How stem cells age and why this makes us grow old.
paper
Cited
Public
Unavailable
- Authors
- Sharpless, Norman E; DePinho, Ronald A
- Year
- 2007
- Journal
- Nature reviews. Molecular cell biology
- PMID
- 17717515
- DOI
- 10.1038/nrm2241
Recent data suggest that we age, in part, because our self-renewing stem cells grow old as a result of heritable intrinsic events, such as DNA damage, as well as extrinsic forces, such as changes in their supporting niches. Mechanisms that suppress the development of cancer, such as senescence and apoptosis, which rely on telomere shortening and the activities of p53 and p16(INK4a), may also induce an unwanted consequence: a decline in the replicative function of certain stem-cell types with advancing age. This decreased regenerative capacity appears to contribute to some aspects of mammalian ageing, with new findings pointing to a 'stem-cell hypothesis' for human age-associated conditions such as frailty, atherosclerosis and type 2 diabetes.
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| Differential Proteomic Analysis of Human Placenta-Derived Mesenchymal Stem Cells Cultured on Normal Tissue Culture Surface and Hyaluronan-Coated Surface. | Wong TY et al. | β | 2016 | β |
| Do DNA Double-Strand Breaks Drive Aging? | White RR et al. | β | 2016 | β |
| Examining how p16(INK4a) expression levels are linked to handgrip strength in the elderly. | Kao TW et al. | β | 2016 | β |
| Extracellular superoxide dismutase deficiency impairs wound healing in advanced age by reducing neovascularization and fibroblast function. | Fujiwara T et al. | β | 2016 | β |
| From restoration to regeneration: periodontal aging and opportunities for therapeutic intervention. | Huang L et al. | β | 2016 | β |
| Gene Transfection of Human Turbinate Mesenchymal Stromal Cells Derived from Human Inferior Turbinate Tissues. | Kwon JS et al. | β | 2016 | β |
| Hutchinson-Gilford progeria syndrome as a model for vascular aging. | Brassard JA et al. | β | 2016 | β |
| Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency: The role of DREAM in the maintenance of hESCs. | FontΓ‘n-Lozano A et al. | β | 2016 | β |
| Influence of Ageing on Tendon Homeostasis. | Birch HL et al. | β | 2016 | β |
| Interfering EZH2 Expression Reverses the Cisplatin Resistance in Human Ovarian Cancer by Inhibiting Autophagy. | Sun Y et al. | β | 2016 | β |
| LIN28A enhances the therapeutic potential of cultured neural stem cells in a Parkinson's disease model. | Rhee YH et al. | β | 2016 | β |
| New Insights Into the Role of RNA-Binding Proteins in the Regulation of Heart Development. | Ladd AN | β | 2016 | β |
| Nutrition and lifestyle in healthy aging: the telomerase challenge. | Boccardi V et al. | β | 2016 | β |
| Old cells, new tricks: chromatin structure in senescence. | Parry AJ et al. | β | 2016 | β |
| p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. | Adriaens C et al. | β | 2016 | β |
| Post Processing and Biological Evaluation of the Titanium Scaffolds for Bone Tissue Engineering. | Wysocki B et al. | β | 2016 | β |
| Potential drawbacks in cell-assisted lipotransfer: A systematic review of existing reports (Review). | Huang S et al. | β | 2016 | β |
| Qualifying stem cell sources: how to overcome potential pitfalls in regenerative medicine? | Reinke S et al. | β | 2016 | β |
| Regenerative decline of stem cells in sarcopenia. | Sousa-Victor P et al. | β | 2016 | β |
| Role of senescence marker p16 INK4a measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults. | Pustavoitau A et al. | β | 2016 | β |
| Senescence-Associated MCP-1 Secretion Is Dependent on a Decline in BMI1 in Human Mesenchymal Stromal Cells. | Jin HJ et al. | β | 2016 | β |
| SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair. | Vazquez BN et al. | β | 2016 | β |
| Stem Cells in Wound Healing: The Future of Regenerative Medicine? A Mini-Review. | Duscher D et al. | β | 2016 | β |
| Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases. | BΓ€r C et al. | β | 2016 | β |
