Drug abuse as self-medication for depression: an empirical study.
paper
Cited
Public
Unavailable
- Authors
- Weiss, R D; Griffin, M L; Mirin, S M
- Year
- 1992
- Journal
- The American journal of drug and alcohol abuse
- PMID
- 1562010
- DOI
- 10.3109/00952999208992825
The authors empirically studied the self-medication hypothesis of drug abuse by examining drug effects and motivation for drug use in 494 hospitalized drug abusers. Most patients reported that they used drugs in response to depressive symptoms and experienced mood elevation, regardless of their drug of choice. Drug use to relieve depressive symptoms was far more likely in men if they had major depression, but was equally common in women with and without major depression. Information regarding a history of self-medication may thus be more helpful in diagnosing major depression in men than in women. Difficulties in diagnosing psychiatric disorders in substance abusers are discussed, as are the limitations of obtaining retrospective data on drug-using behavior. The implications of these limitations on the generalizability of the findings are reviewed.
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| Recreational substance use is linked with difficulty in recalling personal experiences. | Levent A et al. | — | 2025 | → |
| Self-medication of pain and discomfort with alcohol and other substances by people with HIV infection and substance use disorder: preliminary findings from a secondary analysis. | Stein MD et al. | — | 2024 | → |
| Subjective stress and any drinking during alcohol treatment: Disentangling within and between person autoregressive effects. | Witkiewitz K et al. | — | 2024 | → |
| Drinking Motives, Alcohol Misuse, and Internalizing and Externalizing Psychopathology across College: A Cross-Lagged Panel Study. | Savage JE et al. | — | 2023 | → |
| Predicting Alcohol-Related Memory Problems in Older Adults: A Machine Learning Study with Multi-Domain Features. | Kamarajan C et al. | — | 2023 | → |
| The experience of mood disorder and substance use: An integrative review. | Crowe M et al. | — | 2023 | → |
| Cholinergic and dopaminergic-mediated motivated behavior in healthy states and in substance use and mood disorders. | Nunes EJ et al. | — | 2022 | → |
| Gender differences in clinical characteristics of emergency department patients involving illicit drugs use with analytical confirmation. | Weng TI et al. | — | 2022 | → |
| Risk Management in First Aid for Acute Drug Intoxication. | Piccioni A et al. | — | 2020 | → |
| Sexual Performance Anxiety. | Pyke RE | — | 2020 | → |
| Brain interrupted: Early life traumatic brain injury and addiction vulnerability. | Cannella LA et al. | — | 2019 | → |
| Dimensions of the Parent-Child Relationship: Effects on Substance Use in Adolescence and Adulthood. | Mak HW et al. | — | 2019 | → |
| History of regular nonmedical sedative and/or alcohol use differentiates substance-use patterns and consequences among chronic heroin users. | Moses TEH et al. | — | 2019 | → |
| Professional and Volunteer Refugee Aid Workers-Depressive Symptoms and Their Predictors, Experienced Traumatic Events, PTSD, Burdens, Engagement Motivators and Support Needs. | Borho A et al. | — | 2019 | → |
| Predictors of Daily Pain Medication Use in Individuals with Recurrent Back Pain. | Sturgeon JA et al. | — | 2018 | → |
| Prevalence, Diagnosis, and Treatment Rates of Mood Disorders among Opioid Users under Criminal Justice Supervision. | Mbaba M et al. | — | 2018 | → |
| Alcohol and drug toxicology screens at time of hospitalization do not predict PTSD or depression after traumatic injury. | McLaughlin C et al. | — | 2017 | → |
| Alcohol, stress, and glucocorticoids: From risk to dependence and relapse in alcohol use disorders. | Blaine SK et al. | — | 2017 | → |
| Dynorphin/Kappa Opioid Receptor Signaling in Preclinical Models of Alcohol, Drug, and Food Addiction. | Karkhanis A et al. | — | 2017 | → |
