The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor.
paper
Cited
Public
Unavailable
- Authors
- Kroslak, Thomas; Laforge, K Steven; Gianotti, Robert J; Ho, Ann; Nielsen, David A; Kreek, Mary Jeanne
- Year
- 2007
- Journal
- Journal of neurochemistry
- PMID
- 17877633
- DOI
- 10.1111/j.1471-4159.2007.04738.x
The most common single nucleotide polymorphism in the coding region of the human mu opioid receptor gene is the A118G variant, an adenine to guanine transition at nucleotide position 118 of the coding sequence of the gene. This polymorphism codes for an asparagine to aspartic acid substitution at amino acid 40 in the amino-terminus, thereby removing a potential extracellular glycosylation site. Using in vitro cellular expression assays, this variant has been reported to change binding of the endogenous agonist beta-endorphin and signaling of the receptor following binding of beta-endorphin. Three clinical studies report that A118G genotype affects opioid antagonist-mediated increases in cortisol levels. These studies demonstrate a functional role of this variant in responses to endogenous and exogenous opioids. To further characterize function, we expressed the prototype and variant receptors in two types of cells (human 293 embryonic kidney cells and Syrian hamster adenovirus-12-induced tumor cells). Stable expression of variant and prototype receptors was characterized by differences in levels of cell surface binding capacity (B(max)), forskolin-induced cAMP accumulation, as well as agonist-induced accumulation of cAMP (EC(50)) for several agonists, but not for beta-endorphin. In contrast, transiently expressed variant receptors showed only a minor difference in cell surface binding capacity compared to the prototype, and no differences in cAMP EC(50) values.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Genetic and Epigenetic Approaches to Opioid Use Disorder. | Ranadeva ND et al. | β | 2025 | β |
| Pharmacogenetic Approach to Tramadol Use in the Arab Population. | Kwon CH et al. | β | 2024 | β |
| A novel tetra-primer ARMS-PCR for genotyping of the OPRM1 gene rs1799971 variant associated with opioid use disorders. | Wijekumar PJ et al. | β | 2023 | β |
| Association of <i>OPRM1</i>, <i>MIR23B</i>, and <i>MIR107</i> genetic variability with acute pain, chronic pain and adverse effects after postoperative tramadol and paracetamol treatment in breast cancer. | Vidic Z et al. | β | 2023 | β |
| Contribution of the opioid system to depression and to the therapeutic effects of classical antidepressants and ketamine. | Adzic M et al. | β | 2023 | β |
| Genome-wide association study on pharmacological outcomes of musculoskeletal pain in UK Biobank. | Li S et al. | β | 2023 | β |
| Associations of the A118G OPRM1 polymorphism with sociotropy and interpersonal sensitivity. | Suzuki A et al. | β | 2022 | β |
| Pharmacogenetics of Addiction Therapy. | Graham DP et al. | β | 2022 | β |
| Sublingual buprenorphine/naloxone treatment is not affected by OPRM1 A118G and BDNF Va66Met polymorphisms, but alters the plasma beta-endorphin and BDNF levels in individuals with opioid use disorder. | Kaya-AkyΓΌzlΓΌ D et al. | β | 2022 | β |
| The opioid system in depression. | Jelen LA et al. | β | 2022 | β |
| Variation in the Mu-Opioid Receptor (OPRM1) and Offspring Sex Are Associated With Maternal Behavior in Rhesus Macaques (<i>Macaca mulatta</i>). | Wood EK et al. | β | 2022 | β |
| Association Between the A118G Polymorphism of the <i>OPRM1</i> Gene and Suicidal Depression in a Large Cohort of Outpatients with Depression. | Nobile B et al. | β | 2021 | β |
| Genetic Vulnerability to Opioid Addiction. | Reed B et al. | β | 2021 | β |
| Overview of Genetic Analysis of Human Opioid Receptors. | Spampinato SM | β | 2021 | β |
| Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons. | Halikere A et al. | β | 2020 | β |
| A novel theory on the predictive value of variation in the Ξ²-endorphin system on the risk and severity of PTSD. | Mac Gillavry DW et al. | β | 2020 | β |
| A Truncated Six Transmembrane Splice Variant MOR-1G Enhances Expression of the Full-Length Seven Transmembrane <i>ΞΌ-</i>Opioid Receptor through Heterodimerization. | Zhang T et al. | β | 2020 | β |
| Differential sensitivity of human neurons carrying ΞΌ opioid receptor (MOR) N40D variants in response to ethanol. | Scarnati MS et al. | β | 2020 | β |
