Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization.
paper
Cited
Public
Unavailable
- Authors
- Heidmann, D E; Metcalf, M A; Kohen, R; Hamblin, M W
- Year
- 1997
- Journal
- Journal of neurochemistry
- PMID
- 9084407
- DOI
- 10.1046/j.1471-4159.1997.68041372.x
The serotonin (5-HT) 5-HT7 receptor subtype is thought to mediate a number of physiological effects in mammalian brain and periphery. Previous studies suggested that alternative splicing might contribute to 5-HT7 receptor diversity as well. We now report that alternative splicing in human and rat tissues produces four 5-HT7 receptor isoforms that differ in their predicted C-terminal intracellular tails. Human and rat partial 5-HT7 cDNAs and intronic sequences were identified and compared. In rat tissues, three 5-HT7 isoforms, here called 5-HT7(a), 5-HT7(b), and 5-HT7(c), are found. Rat 5-HT7(a) [448-amino acid (aa)] and 5-HT7(b) (435-aa) forms arise from alternative splice donor sites. A third new isoform found in rat, 5-HT7(c) (470-aa), results from a retained exon cassette. Three 5-HT7 mRNA isoforms were also identified in human tissues, where only one isoform was previously described. Two human isoforms represent 5-HT7(a) and 5-HT7(b) forms (445- and 432-aa), but the third form does not correspond to 5-HT7(c). Instead, it constitutes a distinct isoform, 5-HT7(d) (479-aa), resulting from retention of a separate exon cassette. 5-HT7(d) transcripts are not present in rat because the 5-HT7(d)-specifying exon is absent from the rat 5-HT7 gene. A frame-shifting homologue of the rat 5-HT7(c)-Specifying exon is present in the human gene but is not used in the human tissues examined. Tissue-specific splicing differences are present in human between brain and spleen. These studies suggest that alternative splicing may contribute to diversity of 5-HT7 receptor action and that the human and rat repertoires of 5-HT7 splice variants are substantially different.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence. | 2011 | 21184583 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| BiMA-DTI: a bidirectional Mamba-Attention hybrid framework for enhanced drug-target interaction prediction. | Shui Y et al. | β | 2025 | β |
| Serotonergic Regulation in Alzheimer's Disease. | Dolgacheva LP et al. | β | 2025 | β |
| Serotonin Receptors in Myocardial Infarction: Friend or Foe? | Bahr FS et al. | β | 2024 | β |
| Serotonergic 5-HT<sub>7</sub> Receptors as Modulators of the Nociceptive System. | Bardoni R | β | 2023 | β |
| Therapeutic Potential and Limitation of Serotonin Type 7 Receptor Modulation. | Fukuyama K et al. | β | 2023 | β |
| Benzoxazolone-arylpiperazinyl scaffold-based PET ligand for 5-HT<sub>7</sub> : Synthesis and biological evaluation. | Kumari N et al. | β | 2022 | β |
| Central nervous system effects of 5-HT<sub>7</sub> receptors: a potential target for neurodegenerative diseases. | Quintero-Villegas A et al. | β | 2022 | β |
| Identification and Pharmacological Characterization of Two Serotonin Type 7 Receptor Isoforms from <i>Mythimna separata</i>. | Chen W et al. | β | 2022 | β |
| Serotonin Receptors as Therapeutic Targets for Autism Spectrum Disorder Treatment. | Lee A et al. | β | 2022 | β |
| 5-HT Receptors and Temperature Homeostasis. | Voronova IP | β | 2021 | β |
| Current Limitations and Candidate Potential of 5-HT7 Receptor Antagonism in Psychiatric Pharmacotherapy. | Okubo R et al. | β | 2021 | β |
| International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function. | Barnes NM et al. | β | 2021 | β |
| Multiple facets of serotonergic modulation. | Beyeler A et al. | β | 2021 | β |
| Serotonin and beyond-a tribute to Manfred GΓΆthert (1939-2019). | BΓΆnisch H et al. | β | 2021 | β |
| 5-HT7 Receptor Inhibition Transiently Improves Respiratory Function Following Daily Acute Intermittent Hypercapnic-Hypoxia in Rats With Chronic Midcervical Spinal Cord Contusion. | Wu MJ et al. | β | 2020 | β |
| 5-HT7 receptorsare over-expressed in patients with nasal polyps. | Yayla M et al. | β | 2020 | β |
| Mitochondrial Membranes of Human SH-SY5Y Neuroblastoma Cells Express Serotonin 5-HT<sub>7</sub> Receptor. | Tempio A et al. | β | 2020 | β |
| Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease. | Crispino M et al. | β | 2020 | β |
| Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT<sub>7A</sub>R ligands. | Karki A et al. | β | 2020 | β |
| The role of 5-HT7 receptors on isoproterenol-induced myocardial infarction in rats with high-fat diet exacerbated coronary endothelial dysfunction. | Cinar I et al. | β | 2020 | β |
| Towards selective CNS PET imaging of the 5-HT<sub>7</sub> receptor system: Past, present and future. | L'Estrade ET et al. | β | 2020 | β |
| [1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HT<sub>7</sub> receptor. | Romeo G et al. | β | 2019 | β |
| MiRNA-29a modulates visceral hyperalgesia in irritable bowel syndrome by targeting HTR7. | Zhu H et al. | β | 2019 | β |
| Stimulating DDX3 expression by serotonin 5-HT receptor 7 through phosphorylation of p53 via the AC-PKA-ERK signaling pathway. | Kang LJ et al. | β | 2019 | β |
| Structure-activity relationships of serotonin 5-HT<sub>7</sub> receptors ligands: A review. | Thirumaran SL et al. | β | 2019 | β |
| Serotonin Receptor Binding Characteristics of Geissoschizine Methyl Ether, an Indole Alkaloid in Uncaria Hook. | Ikarashi Y et al. | β | 2018 | β |
| Serotonin receptors in depression and anxiety: Insights from animal studies. | Ε»mudzka E et al. | β | 2018 | β |
| How serotonin receptors regulate morphogenic signalling in neurons. | Wirth A et al. | β | 2017 | β |
| Serotonergic modulation of the activity of mesencephalic dopaminergic systems: Therapeutic implications. | De DeurwaerdΓ¨re P et al. | β | 2017 | β |
| New advances in the treatment of generalized anxiety disorder: the multimodal antidepressant vortioxetine. | Orsolini L et al. | β | 2016 | β |
| Serotonin disrupts esophageal mucosal integrity: an investigation using a stratified squamous epithelial model. | Wu L et al. | β | 2016 | β |
| Whole genome sequencing of a dizygotic twin suggests a role for the serotonin receptor HTR7 in autism spectrum disorder. | Helsmoortel C et al. | β | 2016 | β |
| Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1. | Manfra O et al. | β | 2015 | β |
| The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors. | Andressen KW et al. | β | 2015 | β |
| 5-HT7 receptors and tryptophan hydroxylase in lymphocytes of rats: mitogen activation, physical restraint or treatment with reserpine. | Urbina M et al. | β | 2014 | β |
| Cellular mechanisms of the 5-HT7 receptor-mediated signaling. | Guseva D et al. | β | 2014 | β |
| Interplay between serotonin 5-HT1A and 5-HT7 receptors in depressive disorders. | Naumenko VS et al. | β | 2014 | β |
| Modulatory effects following subchronic stimulation of brain 5-HT7-R system in mice and rats. | Romano E et al. | β | 2014 | β |
| Serotonin (5-HT) regulates neurite outgrowth through 5-HT1A and 5-HT7 receptors in cultured hippocampal neurons. | Rojas PS et al. | β | 2014 | β |
| Structure-activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT(7) and 5-HT(1A) receptor ligands. | Salerno L et al. | β | 2014 | β |
| The 5-HT7 receptor as a potential target for treating drug and alcohol abuse. | Hauser SR et al. | β | 2014 | β |
| Effects of geissoschizine methyl ether, an indole alkaloid in Uncaria hook, a constituent of yokukansan, on human recombinant serotonin 7 receptor. | Ueki T et al. | β | 2013 | β |
| Inflammation and peripheral 5-HT7 receptors: the role of 5-HT7 receptors in carrageenan induced inflammation in rats. | Albayrak A et al. | β | 2013 | β |
| Multiple roles of serotonin in pain control mechanisms--implications of 5-HTβ and other 5-HT receptor types. | Viguier F et al. | β | 2013 | β |
| Palmitoylation of serotonin receptors. | Gorinski N et al. | β | 2013 | β |
| Peripheral 5-HT7 receptors as a new target for prevention of lung injury and mortality in septic rats. | Cadirci E et al. | β | 2013 | β |
| The serotonin 5-HT7 receptors: two decades of research. | Gellynck E et al. | β | 2013 | β |
| RhoBTB3 interacts with the 5-HT7a receptor and inhibits its proteasomal degradation. | Matthys A et al. | β | 2012 | β |
| Serotonin (5-HT7) receptor-stimulated activation of cAMP-PKA pathway in bovine corneal epithelial and endothelial cells. | Grueb M et al. | β | 2012 | β |
