Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology.
paper
Cited
Public
Unavailable
- Authors
- Pritchett, D B; Sontheimer, H; Shivers, B D; Ymer, S; Kettenmann, H; Schofield, P R; Seeburg, P H
- Year
- 1989
- Journal
- Nature
- PMID
- 2538761
- DOI
- 10.1038/338582a0
Neurotransmission effected by GABA (gamma-aminobutyric acid) is predominantly mediated by a gated chloride channel intrinsic to the GABAA receptor. This heterooligomeric receptor exists in most inhibitory synapses in the vertebrate central nervous system (CNS) and can be regulated by clinically important compounds such as benzodiazepines and barbiturates. The primary structures of GABAA receptor alpha- and beta-subunits have been deduced from cloned complementary DNAs. Co-expression of these subunits in heterologous systems generates receptors which display much of the pharmacology of their neural counterparts, including potentiation by barbiturates. Conspicuously, however, they lack binding sites for, and consistent electrophysiological responses to, benzodiazepines. We now report the isolation of a cloned cDNA encoding a new GABAA receptor subunit, termed gamma 2, which shares approximately 40% sequence identity with alpha- and beta-subunits and whose messenger RNA is prominently localized in neuronal subpopulations throughout the CNS. Importantly, coexpression of the gamma 2 subunit with alpha 1 and beta 1 subunits produces GABAA receptors displaying high-affinity binding for central benzodiazepine receptor ligands.
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| Plastic neuronal changes in GABA(A) receptor gene expression induced by progesterone metabolites: in vitro molecular and functional studies. | Biggio F et al. | β | 2006 | β |
| Pretty subunits all in a row: using concatenated subunit constructs to force the expression of receptors with defined subunit stoichiometry and spatial arrangement. | White MM | β | 2006 | β |
| Selective changes in thalamic and cortical GABAA receptor subunits in a model of acquired absence epilepsy in the rat. | Li H et al. | β | 2006 | β |
| Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons. | Prenosil GA et al. | β | 2006 | β |
| Subunit selectivity of topiramate modulation of heteromeric GABA(A) receptors. | Simeone TA et al. | β | 2006 | β |
| Agonistic effects of the beta-carboline DMCM revealed in GABA(A) receptor gamma 2 subunit F77I point-mutated mice. | LeppΓ€ E et al. | β | 2005 | β |
| Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear. | Sonner JM et al. | β | 2005 | β |
| A new pyridazine series of GABAA alpha5 ligands. | van Niel MB et al. | β | 2005 | β |
| An in situ hybridization and immunofluorescence study of GABA(A) and GABA(B) receptors in the vestibular nuclei of the intact and unilaterally labyrinthectomized rat. | Eleore L et al. | β | 2005 | β |
| Benzodiazepine involvement in LTP of the GABA-ergic IPSC in rat hippocampal CA1 neurons. | Xu JY et al. | β | 2005 | β |
| Consequences of the evolution of the GABA(A) receptor gene family. | Darlison MG et al. | β | 2005 | β |
| Dependence on zolpidem: two case reports of detoxification with flumazenil infusion. | Quaglio G et al. | β | 2005 | β |
| Determinants of amentoflavone interaction at the GABA(A) receptor. | Hansen RS et al. | β | 2005 | β |
| Developmental changes in expression of GABAA receptor-channels in rat intrinsic cardiac ganglion neurones. | Fischer H et al. | β | 2005 | β |
| Development of subtype selective GABAA modulators. | Dawson GR et al. | β | 2005 | β |
| Differential expression of gamma-aminobutyric acid--a receptor subunits in rat dorsal and ventral hippocampus. | Sotiriou E et al. | β | 2005 | β |
| Differential GABA(A) subunit expression following status epilepticus in seizure-prone and seizure-resistant rats: a putative mechanism for refractory drug response. | Gilby KL et al. | β | 2005 | β |
| Differential protein mobility of the gamma-aminobutyric acid, type A, receptor alpha and beta subunit channel-lining segments. | Horenstein J et al. | β | 2005 | β |
| Formation of GABAergic synapses in the cerebellum. | Takayama C | β | 2005 | β |
| GABAA receptor gamma 2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines. | Chandra D et al. | β | 2005 | β |
| Glycinergic and GABAergic synaptic transmission are differentially affected by gephyrin in spinal neurons. | van Zundert B et al. | β | 2005 | β |
| Rearranging receptors. | Brooks-Kayal AR | β | 2005 | β |
| Rodent pharmacokinetics and receptor occupancy of the GABAA receptor subtype selective benzodiazepine site ligand L-838417. | Scott-Stevens P et al. | β | 2005 | β |
| The gamma-subunit governs the susceptibility of recombinant gamma-aminobutyric acid type A receptors to block by the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6, 2N). | Zarnowska ED et al. | β | 2005 | β |
| 3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1. | Carling RW et al. | β | 2004 | β |
| A GABAA receptor mutation linked to human epilepsy (gamma2R43Q) impairs cell surface expression of alphabetagamma receptors. | Sancar F et al. | β | 2004 | β |
| Alpha 5 subunit-containing GABAA receptors affect the dynamic range of mouse hippocampal kainate-induced gamma frequency oscillations in vitro. | Towers SK et al. | β | 2004 | β |
| Anxioselective anxiolytics: can less be more? | Basile AS et al. | β | 2004 | β |
| Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians. | Foley PF et al. | β | 2004 | β |
| Autoradiographic imaging of altered synaptic alphabetagamma2 and extrasynaptic alphabeta GABAA receptors in a genetic mouse model of anxiety. | Sinkkonen ST et al. | β | 2004 | β |
| Clustering of extrasynaptic GABA(A) receptors modulates tonic inhibition in cultured hippocampal neurons. | Petrini EM et al. | β | 2004 | β |
| Differential actions of diazepam and zolpidem in basolateral and central amygdala nuclei. | Kang-Park MH et al. | β | 2004 | β |
| Electrophysiological properties of mouse horizontal cell GABAA receptors. | Feigenspan A et al. | β | 2004 | β |
| Expression of functional receptors by the human gamma-aminobutyric acid A gamma 2 subunit. | MartΓnez-Torres A et al. | β | 2004 | β |
| GABA(A)/central benzodiazepine receptor and peripheral benzodiazepine receptor ligands as inducers of phenobarbital-inducible CYP2B and CYP3A. | Roberge C et al. | β | 2004 | β |
| GABAergic signaling in the developing cerebellum. | Takayama C et al. | β | 2004 | β |
| GABA pharmacology--what prospects for the future? | Iversen L | β | 2004 | β |
| Hypersensitivity to pentylenetetrazol-induced convulsion in mice lacking the PLC-related inactive protein-1. | Yamaguchi T et al. | β | 2004 | β |
| Isoflurane facilitates hiccup-like reflex through gamma aminobutyric acid (GABA)A- and suppresses through GABAB-receptors in pentobarbital-anesthetized cats. | Oshima T et al. | β | 2004 | β |
| Modelling extracellular domains of GABA-A receptors: subtypes 1, 2, 3, and 5. | Chou KC | β | 2004 | β |
| Modulation of GABA(A) receptor gene expression by allopregnanolone and ethanol. | Follesa P et al. | β | 2004 | β |
| Mutation of glutamate 155 of the GABAA receptor beta2 subunit produces a spontaneously open channel: a trigger for channel activation. | Newell JG et al. | β | 2004 | β |
| On the benzodiazepine binding pocket in GABAA receptors. | Berezhnoy D et al. | β | 2004 | β |
| Palmitoylation regulates the clustering and cell surface stability of GABAA receptors. | Rathenberg J et al. | β | 2004 | β |
| Pentobarbital differentially modulates alpha1beta3delta and alpha1beta3gamma2L GABAA receptor currents. | Feng HJ et al. | β | 2004 | β |
| Proton modulation of alpha 1 beta 3 delta GABAA receptor channel gating and desensitization. | Feng HJ et al. | β | 2004 | β |
| Selective neuroinhibitory effects of taurine in slices of rat main olfactory bulb. | Belluzzi O et al. | β | 2004 | β |
| Sensitivity of thalamic GABAergic currents to clonazepam does not differ between control and genetic absence epilepsy rats. | Badiu CI | β | 2004 | β |
| 5-HT1A receptor knockout mouse as a genetic model of anxiety. | Toth M | β | 2003 | β |
| Changes in GABA(A) receptor gene expression associated with selective alterations in receptor function and pharmacology after ethanol withdrawal. | Sanna E et al. | β | 2003 | β |
| Constitutive GABAA receptor endocytosis is dynamin-mediated and dependent on a dileucine AP2 adaptin-binding motif within the beta 2 subunit of the receptor. | Herring D et al. | β | 2003 | β |
| Deletion of the alpha1 or beta2 subunit of GABAA receptors reduces actions of alcohol and other drugs. | Blednov YA et al. | β | 2003 | β |
| Diazepam as a treatment for metronidazole toxicosis in dogs: a retrospective study of 21 cases. | Evans J et al. | β | 2003 | β |
| Dose-dependent EEG effects of zolpidem provide evidence for GABA(A) receptor subtype selectivity in vivo. | Visser SA et al. | β | 2003 | β |
| Extrasynaptic GABA(A) channels activated by THIP are modulated by diazepam in CA1 pyramidal neurons in the rat brain hippocampal slice. | Lindquist CE et al. | β | 2003 | β |
| GABA(Abeta2-3) immunoreactive cells in the developing chick retina. | Barros PH et al. | β | 2003 | β |
| Hemoglobin metabolites mimic benzodiazepines and are possible mediators of hepatic encephalopathy. | Ruscito BJ et al. | β | 2003 | β |
| Methylmercury differentially affects GABA(A) receptor-mediated spontaneous IPSCs in Purkinje and granule cells of rat cerebellar slices. | Yuan Y et al. | β | 2003 | β |
| Microarray analysis of murine palatogenesis: temporal expression of genes during normal palate development. | Brown NL et al. | β | 2003 | β |
| Molecular characterization of new polymorphisms at the beta2, alpha1, gamma2 GABA(A) receptor subunit genes associated to a rat nonpreferring ethanol phenotype. | Congeddu E et al. | β | 2003 | β |
| Molecular mechanisms of tolerance to and withdrawal of GABA(A) receptor modulators. | Biggio G et al. | β | 2003 | β |
| Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. | Huen MS et al. | β | 2003 | β |
| Neuroadaptive processes in GABAergic and glutamatergic systems in benzodiazepine dependence. | Allison C et al. | β | 2003 | β |
| Quantitative in vivo measurement of central benzodiazepine receptors in the brain of cats by use of positron-emission tomography and [11C]flumazenil. | Shimada Y et al. | β | 2003 | β |
| Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug. | Sinkkonen ST et al. | β | 2003 | β |
| Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioral stress responses. | Hsu FC et al. | β | 2003 | β |
| Activation of the midbrain periaqueductal gray induces airway smooth muscle relaxation. | Haxhiu MA et al. | β | 2002 | β |
| Alprazolam, a benzodiazepine, does not modify the ACTH and cortisol response to hCRH and AVP, but blunts the cortisol response to ACTH in humans. | Grottoli S et al. | β | 2002 | β |
| Altered receptor subtypes in the forebrain of GABA(A) receptor delta subunit-deficient mice: recruitment of gamma 2 subunits. | Korpi ER et al. | β | 2002 | β |
| Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. | Hui KM et al. | β | 2002 | β |
| Changes in GABAA receptor gamma 2 subunit gene expression induced by long-term administration of oral contraceptives in rats. | Follesa P et al. | β | 2002 | β |
| Comparison of the effects of zaleplon, zolpidem, and triazolam at various GABA(A) receptor subtypes. | Sanna E et al. | β | 2002 | β |
| Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors. | Scheller M et al. | β | 2002 | β |
| Differential effects of prenatal cocaine exposure on selected subunit mRNAs of the GABA(A) receptor in rabbit anterior cingulate cortex. | Shumsky JS et al. | β | 2002 | β |
| Drug interactions at GABA(A) receptors. | Korpi ER et al. | β | 2002 | β |
| Forced subunit assembly in alpha1beta2gamma2 GABAA receptors. Insight into the absolute arrangement. | Baumann SW et al. | β | 2002 | β |
| Functional characterization of GABA(A) receptors in neonatal hypothalamic brain slice. | Huang RQ et al. | β | 2002 | β |
| GABA(A) receptor changes in delta subunit-deficient mice: altered expression of alpha4 and gamma2 subunits in the forebrain. | Peng Z et al. | β | 2002 | β |
| GABA(A) receptor heterogeneity in histaminergic neurons. | Sergeeva OA et al. | β | 2002 | β |
| GABA(A) receptor sites in the developing human foetus. | Andersen DL et al. | β | 2002 | β |
| Ligand-gated ion channels in the enteric nervous system. | Galligan JJ | β | 2002 | β |
| Mechanisms of GABAA receptor assembly and trafficking: implications for the modulation of inhibitory neurotransmission. | Kittler JT et al. | β | 2002 | β |
| Neuroactive steroid mechanisms and GABA type A receptor subunit assembly in hypothalamic and extrahypothalamic regions. | Canonaco M et al. | β | 2002 | β |
| PET imaging of ischemic neuronal death in the hippocampus of living monkeys. | Zhao L et al. | β | 2002 | β |
| Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. | Brown N et al. | β | 2002 | β |
| Prenatal diazepam exposure functionally alters the GABA(A) receptor that modulates [3H]noradrenaline release from rat hippocampal synaptosomes. | Martire M et al. | β | 2002 | β |
| Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors. | Brandon NJ et al. | β | 2002 | β |
| Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors. | Nymann-Andersen J et al. | β | 2002 | β |
| The heterogeneity of central benzodiazepine receptor subtypes in the human hippocampal formation, frontal cortex and cerebellum using [3H]flumazenil and zolpidem. | McLeod M et al. | β | 2002 | β |
