Do centrally administered neuropeptides access cognate receptors?: an analysis in the central corticotropin-releasing factor system.
paper
Cited
Public
Unavailable
- Authors
- Bittencourt, J C; Sawchenko, P E
- Year
- 2000
- Journal
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- PMID
- 10648719
- DOI
- 10.1523/JNEUROSCI.20-03-01142.2000
- PMCID
- PMC6774165
To determine the extent to which centrally administered corticotropin-releasing factor (CRF) activates neurons that express CRF receptors (CRF-Rs), we followed the kinetics and distribution (relative to those of CRF-Rs) of Fos induction seen in response to intracerebroventricular (icv) injection of the peptide (1-10 microg). CRF provoked widespread Fos expression: its strength was dose-related, it peaked at 2 hr after injection, and it was antagonized in a dose-dependent manner by coinjection of CRF-R antagonists. The activation pattern closely mimicked the distribution of CRF-R1 mRNA, in including widespread Fos induction throughout the cortical mantle, in cell groups involved in sensory information processing, and in the cerebellum and several of its major afferents and targets. Dual labeling revealed extensive correspondence of CRF-stimulated Fos-immunoreactivity (Fos-ir) and CRF-R1 mRNA at these and other loci. Unique sites of CRF-R2 expression were relatively unresponsive to CRF but were more so after icv administration of urocortin (UCN), a new mammalian CRF-related peptide. Both CRF and UCN elicited activational responses in cell groups that are involved in central autonomic control but that express neither CRF-R, including the central amygdaloid and paraventricular hypothalamic nuclei, and brainstem catecholaminergic cell groups. The results support an ability of CRF-related peptides in the ventricular system to access receptor-expressing cells directly but leave open questions as to the basis for the recruitment of central autonomic structures, many of which have been identified as stress-related sites of CRF action.
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| Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders. | Linthorst AC | β | 2005 | β |
| Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond to stress. | Tanaka M et al. | β | 2005 | β |
| Neuropeptides in anxiety modulation. | Landgraf R | β | 2005 | β |
| Pituitary adenylate cyclase-activating polypeptide (PACAP) mimics neuroendocrine and behavioral manifestations of stress: Evidence for PKA-mediated expression of the corticotropin-releasing hormone (CRH) gene. | Agarwal A et al. | β | 2005 | β |
| Restraint stress delays solid gastric emptying via a central CRF and peripheral sympathetic neuron in rats. | Nakade Y et al. | β | 2005 | β |
| Tissue plasminogen activator in the bed nucleus of stria terminalis regulates acoustic startle. | Matys T et al. | β | 2005 | β |
| Anatomic and functional topography of the dorsal raphe nucleus. | Abrams JK et al. | β | 2004 | β |
| Anticipatory cues differentially provoke in vivo peptidergic and monoaminergic release at the medial prefrontal cortex. | Merali Z et al. | β | 2004 | β |
| Anxiolytic activity of the MGLU2/3 receptor agonist LY354740 on the elevated plus maze is associated with the suppression of stress-induced c-Fos in the hippocampus and increases in c-Fos induction in several other stress-sensitive brain regions. | Linden AM et al. | β | 2004 | β |
| Both corticotropin-releasing factor receptor type 1 and type 2 are involved in stress-induced inhibition of food intake in rats. | Sekino A et al. | β | 2004 | β |
| Cardiovascular effects of long-term central and peripheral administration of urocortin, corticotropin-releasing factor, and adrenocorticotropin in sheep. | Weisinger RS et al. | β | 2004 | β |
| Central structures necessary and sufficient for ingestive and glycemic responses to Urocortin I administration. | Daniels D et al. | β | 2004 | β |
| c-fos and CRF receptor gene transcription in the brain of acetic acid-induced somato-visceral pain in rats. | Sinniger V et al. | β | 2004 | β |
| Colocalization of urocortin and neuronal nitric oxide synthase in the hypothalamus and Edinger-Westphal nucleus of the rat. | Spina MG et al. | β | 2004 | β |
| Corticosterone facilitates retention of contextually conditioned fear and increases CRH mRNA expression in the amygdala. | Thompson BL et al. | β | 2004 | β |
| Corticotropin releasing factor enhances survival of cultured GABAergic cerebellar neurons after exposure to a neurotoxin. | Madtes P et al. | β | 2004 | β |
