Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens.
paper
Cited
Public
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- Authors
- Jerlhag, Elisabet; Egecioglu, Emil; Dickson, Suzanne L; Douhan, Annika; Svensson, Lennart; Engel, JΓΆrgen A
- Year
- 2007
- Journal
- Addiction biology
- PMID
- 17407492
- DOI
- 10.1111/j.1369-1600.2006.00041.x
Ghrelin stimulates appetite, increases food intake and causes adiposity by mechanisms that include direct actions on the brain. Previously, we showed that intracerebroventricular administration of ghrelin has stimulatory and dopamine-enhancing properties. These effects of ghrelin are mediated via central nicotine receptors, suggesting that ghrelin can activate the acetylcholine-dopamine reward link. This reward link consists of cholinergic input from the laterodorsal tegmental area (LDTg) to the mesolimbic dopamine system that originates in the ventral tegmental area (VTA) and projects to the nucleus accumbens. Given that growth hormone secretagogue receptors (GHSR-1A) are expressed in the VTA and LDTg, brain areas involved in reward, the present series of experiments were undertaken to examine the hypothesis that these regions may mediate the stimulatory and dopamine-enhancing effects of ghrelin, by means of locomotor activity and in vivo microdialysis in freely moving mice. We found that local administration of ghrelin into the VTA (1 microg in 1 microl) induced an increase in locomotor activity and in the extracellular concentration of accumbal dopamine. In addition, local administration of ghrelin into the LDTg (1 microg in 1 microl) caused a locomotor stimulation and an increase in the extracellular levels of accumbal dopamine. Taken together, this indicates that ghrelin might, via activation of GHSR-1A in the VTA and LDTg, stimulate the acetylcholine-dopamine reward link, implicating that ghrelin is a part of the neurochemical overlap between the reward systems and those that regulate energy balance.
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| GHSR agonism increases blood glucose but delays food intake in GHSR hyperresponsive rats. | Zizzari P et al. | β | 2026 | β |
| Pharmacokinetic and pharmacodynamic results from a randomized controlled study with the growth hormone secretagogue receptor blocker PF-5190457 in recently abstinent patients with alcohol use disorder. | Tyler RE et al. | β | 2026 | β |
| An Emerging Role for Gut-Brain Signaling Involving Ghrelin in Chronic Stress. | Salcido AA et al. | β | 2025 | β |
| Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in Rats. | Ayman J et al. | β | 2025 | β |
| Environmental enrichment attenuates reinstatement of heroin seeking and reverses heroin-induced upregulation of mesolimbic ghrelin receptors. | Vashisht A et al. | β | 2025 | β |
| Food reward entrainment increases mealtime anxiety in goldfish via a ghrelin-dependent mechanism. | Herrera-Castillo L et al. | β | 2025 | β |
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| Long-Term Supplementation of GABA Regulates Growth, Food Intake, Locomotion, and Lipid Metabolism by Increasing Ghrelin and Growth Hormone in Adolescent Mice. | Begazo-Jimenez R et al. | β | 2025 | β |
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| Neuropsychiatric Abnormalities in Metabolic Disturbances: Interplay of Adipokines and Neurotransmission. | Cheon SY et al. | β | 2025 | β |
| Novel potential pharmacological approaches in treating eating disorders comorbid with substance use disorders. | Xi ZX et al. | β | 2025 | β |
| The (dys)regulation of energy storage in obesity. | Levin BE et al. | β | 2025 | β |
| Alcohol and the dopamine system. | SΓΆderpalm B et al. | β | 2024 | β |
| A randomized, double-blind, placebo-controlled study of a GHSR blocker in people with alcohol use disorder. | Faulkner ML et al. | β | 2024 | β |
| Decoding the influence of central LEAP2 on food intake and its effect on accumbal dopamine release. | Tufvesson-Alm M et al. | β | 2024 | β |
| Experimental biology can inform our understanding of food insecurity. | Wilbrecht L et al. | β | 2024 | β |
| Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet. | LΓ©kΓ³ AH et al. | β | 2024 | β |
| Ghrelin mediated cardioprotection using in vitro models of oxidative stress. | Kok CY et al. | β | 2024 | β |