| The relative amount of cRNA coding for gamma2 subunits affects stimulation by benzodiazepines in GABA(A) receptors expressed in Xenopus oocytes. | Boileau AJ et al. | β | 2002 | β |
| Two different mechanisms of disinhibition produced by GABAA receptor mutations linked to epilepsy in humans. | Bianchi MT et al. | β | 2002 | β |
| Unique assignment of inter-subunit association in GABA(A) alpha 1 beta 3 gamma 2 receptors determined by molecular modeling. | Trudell J | β | 2002 | β |
| [3H]Flunitrazepam binding to recombinant alpha1beta2gamma2S GABAA receptors stably expressed in HEK 293 cells. | PericiΔ D et al. | β | 2001 | β |
| alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential. | Adkins CE et al. | β | 2001 | β |
| Altered gabaa receptor subunit and splice variant expression in rats treated with chronic intermittent ethanol. | Petrie J et al. | β | 2001 | β |
| Characterization of gamma-aminobutyrate type A receptors with atypical coupling between agonist and convulsant binding sites in discrete brain regions. | Sinkkonen ST et al. | β | 2001 | β |
| Common effects of chronically administered antipanic drugs on brainstem GABA(A) receptor subunit gene expression. | Tanay VM et al. | β | 2001 | β |
| Constructing inhibitory synapses. | Moss SJ et al. | β | 2001 | β |
| Differential cross talk of ROD compounds with the benzodiazepine binding site. | Sigel E et al. | β | 2001 | β |
| Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux. | Smith AJ et al. | β | 2001 | β |
| Effects of gamma-HCH and delta-HCH on human recombinant GABA(A) receptors: dependence on GABA(A) receptor subunit combination. | Maskell PD et al. | β | 2001 | β |
| Evaluation of native GABA(A) receptors containing an alpha 5 subunit. | Li M et al. | β | 2001 | β |
| Evidence for the formation of functionally distinct alphabetagammaepsilon GABA(A) receptors. | Davies PA et al. | β | 2001 | β |
| Expression of GABA(A) receptor subunits in the rat central nucleus of the inferior colliculus. | Shiraishi S et al. | β | 2001 | β |
| Functional analysis of GABA(A) receptors in nucleus tractus solitarius neurons from neonatal rats. | Huang RQ et al. | β | 2001 | β |
| Functional pharmacology of GABA(A) receptors containing the chicken brain gamma 4 subunit. | Forster IC et al. | β | 2001 | β |
| GABAA-receptor plasticity during long-term exposure to and withdrawal from progesterone. | Biggio G et al. | β | 2001 | β |
| gamma-Aminobutyric acid(A) receptor subunit expression predicts functional changes in hippocampal dentate granule cells during postnatal development. | Brooks-Kayal AR et al. | β | 2001 | β |
| Gamma-aminobutyric acid receptor (GABA(A)) subunits in rat nucleus tractus solitarii (NTS) revealed by polymerase chain reaction (PCR) and immunohistochemistry. | Saha S et al. | β | 2001 | β |
| Heterogeneity of hippocampal GABA(A) receptors: regulation by corticosterone. | Orchinik M et al. | β | 2001 | β |
| Intrahippocampal infusion of antisense oligodeoxynucleotide to the GABA(A) receptor gamma2 subunit enhances neuropeptide Y gene expression. | Mikkelsen JD et al. | β | 2001 | β |
| Lateral mobility and anchoring of recombinant GABAA receptors depend on subunit composition. | Peran M et al. | β | 2001 | β |
| Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics. | Krasowski MD et al. | β | 2001 | β |
| Nitric oxide directly activates GABA(A) receptor function through a cGMP/protein kinase-independent pathway in frog pituitary melanotrophs. | Castel H et al. | β | 2001 | β |
| Positive allosteric modulation by ultraviolet irradiation on GABA(A), but not GABA(C), receptors expressed in Xenopus oocytes. | Chang Y et al. | β | 2001 | β |
| Postnatal maturation of human GABAA receptors measured with positron emission tomography. | Chugani DC et al. | β | 2001 | β |
| Role of allopregnanolone in regulation of GABA(A) receptor plasticity during long-term exposure to and withdrawal from progesterone. | Follesa P et al. | β | 2001 | β |
| Sensitivity of synaptic GABA(A) receptors to allosteric modulators in hippocampal oriens-alveus interneurons. | Patenaude C et al. | β | 2001 | β |
| Subunit arrangement of gamma-aminobutyric acid type A receptors. | Baumann SW et al. | β | 2001 | β |
| The 5-HT(1A) receptor knockout mouse and anxiety. | Olivier B et al. | β | 2001 | β |
| Additivities of compounds that increase the numbers of high affinity [3H]muscimol binding sites by different amounts define more than 9 GABA(A) receptor complexes in rat forebrain: implications for schizophrenia and clozapine research. | Squires RF et al. | β | 2000 | β |
| A novel positive allosteric modulator of the GABA(A) receptor: the action of (+)-ROD188. | Thomet U et al. | β | 2000 | β |
| Arg-274 and Leu-277 of the gamma-aminobutyric acid type A receptor alpha 2 subunit define agonist efficacy and potency. | O'Shea SM et al. | β | 2000 | β |
| A single amino acid residue on the alpha(5) subunit (Ile215) is essential for ligand selectivity at alpha(5)beta(3)gamma(2) gamma-aminobutyric acid(A) receptors. | Strakhova MI et al. | β | 2000 | β |
| Association analysis of the GABA(A) receptor subunit genes cluster on 5q33-34 and alcohol dependence in a Japanese population. | Loh EW et al. | β | 2000 | β |
| Behavioural changes produced by transgenic overexpression of gamma2L and gamma2S subunits of the GABAA receptor. | Wick MJ et al. | β | 2000 | β |
| Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms. | Walters RJ et al. | β | 2000 | β |
| Benzodiazepines induce a conformational change in the region of the gamma-aminobutyric acid type A receptor alpha(1)-subunit M3 membrane-spanning segment. | Williams DB et al. | β | 2000 | β |
| Benzodiazepines in perspective (II): The GABAA-Benzodiazepine Receptor Ligands. | Vermeulen PJ et al. | β | 2000 | β |
| Brainstem viscerotopic organization of afferents and efferents involved in the control of swallowing. | Broussard DL et al. | β | 2000 | β |
| Characterization of benzodiazepine receptors in the cerebellum. | Lameh J et al. | β | 2000 | β |
| Chlordiazepoxide-induced spatial learning deficits: dose-dependent differences following prenatal malnutrition. | Tonkiss J et al. | β | 2000 | β |
| Chronic blockade of N-methyl-D-aspartate receptors alters gamma-aminobutyric acid type A receptor peptide expression and function in the rat. | Matthews DB et al. | β | 2000 | β |
| Chronic ethanol consumption alters recovery of spontaneously active medial septal/diagonal band of broca neurons from GABA-microiontophoresis. | Matthews DB et al. | β | 2000 | β |
| Cocaine abusers show a blunted response to alcohol intoxication in limbic brain regions. | Volkow ND et al. | β | 2000 | β |
| Coupling between agonist and chloride ionophore sites of the GABA(A) receptor: agonist/antagonist efficacy of 4-PIOL. | Rabe H et al. | β | 2000 | β |
| Determinants of recognition of ligands binding to benzodiazepine receptor/GABA(A) receptors initiating sedation. | Harris DL et al. | β | 2000 | β |
| Developmental switch in the expression of GABA(A) receptor subunits alpha(1) and alpha(2) in the hypothalamus and limbic system of the rat. | Davis AM et al. | β | 2000 | β |
| Development and assessment of a 3D pharmacophore for ligand recognition of BDZR/GABAA receptors initiating the anxiolytic response. | Harris DL et al. | β | 2000 | β |
| Development of a 3D pharmacophore for nonspecific ligand recognition of alpha1, alpha2, alpha3, alpha5, and alpha6 containing GABA(A)/benzodiazepine receptors. | Filizola M et al. | β | 2000 | β |
| Differential modulatory actions of the volatile convulsant flurothyl and its anesthetic isomer at inhibitory ligand-gated ion channels. | Krasowski MD | β | 2000 | β |
| Dopamine-antagonistic, anticholinergic, and GABAergic effects on declarative and procedural memory functions. | Rammsayer TH et al. | β | 2000 | β |
| Early expression of GABA(A) receptor delta subunit in the neonatal rat hippocampus. | Didelon F et al. | β | 2000 | β |
| Evidence for coassembly of mutant GABAC rho1 with GABAA gamma2S, glycine alpha1 and glycine alpha2 receptor subunits in vitro. | Pan ZH et al. | β | 2000 | β |
| GABA(A) receptors on calbindin-immunoreactive myenteric neurons of guinea pig intestine. | Zhou X et al. | β | 2000 | β |
| Heterogeneity of GABA(A) receptor-mediated responses in the human IMR-32 neuroblastoma cell line. | Sapp DW et al. | β | 2000 | β |
| Modulation of GABAergic synaptic transmission by the non-benzodiazepine anxiolytic etifoxine. | Schlichter R et al. | β | 2000 | β |
| Nitrous oxide and xenon increase the efficacy of GABA at recombinant mammalian GABA(A) receptors. | Hapfelmeier G et al. | β | 2000 | β |
| Olanzapine increases allopregnanolone in the rat cerebral cortex. | Marx CE et al. | β | 2000 | β |
| Pharmacology of GABA(A) receptors of retinal dopaminergic neurons. | Feigenspan A et al. | β | 2000 | β |
| Prenatally protein-malnourished rats are less sensitive to the amnestic effects of medial septal infusions of chlordiazepoxide. | Tonkiss J et al. | β | 2000 | β |
| Protracted postnatal development of inhibitory synaptic transmission in rat hippocampal area CA1 neurons. | Cohen AS et al. | β | 2000 | β |
| Redox modulation of recombinant human GABA(A) receptors. | Pan ZH et al. | β | 2000 | β |
| Regional variations in the effects of chronic ethanol administration on GABA(A) receptor expression: potential mechanisms. | Grobin AC et al. | β | 2000 | β |
| Regulation of GABAA receptor by protein tyrosine kinases in frog pituitary melanotrophs. | Castel H et al. | β | 2000 | β |
| Regulation of the GABA(A) receptor by nitric oxide in frog pituitary melanotrophs. | Castel H et al. | β | 2000 | β |
| Role of the GABA(A)beta2, GABA(A)alpha6, GABA(A)alpha1 and GABA(A)gamma2 receptor subunit genes cluster in drug responses and the development of alcohol dependence. | Loh EW et al. | β | 2000 | β |
| Stable GABA(A) receptor intermediates in SF-9 cells expressing alpha1, beta2 and gamma2 subunits. | Elster L et al. | β | 2000 | β |
| Targeting brain GABAA receptors with antisense oligonucleotides: implications for epilepsy. | Karle J et al. | β | 2000 | β |
| The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations. | Krasowski MD et al. | β | 2000 | β |
| The influence of an endogenous beta3 subunit on recombinant GABA(A) receptor assembly and pharmacology in WSS-1 cells and transiently transfected HEK293 cells. | Davies PA et al. | β | 2000 | β |
| Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol. | Ueno S et al. | β | 2000 | β |
| Two conserved arginines in the extracellular N-terminal domain of the GABA(A) receptor alpha(5) subunit are crucial for receptor function. | Hartvig L et al. | β | 2000 | β |
| Unraveling the identity of benzodiazepine binding sites in rat hipppocampus and olfactory bulb. | Lameh J et al. | β | 2000 | β |
| Abecarnil enhances recovery from diazepam tolerance. | Zanotti A et al. | β | 1999 | β |
| Actions of fluorinated alkanols on GABA(A) receptors: relevance to theories of narcosis. | Ueno S et al. | β | 1999 | β |
| Activation of rat locus coeruleus neuron GABA(A) receptors by propofol and its potentiation by pentobarbital or alphaxalone. | Chen CL et al. | β | 1999 | β |
| Acute cellular alterations in the hippocampus after status epilepticus. | Macdonald RL et al. | β | 1999 | β |
| Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine. | Chang Y et al. | β | 1999 | β |
| Alterations of GABAA receptor subunit mRNA levels associated with increases in punished responding induced by acute alprazolam administration: an in situ hybridization study. | Liu M et al. | β | 1999 | β |
| Antagonistic action of pitrazepin on human and rat GABA(A) receptors. | Demuro A et al. | β | 1999 | β |
| Bicuculline-resistant, Cl- dependent GABA response in the rat spinal dorsal horn. | Park JS et al. | β | 1999 | β |
| Central benzodiazepine involvement in clonidine cardiovascular actions. | Castro JL et al. | β | 1999 | β |
| Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor. | GaliΓ¨gue S et al. | β | 1999 | β |
| Decreased GABA enhancement of benzodiazepine binding after a single dose of diazepam. | Holt RA et al. | β | 1999 | β |
| Differential effects of zinc on native GABA(A) receptor function in rat hippocampus and cerebellum. | Schmid G et al. | β | 1999 | β |
| Dual mode of stimulation by the beta-carboline ZK 91085 of recombinant GABA(A) receptor currents: molecular determinants affecting its action. | Thomet U et al. | β | 1999 | β |
| Effects of isoflurane and hexafluorodiethyl ether on human recombinant GABA(A) receptors expressed in Sf9 cells. | Yamashita M et al. | β | 1999 | β |
| Expression of gamma-aminobutyric acid(A) receptor subunits in the vestibular system. | Rezaee A et al. | β | 1999 | β |
| Functional GABAA receptor heterogeneity of acutely dissociated hippocampal CA1 pyramidal cells. | Tietz EI et al. | β | 1999 | β |
| GABA(A) receptors expressed in undifferentiated human teratocarcinoma NT2 cells differ from those expressed by differentiated NT2-N cells. | Neelands TR et al. | β | 1999 | β |
| General anaesthetic actions on ligand-gated ion channels. | Krasowski MD et al. | β | 1999 | β |
| Human neuronal gamma-aminobutyric acid(A) receptors: coordinated subunit mRNA expression and functional correlates in individual dentate granule cells. | Brooks-Kayal AR et al. | β | 1999 | β |
| Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors. | Neelands TR et al. | β | 1999 | β |
| Increased abundance of GABAA receptor subunit mRNAs in the brain of Long-Evans Cinnamon rats, an animal model of Wilson's disease. | Follesa P et al. | β | 1999 | β |
| In situ hybridization histochemistry as a method to assess GABA(A) receptor subunit mRNA expression following chronic alprazolam administration. | Fahey JM et al. | β | 1999 | β |
| Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient mice. | Kneussel M et al. | β | 1999 | β |
| Modulation of neuronal and recombinant GABAA receptors by redox reagents. | Amato A et al. | β | 1999 | β |
| Molecular and functional diversity of the expanding GABA-A receptor gene family. | Whiting PJ et al. | β | 1999 | β |
| New directions in anxiolytic drug research. | Scott MK et al. | β | 1999 | β |
| New insights into the mechanism of action of hypnotics. | Doble A | β | 1999 | β |
| Physiological modulation of GABA(A) receptor plasticity by progesterone metabolites. | Concas A et al. | β | 1999 | β |
| Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality. | Jacobsen EJ et al. | β | 1999 | β |
| Postnatal development of GABAA receptor beta1, beta2/3, and gamma2 immunoreactivity in the rat retina. | Koulen P | β | 1999 | β |
| Receptor system response kinetics reveal functional subtypes of native murine and recombinant human GABAA receptors. | McClellan AM et al. | β | 1999 | β |
| Response kinetics and pharmacological properties of heteromeric receptors formed by coassembly of GABA rho- and gamma 2-subunits. | Qian H et al. | β | 1999 | β |
| Stoichiometry of a ligand-gated ion channel determined by fluorescence energy transfer. | Farrar SJ et al. | β | 1999 | β |
| Subunit dependent modulation of GABAA receptor function by neuroactive steroids. | Maitra R et al. | β | 1999 | β |
| Subunit mutations affect ethanol actions on GABA(A) receptors expressed in Xenopus oocytes. | Ueno S et al. | β | 1999 | β |
| Synthesis and benzodiazepine receptor (omega receptor) affinities of 3-substituted derivatives of pyrrolo[2,3-c]pyridine-5-carboxylate, a novel class of omega1 selective ligands. | Doisy X et al. | β | 1999 | β |
| Synthesis and evaluation of [123I]labelled analogues of the partial inverse agonist Ro 15-4513 for the study of diazepam-insensitive benzodiazepine receptors. | Katsifis A et al. | β | 1999 | β |
| Temporal and regional regulation of alpha1, beta2 and beta3, but not alpha2, alpha4, alpha5, alpha6, beta1 or gamma2 GABA(A) receptor subunit messenger RNAs following one-week oral flurazepam administration. | Tietz EI et al. | β | 1999 | β |
| Temporal modulation of GABA(A) receptor subunit gene expression in developing monkey cerebral cortex. | Huntsman MM et al. | β | 1999 | β |
| The GABA-A receptor gene family: new targets for therapeutic intervention. | Whiting PJ | β | 1999 | β |
| The safety and tolerability of zolpidem--an update. | Darcourt G et al. | β | 1999 | β |
| Transcriptional regulation of GABAA receptor gamma2 subunit gene. | Mu W et al. | β | 1999 | β |
| Waglerin-1 inhibits GABA(A) current of neurons in the nucleus accumbens of neonatal rats. | Ye JH et al. | β | 1999 | β |
| Absence of association between delta and gamma2 subunits in native GABA(A) receptors from rat brain. | Araujo F et al. | β | 1998 | β |
| Adjacent phosphorylation sites on GABAA receptor beta subunits determine regulation by cAMP-dependent protein kinase. | McDonald BJ et al. | β | 1998 | β |
| Alterations in GABAA receptor alpha 1 and alpha 4 subunit mRNA levels in thalamic relay nuclei following absence-like seizures in rats. | Banerjee PK et al. | β | 1998 | β |
| Altered ratios of alternatively spliced long and short gamma2 subunit mRNAs of the gamma-amino butyrate type A receptor in prefrontal cortex of schizophrenics. | Huntsman MM et al. | β | 1998 | β |
| A protein tyrosine kinase modulates GABAA receptor in frog pituitary melanotrope cells. | Castel H et al. | β | 1998 | β |
| Chicken GABA(A) receptor beta4 subunits form robust homomeric GABA-gated channels in Xenopus oocytes. | Liu SC et al. | β | 1998 | β |
| Combination of open field and elevated plus-maze: a suitable test battery to assess strain as well as treatment differences in rat behavior. | Schmitt U et al. | β | 1998 | β |
| Dentate gyrus basket cell GABAA receptors are blocked by Zn2+ via changes of their desensitization kinetics: an in situ patch-clamp and single-cell PCR study. | Berger T et al. | β | 1998 | β |
| Effects of moderate alcohol consumption on the central nervous system. | Eckardt MJ et al. | β | 1998 | β |
| Entrainment of the circadian system of mammals by nonphotic cues. | Hastings MH et al. | β | 1998 | β |
| Expression of 10 GABA(A) receptor subunit messenger RNAs in the motor-related thalamic nuclei and basal ganglia of Macaca mulatta studied with in situ hybridization histochemistry. | Kultas-Ilinsky K et al. | β | 1998 | β |
| Expression of alpha3, beta3 and gamma1 GABA(A) receptor subunit messenger RNAs in visual cortex and lateral geniculate nucleus of normal and monocularly deprived monkeys. | Huntsman MM et al. | β | 1998 | β |
| From GABAA receptor diversity emerges a unified vision of GABAergic inhibition. | Costa E | β | 1998 | β |
| Functional characteristics of recombinant human GABA(A) receptors containing the epsilon-subunit. | Thompson SA et al. | β | 1998 | β |
| GABA(A) receptor function in epileptic human dentate granule cells: comparison to epileptic and control rat. | Shumate MD et al. | β | 1998 | β |
| GABAA receptor-mediated currents in interneurons and pyramidal cells of rat visual cortex. | Xiang Z et al. | β | 1998 | β |
| GABAA receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells. | Neelands TR et al. | β | 1998 | β |
| GABAergic deafferentation hypothesis of brain aging and Alzheimer's disease revisited. | Marczynski TJ | β | 1998 | β |
| GABA, GABA transporters, GABA(A) receptor subunits, and GAD mRNAs in the rat parabrachial and KΓΆlliker-Fuse nuclei. | Guthmann A et al. | β | 1998 | β |
| Heritable mutations in the glycine, GABAA, and nicotinic acetylcholine receptors provide new insights into the ligand-gated ion channel receptor superfamily. | Vafa B et al. | β | 1998 | β |
| Modulatory and direct effects of propofol on recombinant GABAA receptors expressed in xenopus oocytes: influence of alpha- and gamma2-subunits. | Lam DW et al. | β | 1998 | β |
| Molecular and functional adaptation of the GABA(A) receptor complex during pregnancy and after delivery in the rat brain. | Follesa P et al. | β | 1998 | β |
| Molecular modulation of recombinant rat alpha1beta2gamma2 GABA(A) receptor channels by diazepam. | Krampfl K et al. | β | 1998 | β |
| Molecular structure and stereoelectronic properties of sarmazenil--a weak inverse agonist at the omega modulatory sites (benzodiazepine receptors): comparison with bretazenil and flumazenil. | LΓ³pez-Romero B et al. | β | 1998 | β |
| Neuroactive steroids exacerbate gamma-hydroxybutyric acid-induced absence seizures in rats. | Banerjee PK et al. | β | 1998 | β |
| Oleamide potentiates benzodiazepine-sensitive gamma-aminobutyric acid receptor activity but does not alter minimum alveolar anesthetic concentration. | Yost CS et al. | β | 1998 | β |
| Pharmacological and functional implications of developmentally-regulated changes in GABA(A) receptor subunit expression in the cerebellum. | Carlson BX et al. | β | 1998 | β |
| Plasma concentrations of endogenous benzodiazepine-receptor ligands in patients with hepatic encephalopathy: a comparative study. | HernΓ‘ndez-Avila CA et al. | β | 1998 | β |
| Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane. | Krasowski MD et al. | β | 1998 | β |
| Role of brain allopregnanolone in the plasticity of gamma-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery. | Concas A et al. | β | 1998 | β |
| SB-205384: a GABA(A) receptor modulator with novel mechanism of action that shows subunit selectivity. | Meadows HJ et al. | β | 1998 | β |
| The antiepileptic drug AWD 131-138 stimulates different recombinant isoforms of the rat GABA(A) receptor through the benzodiazepine binding site. | Sigel E et al. | β | 1998 | β |
| The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes. | Hevers W et al. | β | 1998 | β |
| The GABA(A) receptor gamma1-subunit in seizure prone (DBA/2) and resistant (C57BL/6) mice. | Wang JB et al. | β | 1998 | β |
| Using knockout and transgenic mice to study neurophysiology and behavior. | Picciotto MR et al. | β | 1998 | β |
| Zinc and zolpidem modulate mIPSCs in rat neocortical pyramidal neurons. | Defazio T et al. | β | 1998 | β |
| Action of furosemide on GABA- and glycine currents in rat septal cholinergic neurons in culture. | Kumamoto E et al. | β | 1997 | β |
| Action of zolpidem on responses to GABA in relation to mRNAs for GABA(A) receptor alpha subunits within single cells: evidence for multiple functional GABA(A) isoreceptors on individual neurons. | Criswell HE et al. | β | 1997 | β |
| Activation and deactivation rates of recombinant GABA(A) receptor channels are dependent on alpha-subunit isoform. | Lavoie AM et al. | β | 1997 | β |
| A gene in human chromosome band Xq28 (GABRE) defines a putative new subunit class of the GABAA neurotransmitter receptor. | Wilke K et al. | β | 1997 | β |
| Alpha subunit isoform influences GABA(A) receptor modulation by propofol. | Krasowski MD et al. | β | 1997 | β |
| Alterations of the benzodiazepine site of rat alpha 6 beta 2 gamma 2-GABAA receptor by replacement of several divergent amino-terminal regions with the alpha 1 counterparts. | Im WB et al. | β | 1997 | β |
| Antiepileptic drug cellular mechanisms of action: where does lamotrigine fit in? | Coulter DA | β | 1997 | β |
| A point mutation in the gamma2 subunit of gamma-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity. | Buhr A et al. | β | 1997 | β |
| Area and lamina-specific expression of GABAA receptor subunit mRNAs in monkey cerebral cortex. | Jones EG | β | 1997 | β |
| A review of pharmacotherapeutics for prosthetic dentistry: Part II. | Felpel LP | β | 1997 | β |
| Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs. | White HS | β | 1997 | β |
| Clozapine and some other antipsychotic drugs may preferentially block the same subset of GABA(A) receptors. | Squires RF et al. | β | 1997 | β |
| Clustering of GABAA receptors by rapsyn/43kD protein in vitro. | Yang SH et al. | β | 1997 | β |
| Commentary on the use of immortalized neuroendocrine cell lines for physiological research. | Selmanoff M | β | 1997 | β |
| D-2-hydroxyglutaric aciduria: hypotonia, cortical blindness, seizures, cardiomyopathy, and cylindrical spirals in skeletal muscle. | Baker NS et al. | β | 1997 | β |
| Decreased agonist sensitivity of human GABA(A) receptors by an amino acid variant, isoleucine to valine, in the alpha1 subunit. | Westh-Hansen SE et al. | β | 1997 | β |
| Developmental expression of chick cortical GABA(A) receptor alpha1 subunits in vivo and in vitro. | Miranda JD et al. | β | 1997 | β |
| Development of stable cell lines expressing different subtypes of GABAA receptors. | Besnard F et al. | β | 1997 | β |
| Diazepam enhancement of GABA-gated currents in binary and ternary GABAA receptors: relationship to benzodiazepine binding site density. | Granja R et al. | β | 1997 | β |
| Diazepam protects against rat hippocampal neuronal cell death induced by antisense oligodeoxynucleotide to GABA(A) receptor gamma2 subunit. | Karle J et al. | β | 1997 | β |
| Diazepam-sensitive GABA(A) receptors in the NTS participate in cardiovascular control. | Barron KW et al. | β | 1997 | β |
| Differences in expression of GABAA receptor subunits, but not benzodiazepine binding, in the chick brainstem auditory system. | Hyson RL et al. | β | 1997 | β |
| Differences in synaptic GABA(A) receptor number underlie variation in GABA mini amplitude. | Nusser Z et al. | β | 1997 | β |
| Differential changes in induced seizures after hippocampal treatment of rats with an antisense oligodeoxynucleotide to the GABA(A) receptor gamma2 subunit. | Karle J et al. | β | 1997 | β |
| Excitatory neurotransmission and sexual differentiation of the brain. | McCarthy MM et al. | β | 1997 | β |
| Furosemide interactions with brain GABAA receptors. | Korpi ER et al. | β | 1997 | β |
| GABAA receptor subunit expression changes in the rat cerebellum and cerebral cortex during aging. | GutiΓ©rrez A et al. | β | 1997 | β |
| Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit. | Davies PA et al. | β | 1997 | β |
| Intravenous anaesthetics: some cellular sites of action. | Dzoljic M et al. | β | 1997 | β |
| Key amino acids in the gamma subunit of the gamma-aminobutyric acidA receptor that determine ligand binding and modulation at the benzodiazepine site. | Wingrove PB et al. | β | 1997 | β |
| Modulation by general anaesthetics of rat GABAA receptors comprised of alpha 1 beta 3 and beta 3 subunits expressed in human embryonic kidney 293 cells. | Davies PA et al. | β | 1997 | β |
| Molecular pathogenesis of alcohol withdrawal seizures: the modified lipid-protein interaction mechanism. | Tan CY et al. | β | 1997 | β |
| Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties [corrected; erratum to be published]. | Whiting PJ et al. | β | 1997 | β |
| Physiological and pharmacological alterations in postsynaptic GABA(A) receptor function in a hippocampal culture model of chronic spontaneous seizures. | Gibbs JW et al. | β | 1997 | β |
| PNU-107484A with alpha isoform-dependent functional changes in alpha(x)beta2gamma2 subtypes of rat recombinant GABA(A) receptors. | Im HK et al. | β | 1997 | β |
| Polymorphisms and intron sequences flanking the alternatively spliced 8-amino-acid exon of gamma2 subunit gene for GABAA receptors. | Cheng AT et al. | β | 1997 | β |
| Rapid seizure-induced reduction of benzodiazepine and Zn2+ sensitivity of hippocampal dentate granule cell GABAA receptors. | Kapur J et al. | β | 1997 | β |
