Auditory and visual P300 event related potentials are not altered in medically and psychiatrically normal chronic marihuana users.
- Authors
- Patrick, G; Straumanis, J J; Struve, F A; Nixon, F; Fitz-Gerald, M J; Manno, J E; Soucair, M
- Year
- 1995
- Journal
- Life sciences
- PMID
- 7776842
- DOI
- 10.1016/0024-3205(95)00199-g
Attempts to use Event Related Potentials, particularly the cognitive or P300 evoked potential, as measures of CNS effects of THC use have been infrequent and have produced inconsistent results. We published a pilot study in which psychiatric patient THC users had significantly prolonged auditory P300 latencies and reduced amplitudes as contrasted with non-users. Because psychiatric diagnoses and medication effects could not be controlled, we repeated the study with medically and psychiatrically normal subjects selected with extremely stringent exclusion criteria and screening procedures. P300 latency differences between THC users and controls were not detected. Using all subjects, THC users displayed reduced auditory and visual P300 amplitudes. However, when age differences between THC users and controls were removed, all significant P300 amplitude differences were removed as well. The contaminating effect of using psychiatric patients in THC research is discussed and the importance of using carefully screened normal subjects in studies of neurophysiological abuse drug effects is stressed.
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In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| An Exploratory Study of Early Auditory Evoked Potentials in Cannabis Smokers. | Baiduc RR et al. | β | 2020 | β |
| The cannabinoid system and visual processing: a review on experimental findings and clinical presumptions. | Schwitzer T et al. | β | 2015 | β |
| Neural correlates of performance monitoring in chronic cannabis users and cannabis-naive controls. | Fridberg DJ et al. | β | 2013 | β |
| Dose-related modulation of event-related potentials to novel and target stimuli by intravenous ΞβΉ-THC in humans. | D'Souza DC et al. | β | 2012 | β |
| Event-Related Oscillations in Alcoholism Research: A Review. | Pandey AK et al. | β | 2012 | β |
| Cannabis with high Ξ΄9-THC contents affects perception and visual selective attention acutely: an event-related potential study. | BΓΆcker KB et al. | β | 2010 | β |
| Chronic cannabis users show altered neurophysiological functioning on Stroop task conflict resolution. | Battisti RA et al. | β | 2010 | β |
| Recent EEG and ERP findings in substance abusers. | Ceballos NA et al. | β | 2009 | β |
| Cannabis use disrupts eyeblink conditioning: evidence for cannabinoid modulation of cerebellar-dependent learning. | Skosnik PD et al. | β | 2008 | β |
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