| Corticotropin-releasing factor inhibits maternal aggression in mice. | Gammie SC et al. | β | 2004 | β |
| Corticotropin-releasing hormone directly activates noradrenergic neurons of the locus ceruleus recorded in vitro. | Jedema HP et al. | β | 2004 | β |
| CRF and CRF receptors: role in stress responsivity and other behaviors. | Bale TL et al. | β | 2004 | β |
| Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus. | Day HE et al. | β | 2004 | β |
| Differential regulation of behavioral, genomic, and neuroendocrine responses by CRF infusions in rats. | Campbell BM et al. | β | 2004 | β |
| Hippocampal corticotropin releasing hormone: pre- and postsynaptic location and release by stress. | Chen Y et al. | β | 2004 | β |
| Lesions of the Edinger-Westphal nucleus in C57BL/6J mice disrupt ethanol-induced hypothermia and ethanol consumption. | Bachtell RK et al. | β | 2004 | β |
| Neuroendocrinology of nutritional infertility. | Wade GN et al. | β | 2004 | β |
| Neuronal activity and CRF receptor gene transcription in the brains of rats with colitis. | Porcher C et al. | β | 2004 | β |
| The effects of repeated intra-amygdala CRF injections on rat behavior and HPA axis function after stress. | Daniels WM et al. | β | 2004 | β |
| The influence of 17beta-oestradiol on corticotrophin-releasing hormone induced suppression of luteinising hormone pulses and the role of CRH in hypoglycaemic stress-induced suppression of pulsatile LH secretion in the female rat. | Cates PS et al. | β | 2004 | β |
| Tissue plasminogen activator promotes the effects of corticotropin-releasing factor on the amygdala and anxiety-like behavior. | Matys T et al. | β | 2004 | β |
| Urocortins and the regulation of gastrointestinal motor function and visceral pain. | Martinez V et al. | β | 2004 | β |
| Altered serotonergic neurotransmission but normal hypothalamic-pituitary-adrenocortical axis activity in mice chronically treated with the corticotropin-releasing hormone receptor type 1 antagonist NBI 30775. | Oshima A et al. | β | 2003 | β |
| CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors. | Kinzig KP et al. | β | 2003 | β |
| Cytoarchitecture and efferent projections of the nucleus incertus of the rat. | Olucha-Bordonau FE et al. | β | 2003 | β |
| Fear and power-dominance motivation: proposed contributions of peptide hormones present in cerebrospinal fluid and plasma. | Sewards TV et al. | β | 2003 | β |
| Fos induction in the rat deep cerebellar and vestibular nuclei following central administration of colchicine: a qualitative and quantitative time-course study. | Pirnik Z et al. | β | 2003 | β |
| Human urocortin II, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat. | Inoue K et al. | β | 2003 | β |
| Intraperitoneal corticotropin-releasing factor and urocortin induce Fos expression in brain and spinal autonomic nuclei and long lasting stimulation of colonic motility in rats. | Maillot C et al. | β | 2003 | β |
| Monoaminergic activity in subregions of raphΓ© nuclei elicited by prior stress and the neuropeptide corticotropin-releasing factor. | Summers CH et al. | β | 2003 | β |
| Neural regulation of blood pressure by leptin and the related peptides. | Matsumura K et al. | β | 2003 | β |
| Neuroendocrine pharmacology of stress. | Carrasco GA et al. | β | 2003 | β |
| Reduced attention in mice overproducing corticotropin-releasing hormone. | van Gaalen MM et al. | β | 2003 | β |
| Regulation of corticotropin-releasing factor (CRF) type-1 receptor gene expression by CRF in the hypothalamus. | Konishi S et al. | β | 2003 | β |
| Role of corticotropin releasing factor (CRF) receptors 1 and 2 in CRF-potentiated acoustic startle in mice. | Risbrough VB et al. | β | 2003 | β |
| The effect of urocortin on ingestive behaviours and brain Fos immunoreactivity in mice. | Sinnayah P et al. | β | 2003 | β |
| Corticotropin-releasing hormone (CRH) downregulates the function of its receptor (CRF1) and induces CRF1 expression in hippocampal and cortical regions of the immature rat brain. | Brunson KL et al. | β | 2002 | β |
| Corticotropin-releasing hormone receptor type 1-deficiency enhances hippocampal serotonergic neurotransmission: an in vivo microdialysis study in mutant mice. | PeΓ±alva RG et al. | β | 2002 | β |
| Distinct brain vascular cell types manifest inducible cyclooxygenase expression as a function of the strength and nature of immune insults. | Schiltz JC et al. | β | 2002 | β |
| Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake. | Grill HJ et al. | β | 2002 | β |