| Regional densities of benzodiazepine sites in the CNS of alcohol-naive P and NP rats. | Thielen RJ et al. | β | 1997 | β |
| Regulation of GABA(A) receptor subunit mRNA expression by the pesticide dieldrin in embryonic brainstem cultures: a quantitative, competitive reverse transcription-polymerase chain reaction study. | Liu J et al. | β | 1997 | β |
| Repression of gamma-aminobutyric acid type A receptor alpha1 polypeptide biosynthesis requires chronic agonist exposure. | Miranda JD et al. | β | 1997 | β |
| Residues at positions 206 and 209 of the alpha1 subunit of gamma-aminobutyric AcidA receptors influence affinities for benzodiazepine binding site ligands. | Buhr A et al. | β | 1997 | β |
| Subtle changes in residue 77 of the gamma subunit of alpha1beta2gamma2 GABAA receptors drastically alter the affinity for ligands of the benzodiazepine binding site. | Buhr A et al. | β | 1997 | β |
| The pharmacology of amino-acid responses in septal neurons. | Kumamoto E | β | 1997 | β |
| The role of the GABA(A) receptor alpha1 subunit N-terminal extracellular domain in propofol potentiation of chloride current. | Uchida I et al. | β | 1997 | β |
| The use of in vivo antisense oligonucleotide technology for the investigation of brain GABA receptors. | Karle J et al. | β | 1997 | β |
| Tolerance to diazepam and changes in GABA(A) receptor subunit expression in rat neocortical areas. | Pesold C et al. | β | 1997 | β |
| 1,4-Benzodiazepine derivatives as anticonvulsant agents in DBA/2 mice. | De Sarro G et al. | β | 1996 | β |
| 3-Phenyl-substituted imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas that have high affinity at the GABAA/benzodiazepine receptor complex. | Jacobsen EJ et al. | β | 1996 | β |
| A functional comparison of the antagonists bicuculline and picrotoxin at recombinant GABAA receptors. | Krishek BJ et al. | β | 1996 | β |
| Aging-related subunit expression changes of the GABAA receptor in the rat hippocampus. | GutiΓ©rrez A et al. | β | 1996 | β |
| Alcohol, alcoholic brain damage, and GABAA receptor isoform gene expression. | Lewohl JM et al. | β | 1996 | β |
| Allosteric modulation of an expressed homo-oligomeric GABA-gated chloride channel of Drosophila melanogaster. | Hosie AM et al. | β | 1996 | β |
| Altered expression of gamma 2L and gamma 2S GABAA receptor subunits in the aging rat brain. | GutiΓ©rrez A et al. | β | 1996 | β |
| An autoradiographic study of [3H]flunitrazepam binding sites in the brain of rat made tolerant to and dependent on pentobarbital. | Suzuki T et al. | β | 1996 | β |
| Anticonvulsant drug effects on spontaneous thalamocortical rhythms in vitro: valproic acid, clonazepam, and alpha-methyl-alpha-phenylsuccinimide. | Zhang YF et al. | β | 1996 | β |
| Assembly and cell surface expression of heteromeric and homomeric gamma-aminobutyric acid type A receptors. | Connolly CN et al. | β | 1996 | β |
| Azirino[1, 2-d][1, 4]benzodiazepine derivatives and related 1,4-benzodiazepines as anticonvulsant agents in DBA/2 mice. | De Sarro G et al. | β | 1996 | β |
| Biochemical evaluations of the effects of loreclezole and propofol on the GABAA receptor in rat brain. | Ghiani CA et al. | β | 1996 | β |
| Blunted furosemide action on cerebellar GABAA receptors in ANT rats selectively bred for high alcohol sensitivity. | MΓ€kelΓ€ R et al. | β | 1996 | β |
| Brain GABAA receptors studied with subunit-specific antibodies. | De Blas AL | β | 1996 | β |
| Characterization of U-101017 as a GABA(A) receptor ligand of dual functionality. | Im HK et al. | β | 1996 | β |
| Chimeric GABAA/glycine receptors: expression and barbiturate pharmacology. | Koltchine VV et al. | β | 1996 | β |
| Delta subunit inhibits neurosteroid modulation of GABAA receptors. | Zhu WJ et al. | β | 1996 | β |
| Developmental expression of functional GABAA receptors containing the gamma 2 subunit in neurons derived from embryonal carcinoma (P19) cells. | Reynolds JN et al. | β | 1996 | β |
| Developmental profile of GABAA-receptors in the marmoset monkey: expression of distinct subtypes in pre- and postnatal brain. | Hornung JP et al. | β | 1996 | β |
| Differential effects of hexachlorocyclohexane isomers on the GABA receptor subunits expressed in human embryonic kidney cell line. | Nagata K et al. | β | 1996 | β |
| Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. | Sanna E et al. | β | 1996 | β |
| Direct evidence for diazepam modulation of GABAA receptor microscopic affinity. | Lavoie AM et al. | β | 1996 | β |
| Distinct deactivation and desensitization kinetics of recombinant GABAA receptors. | Tia S et al. | β | 1996 | β |
| Effects of ethanol on ion channels. | Crews FT et al. | β | 1996 | β |
| Excitatory and inhibitory amino acids and synaptic transmission in the suprachiasmatic nucleus. | van den Pol AN et al. | β | 1996 | β |
| GABA and GABA-A receptors are maximally expressed in association with cone synaptogenesis in neonatal rabbit retina. | Mitchell CK et al. | β | 1996 | β |
| GABAA receptor pharmacology. | Johnston GA | β | 1996 | β |
| GABAA receptor subunit expression and assembly in cultured rat cerebellar granule neurons. | Nadler LS et al. | β | 1996 | β |
| gamma-aminobutyric acidA receptor regulation: heterologous uncoupling of modulatory site interactions induced by chronic steroid, barbiturate, benzodiazepine, or GABA treatment in culture. | Friedman LK et al. | β | 1996 | β |
| Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors. | So SS et al. | β | 1996 | β |
| High-affinity alpha-aminobutyric acid A/benzodiazepine ligands: synthesis and structure-activity relationship studies of a new series of tetracyclic imidazoquinoxalines. | Mickelson JW et al. | β | 1996 | β |
| High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex. | Jacobsen EJ et al. | β | 1996 | β |
| Identifiable Achatina giant neurones: their localizations in ganglia, axonal pathways and pharmacological features. | Takeuchi H et al. | β | 1996 | β |
| Inhibition of GABAA ligand-gated Cl- channels by zinc in adult rat brain: a regional study. | Ito Y et al. | β | 1996 | β |
| Intrathecally administered flumazenil and PK 11195 precipitate abstinence syndrome in freely moving diazepam dependent rats. | Wala EP et al. | β | 1996 | β |
| Lanthanum and zinc sensitivity of GABAA-activated currents in adult medial septum/diagonal band neurons from ethanol dependent rats. | Frye GD et al. | β | 1996 | β |
| Localization of GABAA alpha 1 mRNA subunit in the brainstem nuclei controlling esophageal peristalsis. | Broussard DL et al. | β | 1996 | β |
| Modulation of amino acid-gated ion channels by protein phosphorylation. | Moss SJ et al. | β | 1996 | β |
| Modulation of synaptic GABAA receptor function by benzodiazepines in area CA3 of rat hippocampal slice cultures. | Poncer JC et al. | β | 1996 | β |
| Molecular and pharmacological characterization of native cortical gamma-aminobutyric acidA receptors containing both alpha1 and alpha3 subunits. | Araujo F et al. | β | 1996 | β |
| Molecular mechanisms of benzodiazepine-induced down-regulation of GABAA receptor alpha 1 subunit protein in rat cerebellar granule cells. | Brown MJ et al. | β | 1996 | β |
| Nucleus-specific expression of GABA(A) receptor subunit mRNAs in monkey thalamus. | Huntsman MM et al. | β | 1996 | β |
| Pharmacological profile of benzodiazepine site ligands with recombinant GABAA receptor subtypes. | Graham D et al. | β | 1996 | β |
| Pharmacological properties of recombinant "diazepam-insensitive" GABAA receptors. | Gunnersen D et al. | β | 1996 | β |
| Physiological comparison of alpha-ethyl-alpha-methyl-gamma-thiobutyrolactone with benzodiazepine and barbiturate modulators of GABAA receptors. | Mathews GC et al. | β | 1996 | β |
| Plasticity in GABAA receptor subunit mRNA expression by hypothalamic magnocellular neurons in the adult rat. | FΓ©nelon VS et al. | β | 1996 | β |
| Proton modulation of functionally distinct GABAA receptors in acutely isolated pyramidal neurons of rat hippocampus. | Pasternack M et al. | β | 1996 | β |
| Proton sensitivity of the GABA(A) receptor is associated with the receptor subunit composition. | Krishek BJ et al. | β | 1996 | β |
| Recombinant GABAA receptor desensitization: the role of the gamma 2 subunit and its physiological significance. | Dominguez-Perrot C et al. | β | 1996 | β |
| Ro 15-4513 alteration of pentobarbital dependence. | Yutrzenka GJ et al. | β | 1996 | β |
| Selective expression and rapid regulation of GABAA receptor subunits in geniculocortical neurons of macaque dorsal lateral geniculate nucleus. | Hendry SH et al. | β | 1996 | β |
| Stoichiometry of a recombinant GABAA receptor. | Chang Y et al. | β | 1996 | β |
| Structural and pharmacological aspects of the GABAA receptor: involvement in behavioral pathogenesis. | ClΓ©ment Y | β | 1996 | β |
| Subunit stoichiometry of oligomeric membrane proteins: GABAA receptors isolated by selective immunoprecipitation from the cell surface. | Kellenberger S et al. | β | 1996 | β |
| The alpha 4 subunit of the GABAA receptors from rat brain and retina. | Khan ZU et al. | β | 1996 | β |
| The gamma 2 subunit of the GABAA receptor is concentrated in synaptic junctions containing the alpha 1 and beta 2/3 subunits in hippocampus, cerebellum and globus pallidus. | Somogyi P et al. | β | 1996 | β |
| The gamma subunits of the native GABAA/benzodiazepine receptors. | Khan ZU et al. | β | 1996 | β |
| Thyroid hormonal modulation of the binding and activity of the GABAA receptor complex of brain. | Martin JV et al. | β | 1996 | β |
| Treatment with an antisense oligodeoxynucleotide to the GABAA receptor gamma 2 subunit increases convulsive threshold for beta-CCM, a benzodiazepine "inverse agonist', in rats. | Zhao TJ et al. | β | 1996 | β |
| Which GABAA-receptor subtypes really occur in the brain? | McKernan RM et al. | β | 1996 | β |
| Wild-type and insecticide-resistant homo-oligomeric GABA receptors of Drosophila melanogaster stably expressed in a Drosophila cell line. | Buckingham SD et al. | β | 1996 | β |
| Zinc modulation of bicuculline-sensitive and -insensitive GABA receptors in the developing rat hippocampus. | Martina M et al. | β | 1996 | β |
| 2,3-Butanedione monoxime protects mice against the convulsant effect of picrotoxin by facilitating GABA-activated currents. | Brightman T et al. | β | 1995 | β |
| Acceleration of GABA-dependent desensitization by mutating threonine 266 to alanine of the alpha 6 subunit of rat GABAA receptors. | Im WB et al. | β | 1995 | β |
| Age-related levels of GABA/benzodiazepine binding sites in cerebrum of F-344 rats: effects of exercise. | Tehrani MH et al. | β | 1995 | β |
| Antiepileptic drug mechanisms of action. | Macdonald RL et al. | β | 1995 | β |
| Antisense oligonucleotide to GABAA receptor gamma 2 subunit induces loss of neurones in rat hippocampus. | Karle J et al. | β | 1995 | β |
| Assessment of the interaction between a partial agonist and a full agonist of benzodiazepine receptors, based on psychomotor performance and memory, in healthy volunteers. | Patat A et al. | β | 1995 | β |
| Benzodiazepine-GABAA receptor binding during absence seizures. | Prevett MC et al. | β | 1995 | β |
| Benzodiazepine-GABAA receptors in idiopathic generalized epilepsy measured with [11C]flumazenil and positron emission tomography. | Prevett MC et al. | β | 1995 | β |
| Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors. | GΓΌnther U et al. | β | 1995 | β |
| Biological function of GABAA/benzodiazepine receptor heterogeneity. | LΓΌddens H et al. | β | 1995 | β |
| Cellular localization and differential distribution of GABAA receptor subunit proteins and messenger RNAs within hypothalamic magnocellular neurons. | Fenelon VS et al. | β | 1995 | β |
| Cerebral GABAA and GABAB receptors. Structure and function. | Nakayasu H et al. | β | 1995 | β |
| Characterisation of GABAA receptor gamma subunit expression by magnocellular neurones in rat hypothalamus. | Fenelon VS et al. | β | 1995 | β |
| Characterization of a benzodiazepine receptor site with exceptionally high affinity for Ro 15-4513 in the rat CNS. | Mehta AK et al. | β | 1995 | β |
| Characterization of novel ligands for wild-type and natural mutant diazepam-insensitive benzodiazepine receptors. | Wong G et al. | β | 1995 | β |
| Chloride channel expression with the tandem construct of alpha 6-beta 2 GABAA receptor subunit requires a monomeric subunit of alpha 6 or gamma 2. | Im WB et al. | β | 1995 | β |
| Chronic administration of the antidepressants phenelzine, desipramine, clomipramine, or maprotiline decreases binding to 5-hydroxytryptamine2A receptors without affecting benzodiazepine binding sites in rat brain. | Todd KG et al. | β | 1995 | β |
| Chronic exposure to stress levels of corticosterone alters GABAA receptor subunit mRNA levels in rat hippocampus. | Orchinik M et al. | β | 1995 | β |
| Deciphering the native GABAA receptor: is there hope? | Yeh HH et al. | β | 1995 | β |
| Dependence of the GABAA receptor gating kinetics on the alpha-subunit isoform: implications for structure-function relations and synaptic transmission. | Gingrich KJ et al. | β | 1995 | β |
| Depolarizing GABA-activated Cl- channels in embryonic rat spinal and olfactory bulb cells. | Serafini R et al. | β | 1995 | β |
| Differential distribution of GABAA receptor subunits in soma and processes of cerebellar granule cells: effects of maturation and a GABA agonist. | Elster L et al. | β | 1995 | β |
| Differential effects of hexachlorocyclohexane isomers on the GABA receptor-chloride channel complex in rat dorsal root ganglion neurons. | Nagata K et al. | β | 1995 | β |