| Ghrelin receptor antagonism and satiety attenuate Pavlovian-instrumental transfer. | Pierce-Messick ZJ et al. | β | 2024 | β |
| Ghrelin system and GLP-1 as potential treatment targets for alcohol use disorder. | Jerlhag E | β | 2024 | β |
| Gut Hormones: Possible Mediators of Addictive Disorders? | Nestor LJ et al. | β | 2024 | β |
| Hypothalamic tanycytes internalize ghrelin from the cerebrospinal fluid: Molecular mechanisms and functional implications. | Gomez IM et al. | β | 2024 | β |
| Polygenic Score Approach to Predicting Risk of Metabolic Syndrome. | Timasheva Y et al. | β | 2024 | β |
| The gut microbiota modulate locomotion via vagus-dependent glucagon-like peptide-1 signaling. | Lai TT et al. | β | 2024 | β |
| The Pathologic Roles and Therapeutic Implications of Ghrelin/GHSR System in Mental Disorders. | Mao Q et al. | β | 2024 | β |
| What influences food choices in anorexia nervosa? Disentangling cognitive and emotional components of decision-making by translational research. | Di Lodovico L et al. | β | 2024 | β |
| Animal studies reveal that the ghrelin pathway regulates alcohol-mediated responses. | Jerlhag E | β | 2023 | β |
| Chronic food restriction in mice and increased systemic ghrelin induce preference for running wheel activity. | Tezenas du Montcel C et al. | β | 2023 | β |
| Ghrelin activates the mesolimbic dopamine system via nitric oxide associated mechanisms in the ventral tegmental area. | Engel JA et al. | β | 2023 | β |
| Ghrelin Amplifies the Nicotine-Induced Release of Dopamine in the Bed Nucleus of Stria Terminalis (BNST). | Ayman J et al. | β | 2023 | β |
| Ghrelin Predicts Stimulant and Sedative Effects of Alcohol in Heavy Drinkers. | Ralevski E et al. | β | 2023 | β |
| Ghrelin signaling in the cerebellar cortex enhances GABAergic transmission onto Purkinje cells. | Hirono M et al. | β | 2023 | β |
| Ghrelin signalling in AgRP neurons links metabolic state to the sensory regulation of AgRP neural activity | So WL et al. | β | 2023 | β |
| Ghrelin signalling in AgRP neurons links metabolic state to the sensory regulation of AgRP neural activity. | So WL et al. | β | 2023 | β |
| Metabolic hormone action in the VTA: Reward-directed behavior and mechanistic insights. | Geisler CE et al. | β | 2023 | β |
| Neuropeptides Modulate Feeding via the Dopamine Reward Pathway. | Jin R et al. | β | 2023 | β |
| Overlapping representations of food and social stimuli in mouse VTA dopamine neurons. | Willmore L et al. | β | 2023 | β |
| A closer look at alcohol-induced changes in the ghrelin system: novel insights from preclinical and clinical data. | Deschaine SL et al. | β | 2022 | β |
| Beyond appetite: Acylated ghrelin as a learning, memory and fear behavior-modulating hormone. | Reich N et al. | β | 2022 | β |
| Complexes of Ghrelin GHS-R1a, GHS-R1b, and Dopamine D<sub>1</sub> Receptors Localized in the Ventral Tegmental Area as Main Mediators of the Dopaminergic Effects of Ghrelin. | Navarro G et al. | β | 2022 | β |
| Differential effects of intra-ventral tegmental area ghrelin and glucagon-like peptide-1 on the stimulatory action of D-amphetamine and cocaine-induced ethanol intake in male Sprague Dawley rats. | Colvin KJ et al. | β | 2022 | β |
| Discovery of a functionally selective ghrelin receptor (GHSR<sub>1a</sub>) ligand for modulating brain dopamine. | Gross JD et al. | β | 2022 | β |
| Energetic demands of lactation produce an increase in the expression of growth hormone secretagogue receptor in the hypothalamus and ventral tegmental area of the rat despite a reduction in circulating ghrelin. | Wellman M et al. | β | 2022 | β |
| From "Hunger Hormone" to "It's Complicated": Ghrelin Beyond Feeding Control. | Deschaine SL et al. | β | 2022 | β |
| Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders. | Masule MV et al. | β | 2022 | β |
| Gut peptide regulation of food intake - evidence for the modulation of hedonic feeding. | Woodward ORM et al. | β | 2022 | β |
| Insight into the role of the gut-brain axis in alcohol-related responses: Emphasis on GLP-1, amylin, and ghrelin. | Tufvesson-Alm M et al. | β | 2022 | β |
| Integrative Hedonic and Homeostatic Food Intake Regulation by the Central Nervous System: Insights from Neuroimaging. | Campos A et al. | β | 2022 | β |
