Cocaine-induced reduction of brain neuropeptide Y synthesis dependent on medial prefrontal cortex.
paper
Cited
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- Authors
- Wahlestedt, C; Karoum, F; Jaskiw, G; Wyatt, R J; Larhammar, D; Ekman, R; Reis, D J
- Year
- 1991
- Journal
- Proceedings of the National Academy of Sciences of the United States of America
- PMID
- 2006146
- DOI
- 10.1073/pnas.88.6.2078
- PMCID
- PMC51172
Repeated administration of cocaine elicits substantial, long-lasting, but reversible reductions in neuropeptide Y (NPY) and NPY mRNA in the rat cerebral cortex and nucleus accumbens. The NPY reduction appears to be mediated through a decrease in NPY biosynthesis, occurring transneuronally, perhaps in response to changes in synaptic dopamine associated with mesolimbic and mesocortical dopamine neurons. The medial prefrontal cortex appears necessary for maintenance of cocaine's action on this neuronal network since excitotoxic lesions of this area prevented (lesion before cocaine) and reversed (lesion after cocaine) the reductions in NPY elicited by the cocaine. NPY may be a sensitive marker for chronic cocaine use. Its decrease may relate to the anxiety and depression associated with cocaine withdrawal in humans.
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| Title | Year | PMID |
|---|---|---|
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | 2008 | 18828811 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Neuropeptide Y and Pain: Insights from Brain Research. | Nelson TS et al. | — | 2024 | → |
| Cross talk about the role of Neuropeptide Y in CNS disorders and diseases. | Bale R et al. | — | 2023 | → |
| The Role of Neuropeptide Y in the Nucleus Accumbens. | Tanaka M et al. | — | 2021 | → |
| Turning the 'Tides on Neuropsychiatric Diseases: The Role of Peptides in the Prefrontal Cortex. | Brockway DF et al. | — | 2020 | → |
| ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine. | Berezniuk I et al. | — | 2017 | → |
| The impact of cocaine on adult hippocampal neurogenesis: Potential neurobiological mechanisms and contributions to maladaptive cognition in cocaine addiction disorder. | Castilla-Ortega E et al. | — | 2017 | → |
| The Role of Neuropeptide Y (NPY) in Alcohol and Drug Abuse Disorders. | Robinson SL et al. | — | 2017 | → |
| Effects of drugs of abuse on the central neuropeptide Y system. | Gonçalves J et al. | — | 2016 | → |
| Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight. | Qiu B et al. | — | 2016 | → |
| Connecting the pathology of posttraumatic stress and substance use disorders: monoamines and neuropeptides. | Enman NM et al. | — | 2014 | → |
| Neuropeptide Y (NPY) in the extended amygdala is recruited during the transition to alcohol dependence. | Gilpin NW | — | 2012 | → |
| Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice. | Sørensen G et al. | — | 2012 | → |
| Neural substrates of psychostimulant withdrawal-induced anhedonia. | D'Souza MS et al. | — | 2010 | → |
| Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. | Okahisa Y et al. | — | 2009 | → |
| Neuropeptide Y infusion into the shell region of the rat nucleus accumbens increases extracellular levels of dopamine. | Sørensen G et al. | — | 2009 | → |
| Behavioral neuroendocrinology and treatment of anorexia nervosa. | Södersten P et al. | — | 2008 | → |
| Correlating human and animal studies of cocaine abuse and gene expression. | Lull ME et al. | — | 2008 | → |
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | Wetherill L et al. | — | 2008 | → |
| Persistent alterations in mesolimbic gene expression with abstinence from cocaine self-administration. | Freeman WM et al. | — | 2008 | → |
| Increased expression of protein kinase A inhibitor alpha (PKI-alpha) and decreased PKA-regulated genes in chronic intermittent alcohol exposure. | Repunte-Canonigo V et al. | — | 2007 | → |
| Mechanism of dopamine mediated inhibition of neuropeptide Y release from pheochromocytoma cells (PC12 cells). | Cao G et al. | — | 2007 | → |
| Neuropeptide Y (NPY) in alcohol intake and dependence. | Thorsell A | — | 2007 | → |
| Effects of maternal separation on neuropeptide Y and calcitonin gene-related peptide in "depressed" Flinders Sensitive Line rats: a study of gene-environment interactions. | Wörtwein G et al. | — | 2006 | → |
| Quantitative peptidomics in mice: effect of cocaine treatment. | Che FY et al. | — | 2006 | → |
| Psychostimulant withdrawal as an inducing condition in animal models of depression. | Barr AM et al. | — | 2005 | → |
| The "Yoking" of glutamatergic brain mechanisms involved in controlling brain neuronal excitability and psychosis to brain mechanisms involved in appetite regulation: a new hypothesis on the origin of psychosis. | Rosse RB et al. | — | 2004 | → |
| Effects of haloperidol and clozapine on neuropeptide Y-like immunoreactivity in the nucleus accumbens and striatum of rats pretreated with psychostimulants. | Obuchowicz E et al. | — | 2003 | → |
| Nicotine regulates 5-HT(1A) receptor gene expression in the cerebral cortex and dorsal hippocampus. | Kenny PJ et al. | — | 2001 | → |
| Basal expression of c-Fos and Zif268 in the rat basal ganglia: immunohistochemical characterization of striatal Zif268-positive neurons. | Ishida Y et al. | — | 2000 | → |
| Effects of typical and atypical antipsychotics on neuropeptide Y in rat brain tissue and microdialysates from ventral striatum. | Gruber SH et al. | — | 2000 | → |
| Neuropeptide Y in brains of the Flinders Sensitive Line rat, a model of depression. Effects of electroconvulsive stimuli and d-amphetamine on peptide concentrations and locomotion. | Jiménez Vasquez PA et al. | — | 2000 | → |
| Neuropeptide Y in male and female brains of Flinders Sensitive Line, a rat model of depression. Effects of electroconvulsive stimuli. | Jiménez-Vasquez PA et al. | — | 2000 | → |
| Drugs of abuse and brain gene expression. | Torres G et al. | — | 1999 | → |
| The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience. | O'Donovan KJ et al. | — | 1999 | → |
| Alterations in neuropeptide Y and Y1 receptor mRNA expression in brains from an animal model of depression: region specific adaptation after fluoxetine treatment. | Caberlotto L et al. | — | 1998 | → |
| Neuropeptide Y attenuates naloxone-precipitated morphine withdrawal via Y5-like receptors. | Woldbye DP et al. | — | 1998 | → |
| Effects of electroconvulsive stimuli and MK-801 on neuropeptide Y, neurokinin A, and calcitonin gene-related peptide in rat brain. | Mathé AA et al. | — | 1997 | → |
| Laminar distribution of neuropeptide Y-immunoreactive neurons in human prefrontal cortex during development. | Delalle I et al. | — | 1997 | → |
| Altered neuronal distribution of parvalbumin in anterior cingulate cortex of rabbits exposed in utero to cocaine. | Wang XH et al. | — | 1996 | → |
| Regulation of neuropeptide expression in the brain by neurotrophins. Potential role in vivo. | Carnahan J et al. | — | 1995 | → |
| Rapid increases in peptide processing enzyme expression in hippocampal neurons. | Bhat RV et al. | — | 1993 | → |
| Conditioned sensitization to the psychomotor stimulant cocaine. | Post RM et al. | — | 1992 | → |