Transforming Growth Factor type beta and Smad family signaling in stem cell function.
- Authors
- Seuntjens, Eve; Umans, Lieve; Zwijsen, An; Sampaolesi, Maurilio; Verfaillie, Catherine M; Huylebroeck, Danny
- Year
- 2009
- Journal
- Cytokine & growth factor reviews
- PMID
- 19892581
- DOI
- 10.1016/j.cytogfr.2009.10.005
Ligands of the Transforming Growth Factor type beta (TGFbeta) family exert multiple and sometimes opposite effects on most cell types in vivo depending on cellular context, which mainly includes the stage of the target cell, the local environment of this cell or niche, and the identity and the dosage of the ligand. Significant progress has been made in the molecular dissection of the regulation of the activity of the ligands and their intracellular signal transduction pathways, including via the canonical Smad pathway where Smads interact with many transcription factors. This knowledge together with results from functional studies within the embryology and stem cell research fields is giving us insight in the role of individual ligands and other components of this signaling system and where and how it regulates many properties of embryonic and adult stem/progenitor cells, which is anticipated to contribute to successful cell-based therapy in the future. We review and discuss recent progress on the effects of Nodal/Activin and Bone Morphogenetic Proteins (BMPs) and their canonical signaling in cells with stem cell properties. We focus on embryonic stem cells and their maintenance and pluripotency, and conversion into selected cell types of neuroectoderm, mesoderm and endoderm, on induced pluripotent cells and on neurogenic cells in the adult brain.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| A genome wide association study of fast beta EEG in families of European ancestry. | 2017 | 28040410 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Signaling network exploration of microRNA140-5p in response to TMJ-OA pathological changes. | Li W et al. | β | 2026 | β |
| TGFΞ² family signaling in human stem cell self-renewal and differentiation. | Liu S et al. | β | 2024 | β |
| Mesenchymal stem cells: An efficient cellΒ therapy for tendon repair (Review). | Jiang L et al. | β | 2023 | β |
| Neural Progenitor Cells and the Hypothalamus. | Makrygianni EA et al. | β | 2023 | β |
| Adipose-derived mesenchymal stromal cell-derived exosomes promote tendon healing by activating both SMAD1/5/9 and SMAD2/3. | Liu H et al. | β | 2021 | β |
| Binding of Gtf2i-Ξ²/Ξ΄ transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and inΒ vitro. | Pan Y et al. | β | 2021 | β |
| Functional roles of human Up-frameshift suppressor 3 (UPF3) proteins: From nonsense-mediated mRNA decay to neurodevelopmental disorders. | Deka B et al. | β | 2021 | β |
| Guide Cells Support Muscle Regeneration and Affect Neuro-Muscular Junction Organization. | Ronzoni FL et al. | β | 2021 | β |
| Integrative and perturbation-based analysis of the transcriptional dynamics of TGFΞ²/BMP system components in transition from embryonic stem cells to neural progenitors. | Dries R et al. | β | 2020 | β |
| Activin/Smad2-induced Histone H3 Lys-27 Trimethylation (H3K27me3) Reduction Is Crucial to Initiate Mesendoderm Differentiation of Human Embryonic Stem Cells. | Wang L et al. | β | 2017 | β |
| A genome wide association study of fast beta EEG in families of European ancestry. | Meyers JL et al. | β | 2017 | β |
| miRβ146bβ5p promotes the neural conversion of pluripotent stem cells by targeting Smad4. | Zhang N et al. | β | 2017 | β |
| TGF-Ξ² participates choroid neovascularization through Smad2/3-VEGF/TNF-Ξ± signaling in mice with Laser-induced wet age-related macular degeneration. | Wang X et al. | β | 2017 | β |
| WNT/Ξ²-Catenin signaling pathway regulates non-tumorigenesis of human embryonic stem cells co-cultured with human umbilical cord mesenchymal stem cells. | Chang YH et al. | β | 2017 | β |
| Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact. | Karousis ED et al. | β | 2016 | β |
| A satellite cell-specific knockout of the androgen receptor reveals myostatin as a direct androgen target in skeletal muscle. | Dubois V et al. | β | 2014 | β |
| Lefty1 and lefty2 control the balance between self-renewal and pluripotent differentiation of mouse embryonic stem cells. | Kim DK et al. | β | 2014 | β |
| Osteosarcoma cells promote the production of pro-tumor cytokines in mesenchymal stem cells by inhibiting their osteogenic differentiation through the TGF-Ξ²/Smad2/3 pathway. | Tu B et al. | β | 2014 | β |
| Posttranscriptional control of the stem cell and neurogenic programs by the nonsense-mediated RNA decay pathway. | Lou CH et al. | β | 2014 | β |
| Aptamers and their potential to selectively target aspects of EGF, Wnt/Ξ²-catenin and TGFΞ²-smad family signaling. | Conidi A et al. | β | 2013 | β |
| Four amino acids within a tandem QxVx repeat in a predicted extended Ξ±-helix of the Smad-binding domain of Sip1 are necessary for binding to activated Smad proteins. | Conidi A et al. | β | 2013 | β |
| Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis. | Anacker C et al. | β | 2013 | β |
| miR-125b regulates the early steps of ESC differentiation through dies1 in a TGF-independent manner. | Battista M et al. | β | 2013 | β |
| Myostatin inhibits proliferation of human urethral rhabdosphincter satellite cells. | Akita Y et al. | β | 2013 | β |
| Safety and efficient ex vivo expansion of stem cells using platelet-rich plasma technology. | Anitua E et al. | β | 2013 | β |
| Adult neurogenesis and brain regeneration in zebrafish. | Kizil C et al. | β | 2012 | β |
| Androgens and skeletal muscle: cellular and molecular action mechanisms underlying the anabolic actions. | Dubois V et al. | β | 2012 | β |
| A regulatory loop involving Dies1 and miR-125a controls BMP4 signaling in mouse embryonic stem cells. | Parisi S et al. | β | 2012 | β |
| BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells. | Li Z et al. | β | 2012 | β |
| Control of stem cell fate and function by engineering physical microenvironments. | Kshitiz et al. | β | 2012 | β |
| High glucose facilitates cell cycle arrest of rat bone marrow multipotent adult progenitor cells through transforming growth factor-Ξ²1 and extracellular signal-regulated kinase 1/2 signalling without changing Oct4 expression. | Luo M et al. | β | 2012 | β |
| The protection of MSCs from apoptosis in nerve regeneration by TGFΞ²1 through reducing inflammation and promoting VEGF-dependent angiogenesis. | Luo H et al. | β | 2012 | β |
| Loss of function of e-cadherin in embryonic stem cells and the relevance to models of tumorigenesis. | Mohamet L et al. | β | 2011 | β |
| Proteomics and pluripotency. | Brumbaugh J et al. | β | 2011 | β |
| Reproductive aging: insights from model organisms. | Ye AL et al. | β | 2011 | β |
| The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability. | Jeub M et al. | β | 2011 | β |
| Feasibility of using gene expression analysis to study canine soft tissue sarcomas. | Mahoney JA et al. | β | 2010 | β |
| Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells. | Fei T et al. | β | 2010 | β |
| Cellular mechanisms and local progenitor activation to regulate skeletal muscle mass. | Cassano M et al. | β | 2009 | β |