| Antagonist interaction with the human 5-HT(7) receptor mediates the rapid and potent inhibition of non-G-protein-stimulated adenylate cyclase activity: a novel GPCR effect. | Klein MT et al. | β | 2011 | β |
| Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence. | Zlojutro M et al. | β | 2011 | β |
| Presynaptic control of serotonin on striatal dopamine function. | Navailles S et al. | β | 2011 | β |
| Role of the 5-HT7 receptor in the central nervous system: from current status to future perspectives. | Matthys A et al. | β | 2011 | β |
| Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders. | Leopoldo M et al. | β | 2011 | β |
| Brain serotonin system in the coordination of food intake and body weight. | Lam DD et al. | β | 2010 | β |
| Differences in the C-terminus contribute to variations in trafficking between rat and human 5-HT(2A) receptor isoforms: identification of a primate-specific tripeptide ASK motif that confers GRK-2 and beta arrestin-2 interactions. | Bhattacharya A et al. | β | 2010 | β |
| Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo. | Abbas AI et al. | β | 2009 | β |
| Constitutive Gs-mediated, but not G12-mediated, activity of the 5-hydroxytryptamine 5-HT7(a) receptor is modulated by the palmitoylation of its C-terminal domain. | Kvachnina E et al. | β | 2009 | β |
| Distribution of serotonin receptors and interacting proteins in the human sigmoid colon. | Chetty N et al. | β | 2009 | β |
| 5-HT(7) receptors in the modulation of cognitive processes. | Cifariello A et al. | β | 2008 | β |
| Cloning, genomic organization and functionality of 5-HT(7) receptor splice variants from mouse brain. | Gellynck E et al. | β | 2008 | β |
| Molecular biology of 5-HT receptors. | Hannon J et al. | β | 2008 | β |
| Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders. | Heal DJ et al. | β | 2008 | β |
| Caveolin-1 affects serotonin binding and cell surface levels of human 5-HT7(a) receptors. | SjΓΆgren B et al. | β | 2007 | β |
| Human 5-HT(4) and 5-HT(7) receptor splice variants: are they important? | Coupar IM et al. | β | 2007 | β |
| Mammary gland homeostasis employs serotonergic regulation of epithelial tight junctions. | Stull MA et al. | β | 2007 | β |
| Novel interaction between the human 5-HT7 receptor isoforms and PLAC-24/eIF3k. | De Martelaere K et al. | β | 2007 | β |
| Structure of the human 5-HT7 receptor gene and characterization of its promoter region. | Laenen K et al. | β | 2007 | β |
| 5-hydroxytryptamine receptors in the human cardiovascular system. | Kaumann AJ et al. | β | 2006 | β |
| Activation of adenylyl cyclase by endogenous G(s)-coupled receptors in human embryonic kidney 293 cells is attenuated by 5-HT(7) receptor expression. | Andressen KW et al. | β | 2006 | β |
| Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors. | SjΓΆgren B et al. | β | 2006 | β |
| Expression of mRNA for multiple serotonin (5-HT) receptor types/subtypes by the peripheral blood mononuclear cells of rhesus macaques. | Yang GB et al. | β | 2006 | β |
| Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation. | Bockaert J et al. | β | 2006 | β |
| Differential agonist-mediated internalization of the human 5-hydroxytryptamine 7 receptor isoforms. | Guthrie CR et al. | β | 2005 | β |
| Endogenous expression and protein kinase A-dependent phosphorylation of the guanine nucleotide exchange factor Ras-GRF1 in human embryonic kidney 293 cells. | Norum JH et al. | β | 2005 | β |
| Glycogen metabolism in rat ependymal primary cultures: regulation by serotonin. | Verleysdonk S et al. | β | 2005 | β |
| Intracellular cAMP and calcium signaling by serotonin in mouse cumulus-oocyte complexes. | Amireault P et al. | β | 2005 | β |
| "In vitro" postnatal expression of 5-HT7 receptors in the rat hypothalamus: an immunohistochemical analysis. | Russo A et al. | β | 2005 | β |
| Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells. | MahΓ© C et al. | β | 2005 | β |
| Slow excitatory post-synaptic potentials in myenteric AH neurons of the guinea-pig ileum are reduced by the 5-hydroxytryptamine7 receptor antagonist SB 269970. | Monro RL et al. | β | 2005 | β |
