CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism.
paper
Cited
Public
Unavailable
- Authors
- Peterson, Jonathan M; Seldin, Marcus M; Wei, Zhikui; Aja, Susan; Wong, G William
- Year
- 2013
- Journal
- American journal of physiology. Gastrointestinal and liver physiology
- PMID
- 23744740
- DOI
- 10.1152/ajpgi.00102.2013
- PMCID
- PMC3742855
CTRP3 is a secreted plasma protein of the C1q family that helps regulate hepatic gluconeogenesis and is downregulated in a diet-induced obese state. However, the role of CTRP3 in regulating lipid metabolism has not been established. Here, we used a transgenic mouse model to address the potential function of CTRP3 in ameliorating high-fat diet-induced metabolic stress. Both transgenic and wild-type mice fed a high-fat diet showed similar body weight gain, food intake, and energy expenditure. Despite similar adiposity to wild-type mice upon diet-induced obesity (DIO), CTRP3 transgenic mice were strikingly resistant to the development of hepatic steatosis, had reduced serum TNF-Ξ± levels, and demonstrated a modest improvement in systemic insulin sensitivity. Additionally, reduced hepatic triglyceride levels were due to decreased expression of enzymes (GPAT, AGPAT, and DGAT) involved in triglyceride synthesis. Importantly, short-term daily administration of recombinant CTRP3 to DIO mice for 5 days was sufficient to improve the fatty liver phenotype, evident as reduced hepatic triglyceride content and expression of triglyceride synthesis genes. Consistent with a direct effect on liver cells, recombinant CTRP3 treatment reduced fatty acid synthesis and neutral lipid accumulation in cultured rat H4IIE hepatocytes. Together, these results establish a novel role for CTRP3 hormone in regulating hepatic lipid metabolism and highlight its protective function and therapeutic potential in attenuating hepatic steatosis.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model. | 2019 | 29568101 |
| C1q/TNF-Related Protein 3 (CTRP3) Function and Regulation. | 2017 | 28640446 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Panx3 deficiency in mice impairs bone fracture healing and causes transient hypoglycemia in neonatal animals. | Jiang S et al. | β | 2026 | β |
| Association between circulating plasma CTRP3 levels and acute ischemic stroke: a systematic review and meta-analysis. | Niu Q et al. | β | 2025 | β |
| How Exercise Affects Exerkines in Metabolic Syndrome. | Babaei P et al. | β | 2025 | β |
| Impact of using supplemented thylakoids derived from spinach for 12β―weeks of high-intensity functional training on adipo-myokines in obese males. | Abbassi-Daloii A et al. | β | 2025 | β |
| Loss of CTRP10 results in female obesity with preserved metabolic health. | Chen F et al. | β | 2025 | β |
| Multifunctional Roles and Therapeutic Prospects of C1q/TNF-Related Protein 3 (CTRP3) in Human Diseases. | Wang QP et al. | β | 2025 | β |
| Orai channel pharmacological manipulation reduces metabolic flexibility in cardiac fibroblasts. | Pantoja Newman PDS et al. | β | 2025 | β |
| Unveiling the roles of CTRP family in cardiac remodeling. | Zhao S et al. | β | 2025 | β |
| An interpretable machine learning-based cerebrospinal fluid proteomics clock for predicting age reveals novel insights into brain aging. | Melendez J et al. | β | 2024 | β |
| gCTRP3 inhibits oophorectomyβinduced osteoporosis by activating the AMPK/SIRT1/Nrf2 signaling pathway in mice. | Zhang X et al. | β | 2024 | β |
| Study of decreased serum levels of C1q/TNF-related protein 4 (CTRP4) in major depressive disorder. | Chen Q et al. | β | 2024 | β |
| Adipokine C1q/Tumor Necrosis Factor- Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation Via Sirtuin 1/NF-ΞΊB Signaling. | Yu H et al. | β | 2023 | β |
| Adipokines in glucose and lipid metabolism. | Wang X et al. | β | 2023 | β |
| Circulating Levels of C1q/TNF-Related Protein 3 (CTRP3) and CTRP9 in Gestational Diabetes and Their Association with Insulin Resistance and Inflammatory Cytokines. | Fadaei R et al. | β | 2023 | β |
| Complement 1q/Tumor Necrosis Factor-Related Proteins (CTRPs): Structure, Receptors and Signaling. | Schanbacher C et al. | β | 2023 | β |