| Forecasting state-level premature deaths from alcohol, drugs, and suicides using Google Trends data. | Parker J et al. | — | 2017 | → |
| No Reliable Evidence That Emotional Disorders Are Proximal Antecedents, Concomitants, or Short-Term Consequences of First Episode Alcohol Use Disorders in a Representative Community Sample. | Farmer RF et al. | — | 2017 | → |
| Psilocybin for treating substance use disorders? | de Veen BT et al. | — | 2017 | → |
| Maternal Separation Impairs Cocaine-Induced Behavioural Sensitization in Adolescent Mice. | Gracia-Rubio I et al. | — | 2016 | → |
| Unnatural pregnancy deaths in Las Vegas: A descriptive study. | Mahesan Paul AB et al. | — | 2016 | → |
| Adolescent obesity and future substance use: Incorporating the psychosocial context. | Lanza HI et al. | — | 2015 | → |
| Associations between childhood trauma and non-fatal overdose among people who inject drugs. | Lake S et al. | — | 2015 | → |
| A typology of drug selling among young adults in the United States. | Vaughn MG et al. | — | 2015 | → |
| Chronic physical health problems moderate changes in depression and substance use among dual diagnosed individuals during and after treatment. | Cui R et al. | — | 2015 | → |
| Further evidence of self-medication: personality factors influencing drug choice in substance use disorders. | McKernan LC et al. | — | 2015 | → |
| Alcohol Use is Not Directly Related to the Perceived Control of Depressive Symptoms in Patients with Depressive Symptoms. | Skule C et al. | — | 2014 | → |
| Examining moderation analyses in propensity score methods: application to depression and substance use. | Green KM et al. | — | 2014 | → |
| Self-loathing aspects of depression reduce postoperative opioid cessation rate. | Hah JM et al. | — | 2014 | → |
| Subtypes of attention deficit-hyperactivity disorder (ADHD) and cannabis use. | Loflin M et al. | — | 2014 | → |
| Gender differences in the presence of drugs in violent deaths. | Sheehan CM et al. | — | 2013 | → |
| The moderating effect of parental illicit substance use disorders on the relation between adolescent depression and subsequent illicit substance use disorders. | Gorka SM et al. | — | 2013 | → |
| The role of depression and social support in non-fatal drug overdose among a cohort of injection drug users in a Canadian setting. | Pabayo R et al. | — | 2013 | → |
| A single episode of maternal deprivation impairs the motivation for cocaine in adolescent mice. | Martini M et al. | — | 2012 | → |
| Childhood and adolescent risk factors for comorbid depression and substance use disorders in adulthood. | Green KM et al. | — | 2012 | → |
| Childhood trauma, impulsivity, and executive functioning in crack cocaine users. | Narvaez JC et al. | — | 2012 | → |
| Developing effective health interventions for women who inject drugs: key areas and recommendations for program development and policy. | Pinkham S et al. | — | 2012 | → |
| Interrelationship of substance use and psychological distress over the life course among a cohort of urban African Americans. | Green KM et al. | — | 2012 | → |
| Psychiatric comorbidity in cocaine users treated in therapeutic community: substance-induced versus independent disorders. | Vergara-Moragues E et al. | — | 2012 | → |
| The association between non-medical prescription drug use, depressive symptoms, and suicidality among college students. | Zullig KJ et al. | — | 2012 | → |
| Time to abandon the self-medication hypothesis in patients with psychiatric disorders. | Lembke A | — | 2012 | → |
| A longitudinal study of risk factors for incident drug use in adults: findings from a representative sample of the US population. | Harrington M et al. | — | 2011 | → |
| Factors predicting substance dependence and psychotropic medication use among offenders in community corrections. | Jackson DO et al. | — | 2011 | → |
| [Influence of the social network on consumption in drug addicts exhibiting psychiatric comorbidity]. | Acier D et al. | — | 2011 | → |
