Prospective study of alcohol consumption and risk of coronary disease in men.
paper
Cited
Public
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- Authors
- Rimm, E B; Giovannucci, E L; Willett, W C; Colditz, G A; Ascherio, A; Rosner, B; Stampfer, M J
- Year
- 1991
- Journal
- Lancet (London, England)
- PMID
- 1678444
- DOI
- 10.1016/0140-6736(91)90542-w
Although an inverse association between alcohol consumption and risk of coronary artery disease has been consistently found in several types of studies, some have argued that the association is due at least partly to the inclusion in the non-drinking reference group of men who abstain because of pre-existing disease. The association between self-reported alcohol intake and coronary disease was studied prospectively among 51,529 male health professionals. In 1986 the participants completed questionnaires about food and alcohol intake and medical history, heart disease risk factors, and dietary changes in the previous 10 years. Follow-up questionnaires in 1988 sought information about newly diagnosed coronary disease. 350 confirmed cases of coronary disease occurred. After adjustment for coronary risk factors, including dietary intake of cholesterol, fat, and dietary fibre, increasing alcohol intake was inversely related to coronary disease incidence (p for trend less than 0.001). Exclusion of 10,302 current non-drinkers or 16,342 men with disorders potentially related to coronary disease (eg, hypertension, diabetes, and gout) which might have led men to reduce their alcohol intake, did not substantially affect the relative risks. These findings support the hypothesis that the inverse relation between alcohol consumption and risk of coronary disease is causal.
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| Red grape juice polyphenols alter cholesterol homeostasis and increase LDL-receptor activity in human cells in vitro. | DΓ‘valos A et al. | β | 2006 | β |
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| Inhibition of thrombin-induced signaling by resveratrol and quercetin: effects on adenosine nucleotide metabolism in endothelial cells and platelet-neutrophil interactions. | Kaneider NC et al. | β | 2004 | β |
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| Plasma and dietary carotenoids, and the risk of prostate cancer: a nested case-control study. | Wu K et al. | β | 2004 | β |
| Polyphenolic compounds from Cognac induce vasorelaxation in vitro and decrease post-ischaemic cardiac infarction after an oral administration. | Ralay Ranaivo H et al. | β | 2004 | β |
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| The antiinflammatory effects of purple grape juice consumption in subjects with stable coronary artery disease. | Albers AR et al. | β | 2004 | β |
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| Vitamin intake is not associated with community-acquired pneumonia in U.S. men. | Merchant AT et al. | β | 2004 | β |
| Abstention, alcohol use and risk of myocardial infarction in men and women taking account of social support and working conditions: the SHEEP case-control study. | RomelsjΓΆ A et al. | β | 2003 | β |
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