| CTRP13 ablation improves systemic glucose and lipid metabolism. | Chen F et al. | β | 2023 | β |
| Loss of CTRP10 results in female obesity with preserved metabolic health | Chen F et al. | β | 2023 | β |
| Adipocyte-Derived CTRP3 Exhibits Anti-Inflammatory Effects via LAMP1-STAT3 Axis in Psoriasis. | Xue K et al. | β | 2022 | β |
| C1QTNF3 is Upregulated During Subcutaneous Adipose Tissue Remodeling and Stimulates Macrophage Chemotaxis and M1-Like Polarization. | Micallef P et al. | β | 2022 | β |
| C1q/tumour necrosis factor-related protein-3 alleviates high-glucose-induced lipid accumulation and necroinflammation in renal tubular cells by activating the adenosine monophosphate-activated protein kinase pathway. | Du C et al. | β | 2022 | β |
| CTRP11 contributes modestly to systemic metabolism and energy balance. | Sarver DC et al. | β | 2022 | β |
| CTRP14 inactivation alters physical activity and food intake response to fasting and refeeding. | Sarver DC et al. | β | 2022 | β |
| Mechanisms by Which Skeletal Muscle Myokines Ameliorate Insulin Resistance. | Balakrishnan R et al. | β | 2022 | β |
| Novel Adipokines CTRP1, CTRP9, and FGF21 in Pediatric Type 1 and Type 2 Diabetes: A Cross-Sectional Analysis. | Arking A et al. | β | 2022 | β |
| Transgenic overexpression of CTRP3 does not prevent alcohol induced hepatic steatosis in female mice. | Thomas KL et al. | β | 2022 | β |
| Anti-Inflammatory Effects of C1q/Tumor Necrosis Factor-Related Protein 3 (CTRP3) in Endothelial Cells. | Schmid A et al. | β | 2021 | β |
| C1q/TNF-Related Protein 3 (CTRP-3) Deficiency of Adipocytes Affects White Adipose Tissue Mass but Not Systemic CTRP-3 Concentrations. | Schmid A et al. | β | 2021 | β |
| Comparative Analysis of CTRP-Mediated Effects on Cardiomyocyte Glucose Metabolism: Cross Talk between AMPK and Akt Signaling Pathway. | Li L et al. | β | 2021 | β |
| CTRP3 ameliorates fructose-induced metabolic associated fatty liver disease via inhibition of xanthine oxidase-associated oxidative stress. | Zhang J et al. | β | 2021 | β |
| CTRP3 exacerbates tendinopathy by dysregulating tendon stem cell differentiation and altering extracellular matrix composition. | Cho Y et al. | β | 2021 | β |
| CTRP3 promotes TNF-Ξ±-induced apoptosis and barrier dysfunction in salivary epithelial cells. | Mei M et al. | β | 2021 | β |
| CTRP-3 Regulates NOD1-mediated Inflammation and NOD1 Expression in Adipocytes and Adipose Tissue. | Schmid A et al. | β | 2021 | β |
| CTRP4 ablation impairs associative learning and memory. | Sarver DC et al. | β | 2021 | β |
| Isolation and identification of goose skeletal muscle satellite cells and preliminary study on the function of C1q and tumor necrosis factor-related protein 3 gene. | Wang H et al. | β | 2021 | β |
| Novel insights into the pathological mechanisms of metabolic related dyslipidemia. | Su X et al. | β | 2021 | β |
| Pathology of metabolically-related dyslipidemia. | Su X et al. | β | 2021 | β |
| Adipokines as novel biomarkers of cardio-metabolic disorders. | Su X et al. | β | 2020 | β |
| Circulating complement-1q tumor necrosis factor-Ξ±-related protein isoformΒ 5 levels are low in typeΒ 2 diabetes patients and reduced by dapagliflozin. | Zhang C et al. | β | 2020 | β |
| CTRP12 ablation differentially affects energy expenditure, body weight, and insulin sensitivity in male and female mice. | Tan SY et al. | β | 2020 | β |
| CTRP12 inhibits triglyceride synthesis and export in hepatocytes by suppressing HNF-4Ξ± and DGAT2 expression. | Tan SY et al. | β | 2020 | β |
| CTRP3 and serum triglycerides in children aged 7-10 years. | Alamian A et al. | β | 2020 | β |
| CTRP3 Regulates Endochondral Ossification and Bone Remodeling During Fracture Healing. | Youngstrom DW et al. | β | 2020 | β |
| Deficiency of C1q/TNF-related protein 3 (CTRP3) decreases adipose tissue weight in diet-induced obesity mice. | Maeda T et al. | β | 2020 | β |
| Downregulation of CTRP-3 by Weight Loss In Vivo and by Bile Acids and Incretins in Adipocytes In Vitro. | Schmid A et al. | β | 2020 | β |