| The role of hydrogen sulfide in aging and age-related pathologies. | Perridon BW et al. | β | 2016 | β |
| The Roles of the Stem Cell-Controlling Sox2 Transcription Factor: from Neuroectoderm Development to Alzheimer's Disease? | Sarlak G et al. | β | 2016 | β |
| Ultraviolet Radiation-Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging. | Panich U et al. | β | 2016 | β |
| Update on acute myeloid leukemia stem cells: New discoveries and therapeutic opportunities. | Stahl M et al. | β | 2016 | β |
| Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice. | Sato S et al. | β | 2015 | β |
| Adult human neural stem cell therapeutics: Current developmental status and prospect. | Nam H et al. | β | 2015 | β |
| Biomolecular bases of the senescence process and cancer. A new approach to oncological treatment linked to ageing. | Badiola I et al. | β | 2015 | β |
| Bone Marrow Stress Decreases Osteogenic Progenitors. | Ng AH et al. | β | 2015 | β |
| Cancer Microenvironment: What Can We Learn from the Stem Cell Niche. | Lacina L et al. | β | 2015 | β |
| Cardiac aging - Getting to the stem of the problem. | Hariharan N et al. | β | 2015 | β |
| CD49f Acts as an Inflammation Sensor to Regulate Differentiation, Adhesion, and Migration of Human Mesenchymal Stem Cells. | Yang Z et al. | β | 2015 | β |
| Does the maternal age affect the mesenchymal stem cell markers and gene expression in the human placenta? What is the evidence? | Alrefaei GI et al. | β | 2015 | β |
| Dysregulation of the Bmi-1/p16(Inkβ΄a) pathway provokes an aging-associated decline of submandibular gland function. | Yamakoshi K et al. | β | 2015 | β |
| Fetal microchimerism and maternal health: a review and evolutionary analysis of cooperation and conflict beyond the womb. | Boddy AM et al. | β | 2015 | β |
| Forging a signature of in vivo senescence. | Sharpless NE et al. | β | 2015 | β |
| Health Span-Extending Activity of Human Amniotic Membrane- and Adipose Tissue-Derived Stem Cells in F344 Rats. | Kim D et al. | β | 2015 | β |
| iPSCs as a major opportunity to understand and cure age-related diseases. | Lemey C et al. | β | 2015 | β |
| Klotho, stem cells, and aging. | Bian A et al. | β | 2015 | β |
| Lower Oncogenic Potential of Human Mesenchymal Stem Cells Derived from Cord Blood Compared to Induced Pluripotent Stem Cells. | Foroutan T et al. | β | 2015 | β |
| Mechanisms linking mtDNA damage and aging. | Pinto M et al. | β | 2015 | β |
| Minimizing second cancer risk following radiotherapy: current perspectives. | Ng J et al. | β | 2015 | β |
| Molecular differences between stromal cell populations from deciduous and permanent human teeth. | Kaukua N et al. | β | 2015 | β |
| Molecular mechanism of extrinsic factors affecting anti-aging of stem cells. | Wong TY et al. | β | 2015 | β |
| Muscle stem cell aging: regulation and rejuvenation. | Sousa-Victor P et al. | β | 2015 | β |
| Nutraceutical intervention reverses the negative effects of blood from aged rats on stem cells. | Bickford PC et al. | β | 2015 | β |
| Persistent Ξ³H2AX: A promising molecular marker of DNA damage and aging. | Siddiqui MS et al. | β | 2015 | β |
| Profiling of Sox4-dependent transcriptome in skin links tumour suppression and adult stem cell activation. | Foronda M et al. | β | 2015 | β |
| RAC3 more than a nuclear receptor coactivator: a key inhibitor of senescence that is downregulated in aging. | FernΓ‘ndez Larrosa PN et al. | β | 2015 | β |
| Reversible regulation of stem cell niche size associated with dietary control of Notch signalling. | Bonfini A et al. | β | 2015 | β |
| Short telomere length is associated with arterial aging in patients with type 2 diabetes mellitus. | Dudinskaya EN et al. | β | 2015 | β |
| SIRT1 activation rescues doxorubicin-induced loss of functional competence of human cardiac progenitor cells. | De Angelis A et al. | β | 2015 | β |
| Stem cells and aberrant signaling of molecular systems in skin aging. | Peng Y et al. | β | 2015 | β |