| 5-HT7 receptor efficacy distribution throughout the canine stomach. | Janssen P et al. | β | 2004 | β |
| 8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents. | Hedlund PB et al. | β | 2004 | β |
| Autoradiographic distribution of 5-HT7 receptors in the human brain using [3H]mesulergine: comparison to other mammalian species. | MartΓn-Cora FJ et al. | β | 2004 | β |
| Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors. | MahΓ© C et al. | β | 2004 | β |
| Functional 5-HT receptors in human occipital artery. | Verheggen R et al. | β | 2004 | β |
| Functional expression of the serotonin 5-HT7 receptor in human glioblastoma cell lines. | MahΓ© C et al. | β | 2004 | β |
| Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants. | Chen J et al. | β | 2004 | β |
| Influences of gender and region on responses to 5-HT in the rat small intestine. | Liu H et al. | β | 2004 | β |
| Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). | Glennon RA | β | 2003 | β |
| No hypothermic response to serotonin in 5-HT7 receptor knockout mice. | Hedlund PB et al. | β | 2003 | β |
| Potential clozapine target sites on peripheral hematopoietic cells and stromal cells of the bone marrow. | Pereira A et al. | β | 2003 | β |
| Ras-dependent ERK activation by the human G(s)-coupled serotonin receptors 5-HT4(b) and 5-HT7(a). | Norum JH et al. | β | 2003 | β |
| Unaltered agonist potency upon inducible 5-HT7(a) but not 5-HT4(b) receptor expression indicates agonist-independent association of 5-HT7(a) receptor and Gs. | Bruheim S et al. | β | 2003 | β |
| [3H]-SB-269970 radiolabels 5-HT7 receptors in rodent, pig and primate brain tissues. | Thomas DR et al. | β | 2002 | β |
| Activation of 5-HT(7) receptor in rat glomerulosa cells is associated with an increase in adenylyl cyclase activity and calcium influx through T-type calcium channels. | Lenglet S et al. | β | 2002 | β |
| An RT-PCR study of 5-HT(6) and 5-HT(7) receptor mRNAs in the hippocampal formation and prefrontal cortex in schizophrenia. | East SZ et al. | β | 2002 | β |
| Descending control of pain. | Millan MJ | β | 2002 | β |
| Molecular cloning and tissue distribution of mRNA encoding porcine 5-HT7 receptor and its comparison with the structure of other species. | Bhalla P et al. | β | 2002 | β |
| Molecular, pharmacological and functional diversity of 5-HT receptors. | Hoyer D et al. | β | 2002 | β |
| Mouse beta 3a- and beta 3b-adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways. | Hutchinson DS et al. | β | 2002 | β |
| Reconsideration of 5-hydroxytryptamine (5-HT)(7) receptor distribution using [(3)H]5-carboxamidotryptamine and [(3)H]8-hydroxy-2-(di-n-propylamino)tetraline: analysis in brain of 5-HT(1A) knockout and 5-HT(1A/1B) double-knockout mice. | Bonaventure P et al. | β | 2002 | β |
| Single cell laser dissection with molecular beacon polymerase chain reaction identifies 2A as the predominant serotonin receptor subtype in hypoglossal motoneurons. | Zhan G et al. | β | 2002 | β |
| The human 5-HT7 serotonin receptor splice variants: constitutive activity and inverse agonist effects. | Krobert KA et al. | β | 2002 | β |
| Cloning and expression analysis of a 5HT7-like serotonin receptor cDNA from mosquito Aedes aegypti female excretory and respiratory systems. | Pietrantonio PV et al. | β | 2001 | β |
| Cloning of the mouse 5-HT6 serotonin receptor and mutagenesis studies of the third cytoplasmic loop. | Kohen R et al. | β | 2001 | β |
| Distribution of 5-ht(5A), 5-ht(5B), 5-ht(6) and 5-HT(7) receptor mRNAs in the rat brain. | Kinsey AM et al. | β | 2001 | β |
| Localization of 5-HT(7) receptors in rat brain by immunocytochemistry, in situ hybridization, and agonist stimulated cFos expression. | Neumaier JF et al. | β | 2001 | β |
| Multiplicity of mechanisms of serotonin receptor signal transduction. | Raymond JR et al. | β | 2001 | β |
| Serotonergic gene expression and depression: implications for developing novel antidepressants. | Lesch KP | β | 2001 | β |
| The effect of SB-269970, a 5-HT(7) receptor antagonist, on 5-HT release from serotonergic terminals and cell bodies. | Roberts C et al. | β | 2001 | β |
