Reduced expression of circadian clock genes in male alcoholic patients.
- Authors
- Huang, Ming-Chyi; Ho, Chia-Wei; Chen, Chun-Hsin; Liu, Shing-Cheng; Chen, Chiao-Chicy; Leu, Sy-Jye
- Year
- 2010
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 20735373
- DOI
- 10.1111/j.1530-0277.2010.01278.x
BACKGROUND: There are clear interactions between chronic alcohol consumption and circadian rhythmicity that is regulated by several circadian clock genes. The altered expressions of these genes have been mainly described in animals. The mammalian master clock in the suprachiasmatic nuclei orchestrates the biological rhythms in peripheral tissues. As peripheral blood mononuclear cells (PBMCs) are the most accessible tissue clinically, we assessed the mRNA levels of these genes in patients with alcohol dependence (AD) undergoing alcohol-withdrawal (AW) treatment. METHODS: Twenty-two male patients fulfilled the DSM-IV diagnostic criteria of AD, and 12 comparison healthy control subjects were recruited. The patients with AD were further divided by the presence of delirium tremens (DTs), the most severe form of AW syndrome, into DT group and non-DT group. All the participants received blood withdrawal at 9 am, while the patients with AD had blood collection twice: on the next morning of admission (baseline) and on the seventh day. PBMCs were isolated from whole blood, and the mRNA expression profiles of hClock1, hBmal1, hPer1, hPer2, hCry1, and hCry2 were determined by quantitative real-time PCR. RESULTS: The baseline mRNA levels of the target circadian clock genes were markedly lower in patients with AD than in control subjects. After 1 week of alcohol detoxification, there were very limited restorations of discrete circadian gene expressions. DT group did not differ in the expression patterns of circadian clock genes from non-DT group. CONCLUSIONS: This is the first study demonstrating the overall lowering of circadian clock genes among patients with AD. The expression pattern is comparable between patients with and without DTs. Although preliminary with data at only one single time point, the observation of strikingly reduced mRNA levels supports the association between circadian clock gene dysregulation and chronic alcohol intake.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review). | Wang J et al. | β | 2026 | β |
| Timing matters: circadian rhythm disruption in alcohol-associated peripheral organ pathophysiology. | Bailey SM | β | 2026 | β |
| A Complex Relationship Among the Circadian Rhythm, Reward Circuit and Substance Use Disorder (SUD). | Samanta S et al. | β | 2024 | β |
| Altered circadian expression of clock genes and clock-regulatory epigenetic modifiers in saliva of children with fetal alcohol spectrum disorders. | Das U et al. | β | 2024 | β |
| Circadian clock disruption impairs immune oscillation in chronic endogenous hypercortisolism: a multi-level analysis from a multicentre clinical trial. | Hasenmajer V et al. | β | 2024 | β |
| Circadian Typology and Physical Activity in Young Adults with Gaming Disorder. | Hsu TW et al. | β | 2024 | β |
| Disrupted Circadian Rhythms and Substance Use Disorders: A Narrative Review. | Sharma P et al. | β | 2024 | β |
| Effect of Alcohol on Clock Synchrony and Tissue Circadian Homeostasis in Mice. | Santovito LS et al. | β | 2024 | β |
| Exploring gut microbiota diurnal fluctuation in alcohol-dependent patients with sleep disturbance. | Zhao K et al. | β | 2024 | β |
| Microglia, circadian rhythm and lifestyle factors. | Jiao H et al. | β | 2024 | β |
| Sexually dimorphic role of circadian clock genes in alcohol drinking behavior. | de Zavalia N et al. | β | 2023 | β |
| Chronotype and Sleep Quality in Obesity: How Do They Change After Menopause? | Verde L et al. | β | 2022 | β |
| Circadian geneβΓβenvironment perturbations influence alcohol drinking in Cryptochrome-deficient mice. | HΓΌhne A et al. | β | 2022 | β |
| KrΓΌppel-like factor 7 deficiency causes autistic-like behavior in mice via regulating Clock gene. | Tian H et al. | β | 2022 | β |
| Targeting the Maladaptive Effects of Binge Drinking on Circadian Gene Expression. | Grigsby K et al. | β | 2022 | β |
| The clock diet: a practical nutritional guide to manage obesity through chrononutrition. | Barrea L et al. | β | 2022 | β |
| The Impact of Sex, Circadian Disruption, and the Clock<sup>Ξ19/Ξ19</sup> Genotype on Alcohol Drinking in Mice. | Rizk AA et al. | β | 2022 | β |
| Circadian rhythms and substance use disorders: A bidirectional relationship. | Tamura EK et al. | β | 2021 | β |
| Dopamine D1 and D2 receptors are distinctly associated with rest-activity rhythms and drug reward. | Zhang R et al. | β | 2021 | β |
| How Psychoactive Drugs and the Circadian Clock Are Enlightening One Another. | Engmann O | β | 2021 | β |
