2012 | β |
| Neuron-specific deletion of peroxisome proliferator-activated receptor delta (PPARΞ΄) in mice leads to increased susceptibility to diet-induced obesity. | Kocalis HE et al. | β | 2012 | β |
| NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1Ξ² genes. | Hirotsu Y et al. | β | 2012 | β |
| Nuclear receptors in nonalcoholic Fatty liver disease. | LΓ³pez-VelΓ‘zquez JA et al. | β | 2012 | β |
| Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids. | Houten SM et al. | β | 2012 | β |
| Peroxisomal localization and circadian regulation of ubiquitin-specific protease 2. | Molusky MM et al. | β | 2012 | β |
| Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity. | Patterson AD et al. | β | 2012 | β |
| Peroxisome proliferator-activated receptorΞ± agonists differentially regulate inhibitor of DNA binding expression in rodents and human cells. | GonzΓ‘lez Mdel C et al. | β | 2012 | β |
| Plasma mannose-binding lectin is stimulated by PPARΞ± in humans. | Rakhshandehroo M et al. | β | 2012 | β |
| Potent PPARΞ± activator derived from tomato juice, 13-oxo-9,11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice. | Kim YI et al. | β | 2012 | β |
| PPARs: fatty acid sensors controlling metabolism. | Poulsen Ll et al. | β | 2012 | β |
| PPARΞ± as a Transcriptional Regulator for Detoxification of Plant Diet-Derived Unfavorable Compounds. | Ashibe B et al. | β | 2012 | β |
| PPARΞ± is down-regulated following liver transplantation in mice. | Nakagawa K et al. | β | 2012 | β |
| Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. | Rolo AP et al. | β | 2012 | β |
| S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator-activated receptor alpha activity in the liver. | Kim K et al. | β | 2012 | β |
| The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury. | Elias-MirΓ³ M et al. | β | 2012 | β |
| The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica inhibits high-fat diet-induced hepatic steatosis via hepatic PPARΞ± activation. | Shin SS et al. | β | 2012 | β |
| The mouse gene encoding the carnitine biosynthetic enzyme 4-N-trimethylaminobutyraldehyde dehydrogenase is regulated by peroxisome proliferator-activated receptor Ξ±. | Wen G et al. | β | 2012 | β |
| The Role of PPARΞ³ in the Transcriptional Control by Agonists and Antagonists. | Tsukahara T | β | 2012 | β |
| Transdifferentiation of MALME-3M and MCF-7 Cells toward Adipocyte-like Cells is Dependent on Clathrin-mediated Endocytosis. | Carcel-Trullols J et al. | β | 2012 | β |
| Ξ²-Catenin regulates hepatic mitochondrial function and energy balance in mice. | Lehwald N et al. | β | 2012 | β |
| 13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophages. | KΓ€mmerer I et al. | β | 2011 | β |
| Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes. | Goto T et al. | β | 2011 | β |
| Adipose tissue-targeted 11Ξ²-hydroxysteroid dehydrogenase type 1 inhibitor protects against diet-induced obesity. | Liu J et al. | β | 2011 | β |
| AMPK regulates circadian rhythms in a tissue- and isoform-specific manner. | Um JH et al. | β | 2011 | β |
| A role for PPARΞ± in the regulation of arginine metabolism and nitric oxide synthesis. | Guelzim N et al. | β | 2011 | β |
| Caloric restriction and antiaging effects. | Xiang L et al. | β | 2011 | β |
| Caloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPAR{alpha}/PGC1{alpha} and thermogenic glycerolipid/fatty acid cycling. | Rame JE et al. | β | 2011 | β |
| ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells. | Boergesen M et al. | β | 2011 | β |
| Consequences of PPAR(Ξ±) Invalidation on Glutathione Synthesis: Interactions with Dietary Fatty Acids. | Guelzim N et al. | β | 2011 | β |
| Deletion of steroid receptor coactivator-3 gene ameliorates hepatic steatosis. | Ma X et al. | β | 2011 | β |
| Dietary medium-chain triglycerides attenuate hepatic lipid deposition in growing rats with protein malnutrition. | Kuwahata M et al. | β | 2011 | β |
| Dual acting and pan-PPAR activators as potential anti-diabetic therapies. | Heald M et al. | β | 2011 | β |
| Effects of Medicinal herb Extracts and their Components on Steatogenic Hepatotoxicity in Sk-hep1 Cells. | Choi YJ et al. | β | 2011 | β |
| Effects of the interaction of diabetes and iron supplementation on hepatic and pancreatic tissues, oxidative stress markers, and liver peroxisome proliferator-activated receptor-Ξ± expression. | Silva M et al. | β | 2011 | β |
| Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARΞ±-dependent and -independent pathways. | Goto T et al. | β | 2011 | β |
| Fatty acid synthase modulates homeostatic responses to myocardial stress. | Razani B et al. | β | 2011 | β |
| Fenofibrate, a peroxisome proliferator-activated receptor Ξ± agonist, alters triglyceride metabolism in enterocytes of mice. | Uchida A et al. | β | 2011 | β |
| FGF21 as an Endocrine Regulator in Lipid Metabolism: From Molecular Evolution to Physiology and Pathophysiology. | Murata Y et al. | β | 2011 | β |
| Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis. | Domouzoglou EM et al. | β | 2011 | β |
| Gene expression profile change and associated physiological and pathological effects in mouse liver induced by fasting and refeeding. | Zhang F et al. | β | 2011 | β |
| Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia. | Kulozik P et al. | β | 2011 | β |
| Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 expression in HepG2 cell line. | VilΓ -Brau A et al. | β | 2011 | β |
