Influence of trait anxiety on inhibitory control in alcohol-dependent patients: simultaneous acquisition of ERPs and BOLD responses.
- Authors
- Karch, Susanne; Jäger, Lorenz; Karamatskos, Evangelos; Graz, Christian; Stammel, Andreas; Flatz, Wilhelm; Lutz, Jürgen; Holtschmidt-Täschner, Bettina; Genius, Just; Leicht, Gregor; Pogarell, Oliver; Born, Christine; Möller, Hans-Jürgen; Hegerl, Ulrich; Reiser, Maximilian; Soyka, Michael; Mulert, Christoph
- Year
- 2008
- Journal
- Journal of psychiatric research
- PMID
- 17826793
- DOI
- 10.1016/j.jpsychires.2007.07.016
Alcohol-dependence is often associated with comorbid psychiatric symptoms. However, the results concerning the influence of these symptoms on cognitive functioning in alcoholism are still inconsistent. The aim of this study was to determine performance monitoring in healthy volunteers and alcohol-dependent patients, and to assess the influence of trait anxiety on these processes. Sixteen healthy volunteers and 16 detoxified alcohol-dependent patients completed an auditory go/nogo paradigm. Functional magnetic resonance imaging, event-related potentials and behavioral data were acquired simultaneously. The patients were classified by median split based on level of self-rated trait anxiety (state-trait anxiety inventory; STAI). The results showed no significant differences regarding inhibition-associated electrophysiological and behavioral responses between alcohol-dependent patients with high-trait anxiety scores and alcohol-addicts with low-STAI scores. However, the functional MRI data revealed elevated activations during the response inhibition task especially in the middle frontal gyrus (BA 6/9), the superior frontal gyrus (BA 6/8/9) and the right inferior frontal gyrus, as well as temporo-parietal brain regions in patients with high-trait anxiety compared to non-anxious alcohol-addicts. Patients and healthy controls showed comparable results with regard to neural and behavioral responses. These results suggest that inhibitory control capacities of alcohol-dependent patients are not consistent: alcohol-addicts with high-trait anxiety ratings showed elevated neural responses compared to patients without any comorbid psychiatric symptoms. This may indicate that comorbid psychiatric symptoms need to be considered when assessing brain responses in alcohol-dependent patients.
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| Preliminary evidence for changes in frontoparietal network connectivity in the early abstinence period in alcohol use disorder: a longitudinal resting-state functional magnetic resonance imaging study. | van Oort J et al. | — | 2023 | → |
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| Emotionally valenced stimuli impact response inhibition in those with substance use disorder and co-occurring anxiety and depression symptoms. | Legrand AC et al. | — | 2020 | → |
| Stroop-related cerebellar and temporal activation is correlated with negative affect and alcohol use disorder severity. | Wilcox CE et al. | — | 2020 | → |
| Using connectivity-based real-time fMRI neurofeedback to modulate attentional and resting state networks in people with high trait anxiety. | Morgenroth E et al. | — | 2020 | → |
| Altered relationship between prefrontal glutamate and activation during cognitive control in people with high trait anxiety. | Morgenroth E et al. | — | 2019 | → |
| Compulsivity in Alcohol Use Disorder and Obsessive Compulsive Disorder: Implications for Neuromodulation. | Burchi E et al. | — | 2019 | → |
| Neural bases underlying the association between balanced time perspective and trait anxiety. | Wu H et al. | — | 2019 | → |
| Age and impulsive behavior in drug addiction: A review of past research and future directions. | Argyriou E et al. | — | 2018 | → |
| Behavioral and Brain Activity Indices of Cognitive Control Deficits in Binge Drinkers. | Molnar SM et al. | — | 2018 | → |
| Worry is associated with inefficient functional activity and connectivity in prefrontal and cingulate cortices during emotional interference. | Barker H et al. | — | 2018 | → |
| Clinical anxiety promotes excessive response inhibition. | Grillon C et al. | — | 2017 | → |
