The dopamine hypothesis of the reinforcing properties of cocaine.
paper
Cited
Public
Unavailable
- Authors
- Kuhar, M J; Ritz, M C; Boja, J W
- Year
- 1991
- Journal
- Trends in neurosciences
- PMID
- 1719677
- DOI
- 10.1016/0166-2236(91)90141-g
A variety of evidence suggests a 'dopamine hypothesis' for the reinforcing properties of cocaine. This hypothesis proposes that cocaine binds at the dopamine transporter and mainly inhibits neurotransmitter re-uptake; the resulting potentiation of dopaminergic neurotransmission in mesolimbocortical pathways ultimately causes reinforcement. This model suggests potential medications for treatment of cocaine abuse and dependence. Some, but not all, pharmacological data in humans support the hypothesis and additional experimentation is needed.
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| Targeting drug transporters - combining in silico and in vitro approaches to predict in vivo. | Bahadduri PM et al. | β | 2010 | β |
| The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties. | Caldarone BJ et al. | β | 2010 | β |
| Transgenic mice in the study of drug addiction and the effects of psychostimulant drugs. | Sora I et al. | β | 2010 | β |
| Using In Vivo Electrochemistry to Study the Physiological Effects of Cocaine and Other Stimulants on the Drosophila melanogaster Dopamine Transporter. | Makos MA et al. | β | 2010 | β |
| Cocaine does not produce reward in absence of dopamine transporter inhibition. | Tilley MR et al. | β | 2009 | β |
| Combinations of cocaine with other dopamine uptake inhibitors: assessment of additivity. | Tanda G et al. | β | 2009 | β |
| Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion. | Jones JD et al. | β | 2009 | β |
| Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors. | Tanda G et al. | β | 2009 | β |
| Dopamine D1 receptor ligands: where are we now and where are we going. | Zhang J et al. | β | 2009 | β |
| Functional mutations in mouse norepinephrine transporter reduce sensitivity to cocaine inhibition. | Wei H et al. | β | 2009 | β |
| In vitro binding assays using (3)H nisoxetine and (3)H WIN 35,428 reveal selective effects of gonadectomy and hormone replacement in adult male rats on norepinephrine but not dopamine transporter sites in the cerebral cortex. | Meyers B et al. | β | 2009 | β |
| In vivo electrochemical measurements of exogenously applied dopamine in Drosophila melanogaster. | Makos MA et al. | β | 2009 | β |
| Neural mechanisms underlying drug-related cue distraction in active cocaine users. | Hester R et al. | β | 2009 | β |
| N-methyl amine-substituted fluoxetine derivatives: new dopamine transporter inhibitors. | Yoon YS et al. | β | 2009 | β |
| On the electronic structure of cocaine and its metabolites. | RincΓ³n DA et al. | β | 2009 | β |
| Positive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporter. | Navarro HA et al. | β | 2009 | β |
| Proline-directed phosphorylation of the dopamine transporter N-terminal domain. | Gorentla BK et al. | β | 2009 | β |
| Self-administration of cocaine-pentobarbital mixtures by rhesus monkeys. | Woolverton WL et al. | β | 2009 | β |
| Substance P and cocaine employ convergent mechanisms to depress excitatory synaptic transmission in the rat nucleus accumbens in vitro. | Kombian SB et al. | β | 2009 | β |
| Synthesis and structure-activity relationship of 3beta-(4-alkylthio, -methylsulfinyl, and -methylsulfonylphenyl)tropane and 3beta-(4-alkylthiophenyl)nortropane derivatives for monoamine transporters. | Jin C et al. | β | 2009 | β |
| Trafficking of dopamine transporters in psychostimulant actions. | Zahniser NR et al. | β | 2009 | β |
| Acute effects of cocaine on the neurobiology of cognitive control. | Garavan H et al. | β | 2008 | β |
| Antidepressant-like pharmacological profile of a novel triple reuptake inhibitor, (1S,2S)-3-(methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS). | Liang Y et al. | β | 2008 | β |
| Augmented D1 dopamine receptor signaling and immediate-early gene induction in adult striatum after prenatal cocaine. | Tropea TF et al. | β | 2008 | β |
| Cocaine disinhibits dopamine neurons in the ventral tegmental area via use-dependent blockade of GABA neuron voltage-sensitive sodium channels. | Steffensen SC et al. | β | 2008 | β |
| Design and synthesis of 2- and 3-substituted-3-phenylpropyl analogs of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: role of amino, fluoro, hydroxyl, methoxyl, methyl, methylene, and oxo substituents on affinity for the dopamine and serotonin transporters. | Hsin LW et al. | β | 2008 | β |
| Dopamine-beta hydroxylase polymorphism and cocaine addiction. | Guindalini C et al. | β | 2008 | β |
| Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction. | Rothman RB et al. | β | 2008 | β |
| Effects of estradiol on cocaine self-administration and cocaine discrimination by female rhesus monkeys. | Mello NK et al. | β | 2008 | β |
| Gender differences in zebrafish responses to cocaine withdrawal. | LΓ³pez PatiΓ±o MA et al. | β | 2008 | β |
| Influence of cocaine on ruptured intracranial aneurysms: a case control study of poor prognostic indicators. | Vannemreddy P et al. | β | 2008 | β |
| Long-term administration of cocaine or serotonin reuptake inhibitors results in anatomical and neurochemical changes in noradrenergic, dopaminergic, and serotonin pathways. | Horne MK et al. | β | 2008 | β |
| Neuropharmacology and behavior in planarians: translations to mammals. | Buttarelli FR et al. | β | 2008 | β |
| Nonhuman primate neuroimaging and cocaine medication development. | Howell LL | β | 2008 | β |
| Population pharmacokinetics, brain distribution, and pharmacodynamics of 2nd generation dopamine transporter selective benztropine analogs developed as potential substitute therapeutics for treatment of cocaine abuse. | Syed SA et al. | β | 2008 | β |
| Regionally selective changes in neurotransmitter receptors in the brain of the 5-HT1B knockout mouse. | Ase AR et al. | β | 2008 | β |
| Role of the dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuse. | Zhu J et al. | β | 2008 | β |
| Short-acting cocaine and long-acting GBR-12909 both elicit rapid dopamine uptake inhibition following intravenous delivery. | EspaΓ±a RA et al. | β | 2008 | β |
| Synthesis and monoamine transporter binding properties of 2beta-[3'-(substituted benzyl)isoxazol-5-yl]- and 2beta-[3'-methyl-4'-(substituted phenyl)isoxazol-5-yl]-3beta-(substituted phenyl)tropanes. | Jin C et al. | β | 2008 | β |
| Synthesis and receptor binding properties of 2beta-alkynyl and 2beta-(1,2,3-triazol)substituted 3beta-(substituted phenyl)tropane derivatives. | Jin C et al. | β | 2008 | β |
| The effects of cocaine on regional brain glucose metabolism is attenuated in dopamine transporter knockout mice. | Thanos PK et al. | β | 2008 | β |
| The novel N-substituted benztropine analog GA2-50 possesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate substitute medication for cocaine abuse. | Othman AA et al. | β | 2008 | β |
| The principles of agonist pharmacotherapy for psychostimulant dependence. | Shearer J | β | 2008 | β |
| The synthesis of bivalent 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)-8-heterobicyclo[3.2.1]octanes as probes for proximal binding sites on the dopamine and serotonin transporters. | Meltzer PC et al. | β | 2008 | β |
| Applicability of the dopamine and rate hypotheses in explaining the differences in behavioral pharmacology of the chloro-benztropine analogs: studies conducted using intracerebral microdialysis and population pharmacodynamic modeling. | Othman AA et al. | β | 2007 | β |
| Behavioral and neurochemical responses to cocaine in periadolescent and adult rats. | Frantz KJ et al. | β | 2007 | β |
| Cerebellar gray matter volume correlates with duration of cocaine use in cocaine-dependent subjects. | Sim ME et al. | β | 2007 | β |
| Cocaine reward and locomotion stimulation in mice with reduced dopamine transporter expression. | Tilley MR et al. | β | 2007 | β |
| DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods. | Gilbert KM et al. | β | 2007 | β |
| Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self-administration in rats. | PrzegaliΕski E et al. | β | 2007 | β |
| Gestational exposure to nicotine and monoamine oxidase inhibitors influences cocaine-induced locomotion in adolescent rats. | Franke RM et al. | β | 2007 | β |
| Maternal separation alters drug intake patterns in adulthood in rats. | Moffett MC et al. | β | 2007 | β |
| Methamphetamine functions as a positive and negative drug feature in a Pavlovian appetitive discrimination task. | Reichel CM et al. | β | 2007 | β |
| Modulation of the endocannabinoid system: therapeutic potential against cocaine dependence. | Tanda G | β | 2007 | β |
| Monoamine transporter as a target molecule for psychostimulants. | Sora I et al. | β | 2007 | β |
| Muscarinic preferential M(1) receptor antagonists enhance the discriminative-stimulus effects of cocaine in rats. | Tanda G et al. | β | 2007 | β |
| Neurotensin receptor antagonist administered during cocaine withdrawal decreases locomotor sensitization and conditioned place preference. | Felszeghy K et al. | β | 2007 | β |
