Evidence for enhanced neurobehavioral vulnerability to nicotine during periadolescence in rats.
paper
Cited
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- Authors
- Adriani, Walter; Spijker, Sabine; Deroche-Gamonet, VΓ©ronique; Laviola, Giovanni; Le Moal, Michel; Smit, August B; Piazza, Pier Vincenzo
- Year
- 2003
- Journal
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- PMID
- 12805310
- DOI
- 10.1523/JNEUROSCI.23-11-04712.2003
- PMCID
- PMC6740776
Epidemiological studies indicate that there is an increased likelihood for the development of nicotine addiction when cigarette smoking starts early during adolescence. These observations suggest that adolescence could be a "critical" ontogenetic period, during which drugs of abuse have distinct effects responsible for the development of dependence later in life. We compared the long-term behavioral and molecular effects of repeated nicotine treatment during either periadolescence or postadolescence in rats. It was found that exposure to nicotine during periadolescence, but not a similar exposure in the postadolescent period, increased the intravenous self-administration of nicotine and the expression of distinct subunits of the ligand-gated acetylcholine receptor in adult animals. Both these changes indicated an increased sensitivity to the addictive properties of nicotine. In conclusion, adolescence seems to be a critical developmental period, characterized by enhanced neurobehavioral vulnerability to nicotine.
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| Paradoxical Ventral Tegmental Area GABA Signaling Drives Enhanced Morphine Reward After Adolescent Nicotine. | Wittenberg RE et al. | β | 2026 | β |
| Adolescent nicotine exposure affects later-life nicotine reward and withdrawal in mice. | Buzzi B et al. | β | 2025 | β |
| Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks. | Reynolds LM et al. | β | 2025 | β |
| Evaluation of the role of omega-3 fatty acids in nicotine-induced neurotoxicity in pregnant Wistar rats and their pups. | Omole JG et al. | β | 2025 | β |
| Long-term effects of adolescent versus adult nicotine self-administration on cholinergic modulation of dopamine in the nucleus accumbens core. | Iacino MC et al. | β | 2025 | β |
| Paradoxical ventral tegmental area GABA signaling drives enhanced morphine reward after adolescent nicotine | Wittenberg RE et al. | β | 2025 | β |
| Factors influencing JUUL e-cigarette nicotine vapour-induced reward, withdrawal, pharmacokinetics and brain connectivity in rats: sex matters. | Frie JA et al. | β | 2024 | β |
| Nicotine and Cardiovascular Health: When Poison is Addictive - a WHF Policy Brief. | Dorotheo EU et al. | β | 2024 | β |
| Consequences of adolescent drug use. | Steinfeld MR et al. | β | 2023 | β |
| Susceptibility to arecoline in male C57BL/6Β J mice correlates with age factor. | Pi M et al. | β | 2023 | β |
| Adolescence as a sensitive period for neurotoxicity: Lifespan developmental effects of methylmercury. | Kendricks DR et al. | β | 2022 | β |
| Adolescent nicotine administration impacts working memory and reversal learning but not cognitive flexibility. | Rodefer JS et al. | β | 2022 | β |
| Biological determinants impact the neurovascular toxicity of nicotine and tobacco smoke: A pharmacokinetic and pharmacodynamics perspective. | Archie SR et al. | β | 2022 | β |
| Development of anxiety-like behaviors during adolescence: Persistent effects of adolescent morphine exposure in male rats. | Khani F et al. | β | 2022 | β |
| DNA Epigenetics in Addiction Susceptibility. | Kaplan G et al. | β | 2022 | β |
| Impact of acute nicotine exposure on monoaminergic systems in adolescent and adult male and female rats. | Eddins D et al. | β | 2022 | β |
| Unique effects of nicotine across the lifespan. | Ren M et al. | β | 2022 | β |
| Adolescent nicotine and footshock exposure augments adult nicotine self-administration and drug-seeking without affecting baseline anxiety-like behaviour or stress responsivity in male rats. | Renda B et al. | β | 2021 | β |
| Effects of adolescent substance use disorders on central cholinergic function. | Hauser SR et al. | β | 2021 | β |