| Suppression of IGF-I signals in neural stem cells enhances neurogenesis and olfactory function during aging. | Chaker Z et al. | β | 2015 | β |
| Systemic impact molds mesenchymal stromal/stem cell aging. | Reitinger S et al. | β | 2015 | β |
| The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration. | Hesse RG et al. | β | 2015 | β |
| The Intricate Interplay between Mechanisms Underlying Aging and Cancer. | Piano A et al. | β | 2015 | β |
| The role of Pin1 protein in aging of human tendon stem/progenitor cells. | Chen L et al. | β | 2015 | β |
| Adipogenic differentiation is impaired in replicative senescent human subcutaneous adipose-derived stromal/progenitor cells. | Mitterberger MC et al. | β | 2014 | β |
| Anti-senescence efficacy of radio-electric asymmetric conveyer technology. | Maioli M et al. | β | 2014 | β |
| Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations. | Sakaguchi A et al. | β | 2014 | β |
| Caloric restriction and aging stem cells: the stick and the carrot? | Mazzoccoli G et al. | β | 2014 | β |
| Cellular aging in depression: Permanent imprint or reversible process?: An overview of the current evidence, mechanistic pathways, and targets for interventions. | Verhoeven JE et al. | β | 2014 | β |
| Cellular polarity in aging: role of redox regulation and nutrition. | Soares H et al. | β | 2014 | β |
| Cellular senescence: from physiology to pathology. | MuΓ±oz-EspΓn D et al. | β | 2014 | β |
| Change in peripheral blood leukocyte telomere length and mortality in breast cancer survivors. | Duggan C et al. | β | 2014 | β |
| Changes in the frequencies of human hematopoietic stem and progenitor cells with age and site. | Farrell TL et al. | β | 2014 | β |
| Characterization of adipose-derived stem cells of anatomical region from mice. | Luna AC et al. | β | 2014 | β |
| Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing. | Greaves LC et al. | β | 2014 | β |
| Debra-mediated Ci degradation controls tissue homeostasis in Drosophila adult midgut. | Li Z et al. | β | 2014 | β |
| Defining the toxicology of aging. | Sorrentino JA et al. | β | 2014 | β |
| DNA methylation, ageing and the influence of early life nutrition. | Lillycrop KA et al. | β | 2014 | β |
| Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer. | Sanoff HK et al. | β | 2014 | β |
| Enhancing spontaneous stem cell healing (Review). | Maguire G et al. | β | 2014 | β |
| Exonuclease 1 is essential for maintaining genomic stability and the proliferative capacity of neural but not hematopoietic stem cells. | Zhang J et al. | β | 2014 | β |
| Four pairs of gene-gene interactions associated with increased risk for type 2 diabetes (CDKN2BAS-KCNJ11), obesity (SLC2A9-IGF2BP2, FTO-APOA5), and hypertension (MC4R-IGF2BP2) in Chinese women. | Wang MH et al. | β | 2014 | β |
| Hematopoietic stem cells: do they have a role in keloid pathogenesis? | Bakry OA et al. | β | 2014 | β |
| Human stem cell aging: do mitochondrial DNA mutations have a causal role? | Baines HL et al. | β | 2014 | β |
| Immunohistochemical study of melanocyte-melanocyte stem cell lineage in vitiligo; a clue to interfollicular melanocyte stem cell reservoir. | Seleit I et al. | β | 2014 | β |
| Inside and out: the activities of senescence in cancer. | PΓ©rez-Mancera PA et al. | β | 2014 | β |
| Klotho deficiency disrupts hematopoietic stem cell development and erythropoiesis. | Vadakke Madathil S et al. | β | 2014 | β |
| Krebs cycle intermediates regulate DNA and histone methylation: epigenetic impact on the aging process. | Salminen A et al. | β | 2014 | β |
| Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung. | Nyunoya T et al. | β | 2014 | β |
| Proteostasis and aging of stem cells. | Vilchez D et al. | β | 2014 | β |
| Senescence in adipose-derived stem cells and its implications in nerve regeneration. | Mantovani C et al. | β | 2014 | β |
| Smurf2 regulates hematopoietic stem cell self-renewal and aging. | Ramkumar C et al. | β | 2014 | β |