| Late-onset renal hypertrophy and dysfunction in mice lacking CTRP1. | Rodriguez S et al. | β | 2020 | β |
| Loss of CTRP4 alters adiposity and food intake behaviors in obese mice. | Sarver DC et al. | β | 2020 | β |
| MiR-144 affects proliferation and apoptosis of high glucose-induced AC16 cardiomyocytes by regulating CTRP3/JNK signaling. | Song Y et al. | β | 2020 | β |
| New Insights Into Implications of CTRP3 in Obesity, Metabolic Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic Interventions. | Guo B et al. | β | 2020 | β |
| The C1q/TNF-related proteins (CTRPs) in pathogenesis of obesity-related metabolic disorders: Focus on type 2 diabetes and cardiovascular diseases. | Shanaki M et al. | β | 2020 | β |
| C1q/TNF-related protein 2 (CTRP2) deletion promotes adipose tissue lipolysis and hepatic triglyceride secretion. | Lei X et al. | β | 2019 | β |
| C1q-tumour necrosis factor-related protein-3 exacerbates cardiac hypertrophy in mice. | Ma ZG et al. | β | 2019 | β |
| CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model. | Wang K et al. | β | 2019 | β |
| Decreased CTRP3 Plasma Concentrations Are Associated with Sepsis and Predict Mortality in Critically Ill Patients. | Yagmur E et al. | β | 2019 | β |
| High molecular weight, but not total, CTRP3 levels are associated with serum triglyceride levels. | Trogen G et al. | β | 2019 | β |
| Myonectin deletion promotes adipose fat storage and reduces liver steatosis. | Little HC et al. | β | 2019 | β |
| N-Linked Glycosylation-Dependent and -Independent Mechanisms Regulating CTRP12 Cleavage, Secretion, and Stability. | Stewart AN et al. | β | 2019 | β |
| Serum CTRP3 Levels In Obese Children: A Potential Protective Adipokine Of Obesity, Insulin Sensitivity And Pancreatic Ξ² Cell Function. | Chen T et al. | β | 2019 | β |
| C1QTNF3 in the murine ovary and its function in folliculogenesis. | Mao Z et al. | β | 2018 | β |
| Calcium and vitamin D<sub>3</sub> combinations improve fatty liver disease through AMPK-independent mechanisms. | Shojaei Zarghani S et al. | β | 2018 | β |
| Low serum CTRP3 levels are associated with nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. | Zhang J et al. | β | 2018 | β |
| Serum CTRP3 level is inversely associated with nonalcoholic fatty liver disease: A 3-y longitudinal study. | Zhou W et al. | β | 2018 | β |
| Short-Term Impact of Laparoscopic Sleeve Gastrectomy on Serum Cartonectin and Vaspin Levels in Obese Subjects. | Ibrahim DM et al. | β | 2018 | β |
| The adipokine C1q TNF related protein 3 (CTRP3) is elevated in the breast milk of obese mothers. | Kwon MR et al. | β | 2018 | β |
| The Eeffect of Metformin Combined with Calcium-Vitamin D<sub>3</sub> Against Diet-Induced Nonalcoholic Fatty Liver Disease. | Shojaei Zarghani S et al. | β | 2018 | β |
| The role of adipokines in skeletal muscle inflammation and insulin sensitivity. | Nicholson T et al. | β | 2018 | β |
| The sex specific effect of alcohol consumption on circulating levels of CTRP3. | DeGroat AR et al. | β | 2018 | β |
| Transgenic overexpression of CTRP3 prevents alcohol-induced hepatic triglyceride accumulation. | Trogen G et al. | β | 2018 | β |
| Adipocyte C1QTNF5 expression is BMI-dependently related to early adipose tissue dysfunction and systemic CTRP5 serum levels in obese children. | Schwartze JT et al. | β | 2017 | β |
| C1q/TNF-Related Protein 3 (CTRP3) Function and Regulation. | Li Y et al. | β | 2017 | β |
| C1q/TNF-related protein 3 expression and effects on adipocyte differentiation of 3T3-L1 cells. | Nishimoto H et al. | β | 2017 | β |
| C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance. | Lei X et al. | β | 2017 | β |
| C1q/Tumor necrosis factor-related protein-3 protects macrophages against LPS-induced lipid accumulation, inflammation and phenotype transition via PPARΞ³ and TLR4-mediated pathways. | Lin J et al. | β | 2017 | β |
| CTRP3 attenuates cardiac dysfunction, inflammation, oxidative stress and cell death in diabetic cardiomyopathy in rats. | Ma ZG et al. | β | 2017 | β |
| CTRP7 deletion attenuates obesity-linked glucose intolerance, adipose tissue inflammation, and hepatic stress. | Petersen PS et al. | β | 2017 | β |