| Self-report reasons for alcohol use in bipolar disorders: why drink despite the potential risks? | McDonald JL et al. | — | 2011 | → |
| Adverse events and substance use among female adolescent offenders: effects of coping and family support. | Robertson AA et al. | — | 2010 | → |
| Ecstasy (MDMA) and high prevalence psychiatric symptomatology: somatic anxiety symptoms are associated with polydrug, not ecstasy, use. | Bedi G et al. | — | 2010 | → |
| Reasons for substance use among adolescents with bipolar disorder. | Lorberg B et al. | — | 2010 | → |
| Effect of acute alcohol use on the lethality of suicide attempts in patients with mood disorders. | Sher L et al. | — | 2009 | → |
| Possible role of norepinephrine in cocaine-induced conditioned taste aversions. | Serafine KM et al. | — | 2009 | → |
| Self-medication of mood disorders with alcohol and drugs in the National Epidemiologic Survey on Alcohol and Related Conditions. | Bolton JM et al. | — | 2009 | → |
| Comorbid substance and mental disorders among rural Americans: results from the National Comorbidity Survey. | Simmons LA et al. | — | 2007 | → |
| Psychosocial and behavioral correlates of depressed mood among female methamphetamine users. | Semple SJ et al. | — | 2007 | → |
| Reasons for substance use and vulnerability factors in patients with substance use disorder and anxiety or mood disorders. | Bizzarri JV et al. | — | 2007 | → |
| An examination of self-medication and rebound effects: Psychiatric symptomatology before and after alcohol or drug relapse. | Tomlinson KL et al. | — | 2006 | → |
| 'Big build': hidden depression in men. | Brownhill S et al. | — | 2005 | → |
| Helplessness in the tail suspension test is associated with an increase in ethanol intake and its rewarding effect in female mice. | Pelloux Y et al. | — | 2005 | → |
| Relapse in alcohol- and drug-disordered adolescents with comorbid psychopathology: changes in psychiatric symptoms. | McCarthy DM et al. | — | 2005 | → |
| Clinical implications and methodological challenges in the study of the neuropsychological correlates of cannabis, stimulant, and opioid abuse. | Verdejo-García A et al. | — | 2004 | → |
| Single episode of maternal deprivation and adult depressive profile in mice: interaction with cannabinoid exposure during adolescence. | Macrì S et al. | — | 2004 | → |
| Substance use and perceived symptom improvement among patients with bipolar disorder and substance dependence. | Weiss RD et al. | — | 2004 | → |
| Relationships between personality and preferred substance and motivations for use among adolescent substance abusers. | Adams JB et al. | — | 2003 | → |
| The relationship between depressive symptoms and nonfatal overdose among a sample of drug users in Baltimore, Maryland. | Tobin KE et al. | — | 2003 | → |
| Clinical importance of inter-episode symptoms in patients with bipolar affective disorder. | Morriss R | — | 2002 | → |
| Cocaine-primed craving and its relationship to depressive symptomatology in individuals with cocaine dependence. | Elman I et al. | — | 2002 | → |
| Depression and substance use in a middle aged and older Puerto Rican population. | Weingartner K et al. | — | 2002 | → |
| Early life sexual abuse as a risk factor for crack cocaine use in a sample of community-recruited women at high risk for illicit drug use. | Freeman RC et al. | — | 2002 | → |
| Mental health, drug use, and the transition from welfare to work. | Montoya ID et al. | — | 2002 | → |
| Anger and depressive states among treatment-seeking drug abusers: testing the psychopharmacological specificity hypothesis. | Aharonovich E et al. | — | 2001 | → |
| General relations among drug use, alcohol use, and major indexes of psychopathology. | Mehrabian A | — | 2001 | → |
| Specifying the relations between affect and heavy alcohol use among young adults. | Hussong AM et al. | — | 2001 | → |