| Involvement of the ghrelin system in the maintenance and reinstatement of cocaine-motivated behaviors: a role of adrenergic action at peripheral Ξ²1 receptors. | You ZB et al. | β | 2022 | β |
| Mechanisms of Exercise-Induced Cardiac Remodeling Differ Between Young and Aged Hearts. | Schmitt EE et al. | β | 2022 | β |
| Obesity - A Matter of Motivation? | Hanssen R et al. | β | 2022 | β |
| Potential roles of the gut microbiota in the manifestations of drug use disorders. | Wang Z et al. | β | 2022 | β |
| The Role of Ghrelin/GHS-R1A Signaling in Nonalcohol Drug Addictions. | Sustkova-Fiserova M et al. | β | 2022 | β |
| Utility of 'substance use disorder' as a heuristic for understanding overeating and obesity. | O'Connor RM et al. | β | 2022 | β |
| Activity-based anorexia animal model: a review of the main neurobiological findings. | Spadini S et al. | β | 2021 | β |
| A ghrelin receptor antagonist reduces the ability of ghrelin, alcohol or amphetamine to induce a dopamine release in the ventral tegmental area and in nucleus accumbens shell in rats. | Edvardsson CE et al. | β | 2021 | β |
| An amylin and calcitonin receptor agonist modulates alcohol behaviors by acting on reward-related areas in the brain. | Kalafateli AL et al. | β | 2021 | β |
| An Overview of Appetite-Regulatory Peptides in Addiction Processes; From Bench to Bed Side. | Shevchouk OT et al. | β | 2021 | β |
| Assessing the role of ghrelin and the enzyme ghrelin O-acyltransferase (GOAT) system in food reward, food motivation, and binge eating behavior. | Micioni Di Bonaventura E et al. | β | 2021 | β |
| A Systematic Review and Meta-Analysis Finds Increased Blood Levels of All Forms of Ghrelin in Both Restricting and Binge-Eating/Purging Subtypes of Anorexia Nervosa. | Seidel M et al. | β | 2021 | β |
| Cannabinoid-Induced Conditioned Place Preference, Intravenous Self-Administration, and Behavioral Stimulation Influenced by Ghrelin Receptor Antagonism in Rats. | Charalambous C et al. | β | 2021 | β |
| Ghrelin ameliorates chronic obstructive pulmonary disease-associated infllammation and autophagy. | Song B et al. | β | 2021 | β |
| Ghrelin modulates dopaminergic neuron formation and attention deficit hyperactivity disorder-like behaviors: From animals to human models. | Shi X et al. | β | 2021 | β |
| Hypothalamic neuropeptides and neurocircuitries in Prader Willi syndrome. | Correa-da-Silva F et al. | β | 2021 | β |
| Neuroendocrine Peptides of the Gut and Their Role in the Regulation of Food Intake. | Schalla MA et al. | β | 2021 | β |
| The Rise and Fall of Dopamine: A Two-Stage Model of the Development and Entrenchment of Anorexia Nervosa. | Beeler JA et al. | β | 2021 | β |
| Vulnerable and Resilient Phenotypes in a Mouse Model of Anorexia Nervosa. | Beeler JA et al. | β | 2021 | β |
| Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease. | Reich N et al. | β | 2020 | β |
| Alterations in Rat Accumbens Dopamine, Endocannabinoids and GABA Content During WIN55,212-2 Treatment: The Role of Ghrelin. | Charalambous C et al. | β | 2020 | β |
| An overview of ghrelin <i>O</i>-acyltransferase inhibitors: a literature and patent review for 2010-2019. | Moose JE et al. | β | 2020 | β |
| Dopaminergic activity and exercise behavior in anorexia nervosa. | Gorrell S et al. | β | 2020 | β |
| Ghrelin and Orexin Interact to Increase Meal Size Through a Descending Hippocampus to Hindbrain Signaling Pathway. | Suarez AN et al. | β | 2020 | β |
| Impaired hormonal regulation of appetite in schizophrenia: A narrative review dissecting intrinsic mechanisms and the effects of antipsychotics. | Lis M et al. | β | 2020 | β |
| Metabolic state and value-based decision-making in acute and recovered female patients with anorexia nervosa | Bernardoni F et al. | β | 2020 | β |
| Physiological Effect of Ghrelin on Body Systems. | Akalu Y et al. | β | 2020 | β |
| Physiologic Mechanisms of Type II Diabetes Mellitus Remission Following Bariatric Surgery: a Meta-analysis and Clinical Implications. | Russel SM et al. | β | 2020 | β |
| The Good, the Bad and the Unknown Aspects of Ghrelin in Stress Coping and Stress-Related Psychiatric Disorders. | Fritz EM et al. | β | 2020 | β |
| Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa. | Duriez P et al. | β | 2020 | β |
| Voluntary exercise is motivated by ghrelin, possibly related to the central reward circuit. | Mifune H et al. | β | 2020 | β |
| Brain accessibility delineates the central effects of circulating ghrelin. | Perello M et al. | β | 2019 | β |
| Divergent associations between ghrelin and neural responsivity to palatable food in hyperphagic and hypophagic depression. | Cerit H et al. | β | 2019 | β |
| Ghrelin and food reward. | Al Massadi O et al. | β | 2019 | β |
| Ghrelin concentration as an indicator of eating-disorder risk in obese women. | Iceta S et al. | β | 2019 | β |
| Ghrelin's effects on food motivation in rats are not limited to palatable foods. | Bake T et al. | β | 2019 | β |
| Ghrelin signalling within the rat nucleus accumbens and skilled reach foraging. | Vestlund J et al. | β | 2019 | β |
| Growth hormone secretagogue receptor signalling affects high-fat intake independently of plasma levels of ghrelin and LEAP2, in a 4-day binge eating model. | Cornejo MP et al. | β | 2019 | β |
| Multi-Target Drugs Against Metabolic Disorders. | Scotti L et al. | β | 2019 | β |
| Neuro-hormonal mechanisms underlying changes in reward related behaviors following weight loss surgery: Potential pharmacological targets. | Orellana ER et al. | β | 2019 | β |
| On the Abilities of Unconscious Freudian Motivational Drives to Evoke Conscious Emotions. | Kirsch M | β | 2019 | β |
| Sleep Deprivation Selectively Upregulates an Amygdala-Hypothalamic Circuit Involved in Food Reward. | Rihm JS et al. | β | 2019 | β |
| Stress and obesity: The ghrelin connection. | Abizaid A | β | 2019 | β |
| Systematic review of the effects of acute stress in binge eating disorder. | Naish KR et al. | β | 2019 | β |
| The Role of Ghrelin in Regulating Synaptic Function and Plasticity of Feeding-Associated Circuits. | Serrenho D et al. | β | 2019 | β |
| A cannabinoid receptor antagonist attenuates ghrelin-induced activation of the mesolimbic dopamine system in mice. | Kalafateli AL et al. | β | 2018 | β |
| Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner. | Hyland L et al. | β | 2018 | β |
| Effect of vertical sleeve gastrectomy on alcohol consumption and preferences in dietary obese rats and mice: A plausible role for altered ghrelin signaling. | Orellana ER et al. | β | 2018 | β |
| Exercise training and weight loss, not always a happy marriage: single blind exercise trials in females with diverse BMI. | Jackson M et al. | β | 2018 | β |
| Exogenous ghrelin administration increases alcohol self-administration and modulates brain functional activity in heavy-drinking alcohol-dependent individuals. | Farokhnia M et al. | β | 2018 | β |
| Ghrelin is Related to Personality Differences in Reward Sensitivity and Impulsivity. | Ralevski E et al. | β | 2018 | β |
| Ghrelin mediates exercise endurance and the feeding response post-exercise. | Mani BK et al. | β | 2018 | β |
| Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires Ξ²arrestin-2. | Toth K et al. | β | 2018 | β |
| Ghrelin Recruits Specific Subsets of Dopamine and GABA Neurons of Different Ventral Tegmental Area Sub-nuclei. | Cornejo MP et al. | β | 2018 | β |
| Ghrelin regulation of glucose metabolism. | Poher AL et al. | β | 2018 | β |
| Hedonic Eating and the "Delicious Circle": From Lipid-Derived Mediators to Brain Dopamine and Back. | Coccurello R et al. | β | 2018 | β |
| Homeostatic and non-homeostatic controls of feeding behavior: Distinct vs. common neural systems. | Liu CM et al. | β | 2018 | β |
| Hungry to gamble? Ghrelin as a predictor of persistent gambling in the face of loss. | Sztainert T et al. | β | 2018 | β |
| Limited Access to a High Fat Diet Alters Endocannabinoid Tone in Female Rats. | Satta V et al. | β | 2018 | β |
| Locomotor sensitization is expressed by ghrelin and D1 dopamine receptor agonist in the nucleus accumbens core in amphetamine pre-exposed rat. | Jang JK et al. | β | 2018 | β |
| Neuroendocrinology and brain imaging of reward in eating disorders: A possible key to the treatment of anorexia nervosa and bulimia nervosa. | Monteleone AM et al. | β | 2018 | β |
| Obesity and Brain Positron Emission Tomography. | Pak K et al. | β | 2018 | β |