| Somatic cells with a heavy mitochondrial DNA mutational load render induced pluripotent stem cells with distinct differentiation defects. | Wahlestedt M et al. | β | 2014 | β |
| Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation. | Foronda M et al. | β | 2014 | β |
| Splenectomy in trauma patients is associated with an increased risk of postoperative type II diabetes: a nationwide population-based study. | Wu SC et al. | β | 2014 | β |
| Stem cells as vehicles for youthful regeneration of aged tissues. | Rando TA et al. | β | 2014 | β |
| Stem cells: the pursuit of genomic stability. | Wyles SP et al. | β | 2014 | β |
| Surviving change: the metabolic journey of hematopoietic stem cells. | Kohli L et al. | β | 2014 | β |
| Systems biology approach to identify alterations in the stem cell reservoir of subcutaneous adipose tissue in a rat model of diabetes: effects on differentiation potential and function. | Ferrer-Lorente R et al. | β | 2014 | β |
| Targeting self-renewal in high-grade brain tumors leads to loss of brain tumor stem cells and prolonged survival. | Zhu Z et al. | β | 2014 | β |
| Telomerase as a "stemness" enzyme. | Kong F et al. | β | 2014 | β |
| Telomere dysfunction suppresses multiple endocrine neoplasia in mice. | Lee JH et al. | β | 2014 | β |
| The current landscape of adipose-derived stem cells in clinical applications. | Lim MH et al. | β | 2014 | β |
| The mitochondrial genome in aging and senescence. | Lauri A et al. | β | 2014 | β |
| The promise of perfect adult tissue repair and regeneration in mammals: Learning from regenerative amphibians and fish. | Godwin J | β | 2014 | β |
| The rejuvenation of aged stem cells for cardiac repair. | Ludke A et al. | β | 2014 | β |
| The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulators. | de Castro A et al. | β | 2014 | β |
| The telomeric sync model of speciation: species-wide telomere erosion triggers cycles of transposon-mediated genomic rearrangements, which underlie the saltatory appearance of nonadaptive characters. | Stindl R | β | 2014 | β |
| Age-associated changes in the ecological niche: implications for mesenchymal stem cell aging. | Asumda FZ | β | 2013 | β |
| Age-dependent transition from cell-level to population-level control in murine intestinal homeostasis revealed by coalescence analysis. | Hu Z et al. | β | 2013 | β |
| Aging epigenetics: causes and consequences. | Huidobro C et al. | β | 2013 | β |
| Aging is associated with highly defined epigenetic changes in the human epidermis. | Raddatz G et al. | β | 2013 | β |
| An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state. | Wahlestedt M et al. | β | 2013 | β |
| A strategy for highly selective detection and imaging of hypochlorite using selenoxide elimination. | Li G et al. | β | 2013 | β |
| Basic biology of skeletal aging: role of stress response pathways. | Almeida M et al. | β | 2013 | β |
| Biochemical markers of aging for longitudinal studies in humans. | Engelfriet PM et al. | β | 2013 | β |
| Cardiac stem cell senescence. | Cesselli D et al. | β | 2013 | β |
| Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair. | Cho JS et al. | β | 2013 | β |
| Cell senescence as both a dynamic and a static phenotype. | Young AR et al. | β | 2013 | β |
| Contemporary role of medical genetics in internal medicine. | Saracyn M et al. | β | 2013 | β |
| Culturing on Wharton's jelly extract delays mesenchymal stem cell senescence through p53 and p16INK4a/pRb pathways. | Hao H et al. | β | 2013 | β |
| Death by transposition - the enemy within? | Sedivy JM et al. | β | 2013 | β |
| Detection of label-free H2O2 based on sensitive Au nanorods as sensor. | Shan G et al. | β | 2013 | β |
| DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions. | Insinga A et al. | β | 2013 | β |
| Effects of melatonin on nervous system aging: neurogenesis and neurodegeneration. | Sarlak G et al. | β | 2013 | β |
| Fission yeast does not age under favorable conditions, but does so after stress. | Coelho M et al. | β | 2013 | β |
