Gender-specific effects of the catechol-O-methyltransferase Val108/158Met polymorphism on cognitive function in children.
paper
Cited
Public
Unavailable
- Authors
- Barnett, Jennifer H; Heron, Jon; Ring, Susan M; Golding, Jean; Goldman, David; Xu, Ke; Jones, Peter B
- Year
- 2007
- Journal
- The American journal of psychiatry
- PMID
- 17202556
- DOI
- 10.1176/ajp.2007.164.1.142
OBJECTIVE: The study aimed to determine the cognitive effect of the Val108/158Met polymorphism in the catechol-O-methyltransferase (COMT) gene in children before and during puberty. This polymorphism affects cognitive function in healthy adults and may contribute to risk for schizophrenia. METHOD: COMT genotype was determined for 8,707 children from the Avon Longitudinal Study of Parents and Children (ALSPAC), a geographically defined general population cohort of children born between April 1, 1991, and Dec. 31, 1992, in the southwest of England. Fourteen measures of cognitive function--including working memory, verbal and motor inhibition, attentional control, and IQ--were assessed at ages 8 and 10 years. Any pubertal development at age 9 years was reported by parents. Effects of COMT genotype on cognition and interactions with gender and puberty were assessed using general linear models. RESULTS: In boys, genotype significantly affected executive function and explained up to 10 points normal variation in verbal IQ. The effects on IQ were significantly greater in pubertal than in prepubertal boys. In girls, there were no significant effects of genotype on cognition. CONCLUSIONS: This common polymorphism may be one of the genes of small effect that contribute to normal variation in IQ. The gender-specific nature of the effect and its possible interaction with puberty may be relevant to both normal cognitive and brain development and to abnormal development in disorders such as schizophrenia.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genetic correlates of the development of theta event related oscillations in adolescents and young adults. | 2017 | 27847216 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Exploring gender differences in vocational education and training through the lens of neuroscience. | Zhou J et al. | — | 2025 | → |
| The differential impact of increasing and decreasing maternal work-family conflict on children's executive function difficulties in South Korea. | Son H et al. | — | 2025 | → |
| Catechol-O-methyltransferase gene (COMT) is associated with neurocognitive functioning in patients with sickle cell disease. | Heitzer AM et al. | — | 2024 | → |
| EPELI: a novel virtual reality task for the assessment of goal-directed behavior in real-life contexts. | Seesjärvi E et al. | — | 2023 | → |
| Gender divergent effect of COMT gene rs4680 polymorphism on the association between executive dysfunction and psychotic-like experiences. | Gong J et al. | — | 2023 | → |
| Genetic bases of language control in bilinguals: Evidence from an EEG study. | Liu D et al. | — | 2023 | → |
| Task-related functional neuroimaging contribution to sex/gender differences in cognition and emotion during development. | Taddei M et al. | — | 2023 | → |
| Evidence for anti-inflammatory effects and modulation of neurotransmitter metabolism by Salvia officinalis L. | Margetts G et al. | — | 2022 | → |
| Parenting Styles Predict Future-Oriented Cognition in Children: A Cross-Sectional Study. | Sadeghi S et al. | — | 2022 | → |
| Peer victimization (bullying) on mental health, behavioral problems, cognition, and academic performance in preadolescent children in the ABCD Study. | Menken MS et al. | — | 2022 | → |
| Schoolchildren's autobiographical memory: COMT gene Val<sup>158</sup>Met polymorphism effects on emotional content and quality of first memories. | Tõugu P et al. | — | 2022 | → |
| The inconsistent mediating effect of catechol <i>O</i> methyl transferase Val<sup>158</sup>Met polymorphism on the sex difference of cognitive impairment in schizophrenia patients. | Xu H et al. | — | 2022 | → |