| Multidimensional Intersection of Nicotine, Gene Expression, and Behavior. | Sherafat Y et al. | β | 2021 | β |
| Multifactorial Etiology of Adolescent Nicotine Addiction: A Review of the Neurobiology of Nicotine Addiction and Its Implications for Smoking Cessation Pharmacotherapy. | Mahajan SD et al. | β | 2021 | β |
| Repeated nicotine exposure increases the intracellular interaction between ERK-mGluR5 in the nucleus accumbens more in adult than adolescent rats. | Yang JH et al. | β | 2021 | β |
| The reinforcement threshold and elasticity of demand for nicotine in an adolescent rat model of depression. | Smethells JR et al. | β | 2021 | β |
| Adolescence versus adulthood: Differences in basal mesolimbic and nigrostriatal dopamine transmission and response to drugs of abuse. | Corongiu S et al. | β | 2020 | β |
| Adolescent neurodevelopment and substance use: Receptor expression and behavioral consequences. | Thorpe HHA et al. | β | 2020 | β |
| High-dose adolescent nicotine exposure permits spontaneous nicotine self-administration in adult male rats. | Renda B et al. | β | 2020 | β |
| Unique, long-term effects of nicotine on adolescent brain. | Leslie FM | β | 2020 | β |
| Nicotine Gateway Effects on Adolescent Substance Use. | Ren M et al. | β | 2019 | β |
| Adolescent Nicotine Exposure Alters GABA<sub>A</sub> Receptor Signaling in the Ventral Tegmental Area and Increases Adult Ethanol Self-Administration. | Thomas AM et al. | β | 2018 | β |
| Early adolescent nicotine exposure affects later-life hippocampal mu-opioid receptors activity and morphine reward but not physical dependence in male mice. | Kota D et al. | β | 2018 | β |
| Early onset cigarette smokers exhibit greater P300 reactivity to smoking-related stimuli and report greater craving. | Mashhoon Y et al. | β | 2018 | β |
| Effect of e-cigarette advertisement exposure on intention to use e-cigarettes in adolescents. | Stroup AM et al. | β | 2018 | β |
| Adolescent chronic escalating morphine administration induces long lasting changes in tolerance and dependence to morphine in rats. | Salmanzadeh H et al. | β | 2017 | β |
| Animal Research on Nicotine Reduction: Current Evidence and Research Gaps. | Smith TT et al. | β | 2017 | β |
| Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products. | England LJ et al. | β | 2017 | β |
| Differences between adolescents and adults in the acute effects of PCP and ketamine and in sensitization following intermittent administration. | Rocha A et al. | β | 2017 | β |
| Re-exposure to nicotine-associated context from adolescence enhances alcohol intake in adulthood. | Zipori D et al. | β | 2017 | β |
| Unravelling the Link Between Prenatal Stress, Dopamine and Substance Use Disorder. | Pastor V et al. | β | 2017 | β |
| Adolescent alcohol exposure decreased sensitivity to nicotine in adult Wistar rats. | Boutros N et al. | β | 2016 | β |
| Adolescent Maturational Transitions in the Prefrontal Cortex and Dopamine Signaling as a Risk Factor for the Development of Obesity and High Fat/High Sugar Diet Induced Cognitive Deficits. | Reichelt AC | β | 2016 | β |
| Cigarette smoke exposure during adolescence but not adulthood induces anxiety-like behavior and locomotor stimulation in rats during withdrawal. | de la PeΓ±a JB et al. | β | 2016 | β |
| Consequences of adolescent use of alcohol and other drugs: Studies using rodent models. | Spear LP | β | 2016 | β |
| Early adolescent nicotine exposure affects later-life cocaine reward in mice. | Alajaji M et al. | β | 2016 | β |
| Impact of prenatal nicotine on the structure of midbrain dopamine regions in the rat. | Omelchenko N et al. | β | 2016 | β |
| N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats. | Okamura AM et al. | β | 2016 | β |
| Nicotine, adolescence, and stress: A review of how stress can modulate the negative consequences of adolescent nicotine abuse. | Holliday E et al. | β | 2016 | β |
| Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use. | Melroy-Greif WE et al. | β | 2016 | β |
| Role of Central Amygdala Neuronal Ensembles in Incubation of Nicotine Craving. | Funk D et al. | β | 2016 | β |
