Blunted hypothalamic-pituitary-adrenocortical axis responsivity to stress in persons with a family history of alcoholism.
paper
Cited
Public
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- Authors
- Sorocco, Kristen H; Lovallo, William R; Vincent, Andrea S; Collins, Frank L
- Year
- 2006
- Journal
- International journal of psychophysiology : official journal of the International Organization of Psychophysiology
- PMID
- 16360227
- DOI
- 10.1016/j.ijpsycho.2005.10.009
- PMCID
- PMC2267108
Abstinent alcoholics show a blunted stress cortisol response that may be a consequence of drinking or a preexisting risk marker. We tested cortisol responses to psychological stress in 186 18-30 year-old, healthy social drinkers having no personal history of alcohol or drug dependence, 91 of whom had one or two alcoholic parents (FH+) and 95 having no family alcoholism for two generations (FH-). We predicted that, similar to alcoholic patients, the FH+ would have reduced stress cortisol responses that would be partially determined by their temperament characteristics, specifically antisocial tendencies as measured by the California Psychological Inventory. On a stress day, subjects performed continuous simulated public speaking and mental arithmetic tasks for 45 min, and on a control day they sat and rested for the same time period. The FH+ who were low in sociability had smaller cortisol responses than FH-, high-sociability persons (t=2.27, p=.02). These two groups were not different in diurnal cortisol secretion patterns or affective responses to the stressors. Persons with a familial risk for alcoholism who have more antisocial tendencies may have altered central nervous system responses to emotionally relevant social challenges. Disrupted cortisol stress responses may serve as a risk marker for the development of substance use disorders.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Stress-response pathways are altered in the hippocampus of chronic alcoholics. | 2013 | 23981442 |
| Neural circuitry associated with risk for alcohol use disorders. | 2010 | 19685291 |
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