| Inhibition of gluconeogenic genes by calcium-regulated heat-stable protein 1 via repression of peroxisome proliferator-activated receptor Ξ±. | Fan Y et al. | β | 2011 | β |
| Intestinal gene expression in pigs: effects of reduced feed intake during weaning and potential impact of dietary components. | Bauer E et al. | β | 2011 | β |
| Lipid metabolism and body composition in Gclm(-/-) mice. | Kendig EL et al. | β | 2011 | β |
| Lipid-sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome. | Vacca M et al. | β | 2011 | β |
| Liver mitochondrial function and redox status in an experimental model of non-alcoholic fatty liver disease induced by monosodium L-glutamate in rats. | Lazarin Mde O et al. | β | 2011 | β |
| Low-Protein Diet during Lactation and Maternal Metabolism in Rats. | Moretto VL et al. | β | 2011 | β |
| Menin prevents liver steatosis through co-activation of peroxisome proliferator-activated receptor alpha. | Cheng P et al. | β | 2011 | β |
| Mitochondrial metabolic suppression in fasting and daily torpor: consequences for reactive oxygen species production. | Brown JC et al. | β | 2011 | β |
| Modeling disorders of fatty acid metabolism in the mouse. | Goetzman ES | β | 2011 | β |
| Mulberry extract inhibits oleic acid-induced lipid accumulation via reduction of lipogenesis and promotion of hepatic lipid clearance. | Ou TT et al. | β | 2011 | β |
| New insights into the role of PPARs. | Montagner A et al. | β | 2011 | β |
| Oxidative tissue: perilipin 5 links storage with the furnace. | Wang H et al. | β | 2011 | β |
| Peroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in mice. | Lalloyer F et al. | β | 2011 | β |
| Peroxisome proliferator-activated receptor {alpha} is responsible for the up-regulation of hepatic glucose-6-phosphatase gene expression in fasting and db/db Mice. | Im SS et al. | β | 2011 | β |
| Peroxisome proliferator-activated receptors and hepatitis C virus. | Eslam M et al. | β | 2011 | β |
| Peroxisome proliferator-activated receptor Ξ± (PPARΞ±) induces PPARΞ³ coactivator 1Ξ± (PGC-1Ξ±) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16. | Hondares E et al. | β | 2011 | β |
| Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms. | Iacono A et al. | β | 2011 | β |
| Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor alpha (PPARalpha) activity. | Gachon F et al. | β | 2011 | β |
| Rat liver uncoupling protein 2: changes induced by a fructose-rich diet. | Castro MC et al. | β | 2011 | β |
| Redox balance in the pathogenesis of nonalcoholic fatty liver disease: mechanisms and therapeutic opportunities. | Gambino R et al. | β | 2011 | β |
| Regular endurance exercise improves the diminished hepatic carnitine status in mice fed a high-fat diet. | Ringseis R et al. | β | 2011 | β |
| Regulation of genes involved in lipid metabolism by dietary oxidized fat. | Ringseis R et al. | β | 2011 | β |
| Review: Effects of PPAR activation in the placenta and the fetus: implications in maternal diabetes. | Jawerbaum A et al. | β | 2011 | β |
| Sex differences in nuclear receptor-regulated liver metabolic pathways. | Rando G et al. | β | 2011 | β |
| The genetics of brown adipocyte induction in white fat depots. | Kozak LP | β | 2011 | β |
| Tributyltin is a potent inhibitor of piscine peroxisome proliferator-activated receptor Ξ± and Ξ². | Colliar L et al. | β | 2011 | β |
| Ursolic acid is a PPAR-Ξ± agonist that regulates hepatic lipid metabolism. | Jia Y et al. | β | 2011 | β |
| VLDL hydrolysis by hepatic lipase regulates PPARΞ΄ transcriptional responses. | Brown JD et al. | β | 2011 | β |
| A comparative study of genome-wide transcriptional profiles of primary hepatocytes in collagen sandwich and monolayer cultures. | Kim Y et al. | β | 2010 | β |
| Adaptation of myocardial substrate metabolism to a ketogenic nutrient environment. | Wentz AE et al. | β | 2010 | β |
| Adipose differentiation-related protein regulates lipids and insulin in pancreatic islets. | Faleck DM et al. | β | 2010 | β |
| Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat. | Xie Z et al. | β | 2010 | β |
| A nonthiazolidinedione peroxisome proliferator-activated receptor Ξ±/Ξ³ dual agonist CG301360 alleviates insulin resistance and lipid dysregulation in db/db mice. | Jeong HW et al. | β | 2010 | β |
| Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice. | Kim SH et al. | β | 2010 | β |
| Brown fat thermogenesis and body weight regulation in mice: relevance to humans. | Kozak LP et al. | β | 2010 | β |
| Chronic prednisolone treatment reduces hepatic insulin sensitivity while perturbing the fed-to-fasting transition in mice. | Laskewitz AJ et al. | β | 2010 | β |
| Circadian dysfunction in disease. | Bechtold DA et al. | β | 2010 | β |
| Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells. | Nishimura-Sakurai Y et al. | β | 2010 | β |
| Conditional PPARΞ³ knockout from cardiomyocytes of adult mice impairs myocardial fatty acid utilization and cardiac function. | Luo J et al. | β | 2010 | β |
| Effect of diet supplementation on the expression of bovine genes associated with Fatty Acid synthesis and metabolism. | Joseph SJ et al. | β | 2010 | β |
| Endogenous ligands for nuclear receptors: digging deeper. | Schupp M et al. | β | 2010 | β |
| Eriobotrya japonica improves hyperlipidemia and reverses insulin resistance in high-fat-fed mice. | Shih CC et al. | β | 2010 | β |