| Adolescent nicotine induces persisting changes in development of neural connectivity. | Smith RF et al. | β | 2015 | β |
| Behavioral mechanisms underlying nicotine reinforcement. | Rupprecht LE et al. | β | 2015 | β |
| Cholinergic modulation of dopamine pathways through nicotinic acetylcholine receptors. | de Kloet SF et al. | β | 2015 | β |
| Cigarette smoke exposure during adolescence enhances sensitivity to the rewarding effects of nicotine in adulthood, even after a long period of abstinence. | de la PeΓ±a JB et al. | β | 2015 | β |
| Effects of adolescent treatment with nicotine, harmane, or norharmane in male Sprague-Dawley rats. | Goodwin AK et al. | β | 2015 | β |
| Effects of chronic cocaine treatment during adolescence in Lewis and Fischer-344 rats: Novel location recognition impairment and changes in synaptic plasticity in adulthood. | Fole A et al. | β | 2015 | β |
| Individual differences in the behavioral effects of nicotine: A review of the preclinical animal literature. | Falco AM et al. | β | 2015 | β |
| Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse. | Korpi ER et al. | β | 2015 | β |
| Nicotine and the adolescent brain. | Yuan M et al. | β | 2015 | β |
| Paradoxical effects of injection stress and nicotine exposure experienced during adolescence on learning in a serial multiple choice (SMC) task in adult female rats. | Renaud SM et al. | β | 2015 | β |
| Regulation of Ξ±4Ξ²2Ξ±5 nicotinic acetylcholinergic receptors in rat cerebral cortex in early and late adolescence: Sex differences in response to chronic nicotine. | Hoegberg BG et al. | β | 2015 | β |
| Adolescent alcohol exposure and persistence of adolescent-typical phenotypes into adulthood: a mini-review. | Spear LP et al. | β | 2014 | β |
| Adolescent brain maturation and smoking: what we know and where we're headed. | Lydon DM et al. | β | 2014 | β |
| Adolescent nicotine or cigarette smoke exposure changes subsequent response to nicotine conditioned place preference and self-administration. | de la PeΓ±a JB et al. | β | 2014 | β |
| Anxiety status affects nicotine- and baclofen-induced locomotor activity, anxiety, and single-trial conditioned place preference in male adolescent rats. | Falco AM et al. | β | 2014 | β |
| Basal activity level in mice predicts the initial and sensitized locomotor response to nicotine only in high responders. | Bernardi RE et al. | β | 2014 | β |
| Developmental alterations in locomotor and anxiety-like behavior as a function of D1 and D2 mRNA expression. | Falco AM et al. | β | 2014 | β |
| Ethanol conditioned place preference and alterations in ΞFosB following adolescent nicotine administration differ in rats exhibiting high or low behavioral reactivity to a novel environment. | Philpot RM et al. | β | 2014 | β |
| Exposure to nicotine enhances its subsequent self-administration: contribution of nicotine-associated contextual stimuli. | Neugebauer NM et al. | β | 2014 | β |
| Hippocampal Y2 receptor-mediated mossy fiber plasticity is implicated in nicotine abstinence-related social anxiety-like behavior in an outbred rat model of the novelty-seeking phenotype. | Aydin C et al. | β | 2014 | β |
| Juvenile play experience does not affect nicotine sensitization and voluntary consumption of nicotine in adult rats. | Himmler BT et al. | β | 2014 | β |
| Low-dose nicotine self-administration is reduced in adult male rats naΓ―ve to high doses of nicotine: implications for nicotine product standards. | Smith TT et al. | β | 2014 | β |
| Molecules and circuits involved in nicotine addiction: The many faces of smoking. | Picciotto MR et al. | β | 2014 | β |
| Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: sex-selective effects on cerebrocortical serotonergic function. | Slotkin TA et al. | β | 2014 | β |
| Nicotine exposure during adolescence: cognitive performance and brain gene expression in adult heterozygous reeler mice. | Romano E et al. | β | 2014 | β |
| Adolescence is a period of development characterized by short- and long-term vulnerability to the rewarding effects of nicotine and reduced sensitivity to the anorectic effects of this drug. | Natividad LA et al. | β | 2013 | β |
| Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use, and compulsive smoking. | Cohen A et al. | β | 2013 | β |
| A role for synaptic plasticity in the adolescent development of executive function. | Selemon LD | β | 2013 | β |
| Cross-species approaches to pathological gambling: a review targeting sex differences, adolescent vulnerability and ecological validity of research tools. | van den Bos R et al. | β | 2013 | β |
| Passive Response to Stress in Adolescent Female and Adult Male Mice after Intermittent Nicotine Exposure in Adolescence. | Thanos P et al. | β | 2013 | β |
| Potential substrates for nicotine and alcohol interactions: a focus on the mesocorticolimbic dopamine system. | Doyon WM et al. | β | 2013 | β |
| Sex differences in adult cognitive deficits after adolescent nicotine exposure in rats. | Pickens LR et al. | β | 2013 | β |
| The effect of previous exposure to nicotine on nicotine place preference. | Pastor V et al. | β | 2013 | β |
| Adolescent exposure to nicotine results in reinforcement enhancement but does not affect adult responding in rats. | Weaver MT et al. | β | 2012 | β |
| Adolescent nicotine exposure transiently increases high-affinity nicotinic receptors and modulates inhibitory synaptic transmission in rat medial prefrontal cortex. | Counotte DS et al. | β | 2012 | β |
| Comparison of nicotine oral consumption and baseline anxiety measures in adolescent and adult C57BL/6J and C3H/Ibg mice. | Wilking JA et al. | β | 2012 | β |
| Developmental effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning. | Portugal GS et al. | β | 2012 | β |
| Impact of tobacco regulation on animal research: new perspectives and opportunities. | Donny EC et al. | β | 2012 | β |
| Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. | Hartz SM et al. | β | 2012 | β |
| Long-term effects of juvenile nicotine exposure on abstinence-related social anxiety-like behavior and amygdalar cannabinoid receptor 1 (CB1R) mRNA expression in the novelty-seeking phenotype. | Aydin C et al. | β | 2012 | β |
| Nicotine exposure during adolescence alters the rules for prefrontal cortical synaptic plasticity during adulthood. | Goriounova NA et al. | β | 2012 | β |
| Previous exposure to nicotine enhances the incentive motivational effects of amphetamine via nicotine-associated contextual stimuli. | Cortright JJ et al. | β | 2012 | β |
| Short- and long-term consequences of nicotine exposure during adolescence for prefrontal cortex neuronal network function. | Goriounova NA et al. | β | 2012 | β |
| Age-dependent effects of initial exposure to nicotine on serotonin neurons. | Bang SJ et al. | β | 2011 | β |
| A social operational model of urban adolescents' tobacco and substance use: a mediational analysis. | Mason MJ et al. | β | 2011 | β |
| Critical age windows for neurodevelopmental psychiatric disorders: evidence from animal models. | Marco EM et al. | β | 2011 | β |
| Development of the motivational system during adolescence, and its sensitivity to disruption by nicotine. | Counotte DS et al. | β | 2011 | β |
| Drugs as instruments from a developmental child and adolescent psychiatric perspective. | Banaschewski T et al. | β | 2011 | β |
| Exploring behavioral and molecular mechanisms of nicotine reward in adolescent mice. | Kota D et al. | β | 2011 | β |
| Heightened nicotinic regulation of auditory cortex during adolescence. | Kawai HD et al. | β | 2011 | β |
| Individual differences in oral nicotine intake in rats. | Nesil T et al. | β | 2011 | β |
| Nicotine alters limbic function in adolescent rat by a 5-HT1A receptor mechanism. | Dao JM et al. | β | 2011 | β |
| Threshold of adulthood for the onset of nicotine self-administration in male and female rats. | Levin ED et al. | β | 2011 | β |
| An animal model of social instability stress in adolescence and risk for drugs of abuse. | McCormick CM | β | 2010 | β |
| Changes in molecular composition of rat medial prefrontal cortex synapses during adolescent development. | Counotte DS et al. | β | 2010 | β |