| Frailty and protein-energy wasting in elderly patients with end stage kidney disease. | Kim JC et al. | β | 2013 | β |
| 'From death, lead me to immortality' - mantra of ageing skeletal muscle. | Saini A et al. | β | 2013 | β |
| Functional dysregulation of stem cells during aging: a focus on skeletal muscle stem cells. | GarcΓa-Prat L et al. | β | 2013 | β |
| Human adipose-derived stem cells cultured in keratinocyte serum free medium: Donor's age does not affect the proliferation and differentiation capacities. | Ding DC et al. | β | 2013 | β |
| Implications of multipotent mesenchymal stromal cell aging. | Stochaj U et al. | β | 2013 | β |
| Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging. | GonzΓ‘lez-Navarro H et al. | β | 2013 | β |
| Increased telomere length and proliferative potential in peripheral blood mononuclear cells of adults of different ages stimulated with concanavalin A. | Murillo-Ortiz B et al. | β | 2013 | β |
| In serum veritas-in serum sanitas? Cell non-autonomous aging compromises differentiation and survival of mesenchymal stromal cells via the oxidative stress pathway. | Geissler S et al. | β | 2013 | β |
| Is cancer incidence decreased in the frail elderly? Evidence from a prospective cohort study. | Kanapuru B et al. | β | 2013 | β |
| Maintenance of genomic stability in mouse embryonic stem cells: relevance in aging and disease. | Giachino C et al. | β | 2013 | β |
| Making sense in antisense: therapeutic potential of noncoding RNAs in diabetes-induced vascular dysfunction. | Eken SM et al. | β | 2013 | β |
| Mechanisms that regulate stem cell aging and life span. | Signer RA et al. | β | 2013 | β |
| Mesenchymal stem cells and the lung. | Sinclair K et al. | β | 2013 | β |
| Methods for assessing effects of Wnt/Ξ²-catenin signaling in senescence of mesenchymal stem cells. | Wang HJ et al. | β | 2013 | β |
| MicroRNA-10A* and MicroRNA-21 modulate endothelial progenitor cell senescence via suppressing high-mobility group A2. | Zhu S et al. | β | 2013 | β |
| Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model. | Burd CE et al. | β | 2013 | β |
| mTOR is a key modulator of ageing and age-related disease. | Johnson SC et al. | β | 2013 | β |
| Nfatc1 orchestrates aging in hair follicle stem cells. | Keyes BE et al. | β | 2013 | β |
| Nucleus pulposus degeneration alters properties of resident progenitor cells. | Mizrahi O et al. | β | 2013 | β |
| PTEN controls Ξ²-cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a. | Zeng N et al. | β | 2013 | β |
| Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence. | Sadaie M et al. | β | 2013 | β |
| Regenerative medicine for the kidney: stem cell prospects & challenges. | Li Y et al. | β | 2013 | β |
| Role of sirtuins in stem cell differentiation. | Rodriguez RM et al. | β | 2013 | β |
| Senescence, ageing and death of the whole plant. | Thomas H | β | 2013 | β |
| Senescence regulation by the p53 protein family. | Qian Y et al. | β | 2013 | β |
| Skin stem cell hypotheses and long term clone survival--explored using agent-based modelling. | Li X et al. | β | 2013 | β |
| Stem cell function and maintenance - ends that matter: role of telomeres and telomerase. | Saeed H et al. | β | 2013 | β |
| Sublethal oxidative stress induces the premature senescence of human mesenchymal stem cells derived from endometrium. | Burova E et al. | β | 2013 | β |
| Telomerase is required for zebrafish lifespan. | Henriques CM et al. | β | 2013 | β |
| The decay of stem cell nourishment at the niche. | Font de Mora J et al. | β | 2013 | β |
| The hallmarks of aging. | LΓ³pez-OtΓn C et al. | β | 2013 | β |
| The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs). | Kucia M et al. | β | 2013 | β |
| The role of aging upon Ξ² cell turnover. | Kushner JA | β | 2013 | β |
| Transcriptomics of cortical gray matter thickness decline during normal aging. | Kochunov P et al. | β | 2013 | β |
| Tumor suppressors: enhancers or suppressors of regeneration? | Pomerantz JH et al. | β | 2013 | β |