| Executive function of the brain and its influences on understanding of physics concept. | Abdullah MNS et al. | — | 2021 | → |
| Associations between stuttering, comorbid conditions and executive function in children: a population-based study. | Choo AL et al. | — | 2020 | → |
| Female-specific effects of the catechol-O-methyl transferase Val<sup>158</sup>Met gene polymorphism on working memory-related brain function. | Fan J et al. | — | 2020 | → |
| Dopamine and Working Memory: Genetic Variation, Stress and Implications for Mental Health. | Klaus K et al. | — | 2019 | → |
| Heterosis in COMT Val158Met Polymorphism Contributes to Sex-Differences in Children's Math Anxiety. | Júlio-Costa A et al. | — | 2019 | → |
| Let's call the whole thing off: evaluating gender and sex differences in executive function. | Grissom NM et al. | — | 2019 | → |
| No association of <i>COMT</i> with insight problem solving in Chinese college students. | Yang X et al. | — | 2019 | → |
| Explicit Performance in Girls and Implicit Processing in Boys: A Simultaneous fNIRS-ERP Study on Second Language Syntactic Learning in Young Adolescents. | Sugiura L et al. | — | 2018 | → |
| Genetic influences on creativity: an exploration of convergent and divergent thinking. | Han W et al. | — | 2018 | → |
| Influence of Concussion History and Genetics on Event-Related Potentials in Athletes: Potential Use in Concussion Management. | Guth T et al. | — | 2018 | → |
| Interaction of childhood urbanicity and variation in dopamine genes alters adult prefrontal function as measured by functional magnetic resonance imaging (fMRI). | Reed JL et al. | — | 2018 | → |
| Adolescence is the starting point of sex-dichotomous COMT genetic effects. | Sannino S et al. | — | 2017 | → |
| Age-Dependent Effects of Catechol-O-Methyltransferase (COMT) Gene Val158Met Polymorphism on Language Function in Developing Children. | Sugiura L et al. | — | 2017 | → |
| Association between COMT genotype and the control of memory guided saccades: Individual differences in healthy adults reveal a detrimental role of dopamine. | Billino J et al. | — | 2017 | → |
| Attentional Control in Adolescent Mice Assessed with a Modified Five Choice Serial Reaction Time Task. | Ciampoli M et al. | — | 2017 | → |
| Genetic correlates of the development of theta event related oscillations in adolescents and young adults. | Chorlian DB et al. | — | 2017 | → |
| Hypothesizing Music Intervention Enhances Brain Functional Connectivity Involving Dopaminergic Recruitment: Common Neuro-correlates to Abusable Drugs. | Blum K et al. | — | 2017 | → |
| Longitudinal study of premorbid adjustment in 22q11.2 deletion (velocardiofacial) syndrome and association with psychosis. | Radoeva PD et al. | — | 2017 | → |
| A Dopamine Pathway Gene Risk Score for Cognitive Recovery Following Traumatic Brain Injury: Methodological Considerations, Preliminary Findings, and Interactions With Sex. | Myrga JM et al. | — | 2016 | → |
| Catechol-O-methyltransferase val(158)met Polymorphism Interacts with Sex to Affect Face Recognition Ability. | Lamb YN et al. | — | 2016 | → |
| Identifying mechanisms that underlie links between COMT genotype and aggression in male adolescents with ADHD. | van Goozen SH et al. | — | 2016 | → |
| Interactive effects of age and multi-gene profile on motor learning and sensorimotor adaptation. | Noohi F et al. | — | 2016 | → |
| <i>COMT</i> and <i>DAT1</i> genes are associated with hyperactivity and inattention traits in the 1993 Pelotas Birth Cohort: evidence of sex-specific combined effect. | Akutagava-Martins GC et al. | — | 2016 | → |
| Meta-analysis of the COMT Val158Met polymorphism in major depressive disorder: the role of gender. | Klein M et al. | — | 2016 | → |
| Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults. | Meyer BM et al. | — | 2016 | → |
| Reduced brain activation during inhibitory control in children with <i>COMT</i> Val/Val genotype. | Cope LM et al. | — | 2016 | → |
| The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder. | Jin J et al. | — | 2016 | → |