| Distribution of [3H]zolpidem binding sites in relation to messenger RNA encoding the alpha 1, beta 2 and gamma 2 subunits of GABAA receptors in rat brain. | Duncan GE et al. | β | 1995 | β |
| DNA sequence and site of mutation of the GABA receptor of cyclodiene-resistant red flour beetle, Tribolium castaneum. | Miyazaki M et al. | β | 1995 | β |
| Effects of ethanol on recombinant rat GABAA receptors: [35S]t-butylbicyclophosphorothionate ([35S]TBPS) binding study. | Korpi ER et al. | β | 1995 | β |
| Endogenous [3H]flunitrazepam binding in human embryonic kidney cell line 293. | Fuchs K et al. | β | 1995 | β |
| Ethanol, gamma-aminobutyrate type A receptors, and protein kinase C phosphorylation. | Macdonald RL | β | 1995 | β |
| Ethanol withdrawal induces increased firing in inferior colliculus neurons associated with audiogenic seizure susceptibility. | Faingold CL et al. | β | 1995 | β |
| Expression and pharmacology of human GABAA receptors containing gamma 3 subunits. | Hadingham KL et al. | β | 1995 | β |
| Expression of functional GABAA receptors in neuroendocrine gastropancreatic cells. | von Blankenfeld G et al. | β | 1995 | β |
| Expression patterns and deprivation effects on GABAA receptor subunit and GAD mRNAs in monkey lateral geniculate nucleus. | Huntsman MM et al. | β | 1995 | β |
| From ion currents to genomic analysis: recent advances in GABAA receptor research. | Rabow LE et al. | β | 1995 | β |
| GABAA/benzodiazepine receptor heterogeneity: neurophysiological implications. | LΓΌddens H et al. | β | 1995 | β |
| GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions. | O'Hara BF et al. | β | 1995 | β |
| GABAA-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. | Fritschy JM et al. | β | 1995 | β |
| Heterogeneity of GABAA-receptors: cell-specific expression, pharmacology, and regulation. | Mohler H et al. | β | 1995 | β |
| Identification of distinct GABAA-receptor subtypes in cholinergic and parvalbumin-positive neurons of the rat and marmoset medial septum-diagonal band complex. | Gao B et al. | β | 1995 | β |
| Interaction of abecarnil, bretazenil, and RO 19-8022 with diazepam-sensitive and -insensitive benzodiazepine sites in the rat cerebellum and cerebral cortex. | Mehta AK et al. | β | 1995 | β |
| Interaction of beta-carboline inverse agonists for the benzodiazepine site with another site on GABAA receptors. | Im HK et al. | β | 1995 | β |
| Laminar patterns of expression of GABA-A receptor subunit mRNAs in monkey sensory motor cortex. | Huntsman MM et al. | β | 1995 | β |
| Modest reduction of benzodiazepine binding in rat brain in vivo induced by antisense oligonucleotide to GABAA receptor gamma 2 subunit subtype. | Karle J et al. | β | 1995 | β |
| Modulation of GABAA receptors by tyrosine phosphorylation. | Moss SJ et al. | β | 1995 | β |
| Modulatory actions of gamma aminobutyric acid (GABA) on GABA type A receptor subunit expression and function. | Schousboe A et al. | β | 1995 | β |
| Molecular diversity of GABA-gated chloride channels in the rat anterior pituitary. | BouΓ©-Grabot E et al. | β | 1995 | β |
| Neonatal rat cerebellar granule and Purkinje neurons in culture express different GABAA receptors. | Zempel JM et al. | β | 1995 | β |
| Ontogeny and topography of seizure regulation by the substantia nigra. | MoshΓ© SL et al. | β | 1995 | β |
| Pharmacological modulation of adrenal medullary GABAA receptor: consistent with its subunit composition. | ParramΓ³n M et al. | β | 1995 | β |
| Potentiation, activation and blockade of GABAA receptors of clonal murine hypothalamic GT1-7 neurones by propofol. | Adodra S et al. | β | 1995 | β |
| Regulation of GABAA receptor function and gene expression in the central nervous system. | Morrow AL | β | 1995 | β |
| State-dependent effects of atypical benzodiazepine-receptor agonists. | Jackson A | β | 1995 | β |
| Stereospecific transduction of behavioral effects via diazepam-insensitive GABAA receptors. | Acri JB et al. | β | 1995 | β |
| Structure and distribution of multiple GABAA receptor subunits with special reference to the cerebellum. | Wisden W | β | 1995 | β |
| Structure and pharmacology of vertebrate GABAA receptor subtypes. | Whiting PJ et al. | β | 1995 | β |
| Subcellular localization of the GABAA receptor gamma 2 subunit in the rat spinal cord. | Sur C et al. | β | 1995 | β |
| Subtype specificity of gamma-aminobutyric acid type A receptor antagonism by clozapine. | Korpi ER et al. | β | 1995 | β |
| The enhancement of muscimol-stimulated 36C1 influx by the antispastic 5-aryl-3-(alkylsulfonyl)-4H-1,2,4-triazole (MDL 27,531) in rat brain membrane vesicles. | Miller JA et al. | β | 1995 | β |
| The GABAA receptors. | Stephenson FA | β | 1995 | β |
| The pharmacology of the benzodiazepine site of the GABA-A receptor is dependent on the type of gamma-subunit present. | McKernan RM et al. | β | 1995 | β |
| A novel allosteric modulatory site on the GABAA receptor beta subunit. | Wafford KA et al. | β | 1994 | β |
| A single amino acid of the human gamma-aminobutyric acid type A receptor gamma 2 subunit determines benzodiazepine efficacy. | Mihic SJ et al. | β | 1994 | β |
| Benzodiazepine and beta-carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture. | Rogers CJ et al. | β | 1994 | β |
| beta-Lumicolchicine interacts with the benzodiazepine binding site to potentiate GABAA receptor-mediated currents. | Mihic SJ et al. | β | 1994 | β |
| Coexpression of GABAA receptor gamma 1 and gamma 2 subunits in the rat trigeminal ganglion. | Kondo E et al. | β | 1994 | β |
| Coincidental appearance of the alpha 1 subunit of the GABA-A receptor and the type I benzodiazepine receptor near birth in macaque monkey visual cortex. | Hendrickson A et al. | β | 1994 | β |
| Decreased expression of gamma-aminobutyric acid type A/benzodiazepine receptor beta subunit mRNAs in brain of flurazepam-tolerant rats. | Zhao TJ et al. | β | 1994 | β |
| Development pattern of the GABAA-benzodiazepine receptor ionophore complex in primary cultures of cortical neurons. | Hu XJ et al. | β | 1994 | β |
| Different functional effect of Ro 15-4513 and Ro 19-4603 on synaptic responses of Purkinje cells in the rat cerebellar slice. | Pringle AK et al. | β | 1994 | β |
| Differential effects of GABAergic ligands in mouse and rat hippocampal neurons. | Aguayo LG et al. | β | 1994 | β |
| Differential expression of the short and long forms of the gamma 2 subunit of the GABAA/benzodiazepine receptors. | Miralles CP et al. | β | 1994 | β |
| Distribution of GABAA and GABAB binding sites in the cochlear nucleus of the guinea pig. | Juiz JM et al. | β | 1994 | β |
| Distribution, prevalence, and drug binding profile of gamma-aminobutyric acid type A receptor subtypes differing in the beta-subunit variant. | Benke D et al. | β | 1994 | β |
| Effects of GABA and various allosteric ligands on TBPS binding to cloned rat GABA(A) receptor subtypes. | Im WB et al. | β | 1994 | β |
| Effects of valine, leucine, isoleucine, and a balanced amino acid solution on the seizure threshold to picrotoxin in rats. | Skeie B et al. | β | 1994 | β |
| Expression and localization of gamma-aminobutyric acid A (GABAA) receptor alpha 1 subunit and L-glutamate decarboxylase (GAD) mRNAs in rat retina: an analysis by in situ hybridization. | Kosaka J et al. | β | 1994 | β |
| Expression of GABAA receptor gamma 1 and gamma 2 subunits in the peripheral vestibular system of the rat. | Kitahara T et al. | β | 1994 | β |
| Expression profiling of GABAA receptor beta-subunits in the rat retina. | Grigorenko EV et al. | β | 1994 | β |
| Fibrous and protoplasmic astrocytes express GABAA receptors that differ in benzodiazepine pharmacology. | Rosewater K et al. | β | 1994 | β |
| Functional diversity of GABA-activated Cl- currents in Purkinje versus granule neurons in rat cerebellar slices. | Puia G et al. | β | 1994 | β |
| GABAA receptor-mediated inhibition of N-methyl-D-aspartate-evoked [3H]dopamine release from mesencephalic cell cultures. | Chaudieu I et al. | β | 1994 | β |
| GABAA receptors on rat cerebellar granule cells are potently activated by muscimol but only slightly modulated by the benzodiazepine agonist flunitrazepam. | Baldelli P et al. | β | 1994 | β |
| GABAA receptor subunit polypeptides increase in parallel but exhibit distinct distributions in the developing rat cerebellum. | Nadler LS et al. | β | 1994 | β |
| gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties. | TΓΆgel M et al. | β | 1994 | β |
| gamma-Aminobutyric acid (GABA): a fast excitatory transmitter which may regulate the development of hippocampal neurones in early postnatal life. | Ben-Ari Y et al. | β | 1994 | β |
| Identification of a [3H]muscimol photoaffinity substrate in the bovine gamma-aminobutyric acidA receptor alpha subunit. | Smith GB et al. | β | 1994 | β |
| Identification of GABAA receptor subunits expressed in bovine adrenal medulla. | ParramΓ³n M et al. | β | 1994 | β |
| Immunoaffinity purification of gamma-aminobutyric acidA (GABAA) receptors containing gamma 1-subunits. Evidence for the presence of a single type of gamma-subunit in GABAA receptors. | Mossier B et al. | β | 1994 | β |
| Localization of GABAA receptor subunit mRNAs in the rat locus coeruleus. | Luque JM et al. | β | 1994 | β |
| Mechanisms of action of currently prescribed and newly developed antiepileptic drugs. | Macdonald RL et al. | β | 1994 | β |
| Model of subunit composition of gamma-aminobutyric acid A receptor subtypes expressed in rat cerebellum with respect to their alpha and gamma/delta subunits. | Quirk K et al. | β | 1994 | β |
| Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc. | Smart TG et al. | β | 1994 | β |
| Modulation of inhibitory synaptic transmission in the hippocampus. | Thompson SM | β | 1994 | β |
| Molecular characterization of type I GABAA receptor complex from rat cerebral cortex and hippocampus. | Ruano D et al. | β | 1994 | β |
| Molecular determinants of recognition and activation at the cerebellar benzodiazepine receptor site. | Schove LT et al. | β | 1994 | β |
| Molecular heterogeneity of the type I GABAA/benzodiazepine receptor complex. | Ruano D et al. | β | 1994 | β |
| Molecular neurobiology of the GABAA receptor. | Dunn SM et al. | β | 1994 | β |
| Recent developments in the behavioral pharmacology of benzodiazepine (omega) receptors: evidence for the functional significance of receptor subtypes. | Sanger DJ et al. | β | 1994 | β |
| Regulation of GABAA receptor function by protein kinase C phosphorylation. | Krishek BJ et al. | β | 1994 | β |
| Selective effects of dieldrin on the GABAA receptor-channel subunits expressed in human embryonic kidney cells. | Nagata K et al. | β | 1994 | β |
| Subunit- and brain region-specific reduction of GABAA receptor subunit mRNAs during chronic treatment of rats with diazepam. | Wu Y et al. | β | 1994 | β |
| The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. | Wingrove PB et al. | β | 1994 | β |
| The origin of synaptic neuroplasticity: crucial molecules or a dynamical cascade? | Shaw CA et al. | β | 1994 | β |
| Toward the complete genomic map and molecular pathology of human chromosome 4. | Riess O et al. | β | 1994 | β |
| Trichloroethanol potentiation of gamma-aminobutyric acid-activated chloride current in mouse hippocampal neurones. | Peoples RW et al. | β | 1994 | β |
| Zinc inhibition of GABA-stimulated Cl- influx in rat brain regions is unaffected by acute or chronic benzodiazepine. | Li M et al. | β | 1994 | β |
| Alcohol modulation of cloned GABAA receptor-channel complex expressed in human kidney cell lines. | Kurata Y et al. | β | 1993 | β |
| Analysis of gamma-aminobutyric acidA receptor subunits in the mouse cochlea by means of the polymerase chain reaction. | Drescher DG et al. | β | 1993 | β |
| Antagonist inhibition of GABAA-mediated chloride uptake is atypical in nigrocollicular areas. | Peris J | β | 1993 | β |
| Antibodies specific for alpha-subunit subtypes of GABAA receptors reveal brain regional heterogeneity. | Endo S et al. | β | 1993 | β |
| Antibodies to the human gamma 2 subunit of the gamma-aminobutyric acidA/benzodiazepine receptor. | Khan ZU et al. | β | 1993 | β |
| Antiepileptic drug mechanisms of action. | Macdonald RL et al. | β | 1993 | β |
| A point mutation in a Drosophila GABA receptor confers insecticide resistance. | Ffrench-Constant RH et al. | β | 1993 | β |
| Assembly of GABAA receptor subunits determines sorting and localization in polarized cells. | Perez-Velazquez JL et al. | β | 1993 | β |
| Benzodiazepine binding to GABAA receptors: differential effects of sulfhydryl modification. | Duncalfe LL et al. | β | 1993 | β |
| Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABAA receptor. | Korpi ER et al. | β | 1993 | β |
| Benzodiazepine inverse agonists augment long-term potentiation in CA1 and CA3 of guinea pig hippocampal slices. | Yasui M et al. | β | 1993 | β |
| Characterization of substantia nigra pars reticulata neurons based on response to iontophoretically applied GABA and flurazepam. | Zhang H et al. | β | 1993 | β |
| Currents activated by GABA and their modulation by Zn2+ in cerebellar granule cells in culture. | KiliΔ G et al. | β | 1993 | β |
| Developmental changes in human gamma-aminobutyric acidA receptor subunit composition. | Brooks-Kayal AR et al. | β | 1993 | β |
| Differential affinity of dihydroimidazoquinoxalines and diimidazoquinazolines to the alpha 1 beta 2 gamma 2 and alpha 6 beta 2 gamma 2 subtypes of cloned GABAA receptors. | Im WB et al. | β | 1993 | β |
| Differential effects on GABAA receptor gamma 2-subunit messenger RNA by tolerance to and withdrawal from pentobarbital--an in situ hybridization study. | Tseng YT et al. | β | 1993 | β |
