Association of Resting Heart Rate and Blood Pressure in Late Adolescence With Subsequent Mental Disorders: A Longitudinal Population Study of More Than 1 Million Men in Sweden.
- Authors
- Latvala, Antti; Kuja-Halkola, Ralf; Rück, Christian; D'Onofrio, Brian M; Jernberg, Tomas; Almqvist, Catarina; Mataix-Cols, David; Larsson, Henrik; Lichtenstein, Paul
- Year
- 2016
- Journal
- JAMA psychiatry
- PMID
- 27784035
- DOI
- 10.1001/jamapsychiatry.2016.2717
IMPORTANCE: Differences in cardiovascular autonomic activity between individuals with psychiatric disorders and healthy controls have been observed, but whether cardiovascular autonomic abnormalities are associated with subsequent psychiatric disorders is unknown. OBJECTIVE: To investigate whether differences in cardiac autonomic function as indexed by resting heart rate and blood pressure are associated with psychiatric disorders during the lifetime of men in Sweden. DESIGN, SETTING, AND PARTICIPANTS: We conducted a longitudinal register-based study of Swedish men whose resting heart rate (n = 1 039 443) and blood pressure (n = 1 555 979) were measured at military conscription at a mean (SD) age of 18.3 (0.6) years during the period from 1969 to 2010, with register-based follow-up data available until the end of 2013. Analyses were performed from November 18, 2015, to June 9, 2016. MAIN OUTCOMES AND MEASURES: Dates of inpatient/outpatient diagnoses of anxiety disorders, obsessive-compulsive disorder, posttraumatic stress disorder, depressive disorders, bipolar disorder, schizophrenia, and substance use disorders and convictions for violent crimes, between 1973 and 2013, were obtained from nationwide registers. Adjustments were made for height, weight, body mass index, cardiorespiratory fitness, cognitive ability, and socioeconomic covariates. RESULTS: After adjustment for covariates, Cox regression models with up to 45 years of follow-up data showed that men (mean [SD] age of 18.3 [0.6] years at conscription) with resting heart rates above 82 beats per minute had a 69% (95% CI, 46%-94%) increased risk for obsessive-compulsive disorder, a 21% (95% CI, 11%-33%) increased risk for schizophrenia, and an 18% (95% CI, 13%-22%) increased risk for anxiety disorders compared with men with resting heart rates below 62 beats per minute. Similar associations were observed with systolic/diastolic blood pressure. In contrast, lower resting heart rate and lower systolic blood pressure were associated with substance use disorders and violent criminality. CONCLUSIONS AND RELEVANCE: Our results suggest that for men, differences in heart rate and blood pressure in late adolescence are associated with lifetime major psychiatric disorders, with higher levels associated with obsessive-compulsive disorder, schizophrenia, and anxiety disorders and lower levels associated with substance use disorders and violent behavior. Differences in autonomic nervous system functioning may predate or represent an early marker of psychiatric disorders.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genetic association study of childhood aggression across raters, instruments, and age. | 2021 | 34330890 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Disrupted physiological coregulation in youth at clinical high risk for psychosis: Insights from a dyadic interaction study. | Schreiber AM et al. | — | 2026 | → |
| Associations of schizophrenia with arrhythmic disorders and electrocardiogram traits: genetic exploration of population samples. | Treur JL et al. | — | 2025 | → |
| Characterization of cardiac autonomic dysfunction in acute Schizophrenia: a cluster analysis of heart rate variability parameters. | Refisch A et al. | — | 2025 | → |
| Heart rate and EEG gamma band connectivity in the ventral attention network during emotional movie stimulation in women with high emotion dysregulation. | Fusina F et al. | — | 2025 | → |
| Inter- and Intrapersonal Associations Between Physiology and Mental Health: A Longitudinal Study Using Wearables and Mental Health Surveys. | Presby D et al. | — | 2025 | → |
| Interoceptive Mechanisms and Emotional Processing. | Greenwood BM et al. | — | 2025 | → |
| Sleep efficiency is negatively associated with resting daytime heart rate in trauma-exposed premenopausal women. | Tahsin CT et al. | — | 2025 | → |
| Altered cardiac autonomic functioning associates with self-disorders in schizophrenia. | Sandsten KE et al. | — | 2024 | → |
| A Swedish population-based study to evaluate the usefulness of resting heart rate in the prediction of suicidal behavior among males. | Lannoy S et al. | — | 2024 | → |
| Clinical Characteristics of Asymptomatic Thromboembolism in Psychiatric Inpatients: A Retrospective Study. | Geng Y et al. | — | 2024 | → |
| Evaluating Machine Learning Stability in Predicting Depression and Anxiety Amidst Subjective Response Errors. | Ku WL et al. | — | 2024 | → |
| Lower autonomic arousal as a risk factor for criminal offending and unintentional injuries among female conscripts. | Oskarsson S et al. | — | 2024 | → |