| New 2alpha-tropane amides as potential PET ligands for the dopamine transporter. | Drewes B et al. | β | 2007 | β |
| New developments in the pharmacotherapy of cocaine abuse. | Preti A | β | 2007 | β |
| Post-error behavior in active cocaine users: poor awareness of errors in the presence of intact performance adjustments. | Hester R et al. | β | 2007 | β |
| QSAR studies and pharmacophore identification for arylsubstituted cycloalkenecarboxylic acid methyl esters with affinity for the human dopamine transporter. | Christensen HS et al. | β | 2007 | β |
| Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodyn. | Carey AN et al. | β | 2007 | β |
| Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters. | Petersen MD et al. | β | 2007 | β |
| Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. | Pham-Huu DP et al. | β | 2007 | β |
| Synthesis of enantiomerically pure milnacipran analogs and inhibition of dopamine, serotonin, and norepinephrine transporters. | Roggen H et al. | β | 2007 | β |
| 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. | Meltzer PC et al. | β | 2006 | β |
| 3-Aza-6,8-dioxabicyclo[3.2.1]octanes as new enantiopure heteroatom-rich tropane-like ligands of human dopamine transporter. | Cini N et al. | β | 2006 | β |
| Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. | Chen R et al. | β | 2006 | β |
| An antisense oligodeoxynucleotide to the mu opioid receptor attenuates cocaine-induced behavioral sensitization and reward in mice. | Hummel M et al. | β | 2006 | β |
| A randomized placebo-controlled trial of gabapentin for cocaine dependence. | Bisaga A et al. | β | 2006 | β |
| Biphasic alterations in serotonin-1B (5-HT1B) receptor function during abstinence from extended cocaine self-administration. | O'Dell LE et al. | β | 2006 | β |
| Changes in dopamine and acetylcholine in striatum of the awake rat after chronic treatment with a dopamine uptake blocker. | HernΓ‘ndez LF et al. | β | 2006 | β |
| Cholecystokinin-2 receptors couple to cAMP-protein kinase A to depress excitatory synaptic currents in rat nucleus accumbens in vitro. | Kombian SB et al. | β | 2006 | β |
| Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptors. | SchilstrΓΆm B et al. | β | 2006 | β |
| Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H(1) receptors. | Kulkarni SS et al. | β | 2006 | β |
| Design, synthesis, and preliminary SAR study of 3- and 6-side-chain-extended tetrahydro-pyran analogues of cis- and trans-(6-benzhydryl-tetrahydropyran-3-yl)-benzylamine. | Zhang S et al. | β | 2006 | β |
| Development of the dopamine transporter selective RTI-336 as a pharmacotherapy for cocaine abuse. | Carroll FI et al. | β | 2006 | β |
| Dopamine-1 receptor agonist, but not cocaine, modulates sigma(1) gene expression in SVG cells. | Ben-Ami O et al. | β | 2006 | β |
| Dopamine-2 receptors in the arcuate nucleus modulate cocaine-seeking behavior. | Doron R et al. | β | 2006 | β |
| Dopamine uptake and cocaine binding mechanisms: the involvement of charged amino acids from the transmembrane domains of the human dopamine transporter. | Dar DE et al. | β | 2006 | β |
| Effects of the selective delta opioid agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeys. | Do Carmo GP et al. | β | 2006 | β |
| Enhancement of hippocampal long-term potentiation induced by cocaine self-administration is maintained during the extinction of this behavior. | del Olmo N et al. | β | 2006 | β |
| Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters. | Zhang S et al. | β | 2006 | β |
| Hierarchical clustering analysis of flexible GBR 12909 dialkyl piperazine and piperidine analogs. | Gilbert KM et al. | β | 2006 | β |
| Identification of a noradrenaline-rich subdivision of the human nucleus accumbens. | Tong J et al. | β | 2006 | β |
| Improved 3D-QSAR CoMFA of the dopamine transporter blockers with multiple conformations using the genetic algorithm. | Yuan H et al. | β | 2006 | β |
| Interactions of cocaine with dopamine uptake inhibitors or dopamine releasers in rats discriminating cocaine. | Li SM et al. | β | 2006 | β |
| In vivo characterization of the pharmacokinetics and pharmacological properties of [11C]-(+)-PHNO in rats using an intracerebral beta-sensitive system. | Galineau L et al. | β | 2006 | β |
| Noradrenaline is necessary for the hedonic properties of addictive drugs. | Jasmin L et al. | β | 2006 | β |
| Olanzapine-induced suppression of cocaine self-administration in rhesus monkeys. | Howell LL et al. | β | 2006 | β |
| Pharmacophore-based discovery of ligands for drug transporters. | Chang C et al. | β | 2006 | β |
| Reduced psychostimulant effects on dopamine dynamics in the nucleus accumbens of mu-opioid receptor knockout mice. | Mathon DS et al. | β | 2006 | β |
| Singular value decomposition of torsional angles of analogs of the dopamine reuptake inhibitor GBR 12909. | Fiorentino A et al. | β | 2006 | β |
| Structure-activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter. | Boos TL et al. | β | 2006 | β |
| The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys. | Claytor R et al. | β | 2006 | β |
| The norepinephrine transporter in physiology and disease. | BΓΆnisch H et al. | β | 2006 | β |
| The role of amine oxidases in xenobiotic metabolism. | Gong B et al. | β | 2006 | β |
| The role of CART in the reward/reinforcing properties of psychostimulants. | Jaworski JN et al. | β | 2006 | β |
| A comprehensive atlas of the topography of functional groups of the dopamine transporter. | Volz TJ et al. | β | 2005 | β |
| Acute and chronic corticotropin-releasing factor 1 receptor blockade inhibits cocaine-induced dopamine release: correlation with dopamine neuron activity. | Lodge DJ et al. | β | 2005 | β |
| Alicyclic beta-amino acids in Medicinal Chemistry. | Kuhl A et al. | β | 2005 | β |
| Analgesic substances derived from natural products (natureceuticals). | McCurdy CR et al. | β | 2005 | β |
| A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine binding. | Sen N et al. | β | 2005 | β |
| Blunted response to cocaine in the Flinders hypercholinergic animal model of depression. | Fagergren P et al. | β | 2005 | β |
| Cholecystokinin inhibits evoked inhibitory postsynaptic currents in the rat nucleus accumbens indirectly through gamma-aminobutyric acid and gamma-aminobutyric acid type B receptors. | Kombian SB et al. | β | 2005 | β |
| Cocaine and methamphetamine produce different patterns of subjective and cardiovascular effects. | Newton TF et al. | β | 2005 | β |
| Different effects of valproate on methamphetamine- and cocaine-induced behavioral sensitization in mice. | Li JX et al. | β | 2005 | β |
| Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner. | Zhang S et al. | β | 2005 | β |
| Effects of 4'-chloro-3 alpha-(diphenylmethoxy)-tropane on mesostriatal, mesocortical, and mesolimbic dopamine transmission: comparison with effects of cocaine. | Tanda G et al. | β | 2005 | β |
| Effects of low- and high-nicotine cigarette smoking on mood states and the HPA axis in men. | Mendelson JH et al. | β | 2005 | β |
| Effects of the mixed mu/kappa opioid nalbuphine on cocaine-induced changes in subjective and cardiovascular responses in men. | Mello NK et al. | β | 2005 | β |
| Enantioselective synthesis of (2R,3R)- and (2S,3S)-2- [(3-chlorophenyl)-(2-methoxyphenoxy)methyl]morpholine. | Harding WW et al. | β | 2005 | β |
| Endogenous kappa-opioid receptor systems regulate mesoaccumbal dopamine dynamics and vulnerability to cocaine. | Chefer VI et al. | β | 2005 | β |
| Enhanced behavioral response to repeated-dose cocaine in adolescent rats. | Caster JM et al. | β | 2005 | β |
| Identification of a dopamine transporter ligand that blocks the stimulant effects of cocaine. | Desai RI et al. | β | 2005 | β |
| Increased gabaergic input to ventral tegmental area dopaminergic neurons associated with decreased cocaine reinforcement in mu-opioid receptor knockout mice. | Mathon DS et al. | β | 2005 | β |
| Interaction of cocaine and dopamine transporter inhibitors on behavior and neurochemistry in monkeys. | Ginsburg BC et al. | β | 2005 | β |
| In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys. | Wilcox KM et al. | β | 2005 | β |
| Kappa opioids as potential treatments for stimulant dependence. | Prisinzano TE et al. | β | 2005 | β |
| N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands. | Grundt P et al. | β | 2005 | β |
| Neither non-contingent electric footshock nor administered corticosterone facilitate the acquisition of methamphetamine self-administration. | Moffett MC et al. | β | 2005 | β |
| Outcome study of kleptomania patients treated with naltrexone: a chart review. | Grant JE | β | 2005 | β |
| Pharmacological aspects of the combined use of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and gamma-hydroxybutyric acid (GHB): a review of the literature. | Uys JD et al. | β | 2005 | β |
| Place conditioning and locomotor effects of N-substituted, 4',4''-difluorobenztropine analogs in rats. | Li SM et al. | β | 2005 | β |
| Relationship between in vivo occupancy at the dopamine transporter and behavioral effects of cocaine, GBR 12909 [1-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine], and benztropine analogs. | Desai RI et al. | β | 2005 | β |