| Fasting and sampling time affect liver gene expression of high-fat diet-fed mice. | Lee CY | β | 2010 | β |
| Fasting-induced oxidative stress in very long chain acyl-CoA dehydrogenase-deficient mice. | Tucci S et al. | β | 2010 | β |
| Fasting promotes the expression of SIRT1, an NAD+ -dependent protein deacetylase, via activation of PPARalpha in mice. | Hayashida S et al. | β | 2010 | β |
| Fatty liver: role of inflammation and fatty acid nutrition. | Byrne CD | β | 2010 | β |
| Gene expression in hypothalamus, liver, and adipose tissues and food intake response to melanocortin-4 receptor agonist in pigs expressing melanocortin-4 receptor mutations. | Barb CR et al. | β | 2010 | β |
| Genetic control of de novo lipogenesis: role in diet-induced obesity. | Strable MS et al. | β | 2010 | β |
| Genomics of metabolic adaptations in the peripartal cow. | Loor JJ | β | 2010 | β |
| Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism. | Martinez-Jimenez CP et al. | β | 2010 | β |
| High density lipoprotein turnover is dependent on peroxisome proliferator-activated receptor Ξ± in mice. | Akita N et al. | β | 2010 | β |
| Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease. | Itoh N | β | 2010 | β |
| IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. | Ricardo-Gonzalez RR et al. | β | 2010 | β |
| Interaction of the hepatitis C virus (HCV) core with cellular genes in the development of HCV-induced steatosis. | Khan M et al. | β | 2010 | β |
| Iron restriction improves type 2 diabetes mellitus in Otsuka Long-Evans Tokushima fatty rats. | Minamiyama Y et al. | β | 2010 | β |
| Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity. | Stienstra R et al. | β | 2010 | β |
| Liver fatty acid-binding protein and obesity. | Atshaves BP et al. | β | 2010 | β |
| Maternal overweight programs insulin and adiponectin signaling in the offspring. | Shankar K et al. | β | 2010 | β |
| MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis. | GrΓΈntved L et al. | β | 2010 | β |
| Molecular characterization of a gilthead sea bream (Sparus aurata) muscle tissue cDNA for carnitine palmitoyltransferase 1B (CPT1B). | Boukouvala E et al. | β | 2010 | β |
| Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation. | Bugge A et al. | β | 2010 | β |
| Mouse OCTN2 is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha) via a PPRE located in the first intron. | Wen G et al. | β | 2010 | β |
| Nuclear receptors as drug targets for metabolic disease. | Schulman IG | β | 2010 | β |
| Omega-3 long chain fatty acid synthesis is regulated more by substrate levels than gene expression. | Tu WC et al. | β | 2010 | β |
| Pathogenesis of alcoholic liver disease: the role of nuclear receptors. | Gyamfi MA et al. | β | 2010 | β |
| Peroxisome proliferator activated receptor alpha (PPARalpha) and PPAR gamma coactivator (PGC-1alpha) induce carnitine palmitoyltransferase IA (CPT-1A) via independent gene elements. | Song S et al. | β | 2010 | β |
| Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism. | Frigerio F et al. | β | 2010 | β |
| Peroxisome proliferator-activated receptor alpha target genes. | Rakhshandehroo M et al. | β | 2010 | β |
| Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) acts as regulator of metabolism linked to multiple cellular functions. | Wagner KD et al. | β | 2010 | β |
| Pharmacological and non-pharmacological treatment of non-alcoholic fatty liver disease. | Kaser S et al. | β | 2010 | β |
| Pharmacological effects of lipid-lowering drugs on circulating adipokines. | Wanders D et al. | β | 2010 | β |
| PPARalpha does not suppress muscle-associated gene expression in brown adipocytes but does influence expression of factors that fingerprint the brown adipocyte. | WaldΓ©n TB et al. | β | 2010 | β |
| PPARalpha: energy combustion, hypolipidemia, inflammation and cancer. | Pyper SR et al. | β | 2010 | β |
| PPAR modulation of kinase-linked receptor signaling in physiology and disease. | Rotman N et al. | β | 2010 | β |
| PPARs and adipocyte function. | Christodoulides C et al. | β | 2010 | β |
| PPARs: diverse regulators in energy metabolism and metabolic diseases. | Wang YX | β | 2010 | β |
| Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet. | Sunny NE et al. | β | 2010 | β |
| Regulation of Proteome Maintenance Gene Expression by Activators of Peroxisome Proliferator-Activated Receptor Ξ±. | Ren H et al. | β | 2010 | β |
| Role of PPARΞ± in Hepatic Carbohydrate Metabolism. | Peeters A et al. | β | 2010 | β |
| Sex-different hepaticglycogen content and glucose output in rats. | Gustavsson C et al. | β | 2010 | β |
| Suppression effects of AICAR on insulin secretion involved in peroxisome proliferator-activated receptor gamma changes in INS-1 cells. | Guo H et al. | β | 2010 | β |
| The genetics of brown adipose tissue. | Kozak LP et al. | β | 2010 | β |
| The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha. | Danno H et al. | β | 2010 | β |
| The role of peroxisome proliferator-activated receptor alpha in transcriptional regulation of novel organic cation transporters. | Eder K et al. | β | 2010 | β |
| The Role of PPARΞ± Activation in Liver and Muscle. | Burri L et al. | β | 2010 | β |
| Transcriptional profiling reveals divergent roles of PPARalpha and PPARbeta/delta in regulation of gene expression in mouse liver. | Sanderson LM et al. | β | 2010 | β |