| Physical Health and Transition to Psychosis in People at Clinical High Risk. | De Micheli A et al. | — | 2024 | → |
| Resting Heart Rate and Associations With Clinical Measures From the Project Baseline Health Study: Observational Study. | Feng KY et al. | — | 2024 | → |
| An RDoC-based approach to adolescent self-injurious thoughts and behaviors: The interactive role of social affiliation and cardiac arousal. | Nelson BW et al. | — | 2023 | → |
| Smartphone Photoplethysmography Pulse Rate Covaries With Stress and Anxiety During a Digital Acute Social Stressor. | Nelson BW et al. | — | 2023 | → |
| The Immigrant Experience and Alcohol Use: Heart Rate as a Source of Risk and Resilience. | Guerra C et al. | — | 2023 | → |
| Anxiety disorders and age-related changes in physiology. | Mutz J et al. | — | 2022 | → |
| Cardiovascular risk factors in attention-deficit/hyperactivity disorder: A family design study of Swedish conscripts. | Garcia-Argibay M et al. | — | 2022 | → |
| Children With PANS May Manifest POTS. | Chan A et al. | — | 2022 | → |
| Concurrent and prospective associations between fitbit wearable-derived RDoC arousal and regulatory constructs and adolescent internalizing symptoms. | Nelson BW et al. | — | 2022 | → |
| Exploring the Relationship Between Schizophrenia and Cardiovascular Disease: A Genetic Correlation and Multivariable Mendelian Randomization Study. | Veeneman RR et al. | — | 2022 | → |
| Heart rate and skin conductance associations with physical aggression, psychopathy, antisocial personality disorder and conduct disorder: An updated meta-analysis. | de Looff PC et al. | — | 2022 | → |
| Orexin/hypocretin system dysfunction in patients with Takotsubo syndrome: A novel pathophysiological explanation. | Knez R et al. | — | 2022 | → |
| Predicting Chronic Stress among Healthy Females Using Daily-Life Physiological and Lifestyle Features from Wearable Sensors. | Magal N et al. | — | 2022 | → |
| Resting Heart Rate and Cognitive Decline: A Meta-Analysis of Prospective Cohort Studies. | Kim HB et al. | — | 2022 | → |
| The Swedish military conscription register: opportunities for its use in medical research. | Ludvigsson JF et al. | — | 2022 | → |
| Variant connective tissue (joint hypermobility) and its relevance to depression and anxiety in adolescents: a cohort-based case-control study. | Eccles JA et al. | — | 2022 | → |
| Anxiety disorders and age-related changes in physiology | Mutz J et al. | — | 2021 | — |
| Cognitive ability and metabolic physical health in first-episode psychosis. | Whitson S et al. | — | 2021 | → |
| Genetic association study of childhood aggression across raters, instruments, and age. | Ip HF et al. | — | 2021 | → |
| Low autonomic arousal as a risk factor for reoffending: A population-based study. | Oskarsson S et al. | — | 2021 | → |
| Psychometrics, interpretation and clinical implications of hierarchical models of psychopathology. | Pettersson E et al. | — | 2021 | → |
| The causal nature of the association between resting pulse in late adolescence and risk for internalizing and externalizing disorders: a co-relative analysis in a national male Swedish sample. | Kendler KS et al. | — | 2021 | → |
| Brain and Physiological Markers of Autonomic Function Are Associated With Treatment-Related Improvements in Self-Reported Autonomic Dysfunction in Veterans With Gulf War Illness: An Exploratory Pilot Study. | Mathersul DC et al. | — | 2020 | → |
| Guidelines for wrist-worn consumer wearable assessment of heart rate in biobehavioral research. | Nelson BW et al. | — | 2020 | → |
| Neurobiological basis of chiropractic manipulative treatment of the spine in the care of major depression. | Kiani AK et al. | — | 2020 | → |
| Neurovisceral regulatory circuits of affective resilience in youth: Principal outline of a dynamic model of neurovisceral integration in development. | Koenig J | — | 2020 | → |
| The relationship between resting heart rate and aggression in males is racially variant. | Portnoy J et al. | — | 2020 | → |
| Conduct disorder. | Fairchild G et al. | — | 2019 | → |
| Predictive validity of objective measures of physical fitness for the new onset of mental disorders in adolescents and young adults. | Tacchi MJ et al. | — | 2019 | → |
| Sympathetic arousal in children with oppositional defiant disorder and its relation to emotional dysregulation. | Tonacci A et al. | — | 2019 | → |
| Underlying Psychophysiology of Dysregulation: Resting Heart Rate and Heart Rate Reactivity in Relation to Childhood Dysregulation. | Deutz MHF et al. | — | 2019 | → |
| Brain structural thickness and resting state autonomic function in adolescents with major depression. | Koenig J et al. | — | 2018 | → |
| Report of Autonomic Symptoms in a Clinical Sample of Veterans with Gulf War Illness. | Fox A et al. | — | 2018 | → |
| Sensitivity to psychosocial chronic stressors and adolescents' externalizing problems: Combined moderator effects of resting heart rate and parental psychiatric history. | Zandstra ARE et al. | — | 2018 | → |