| Variation of serotonergic gene expression: neurodevelopment and the complexity of response to psychopharmacologic drugs. | Lesch KP | β | 2001 | β |
| [(3)H]-SB-269970--A selective antagonist radioligand for 5-HT(7) receptors. | Thomas DR et al. | β | 2000 | β |
| 5-HT7 receptors: current knowledge and future prospects. | Vanhoenacker P et al. | β | 2000 | β |
| Characterisation of a 5-HT(7) binding site in mouse ileum. | Hemedah M et al. | β | 2000 | β |
| Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist. | Hagan JJ et al. | β | 2000 | β |
| Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. | Zhukovskaya NL et al. | β | 2000 | β |
| Diverse signalling by 5-hydroxytryptamine (5-HT) receptors. | Pauwels PJ | β | 2000 | β |
| Effect of p-chloroamphetamine on 5-HT1A and 5-HT7 serotonin receptor expression in rat brain. | GarcΓa-Osta A et al. | β | 2000 | β |
| Identification and characterization of a truncated variant of the 5-hydroxytryptamine(2A) receptor produced by alternative splicing. | Guest PC et al. | β | 2000 | β |
| Identification of the adenylyl cyclase-activating 5-hydroxytryptamine receptor subtypes expressed in the rat submandibular gland. | Bourdon DM et al. | β | 2000 | β |
| mRNA expression of serotonin receptors in cells of the immune tissues of the rat. | Stefulj J et al. | β | 2000 | β |
| Role of 5-HT in the regulation of the brain-pituitary-adrenal axis: effects of 5-HT on adrenocortical cells. | Contesse V et al. | β | 2000 | β |
| Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant. | Bender E et al. | β | 2000 | β |
| [3H]-Mesulergine labels 5-HT7 sites in rat brain and guinea-pig ileum but not rat jejunum. | Hemedah M et al. | β | 1999 | β |
| 7TM receptors: the splicing on the cake. | Kilpatrick GJ et al. | β | 1999 | β |
| Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. | Hedlund PB et al. | β | 1999 | β |
| Alternative splicing generates two isoforms of the beta3-adrenoceptor which are differentially expressed in mouse tissues. | Evans BA et al. | β | 1999 | β |
| Alternative-splicing of serotonin receptor isoforms in the pharynx and muscle of the parasitic nematode, Ascaris suum. | Huang X et al. | β | 1999 | β |
| A review of central 5-HT receptors and their function. | Barnes NM et al. | β | 1999 | β |
| Identification of a human 5-HT6 receptor variant produced by alternative splicing. | Olsen MA et al. | β | 1999 | β |
| Pharmacological and molecular characterization of 5-hydroxytryptamine(7) receptors in the rat adrenal gland. | Contesse V et al. | β | 1999 | β |
| Pindolol-insensitive [3H]-5-hydroxytryptamine binding in the rat hypothalamus; identity with 5-hydroxytryptamine7 receptors. | Clemett DA et al. | β | 1999 | β |
| 5-HT4 receptors: cloning and expression of new splice variants. | Claeysen S et al. | β | 1998 | β |
| A human serotonin-7 receptor pseudogene. | Qian IH et al. | β | 1998 | β |
| Function and distribution of three rat 5-hydroxytryptamine7 (5-HT7) receptor isoforms produced by alternative splicing. | Heidmann DE et al. | β | 1998 | β |
| Gs protein-coupled serotonin receptors: receptor isoforms and functional differences. | Hamblin MW et al. | β | 1998 | β |
| Involvement of 5-hydroxytryptamine7 receptors in inhibition of porcine myometrial contractility by 5-hydroxytryptamine. | Kitazawa T et al. | β | 1998 | β |
| Mutation screening of the 5-hydroxytryptamine7 receptor gene among Finnish alcoholics and controls. | Pesonen U et al. | β | 1998 | β |
| (R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl) propyl]benzenesulfonamide: the first selective 5-HT7 receptor antagonist. | Forbes IT et al. | β | 1998 | β |
| Role of serotonin in the immune system and in neuroimmune interactions. | MΓΆssner R et al. | β | 1998 | β |
| Selective labelling of 5-HT7 receptor recognition sites in rat brain using [3H]5-carboxamidotryptamine. | Stowe RL et al. | β | 1998 | β |
| Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor. | Baker LP et al. | β | 1998 | β |
| The molecular biology of serotonin receptors: therapeutic implications for the interface of mood and psychosis. | Kroeze WK et al. | β | 1998 | β |
| Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b). | Jasper JR et al. | β | 1997 | β |