Ethanol withdrawal in rats is attenuated by intracerebroventricular administration of neuropeptide Y.
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- Authors
- Woldbye, David P D; Ulrichsen, Jakob; Haugbøl, Steven; Bolwig, Tom G
- Year
- 2002
- Journal
- Alcohol and alcoholism (Oxford, Oxfordshire)
- PMID
- 12107031
- DOI
- 10.1093/alcalc/37.4.318
AIMS: The effects of intracerebroventricular administration of neuropeptide Y (NPY) on ethanol withdrawal were studied in rats. METHODS: Ethanol was administered intragastrically five times daily for 4 days. At 16-17 h after the last infusion of ethanol, rats were rated for withdrawal using a score based on three signs: irritability, tremor and rigidity. Subsequently, the rats received an injection of NPY (12 or 24 nmol) or vehicle and were rated for signs of withdrawal. RESULTS: At both doses, NPY significantly reduced ethanol withdrawal, the effect of the larger dose being more pronounced. CONCLUSIONS: Our results are consistent with the concept that NPY receptors are centrally involved in the regulation of neuronal excitability and might form a novel therapeutic target for treatment of ethanol withdrawal and other states of neuronal hyperexcitability.
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|---|---|---|
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | 2008 | 18828811 |
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External
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