| Unexpected effects of fasting on murine lipid homeostasis--transcriptomic and lipid profiling. | SokoloviΔ M et al. | β | 2010 | β |
| VLDL hydrolysis by LPL activates PPAR-alpha through generation of unbound fatty acids. | Ruby MA et al. | β | 2010 | β |
| Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. | Wang Q et al. | β | 2009 | β |
| Adenosine signaling contributes to ethanol-induced fatty liver in mice. | Peng Z et al. | β | 2009 | β |
| A minimal model for hepatic fatty acid balance during fasting: application to PPAR alpha-deficient mice. | Blavy P et al. | β | 2009 | β |
| Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy. | GΓΌrtl B et al. | β | 2009 | β |
| Carnitine synthesis and uptake into cells are stimulated by fasting in pigs as a model of nonproliferating species. | Ringseis R et al. | β | 2009 | β |
| Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. | Rakhshandehroo M et al. | β | 2009 | β |
| Dietary fat source affects metabolism of fatty acids in pigs as evaluated by altered expression of lipogenic genes in liver and adipose tissues. | Duran-MontgΓ© P et al. | β | 2009 | β |
| Differential regulation of peroxisome proliferator-activated receptor (PPAR)-alpha1 and truncated PPARalpha2 as an adaptive response to fasting in the control of hepatic peroxisomal fatty acid beta-oxidation in the hibernating mammal. | El Kebbaj Z et al. | β | 2009 | β |
| Dropping liver fat droplets. | Kersten S et al. | β | 2009 | β |
| Drosophila HNF4 regulates lipid mobilization and beta-oxidation. | Palanker L et al. | β | 2009 | β |
| Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. | Ishii H et al. | β | 2009 | β |
| Emerging roles of peroxisome proliferator-activated receptor-beta/delta in inflammation. | Bishop-Bailey D et al. | β | 2009 | β |
| Endocrine fibroblast growth factors as regulators of metabolic homeostasis. | Kurosu H et al. | β | 2009 | β |
| Ethanol and liver: recent advances in the mechanisms of ethanol-induced hepatosteatosis. | Zeng T et al. | β | 2009 | β |
| Fasting Upregulates PPARalpha Target Genes in Brain and Influences Pituitary Hormone Expression in a PPARalpha Dependent Manner. | KΓΆnig B et al. | β | 2009 | β |
| Fatty acid composition and development of hepatic lipidosis during food deprivation--mustelids as a potential animal model for liver steatosis. | Nieminen P et al. | β | 2009 | β |
| Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis, and elongation in mice. | Oosterveer MH et al. | β | 2009 | β |
| Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. | Hotta Y et al. | β | 2009 | β |
| Filling gaps in PPAR-alpha signaling through comparative nutrigenomics analysis. | Cavalieri D et al. | β | 2009 | β |
| Gene expression profiling in the liver and lung of perfluorooctane sulfonate-exposed mouse fetuses: comparison to changes induced by exposure to perfluorooctanoic acid. | Rosen MB et al. | β | 2009 | β |
| GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins. | Beigneux AP et al. | β | 2009 | β |
| GPIHBP1 and lipolysis: an update. | Beigneux AP et al. | β | 2009 | β |
| Hepatic lipid metabolism and non-alcoholic fatty liver disease. | Tessari P et al. | β | 2009 | β |
| Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. | Purushotham A et al. | β | 2009 | β |
| High-fat feeding in cardiomyocyte-restricted PPARdelta knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes. | Li Y et al. | β | 2009 | β |
| Human urinary metabolomic profile of PPARalpha induced fatty acid beta-oxidation. | Patterson AD et al. | β | 2009 | β |
| Hypoxia-inducible factor 2 regulates hepatic lipid metabolism. | Rankin EB et al. | β | 2009 | β |
| Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma. | Connors RV et al. | β | 2009 | β |
| Influence of conjugated linoleic acids on functional properties of vascular cells. | Ringseis R et al. | β | 2009 | β |
| Limited effects of fasting on hepatitis B virus (HBV) biosynthesis in HBV transgenic mice. | Li L et al. | β | 2009 | β |
| Liver fatty acid binding protein gene ablation enhances age-dependent weight gain in male mice. | Martin GG et al. | β | 2009 | β |
| Metabolic disturbances in non-alcoholic fatty liver disease. | Byrne CD et al. | β | 2009 | β |
| Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse. | Atherton HJ et al. | β | 2009 | β |
| Microarray gene expression profiles of fasting induced changes in liver and adipose tissues of pigs expressing the melanocortin-4 receptor D298N variant. | Lkhagvadorj S et al. | β | 2009 | β |
| Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis. | Miinalainen IJ et al. | β | 2009 | β |
| Molecular mechanisms of alcoholic fatty liver. | Purohit V et al. | β | 2009 | β |
| Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells. | Gutgesell A et al. | β | 2009 | β |
| Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model. | Savas Γ et al. | β | 2009 | β |
| Peroxisome proliferator-activated receptor-alpha modulates insulin gene transcription factors and inflammation in adipose tissues in mice. | Yessoufou A et al. | β | 2009 | β |
| Peroxisome proliferator-activated receptor-alpha (PPARalpha): at the crossroads of obesity, diabetes and cardiovascular disease. | Fruchart JC | β | 2009 | β |
| Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver. | Sanderson LM et al. | β | 2009 | β |
| PPARs and the cardiovascular system. | Hamblin M et al. | β | 2009 | β |
| Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats. | Esposito E et al. | β | 2009 | β |
| Protective effect of bicyclol on tetracycline-induced fatty liver in mice. | Yu HY et al. | β | 2009 | β |
| [Protein restriction in pregnancy: effects related to dam metabolism]. | Ballen ML et al. | β | 2009 | β |
| Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation. | Crawford PA et al. | β | 2009 | β |
| Regulation of the human SLC25A20 expression by peroxisome proliferator-activated receptor alpha in human hepatoblastoma cells. | Tachibana K et al. | β | 2009 | β |
| Response to carbohydrate and fat refeeding in the expression of genes involved in nutrient partitioning and metabolism: striking effects on fibroblast growth factor-21 induction. | SΓ‘nchez J et al. | β | 2009 | β |
| Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. | Tateishi K et al. | β | 2009 | β |
| Role of peroxisome proliferator-activated receptor-alpha in fasting-mediated oxidative stress. | Abdelmegeed MA et al. | β | 2009 | β |
| Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity. | Chen C et al. | β | 2009 | β |
| Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids. | Villanueva CJ et al. | β | 2009 | β |
| Starvation protects germline stem cells and extends reproductive longevity in C. elegans. | Angelo G et al. | β | 2009 | β |
| The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress. | Maglich JM et al. | β | 2009 | β |
| The Randle cycle revisited: a new head for an old hat. | Hue L et al. | β | 2009 | β |
| The regulation of acyl-CoA dehydrogenases in adipose tissue by rosiglitazone. | Goetzman ES | β | 2009 | β |
| The role of melanocortin neuronal pathways in circadian biology: a new homeostatic output involving melanocortin-3 receptors? | Begriche K et al. | β | 2009 | β |
| Thioredoxin binding protein-2/thioredoxin-interacting protein is a critical regulator of insulin secretion and peroxisome proliferator-activated receptor function. | Oka S et al. | β | 2009 | β |
| Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response. | Bouwens M et al. | β | 2008 | β |
| Alterations in carbohydrate metabolism and its regulation in PPARalpha null mouse hearts. | GΓ©linas R et al. | β | 2008 | β |
| A natural polymorphism in peroxisome proliferator-activated receptor-alpha hinge region attenuates transcription due to defective release of nuclear receptor corepressor from chromatin. | Liu MH et al. | β | 2008 | β |
| Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis. | Koufany M et al. | β | 2008 | β |
| Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver. | Oishi K et al. | β | 2008 | β |
| Effects of Momordica charantia on insulin resistance and visceral obesity in mice on high-fat diet. | Shih CC et al. | β | 2008 | β |
| Elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate composition. | Wang Y et al. | β | 2008 | β |
| Endocrine FGFs and Klothos: emerging concepts. | Kuro-o M | β | 2008 | β |
| Energy-responsive timekeeping. | Bechtold DA | β | 2008 | β |
| Fasting and caloric restriction increases mRNA concentrations of novel organic cation transporter-2 and carnitine concentrations in rat tissues. | Luci S et al. | β | 2008 | β |
| Gene expression in human NAFLD. | Greco D et al. | β | 2008 | β |
| Gene expression of nutrient transporters in the small intestine of chickens from lines divergently selected for high or low juvenile body weight. | Mott CR et al. | β | 2008 | β |
| Genome-wide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism. | Li S et al. | β | 2008 | β |
| Hexarelin Signaling to PPARgamma in Metabolic Diseases. | Demers A et al. | β | 2008 | β |
| Hypolipidaemic effects of fenofibrate and fasting in the herbivorous grass carp ( Ctenopharyngodon idella) fed a high-fat diet. | Du ZY et al. | β | 2008 | β |
| Inhibition of mitochondrial fatty acid oxidation in vivo only slightly suppresses gluconeogenesis but enhances clearance of glucose in mice. | Derks TG et al. | β | 2008 | β |
| Integration of metabolism and inflammation by lipid-activated nuclear receptors. | Bensinger SJ et al. | β | 2008 | β |
| Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish. | Cheshenko K et al. | β | 2008 | β |
| Liver fatty acid-binding protein gene-ablated female mice exhibit increased age-dependent obesity. | Martin GG et al. | β | 2008 | β |
| Long-term hypoxia modulates expression of key genes regulating adipose function in the late-gestation ovine fetus. | Myers DA et al. | β | 2008 | β |
| Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice. | Montgomery RL et al. | β | 2008 | β |
| Molecular mechanism of age-specific hepatic lipid accumulation in PPARalpha (+/-):LDLR (+/-) mice, an obese mouse model. | Li Y et al. | β | 2008 | β |
| Molecular mechanisms of the antiproliferative effect of beraprost, a prostacyclin agonist, in murine vascular smooth muscle cells. | Lin H et al. | β | 2008 | β |
| Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha. | KΓΆnig B et al. | β | 2008 | β |
| Nuclear receptor cofactor receptor interacting protein 140 controls hepatic triglyceride metabolism during wasting in mice. | Berriel Diaz M et al. | β | 2008 | β |
| Nuclear receptors, mitochondria and lipid metabolism. | Alaynick WA | β | 2008 | β |
| Peroxisome proliferator-activated receptor alpha agonist-induced down-regulation of hepatic glucocorticoid receptor expression in SD rats. | Chen X et al. | β | 2008 | β |