| Serotonin-transporter mediated efflux: a pharmacological analysis of amphetamines and non-amphetamines. | Hilber B et al. | β | 2005 | β |
| Synthesis and monoamine transporter binding properties of 3beta-(3',4'-disubstituted phenyl)tropane-2beta-carboxylic acid methyl esters. | Carroll FI et al. | β | 2005 | β |
| Synthesis and pharmacology of 6-substituted benztropines: discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter. | Simoni D et al. | β | 2005 | β |
| The H3 antagonist thioperamide reveals conditioned preference for a context associated with an inactive small dose of cocaine in C57BL/6J mice. | Brabant C et al. | β | 2005 | β |
| The interaction of methylphenidate and benztropine with the dopamine transporter is different than other substrates and ligands. | Dar DE et al. | β | 2005 | β |
| The "ups and downs" of signaling cascades in addiction. | Ron D et al. | β | 2005 | β |
| 2,3-disubstituted 6-azabicyclo[3.2.1]octanes as novel dopamine transporter inhibitors. | Quirante J et al. | β | 2004 | β |
| Activation of the cGMP pathway in dopaminergic structures reduces cocaine-induced EGR-1 expression and locomotor activity. | Jouvert P et al. | β | 2004 | β |
| Agonist-like, replacement pharmacotherapy for stimulant abuse and dependence. | Grabowski J et al. | β | 2004 | β |
| Characterization of dopamine transport in crude synaptosomes prepared from rat medial prefrontal cortex. | Williams JM et al. | β | 2004 | β |
| Cholecystokinin activates CCKB receptors to excite cells and depress EPSCs in the rat rostral nucleus accumbens in vitro. | Kombian SB et al. | β | 2004 | β |
| CoMFA study of piperidine analogues of cocaine at the dopamine transporter: exploring the binding mode of the 3 alpha-substituent of the piperidine ring using pharmacophore-based flexible alignment. | Yuan H et al. | β | 2004 | β |
| Conformational analysis of methylphenidate: comparison of molecular orbital and molecular mechanics methods. | Gilbert KM et al. | β | 2004 | β |
| Covalent and noncovalent chemical modifications of arginine residues decrease dopamine transporter activity. | Volz TJ et al. | β | 2004 | β |
| Dopamine and alcoholism: neurobiological basis of ethanol abuse. | Tupala E et al. | β | 2004 | β |
| Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging. | Lindsey KP et al. | β | 2004 | β |
| Effects of N-substituted analogs of benztropine: diminished cocaine-like effects in dopamine transporter ligands. | Katz JL et al. | β | 2004 | β |
| Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene expression in rat CNS. | Di Benedetto M et al. | β | 2004 | β |
| Fast onset of dopamine uptake inhibition by intravenous cocaine. | Mateo Y et al. | β | 2004 | β |
| Fragmentation pathway of dopamine transporter ligands: N-substituted-2beta-carbomethoxy-3beta-phenylnortropane derivatives. | Mavel S et al. | β | 2004 | β |
| Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine transporters. | Kolhatkar R et al. | β | 2004 | β |
| Historical review: Molecular and cellular mechanisms of opiate and cocaine addiction. | Nestler EJ | β | 2004 | β |
| Individual differences in cocaine- and amphetamine-induced activation of male Sprague-Dawley rats: contribution of the dopamine transporter. | Briegleb SK et al. | β | 2004 | β |
| L-arginine increases dopamine transporter activity in rat striatum via a nitric oxide synthase-dependent mechanism. | Volz TJ et al. | β | 2004 | β |
| Lmo mutants reveal a novel role for circadian pacemaker neurons in cocaine-induced behaviors. | Tsai LT et al. | β | 2004 | β |
| Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters. | Miller DK et al. | β | 2004 | β |
| Molecular mechanisms underlying the rewarding effects of cocaine. | Hall FS et al. | β | 2004 | β |
| Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers. | Carroll FI et al. | β | 2004 | β |
| Nicotine-induced dopamine release in the nucleus accumbens is inhibited by the novel AMPA antagonist ZK200775 and the NMDA antagonist CGP39551. | Kosowski AR et al. | β | 2004 | β |
| Nicotinic receptor modulation of dopamine transporter function in rat striatum and medial prefrontal cortex. | Middleton LS et al. | β | 2004 | β |
| N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux. | Khoshbouei H et al. | β | 2004 | β |
| Perspectives for the development of animal models of bipolar disorder. | Machado-Vieira R et al. | β | 2004 | β |
| Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters. | Shen HW et al. | β | 2004 | β |
| Relationship of serum prolactin with severity of drug use and treatment outcome in cocaine dependence. | Patkar AA et al. | β | 2004 | β |
| Role of serotonin in cocaine effects in mice with reduced dopamine transporter function. | Mateo Y et al. | β | 2004 | β |
| Role of the dopamine transporter in the differential cocaine-induced locomotor activation of inbred long-sleep and short-sleep mice. | Hanania T et al. | β | 2004 | β |
| Selection of 2'-fluoro-modified RNA aptamers for alleviation of cocaine and MK-801 inhibition of the nicotinic acetylcholine receptor. | Cui Y et al. | β | 2004 | β |
| Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters. | Zhang S et al. | β | 2004 | β |
| Structure and function of extracellular loop 4 of the serotonin transporter as revealed by cysteine-scanning mutagenesis. | Mitchell SM et al. | β | 2004 | β |
| Synthesis of 8-thiabicyclo[3.2.1]oct-2-enes and their binding affinity for the dopamine and serotonin transporters. | Meltzer PC et al. | β | 2004 | β |
| The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor. | Grundt P et al. | β | 2004 | β |
| The somatodendritic release of dopamine in the ventral tegmental area and its regulation by afferent transmitter systems. | Adell A et al. | β | 2004 | β |
| Transdermal nicotine maintenance attenuates the subjective and reinforcing effects of intravenous nicotine, but not cocaine or caffeine, in cigarette-smoking stimulant abusers. | Sobel BF et al. | β | 2004 | β |
| Transdermal selegiline and intravenous cocaine: safety and interactions. | Houtsmuller EJ et al. | β | 2004 | β |
| Uptake inhibitors but not substrates induce protease resistance in extracellular loop two of the dopamine transporter. | Gaffaney JD et al. | β | 2004 | β |
| Voltammetric assessment of dopamine clearance in the absence of the dopamine transporter: no contribution of other transporters in core or shell of nucleus accumbens. | Mateo Y et al. | β | 2004 | β |
| 2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy. | Carroll FI | β | 2003 | β |
| 2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors. | Sakamuri S et al. | β | 2003 | β |
| Acute effects of D-amphetamine on progressive-ratio performance maintained by cigarette smoking and money. | Sigmon SC et al. | β | 2003 | β |
| A pilot trial of olanzapine for the treatment of cocaine dependence. | Kampman KM et al. | β | 2003 | β |
| Cardiovascular disorders associated with cocaine use: myths and truths. | Knuepfer MM | β | 2003 | β |
| Design, synthesis, and activity of novel cis- and trans-3,6-disubstituted pyran biomimetics of 3,6-disubstituted piperidine as potential ligands for the dopamine transporter. | Zhang S et al. | β | 2003 | β |
| Development, maintenance and temporal pattern of self-administration maintained by ecstasy (MDMA) in rats. | Schenk S et al. | β | 2003 | β |
| Dopamine mediation of positive reinforcing effects of amphetamine in stimulant naΓ―ve healthy volunteers: results from a large cohort. | Abi-Dargham A et al. | β | 2003 | β |
| Dopamine receptors and transporters in the brain reward circuits of type 1 and 2 alcoholics measured with human whole hemisphere autoradiography. | Tupala E et al. | β | 2003 | β |
| Dopamine transporter as target for drug development of cocaine dependence medications. | Dutta AK et al. | β | 2003 | β |
| Effect of HD-23, a potent long acting cocaine-analog, on cocaine self-administration in rats. | Roberts DC et al. | β | 2003 | β |
| Effects of a dopamine D3 receptor ligand, BP 897, on acquisition and expression of food-, morphine-, and cocaine-induced conditioned place preference, and food-seeking behavior in rats. | Duarte C et al. | β | 2003 | β |
| Effects of chronic d-amphetamine treatment on cocaine- and food-maintained responding under a progressive-ratio schedule in rhesus monkeys. | Negus SS et al. | β | 2003 | β |
| Effects of chronic d-amphetamine treatment on cocaine- and food-maintained responding under a second-order schedule in rhesus monkeys. | Negus SS et al. | β | 2003 | β |
| Effects of intravenous cocaine and cigarette smoking on luteinizing hormone, testosterone, and prolactin in men. | Mendelson JH et al. | β | 2003 | β |
| Effects of mixed-action kappa/mu opioids on cocaine self-administration and cocaine discrimination by rhesus monkeys. | Bowen CA et al. | β | 2003 | β |
| Effects of single and dual administration of cocaine and ethanol on opioid and ORL1 receptor expression in rat CNS: an autoradiographic study. | Rosin A et al. | β | 2003 | β |
| High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo. | Ghorai SK et al. | β | 2003 | β |
| Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine. | Kolhatkar RB et al. | β | 2003 | β |
| Intra-accumbal injection of CART (cocaine-amphetamine regulated transcript) peptide reduces cocaine-induced locomotor activity. | Jaworski JN et al. | β | 2003 | β |
