No electrocortical evidence of automatic mismatch dysfunction in children of alcoholics.
- Authors
- van der Stelt, O; Gunning, W B; Snel, J; Kok, A
- Year
- 1997
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 9194906
- DOI
- 10.1097/00000374-199706000-00001
The mismatch negativity (MMN) event-related potential (ERP) component is an automatic, attention-independent brain response to auditory stimulus change, which has been reported to be smaller in alcoholics relative to nonalcoholic controls. To determine whether MMN decrements might be a trait marker of alcoholism that is also present in nonalcoholic individuals at high risk for developing alcoholism, we investigated MMN in 9- to 18-year-old children of alcoholics (n = 20) and control children (n = 20) in three different stimulus conditions using a passive auditory oddball paradigm. There were no statistically significant between-group differences observed in amplitude, scalp topography, and peak latency of MMN. These findings, if replicated, suggest that reported MMN decrements in alcoholics most likely represent a state marker, and not a trait marker, of alcoholism. Also, inasmuch as another ERP component, the P300, is attention-dependent and reported to be smaller in children of alcoholics, the present results implicate that deviations in attentive, but not in automatic, information processing are associated with alcoholism vulnerability.
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External
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| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | — | 2014 | → |
| Altered visual information processing systems in bipolar disorder: evidence from visual MMN and P3. | Maekawa T et al. | — | 2013 | → |
| Age-related dissociation of sensory and decision-based auditory motion processing. | Ludwig AA et al. | — | 2012 | → |
| Application of electroencephalography to the study of cognitive and brain functions in schizophrenia. | van der Stelt O et al. | — | 2007 | → |
| Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures. | Turetsky BI et al. | — | 2007 | → |
| Effects of chronic alcohol consumption in a visual attention task and an auditory oddball task: an event-related potential study. | Bijl S et al. | — | 2005 | → |
| Mismatch negativity: no difference between controls and abstinent alcoholics. | Fein G et al. | — | 2004 | → |
| Mismatch negativity in subjects at high risk for alcoholism. | Zhang XL et al. | — | 2001 | → |
| Mismatch negativity in young children of alcoholics from high-density families. | Rodríguez Holguín S et al. | — | 1998 | → |