| Chronic nicotine exposure produces lateralized, age-dependent dendritic remodeling in the rodent basolateral amygdala. | Bergstrom HC et al. | β | 2010 | β |
| Nicotine withdrawal increases threat-induced anxiety but not fear: neuroadaptation in human addiction. | Hogle JM et al. | β | 2010 | β |
| Predicting the life-time benefit of school-based smoking prevention programmes. | Jit M et al. | β | 2010 | β |
| Age-dependent effects of low-dose nicotine treatment on cocaine-induced behavioral plasticity in rats. | McQuown SC et al. | β | 2009 | β |
| Age dependent nicotinic influences over dopamine neuron synaptic plasticity. | Placzek AN et al. | β | 2009 | β |
| Amphetamine- and nicotine-induced cross-sensitization in adolescent rats persists until adulthood. | Santos GC et al. | β | 2009 | β |
| A psychobiological framework of the substrates that mediate nicotine use during adolescence. | O'Dell LE | β | 2009 | β |
| Behavioral consequences of repeated nicotine during adolescence in alcohol-preferring AA and alcohol-avoiding ANA rats. | Kemppainen H et al. | β | 2009 | β |
| Effects of nicotine in experimental animals and humans: an update on addictive properties. | Le Foll B et al. | β | 2009 | β |
| Enhanced nicotine reward in adulthood after exposure to nicotine during early adolescence in mice. | Kota D et al. | β | 2009 | β |
| Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes. | Baker TB et al. | β | 2009 | β |
| Individual differences in responses to nicotine: tracking changes from adolescence to adulthood. | Li M et al. | β | 2009 | β |
| Long-lasting cognitive deficits resulting from adolescent nicotine exposure in rats. | Counotte DS et al. | β | 2009 | β |
| Modeling risk factors for nicotine and other drug abuse in the preclinical laboratory. | Carroll ME et al. | β | 2009 | β |
| Neurobiology of the development of motivated behaviors in adolescence: a window into a neural systems model. | Ernst M et al. | β | 2009 | β |
| Nicotine exposure during adolescence induces a depression-like state in adulthood. | IΓ±iguez SD et al. | β | 2009 | β |
| Sex and ovarian hormones influence vulnerability and motivation for nicotine during adolescence in rats. | Lynch WJ | β | 2009 | β |
| Stealing a march in the 21st century: accelerating progress in the 100-year war against tobacco addiction in the United States. | Fiore MC et al. | β | 2009 | β |
| Synergistic interaction between nicotine and social rewards in adolescent male rats. | Thiel KJ et al. | β | 2009 | β |
| The dynamic effects of nicotine on the developing brain. | Dwyer JB et al. | β | 2009 | β |
| A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. | Weiss RB et al. | β | 2008 | β |
| Adolescent exposure to nicotine alters the aversive effects of cocaine in adult rats. | Hutchison MA et al. | β | 2008 | β |
| Adult and periadolescent rats differ in expression of nicotinic cholinergic receptor subtypes and in the response of these subtypes to chronic nicotine exposure. | Doura MB et al. | β | 2008 | β |
| Anxiety-like behavior during nicotine withdrawal predict subsequent nicotine consumption in adolescent C57BL/6 mice. | ManhΓ£es AC et al. | β | 2008 | β |
| Contextual renewal of nicotine seeking in rats and its suppression by the cannabinoid-1 receptor antagonist Rimonabant (SR141716A). | Diergaarde L et al. | β | 2008 | β |
| Continuous nicotine administration produces selective, age-dependent structural alteration of pyramidal neurons from prelimbic cortex. | Bergstrom HC et al. | β | 2008 | β |
| Differential sensitivity to the effects of nicotine and bupropion in adolescent and adult male OF1 mice during social interaction tests. | GΓ³mez MC et al. | β | 2008 | β |
| Effect of forced chronic oral nicotine exposure on intravenous self-administration and rewarding properties of acute nicotine. | TammimΓ€ki A et al. | β | 2008 | β |
| If nicotine is a developmental neurotoxicant in animal studies, dare we recommend nicotine replacement therapy in pregnant women and adolescents? | Slotkin TA | β | 2008 | β |
| Influence of neuronal nicotinic receptors over nicotine addiction and withdrawal. | De Biasi M et al. | β | 2008 | β |