| The Role of Dopamine in Anticipatory Pursuit Eye Movements: Insights from Genetic Polymorphisms in Healthy Adults. | Billino J et al. | — | 2016 | → |
| A Genetic Variant (COMT) Coding Dopaminergic Activity Predicts Personality Traits in Healthy Elderly. | Kotyuk E et al. | — | 2015 | → |
| COMT polymorphism modulates the resting-state EEG alpha oscillatory response to acute nicotine in male non-smokers. | Bowers H et al. | — | 2015 | → |
| [Current state and potential of pharmacogenetic studies in the treatment of depression]. | Ivanets NN et al. | — | 2015 | → |
| Dopamine and cognitive control: sex-by-genotype interactions influence the capacity to switch attention. | Gurvich C et al. | — | 2015 | → |
| Genetic influences on insight problem solving: the role of catechol-O-methyltransferase (COMT) gene polymorphisms. | Jiang W et al. | — | 2015 | → |
| Inhibition of catechol-O-methyl transferase (COMT) by tolcapone restores reductions in microtubule-associated protein 2 (MAP2) and synaptophysin (SYP) following exposure of neuronal cells to neurotropic HIV. | Lee TT et al. | — | 2015 | → |
| Association of COMT and PRODH gene variants with intelligence quotient (IQ) and executive functions in 22q11.2DS subjects. | Carmel M et al. | — | 2014 | → |
| Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene. | Luo XJ et al. | — | 2014 | → |
| Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain. | Smith SB et al. | — | 2014 | → |
| Exploring the indirect effects of catechol-O-methyltransferase (COMT) genotype on psychotic experiences through cognitive function and anxiety disorders in a large birth cohort of children. | Niarchou M et al. | — | 2014 | → |
| Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children. | Woods JS et al. | — | 2014 | → |
| Perceived stress during pregnancy and the catechol-O-methyltransferase (COMT) rs165599 polymorphism impacts on childhood IQ. | Lamb YN et al. | — | 2014 | → |
| Preliminary investigation of the influence of dopamine regulating genes on social working memory. | Dumontheil I et al. | — | 2014 | → |
| Sex differences in COMT polymorphism effects on prefrontal inhibitory control in adolescence. | White TP et al. | — | 2014 | → |
| Catechol-O-methyltransferase Val158Met polymorphism modulates gray matter volume and functional connectivity of the default mode network. | Tian T et al. | — | 2013 | → |
| Dogslife: a web-based longitudinal study of Labrador Retriever health in the UK. | Clements DN et al. | — | 2013 | → |
| Gender effects of the COMT Val 158 Met genotype on verbal fluency in healthy adults. | Soeiro-De-Souza MG et al. | — | 2013 | → |
| Lack of association between COMT and working memory in a population-based cohort of healthy young adults. | Wardle MC et al. | — | 2013 | → |
| Neuropsychological correlates of transcription factor AP-2Beta, and its interaction with COMT and MAOA in healthy females. | Schabram I et al. | — | 2013 | → |
| Pathways from cannabis to psychosis: a review of the evidence. | Burns JK | — | 2013 | → |
| Sexually dimorphic effects of catechol-O-methyltransferase (COMT) inhibition on dopamine metabolism in multiple brain regions. | Laatikainen LM et al. | — | 2013 | → |
| The association between sleep spindles and IQ in healthy school-age children. | Gruber R et al. | — | 2013 | → |
| The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence. | Gaysina D et al. | — | 2013 | → |
| No association of COMT (Val158Met) genotype with brain structure differences between men and women. | Barnes A et al. | — | 2012 | → |
| Telomere length and early severe social deprivation: linking early adversity and cellular aging. | Drury SS et al. | — | 2012 | → |
| Association of the functional polymorphism in the catechol-O-methyltransferase gene with schizophrenia in the three ethnic groups of the Malaysian population. | Wan CL et al. | — | 2011 | → |
| Cognitive effects of genetic variation in monoamine neurotransmitter systems: a population-based study of COMT, MAOA, and 5HTTLPR. | Barnett JH et al. | — | 2011 | → |
