Rnd family genes are differentially regulated by 3,4-methylenedioxymethamphetamine and cocaine acute treatment in mice brain.
- Authors
- Marie-Claire, Cynthia; Salzmann, Julie; David, Alexandre; Courtin, Cindie; Canestrelli, Corinne; Noble, Florence
- Year
- 2007
- Journal
- Brain research
- PMID
- 17196187
- DOI
- 10.1016/j.brainres.2006.11.065
Drugs of abuse induce alterations in cytoskeletal and cytoskeleton associated genes in several brain areas. We have previously shown that acute MDMA regulates the mRNA level of Rnd3, a Rho GTPase involved in actin cytoskeleton regulation, in mice striatum. In this study we investigated the effects of single administration of cocaine, another psychostimulant with a slightly different mechanism of action, on the mRNA levels of the three members of the Rnd genes family (Rnd1, Rnd2 and Rnd3). Mice were treated with either MDMA (9 mg/kg) or cocaine (20 mg/jg) and brain samples (i.e. hippocampus, striatum and prefrontal cortex) were processed for quantitative real-time PCR assay 1, 2, 4 and 6 h after the injections. The expression level of Rnd2 was differentially affected depending on the drug, brain area and time point after injection. Interestingly the two drugs up-regulate Rnd3 gene expression in the three structures tested with some differences in the timing. The effects of MDMA on Rnd3 appear earlier in the hippocampus as compared to cocaine, while it is the opposite in the prefrontal cortex. However, in the dorsal striatum, the two drugs induce an early and significant up-regulation of Rnd3 expression that is longer-lasting in the case of MDMA. In the case of cocaine contrarily to what was observed with MDMA, this modulation could not be blocked with the ERK activation inhibitor SL327 suggesting that the two drugs lead to the same effect on Rnd3 by two distinct pathways.
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| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | — | 2017 | → |
| Function and regulation of Rnd proteins in cortical projection neuron migration. | Azzarelli R et al. | — | 2015 | → |
| Pathophysiological Functions of Rnd3/RhoE. | Jie W et al. | — | 2015 | → |
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| Active and passive MDMA ('ecstasy') intake induces differential transcriptional changes in the mouse brain. | Fernàndez-Castillo N et al. | — | 2012 | → |
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| Rnd proteins: multifunctional regulators of the cytoskeleton and cell cycle progression. | Riou P et al. | — | 2010 | → |
| Cocaine regulates ezrin-radixin-moesin proteins and RhoA signaling in the nucleus accumbens. | Kim WY et al. | — | 2009 | → |
| Transcriptomic configuration of mouse brain induced by adolescent exposure to 3,4-methylenedioxymethamphetamine. | Eun JW et al. | — | 2009 | → |
| Characteristics of dual specificity phosphatases mRNA regulation by 3,4-methylenedioxymethamphetamine acute treatment in mice striatum. | Marie-Claire C et al. | — | 2008 | → |