| Do alcohol-dependent patients show different neural activation during response inhibition than healthy controls in an alcohol-related fMRI go/no-go-task? | Czapla M et al. | — | 2017 | → |
| Elevated Behavioral Economic Demand for Alcohol in a Community Sample of Heavy Drinking Smokers. | Amlung M et al. | — | 2017 | → |
| Delta, theta, and alpha event-related oscillations in alcoholics during Go/NoGo task: Neurocognitive deficits in execution, inhibition, and attention processing. | Pandey AK et al. | — | 2016 | → |
| Sex differences in the relationship between heavy alcohol use, inhibition and performance monitoring: Disconnect between behavioural and brain functional measures. | Smith JL et al. | — | 2016 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| Cognitive control network function in alcohol use disorder before and during treatment with lorazepam. | Wilcox CE et al. | — | 2015 | → |
| Conflict anticipation in alcohol dependence - A model-based fMRI study of stop signal task. | Hu S et al. | — | 2015 | → |
| Left-handers look before they leap: handedness influences reactivity to novel Tower of Hanoi tasks. | Wright L et al. | — | 2015 | → |
| Cognitive control in alcohol use disorder: deficits and clinical relevance. | Wilcox CE et al. | — | 2014 | → |
| Data-driven analysis of simultaneous EEG/fMRI using an ICA approach. | Schmüser L et al. | — | 2014 | → |
| Deficits in behavioural inhibition in substance abuse and addiction: a meta-analysis. | Smith JL et al. | — | 2014 | → |
| Implicit processing of visual emotions is affected by sound-induced affective states and individual affective traits. | Quarto T et al. | — | 2014 | → |
| Response inhibition in alcohol-dependent patients and patients with depression/anxiety: a functional magnetic resonance imaging study. | Sjoerds Z et al. | — | 2014 | → |
| Systematic review of ERP and fMRI studies investigating inhibitory control and error processing in people with substance dependence and behavioural addictions. | Luijten M et al. | — | 2014 | → |
| Behavioral control in alcohol use disorders: relationships with severity. | Claus ED et al. | — | 2013 | → |
| Electroencephalography of response inhibition tasks: functional networks and cognitive contributions. | Huster RJ et al. | — | 2013 | → |
| Evidence of deficits in behavioural inhibition and performance monitoring in young female heavy drinkers. | Smith JL et al. | — | 2013 | → |
| Adolescent brain development and underage drinking in the United States: identifying risks of alcohol use in college populations. | Silveri MM | — | 2012 | → |
| Are left-handers really more anxious? | Wright L et al. | — | 2012 | → |
| How acute and chronic alcohol consumption affects brain networks: insights from multimodal neuroimaging. | Schulte T et al. | — | 2012 | → |
| Low family support perception: a 'social marker' of substance dependence? | Lemos Vde A et al. | — | 2012 | → |
| Response inhibition and reward anticipation in medication-naïve adults with attention-deficit/hyperactivity disorder: a within-subject case-control neuroimaging study. | Carmona S et al. | — | 2012 | → |
| Impulsivity and neural correlates of response inhibition in schizophrenia. | Kaladjian A et al. | — | 2011 | → |
| Sex differences in neural responses to stress and alcohol context cues. | Seo D et al. | — | 2011 | → |
| ERP indices for response inhibition are related to anxiety-related personality traits. | Sehlmeyer C et al. | — | 2010 | → |
| Exploring the relationship between depressive and anxiety symptoms and neuronal response to alcohol cues. | Feldstein Ewing SW et al. | — | 2010 | → |
| Neural correlates (ERP/fMRI) of voluntary selection in adult ADHD patients. | Karch S et al. | — | 2010 | → |
| Altered impulse control in alcohol dependence: neural measures of stop signal performance. | Li CS et al. | — | 2009 | → |
| Bilateral decrease in ventrolateral prefrontal cortex activation during motor response inhibition in mania. | Mazzola-Pomietto P et al. | — | 2009 | → |
| Hippocampal function during associative learning in patients with posttraumatic stress disorder. | Werner NS et al. | — | 2009 | → |
| The free choice whether or not to respond after stimulus presentation. | Karch S et al. | — | 2009 | → |