| Drugs acting on the intracellular signalling system. | Nomura Y et al. | β | 1993 | β |
| Dynorphin A(1-17) mediates midazolam antagonism of morphine antinociception in mice. | Rady JJ et al. | β | 1993 | β |
| Effects of cell signaling on the development of GABA receptors in chick retina neurons. | Shah BH et al. | β | 1993 | β |
| Electric shock convulsions in the rabbit and brain cortex GABAA receptor function. | Cupello A et al. | β | 1993 | β |
| Excluding linkage between panic disorder and the gamma-aminobutyric acid beta 1 receptor locus in five Icelandic pedigrees. | Schmidt SM et al. | β | 1993 | β |
| Expression and properties of recombinant alpha 1 beta 2 gamma 2 and alpha 5 beta 2 gamma 2 forms of the rat GABAA receptor. | Faure-Halley C et al. | β | 1993 | β |
| Expression of alpha 1, alpha 5, and gamma 2 GABAA receptor subunit mRNAs measured in situ in rat hippocampus and cortex following chronic flurazepam administration. | Tietz EI et al. | β | 1993 | β |
| Freeze-fracture immunocytochemical study of the expression of native and recombinant GABAA receptors. | Caruncho HJ et al. | β | 1993 | β |
| Functional heterogeneity of hippocampal GABAA receptors. | SchΓΆnrock B et al. | β | 1993 | β |
| GABAA/benzodiazepine receptor gamma 2 subunit gene expression in developing normal and mutant mouse cerebellum. | Luntz-Leybman V et al. | β | 1993 | β |
| GABA and potassium effects on corticospinal and primary afferent tracts of neonatal rat spinal dorsal columns. | Honmou O et al. | β | 1993 | β |
| GABAA receptor messenger RNA expression in the deep cerebellar nuclei of Purkinje cell degeneration mutants is maintained following the loss of innervating Purkinje neurons. | Gambarana C et al. | β | 1993 | β |
| GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital. | Amin J et al. | β | 1993 | β |
| GABAA receptor populations with novel subunit combinations and drug binding profiles identified in brain by alpha 5- and delta-subunit-specific immunopurification. | Mertens S et al. | β | 1993 | β |
| Immunochemical characterization of the beta 2 subunit of the GABAA receptor. | Machu TK et al. | β | 1993 | β |
| Involvement of a disulfide bond in the binding of flunitrazepam to the benzodiazepine receptor from bovine cerebral cortex. | Otero de Bengtsson MS et al. | β | 1993 | β |
| Lindane administration to the rat induces modifications in the regional cerebral binding of [3H]Muscimol, [3H]-flunitrazepam, and t-[35S]butylbicyclophosphorothionate: an autoradiographic study. | SolΓ C et al. | β | 1993 | β |
| Molecular determinants of general anesthetic action: role of GABAA receptor structure. | Lin LH et al. | β | 1993 | β |
| Molecular requirement for anticonvulsant activity in a series of thiazolo-1,4-benzodiazepine derivatives and comparison with classical benzodiazepines. | DeSarro GB et al. | β | 1993 | β |
| Mono N-aryl ethylenediamine and piperazine derivatives are GABAA receptor blockers: implications for psychiatry. | Squires RF et al. | β | 1993 | β |
| Neuron-specific expression of GABAA-receptor subtypes: differential association of the alpha 1- and alpha 3-subunits with serotonergic and GABAergic neurons. | Gao B et al. | β | 1993 | β |
| Pharmacological characteristics of GABAA responses in postnatal suprachiasmatic neurons in culture. | Kawahara F et al. | β | 1993 | β |
| Phosphorylation of the GABAA receptor by cAMP-dependent protein kinase and by protein kinase C: analysis of the substrate domain. | Browning MD et al. | β | 1993 | β |
| Postnatal development of diazepam-insensitive [3H]Ro 15-4513 binding sites. | Korpi ER et al. | β | 1993 | β |
| Radioligands for PET studies of central benzodiazepine receptors and PK (peripheral benzodiazepine) binding sites--current status. | Pike VW et al. | β | 1993 | β |
| Reduced [3H]flunitrazepam binding in cingulate cortex and hippocampus of postmortem schizophrenic brains: is selective loss of glutamatergic neurons associated with major psychoses? | Squires RF et al. | β | 1993 | β |
| Regional differences in the enhancement by GABA of [3H]zolpidem binding to omega 1 sites in rat brain membranes and sections. | Ruano D et al. | β | 1993 | β |
| Region-specific changes of GABAA receptors by tolerance to and dependence upon pentobarbital. | Tseng YT et al. | β | 1993 | β |
| Regulation of GABAA receptor in cerebellar granule cells in culture: differential involvement of kinase activities. | Robello M et al. | β | 1993 | β |
| Sequence and novel distribution of the chicken homologue of the mammalian gamma-aminobutyric acidA receptor gamma 1 subunit. | Glencorse TA et al. | β | 1993 | β |
| Stable expression of cloned rat GABAA receptor subunits in a human kidney cell line. | Hamilton BJ et al. | β | 1993 | β |
| Structure and function of cerebral GABAA and GABAB receptors. | Kuriyama K et al. | β | 1993 | β |
| Synaptic transmission and modulation in the olfactory bulb. | Trombley PQ et al. | β | 1993 | β |
| Synthesis of functional GABAA receptors in stable insect cell lines. | Joyce KA et al. | β | 1993 | β |
| The GABAA receptor channel mediated chloride ion translocation through the plasma membrane: new insights from 36Cl- ion flux measurements. | Kardos J | β | 1993 | β |
| The human neuroblastoma cell line, IMR-32 possesses a GABAA receptor lacking the benzodiazepine modulatory site. | Anderson SM et al. | β | 1993 | β |
| The influence of the gamma 2L subunit on the modulation of responses to GABAA receptor activation. | Horne AL et al. | β | 1993 | β |
| [3H]muscimol and [3H]flunitrazepam binding sites in the developing cerebellum of mice treated with methylazoxymethanol at different postnatal ages. | Bacon E et al. | β | 1992 | β |
| Aging related alterations in GABAA receptor subunit mRNA levels in Fischer rats. | Mhatre MC et al. | β | 1992 | β |
| A novel modulatory binding site for zinc on the GABAA receptor complex in cultured rat neurones. | Smart TG | β | 1992 | β |
| A single histidine in GABAA receptors is essential for benzodiazepine agonist binding. | Wieland HA et al. | β | 1992 | β |
| Bidirectional effect of beta-carboline agonists at the benzodiazepine-GABAA receptor chloride ionophore complex on GABA-stimulated 36Cl- uptake. | Malatynska E et al. | β | 1992 | β |
| Branched-chain amino acids increase the seizure threshold to picrotoxin in rats. | Skeie B et al. | β | 1992 | β |
| Cellular and molecular physiology of alcohol actions in the nervous system. | Weight FF | β | 1992 | β |
| Central-type benzodiazepines modulate GABAA receptor chloride channels in cultured pituitary melanotrophs. | Louiset E et al. | β | 1992 | β |
| Cerebellar and frontal cortical benzodiazepine receptors in human alcoholics and chronically alcohol-drinking rats. | Korpi ER et al. | β | 1992 | β |
| Characterization of endozepine-related peptides in the central nervous system and in peripheral tissues of the rat. | Rouet-Smih F et al. | β | 1992 | β |
| Characterization of two cerebellar binding sites of [3H]Ro 15-4513. | Uusi-Oukari M | β | 1992 | β |
| Co-expression of the alpha 1 and beta 2 subunit genes of the GABAA receptor in the magnocellular preoptic nucleus. | Zhang JH et al. | β | 1992 | β |
| Comparative molecular neuroanatomy of cloned GABAA receptor subunits in the rat CNS. | Persohn E et al. | β | 1992 | β |
| Developmental profile of polyadenylated and non-polyadenylated GABAA receptor subunit mRNAs. | Primus RJ et al. | β | 1992 | β |
| Differential effects of chronic ethanol administration on GABA(A) receptor alpha1 and alpha6 subunit mRNA levels in rat cerebellum. | Morrow AL et al. | β | 1992 | β |
| Differential expression of GABAA/benzodiazepine receptor beta 1, beta 2, and beta 3 subunit mRNAs in the developing mouse cerebellum. | Zdilar D et al. | β | 1992 | β |
| Differential expression of K+ channel mRNAs in the rat brain and down-regulation in the hippocampus following seizures. | Tsaur ML et al. | β | 1992 | β |
| Differential Localization of Two Alternatively Spliced GABAA Receptor gamma2-Subunit mRNAs in the Chick Brain. | Glencorse TA et al. | β | 1992 | β |
| Differential potentiation of GABAA receptor function by two stereoisomers of diimidazoquinazoline analogues. | Im HK et al. | β | 1992 | β |
| Differential subcellular distribution of the alpha 6 subunit versus the alpha 1 and beta 2/3 subunits of the GABAA/benzodiazepine receptor complex in granule cells of the cerebellar cortex. | Baude A et al. | β | 1992 | β |
| Direct modulation of GABAA receptor by intracellular ATP in dissociated nucleus tractus solitarii neurones of rat. | Shirasaki T et al. | β | 1992 | β |
| Distinct agonist- and antagonist-binding sites on the glycine receptor. | Vandenberg RJ et al. | β | 1992 | β |
| Distribution and characterization of endozepine-like immunoreactivity in the central nervous system of the frog Rana ridibunda. | Malagon M et al. | β | 1992 | β |
| Effect of thiol group modification on ion flux and ligand binding properties of the GABAA-benzodiazepine receptor chloride channel complex. | Allan AM et al. | β | 1992 | β |
| Effects of sedatives on GABA-mediated chloride flux into cerebral cortical microsacs prepared from emotional and non-emotional mice. | Mihic SJ et al. | β | 1992 | β |
| Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid. | Zaman SH et al. | β | 1992 | β |
| Ethanol potentiation of GABAA receptors requires phosphorylation of the alternatively spliced variant of the gamma 2 subunit. | Wafford KA et al. | β | 1992 | β |
| Expression of GABA and GABAA receptors by neurons of the subplate zone in developing primate occipital cortex: evidence for transient local circuits. | Meinecke DL et al. | β | 1992 | β |
| Expression of GABAA receptor polypeptides in clonal rat cell lines. | Kasckow JW et al. | β | 1992 | β |
| Expression of GABAA receptors in the vertebrate retina. | Brecha NC | β | 1992 | β |
| Expression patterns of gamma-aminobutyric acid type A receptor subunit mRNAs in primary cultures of granule neurons and astrocytes from neonatal rat cerebella. | Bovolin P et al. | β | 1992 | β |
| Fluctuations in responses to diazepam during the oestrous cycle in the mouse. | Carey MP et al. | β | 1992 | β |
| Functional expression of GABAA chloride channels and benzodiazepine binding sites in baculovirus infected insect cells. | Carter DB et al. | β | 1992 | β |
| Functional modulation of GABAA receptors by cAMP-dependent protein phosphorylation. | Moss SJ et al. | β | 1992 | β |
| Function of the alpha 1 beta 2 gamma 2S gamma-aminobutyric acid type A receptor is modulated by protein kinase C via multiple phosphorylation sites. | Kellenberger S et al. | β | 1992 | β |
| GABA agonists and antagonists. | Kerr DI et al. | β | 1992 | β |
| GABAA receptor function and regional analysis of subunit mRNAs in long-sleep and short-sleep mouse brain. | Zahniser NR et al. | β | 1992 | β |
| GABAA receptors control the excitability of neuronal populations. | Stelzer A | β | 1992 | β |
| GABAA receptor subunit messenger RNAs show differential expression during cortical development in the rat brain. | Araki T et al. | β | 1992 | β |
| GABAA receptor subunit mRNA levels are differentially influenced by chronic FG 7142 and diazepam exposure. | Primus RJ et al. | β | 1992 | β |
| Gamma-aminobutyric acidA receptor structure and function. | DeLorey TM et al. | β | 1992 | β |
| Gene expression in cells of the central nervous system. | Takahashi Y | β | 1992 | β |
| Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome. | Wilcox AS et al. | β | 1992 | β |
| Influences of gender, gonadectomy, and estrous cycle on GABA/BZ receptors and benzodiazepine responses in rats. | Wilson MA | β | 1992 | β |
| Intracellular regulation of GABAA-receptor function. | Stelzer A | β | 1992 | β |
| In vivo binding of [11C]Ro15-4513 in human brain measured with PET. | Inoue O et al. | β | 1992 | β |
| In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole. | Ashton D et al. | β | 1992 | β |
| Kinetic properties and regulation of GABAA receptor channels. | MacDonald RL et al. | β | 1992 | β |
| Localization of GABAA-receptor gamma 2-subunit mRNA-containing neurons in the rat central nervous system. | Araki T et al. | β | 1992 | β |
| Molecular basis of pharmacological heterogeneity of GABAA receptors. | Sieghart W | β | 1992 | β |
| Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at gamma-aminobutyric acid type A receptor. | Puia G et al. | β | 1992 | β |
| m-Sulfonate benzene diazonium chloride: a powerful affinity label for the gamma-aminobutyric acid binding site from rat brain. | Bouchet MJ et al. | β | 1992 | β |
| Muscimol-induced reduction of GABAA receptor alpha 1-subunit mRNA in primary cultured cerebral cortical neurons. | Hirouchi M et al. | β | 1992 | β |
| Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance. | Majewska MD | β | 1992 | β |
| NMDA receptors: role in ethanol withdrawal seizures. | Hoffman PL et al. | β | 1992 | β |
| Ontogeny of GABAA/benzodiazepine receptor subunit mRNAs in the murine inferior olive: transient appearance of beta 3 subunit mRNA and [3H]muscimol binding sites. | Frostholm A et al. | β | 1992 | β |
| Penicillin-induced potentiation of glycine receptor-operated chloride current in rat ventro-medial hypothalamic neurones. | Tokutomi N et al. | β | 1992 | β |
| Pharmacological and Electrophysiological Properties of Recombinant GABAA Receptors Comprising the alpha3, beta1 and gamma2 Subunits. | Knoflach F et al. | β | 1992 | β |
| Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels. | Sigel E et al. | β | 1992 | β |
| Postnatal ontogenesis of neurons containing GABAA alpha 1 subunit mRNA in the rat forebrain. | Zhang JH et al. | β | 1992 | β |