| Mu-Opioid Receptor Polymorphism Moderates Sensitivity to Parental Behaviors During Characterization of Personality Traits. | Noto K et al. | β | 2020 | β |
| Murine model of OPRM1 A118G alters oxycodone self-administration and locomotor activation, but not conditioned place preference. | Collins D et al. | β | 2020 | β |
| Systematic review and meta-analysis of the moderating effect of rs1799971 in OPRM1, the mu-opioid receptor gene, on response to naltrexone treatment of alcohol use disorder. | Hartwell EE et al. | β | 2020 | β |
| The Role of Opiates in Social Pain and Suicidal Behavior. | Nobile B et al. | β | 2020 | β |
| A review of opioid addiction genetics. | Crist RC et al. | β | 2019 | β |
| Endogenous opioid system dysregulation in depression: implications for new therapeutic approaches. | PeciΓ±a M et al. | β | 2019 | β |
| Genetic study in patients operated dentally and anesthetized with articaine-epinephrine. | LΓ³pez-Valverde N et al. | β | 2019 | β |
| Molecular Imaging of Opioid and Dopamine Systems: Insights Into the Pharmacogenetics of Opioid Use Disorders. | Burns JA et al. | β | 2019 | β |
| Placebo effects and the molecular biological components involved. | Cai L et al. | β | 2019 | β |
| The influence of the OPRM1 (A118G) polymorphism on behavioral and neural correlates of aggression in healthy males. | Weidler C et al. | β | 2019 | β |
| Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons | Halikere A et al. | β | 2018 | β |
| Heroin-induced suppression of saccharin intake in OPRM1 A118G mice. | Freet CS et al. | β | 2018 | β |
| Neurobiology of Opioid Use Disorder and Comorbid Traumatic Brain Injury. | Kosten TR et al. | β | 2018 | β |
| Opioid receptors: drivers to addiction? | Darcq E et al. | β | 2018 | β |
| Oprm1 A112G, a single nucleotide polymorphism, alters expression of stress-responsive genes in multiple brain regions in male and female mice. | Collins D et al. | β | 2018 | β |
| OPRM1 influence on and effectiveness of an individualized treatment plan for prescription opioid use disorder patients. | Muriel J et al. | β | 2018 | β |
| Pharmacogenetics of Methadone Response. | Fonseca F et al. | β | 2018 | β |
| Touch-induced face conditioning is mediated by genetic variation in opioid but not oxytocin receptors. | Fu Y et al. | β | 2018 | β |
| ΞΌ opioid receptor, social behaviour and autism spectrum disorder: reward matters. | Pellissier LP et al. | β | 2018 | β |
| A cis-eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use. | Otto JM et al. | β | 2017 | β |
| Association of Variants of Arginine Vasopressin and ArginineΒ Vasopressin Receptor 1A With Severe AcetaminophenΒ Liver Injury. | Randesi M et al. | β | 2017 | β |
| Cannabinoid Receptor Type 1 and mu-Opioid Receptor Polymorphisms Are Associated With Cyclic Vomiting Syndrome. | Wasilewski A et al. | β | 2017 | β |
| Convergent Balancing Selection on the Mu-Opioid Receptor in Primates. | Sweeney CG et al. | β | 2017 | β |
| Genetic Variation of the Mu Opioid Receptor (OPRM1) and Dopamine D2 Receptor (DRD2) is Related to Smoking Differences in Patients with Schizophrenia but not Bipolar Disorder. | Hirasawa-Fujita M et al. | β | 2017 | β |
| Low ΞΌ-Opioid Receptor Status in Alcohol Dependence Identified by Combined Positron Emission Tomography and Post-Mortem Brain Analysis. | Hermann D et al. | β | 2017 | β |
| A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology. | Bernardi RE et al. | β | 2016 | β |
| Genetic variants associated with thermal pain sensitivity in a paediatric population. | Matic M et al. | β | 2016 | β |
| Mechanisms of the placebo effect in pain and psychiatric disorders. | Holmes RD et al. | β | 2016 | β |
| Morphine-induced antinociception and reward in "humanized" mice expressing the mu opioid receptor A118G polymorphism. | Henderson-Redmond AN et al. | β | 2016 | β |
| Nicotine-specific and non-specific effects of cigarette smoking on endogenous opioid mechanisms. | Nuechterlein EB et al. | β | 2016 | β |
| Pharmacogenomics for personalized pain medicine. | Ko TM et al. | β | 2016 | β |
| Translational Research on Nicotine Dependence. | Falcone M et al. | β | 2016 | β |
| Addiction pharmacogenetics: a systematic review of the genetic variation of the dopaminergic system. | Patriquin MA et al. | β | 2015 | β |
