Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence.
- Authors
- Dahl, John P; Cubells, Joseph F; Ray, Riju; Weller, Andrew E; Lohoff, Falk W; Ferraro, Thomas N; Oslin, David W; Kampman, Kyle M; Dackis, Charles; Tang, Yilang; Gelernter, Joel; Kranzler, Henry R; O'Brien, Charles P; Berrettini, Wade H
- Year
- 2006
- Journal
- Addiction biology
- PMID
- 16759340
- DOI
- 10.1111/j.1369-1600.2006.00005.x
While the exact physiological mechanisms underlying cocaine dependence remain unclear, a growing body of evidence indicates a role for the serotonergic neurotransmitter system in the pathology of this substance use disorder. The focus of the present study is to determine whether genetic variation in the tryptophan hydroxylase-2 (TPH2) gene, which encodes the enzyme responsible for synthesis of the majority of the serotonin contained in neurons of the central nervous system, contributes to the pathophysiology of cocaine dependence. To examine this hypothesis, we used a case-control study design in which the genotype and allele distributions for six single nucleotide polymorphisms (SNPs) in the TPH2 gene were compared between cocaine-dependent (n = 299) and control individuals (n = 208) of African descent. The results indicate that none of the SNPs in the TPH2 gene examined in this study associate with the cocaine-dependent phenotype. This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects.
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In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Environmental, genetic and epigenetic contributions to cocaine addiction. | Pierce RC et al. | — | 2018 | → |
| TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis. | Ottenhof KW et al. | — | 2018 | → |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | — | 2017 | → |
| Serotonin Transporter and Tryptophan Hydroxylase Gene Variations Mediate Working Memory Deficits of Cocaine Users. | Havranek MM et al. | — | 2015 | → |
| The role of serotonin in drug use and addiction. | Müller CP et al. | — | 2015 | → |
| Association study of 37 genes related to serotonin and dopamine neurotransmission and neurotrophic factors in cocaine dependence. | Fernàndez-Castillo N et al. | — | 2013 | → |
| Implications of genome wide association studies for addiction: are our a priori assumptions all wrong? | Hall FS et al. | — | 2013 | → |
| Current perspectives on the neurobiology of drug addiction: a focus on genetics and factors regulating gene expression. | Duncan JR | — | 2012 | → |
| The genetics of addiction-a translational perspective. | Agrawal A et al. | — | 2012 | → |
| Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis. | Kobayashi H et al. | — | 2011 | → |
| Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment. | Tzvetkov MV et al. | — | 2008 | → |
| No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependence. | Weller AE et al. | — | 2006 | → |