| Preparation of antibodies to beta subunits of gamma-aminobutyric acidA receptors. | Endo S et al. | β | 1992 | β |
| Quantification of naturally occurring benzodiazepine-like substances in human breast milk. | Dencker SJ et al. | β | 1992 | β |
| Quantitative immunoprecipitation studies with anti-gamma-aminobutyric acidA receptor gamma 2 1-15 Cys antibodies. | Duggan MJ et al. | β | 1992 | β |
| Receptors for L-glutamate and GABA in the nervous system of an insect (Periplaneta americana). | Sattelle DB | β | 1992 | β |
| Region-specific expression of GABAA receptor alpha 3 and alpha 4 subunits mRNAs in the rat brain. | Araki T et al. | β | 1992 | β |
| Regulation of flunitrazepam binding in the dorsal horn of the spinal cord by adrenalectomy and corticosteroids. | GonzΓ‘lez SL et al. | β | 1992 | β |
| Selective potentiation of GABA-mediated Cl- current by lanthanum ion in subtypes of cloned GABAA receptors. | Im MS et al. | β | 1992 | β |
| Stable expression of mammalian type A gamma-aminobutyric acid receptors in mouse cells: demonstration of functional assembly of benzodiazepine-responsive sites. | Hadingham KL et al. | β | 1992 | β |
| Strain comparisons and developmental profile of the delta subunit of the murine GABAA receptor. | Wang JB et al. | β | 1992 | β |
| Substrate specificity of diazepam-insensitive cerebellar [3H]Ro 15-4513 binding sites. | Korpi ER et al. | β | 1992 | β |
| The pharmacology of recombinant GABAA receptors containing bovine alpha 1, beta 1, gamma 2L sub-units stably transfected into mouse fibroblast L-cells. | Horne AL et al. | β | 1992 | β |
| The roles of serine and threonine sidechains in ion channels: a modelling study. | Sansom MS | β | 1992 | β |
| The third gamma subunit of the gamma-aminobutyric acid type A receptor family. | Herb A et al. | β | 1992 | β |
| The Ξ±<sub>1</sub>,Ξ±<sub>2</sub>, and Ξ±<sub>3</sub> Subunits of GABA<sub>A</sub> Receptors: Comparison in Seizure-Prone and -Resistant Mice and during Development. | Wang JB et al. | β | 1992 | β |
| Agonist-dependent internalization of gamma-aminobutyric acidA/benzodiazepine receptors in chick cortical neurons. | Tehrani MH et al. | β | 1991 | β |
| Allosteric actions of central nervous system depressants including anesthetics on subtypes of the inhibitory gamma-aminobutyric acidA receptor-chloride channel complex. | Olsen RW et al. | β | 1991 | β |
| Analysis of early events in acetylcholine receptor assembly. | Paulson HL et al. | β | 1991 | β |
| A novel gamma subunit of the GABAA receptor identified using the polymerase chain reaction. | Wilson-Shaw D et al. | β | 1991 | β |
| A review of evidence for GABergic predominance/glutamatergic deficit as a common etiological factor in both schizophrenia and affective psychoses: more support for a continuum hypothesis of "functional" psychosis. | Squires RF et al. | β | 1991 | β |
| A study of 3H-PK 11,195 binding to "peripheral-type" benzodiazepine receptors on human lymphocytes. Evidence of decreased binding in hepatic encephalopathy. | Ferrero P et al. | β | 1991 | β |
| Benzodiazepines do not potentiate GABA responses in neonatal hippocampal neurons. | Rovira C et al. | β | 1991 | β |
| Cellular distribution of L-glutamate decarboxylase (GAD) and gamma-aminobutyric acidA (GABAA) receptor mRNAs in the retina. | Brecha NC et al. | β | 1991 | β |
| Central-type benzodiazepines inhibit release of alpha-melanocyte-stimulating hormone from the rat hypothalamus. | Blasquez C et al. | β | 1991 | β |
| Characterization of recombinant GABAA receptors produced in transfected cells from murine alpha 1, beta 1, and gamma 2 subunit cDNAs. | Moss SJ et al. | β | 1991 | β |
| Chronic flurazepam differentially regulates a behavioral effect of GABA agonists. | Ramsey VA et al. | β | 1991 | β |
| Cloning of a glycine receptor subtype expressed in rat brain and spinal cord during a specific period of neuronal development. | Akagi H et al. | β | 1991 | β |
| Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina. | Cutting GR et al. | β | 1991 | β |
| [Comparative biochemical systems]. | Schoffeniels E | β | 1991 | β |
| 'Crosstalk': a pivotal role for protein kinase C in modulating relationships between signal transduction pathways. | Houslay MD | β | 1991 | β |
| Decreased GABAA receptor subunit mRNA concentrations following chronic lorazepam administration. | Kang I et al. | β | 1991 | β |
| Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor. | Wagner K et al. | β | 1991 | β |
| Diazepam binding inhibitor (DBI): a peptide with multiple biological actions. | Costa E et al. | β | 1991 | β |
| Diazepam enhances intrasynaptosomal free calcium concentrations. | Martin JV et al. | β | 1991 | β |
| Differential expression of GABAA receptor alpha-subunits in rat brain during development. | McKernan RM et al. | β | 1991 | β |
| Differential expression of two forms of GABAA receptor gamma 2-subunit in mice. | Wang JB et al. | β | 1991 | β |
| Differential ontogenesis of type I and II benzodiazepine receptors in mouse cerebellum. | Bacon E et al. | β | 1991 | β |
| Differential responses of expressed recombinant human gamma-aminobutyric acidA receptors to neurosteroids. | Lan NC et al. | β | 1991 | β |
| Different postnatal development profiles of neurons containing distinct GABAA receptor beta subunit mRNAs (beta 1, beta 2, and beta 3) in the rat forebrain. | Zhang JH et al. | β | 1991 | β |
| Distribution of GABAA-receptor alpha 1 subunit gene expression in the rat forebrain. | Zhang JH et al. | β | 1991 | β |
| Distribution of the GABAA receptor alpha 1- and gamma 2-subunit mRNAs in chick brain. | Glencorse TA et al. | β | 1991 | β |
| Ethanol interactions at the gamma-aminobutyric acid receptor complex. | Ticku MK | β | 1991 | β |
| Ethanol sensitivity of the GABAA receptor expressed in Xenopus oocytes requires 8 amino acids contained in the gamma 2L subunit. | Wafford KA et al. | β | 1991 | β |
| Expression and Developmental Regulation of a GABAA Receptor in Cultured Murine Cells of the Oligodendrocyte Lineage. | Von Blankenfeld G et al. | β | 1991 | β |
| Expression of GABAA/benzodiazepine receptor alpha 1-subunit mRNA and [3H]flunitrazepam binding sites during postnatal development of the mouse cerebellum. | Zdilar D et al. | β | 1991 | β |
| Expression patterns of GABAA receptor subtypes in developing hippocampal neurons. | Killisch I et al. | β | 1991 | β |
| Functional properties of strychnine-sensitive glycine receptors expressed in Xenopus oocytes injected with a single mRNA. | Akagi H et al. | β | 1991 | β |
| Function and pharmacology of multiple GABAA receptor subunits. | LΓΌddens H et al. | β | 1991 | β |
| GABA: an excitatory transmitter in early postnatal life. | Cherubini E et al. | β | 1991 | β |
| GABAA receptor complex function in frontal cortex membranes from control and neurological patients. | Lloyd GK et al. | β | 1991 | β |
| GABAA receptor function and expression following chronic ethanol and barbiturate administration. | Morrow AL et al. | β | 1991 | β |
| GABAA receptors are differentially sensitive to zinc: dependence on subunit composition. | Smart TG et al. | β | 1991 | β |
| GABAA receptors display association of gamma 2-subunit with alpha 1- and beta 2/3-subunits. | Benke D et al. | β | 1991 | β |
| GABAA receptors in the retina of the cat: an immunohistochemical study of wholemounts, sections, and dissociated cells. | Hughes TE et al. | β | 1991 | β |
| GABAA receptor subtypes immunopurified from rat brain with alpha subunit-specific antibodies have unique pharmacological properties. | McKernan RM et al. | β | 1991 | β |
| GABA receptor mechanisms in the central nervous system. | Sivilotti L et al. | β | 1991 | β |
| Gamma-aminobutyric acid enhancement of potassium-stimulated release of [3H]norepinephrine by multiple mechanisms in rat cortical slices. | Peoples RW et al. | β | 1991 | β |
| gamma-Aminobutyric acid type A receptor point mutation increases the affinity of compounds for the benzodiazepine site. | Pritchett DB et al. | β | 1991 | β |
| Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing. | Kofuji P et al. | β | 1991 | β |
| Genetic mapping of the beta 1 GABA receptor gene to human chromosome 4, using a tetranucleotide repeat polymorphism. | Dean M et al. | β | 1991 | β |
| Identification and characterization of a pregnane steroid recognition site that is functionally coupled to an expressed GABAA receptor. | Lan NC et al. | β | 1991 | β |
| Identification of alpha 1-, alpha 2- and alpha 3-subunit isoforms of the GABAA-benzodiazepine receptor in the rat brain. | Buchstaller A et al. | β | 1991 | β |
| Immunochemical identification of the alpha 1- and alpha 3-subunits of the GABAA-receptor in rat brain. | Benke D et al. | β | 1991 | β |
| Immunohistochemical localization of the alpha 1, alpha 2 and alpha 3 subunit of the GABAA receptor in the rat brain. | Zimprich F et al. | β | 1991 | β |
| Independent cellular and ontogenetic expression of mRNAs encoding three alpha polypeptides of the rat GABAA receptor. | MacLennan AJ et al. | β | 1991 | β |
| Insights into the structure and function of GABA-benzodiazepine receptors: ion channels and psychiatry. | Zorumski CF et al. | β | 1991 | β |
| In situ hybridization histochemistry reveals a diversity of GABAA receptor subunit mRNAs in neurons of the rat spinal cord and dorsal root ganglia. | Persohn E et al. | β | 1991 | β |
| Inverse but not full benzodiazepine agonists modulate recombinant alpha 6 beta 2 gamma 2 GABAA receptors in transfected human embryonic kidney cells. | Kleingoor C et al. | β | 1991 | β |
| Involvement of the dorsal hippocampus in mediation of the antianxiety action of tandospirone, a 5-hydroxytryptamine1A agonistic anxiolytic. | Kataoka Y et al. | β | 1991 | β |
| Isolation of type I and type II GABAA-benzodiazepine receptors by immunoaffinity chromatography. | Zezula J et al. | β | 1991 | β |
| Is the anticonvulsant effect of substantia nigra infusion of gamma-vinyl-GABA (GVG) mediated by the GABAA receptor in rat pups? | Xu SG et al. | β | 1991 | β |
| Kinetic properties of the glycine receptor main- and sub-conductance states of mouse spinal cord neurones in culture. | Twyman RE et al. | β | 1991 | β |
| Localization and functional expression of alternatively spliced forms of the GABA(A) receptor gamma(2) subunit. | Sikela JM et al. | β | 1991 | β |
| Mammalian peripheral-type benzodiazepine receptor is homologous to CrtK protein of rhodobacter capsulatus, a photosynthetic bacterium. | Baker ME et al. | β | 1991 | β |
| Molecular cloning and transformation of cyclodiene resistance in Drosophila: an invertebrate gamma-aminobutyric acid subtype A receptor locus. | Ffrench-Constant RH et al. | β | 1991 | β |
| Molecular models for recognition and activation at the benzodiazepine receptor: a review. | Villar HO et al. | β | 1991 | β |
| More than one alpha variant may exist in a GABAA/benzodiazepine receptor complex. | LΓΌddens H et al. | β | 1991 | β |
| N-deglycosylation and immunological identification indicates the existence of beta-subunit isoforms of the rat GABAA receptor. | Buchstaller A et al. | β | 1991 | β |
| Occurrence of "natural" benzodiazepines. | Klotz U | β | 1991 | β |
| Paradoxical Modulation of Nociception in Mice by Barbiturate Agonism and Antagonism: Is a GABA Site Involved in Nociception? | Carmody J et al. | β | 1991 | β |
| Parametric in vivo imaging of benzodiazepine receptor distribution in human brain. | Frey KA et al. | β | 1991 | β |
| Peptide heterogeneity of GABAA/benzodiazepine receptors in bovine cerebral cortex and cerebellum. | Park D et al. | β | 1991 | β |
| Peptide subunits of gamma-aminobutyric acidA/benzodiazepine receptors from bovine cerebral cortex. | Park D et al. | β | 1991 | β |
| Peripheral-type benzodiazepine receptors in anxiety disorders. | Rocca P et al. | β | 1991 | β |
| Persistent elevation in GABAA receptor subunit mRNAs following social stress. | Kang I et al. | β | 1991 | β |
| Pharmacologically distinct sodium-dependent L-[3H]glutamate transport processes in rat brain. | Robinson MB et al. | β | 1991 | β |
| Pharmacologic profile of a new anxiolytic, DN-2327: effect of Ro15-1788 and interaction with diazepam in rodents. | Wada T et al. | β | 1991 | β |
| Pharmacology of insect GABA receptors. | Sattelle DB et al. | β | 1991 | β |
| Prenatal development of the intrinsic neurons of the rat neocortex: a comparative study of the distribution of GABA-immunoreactive cells and the GABAA receptor. | Cobas A et al. | β | 1991 | β |
| Purification of the gamma-aminobutyric acidA/benzodiazepine receptor complex by immunoaffinity chromatography. | Park D et al. | β | 1991 | β |
| Region-specific expression of messenger RNAs encoding GABAA receptor subunits in the developing rat brain. | Gambarana C et al. | β | 1991 | β |
| Region-specific expression of the mRNAs encoding beta subunits (beta 1, beta 2, and beta 3) of GABAA receptor in the rat brain. | Zhang JH et al. | β | 1991 | β |
| Regulation of 35S-TBPS binding by bicuculline is region specific in rat brain. | Peris J et al. | β | 1991 | β |
| Role of DBI in brain and its posttranslational processing products in normal and abnormal behavior. | Guidotti A | β | 1991 | β |
| Separation of alpha 1, alpha 2 and alpha 3 subunits of the GABAA-benzodiazepine receptor complex by immunoaffinity chromatography. | Zezula J et al. | β | 1991 | β |
| Sequence and regional distribution of the mRNA encoding the alpha 2 polypeptide of rat gamma-aminobutyric acidA receptors. | Khrestchatisky M et al. | β | 1991 | β |