| A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice. | Bilbao A et al. | β | 2015 | β |
| Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review. | Nielsen LM et al. | β | 2015 | β |
| Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population. | FrancΓ¨s F et al. | β | 2015 | β |
| Association of OPRM1 A118G variant with risk of morphine-induced respiratory depression following spine fusion in adolescents. | Chidambaran V et al. | β | 2015 | β |
| Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human ΞΌ-opioid receptor (OPRM1). | Knapman A et al. | β | 2015 | β |
| Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1. | Hancock DB et al. | β | 2015 | β |
| Common single nucleotide variants underlying drug addiction: more than a decade of research. | BΓΌhler KM et al. | β | 2015 | β |
| Cortisol Stress Response in Men and Women Modulated Differentially by the Mu-Opioid Receptor Gene Polymorphism OPRM1 A118G. | Lovallo WR et al. | β | 2015 | β |
| Effects of the Mu opioid receptor polymorphism (OPRM1 A118G) on pain regulation, placebo effects and associated personality trait measures. | PeciΓ±a M et al. | β | 2015 | β |
| Functional mu opioid receptor polymorphism (OPRM1 A(118) G) associated with heroin use outcomes in Caucasian males: A pilot study. | Woodcock EA et al. | β | 2015 | β |
| Genetics and the placebo effect: the placebome. | Hall KT et al. | β | 2015 | β |
| Genotyping test with clinical factors: better management of acute postoperative pain? | Hajj A et al. | β | 2015 | β |
| Mouse model of the OPRM1 (A118G) polymorphism: differential heroin self-administration behavior compared with wild-type mice. | Zhang Y et al. | β | 2015 | β |
| Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism. | Robinson JE et al. | β | 2015 | β |
| Subjective response as a consideration in the pharmacogenetics of alcoholism treatment. | Roche DJ et al. | β | 2015 | β |
| Tissue-Specific Glycosylation at the Glycopeptide Level. | Medzihradszky KF et al. | β | 2015 | β |
| ΞΌ-Opioid Receptor Gene A118Β G Variants and Persistent Pain Symptoms Among Men and Women Experiencing Motor VehicleΒ Collision. | Linnstaedt SD et al. | β | 2015 | β |
| A heroin addiction severity-associated intronic single nucleotide polymorphism modulates alternative pre-mRNA splicing of the ΞΌ opioid receptor gene OPRM1 via hnRNPH interactions. | Xu J et al. | β | 2014 | β |
| Buprenorphine signalling is compromised at the N40D polymorphism of the human ΞΌ opioid receptor in vitro. | Knapman A et al. | β | 2014 | β |
| Epigenetic variation in the mu-opioid receptor gene in infants with neonatal abstinence syndrome. | Wachman EM et al. | β | 2014 | β |
| Genetics of opiate addiction. | Reed B et al. | β | 2014 | β |
| Genetics of Opioid Dependence: A Review of the Genetic Contribution to Opioid Dependence. | Mistry CJ et al. | β | 2014 | β |
| Higher frequency of C.3435 of the ABCB1 gene in patients with tramadol dependence disorder. | Enabah D et al. | β | 2014 | β |
| OPRM1 A118G gene variant and postoperative opioid requirement: a systematic review and meta-analysis. | Hwang IC et al. | β | 2014 | β |
| Pharmacogenetics of addiction therapy. | Nielsen DA et al. | β | 2014 | β |
| Pharmacogenetics of OPRM1. | Crist RC et al. | β | 2014 | β |
| Targeting opioid receptors with pharmacological chaperones. | PetΓ€jΓ€-Repo UE et al. | β | 2014 | β |
| A machine-learned knowledge discovery method for associating complex phenotypes with complex genotypes. Application to pain. | LΓΆtsch J et al. | β | 2013 | β |
| Analgesia and central side-effects: two separate dimensions of morphine response. | Droney JM et al. | β | 2013 | β |
| Association study of OPRM1 polymorphisms with Schizophrenia in Han Chinese population. | Ding S et al. | β | 2013 | β |
| Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside? | Mura E et al. | β | 2013 | β |
| Functional characteristics of the naked mole rat ΞΌ-opioid receptor. | Busch-Dienstfertig M et al. | β | 2013 | β |
| Genotyping the Mu-opioid receptor A118G polymorphism using the real-time amplification refractory mutation system: allele frequency distribution among Brazilians. | Daher M et al. | β | 2013 | β |
| Influence of mu-opioid receptor variant on morphine use and self-rated pain following abdominal hysterectomy. | Sia AT et al. | β | 2013 | β |