| COMT gene polymorphism and corpus callosum morphometry in preterm born adults. | Dutt A et al. | — | 2011 | → |
| Importance of the COMT gene for sex differences in brain function and predisposition to psychiatric disorders. | Tunbridge EM et al. | — | 2011 | → |
| Influence of the COMT genotype on working memory and brain activity changes during development. | Dumontheil I et al. | — | 2011 | → |
| IQ, educational attainment, memory and plasma lipids: associations with apolipoprotein E genotype in 5995 children. | Taylor AE et al. | — | 2011 | → |
| Catechol O-methyltransferase variants and cognitive performance in schizophrenia and bipolar disorder versus controls. | Wirgenes KV et al. | — | 2010 | → |
| Gene-gene interaction between COMT and MAOA potentially predicts the intelligence of attention-deficit hyperactivity disorder boys in China. | Qian QJ et al. | — | 2010 | → |
| Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats. | Meyers B et al. | — | 2010 | → |
| Neurobehavioral evidence for changes in dopamine system activity during adolescence. | Wahlstrom D et al. | — | 2010 | → |
| The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met polymorphism on emotion regulation in velo-cardio-facial syndrome (22q11.2 deletion syndrome): An fMRI study. | Coman IL et al. | — | 2010 | → |
| Association of catechol-O-methyltransferase (COMT) polymorphism and academic achievement in a Chinese cohort. | Yeh TK et al. | — | 2009 | → |
| Attention Deficit Hyperactivity Disorder comorbid oppositional defiant disorder and its predominately inattentive type: evidence for an association with COMT but not MAOA in a Chinese sample. | Qian QJ et al. | — | 2009 | → |
| Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children. | Barnett JH et al. | — | 2009 | → |
| Heritability of regional and global brain structure at the onset of puberty: a magnetic resonance imaging study in 9-year-old twin pairs. | Peper JS et al. | — | 2009 | → |
| Musical aptitude is associated with AVPR1A-haplotypes. | Ukkola LT et al. | — | 2009 | → |
| No association between Cholinergic Muscarinic Receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples. | Lind PA et al. | — | 2009 | → |
| Sexually dimorphic effect of catechol-O-methyltransferase val158met polymorphism on clinical response to fluoxetine in major depressive patients. | Tsai SJ et al. | — | 2009 | → |
| Association between variation in the vesicular monoamine transporter 1 gene on chromosome 8p and anxiety-related personality traits. | Lohoff FW et al. | — | 2008 | → |
| Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders. | Harrison PJ et al. | — | 2008 | → |
| DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents. | Bombin I et al. | — | 2008 | → |
| Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. | van Os J et al. | — | 2008 | → |
| Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism. | Barnett JH et al. | — | 2008 | → |
| A Trio of Concerns. | Kagan J | — | 2007 | → |
| COMT genotype and cognitive ability: a longitudinal aging study. | Starr JM et al. | — | 2007 | → |
| Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls. | Barnett JH et al. | — | 2007 | → |
| Exploring interactive effects of genes and environments in etiology of individual differences in reading comprehension. | Grigorenko EL et al. | — | 2007 | → |
| Gender differences in 542 Chinese inpatients with schizophrenia. | Tang YL et al. | — | 2007 | → |
| Intelligence and the developing human brain. | Shaw P | — | 2007 | → |
| Is COMT a susceptibility gene for schizophrenia? | Williams HJ et al. | — | 2007 | → |
| Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase. | Foroud T et al. | — | 2007 | → |
| Relationship of catechol-O-methyltransferase to schizophrenia and its correlates: evidence for associations and complex interactions. | Lewandowski KE | — | 2007 | → |
| Schizophrenia susceptibility genes and neurodevelopment. | Harrison PJ | — | 2007 | → |
| The effects of tobacco smoke and nicotine on cognition and the brain. | Swan GE et al. | — | 2007 | → |