| Peroxisome proliferator-activated receptor alpha deficiency abolishes the response of lipogenic gene expression to re-feeding: restoration of the normal response by activation of liver X receptor alpha. | Hebbachi AM et al. | β | 2008 | β |
| Peroxisome proliferator activated receptors and lipoprotein metabolism. | Kersten S | β | 2008 | β |
| Peroxisome proliferator-activated receptors and the metabolic syndrome. | Bragt MC et al. | β | 2008 | β |
| PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis. | Barish GD et al. | β | 2008 | β |
| Role of fatty acid binding proteins and long chain fatty acids in modulating nuclear receptors and gene transcription. | Schroeder F et al. | β | 2008 | β |
| Role of peroxisome-proliferator-activated receptor beta/delta (PPARbeta/delta) in gastrointestinal tract function and disease. | Peters JM et al. | β | 2008 | β |
| Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease. | Kallwitz ER et al. | β | 2008 | β |
| Sequential changes in the expression of genes involved in lipid metabolism in adipose tissue and liver in response to fasting. | Palou M et al. | β | 2008 | β |
| The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. | Davies BS et al. | β | 2008 | β |
| The glucagon receptor is required for the adaptive metabolic response to fasting. | Longuet C et al. | β | 2008 | β |
| The glucocorticoid receptor controls hepatic dyslipidemia through Hes1. | Lemke U et al. | β | 2008 | β |
| The interplay of prolactin and the glucocorticoids in the regulation of beta-cell gene expression, fatty acid oxidation, and glucose-stimulated insulin secretion: implications for carbohydrate metabolism in pregnancy. | Arumugam R et al. | β | 2008 | β |
| The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis. | Reilly SJ et al. | β | 2008 | β |
| The PPAR trio: regulators of myocardial energy metabolism in health and disease. | Madrazo JA et al. | β | 2008 | β |
| Transcriptional regulation of hepatic fatty acid metabolism. | Guillou H et al. | β | 2008 | β |
| Transcriptome profiling of the feeding-to-fasting transition in chicken liver. | DΓ©sert C et al. | β | 2008 | β |
| Uncoupling protein-2 modulates the lipid metabolic response to fasting in mice. | Sheets AR et al. | β | 2008 | β |
| Adipose tissue integrity as a prerequisite for systemic energy balance: a critical role for peroxisome proliferator-activated receptor gamma. | Anghel SI et al. | β | 2007 | β |
| A growth hormone-releasing peptide promotes mitochondrial biogenesis and a fat burning-like phenotype through scavenger receptor CD36 in white adipocytes. | Rodrigue-Way A et al. | β | 2007 | β |
| A light- and electron-microscope study of hepatocytes of rats fed different diets. | Eagles DA et al. | β | 2007 | β |
| An afferent vagal nerve pathway links hepatic PPARalpha activation to glucocorticoid-induced insulin resistance and hypertension. | Bernal-Mizrachi C et al. | β | 2007 | β |
| Animal models for human risk assessment: the peroxisome proliferator-activated receptor alpha-humanized mouse. | Gonzalez FJ | β | 2007 | β |
| A novel peroxisome proliferator-activated receptor responsive element-luciferase reporter mouse reveals gender specificity of peroxisome proliferator-activated receptor activity in liver. | Ciana P et al. | β | 2007 | β |
| Beyond lipids, pharmacological PPARalpha activation has important effects on amino acid metabolism as studied in the rat. | Sheikh K et al. | β | 2007 | β |
| Changes in liver PPARalpha mRNA expression in response to two levels of high-safflower-oil diets correlate with changes in adiposity and serum leptin in rats and mice. | Hsu SC et al. | β | 2007 | β |
| Clustering time-series gene expression data using smoothing spline derivatives. | DΓ©jean S et al. | β | 2007 | β |
| Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling. | Rakhshandehroo M et al. | β | 2007 | β |
| Conditional animal models for the study of lipid metabolism and lipid disorders. | Bock HH et al. | β | 2007 | β |
| Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. | Burgess SC et al. | β | 2007 | β |
| Dehydroepiandrosterone up-regulates the Adrenoleukodystrophy-related gene (ABCD2) independently of PPARalpha in rodents. | Gueugnon F et al. | β | 2007 | β |
| Dietary oxidised fat up regulates the expression of organic cation transporters in liver and small intestine and alters carnitine concentrations in liver, muscle and plasma of rats. | Koch A et al. | β | 2007 | β |
| Dietary palatinose and oleic acid ameliorate disorders of glucose and lipid metabolism in Zucker fatty rats. | Sato K et al. | β | 2007 | β |
| Dual subcellular localization in the endoplasmic reticulum and peroxisomes and a vital role in protecting against oxidative stress of fatty aldehyde dehydrogenase are achieved by alternative splicing. | Ashibe B et al. | β | 2007 | β |
| Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes. | Rozema DB et al. | β | 2007 | β |
| Effect of placental fatty acid metabolism and regulation by peroxisome proliferator activated receptor on pregnancy and fetal outcomes. | Xu Y et al. | β | 2007 | β |
| Effects of clofibrate treatment in laying hens. | KΓΆnig B et al. | β | 2007 | β |
| Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. | Inagaki T et al. | β | 2007 | β |
| FABPs as determinants of myocellular and hepatic fuel metabolism. | Binas B et al. | β | 2007 | β |