| Low frequency genetic variants in the ΞΌ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine. | Clarke TK et al. | β | 2013 | β |
| Mu-opioid receptor A118G polymorphism in healthy volunteers affects hypothalamic-pituitary-adrenal axis adrenocorticotropic hormone stress response to metyrapone. | Ducat E et al. | β | 2013 | β |
| Mu opioids and their receptors: evolution of a concept. | Pasternak GW et al. | β | 2013 | β |
| Peter Riederer "70th birthday" neurobiological foundations of modern addiction treatment. | Jacob C | β | 2013 | β |
| Prevention of chronic postoperative pain: cellular, molecular, and clinical insights for mechanism-based treatment approaches. | Deumens R et al. | β | 2013 | β |
| Recent developments in the study of opioid receptors. | Cox BM | β | 2013 | β |
| Regulation of ΞΌ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. | Williams JT et al. | β | 2013 | β |
| Β΅-opioid receptor gene variant OPRM1 118 A>G: a summary of its molecular and clinical consequences for pain. | Walter C et al. | β | 2013 | β |
| A common single nucleotide polymorphism A118G of theΒ ΞΌ opioid receptor alters its N-glycosylation and protein stability. | Huang P et al. | β | 2012 | β |
| Association of polymorphisms of the mu opioid receptor gene with the severity of HIV infection and response to HIV treatment. | Proudnikov D et al. | β | 2012 | β |
| Common and specific liability to addiction: approaches to association studies of opioid addiction. | Nielsen DA et al. | β | 2012 | β |
| Influence of the OPRM1 A118G polymorphism on alcohol-induced euphoria, risk for alcoholism and the clinical efficacy of naltrexone. | Setiawan E et al. | β | 2012 | β |
| Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics. | Kreek MJ et al. | β | 2012 | β |
| Pharmacogenetically driven treatments for alcoholism: are we there yet? | Arias AJ et al. | β | 2012 | β |
| Pharmacogenomic considerations in opioid analgesia. | Vuilleumier PH et al. | β | 2012 | β |
| The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction. | Burkett JP et al. | β | 2012 | β |
| The genetics of addiction-a translational perspective. | Agrawal A et al. | β | 2012 | β |
| The genetics of the opioid system and specific drug addictions. | Levran O et al. | β | 2012 | β |
| The promise of pharmacogenetics in labor analgesiaβ¦tantalizing, but not there yet. | Wong CA | β | 2012 | β |
| The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review. | Ray LA et al. | β | 2012 | β |
| Tobacco smoking produces greater striatal dopamine release in G-allele carriers with mu opioid receptor A118G polymorphism. | Domino EF et al. | β | 2012 | β |
| Translational genetic approaches to substance use disorders: bridging the gap between mice and humans. | Palmer AA et al. | β | 2012 | β |
| Variation in OPRM1 and risk of suicidal behavior in drug-dependent individuals. | Arias AJ et al. | β | 2012 | β |
| Child ΞΌ-opioid receptor gene variant influences parent-child relations. | Copeland WE et al. | β | 2011 | β |
| Evolving knowledge of opioid genetics in cancer pain. | Droney J et al. | β | 2011 | β |
| Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans. | Lee MR et al. | β | 2011 | β |
| Litter gender composition and sex affect maternal behavior and DNA methylation levels of the oprm1 gene in rat offspring. | Hao Y et al. | β | 2011 | β |
| Micro opioid receptor A118G polymorphism and post-operative pain: opioids' effects on heterozygous patients. | De Capraris A et al. | β | 2011 | β |
| Mu-opioid receptor (OPRM1) variation, oxytocin levels and maternal attachment in free-ranging rhesus macaques Macaca mulatta. | Higham JP et al. | β | 2011 | β |
| Opiates, overeating and obesity: a psychogenetic analysis. | Davis C et al. | β | 2011 | β |
| OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques. | Schwandt ML et al. | β | 2011 | β |
| Pharmacogenetic approaches to the treatment of alcohol addiction. | Heilig M et al. | β | 2011 | β |
| Pharmacogenomics of the human Β΅-opioid receptor. | Kasai S et al. | β | 2011 | β |
| Pharmacological consequence of the A118G ΞΌ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of CaΒ²βΊ channels in humanized mouse sensory neurons. | Mahmoud S et al. | β | 2011 | β |
| Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients. | Troisi A et al. | β | 2011 | β |
| Using the Phenogen website for 'in silico' analysis of morphine-induced analgesia: identifying candidate genes. | Hoffman PL et al. | β | 2011 | β |