| Low dose domoic acid in neonatal rats abolishes nicotine induced conditioned place preference during late adolescence. | Burt MA et al. | β | 2008 | β |
| Neurobiological processes in adolescent addictive disorders. | Schepis TS et al. | β | 2008 | β |
| Nicotine self-administration, extinction responding and reinstatement in adolescent and adult male rats: evidence against a biological vulnerability to nicotine addiction during adolescence. | Shram MJ et al. | β | 2008 | β |
| Periadolescent male but not female rats have higher motor activity in response to morphine than do adult rats. | White DA et al. | β | 2008 | β |
| The dendritically targeted protein Dendrin is induced by acute nicotine in cortical regions of adolescent rat brain. | Schochet TL et al. | β | 2008 | β |
| Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake. | Perry JL et al. | β | 2007 | β |
| Adolescent nicotine exposure produces less affective measures of withdrawal relative to adult nicotine exposure in male rats. | O'Dell LE et al. | β | 2007 | β |
| Adolescent reward system perseveration due to nicotine: studies with methylphenidate. | Nolley EP et al. | β | 2007 | β |
| Adolescent vs. adult-onset nicotine self-administration in male rats: duration of effect and differential nicotinic receptor correlates. | Levin ED et al. | β | 2007 | β |
| Age, sex and early environment contribute to individual differences in nicotine/acetaldehyde-induced behavioral and endocrine responses in rats. | Park MK et al. | β | 2007 | β |
| Assessment of adolescent neurotoxicity: rationale and methodological considerations. | Spear LP | β | 2007 | β |
| A unique role for striatal serotonergic systems in the withdrawal from adolescent nicotine administration. | Slotkin TA et al. | β | 2007 | β |
| Developmental regulation of nicotinic acetylcholine receptors within midbrain dopamine neurons. | Azam L et al. | β | 2007 | β |
| Guidelines on nicotine dose selection for in vivo research. | Matta SG et al. | β | 2007 | β |
| HPA function in adolescence: role of sex hormones in its regulation and the enduring consequences of exposure to stressors. | McCormick CM et al. | β | 2007 | β |
| Immediate and long-term behavioral effects of a single nicotine injection in adolescent and adult rats. | Brielmaier JM et al. | β | 2007 | β |
| Increased rewarding properties of morphine in perinatally protein-malnourished rats. | Valdomero A et al. | β | 2007 | β |
| Locomotor activity to nicotine and Fos immunoreactivity in the paraventricular nucleus of the hypothalamus in adolescent socially-stressed rats. | McCormick CM et al. | β | 2007 | β |
| Low dose nicotine treatment during early adolescence increases subsequent cocaine reward. | McQuown SC et al. | β | 2007 | β |
| Nicotine causes age-dependent changes in gene expression in the adolescent female rat brain. | Polesskaya OO et al. | β | 2007 | β |
| Nicotine dependence and reward differ between adolescent and adult male mice. | Kota D et al. | β | 2007 | β |
| Nicotine increases FosB expression within a subset of reward- and memory-related brain regions during both peri- and post-adolescence. | Soderstrom K et al. | β | 2007 | β |
| Periadolescent nicotine exposure produces sensitization to reinforcement by diazepam in the rat. | James-Walke NL et al. | β | 2007 | β |
| Perinatal nicotine exposure eliminates peak in nicotinic acetylcholine receptor response in adolescent rats. | Britton AF et al. | β | 2007 | β |
| Role of acetaldehyde in tobacco smoke addiction. | Talhout R et al. | β | 2007 | β |
| Secondhand smoke and nicotine exposure: a brief review. | Okoli CT et al. | β | 2007 | β |
| Smoking impacts on prefrontal attentional network function in young adult brains. | Musso F et al. | β | 2007 | β |
| Age-related smoking progression among adolescents in China. | Sun W et al. | β | 2006 | β |
| Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction. | O'Dell LE et al. | β | 2006 | β |
| Gestational nicotine-induced changes in adolescent neuronal activity. | Park MK et al. | β | 2006 | β |
| In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats. | Abou-Donia MB et al. | β | 2006 | β |