| Sequence of a functional invertebrate GABAA receptor subunit which can form a chimeric receptor with a vertebrate alpha subunit. | Harvey RJ et al. | β | 1991 | β |
| Single channels activated by high concentrations of GABA in superior cervical ganglion neurones of the rat. | Newland CF et al. | β | 1991 | β |
| Stability of GABAA/benzodiazepine receptor alpha 1 subunit mRNA expression in reeler mouse cerebellar Purkinje cells during postnatal development. | Frostholm A et al. | β | 1991 | β |
| Synthetic and computer assisted analysis of the pharmacophore for agonists at benzodiazepine receptors. | Diaz-Arauzo H et al. | β | 1991 | β |
| The cDNA sequence and chromosomal location of the murine GABAA alpha 1 receptor gene. | Keir WJ et al. | β | 1991 | β |
| The chicken GABAA receptor alpha 1 subunit: cDNA sequence and localization of the corresponding mRNA. | Bateson AN et al. | β | 1991 | β |
| The GABAA receptor family in the mammalian brain. | Olsen RW et al. | β | 1991 | β |
| The gamma 3-subunit of the GABAA-receptor confers sensitivity to benzodiazepine receptor ligands. | Knoflach F et al. | β | 1991 | β |
| The molecular biology of addictive drugs. | Mackler SA et al. | β | 1991 | β |
| The role of diazepam binding inhibitor and its processing products at mitochondrial benzodiazepine receptors: regulation of steroid biosynthesis. | Papadopoulos V et al. | β | 1991 | β |
| Use of 3' untranslated sequences of human cDNAs for rapid chromosome assignment and conversion to STSs: implications for an expression map of the genome. | Wilcox AS et al. | β | 1991 | β |
| Another mechanism for creating diversity in gamma-aminobutyrate type A receptors: RNA splicing directs expression of two forms of gamma 2 phosphorylation site. | Whiting P et al. | β | 1990 | β |
| Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex. | Belelli D et al. | β | 1990 | β |
| A steroid recognition site is functionally coupled to an expressed GABA(A)-benzodiazepine receptor. | Lan NC et al. | β | 1990 | β |
| Barbiturates and the GABAA receptor complex. | Saunders PA et al. | β | 1990 | β |
| Binding of pregnenolone sulfate to rat brain membranes suggests multiple sites of steroid action at the GABAA receptor. | Majewska MD et al. | β | 1990 | β |
| Biochemical characterization of an isolated and functionally reconstituted gamma-aminobutyric acid/benzodiazepine receptor. | Bristow DR et al. | β | 1990 | β |
| Biochemical evidence for the existence of gamma-aminobutyrateA receptor iso-oligomers. | Duggan MJ et al. | β | 1990 | β |
| Brain alpha-bungarotoxin binding protein cDNAs and MAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily. | Schoepfer R et al. | β | 1990 | β |
| Cerebellar GABAA receptor selective for a behavioural alcohol antagonist. | LΓΌddens H et al. | β | 1990 | β |
| Chronic benzodiazepine antagonist treatment and its withdrawal upregulates components of GABA-benzodiazepine receptor ionophore complex in cerebral cortex of rat. | Kulkarni SK et al. | β | 1990 | β |
| Chronic ethanol and pentobarbital administration in the rat: effects on GABAA receptor function and expression in brain. | Morrow AL et al. | β | 1990 | β |
| Cloned GABA receptors are maintained in a stable cell line: allosteric and channel properties. | Moss SJ et al. | β | 1990 | β |
| Cyclic AMP-dependent protein kinase decreases GABAA receptor current in mouse spinal neurons. | Porter NM et al. | β | 1990 | β |
| DBI (diazepam binding inhibitor): the precursor of a family of endogenous modulators of GABAA receptor function. History, perspectives, and clinical implications. | Barbaccia ML et al. | β | 1990 | β |
| Decrease in the function of the gamma-aminobutyric acid-coupled chloride channel produced by the repeated administration of pentylenetetrazol to rats. | Corda MG et al. | β | 1990 | β |
| Developmental expression of GABA and subunits of the GABAA receptor complex in an inhibitory synaptic circuit in the rat cerebellum. | Meinecke DL et al. | β | 1990 | β |
| Developmental expression of the GABAA receptor alpha 1 subunit mRNA in the rat brain. | Gambarana C et al. | β | 1990 | β |
| Development of benzodiazepine and picrotoxin (t-butylbicyclophosphorothionate) binding sites in rat cerebellar granule cells in culture. | Squires RF et al. | β | 1990 | β |
| Differential benzodiazepine pharmacology of mammalian recombinant GABAA receptors. | von Blankenfeld G et al. | β | 1990 | β |
| Differential effect of zinc on the vertebrate GABAA-receptor complex. | Smart TG et al. | β | 1990 | β |
| Distribution of GABA-immunoreactive amacrine cell synapses in the inner plexiform layer of macaque monkey retina. | Koontz MA et al. | β | 1990 | β |
| Effects of continuous diazepam administration on GABAA subunit mRNA in rat brain. | Heninger C et al. | β | 1990 | β |
| Effects of GABAA receptor ligands on noradrenaline concentration and beta-adrenoceptor binding in mouse cerebral cortex. | Gettins D et al. | β | 1990 | β |
| Ethanol potentiates the GABAA-activated Cl- current in mouse hippocampal and cortical neurons. | Aguayo LG | β | 1990 | β |
| Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+. | Draguhn A et al. | β | 1990 | β |
| Functional expression and sites of gene transcription of a novel alpha subunit of the GABAA receptor in rat brain. | Malherbe P et al. | β | 1990 | β |
| Functional properties of recombinant rat GABAA receptors depend upon subunit composition. | Verdoorn TA et al. | β | 1990 | β |
| GABAA-receptor expressed from rat brain alpha- and beta-subunit cDNAs displays potentiation by benzodiazepine receptor ligands. | Malherbe P et al. | β | 1990 | β |
| GABAA-receptors: structural requirements and sites of gene expression in mammalian brain. | Mohler H et al. | β | 1990 | β |
| GABAergic and dopaminergic transmission in the rat cerebral cortex: effect of stress, anxiolytic and anxiogenic drugs. | Biggio G et al. | β | 1990 | β |
| GABA receptors in insects. | Lummis SC | β | 1990 | β |
| Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology. | Pritchett DB et al. | β | 1990 | β |
| Genetic differences in the ethanol sensitivity of GABAA receptors expressed in Xenopus oocytes. | Wafford KA et al. | β | 1990 | β |
| Identification of alpha 2- and alpha 3-subunits of the GABAA-benzodiazepine receptor complex purified from the brains of young rats. | Fuchs K et al. | β | 1990 | β |
| Identification of the gamma 2-subunit protein in native GABAA receptors in brain. | Benke D et al. | β | 1990 | β |
| Ligand autoradiographic receptor screening: receptor cDNA expression in replicas of transfected COS cells. | Rattray M et al. | β | 1990 | β |
| Ligand-gated ion channels. Homology and diversity. | Cockcroft VB et al. | β | 1990 | β |
| Ligand-gated ion channels in the brain: the amino acid receptor superfamily. | Betz H | β | 1990 | β |
| Localization of GABAA-receptor alpha 1 subunit mRNA-containing neurons in the lower brainstem of the rat. | Hironaka T et al. | β | 1990 | β |
| Messenger molecules in the cerebellum. | Ross CA et al. | β | 1990 | β |
| Modeling of agonist binding to the ligand-gated ion channel superfamily of receptors. | Cockcroft VB et al. | β | 1990 | β |
| Modulation and polytypic signaling in GABAergic transmission. | Schlichting JL | β | 1990 | β |
| Molecular and cellular mechanisms of GABA/benzodiazepine-receptor regulation: electrophysiological and biochemical studies. | Farrant M et al. | β | 1990 | β |
| Monoclonal antibodies recognizing the benzodiazepine receptor of chick embryo brain. | Yin HS et al. | β | 1990 | β |
| Neurosteroids act on recombinant human GABAA receptors. | Puia G et al. | β | 1990 | β |
| Novel GABAA receptor alpha subunit is expressed only in cerebellar granule cells. | Kato K | β | 1990 | β |
| Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells. | Krueger KE et al. | β | 1990 | β |
| Protein kinase C and cAMP-dependent protein kinase phosphorylate the beta subunit of the purified gamma-aminobutyric acid A receptor. | Browning MD et al. | β | 1990 | β |
| Purification of the 5-hydroxytryptamine 5-HT3 receptor from NCB20 cells. | McKernan RM et al. | β | 1990 | β |
| Reduction of reticulata neuronal activity by zolpidem and alpidem, two imidazopyridines with high affinity for type I benzodiazepine receptors. | Mereu G et al. | β | 1990 | β |
| Regulation of cell excitability. | Brown DA | β | 1990 | β |
| Relationship of GABAa receptor heterogeneity to regional differences in drug response. | Gallager DW et al. | β | 1990 | β |
| Sequence of the chicken GABAA receptor gamma 2-subunit cDNA. | Glencorse TA et al. | β | 1990 | β |
| Structural and functional characterization of the gamma 1 subunit of GABAA/benzodiazepine receptors. | Ymer S et al. | β | 1990 | β |
| Subcellular localization of GABAA/benzodiazepine receptor-like immunoreactivity in the superficial gray layer of the rat superior colliculus. | Pinard R et al. | β | 1990 | β |
| Subunit selectivity and epitope characterization of mAbs directed against the GABAA/benzodiazepine receptor. | Ewert M et al. | β | 1990 | β |
| Tansley Review No. 21 Plant ion channels: whole-cell and single channel studies. | Tester M | β | 1990 | β |
| Temperature-sensitive expression of all-Torpedo and Torpedo-rat hybrid AChR in mammalian muscle cells. | Paulson HL et al. | β | 1990 | β |
| The differential expression patterns of the mRNAs encoding beta subunits (beta 1, beta 2 and beta 3) of GABAA receptor in the olfactory bulb and its related areas in the rat brain. | Zhang JH et al. | β | 1990 | β |
| The GABAA/benzodiazepine receptor complex in rat brain neuronal cultures. Characterization by immunoprecipitation. | Vitorica J et al. | β | 1990 | β |
| The GABAA/benzodiazepine receptor: implications for the molecular basis of anxiety. | Breier A et al. | β | 1990 | β |
| The GABA-benzodiazepine interaction fifteen years later. | Haefely W | β | 1990 | β |
| The gamma 2 subunit is an integral component of the gamma-aminobutyric acidA receptor but the alpha 1 polypeptide is the principal site of the agonist benzodiazepine photoaffinity labeling reaction. | Stephenson FA et al. | β | 1990 | β |
| The inhibition of single N-methyl-D-aspartate-activated channels by zinc ions on cultured rat neurones. | Legendre P et al. | β | 1990 | β |
| The murine GABAA receptor delta-subunit gene: structure and assignment to human chromosome 1. | Sommer B et al. | β | 1990 | β |
| The pharmacological properties of the imidazobenzodiazepine, FG 8205, a novel partial agonist at the benzodiazepine receptor. | Tricklebank MD et al. | β | 1990 | β |
| The role of receptor subtype diversity in the CNS. | Schofield PR et al. | β | 1990 | β |
| Use of Xenopus oocytes for the functional expression of plasma membrane proteins. | Sigel E | β | 1990 | β |
| A novel alpha subunit in rat brain GABAA receptors. | Khrestchatisky M et al. | β | 1989 | β |
| Differences in the negative allosteric modulation of gamma-aminobutyric acid receptors elicited by 4'-chlorodiazepam and by a beta-carboline-3-carboxylate ester: a study with natural and reconstituted receptors. | Puia G et al. | β | 1989 | β |
| Differential distribution of GABAA receptor mRNAs in bovine cerebellum--localization of alpha 2 mRNA in Bergmann glia layer. | Wisden W et al. | β | 1989 | β |
| Functional coupling of GABAA receptors and benzodiazepine recognition site subtypes in the spinal cord of the rat. | Corda MG et al. | β | 1989 | β |
| GABAA receptor beta subunit heterogeneity: functional expression of cloned cDNAs. | Ymer S et al. | β | 1989 | β |
| Immobilized GABAA receptors and their ligand binding characteristics. | Im WB et al. | β | 1989 | β |
| Immunocytochemical localization of the GABAA/benzodiazepine receptor in the guinea pig cochlear nucleus: evidence for receptor localization heterogeneity. | Juiz JM et al. | β | 1989 | β |
| Mapping the benzodiazepine photoaffinity-labelling site with sequence-specific gamma-aminobutyric acidA-receptor antibodies. | Stephenson FA et al. | β | 1989 | β |
| Multiple GABAA receptor alpha subunit mRNAs revealed by developmental and regional expression in rat, chicken and human brain. | Montpied P et al. | β | 1989 | β |
| Multiplicity of GABAA--benzodiazepine receptors. | Sieghart W | β | 1989 | β |
| Pharmacological characterization and region-specific expression in brain of the beta 2- and beta 3-subunits of the rat GABAA receptor. | Lolait SJ et al. | β | 1989 | β |
| Photoaffinity labeling of [3H]flunitrazepam- and [3H]Ro15-4513-bound pellets in rat cerebral cortex and cerebellum. | Chiu TH et al. | β | 1989 | β |
| Relationship of agonist efficacy to changes in GABA sensitivity and anticonvulsant tolerance following chronic benzodiazepine ligand exposure. | Hernandez TD et al. | β | 1989 | β |
| Sequence and expression of a novel GABAA receptor alpha subunit. | Ymer S et al. | β | 1989 | β |
| Steroid and barbiturate modulation of the GABAa receptor. Possible mechanisms. | Schumacher M et al. | β | 1989 | β |
| The functional diversity of the neuronal nicotinic acetylcholine receptors is increased by a novel subunit: beta 4. | Duvoisin RM et al. | β | 1989 | β |
| The GABAA receptor: molecular biology reveals a complex picture. | Schofield PR | β | 1989 | β |
| The rat beta 1-subunit of the GABAA receptor forms a picrotoxin-sensitive anion channel open in the absence of GABA. | Sigel E et al. | β | 1989 | β |
| The structure of ion channels in membranes of excitable cells. | Unwin N | β | 1989 | β |
| Two novel GABAA receptor subunits exist in distinct neuronal subpopulations. | Shivers BD et al. | β | 1989 | β |
| Type I and type II GABAA-benzodiazepine receptors produced in transfected cells. | Pritchett DB et al. | β | 1989 | β |