| In vivo interaction of cocaine with the dopamine transporter as measured by voltammetry. | Greco PG et al. | β | 2003 | β |
| Mixed cocaine agonist/antagonist properties of (+)-methyl 4beta-(4-chlorophenyl)-1-methylpiperidine-3alpha-carboxylate, a piperidine-based analog of cocaine. | Kozikowski AP et al. | β | 2003 | β |
| Pharmacogenetics of monoamine transporters. | Glatt CE et al. | β | 2003 | β |
| Place conditioning: age-related changes in the rewarding and aversive effects of alcohol. | Philpot RM et al. | β | 2003 | β |
| Reduced behavioral effects of cocaine in heterozygous brain-derived neurotrophic factor (BDNF) knockout mice. | Hall FS et al. | β | 2003 | β |
| Sigma receptors: potential medications development target for anti-cocaine agents. | Matsumoto RR et al. | β | 2003 | β |
| Stimulant and reinforcing effects of cocaine in monoamine transporter knockout mice. | Rocha BA | β | 2003 | β |
| Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter. | Zou MF et al. | β | 2003 | β |
| Substance P depresses excitatory synaptic transmission in the nucleus accumbens through dopaminergic and purinergic mechanisms. | Kombian SB et al. | β | 2003 | β |
| Synthesis and biological activity of 2-carbomethoxy-3-catechol-8-azabicyclo[3.2.1]octanes. | Meltzer PC et al. | β | 2003 | β |
| Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents. | Hsin LW et al. | β | 2003 | β |
| Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum. | Kimmel HL et al. | β | 2003 | β |
| 5-HT(6) receptor antagonism potentiates the behavioral and neurochemical effects of amphetamine but not cocaine. | Frantz KJ et al. | β | 2002 | β |
| Acute administration of cocaine regulates the phosphorylation of serine-19, -31 and -40 in tyrosine hydroxylase. | Jedynak JP et al. | β | 2002 | β |
| Acute cocaine differentially alters accumbens and striatal dopamine clearance in low and high cocaine locomotor responders: behavioral and electrochemical recordings in freely moving rats. | Sabeti J et al. | β | 2002 | β |
| Amantadine treatment for cocaine-dependent patients with severe withdrawal symptoms. | Kampman KM | β | 2002 | β |
| Benzo- and cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. | Houlihan WJ et al. | β | 2002 | β |
| Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. | Chefer VI et al. | β | 2002 | β |
| Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. | Hall FS et al. | β | 2002 | β |
| Cocaine, reward, movement and monoamine transporters. | Uhl GR et al. | β | 2002 | β |
| Design and synthesis of an irreversible dopamine-sparing cocaine antagonist. | Meltzer PC et al. | β | 2002 | β |
| Determination of the benztropine analog AHN-1055, a dopamine uptake inhibitor, in rat plasma and brain by high-performance liquid chromatography with ultraviolet absorbance detection. | Raje S et al. | β | 2002 | β |
| Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine. | Hsin LW et al. | β | 2002 | β |
| Differential rat brain expression of EGR proteins and of the transcriptional corepressor NAB in response to acute or chronic cocaine administration. | Jouvert P et al. | β | 2002 | β |
| Discovery of substituted 3,4-diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol. | Enyedy IJ et al. | β | 2002 | β |
| Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum. | Kim DS et al. | β | 2002 | β |
| Dopaminergic effects after chronic treatment with nandrolone visualized in rat brain by positron emission tomography. | Kindlundh AM et al. | β | 2002 | β |
| Double-blind placebo-controlled trial of methylphenidate in the treatment of adult ADHD patients with comorbid cocaine dependence. | Schubiner H et al. | β | 2002 | β |
| Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice. | Huotari M et al. | β | 2002 | β |
| Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules. | Dutta AK et al. | β | 2002 | β |
| Further studies on conformationally constrained tricyclic tropane analogues and their uptake inhibition at monoamine transporter sites: synthesis of (Z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes as a novel class of serotonin transporter inhibitors. | Zhang A et al. | β | 2002 | β |
| Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines. | Ananthan S et al. | β | 2002 | β |
| Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. | Houlihan WJ et al. | β | 2002 | β |
| Nifedipine potentiates the toxic effects of cocaine in mice. | Ansah TA et al. | β | 2002 | β |
| Novel (bisarylmethoxy)butylpiperidine analogues as neurotransmitter transporter inhibitors with activity at dopamine receptor sites. | Choi SW et al. | β | 2002 | β |
| [Pharmacology of monoamine neurotransmitter transporters]. | Dohi T et al. | β | 2002 | β |
| Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole. | Newman AH et al. | β | 2002 | β |
| Reduction of cocaine place preference in mice lacking the protein phosphatase 1 inhibitors DARPP 32 or Inhibitor 1. | Zachariou V et al. | β | 2002 | β |
| Serotonergic attenuation of the reinforcing and neurochemical effects of cocaine in squirrel monkeys. | Czoty PW et al. | β | 2002 | β |
| Serum prolactin and response to treatment among cocaine-dependent individuals. | Patkar AA et al. | β | 2002 | β |
| SKF-82958 is a subtype-selective estrogen receptor-alpha (ERalpha ) agonist that induces functional interactions between ERalpha and AP-1. | Walters MR et al. | β | 2002 | β |
| Social rank and vulnerability to drug abuse. | Kuhar MJ | β | 2002 | β |
| The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression. | Zhang D et al. | β | 2002 | β |
| Three-dimensional quantitative structure-activity relationships of mazindol analogues at the dopamine transporter. | Kulkarni SS et al. | β | 2002 | β |
| Traumatic brain injury reduces dopamine transporter protein expression in the rat frontal cortex. | Yan HQ et al. | β | 2002 | β |
| [3H]MFZ 2-12: a novel radioligand for the dopamine transporter. | Newman AH et al. | β | 2001 | β |
| Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. | Rothman RB et al. | β | 2001 | β |
| CART peptide-immunoreactive projection from the nucleus accumbens targets substantia nigra pars reticulata neurons in the rat. | Dallvechia-Adams S et al. | β | 2001 | β |
| Chronic morphine treatment exaggerates the suppressive effects of sucrose and cocaine, but not lithium chloride, on saccharin intake in Sprague-Dawley rats. | Grigson PS et al. | β | 2001 | β |
| C-type natriuretic peptide (CNP) regulates cocaine-induced dopamine increase and immediate early gene expression in rat brain. | Thiriet N et al. | β | 2001 | β |
| Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype. | Robarge MJ et al. | β | 2001 | β |
| Different times of withdrawal from cocaine administration cause changes in muscarinic and dopaminergic receptors in rat premotor cortex. | MacΓͺdo DS et al. | β | 2001 | β |
| Dual incorporation of photoaffinity ligands on dopamine transporters implicates proximity of labeled domains. | Vaughan RA et al. | β | 2001 | β |
| Effects of cocaine on luteinizing hormone in women during the follicular and luteal phases of the menstrual cycle and in men. | Mendelson JH et al. | β | 2001 | β |
| Effects of kappa-opioid receptor agonists on long-term cocaine use and dopamine neurotransmission. | Collins SL et al. | β | 2001 | β |
| Effects of repeated GBR 12909 administration on brain stimulation reward. | Melnick SM et al. | β | 2001 | β |
| Hypolocomotor effects of acute and daily d-amphetamine in mice lacking the dopamine transporter. | Spielewoy C et al. | β | 2001 | β |
| Inhibition of MAO-A fails to alter cocaine-induced increases in extracellular dopamine and norepinephrine in rat nucleus accumbens. | Pepper JP et al. | β | 2001 | β |
| Locomotor stimulant effects of novel phenyltropanes in the mouse. | Kimmel HL et al. | β | 2001 | β |
| Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan. | Neumeyer JL et al. | β | 2001 | β |
| Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. | Sora I et al. | β | 2001 | β |
| Molecular modeling, structure--activity relationships and functional antagonism studies of 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketones as a novel class of dopamine transporter inhibitors. | Wang S et al. | β | 2001 | β |
| Neuroendocrine effects of d-fenfluramine and bromocriptine following repeated smoked cocaine in humans. | Haney M et al. | β | 2001 | β |
| Novel tropane-based irreversible ligands for the dopamine transporter. | Zou MF et al. | β | 2001 | β |
| Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission. | Wu Q et al. | β | 2001 | β |
| Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters. | Matsumoto RR et al. | β | 2001 | β |
| RTI-76, an irreversible inhibitor of dopamine transporter binding, increases locomotor activity in the rat at high doses. | Kimmel HL et al. | β | 2001 | β |
| Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes. | Newman AH et al. | β | 2001 | β |
| Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters. | Dutta AK et al. | β | 2001 | β |
| Substance P modulates cocaine-evoked dopamine overflow in the striatum of the rat brain. | Kraft M et al. | β | 2001 | β |
