Cleaning genotype data.
- Authors
- Broman, K W
- Year
- 1999
- Journal
- Genetic epidemiology
- PMID
- 10597416
- DOI
- 10.1002/gepi.1370170714
The identification of genes contributing to variation in complex phenotypes requires genetic data of high fidelity. Thus, the identification of pedigree and genotyping errors is a crucial prerequisite to the analysis of data from a genome scan for disease genes. The problem has been given little attention in most gene hunting papers; the focus has often been on eliminating mendelian inconsistencies in order that the analysis may proceed, rather than on achieving the best possible data. Though a number of computer programs are available to assist in the identification of genotyping and pedigree errors, the process is still not completely automated. While the Collaborative Study on the Genetics of Alcoholism (COGA) data set for GAW11 is completely compatible with Mendel's rules, there are still some errors present. We inspected the COGA data for the presence of additional errors, and identified five possible pedigree errors.
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| Quality control procedures for genome-wide association studies. | 2011 | 21234875 |
| Quality control and quality assurance in genotypic data for genome-wide association studies. | 2010 | 20718045 |
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| Quality Control Procedures for Genome-Wide Association Studies. | Truong VQ et al. | — | 2022 | → |
| Estimating the prevalence of nonpaternity in Germany. | Wolf M et al. | — | 2012 | → |
| Quality control procedures for genome-wide association studies. | Turner S et al. | — | 2011 | → |
| Quality control and quality assurance in genotypic data for genome-wide association studies. | Laurie CC et al. | — | 2010 | → |
| Statistical genetic issues for genome-wide association studies. | Weir BS | — | 2010 | → |
| Recent decline in nonpaternity rates: a cross-temporal meta-analysis. | Voracek M et al. | — | 2008 | → |
| Pedigree and genotype errors in the Framingham Heart Study. | Brush G et al. | — | 2003 | → |
| Relationship inference from trios of individuals, in the presence of typing error. | Sieberts SK et al. | — | 2002 | → |
| A transmission/disequilibrium test that allows for genotyping errors in the analysis of single-nucleotide polymorphism data. | Gordon D et al. | — | 2001 | → |