| Addictive behaviors and depression among African Americans residing in a public housing community. | Williams CD et al. | — | 2000 | → |
| Current concepts in the treatment of depression in alcohol-dependent patients. | McGrath PJ et al. | — | 2000 | → |
| Effects of Hypericum perforatum extract on ethanol intake, and on behavioral despair: a search for the neurochemical systems involved. | Panocka I et al. | — | 2000 | → |
| Flunitrazepam: more than a date rape drug. | Rickert VI et al. | — | 2000 | → |
| Individual differences among cocaine users. | Gunnarsdóttir ED et al. | — | 2000 | → |
| The relationship between eating disorders and substance use: moving beyond co-prevalence research. | Wolfe WL et al. | — | 2000 | → |
| The triad of substance abuse, violence, and depression are interrelated in pregnancy. | Horrigan TJ et al. | — | 2000 | → |
| Implications of depression on outcome from alcohol dependence: a 3-year prospective follow-up. | Hodgins DC et al. | — | 1999 | → |
| [Mental disorders as risk factors for the development of cocaine abuse/dependence: case-control study]. | Lopes CS et al. | — | 1999 | → |
| Order of onset of substance abuse and depression in a sample of depressed outpatients. | Abraham HD et al. | — | 1999 | → |
| Symptomatology of depression and anxiety in female "social drinkers". | Bjork JM et al. | — | 1999 | → |
| Anxiety and alcohol abuse in patients in treatment for depression. | Fischer EH et al. | — | 1998 | → |
| Comorbidity of conduct and depressive problems at sixth grade: substance use outcomes across adolescence. | Miller-Johnson S et al. | — | 1998 | → |
| Self-medication with alcohol appears not to be an effective treatment for the control of depression. | Hendrie CA et al. | — | 1998 | → |
| Social network characteristics as mediators in the relationship between sexual abuse and HIV risk. | Miller M et al. | — | 1998 | → |
| Substance use and abuse among patients with comorbid dysthymia and substance disorder. | Eames SL et al. | — | 1998 | → |
| The effects of cocaine and the amphetamines on brain and behavior: a conference report. | Battaglia G et al. | — | 1998 | → |
| Clinical epidemiology of comorbid dysthymia and substance disorder. | Westermeyer J et al. | — | 1997 | → |
| Course and severity of substance abuse among patients with comorbid major depression. | Westermeyer J et al. | — | 1997 | → |
| Gender differences in DSM-IV alcohol use disorders and major depression as distributed in the general population: clinical implications. | Hanna EZ et al. | — | 1997 | → |
| Services for perinatal women with substance abuse and mental health disorders: the unmet need. | Grella CE | — | 1997 | → |
| Substance abuse and homelessness: social selection or social adaptation? | Johnson TP et al. | — | 1997 | → |
| The familial aggregation of depressive symptoms, antisocial behavior, and alcohol abuse. | Stallings MC et al. | — | 1997 | → |
| Diagnosing comorbidity in substance abusers: a comparison of the test-retest reliability of two interviews. | Ross HE et al. | — | 1995 | → |
| Identifying substance abuse in maltreating families: a child welfare challenge. | Dore MM et al. | — | 1995 | → |
| Preferences for ethanol and diazepam in anxious individuals: an evaluation of the self-medication hypothesis. | Chutuape MA et al. | — | 1995 | → |
| Specificity of substance use in anxiety-disordered subjects. | Goldenberg IM et al. | — | 1995 | → |
| Alcohol and Other Drug Abuse Among Women. | Lex BW | — | 1994 | → |
| Correlates of cocaine/crack use among inner-city incarcerated adolescents. | Kang SY et al. | — | 1994 | → |
| Diagnosis, health beliefs, and risk of HIV infection in psychiatric patients. | McDermott BE et al. | — | 1994 | → |
| Empirical assessment of the self-medication hypothesis among dually diagnosed inpatients. | Castaneda R et al. | — | 1994 | → |
| Current epidemiology of comorbidity of psychiatric and addictive disorders. | Miller NS et al. | — | 1993 | → |