| Synthesis and pharmacology of site specific cocaine abuse treatment agents: a new synthetic methodology for methylphenidate analogs based on the Blaise reaction. | Deutsch HM et al. | β | 2001 | β |
| Synthesis and preliminary characterization of a high-affinity novel radioligand for the dopamine transporter. | Dutta AK et al. | β | 2001 | β |
| Synthesis of 6- and 7- hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. | Meltzer PC et al. | β | 2001 | β |
| The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter. | Reith ME et al. | β | 2001 | β |
| Toward a molecular understanding of psychostimulant actions using genetically engineered dopamine receptor knockout mice as model systems. | Zhang J et al. | β | 2001 | β |
| 1-[1-(2-Benzo[b]thiopheneyl)cyclohexyl]piperidine hydrochloride (BTCP) yields two active primary metabolites in vivo. Identification and quantification of BTCP primary metabolites in mice plasma, urine, and brain and their affinity for the neuronal dopamine transporter. | Deleuze-Masquefa C et al. | β | 2000 | β |
| 2-Carbomethoxy-3-aryl-8-bicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters. | Meltzer PC et al. | β | 2000 | β |
| 2D QSAR modeling and preliminary database searching for dopamine transporter inhibitors using genetic algorithm variable selection of Molconn Z descriptors. | Hoffman BT et al. | β | 2000 | β |
| 3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes inhibit WIN 35,428 binding potently and selectively at the dopamine transporter. | Meltzer PC et al. | β | 2000 | β |
| 7-Nitroindazole blocks nicotine-induced conditioned place preference but not LiCl-induced conditioned place aversion. | Martin JL et al. | β | 2000 | β |
| Alkylation of rat dopamine transporters and blockade of dopamine uptake by EEDQ. | Tarazi FI et al. | β | 2000 | β |
| Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism. | Saunders C et al. | β | 2000 | β |
| Amphetamine withdrawal alters bistable states and cellular coupling in rat prefrontal cortex and nucleus accumbens neurons recorded in vivo. | Onn SP et al. | β | 2000 | β |
| An enantioselective synthesis and biobehavioral evaluation of 7-fluoro-3-(p-fluorophenyl)-2-propyltropanes. | Prakash KR et al. | β | 2000 | β |
| An intermediate state of the gamma-aminobutyric acid transporter GAT1 revealed by simultaneous voltage clamp and fluorescence. | Li M et al. | β | 2000 | β |
| Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor. | Xu M et al. | β | 2000 | β |
| C-fos and egr-1 immediate-early gene induction by cocaine and cocaethylene in rat brain: a comparative study. | Thiriet N et al. | β | 2000 | β |
| Chemistry, design, and structure-activity relationship of cocaine antagonists. | Singh S | β | 2000 | β |
| Chronic psychosocial stress reduces the density of dopamine transporters. | Isovich E et al. | β | 2000 | β |
| Cocaine and the kidney: a synthesis of pathophysiologic and clinical perspectives. | Nzerue CM et al. | β | 2000 | β |
| Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies. | Wang S et al. | β | 2000 | β |
| Dopamine-independent action of cocaine on striatal and accumbal neurons. | Kiyatkin EA et al. | β | 2000 | β |
| Dopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila. | Bainton RJ et al. | β | 2000 | β |
| E-state modeling of dopamine transporter binding. Validation of the model for a small data set. | Maw HH et al. | β | 2000 | β |
| Highly selective chiral N-substituted 3alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues for the dopamine transporter: synthesis and comparative molecular field analysis. | Robarge MJ et al. | β | 2000 | β |
| Improving the quality of substance dependency treatment with pharmacotherapy. | Boyarsky BK et al. | β | 2000 | β |
| Increased rewarding properties of morphine in dopamine-transporter knockout mice. | Spielewoy C et al. | β | 2000 | β |
| Individual differences among cocaine users. | GunnarsdΓ³ttir ED et al. | β | 2000 | β |
| Interactions between kappa opioid agonists and cocaine. Preclinical studies. | Mello NK et al. | β | 2000 | β |
| Intracranial aneurysms and cocaine abuse: analysis of prognostic indicators. | Nanda A et al. | β | 2000 | β |
| Kappa opioid agonists as targets for pharmacotherapies in cocaine abuse. | Neumeyer JL et al. | β | 2000 | β |
| Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine. | Thompson AC et al. | β | 2000 | β |
| Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists. | Castanon N et al. | β | 2000 | β |
| Neurochemical changes in brain serotonin neurons in immature and adult offspring prenatally exposed to cocaine. | Cabrera-Vera TM et al. | β | 2000 | β |
| Novel in vivo electrophysiological assay for the effects of cocaine and putative "cocaine antagonists" on dopamine transporter activity of substantia nigra and ventral tegmental area dopamine neurons. | Hinerth MA et al. | β | 2000 | β |
| Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. | Kiyatkin EA et al. | β | 2000 | β |
| Probing the role of the dopamine D1 receptor in psychostimulant addiction. | Zhang J et al. | β | 2000 | β |
| Serotonin transporters upregulate with chronic cocaine use. | Mash DC et al. | β | 2000 | β |
| Slow-onset, long-duration 3-(3',4'-dichlorophenyl)-1-indanamine monoamine reuptake blockers as potential medications to treat cocaine abuse. | Froimowitz M et al. | β | 2000 | β |
| Structural domains of chimeric dopamine-noradrenaline human transporters involved in the Na(+)- and Cl(-)-dependence of dopamine transport. | Syringas M et al. | β | 2000 | β |
| The suppressive effects of sucrose and cocaine, but not lithium chloride, are greater in Lewis than in Fischer rats: evidence for the reward comparison hypothesis. | Grigson PS et al. | β | 2000 | β |
| Bicyclo[3.2.1]octanes: synthesis and inhibition of binding at the dopamine and serotonin transporters. | Meltzer PC et al. | β | 1999 | β |
| Cardiovascular responses to cocaine self-administration: acute and chronic tolerance. | Tella SR et al. | β | 1999 | β |
| CART peptide-immunoreactive neurones in the nucleus accumbens in monkeys: ultrastructural analysis, colocalization studies, and synaptic interactions with dopaminergic afferents. | Smith Y et al. | β | 1999 | β |
| Centrally administered galanin blocks morphine place preference in the mouse. | Zachariou V et al. | β | 1999 | β |
| Cerebral MRI on fetuses submitted to repeated cocaine administration during the gestation: an ovine model. | Akoka S et al. | β | 1999 | β |
| CoMFA study of novel phenyl ring-substituted 3alpha-(diphenylmethoxy)tropane analogues at the dopamine transporter. | Newman AH et al. | β | 1999 | β |
| D3 dopamine and kappa opioid receptor alterations in human brain of cocaine-overdose victims. | Mash DC et al. | β | 1999 | β |
| Design, synthesis, and biological evaluation of novel non-piperazine analogues of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines as dopamine transporter inhibitors. | Choi SW et al. | β | 1999 | β |
| Developmental and age-related changes of dopamine transporter, and dopamine D1 and D2 receptors in human basal ganglia. | Meng SZ et al. | β | 1999 | β |
| Differential binding of tropane-based photoaffinity ligands on the dopamine transporter. | Vaughan RA et al. | β | 1999 | β |
| Discovery of novel peptidic dopamine transporter ligands by screening a positional scanning combinatorial hexapeptide library. | Rothman RB et al. | β | 1999 | β |
| Dopaminergic agents for the treatment of cocaine abuse. | Smith MP et al. | β | 1999 | β |
| Doses of GBR12909 that suppress cocaine self-administration in non-human primates substantially occupy dopamine transporters as measured by [11C] WIN35,428 PET scans. | Villemagne VL et al. | β | 1999 | β |
| Drugs of abuse and brain gene expression. | Torres G et al. | β | 1999 | β |
| Effect of the dopaminergic neurotoxin MPTP on cocaine-induced locomotor sensitization. | Itzhak Y et al. | β | 1999 | β |
| Effects of cocaine, nicotine, dizocipline and alcohol on mice locomotor activity: cocaine-alcohol cross-sensitization involves upregulation of striatal dopamine transporter binding sites. | Itzhak Y et al. | β | 1999 | β |
| Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor. | Horger BA et al. | β | 1999 | β |
| Evidence for the sequential formation of two complexes between an uptake inhibitor, GBR 12783 [1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine], and the neuronal transporter of dopamine. | Do-RΓ©go JC et al. | β | 1999 | β |
| Learning versus performance impairments following regional administration of MK-801 into nucleus accumbens and dorsomedial striatum. | Cory-Slechta DA et al. | β | 1999 | β |
| Molecular cloning of the mouse dopamine transporter and pharmacological comparison with the human homologue. | Wu X et al. | β | 1999 | β |
| Pharmacological and environmental determinants of relapse to cocaine-seeking behavior. | Spealman RD et al. | β | 1999 | β |
| Pharmacotherapies for treatment of cocaine abuse: preclinical aspects. | Carroll FI et al. | β | 1999 | β |
| RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine. | Parsons LH et al. | β | 1999 | β |
| Studies of selected phenyltropanes at monoamine transporters. | Kuhar MJ et al. | β | 1999 | β |