| Nicotine as a typical drug of abuse in experimental animals and humans. | Le Foll B et al. | β | 2006 | β |
| Periadolescent and adult rats respond differently in tests measuring the rewarding and aversive effects of nicotine. | Shram MJ et al. | β | 2006 | β |
| Perinatal protein malnutrition enhances rewarding cocaine properties in adult rats. | Valdomero A et al. | β | 2006 | β |
| Preexposure during or following adolescence differently affects nicotine-rewarding properties in adult rats. | Adriani W et al. | β | 2006 | β |
| Prenatal nicotine exposure alters the responses to subsequent nicotine administration and withdrawal in adolescence: Serotonin receptors and cell signaling. | Slotkin TA et al. | β | 2006 | β |
| Relapse to smoking. | Piasecki TM | β | 2006 | β |
| Spontaneously hypertensive rats do not predict symptoms of attention-deficit hyperactivity disorder. | van den Bergh FS et al. | β | 2006 | β |
| Acetaldehyde enhances acquisition of nicotine self-administration in adolescent rats. | Belluzzi JD et al. | β | 2005 | β |
| Adolescence, schizophrenia and drug abuse: a window of vulnerability. | van Nimwegen L et al. | β | 2005 | β |
| Control of the reinforcing effects of nicotine by associated environmental stimuli in animals and humans. | Le Foll B et al. | β | 2005 | β |
| Differential effects of psychoactive drugs in adolescents and adults. | Izenwasser S | β | 2005 | β |
| Differential expression of arc mRNA and other plasticity-related genes induced by nicotine in adolescent rat forebrain. | Schochet TL et al. | β | 2005 | β |
| Genetic influences on smoking: a brief review. | Al Koudsi N et al. | β | 2005 | β |
| How can drug addiction help us understand obesity? | Volkow ND et al. | β | 2005 | β |
| Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence. | Malaiyandi V et al. | β | 2005 | β |
| Maternal exposure of rats to nicotine via infusion during gestation produces neurobehavioral deficits and elevated expression of glial fibrillary acidic protein in the cerebellum and CA1 subfield in the offspring at puberty. | Abdel-Rahman A et al. | β | 2005 | β |
| Nicotine addiction and comorbidity with alcohol abuse and mental illness. | Dani JA et al. | β | 2005 | β |
| Periadolescent morphine exposure alters subsequent behavioral sensitivity to morphine in adult rats. | White DA et al. | β | 2005 | β |
| Periadolescent nicotine administration produces enduring changes in dendritic morphology of medium spiny neurons from nucleus accumbens. | McDonald CG et al. | β | 2005 | β |
| Periadolescent nicotine exposure causes heterologous sensitization to cocaine reinforcement. | McMillen BA et al. | β | 2005 | β |
| Periadolescent rats (P41-50) exhibit increased susceptibility to D-methamphetamine-induced long-term spatial and sequential learning deficits compared to juvenile (P21-30 or P31-40) or adult rats (P51-60). | Vorhees CV et al. | β | 2005 | β |
| Adolescent exposure to cannabinoids induces long-lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons. | Pistis M et al. | β | 2004 | β |
| Age-dependent effects of nicotine on locomotor activity and conditioned place preference in rats. | Belluzzi JD et al. | β | 2004 | β |
| Behavioral and neurochemical vulnerability during adolescence in mice: studies with nicotine. | Adriani W et al. | β | 2004 | β |
| Drug addiction: the neurobiology of behaviour gone awry. | Volkow ND et al. | β | 2004 | β |
| Neurochemical alterations produced by daily nicotine exposure in periadolescent vs. adult male rats. | Collins SL et al. | β | 2004 | β |
| Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal. | Abreu-VillaΓ§a Y et al. | β | 2004 | β |
| Risk taking and novelty seeking in adolescence: introduction to part I. | Kelley AE et al. | β | 2004 | β |
| Sex differences in voluntary oral nicotine consumption by adolescent mice: a dose-response experiment. | Klein LC et al. | β | 2004 | β |
| The reality of comorbidity: depression and drug abuse. | Volkow ND | β | 2004 | β |
| Windows of vulnerability to psychopathology and therapeutic strategy in the adolescent rodent model. | Adriani W et al. | β | 2004 | β |