| On the Drive Specificity of Freudian Drives for the Generation of SEEKING Activities: The Importance of the Underestimated Imperative Motor Factor. | Kirsch M et al. | β | 2018 | β |
| The Homeostatic Force of Ghrelin. | Yanagi S et al. | β | 2018 | β |
| To Do or Not to Do: Dopamine, Affordability and the Economics of Opportunity. | Beeler JA et al. | β | 2018 | β |
| Clarifying the Ghrelin System's Ability to Regulate Feeding Behaviours Despite Enigmatic Spatial Separation of the GHSR and Its Endogenous Ligand. | Edwards A et al. | β | 2017 | β |
| Exploring the Behavioral and Metabolic Phenotype Generated by Re-Introduction of the Ghrelin Receptor in the Ventral Tegmental Area. | Skov LJ et al. | β | 2017 | β |
| From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation. | Howick K et al. | β | 2017 | β |
| Ghrelin and Neurodegenerative Disorders-a Review. | Shi L et al. | β | 2017 | β |
| Ghrelin is Supressed by Intravenous Alcohol and is Related to Stimulant and Sedative Effects of Alcohol. | Ralevski E et al. | β | 2017 | β |
| Hedonic eating in Prader-Willi syndrome is associated with blunted PYY secretion. | Rigamonti AE et al. | β | 2017 | β |
| Hunger and Satiety Gauge Reward Sensitivity. | Cassidy RM et al. | β | 2017 | β |
| Is there a role for ghrelin in central dopaminergic systems? Focus on nigrostriatal and mesocorticolimbic pathways. | Stievenard A et al. | β | 2017 | β |
| It wasn't me; it was my brain - Obesity-associated characteristics of brain circuits governing decision-making. | Horstmann A | β | 2017 | β |
| Linking Stress and Infertility: A Novel Role for Ghrelin. | Sominsky L et al. | β | 2017 | β |
| Neural and Molecular Mechanisms Involved in Controlling the Quality of Feeding Behavior: Diet Selection and Feeding Patterns. | Sasaki T | β | 2017 | β |
| Obesity: Current and potential pharmacotherapeutics and targets. | Narayanaswami V et al. | β | 2017 | β |
| Role of the gut microbiota in host appetite control: bacterial growth to animal feeding behaviour. | Fetissov SO | β | 2017 | β |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | β | 2017 | β |
| The Role of the Ghrelin System in Drug Addiction. | Zallar LJ et al. | β | 2017 | β |
| Centrally Administered Ghrelin Acutely Influences Food Choice in Rodents. | SchΓ©le E et al. | β | 2016 | β |
| Control of Appetite and Food Preference by NMDA Receptor and Its Co-Agonist d-Serine. | Sasaki T et al. | β | 2016 | β |
| Dopamine D2 gene expression interacts with environmental enrichment to impact lifespan and behavior. | Thanos PK et al. | β | 2016 | β |
| Driving the need to feed: Insight into the collaborative interaction between ghrelin and endocannabinoid systems in modulating brain reward systems. | Edwards A et al. | β | 2016 | β |
| Enhanced responsiveness of Ghsr Q343X rats to ghrelin results in enhanced adiposity without increased appetite. | Chebani Y et al. | β | 2016 | β |
| Genetic variation of the growth hormone secretagogue receptor gene is associated with alcohol use disorders identification test scores and smoking. | Suchankova P et al. | β | 2016 | β |
| Ghrelin receptor activation in the ventral tegmental area amplified instrumental responding but not the excitatory influence of Pavlovian stimuli on instrumental responding. | Sommer S et al. | β | 2016 | β |
| Ghrelin treatment prevents development of activity based anorexia in mice. | Legrand R et al. | β | 2016 | β |
| Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity. | Lee JH et al. | β | 2016 | β |
| Sub-chronic Ghrelin Receptor Blockade Attenuates Alcohol- and Amphetamine-Induced Locomotor Stimulation in Mice. | Suchankova P et al. | β | 2016 | β |
| The Neurobiological Impact of Ghrelin Suppression after Oesophagectomy. | Murphy CF et al. | β | 2016 | β |
| The role of ghrelin signalling for sexual behaviour in male mice. | Egecioglu E et al. | β | 2016 | β |
| The Stomach-Derived Hormone Ghrelin Increases Impulsive Behavior. | Anderberg RH et al. | β | 2016 | β |
| Anticipatory and consummatory effects of (hedonic) chocolate intake are associated with increased circulating levels of the orexigenic peptide ghrelin and endocannabinoids in obese adults. | Rigamonti AE et al. | β | 2015 | β |