| Synthesis of 8-Oxa analogues of norcocaine endowed with interesting cocaine-like activity. | Kozikowski AP et al. | β | 1999 | β |
| (-)-3 beta-Substituted ecgonine methyl esters as inhibitors for cocaine binding and dopamine uptake. | Lieske SF et al. | β | 1998 | β |
| Activating properties of cocaine and cocaethylene in a behavioral preparation of Drosophila melanogaster. | Torres G et al. | β | 1998 | β |
| Butyrylcholinesterase: an enzyme antidote for cocaine intoxication. | Mattes CE et al. | β | 1998 | β |
| Calcium channel antagonist isradipine attenuates cocaine-induced motor activity in rats: correlation with brain monoamine levels. | Mills K et al. | β | 1998 | β |
| Changes in the midbrain-rostral forebrain dopamine circuitry in the cocaine-exposed primate fetal brain. | RΓΈnnekleiv OK et al. | β | 1998 | β |
| Changes in the Midbrain-Rostral Forebrain Dopamine Circuitry in the Cocaine-Exposed Primate Fetal Brain<sup>a</sup>. | RΓΈnnekleiv OK et al. | β | 1998 | β |
| Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter. | Ferrer JV et al. | β | 1998 | β |
| Cocaine and fluoxetine induce the expression of the hVH-5 gene encoding a MAP kinase phosphatase. | Thiriet N et al. | β | 1998 | β |
| Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. | Sora I et al. | β | 1998 | β |
| Cocaine self-administration in dopamine-transporter knockout mice. | Rocha BA et al. | β | 1998 | β |
| Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter. | Sesack SR et al. | β | 1998 | β |
| Dopaminergic genes and substance abuse. | Uhl GR et al. | β | 1998 | β |
| Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT. | Malison RT et al. | β | 1998 | β |
| Ethanol modulates cocaine-induced behavioral change in inbred mice. | Cook MN et al. | β | 1998 | β |
| Food deprivation decreases mRNA and activity of the rat dopamine transporter. | Patterson TA et al. | β | 1998 | β |
| Interactions of buprenorphine and selective dopamine receptor antagonists in the rat nucleus accumbens. | Nantwi KD et al. | β | 1998 | β |
| In vitro selection of RNA molecules that displace cocaine from the membrane-bound nicotinic acetylcholine receptor. | Ulrich H et al. | β | 1998 | β |
| In vivo ibogaine blockade and in vitro PKC action of cocaine. | Onaivi ES et al. | β | 1998 | β |
| In Vivo Ibogaine Blockade and In Vitro PKC Action of Cocaine<sup>a</sup>. | Onaivi ES et al. | β | 1998 | β |
| Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. | Self DW et al. | β | 1998 | β |
| Neural substrates of drug craving and relapse in drug addiction. | Self DW | β | 1998 | β |
| Neuroadaptations involved in amphetamine and cocaine addiction. | White FJ et al. | β | 1998 | β |
| Neurobiology of stress and cocaine addiction. Studies on corticotropin-releasing factor in rats, monkeys, and humans. | Sarnyai Z | β | 1998 | β |
| Opioid reward mechanisms: a key role in drug abuse? | Herz A | β | 1998 | β |
| Oxytocin and addiction: a review. | KovΓ‘cs GL et al. | β | 1998 | β |
| Oxytocin and neuroadaptation to cocaine. | Sarnyai Z | β | 1998 | β |
| Phentermine and fenfluramine. Preclinical studies in animal models of cocaine addiction. | Rothman RB et al. | β | 1998 | β |
| Phentermine and Fenfluramine: Preclinical Studies in Animal Models of Cocaine Addiction. | Rothman RB et al. | β | 1998 | β |
| Recent biochemical studies of the dopamine transporter--a CNS drug target. | Kuhar MJ | β | 1998 | β |
| Repeated administration of cocaine alters dopamine uptake and release in the striatum nucleus accumbens. | Clay LH et al. | β | 1998 | β |
| Research issues related to development of medications for treatment of cocaine addiction. | Klein M | β | 1998 | β |
| Role of endogenous neurotensin in the behavioral and neuroendocrine effects of cocaine. | Betancur C et al. | β | 1998 | β |
| Selective regulation of dopamine transporter binding in the shell of the nucleus accumbens by adrenalectomy and corticosterone-replacement. | Sarnyai Z et al. | β | 1998 | β |
| Serotonin1B receptor stimulation enhances cocaine reinforcement. | Parsons LH et al. | β | 1998 | β |
| Serotonin inhibits synaptic glutamate currents in rat nucleus accumbens neurons via presynaptic 5-HT1B receptors. | Muramatsu M et al. | β | 1998 | β |
| Simple microbore high-performance liquid chromatographic method for the determination of dopamine and cocaine from a single in vivo brain microdialysis sample. | Parsons LH et al. | β | 1998 | β |
| Studies of the biogenic amine transporters. VII. Characterization of a novel cocaine binding site identified with [125I]RTI-55 in membranes prepared from human, monkey and guinea pig caudate. | Rothman RB et al. | β | 1998 | β |
| The region of dopamine transporter encompassing the 3rd transmembrane domain is crucial for function. | Lee SH et al. | β | 1998 | β |
| The role of neuronal nitric oxide synthase in cocaine-induced conditioned place preference. | Itzhak Y et al. | β | 1998 | β |
| The serotonergic system modulates the cocaine-induced expression of the immediate early genes egr-1 and c-fos in rat brain. | Humblot N et al. | β | 1998 | β |
| The Serotonergic System Modulates the Cocaine-Induced Expression of the Immediate Early Genes egr-1 and c-fos in Rat Brain. | Humblot N et al. | β | 1998 | β |
| Unraveling dopamine D3 receptor function in response to psychostimulants using a genetic approach. | Xu M | β | 1998 | β |
| Up- and down-expression of the dopamine transporter by plasmid DNA transfer in the rat brain. | Martres MP et al. | β | 1998 | β |
| 1-[1-2-Benzo[b]thiopheneyl)cyclohexyl]piperidine hydrochloride (BTCP) yields two active primary metabolites in vitro: synthesis, identification from rat liver microsome extracts, and affinity for the neuronal dopamine transporter. | Deleuze-Masquefa C et al. | β | 1997 | β |
| 2-Carbomethoxy-3-aryl-8-oxabicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters. | Meltzer PC et al. | β | 1997 | β |
| 2'-Substitution of cocaine selectively enhances dopamine and norepinephrine transporter binding. | Seale TW et al. | β | 1997 | β |
| 3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile. | Kline RH et al. | β | 1997 | β |
| Cocaine abusers do not show loss of dopamine transporters with age. | Wang GJ et al. | β | 1997 | β |
| Cocaine exposure in fetal rhesus monkey: consequences for dopamine D1- and D2-like receptor binding densities. | Fang Y et al. | β | 1997 | β |
| Cocaine's effects on neuroendocrine systems: clinical and preclinical studies. | Mello NK et al. | β | 1997 | β |
| Cocaine self-administration alters brain NADH dehydrogenase mRNA levels. | Couceyro P et al. | β | 1997 | β |
| Content of dynorphins and kappa-opioid receptors in distinct brain regions of C57BL/6 and DBA/2 mice. | Jamensky NT et al. | β | 1997 | β |
| Differential behavioral responses to cocaethylene of Long-Evans and Sprague-Dawley rats: role of serotonin. | Horowitz JM et al. | β | 1997 | β |
| Direct approach for attenuating cocaine's effects on extracellular dopamine: targeting the dopamine transporter. | Morgan AE et al. | β | 1997 | β |
| Discriminative characteristics of high and low cocaine administration: effect of other psychostimulants. | Schechter MD | β | 1997 | β |
| Dopamine transporter development in postnatal rat striatum: an autoradiographic study with [3H]WIN 35,428. | Coulter CL et al. | β | 1997 | β |
| Effect of dopamine receptor antagonists on cocaine subjective effects: a naturalistic case study. | Ohuoha DC et al. | β | 1997 | β |
| FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects. | Hiroi N et al. | β | 1997 | β |
| Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors. | Matecka D et al. | β | 1997 | β |
| Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]- 1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity. | Dutta AK et al. | β | 1997 | β |
| Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. | Nirenberg MJ et al. | β | 1997 | β |
| Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. | Nirenberg MJ et al. | β | 1997 | β |
| Insights into the neurobiology of impulsive behavior from serotonin receptor knockout mice. | Brunner D et al. | β | 1997 | β |
| Interactions between cocaine and (-)-DS 121: studies with 2-deoxyglucose autoradiography and microdialysis in the rat brain. | Koch S et al. | β | 1997 | β |
| Intravenous cocaine self-administration in mice lacking 5-HT1B receptors. | Rocha BA et al. | β | 1997 | β |
| Kappa2 opioid receptors in limbic areas of the human brain are upregulated by cocaine in fatal overdose victims. | Staley JK et al. | β | 1997 | β |
| Mapping of locomotor behavioral arousal induced by microinjections of dopamine within nucleus accumbens septi of rat forebrain. | Campbell A et al. | β | 1997 | β |
| Maternal cocaine treatment alters dynorphin and enkephalin mRNA expression in brains of fetal rhesus macaques. | Chai L et al. | β | 1997 | β |
| Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. | Rubinstein M et al. | β | 1997 | β |
| New evidence for neurotransmitter influences on brain development. | Levitt P et al. | β | 1997 | β |
| Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter. | Agoston GE et al. | β | 1997 | β |
| PET study of competition between intravenous cocaine and [11C]raclopride at dopamine receptors in human subjects. | Schlaepfer TE et al. | β | 1997 | β |