| A118G polymorphism of OPRM1 gene is associated with schizophrenia. | SerΓ½ O et al. | β | 2010 | β |
| A polymorphism in exon 2 of the delta-opioid receptor affects nociception in response to specific agonists and antagonists in mice selectively bred for high and low analgesia. | Sacharczuk M et al. | β | 2010 | β |
| Drug-induced and genetic alterations in stress-responsive systems: Implications for specific addictive diseases. | Zhou Y et al. | β | 2010 | β |
| Mouse strain differences in locomotor, sensitisation and rewarding effect of heroin; association with alterations in MOP-r activation and dopamine transporter binding. | Bailey A et al. | β | 2010 | β |
| Neuropathic and chronic pain stimuli downregulate central mu-opioid and dopaminergic transmission. | Niikura K et al. | β | 2010 | β |
| OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models. | Mague SD et al. | β | 2010 | β |
| Overview and historical perspective of four papers presented on research related to the endogenous opioid system. | Kreek MJ | β | 2010 | β |
| Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. | Yuferov V et al. | β | 2010 | β |
| Single-nucleotide polymorphism (A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction. | Deb I et al. | β | 2010 | β |
| The interpersonal dimension of borderline personality disorder: toward a neuropeptide model. | Stanley B et al. | β | 2010 | β |
| The ΞΌ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs. | Fortin JP et al. | β | 2010 | β |
| A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain. | Oertel BG et al. | β | 2009 | β |
| Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery. | Fukuda K et al. | β | 2009 | β |
| Bidirectional translational research: Progress in understanding addictive diseases. | Kreek MJ et al. | β | 2009 | β |
| Current evidence for a modulation of low back pain by human genetic variants. | Tegeder I et al. | β | 2009 | β |
| Dopamine for "wanting" and opioids for "liking": a comparison of obese adults with and without binge eating. | Davis CA et al. | β | 2009 | β |
| Ethnicity and OPRM variant independently predict pain perception and patient-controlled analgesia usage for post-operative pain. | Tan EC et al. | β | 2009 | β |
| Meta-analysis of the relevance of the OPRM1 118A>G genetic variant for pain treatment. | Walter C et al. | β | 2009 | β |
| Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior. | Mague SD et al. | β | 2009 | β |
| Pain-related effects of trait anger expression: neural substrates and the role of endogenous opioid mechanisms. | Bruehl S et al. | β | 2009 | β |
| Polymorphism of the micro-opioid receptor gene (OPRM1 118A>G) affects fentanyl-induced analgesia during anesthesia and recovery. | Wu WD et al. | β | 2009 | β |
| The evolution of vertebrate opioid receptors. | Stevens CW | β | 2009 | β |
| The G allele of SNP E1/A118G at the mu-opioid receptor gene locus shows genomic evidence of recent positive selection. | Pang GS et al. | β | 2009 | β |
| The potential of pharmacogenomics to treat drug addiction. | Haile CN et al. | β | 2009 | β |
| Variation in the mu-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection. | Way BM et al. | β | 2009 | β |
| Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype. | Hayashida M et al. | β | 2008 | β |
| Endogenous opiates and behavior: 2007. | Bodnar RJ | β | 2008 | β |
| Genetic variability of the mu-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women. | Landau R et al. | β | 2008 | β |
| Human expression variation in the mu-opioid receptor is paralleled in rhesus macaque. | Vallender EJ et al. | β | 2008 | β |
| Pharmacogenetic treatments for drug addiction: alcohol and opiates. | Haile CN et al. | β | 2008 | β |
| Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability. | Chen GL et al. | β | 2008 | β |
| Role of a functional human gene polymorphism in stress responsivity and addictions. | Kreek MJ | β | 2008 | β |
| The mu opioid receptor A118G gene polymorphism moderates effects of trait anger-out on acute pain sensitivity. | Bruehl S et al. | β | 2008 | β |
| Variable response to opioid treatment: any genetic predictors within sight? | Skorpen F et al. | β | 2008 | β |
| Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates. | Barr CS et al. | β | 2008 | β |