| Argument for a non-linear relationship between severity of human obesity and dopaminergic tone. | Horstmann A et al. | β | 2015 | β |
| Diet-induced obesity causes ghrelin resistance in reward processing tasks. | Lockie SH et al. | β | 2015 | β |
| Escalation in high fat intake in a binge eating model differentially engages dopamine neurons of the ventral tegmental area and requires ghrelin signaling. | Valdivia S et al. | β | 2015 | β |
| Ghrelin. | MΓΌller TD et al. | β | 2015 | β |
| Ghrelin in psychiatric disorders - A review. | Wittekind DA et al. | β | 2015 | β |
| Ghrelin regulates phasic dopamine and nucleus accumbens signaling evoked by food-predictive stimuli. | Cone JJ et al. | β | 2015 | β |
| Ghrelin signaling in the ventral tegmental area mediates both reward-based feeding and fasting-induced hyperphagia on high-fat diet. | Wei XJ et al. | β | 2015 | β |
| Ghrelin signalling on food reward: a salient link between the gut and the mesolimbic system. | Perello M et al. | β | 2015 | β |
| Mesolimbic dopamine and its neuromodulators in obesity and binge eating. | Naef L et al. | β | 2015 | β |
| Modulation of cue-induced firing of ventral tegmental area dopamine neurons by leptin and ghrelin. | van der Plasse G et al. | β | 2015 | β |
| Palatability Can Drive Feeding Independent of AgRP Neurons. | Denis RG et al. | β | 2015 | β |
| Regulation of the mesolimbic dopamine circuit by feeding peptides. | Liu S et al. | β | 2015 | β |
| The appetite-inducing peptide, ghrelin, induces intracellular store-mediated rises in calcium in addiction and arousal-related laterodorsal tegmental neurons in mouse brain slices. | Hauberg K et al. | β | 2015 | β |
| The number of preproghrelin mRNA expressing cells is increased in mice with activity-based anorexia. | FranΓ§ois M et al. | β | 2015 | β |
| Addiction science: Uncovering neurobiological complexity. | Volkow ND et al. | β | 2014 | β |
| Alcohol: mechanisms along the mesolimbic dopamine system. | Engel JA et al. | β | 2014 | β |
| Ghrelin acts as an interface between physiological state and phasic dopamine signaling. | Cone JJ et al. | β | 2014 | β |
| Ghrelin alters the stimulatory effect of cocaine on ethanol intake following mesolimbic or systemic administration. | Cepko LC et al. | β | 2014 | β |
| Ghrelin levels after a cold pressor stress test in obese women with binge eating disorder. | Gluck ME et al. | β | 2014 | β |
| G Protein and Ξ²-arrestin signaling bias at the ghrelin receptor. | Evron T et al. | β | 2014 | β |
| Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders. | Vadnie CA et al. | β | 2014 | β |
| Intravenous ghrelin administration increases alcohol craving in alcohol-dependent heavy drinkers: a preliminary investigation. | Leggio L et al. | β | 2014 | β |
| Obesity: pathophysiology and intervention. | Zhang Y et al. | β | 2014 | β |
| Peptide YY and ghrelin predict craving and risk for relapse in abstinent smokers. | al'Absi M et al. | β | 2014 | β |
| Peripherally circulating ghrelin does not mediate alcohol-induced reward and alcohol intake in rodents. | Jerlhag E et al. | β | 2014 | β |
| Rewarding, reinforcing and incentive salient events involve orexigenic hypothalamic neuropeptides regulating mesolimbic dopaminergic neurotransmission. | Quarta D et al. | β | 2014 | β |
| The Pentapeptide RM-131 Promotes Food Intake and Adiposity in Wildtype Mice but Not in Mice Lacking the Ghrelin Receptor. | Fischer K et al. | β | 2014 | β |
| The role of ghrelin in addiction: a review. | Panagopoulos VN et al. | β | 2014 | β |
| Acute effects of a herb extract formulation and inulin fibre on appetite, energy intake and food choice. | Harrold JA et al. | β | 2013 | β |
| Central manipulation of dopamine receptors attenuates the orexigenic action of ghrelin. | Romero-PicΓ³ A et al. | β | 2013 | β |
| Different ghrelin localisation in adult human and rat endocrine pancreas. | Raghay K et al. | β | 2013 | β |
| Divergent circuitry underlying food reward and intake effects of ghrelin: dopaminergic VTA-accumbens projection mediates ghrelin's effect on food reward but not food intake. | Skibicka KP et al. | β | 2013 | β |
| Dysfunctions of leptin, ghrelin, BDNF and endocannabinoids in eating disorders: beyond the homeostatic control of food intake. | Monteleone P et al. | β | 2013 | β |