| Psychostimulant abuse: the case for combined behavioral and pharmacological treatments. | Stitzer ML et al. | β | 1997 | β |
| Quantitation of dopamine transporter mRNA in the rat brain: mapping, effects of "binge" cocaine administration and withdrawal. | Maggos CE et al. | β | 1997 | β |
| Relations between heterogeneity of dopamine transporter binding and function and the behavioral pharmacology of cocaine. | Katz JL et al. | β | 1997 | β |
| Synthesis and ligand binding studies of 4'-iodobenzoyl esters of tropanes and piperidines at the dopamine transporter. | Singh S et al. | β | 1997 | β |
| Synthesis, structure, dopamine transporter affinity, and dopamine uptake inhibition of 6-alkyl-3-benzyl-2-[(methoxycarbonyl)methyl]tropane derivatives. | Lomenzo SA et al. | β | 1997 | β |
| The dopamine transporter: a crucial component regulating dopamine transmission. | Jaber M et al. | β | 1997 | β |
| The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens. | Nirenberg MJ et al. | β | 1997 | β |
| Use of positron emission tomography to study the dynamics of psychostimulant-induced dopamine release. | Mach RH et al. | β | 1997 | β |
| (+/-)-3-[4'-(N,N-dimethylamino)cinnamyl]benzazepine analogs: novel dopamine D1 receptor antagonists. | Shah JH et al. | β | 1996 | β |
| Adaptive increase in D3 dopamine receptors in the brain reward circuits of human cocaine fatalities. | Staley JK et al. | β | 1996 | β |
| A genetic approach to study mechanisms of cocaine action. | Xu M et al. | β | 1996 | β |
| Alcohol plus cocaine: the whole is more than the sum of its parts. | Jatlow P et al. | β | 1996 | β |
| A neurotransmitter transporter encoded by the Drosophila inebriated gene. | Soehnge H et al. | β | 1996 | β |
| A pharmacological study of cocaine activity in planaria. | Palladini G et al. | β | 1996 | β |
| Changes in locomotor activity, core temperature, and heart rate in response to repeated cocaine administration. | Ansah TA et al. | β | 1996 | β |
| Changes in serotonin and norepinephrine uptake sites after chronic cocaine: pre- vs. post-withdrawal effects. | Belej T et al. | β | 1996 | β |
| Chronic cocaine administration increases tyrosine hydroxylase activity in the ventral tegmental area through glutaminergic- and dopaminergic D2-receptor mechanisms. | Masserano JM et al. | β | 1996 | β |
| Chronic cocaine exposure potentiates prolactin and head shake responses to 5-HT2 receptor stimulation in rats. | Baumann MH et al. | β | 1996 | β |
| Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons. | Sklair-Tavron L et al. | β | 1996 | β |
| D2 dopamine receptor gene TaqI A1 and B1 restriction fragment length polymorphisms: enhanced frequencies in psychostimulant-preferring polysubstance abusers. | Persico AM et al. | β | 1996 | β |
| Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909). | Matecka D et al. | β | 1996 | β |
| Differential reinforcing effects of cocaine and GBR-12909: biochemical evidence for divergent neuroadaptive changes in the mesolimbic dopaminergic system. | Tella SR et al. | β | 1996 | β |
| Dopamine D1/D2 antagonist combinations as antagonists of the discriminative stimulus effects of cocaine. | Geter-Douglass B et al. | β | 1996 | β |
| Dopamine transporter immunohistochemistry in median eminence, amygdala, and other areas of the rat brain. | Revay R et al. | β | 1996 | β |
| Drosophila rosA gene, which when mutant causes aberrant photoreceptor oscillation, encodes a novel neurotransmitter transporter homologue. | Burg MG et al. | β | 1996 | β |
| Effect of prenatal cocaine on dopamine receptor-G protein coupling in mesocortical regions of the rabbit brain. | Friedman E et al. | β | 1996 | β |
| Effects of acute and chronic cocaine administration on EEG and behaviour in intact and castrated male and intact and ovariectomized female rats. | van Luijtelaar EL et al. | β | 1996 | β |
| Effects of in utero cocaine exposure on the expression of mRNAS encoding the dopamine transporter and the D1, D2 and D5 dopamine receptor subtypes in fetal rhesus monkey. | Choi WS et al. | β | 1996 | β |
| Haloperidol antagonism of cue-elicited cocaine craving. | Berger SP et al. | β | 1996 | β |
| Highly potent cocaine analogs cause long-lasting increases in locomotor activity. | Fleckenstein AE et al. | β | 1996 | β |
| Immunohistochemical studies of mesolimbic dopaminergic neurons in Fischer 344 and Lewis rats. | Harris HW et al. | β | 1996 | β |
| Individual and combined effects of ethanol and cocaine on intracellular signals and gene expression. | Torres G et al. | β | 1996 | β |
| Influence of cocaine on the JAK-STAT pathway in the mesolimbic dopamine system. | Berhow MT et al. | β | 1996 | β |
| Lack of long-term changes in cocaine and monoamine concentrations in rat CNS following chronic administration of cocaine. | Alburges ME et al. | β | 1996 | β |
| Management of cocaine abuse and dependence. | Mendelson JH et al. | β | 1996 | β |
| Mu opioid receptor mRNA in nucleus accumbens is elevated following dopamine receptor activation. | Azaryan AV et al. | β | 1996 | β |
| Neurochemical changes in cocaine withdrawal. | Kuhar MJ et al. | β | 1996 | β |
| Novel transcription factors are induced by chronic cocaine treatment. | Hope BT | β | 1996 | β |
| Pharmacological characterization of the enhancement of apomorphine-induced gnawing in mice by cocaine. | Tirelli E et al. | β | 1996 | β |
| Postnatal development of the dopamine transporter: a quantitative autoradiographic study. | Coulter CL et al. | β | 1996 | β |
| Prenatal cocaine exposure and postnatal hypoxia independently decrease carotid body dopamine in neonatal rats. | Lipton JW et al. | β | 1996 | β |
| Regulation of ERK (extracellular signal regulated kinase), part of the neurotrophin signal transduction cascade, in the rat mesolimbic dopamine system by chronic exposure to morphine or cocaine. | Berhow MT et al. | β | 1996 | β |
| Structure-activity relationship studies of novel 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-1-(3-phenylpropyl)piperidine analogs: synthesis and biological evaluation at the dopamine and serotonin transporter sites. | Dutta AK et al. | β | 1996 | β |
| Synthesis and dopamine transporter affinity of 2-(methoxycarbonyl)-9-methyl-3-phenyl-9-azabicyclo[3.3.1]nonane derivatives. | Chen Z et al. | β | 1996 | β |
| Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs. | Deutsch HM et al. | β | 1996 | β |
| Synthesis and transporter binding properties of 3 beta-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2 beta-carboxylic acid methyl esters: serotonin transporter selective analogs. | Blough BE et al. | β | 1996 | β |
| Translocation of dopamine and binding of WIN 35,428 measured under identical conditions in cells expressing the cloned human dopamine transporter. | Reith ME et al. | β | 1996 | β |
| Ultrastructural view of central catecholaminergic transmission: immunocytochemical localization of synthesizing enzymes, transporters and receptors. | Pickel VM et al. | β | 1996 | β |
| A cocaine-sensitive active dopamine transport in human lymphocytes. | Faraj BA et al. | β | 1995 | β |
| Acute and chronic amphetamine treatments differently regulate neuropeptide messenger RNA levels and Fos immunoreactivity in rat striatal neurons. | Jaber M et al. | β | 1995 | β |
| A review of the effects of dopaminergic agents on humans, animals, and drug-seeking behavior, and its implications for medication development. Focus on GBR 12909. | Rothman RB et al. | β | 1995 | β |
| Assessment of cocaine-like discriminative stimulus effects of dopamine D3 receptor ligands. | Acri JB et al. | β | 1995 | β |
| Blockade of cocaine-induced conditioned place preference: relevance to cocaine abuse therapeutics. | Calcagnetti DJ et al. | β | 1995 | β |
| DNQX in the nucleus accumbens inhibits cocaine-induced conditioned place preference. | Kaddis FG et al. | β | 1995 | β |
| Effect of medial prefrontal cortex injections of SCH 23390 on intravenous cocaine self-administration under both a fixed and progressive ratio schedule of reinforcement. | McGregor A et al. | β | 1995 | β |
| Effects of cocaine on D3 and D4 receptor expression in the human striatum. | Meador-Woodruff JH et al. | β | 1995 | β |
| Effects of intravenous cocaine on plasma cortisol and prolactin in human cocaine abusers. | Baumann MH et al. | β | 1995 | β |
| Effects of monoamine reuptake inhibitors on cocaine self-administration in rats. | Tella SR | β | 1995 | β |
| Euphorigenic doses of cocaine reduce [123I]beta-CIT SPECT measures of dopamine transporter availability in human cocaine addicts. | Malison RT et al. | β | 1995 | β |
| Evidence for alterations in presynaptic serotonergic function during withdrawal from chronic cocaine in rats. | Baumann MH et al. | β | 1995 | β |
| Fluctuations in nucleus accumbens dopamine during cocaine self-administration behavior: an in vivo electrochemical study. | Kiyatkin EA et al. | β | 1995 | β |
| Genetic polymorphisms at the rat and murine loci coding for dopamine D2-like receptors. | Scott AW et al. | β | 1995 | β |
| Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system. | Berhow MT et al. | β | 1995 | β |
