Array CGH analysis of chronic lymphocytic leukemia reveals frequent cryptic monoallelic and biallelic deletions of chromosome 22q11 that include the PRAME gene.
paper
Cited
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- Authors
- Gunn, Shelly R; Bolla, Aswani R; Barron, Lynn L; Gorre, Mercedes E; Mohammed, Mansoor S; Bahler, David W; Mellink, Clemens H M; van Oers, Marinus H J; Keating, Michael J; Ferrajoli, Alessandra; Coombes, Kevin R; Abruzzo, Lynne V; Robetorye, Ryan S
- Year
- 2009
- Journal
- Leukemia research
- PMID
- 19027161
- DOI
- 10.1016/j.leukres.2008.10.010
We used BAC array-based CGH to detect genomic imbalances in 187 CLL cases. Submicroscopic deletions of chromosome 22q11 were observed in 28 cases (15%), and the frequency of these deletions was second only to loss of the 13q14 region, the most common genomic aberration in CLL. Oligonucleotide-based array CGH analysis showed that the 22q11 deletions ranged in size from 0.34 Mb up to approximately 1 Mb. The minimally deleted region included the ZNF280A, ZNF280B, GGTLC2, and PRAME genes. Quantitative real-time PCR revealed that ZNF280A, ZNF280B, and PRAME mRNA expression was significantly lower in the 22q11 deletion cases compared to non-deleted cases.
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