| Alcohol suppresses cardiovascular diurnal variations in male normotensive rats: Role of reduced PER2 expression and CYP2E1 hyperactivity in the heart. | Katary M et al. | β | 2020 | β |
| Sexually dimorphic influence of the circadian clock gene<i>Bmal1</i>in the striatum on alcohol intake | de Zavalia N et al. | β | 2020 | β |
| Cannabidiol affects circadian clock core complex and its regulation in microglia cells. | Lafaye G et al. | β | 2019 | β |
| Effects of chronic cocaine exposure on the circadian rhythmic expression of the clock genes in reward-related brain areas in rats. | Wang DQ et al. | β | 2019 | β |
| The circadian clock and liver function in health and disease. | Mukherji A et al. | β | 2019 | β |
| The costs of negative affect attributable to alcohol consumption in later life: A within-between random longitudinal econometric model using UK Biobank. | Li C et al. | β | 2019 | β |
| Understanding Quantitative Circadian Regulations Are Crucial Towards Advancing Chronotherapy. | Chowdhury D et al. | β | 2019 | β |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | β | 2018 | β |
| Circadian Mechanisms in Alcohol Use Disorder and Tissue Injury. | Davis BT et al. | β | 2018 | β |
| Deep sequencing and miRNA profiles in alcohol-induced neuroinflammation and the TLR4 response in mice cerebral cortex. | UreΓ±a-Peralta JR et al. | β | 2018 | β |
| Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder. | Lindberg D et al. | β | 2018 | β |
| The human circadian clock from health to economics. | Koritala BSC et al. | β | 2018 | β |
| The role of CLOCK gene in psychiatric disorders: Evidence from human and animal research. | Schuch JB et al. | β | 2018 | β |
| <i>Drosophila</i>: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse. | De Nobrega AK et al. | β | 2017 | β |
| Learned motivation drives circadian physiology in the absence of the master circadian clock. | Rawashdeh O et al. | β | 2017 | β |
| Chronic Alcohol Consumption in Rats Leads to Desynchrony in Diurnal Rhythms and Molecular Clocks. | Guo R et al. | β | 2016 | β |
| Circadian rhythmicity in substance use disorder male patients with and without comorbid depression under ambulatory and therapeutic community treatment. | AntΓΊnez JM et al. | β | 2016 | β |
| Mutations in the circadian gene period alter behavioral and biochemical responses to ethanol in Drosophila. | Liao J et al. | β | 2016 | β |
| Night workers with circadian misalignment are susceptible to alcohol-induced intestinal hyperpermeability with social drinking. | Swanson GR et al. | β | 2016 | β |
| Nutrition and the circadian system. | Potter GD et al. | β | 2016 | β |
| Alcohol and lithium have opposing effects on the period and phase of the behavioral free-running activity rhythm. | Nascimento NF et al. | β | 2015 | β |
| Assessing ethanol's actions in the suprachiasmatic circadian clock using in vivo and in vitro approaches. | Prosser RA et al. | β | 2015 | β |
| Circadian clock genes: effects on dopamine, reward and addiction. | Parekh PK et al. | β | 2015 | β |
| Circadian Clocks in the Hematologic System. | Pritchett D et al. | β | 2015 | β |
| Clock genes Γ stress Γ reward interactions in alcohol and substance use disorders. | Perreau-Lenz S et al. | β | 2015 | β |
| Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light. | Ruby CL et al. | β | 2014 | β |
| Circadian rhythms and addiction: mechanistic insights and future directions. | Logan RW et al. | β | 2014 | β |
| Neurochemical mechanisms of alcohol withdrawal. | Becker HC et al. | β | 2014 | β |
| Chronic ethanol consumption disrupts the core molecular clock and diurnal rhythms of metabolic genes in the liver without affecting the suprachiasmatic nucleus. | Filiano AN et al. | β | 2013 | β |
| Circadian disruption: potential implications in inflammatory and metabolic diseases associated with alcohol. | Voigt RM et al. | β | 2013 | β |
| The role of clock in ethanol-related behaviors. | Ozburn AR et al. | β | 2013 | β |
| Altered expression of cytokine signaling pathway genes in peripheral blood cells of alcohol dependent subjects: preliminary findings. | Beech RD et al. | β | 2012 | β |
| Circadian genes, the stress axis, and alcoholism. | Sarkar DK | β | 2012 | β |
| Circadian typology: a comprehensive review. | Adan A et al. | β | 2012 | β |
| Inhibition of the casein-kinase-1-Ξ΅/Ξ΄/ prevents relapse-like alcohol drinking. | Perreau-Lenz S et al. | β | 2012 | β |
| Integration of the circadian and stress systems: influence of neuropeptides and implications for alcohol consumption. | Wong CC et al. | β | 2012 | β |
| Social rank, chronic ethanol self-administration, and diurnal pituitary-adrenal activity in cynomolgus monkeys. | Helms CM et al. | β | 2012 | β |
| Methylation analysis of circadian clock gene promoters in forensic autopsy specimens. | Nakatome M et al. | β | 2011 | β |
| mGluR7 genetics and alcohol: intersection yields clues for addiction. | Gyetvai B et al. | β | 2011 | β |