| Localization and quantification of the dopamine transporter: comparison of [3H]WIN 35,428 and [125I]RTI-55. | Coulter CL et al. | β | 1995 | β |
| Mood and anxiety fluctuation in Parkinson's disease associated with levodopa infusion: preliminary findings. | Maricle RA et al. | β | 1995 | β |
| Neurotransmitter transporters: molecular biology, function, and regulation. | Borowsky B et al. | β | 1995 | β |
| Nicotinic cholinergic normalization of amphetamine-induced loss of auditory gating in freely moving rats. | Stevens KE et al. | β | 1995 | β |
| Prenatal cocaine exposure revealed minimal postnatal changes in rat striatal dopamine D2 receptor sites and mRNA levels in the offspring. | Stadlin A et al. | β | 1995 | β |
| Rate of binding of various inhibitors at the dopamine transporter in vivo. | Stathis M et al. | β | 1995 | β |
| Regional brain uptake and pharmacokinetics of [123I]N-omega-fluoroalkyl-2 beta-carboxy-3 beta-(4-iodophenyl)nortropane esters in baboons. | Baldwin RM et al. | β | 1995 | β |
| Repeated cocaine administration reduces 5-HT1A-mediated prolactin secretion in rats. | Baumann MH et al. | β | 1995 | β |
| Serotonergic mechanisms of cocaine effects in humans. | Aronson SC et al. | β | 1995 | β |
| Tegmental pedunculopontine nucleus lesions do not block cocaine reward. | Parker JL et al. | β | 1995 | β |
| Acute administration of alcohol blocks cocaine-induced striatal c-fos immunoreactivity protein in the rat. | Torres G | β | 1994 | β |
| Adenosine A3 receptors regulate serotonin transport via nitric oxide and cGMP. | Miller KJ et al. | β | 1994 | β |
| Blockade of sensitization to the toxic effects of cocaine in mice by nitric oxide synthase inhibitors. | Itzhak Y | β | 1994 | β |
| Can stimulant binding and dopamine transport be differentiated? Studies with GBR 12783 derivatives. | Deutsch HM et al. | β | 1994 | β |
| Catecholamine metabolism and psychiatric or behavioral disorders. | Mallet J et al. | β | 1994 | β |
| Characterization of dopamine transporter and locomotor effects of cocaine, GBR 12909, epidepride, and SCH 23390 in C57BL and DBA mice. | Womer DE et al. | β | 1994 | β |
| Dopamine mechanisms of cocaine addiction. | Kiyatkin EA | β | 1994 | β |
| Effect of 6-hydroxydopamine lesions of the amygdala on intravenous cocaine self-administration under a progressive ratio schedule of reinforcement. | McGregor A et al. | β | 1994 | β |
| Effects of cocaine on sodium dependent dopamine uptake in rat striatal synaptosomes. | Wheeler DD et al. | β | 1994 | β |
| Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice. | Xu M et al. | β | 1994 | β |
| Expression of a high-affinity serotonin transporter in human lymphocytes. | Faraj BA et al. | β | 1994 | β |
| Human placenta: a direct target for cocaine action. | Ganapathy V et al. | β | 1994 | β |
| Induction of c-fos in rat brain by acute cocaine and fenfluramine exposure: a comparison study. | Torres G et al. | β | 1994 | β |
| Neurotransmitter transporters: three important gene families for neuronal function. | Uhl GR et al. | β | 1994 | β |
| Pharmacotherapy of cocaine abuse: preclinical development. | Witkin JM | β | 1994 | β |
| Reduction in dopamine transporter mRNA after cessation of repeated cocaine administration. | Cerruti C et al. | β | 1994 | β |
| Role of oxytocin in the neuroadaptation to drugs of abuse. | Sarnyai Z et al. | β | 1994 | β |
| Second messenger and protein phosphorylation mechanisms underlying possible genetic vulnerability to alcoholism. | Nestler EJ et al. | β | 1994 | β |
| Studies of the biogenic amine transporters. 1. Dopamine reuptake blockers inhibit [3H]mazindol binding to the dopamine transporter by a competitive mechanism: preliminary evidence for different binding domains. | Dersch CM et al. | β | 1994 | β |
| The effect of cocaine abuse on plasma levels of sulfated dopamine and salsolinol in alcoholics. | Faraj BA et al. | β | 1994 | β |
| The effects of acute and chronic cocaine administration on paced responding in intact and gonadectomized male and female Wistar rats. | van Haaren F | β | 1994 | β |
| The selective dopamine uptake inhibitor GBR 12909: its effects on the microstructure of feeding in rats. | van der Hoek GA et al. | β | 1994 | β |
| Allosteric regulation by sodium of the binding of [3H]cocaine and [3H]GBR 12935 to rat and bovine striata. | Eshleman AJ et al. | β | 1993 | β |
| Alterations in the dopaminergic receptor system after chronic administration of cocaine. | Alburges ME et al. | β | 1993 | β |
| Antibody-catalyzed degradation of cocaine. | Landry DW et al. | β | 1993 | β |
| Biosynthesis of dopamine and serotonin in the rat brain after repeated cocaine injections: a microdissection mapping study. | Baumann MH et al. | β | 1993 | β |
| Canine cataplexy is preferentially controlled by adrenergic mechanisms: evidence using monoamine selective uptake inhibitors and release enhancers. | Mignot E et al. | β | 1993 | β |
| Clearance of exogenous dopamine in rat dorsal striatum and nucleus accumbens: role of metabolism and effects of locally applied uptake inhibitors. | Cass WA et al. | β | 1993 | β |
| Cocaine binding sites in fetal rat brain: implications for prenatal cocaine action. | Meyer JS et al. | β | 1993 | β |
| Cocaine-induced elevation of plasma corticosterone is mediated by different neurotransmitter systems in rats. | Sarnyai Z et al. | β | 1993 | β |
| Cocaine-related movement disorders. | Cardoso FE et al. | β | 1993 | β |
| Concurrent cocaine-ethanol ingestion in humans: pharmacology, physiology, behavior, and the role of cocaethylene. | McCance-Katz EF et al. | β | 1993 | β |
| Correlation of acute cocaine-induced changes in local cerebral blood flow with subjective effects. | Pearlson GD et al. | β | 1993 | β |
| Drug addiction: a model for the molecular basis of neural plasticity. | Nestler EJ et al. | β | 1993 | β |
| Effects of acute and chronic cocaine on the activity of tuberoinfundibular dopamine neurons in the rat. | Baumann MH et al. | β | 1993 | β |
| Effects of cocaine on dopamine receptor gene expression: a study in the postmortem human brain. | Meador-Woodruff JH et al. | β | 1993 | β |
| Effects of the dopamine release inhibitor, CGS 10746B, on the locomotor stimulant and discriminative stimulus effects of cocaine and methamphetamine. | French D et al. | β | 1993 | β |
| Elevated concentrations of dopamine sulfate in plasma of cocaine abusers. | Faraj BA et al. | β | 1993 | β |
| GBR 12909 fails to antagonize cocaine-induced elevation of dopamine in striatal slices. | Gifford AN et al. | β | 1993 | β |
| Parameters of self-administration of cocaine in rats under a progressive-ratio schedule. | Depoortere RY et al. | β | 1993 | β |
| Positron emission tomographic imaging of the dopamine transporter with 11C-WIN 35,428 reveals marked declines in mild Parkinson's disease. | Frost JJ et al. | β | 1993 | β |
| Potent cocaine analogs inhibit [3H]dopamine uptake in rat mesencephalic cells in primary cultures: pharmacological selectivity of embryonic cocaine sites. | Brouard A et al. | β | 1993 | β |
| Prenatal cocaine administration stimulates fetal brain tyrosine hydroxylase activity. | Meyer JS et al. | β | 1993 | β |
| Self-administration of GBR 12909 on a fixed ratio and progressive ratio schedule in rats. | Roberts DC | β | 1993 | β |
| SPECT imaging of dopamine and serotonin transporters with [123I]beta-CIT: pharmacological characterization of brain uptake in nonhuman primates. | Laruelle M et al. | β | 1993 | β |
| Studies of the biogenic amine transporters. II. A brief study on the use of [3H]DA-uptake-inhibition to transporter-binding-inhibition ratios for the in vitro evaluation of putative cocaine antagonists. | Rothman RB et al. | β | 1993 | β |
| Substance abuse vulnerability and D2 receptor genes. | Uhl G et al. | β | 1993 | β |
| The effects of SCH 23390 and raclopride on cocaine-induced analepsis and EEG arousal in rabbits. | Yoshida K et al. | β | 1993 | β |
| Advances in sodium-ion coupled biogenic amine transporters. | Graham D et al. | β | 1992 | β |
| Cocaine-induced behavioral sensitization and D1 dopamine receptor function in rat nucleus accumbens and striatum. | Mayfield RD et al. | β | 1992 | β |
| Differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration. | Cass WA et al. | β | 1992 | β |
| Effect of cocaine use on the fetus. | Volpe JJ | β | 1992 | β |
| Effects of cocaine alone and in combination with prazosin or ondansetron on multiple fixed-interval fixed-ratio performance in pigeons. | van Haaren F | β | 1992 | β |
| High potency cocaine analogs: neurochemical, imaging, and behavioral studies. | Boja JW et al. | β | 1992 | β |
| Microheterogeneity of dopamine transporters in rat striatum and nucleus accumbens. | Lew R et al. | β | 1992 | β |
| Molecular pharmacology of cocaine: a dopamine hypothesis and its implications. | Kuhar MJ | β | 1992 | β |
| Neurotransmitter transporters (plus): a promising new gene family. | Uhl GR | β | 1992 | β |
| Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine. | Hope B et al. | β | 1992 | β |
| Temperature-dependent effects of maternal separation on growth, activity, and amphetamine sensitivity in the rat. | Zimmerberg B et al. | β | 1992 | β |
| Tuberculosis: commentary on a reemergent killer. | Bloom BR et al. | β | 1992 | β |