| Fasting-induced increases in aquaporin 7 and adipose triglyceride lipase mRNA expression in adipose tissue are attenuated by peroxisome proliferator-activated receptor alpha deficiency. | Walker CG et al. | β | 2007 | β |
| Fasting induces a biphasic adaptive metabolic response in murine small intestine. | SokoloviΔ M et al. | β | 2007 | β |
| Fasting induces changes in peripheral blood mononuclear cell gene expression profiles related to increases in fatty acid beta-oxidation: functional role of peroxisome proliferator activated receptor alpha in human peripheral blood mononuclear cells. | Bouwens M et al. | β | 2007 | β |
| Fatty acid-induced effect on glucagon secretion is mediated via fatty acid oxidation. | Hong J et al. | β | 2007 | β |
| FGF21: a missing link in the biology of fasting. | Reitman ML | β | 2007 | β |
| Fibrates upregulate TRB3 in lymphocytes independent of PPAR alpha by augmenting CCAAT/enhancer-binding protein beta (C/EBP beta) expression. | Selim E et al. | β | 2007 | β |
| Food entrainment of circadian gene expression altered in PPARalpha-/- brown fat and heart. | Goh BC et al. | β | 2007 | β |
| Four weeks one-leg training and high fat diet does not alter PPARalpha protein or mRNA expression in human skeletal muscle. | Helge JW et al. | β | 2007 | β |
| Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting. | van den Bosch HM et al. | β | 2007 | β |
| Gene expression profiling in livers of mice after acute inhibition of beta-oxidation. | van der Leij FR et al. | β | 2007 | β |
| Gene expression profiling in the lung and liver of PFOA-exposed mouse fetuses. | Rosen MB et al. | β | 2007 | β |
| Gene expression profiling of rat liver treated with serum triglyceride-decreasing compounds. | Omura K et al. | β | 2007 | β |
| Genetic manipulations of PPARs: effects on obesity and metabolic disease. | Barak Y et al. | β | 2007 | β |
| Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat. | Xue B et al. | β | 2007 | β |
| Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors. | Mandard S et al. | β | 2007 | β |
| Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. | Badman MK et al. | β | 2007 | β |
| Hepatic gene expression and lipid parameters in complement C3(-/-) mice that do not develop ethanol-induced steatosis. | Bykov I et al. | β | 2007 | β |
| Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. | Miyazaki M et al. | β | 2007 | β |
| Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma. | Kim KH et al. | β | 2007 | β |
| Importance of PPAR alpha for the effects of growth hormone on hepatic lipid and lipoprotein metabolism. | Ljungberg A et al. | β | 2007 | β |
| In appreciation of Sir Philip Randle: the glucose-fatty acid cycle. | Sugden MC | β | 2007 | β |
| Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences. | Leclercq IA et al. | β | 2007 | β |
| Lipopolysaccharide induces adipose differentiation-related protein expression and lipid accumulation in the liver through inhibition of fatty acid oxidation in mice. | Ohhira M et al. | β | 2007 | β |
| LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues. | Dalen KT et al. | β | 2007 | β |
| Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity. | Vaquero J et al. | β | 2007 | β |
| mRNA levels of peroxisome proliferator-activated receptors and their coactivators are affected by glucose deprivation and oleate in human hepatoma hepG2 cells. | Bogdanova K et al. | β | 2007 | β |
| New therapeutic target for metabolic syndrome: PPARdelta. | Takahashi S et al. | β | 2007 | β |
| Nuclear receptor binding to the retinoic acid response elements of the phosphoenolpyruvate carboxykinase gene in vivo: effects of vitamin A deficiency. | Scribner KB et al. | β | 2007 | β |
| Omega 3 - Omega 6: What is right for the liver? | El-Badry AM et al. | β | 2007 | β |
| Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis. | Villena JA et al. | β | 2007 | β |
| Peroxisome proliferator-activated receptor alpha polymorphisms and postprandial lipemia in healthy men. | Tanaka T et al. | β | 2007 | β |
| Peroxisome proliferator-activated receptor-delta, a regulator of oxidative capacity, fuel switching and cholesterol transport. | FΓΌrnsinn C et al. | β | 2007 | β |
| Peroxisome proliferator-activated receptors as molecular targets in relation to obesity and type 2 diabetes. | Seda O et al. | β | 2007 | β |
| Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. | Brown JD et al. | β | 2007 | β |
| PPAR agonists: multimodal drugs for the treatment of type-2 diabetes. | Gross B et al. | β | 2007 | β |
| PPAR alpha-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation. | van Vlies N et al. | β | 2007 | β |
| PPARalpha-dependent induction of the energy homeostasis-regulating nuclear receptor NR1i3 (CAR) in rat hepatocytes: potential role in starvation adaptation. | Wieneke N et al. | β | 2007 | β |
| PPARalpha is a key regulator of hepatic FGF21. | LundΓ₯sen T et al. | β | 2007 | β |
| PPARalpha protects proximal tubular cells from acute fatty acid toxicity. | Kamijo Y et al. | β | 2007 | β |
| PPAR delta agonists and metabolic diseases. | Kang K et al. | β | 2007 | β |
| PPARs and their metabolic modulation: new mechanisms for transcriptional regulation? | Ahmed W et al. | β | 2007 | β |
| PPARs in Calorie Restricted and Genetically Long-Lived Mice. | Masternak MM et al. | β | 2007 | β |
| PPARs in the Control of Uncoupling Proteins Gene Expression. | Villarroya F et al. | β | 2007 | β |