| Globular CTRP3 promotes mitochondrial biogenesis in cardiomyocytes through AMPK/PGC-1Ξ± pathway. | Zhang CL et al. | β | 2017 | β |
| A brief glimpse at CTRP3 and CTRP9 in lipid metabolism and cardiovascular protection. | Yang Y et al. | β | 2016 | β |
| C1q and tumor necrosis factor-related protein 3 is present in human cord blood and is associated with fetal growth. | Chen NN et al. | β | 2016 | β |
| C1q/TNF-Related Protein-9 (CTRP9) Levels Are Associated With Obesity and Decrease Following Weight Loss Surgery. | Wolf RM et al. | β | 2016 | β |
| CTRP3 deficiency reduces liver size and alters IL-6 and TGFΞ² levels in obese mice. | Wolf RM et al. | β | 2016 | β |
| CTRP3 promotes energy production by inducing mitochondrial ROS and up-expression of PGC-1Ξ± in vascular smooth muscle cells. | Feng H et al. | β | 2016 | β |
| Identification of Putative Receptors for the Novel Adipokine CTRP3 Using Ligand-Receptor Capture Technology. | Li Y et al. | β | 2016 | β |
| Immunomodulatory roles of CTRP3 in endotoxemia and metabolic stress. | Petersen PS et al. | β | 2016 | β |
| Loss of CTRP1 disrupts glucose and lipid homeostasis. | Rodriguez S et al. | β | 2016 | β |
| Loss of CTRP5 improves insulin action and hepatic steatosis. | Lei X et al. | β | 2016 | β |
| Partial deficiency of CTRP12 alters hepatic lipid metabolism. | Tan SY et al. | β | 2016 | β |
| Plasma C1q/TNF-Related Protein-3 (CTRP-3) and High-Mobility Group Box-1 (HMGB-1) Concentrations in Subjects with Prediabetes and Type 2 Diabetes. | Wei H et al. | β | 2016 | β |
| CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation. | Wu D et al. | β | 2015 | β |
| CTRP3 Stimulates Proliferation and Anti-Apoptosis of Prostate Cells through PKC Signaling Pathways. | Hou Q et al. | β | 2015 | β |
| GLP-1 receptor agonist increases the expression of CTRP3, a novel adipokine, in 3T3-L1 adipocytes through PKA signal pathway. | Li X et al. | β | 2015 | β |
| Lower Circulating C1q/TNF-Related Protein-3 (CTRP3) Levels Are Associated with Obesity: A Cross-Sectional Study. | Wolf RM et al. | β | 2015 | β |
| The association of circulating levels of complement-C1q TNF-related protein 5 (CTRP5) with nonalcoholic fatty liver disease and type 2 diabetes: a case-control study. | Emamgholipour S et al. | β | 2015 | β |
| Thromboxane synthase deficiency improves insulin action and attenuates adipose tissue fibrosis. | Lei X et al. | β | 2015 | β |
| Transcriptomic analysis of hepatic responses to testosterone deficiency in miniature pigs fed a high-cholesterol diet. | Cai Z et al. | β | 2015 | β |
| C1q/TNF-related protein-3 (CTRP-3) attenuates lipopolysaccharide (LPS)-induced systemic inflammation and adipose tissue Erk-1/-2 phosphorylation in mice in vivo. | Schmid A et al. | β | 2014 | β |
| C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight. | Byerly MS et al. | β | 2014 | β |
| CTRP2 overexpression improves insulin and lipid tolerance in diet-induced obese mice. | Peterson JM et al. | β | 2014 | β |
| Expression of CTRP3, a novel adipokine, in rats at different pathogenic stages of type 2 diabetes mellitus and the impacts of GLP-1 receptor agonist on it. | Li X et al. | β | 2014 | β |
| Free fatty acids and IL-6 induce adipocyte galectin-3 which is increased in white and brown adipose tissues of obese mice. | Krautbauer S et al. | β | 2014 | β |
| Low serum cartonectin/CTRP3 concentrations in newly diagnosed type 2 diabetes mellitus: in vivo regulation of cartonectin by glucose. | Ban B et al. | β | 2014 | β |
| Metabolic function of the CTRP family of hormones. | Seldin MM et al. | β | 2014 | β |
| Seasonal oscillation of liver-derived hibernation protein complex in the central nervous system of non-hibernating mammals. | Seldin MM et al. | β | 2014 | β |
| Targeted deletion of C1q/TNF-related protein 9 increases food intake, decreases insulin sensitivity, and promotes hepatic steatosis in mice. | Wei Z et al. | β | 2014 | β |
| CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction. | Peterson JM et al. | β | 2013 | β |
| Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. | Seldin MM et al. | β | 2013 | β |