| Forced swim stress activates rat hippocampal serotonergic neurotransmission involving a corticotropin-releasing hormone receptor-dependent mechanism. | Linthorst AC et al. | β | 2002 | β |
| GRK3 regulation during CRF- and urocortin-induced CRF1 receptor desensitization. | Dautzenberg FM et al. | β | 2002 | β |
| Interaction of CRH and energy balance in the modulation of brain stimulation reward. | Fulton S et al. | β | 2002 | β |
| Intracisternal urocortin inhibits vagally stimulated gastric motility in rats: role of CRF(2). | Chen CY et al. | β | 2002 | β |
| Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation. | Roozendaal B et al. | β | 2002 | β |
| Molecular targets in the treatment of anxiety. | Kent JM et al. | β | 2002 | β |
| On the role of corticotropin-releasing hormone receptors in anxiety and depression. | Reul JM et al. | β | 2002 | β |
| Strain differences in urocortin expression in the Edinger-Westphal nucleus and its relation to alcohol-induced hypothermia. | Bachtell RK et al. | β | 2002 | β |
| The CRF peptide family and their receptors: yet more partners discovered. | Dautzenberg FM et al. | β | 2002 | β |
| The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness. | Kinzig KP et al. | β | 2002 | β |
| The neuroanatomical axis for control of energy balance. | Grill HJ et al. | β | 2002 | β |
| The role of corticotropin-releasing factor in the median raphe nucleus in relapse to alcohol. | LΓͺ AD et al. | β | 2002 | β |
| Animal models of CRH excess and CRH receptor deficiency display altered adaptations to stress. | Coste SC et al. | β | 2001 | β |
| Basic organization of projections from the oval and fusiform nuclei of the bed nuclei of the stria terminalis in adult rat brain. | Dong HW et al. | β | 2001 | β |
| Cardiovascular actions of CRH and urocortin: an update. | Parkes DG et al. | β | 2001 | β |
| Centrally administered corticotropin-releasing hormone and peripheral injections of strychnine hydrochloride potentiate the acoustic startle response in preweanling rats. | Weber M et al. | β | 2001 | β |
| Connections of the nucleus incertus. | Goto M et al. | β | 2001 | β |
| Corticotropin-releasing factor (CRF) or CRF binding-protein ligand inhibitor administration suppresses food intake in mice and elevates body temperature in rats. | Heinrichs SC et al. | β | 2001 | β |
| Corticotropin-releasing hormone and its receptors; an evaluation at the transcription level in vivo. | Drolet G et al. | β | 2001 | β |
| Effects of central and peripheral urocortin on fed and fasted gastroduodenal motor activity in conscious rats. | Kihara N et al. | β | 2001 | β |
| Interaction between the cholinergic system and CRH in the modulation of spatial discrimination learning in mice. | Steckler T et al. | β | 2001 | β |
| Microinfusion of a nitric oxide donor in discrete brain regions activates the hypothalamic-pituitary-adrenal axis. | Seo DO et al. | β | 2001 | β |
| Mouse models of altered CRH-binding protein expression. | Seasholtz AF et al. | β | 2001 | β |
| Rapid changes in monoamine levels following administration of corticotropin-releasing factor or corticosterone are localized in the dorsomedial hypothalamus. | Lowry CA et al. | β | 2001 | β |
| Role of brain arachidonic acid cascade on central CRF1 receptor-mediated activation of sympatho-adrenomedullary outflow in rats. | Yokotani K et al. | β | 2001 | β |
| The molecular neurobiology of stress--evidence from genetic and epigenetic models. | Steckler T | β | 2001 | β |
| Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. | Reyes TM et al. | β | 2001 | β |
| Cellular localization of corticotropin releasing factor receptors in the adult mouse cerebellum. | Bishop GA et al. | β | 2000 | β |
| Corticotropin-releasing factor increases in vitro firing rates of serotonergic neurons in the rat dorsal raphe nucleus: evidence for activation of a topographically organized mesolimbocortical serotonergic system. | Lowry CA et al. | β | 2000 | β |
| Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse. | Van Pett K et al. | β | 2000 | β |
| Long-term effects on feeding and body weight after stimulation of forebrain or hindbrain CRH receptors with urocortin. | Grill HJ et al. | β | 2000 | β |
| Modulation of urocortin-induced hypophagia and weight loss by corticotropin-releasing factor receptor 1 deficiency in mice. | Bradbury MJ et al. | β | 2000 | β |
| Paradoxical activational effects of a corticotropin-releasing factor-binding protein "ligand inhibitor" in rat brain. | Chan RK et al. | β | 2000 | β |
| The neurobiology of urocortin. | Skelton KH et al. | β | 2000 | β |