| PPARs, Obesity, and Inflammation. | Stienstra R et al. | β | 2007 | β |
| Role of hormone-sensitive lipase in beta-adrenergic remodeling of white adipose tissue. | Mottillo EP et al. | β | 2007 | β |
| Roles of PPARs on regulating myocardial energy and lipid homeostasis. | Yang Q et al. | β | 2007 | β |
| RXR: from partnership to leadership in metabolic regulations. | Desvergne B | β | 2007 | β |
| The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. | Guo F et al. | β | 2007 | β |
| Vitamin A regulation of gene expression: molecular mechanism of a prototype gene. | McGrane MM | β | 2007 | β |
| Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor alpha. | Park CW et al. | β | 2006 | β |
| A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-alpha null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome. | Atherton HJ et al. | β | 2006 | β |
| Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. | Yoon MJ et al. | β | 2006 | β |
| Alcohol and lipid metabolism. | Crabb DW et al. | β | 2006 | β |
| A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. | Zhou J et al. | β | 2006 | β |
| Apolipoprotein A-IV is regulated by nutritional and metabolic stress: involvement of glucocorticoids, HNF-4 alpha, and PGC-1 alpha. | Hanniman EA et al. | β | 2006 | β |
| Developmental and tissue-specific involvement of peroxisome proliferator-activated receptor-alpha in the control of mouse uncoupling protein-3 gene expression. | Pedraza N et al. | β | 2006 | β |
| Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice. | Burgess SC et al. | β | 2006 | β |
| Effects of PPARalpha on cardiac glucose metabolism: a transcriptional equivalent of the glucose-fatty acid cycle? | Finck BN | β | 2006 | β |
| Gender-related response of lipid metabolism to dietary fatty acids in the hamster. | Morise A et al. | β | 2006 | β |
| Haploinsufficiency in the PPARalpha and LDL receptor genes leads to gender- and age-specific obesity and hyperinsulinemia. | Sugiyama E et al. | β | 2006 | β |
| Hepatic gene expression profile of lipid metabolism in rats: Impact of caloric restriction and growth hormone/insulin-like growth factor-1 suppression. | Higami Y et al. | β | 2006 | β |
| Induction of intestinal peptide transporter 1 expression during fasting is mediated via peroxisome proliferator-activated receptor alpha. | Shimakura J et al. | β | 2006 | β |
| Inhibition of matrix metalloproteinases increases PPAR-alpha and IL-6 and prevents dietary-induced hepatic steatosis and injury in a murine model. | Alwayn IP et al. | β | 2006 | β |
| International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. | Michalik L et al. | β | 2006 | β |
| Investigational PPAR-gamma agonists for the treatment of Type 2 diabetes. | Savkur RS et al. | β | 2006 | β |
| Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. | Finck BN et al. | β | 2006 | β |
| Mechanisms for the hypotriglyceridemic effect of marine omega-3 fatty acids. | Davidson MH | β | 2006 | β |
| MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha. | Yamaguchi T et al. | β | 2006 | β |
| Nuclear receptor expression links the circadian clock to metabolism. | Yang X et al. | β | 2006 | β |
| Nuclear receptor mediated gene regulation through chromatin remodeling and histone modifications. | Kishimoto M et al. | β | 2006 | β |
| Nutrigenomics: from molecular nutrition to prevention of disease. | Afman L et al. | β | 2006 | β |
| Peroxisome proliferator-activated receptor-alpha and glucocorticoids interactively regulate insulin secretion during pregnancy. | Holness MJ et al. | β | 2006 | β |
| Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets. | Lalloyer F et al. | β | 2006 | β |
| Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain. | Knauf C et al. | β | 2006 | β |
| Peroxisome proliferator-activated receptor delta (PPARdelta), a novel target site for drug discovery in metabolic syndrome. | Takahashi S et al. | β | 2006 | β |
| Peroxisome proliferator-activated receptors: bridging metabolic syndrome with molecular nutrition. | Guri AJ et al. | β | 2006 | β |
| PPARalpha agonists up-regulate organic cation transporters in rat liver cells. | Luci S et al. | β | 2006 | β |
| Prevention of adipose tissue depletion during food deprivation in angiotensin type 2 receptor-deficient mice. | Yvan-Charvet L et al. | β | 2006 | β |
| Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. | Newberry EP et al. | β | 2006 | β |
| Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock. | Canaple L et al. | β | 2006 | β |
| Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis. | Shibata N et al. | β | 2006 | β |
| Regulatory circuits controlling white versus brown adipocyte differentiation. | Hansen JB et al. | β | 2006 | β |
| Signalling mechanisms linking hepatic glucose and lipid metabolism. | Weickert MO et al. | β | 2006 | β |
| Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. | Lefebvre P et al. | β | 2006 | β |
| Targeting components of the stress system as potential therapies for the metabolic syndrome: the peroxisome-proliferator-activated receptors. | Yumuk VD | β | 2006 | β |
| The effects of feed restriction on plasma biochemistry in growing meat type chickens (Gallus gallus). | Rajman M et al. | β | 2006 | β |
| Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice. | De Souza AT et al. | β | 2006 | β |
| Transcriptional regulation of metabolism. | Desvergne B et al. | β | 2006 | β |