Predictors of Patterns of Alcohol-Related Blackouts Over Time in Youth From the Collaborative Study of the Genetics of Alcoholism: The Roles of Genetics and Cannabis.
- Authors
- Schuckit, Marc A; Smith, Tom L; Shafir, Alexandra; Clausen, Peyton; Danko, George; Gonçalves, Priscila Dib; Anthenelli, Robert M; Chan, Grace; Kuperman, Samuel; Hesselbrock, Michie; Hesselbrock, Victor; Kramer, John; Bucholz, Kathleen K
- Year
- 2017
- Journal
- Journal of studies on alcohol and drugs
- PMID
- 27936363
- DOI
- 10.15288/jsad.2017.78.39
- PMCID
- PMC5148748
OBJECTIVE: Alcohol-related blackouts (ARBs) are anterograde amnesias related to heavy alcohol intake seen in about 50% of drinkers. Although a major determinant of ARBs relates to blood alcohol concentrations, additional contributions come from genetic vulnerabilities and possible impacts of cannabis use disorders (CUDs). We evaluated relationships of genetics and cannabis use to latent class trajectories of ARBs in 829 subjects from the Collaborative Study of the Genetics of Alcoholism (COGA). METHOD: The number of ARBs experienced every 2 years from subjects with average ages of 18 to 25 were entered into a latent class growth analysis in Mplus, and resulting class membership was evaluated in light of baseline characteristics, including CUDs. Correlations of number of ARBs across assessments were also compared for sibling pairs versus unrelated subjects. RESULTS: Latent class growth analysis identified ARB-based Classes 1 (consistent low = 42.5%), 2 (moderate low = 28.3%), 3 (moderate high = 22.9%), and 4 (consistent high = 6.3%). A multinomial logistic regression analysis within latent class growth analysis revealed that baseline CUDs related most closely to Classes 3 and 4. The number of ARBs across time correlated .23 for sibling pairs and -.10 for unrelated subjects. CONCLUSIONS: Baseline CUDs related to the most severe latent ARB course over time, even when considered along with other trajectory predictors, including baseline alcohol use disorders and maximum number of drinks. Data indicated significant roles for genetic factors for alcohol use disorder patterns over time. Future research is needed to improve understanding of how cannabis adds to the ARB risk and to find genes that contribute to risks for ARBs among drinkers.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | 2018 | 29623680 |
External
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| Associations of cannabis, alcohol, and tobacco use combinations with sleep health. | Reichenberger DA et al. | — | 2026 | → |
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| Factors that increase risk for alcohol-induced blackouts in high-intensity drinking young adults. | Merrill JE et al. | — | 2025 | → |
| A longitudinal study of the relationship between alcohol-related blackouts and attenuated structural brain development. | Lorkiewicz SA et al. | — | 2024 | → |
| Latent Trajectories of Persistence of Cannabis Use Across Four Decades in 329 Men From the San Diego Prospective Study. | Schuckit MA et al. | — | 2024 | → |
| Associations between blackout drinking and self-reported everyday cognition among young adults. | Linden-Carmichael AN et al. | — | 2023 | → |
| Past year high-intensity drinking moderates the association between simultaneous alcohol and marijuana use and blackout frequency among college students. | Davis CN et al. | — | 2023 | → |
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| A Longitudinal Examination of Alcohol-Related Blackouts as a Predictor of Changes in Learning, Memory, and Executive Function in Adolescents. | Lorkiewicz SA et al. | — | 2022 | → |
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| Trajectories of alcohol-induced blackouts in adolescence: early risk factors and alcohol use disorder outcomes in early adulthood. | Yuen WS et al. | — | 2021 | → |
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| Alcohol-induced blackouts, subjective intoxication, and motivation to decrease drinking: Prospective examination of the transition out of college. | Marino EN et al. | — | 2018 | → |
| Alcohol-related blackouts among college students: impact of low level of response to alcohol, ethnicity, sex, and environmental characteristics. | Gonçalves PD et al. | — | 2018 | → |
| Drinking Status Between Ages 50 and 55 for Men From the San Diego Prospective Study Who Developed DSM-IV Alcohol Abuse or Dependence in Prior Follow-Ups. | Gonçalves PD et al. | — | 2017 | → |
| Alcohol-related blackouts across 55 weeks of college: Effects of European-American ethnicity, female sex, and low level of response to alcohol. | Schuckit MA et al. | — | 2016 | → |