Transcriptional regulation of cortical neuron migration by POU domain factors.
paper
Cited
Public
Unavailable
- Authors
- McEvilly, Robert J; de Diaz, Marcela Ortiz; Schonemann, Marcus D; Hooshmand, Farideh; Rosenfeld, Michael G
- Year
- 2002
- Journal
- Science (New York, N.Y.)
- PMID
- 11859196
- DOI
- 10.1126/science.1067132
The identification of pathways mediated by the kinase Cdk5 and the ligand reelin has provided a conceptual framework for exploring the molecular mechanisms underlying proper lamination of the developing mammalian cerebral cortex. In this report, we identify a component of the regulation of Cdk5-mediated cortical lamination by genetic analysis of the roles of the class III POU domain transcription factors, Brn-1 and Brn-2, expressed during the development of the forebrain and coexpressed in most layer II-V cortical neurons. Brn-1 and Brn-2 appear to critically control the initiation of radial migration, redundantly regulating the cell-autonomous expression of the p35 and p39 regulatory subunits of Cdk5 in migrating cortical neurons, with Brn-1(-/-)/Brn-2(-/-) mice exhibiting cortical inversion.
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