Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice.
paper
Cited
Public
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- Authors
- Xu, M; Hu, X T; Cooper, D C; Moratalla, R; Graybiel, A M; White, F J; Tonegawa, S
- Year
- 1994
- Journal
- Cell
- PMID
- 8001143
- DOI
- 10.1016/0092-8674(94)90026-4
The brain mesoaccumbens dopamine system is intricately involved in the psychomotor stimulant activities of cocaine. However, the extent to which different dopamine receptors mediate these effects has not yet been firmly established. The present study used dopamine D1 receptor mutant mice produced by gene targeting to investigate the role of this receptor in the effects induced by cocaine. In contrast with wild-type mice, which showed a dose-dependent increase in locomotion, D1 mutant mice exhibited a dose-dependent decrease. Electrophysiological studies of dopamine-sensitive nucleus accumbens neurons demonstrated a marked reduction in the inhibitory effects of cocaine on the generation of action potentials. In addition, the inhibitory effects of dopamine as well as D1 and D2 agonists were almost completely abolished, whereas those of serotonin were unaffected. D2-like dopamine receptor binding was also normal. These results demonstrate the essential role of the D1 receptor in the locomotor stimulant effects of cocaine and in dopamine-mediated neurophysiological effects within the nucleus accumbens.
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| Title | Year | PMID |
|---|---|---|
| The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach. | 2012 | 22358648 |
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| Transgenic mice bearing a human mutant thyroid hormone beta 1 receptor manifest thyroid function anomalies, weight reduction, and hyperactivity. | Wong R et al. | β | 1997 | β |
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| The biological, social and clinical bases of drug addiction: commentary and debate. | Altman J et al. | β | 1996 | β |
| Which dopamine receptor(s) do we need for motor function? Lessons from gene targeting and translational blockade. | Stoessl AJ | β | 1996 | β |
| Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. | Hein L et al. | β | 1995 | β |
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| Prenatal stress in rats facilitates amphetamine-induced sensitization and induces long-lasting changes in dopamine receptors in the nucleus accumbens. | Henry C et al. | β | 1995 | β |
| The dopamine D1 receptor antagonist SCH 23390 can exert D1 agonist-like effects on rat nucleus accumbens neurons. | Wachtel SR et al. | β | 1995 | β |