| Uncovering the cellular and molecular changes in tendon stem/progenitor cells attributed to tendon aging and degeneration. | Kohler J et al. | β | 2013 | β |
| A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage. | Wang J et al. | β | 2012 | β |
| Age-related cognitive decline: can neural stem cells help us? | Artegiani B et al. | β | 2012 | β |
| Aging and dry eye disease. | Ding J et al. | β | 2012 | β |
| Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. | Rando TA et al. | β | 2012 | β |
| Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence. | Chen J et al. | β | 2012 | β |
| Dauer larva quiescence alters the circuitry of microRNA pathways regulating cell fate progression in C. elegans. | Karp X et al. | β | 2012 | β |
| Detectable clonal mosaicism from birth to old age and its relationship to cancer. | Laurie CC et al. | β | 2012 | β |
| Differentiation of human Wharton's jelly cells toward nucleus pulposus-like cells after coculture with nucleus pulposus cells in vitro. | Ruan D et al. | β | 2012 | β |
| Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effect. | Zanichelli F et al. | β | 2012 | β |
| Effect of ionizing radiation induced damage of endothelial progenitor cells in vascular regeneration. | Lee MO et al. | β | 2012 | β |
| Expression of p16(INK4a) as a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy. | Nelson JA et al. | β | 2012 | β |
| Genetic regulation of thymocyte progenitor aging. | Berent-Maoz B et al. | β | 2012 | β |
| Genotoxic exposure during juvenile growth of mammary gland depletes stem cell activity and inhibits Wnt signaling. | Klos KS et al. | β | 2012 | β |
| Heterozygote genotypes at rs2222823 and rs2811712 SNP loci are associated with cerebral small vessel disease in Han Chinese population. | Li W et al. | β | 2012 | β |
| Low concentrations of isothiocyanates protect mesenchymal stem cells from oxidative injuries, while high concentrations exacerbate DNA damage. | Zanichelli F et al. | β | 2012 | β |
| Macro lncRNAs: a new layer of cis-regulatory information in the mammalian genome. | Guenzl PM et al. | β | 2012 | β |
| Mechanisms of telomere loss and their consequences for chromosome instability. | Muraki K et al. | β | 2012 | β |
| Microarray analysis of ageing-related signatures and their expression in tumors based on a computational biology approach. | Wang X | β | 2012 | β |
| Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. | Lavasani M et al. | β | 2012 | β |
| Niche science: the aging stem cell. | Jasper H et al. | β | 2012 | β |
| Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage. | Kapuria S et al. | β | 2012 | β |
| Oncogenic challenges in stem cells and the link to cancer initiation. | Lee JS et al. | β | 2012 | β |
| Platelet-rich plasma-derived growth factors promote osteogenic differentiation of rat muscle satellite cells: in vitro and in vivo studies. | Huang S et al. | β | 2012 | β |
| Prenatal stress, telomere biology, and fetal programming of health and disease risk. | Entringer S et al. | β | 2012 | β |
| Progeroid syndromes: models for stem cell aging? | Bellantuono I et al. | β | 2012 | β |
| Regulation of skin aging and heart development by TAp63. | Paris M et al. | β | 2012 | β |
| Review: a meta-analysis of GWAS and age-associated diseases. | Jeck WR et al. | β | 2012 | β |
| Senescence: a new weapon for cancer therapy. | Acosta JC et al. | β | 2012 | β |
| Single-strand DNA breaks in human hair root cells exposed to mobile phone radiation. | Γam ST et al. | β | 2012 | β |
| Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice. | Ahlqvist KJ et al. | β | 2012 | β |
| Stem cells propagate their DNA by random segregation in the flatworm Macrostomum lignano. | Verdoodt F et al. | β | 2012 | β |
| Telomere loss, not average telomere length, confers radiosensitivity to TK6-irradiated cells. | Berardinelli F et al. | β | 2012 | β |
| Telomeres and mitochondria in the aging heart. | Moslehi J et al. | β | 2012 | β |
