Statistical methods in genetic research on smoking.
- Authors
- Heath, A C; Madden, P A; Martin, N G
- Year
- 1998
- Journal
- Statistical methods in medical research
- PMID
- 9654640
- DOI
- 10.1177/096228029800700205
A growing body of evidence suggests that genetic factors have an important influence on the onset and course of smoking. Here we review some of the statistical methods that have been used to test for genetic influences on smoking behaviour, with a particular focus on studies of large national twin samples. We show how many of the hypotheses that have been tested using a genetic model-fitting approach have also been reformulated using logistic regression models that will be more familiar to epidemiologists. Such an approach is more easily extended to allow for sociocultural, as well as genetic, influences on smoking behaviour. Using either approach, data are consistent in indicating that certainly in men, and possibly in women, genetic factors play an important role in predicting which individuals who become cigarette smokers progress to being long-term persistent smokers.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Cross-Cultural Comparison of Genetic and Cultural Transmission of Smoking Initiation Using an Extended Twin Kinship Model. | Maes HH et al. | — | 2018 | → |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | — | 2017 | → |
| CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences. | Hoft NR et al. | — | 2011 | → |
| Interplay between heritability of smoking and environmental conditions? A comparison of two birth cohorts. | Vink JM et al. | — | 2011 | → |
| Association of CHRN genes with "dizziness" to tobacco. | Ehringer MA et al. | — | 2010 | → |
| Changes in genetic and environmental influences on the development of nicotine dependence and major depressive disorder from middle adolescence to early adulthood. | Tully EC et al. | — | 2010 | → |
| Pathways to cannabis abuse: a multi-stage model from cannabis availability, cannabis initiation and progression to abuse. | Gillespie NA et al. | — | 2009 | → |
| The genetic components of alcohol and nicotine co-addiction: from genes to behavior. | Schlaepfer IR et al. | — | 2008 | → |
| A possible smoking susceptibility locus on chromosome 11p12: evidence from sex-limitation linkage analyses in a sample of Australian twin families. | Morley KI et al. | — | 2006 | → |
| Extensions to the modeling of initiation and progression: applications to substance use and abuse. | Neale MC et al. | — | 2006 | → |
| Genetic and cultural transmission of smoking initiation: an extended twin kinship model. | Maes HH et al. | — | 2006 | → |
| Genetic architecture of smoking behavior: a study of Finnish adult twins. | Broms U et al. | — | 2006 | → |
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| Resiliency factors protecting against teenage alcohol use and smoking: influences of religion, religious involvement and values, and ethnicity in the Missouri Adolescent Female Twin Study. | Heath AC et al. | — | 1999 | → |
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