| Tracking chromatid segregation to identify human cardiac stem cells that regenerate extensively the infarcted myocardium. | Kajstura J et al. | β | 2012 | β |
| Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design. | Diaz-Cano SJ | β | 2012 | β |
| Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells. | Yahata T et al. | β | 2011 | β |
| A comparison of stem cells for therapeutic use. | Rodgerson DO et al. | β | 2011 | β |
| Advanced Donor Age Impairs Bone Marrow Cell Therapeutic Efficacy for Cardiac Disease. | Wang X et al. | β | 2011 | β |
| Ageing: Old cells under attack. | Peeper DS | β | 2011 | β |
| Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection? | Henry CJ et al. | β | 2011 | β |
| Aging genetics and aging. | RodrΓguez-Rodero S et al. | β | 2011 | β |
| ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS. | Pasmant E et al. | β | 2011 | β |
| A review and appraisal of the DNA damage theory of ageing. | Freitas AA et al. | β | 2011 | β |
| A stem cell niche dominance theorem. | Wolkenhauer O et al. | β | 2011 | β |
| At the stem of youth and health. | Beltrami AP et al. | β | 2011 | β |
| Biologic function and clinical potential of telomerase and associated proteins in cardiovascular tissue repair and regeneration. | Madonna R et al. | β | 2011 | β |
| Caloric restriction attenuates the age-associated increase of adipose-derived stem cells but further reduces their proliferative capacity. | Schmuck EG et al. | β | 2011 | β |
| Cell cycle regulation in hematopoietic stem cells. | Pietras EM et al. | β | 2011 | β |
| Characterization of the radioresponse of human apical papilla-derived cells. | Abe S et al. | β | 2011 | β |
| Child health, developmental plasticity, and epigenetic programming. | Hochberg Z et al. | β | 2011 | β |
| Computational analysis of expression of human embryonic stem cell-associated signatures in tumors. | Wang X | β | 2011 | β |
| Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation. | Oliver L et al. | β | 2011 | β |
| Effects of age and heart failure on human cardiac stem cell function. | Cesselli D et al. | β | 2011 | β |
| EGF signaling regulates the proliferation of intestinal stem cells in Drosophila. | Biteau B et al. | β | 2011 | β |
| Embryonic anti-aging niche. | Conboy IM et al. | β | 2011 | β |
| Emerging models and paradigms for stem cell ageing. | Jones DL et al. | β | 2011 | β |
| Epigenetic regulation of aging stem cells. | Pollina EA et al. | β | 2011 | β |
| Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence. | Cho J et al. | β | 2011 | β |
| Exploring biologically relevant pathways in frailty. | Ho YY et al. | β | 2011 | β |
| Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes. | Liu Y et al. | β | 2011 | β |
| Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease. | Khandanpour C et al. | β | 2011 | β |
| HGPS-derived iPSCs for the ages. | Misteli T | β | 2011 | β |
| HIV infection, inflammation, immunosenescence, and aging. | Deeks SG | β | 2011 | β |
| Identification and isolation from either adult human bone marrow or G-CSF-mobilized peripheral blood of CD34(+)/CD133(+)/CXCR4(+)/ Lin(-)CD45(-) cells, featuring morphological, molecular, and phenotypic characteristics of very small embryonic-like (VSEL) stem cells. | Sovalat H et al. | β | 2011 | β |
| Importance of serum source for the in vitro replicative senescence of human bone marrow derived mesenchymal stem cells. | Duggal S et al. | β | 2011 | β |
| Inhibition of p38 mitogen-activated protein kinase promotes ex vivo hematopoietic stem cell expansion. | Wang Y et al. | β | 2011 | β |
| Integrating physiological regulation with stem cell and tissue homeostasis. | Nakada D et al. | β | 2011 | β |
| Interface between normal and transformed epithelial cells: a road to a novel type of cancer prevention and treatment. | Fujita Y | β | 2011 | β |
| Lineage-specific pleiotropy in immune aging. | Eshraghi P et al. | β | 2011 | β |
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