| Fasting levels of ghrelin covary with the brain response to food pictures. | Kroemer NB et al. | β | 2013 | β |
| Food reward-sensitive interaction of ghrelin and opioid receptor pathways in mesolimbic dopamine system. | Kawahara Y et al. | β | 2013 | β |
| Gastroenteric hormone responses to hedonic eating in healthy humans. | Monteleone P et al. | β | 2013 | β |
| Genetic variation of the ghrelin signalling system in individuals with amphetamine dependence. | Suchankova P et al. | β | 2013 | β |
| Ghrelin amplifies the nicotine-induced dopamine release in the rat striatum. | Palotai M et al. | β | 2013 | β |
| Ghrelin and eating behavior: evidence and insights from genetically-modified mouse models. | Uchida A et al. | β | 2013 | β |
| Ghrelin and eating disorders. | Atalayer D et al. | β | 2013 | β |
| Ghrelin and ghrelin receptor modulation of psychostimulant action. | Wellman PJ et al. | β | 2013 | β |
| Ghrelin and nicotine stimulate equally the dopamine release in the rat amygdala. | Palotai M et al. | β | 2013 | β |
| Ghrelin: central and peripheral implications in anorexia nervosa. | MΓ©quinion M et al. | β | 2013 | β |
| Ghrelin receptor (GHS-R1A) antagonism suppresses both alcohol consumption and the alcohol deprivation effect in rats following long-term voluntary alcohol consumption. | Suchankova P et al. | β | 2013 | β |
| How might circadian rhythms control mood? Let me count the ways... | McClung CA | β | 2013 | β |
| Inhibition of ghrelin O-acyltransferase attenuates food deprivation-induced increases in ingestive behavior. | Teubner BJ et al. | β | 2013 | β |
| Is it stress? The role of stress related systems in chronic food restriction-induced augmentation of heroin seeking in the rat. | Sedki F et al. | β | 2013 | β |
| Microinjection of ghrelin in the nucleus accumbens core enhances locomotor activity induced by cocaine. | Jang JK et al. | β | 2013 | β |
| Neural circuits and motivational processes for hunger. | Sternson SM et al. | β | 2013 | β |
| Obesity and addiction: neurobiological overlaps. | Volkow ND et al. | β | 2013 | β |
| Roux-en-Y gastric bypass increases intravenous ethanol self-administration in dietary obese rats. | Polston JE et al. | β | 2013 | β |
| Taking two to tango: a role for ghrelin receptor heterodimerization in stress and reward. | Schellekens H et al. | β | 2013 | β |
| The addictive dimensionality of obesity. | Volkow ND et al. | β | 2013 | β |
| The role of ghrelin signalling in second-generation antipsychotic-induced weight gain. | Zhang Q et al. | β | 2013 | β |
| Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice. | Carlini VP et al. | β | 2012 | β |
| Alcohol reward is increased after Roux-en-Y gastric bypass in dietary obese rats with differential effects following ghrelin antagonism. | Hajnal A et al. | β | 2012 | β |
| A limited role for ghrelin in heroin self-administration and food deprivation-induced reinstatement of heroin seeking in rats. | Maric T et al. | β | 2012 | β |
| Bariatric surgery and the central nervous system. | Rao RS | β | 2012 | β |
| Brain reinforcement system function is ghrelin dependent: studies in the rat using pharmacological fMRI and intracranial self-stimulation. | Wellman PJ et al. | β | 2012 | β |
| Central but not systemic administration of ghrelin induces wakefulness in mice. | Szentirmai Γ | β | 2012 | β |
| Concomitant release of ventral tegmental acetylcholine and accumbal dopamine by ghrelin in rats. | Jerlhag E et al. | β | 2012 | β |
| Contribution of the mesolimbic dopamine system in mediating the effects of leptin and ghrelin on feeding. | van Zessen R et al. | β | 2012 | β |
| Functional implications of limited leptin receptor and ghrelin receptor coexpression in the brain. | Perello M et al. | β | 2012 | β |
| Gastrointestinal regulatory peptides and central nervous system mechanisms of weight control. | Ladenheim EE | β | 2012 | β |
| Ghrelin-deficient mice have fewer orexin cells and reduced cFOS expression in the mesolimbic dopamine pathway under a restricted feeding paradigm. | Lamont EW et al. | β | 2012 | β |
| Ghrelin influences novelty seeking behavior in rodents and men. | Hansson C et al. | β | 2012 | β |
| Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in rats. | Landgren S et al. | β | 2012 | β |
| Ghrelin signalling and obesity: at the interface of stress, mood and food reward. | Schellekens H et al. | β | 2012 | β |
| Ghrelin system in alcohol-dependent subjects: role of plasma ghrelin levels in alcohol drinking and craving. | Leggio L et al. | β | 2012 | β |
| GOAT induced ghrelin acylation regulates hedonic feeding. | Davis JF et al. | β | 2012 | β |
| Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in healthy humans: a pilot study. | Monteleone P et al. | β | 2012 | β |
| Hypothalamic neuropeptides and the regulation of appetite. | Parker JA et al. | β | 2012 | β |
| Impaired wake-promoting mechanisms in ghrelin receptor-deficient mice. | Esposito M et al. | β | 2012 | β |
| Neural substrates underlying interactions between appetite stress and reward. | Menzies JR et al. | β | 2012 | β |
| Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use. | Barson JR et al. | β | 2012 | β |
| Peripheral signals modifying food reward. | Menzies JR et al. | β | 2012 | β |
| Rapid modulation of TRH and TRH-like peptide release in rat brain and peripheral tissues by ghrelin and 3-TRP-ghrelin. | Pekary AE et al. | β | 2012 | β |
| Relationship of dopamine type 2 receptor binding potential with fasting neuroendocrine hormones and insulin sensitivity in human obesity. | Dunn JP et al. | β | 2012 | β |
| Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression. | Skibicka KP et al. | β | 2012 | β |
| Role of ghrelin in the pathophysiology of eating disorders: implications for pharmacotherapy. | Cardona Cano S et al. | β | 2012 | β |
| The amygdala as a neurobiological target for ghrelin in rats: neuroanatomical, electrophysiological and behavioral evidence. | Alvarez-Crespo M et al. | β | 2012 | β |
| The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors. | Dickson SL et al. | β | 2012 | β |
| The relationship of appetitive, reproductive and posterior pituitary hormones to alcoholism and craving in humans. | Kenna GA et al. | β | 2012 | β |
| The role of ghrelin in reward-based eating. | PerellΓ³ M et al. | β | 2012 | β |
| Timing to perfection: the biology of central and peripheral circadian clocks. | Albrecht U | β | 2012 | β |
| 6-Hydroxydopamine lesions of the ventral tegmental area suppress ghrelin's ability to elicit food-reinforced behavior. | Weinberg ZY et al. | β | 2011 | β |
| Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity. | Verhagen LA et al. | β | 2011 | β |
| Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence. | Hansson C et al. | β | 2011 | β |
| Central leptin and ghrelin signalling: comparing and contrasting their mechanisms of action in the brain. | Shan X et al. | β | 2011 | β |
| Effects of 18-methoxycoronaridine on ghrelin-induced increases in sucrose intake and accumbal dopamine overflow in female rats. | McCallum SE et al. | β | 2011 | β |
| Expression of the gene encoding the ghrelin receptor in rats selected for differential alcohol preference. | Landgren S et al. | β | 2011 | β |
| Food reward functions as affected by obesity and bariatric surgery. | Shin AC et al. | β | 2011 | β |
| Food reward, hyperphagia, and obesity. | Berthoud HR et al. | β | 2011 | β |
| Gastrectomy alters emotional reactivity in rats: neurobiological mechanisms. | SalomΓ© N et al. | β | 2011 | β |
| Genetic studies on the ghrelin, growth hormone secretagogue receptor (GHSR) and ghrelin O-acyl transferase (GOAT) genes. | Liu B et al. | β | 2011 | β |
| Ghrelin and food reward: the story of potential underlying substrates. | Skibicka KP et al. | β | 2011 | β |
| Ghrelin directly targets the ventral tegmental area to increase food motivation. | Skibicka KP et al. | β | 2011 | β |
| Ghrelin mediates stress-induced food-reward behavior in mice. | Chuang JC et al. | β | 2011 | β |
| Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activity. | Pfluger PT et al. | β | 2011 | β |
| Ghrelin receptor antagonism attenuates nicotine-induced locomotor stimulation, accumbal dopamine release and conditioned place preference in mice. | Jerlhag E et al. | β | 2011 | β |
| Glutamatergic regulation of ghrelin-induced activation of the mesolimbic dopamine system. | Jerlhag E et al. | β | 2011 | β |
| Hedonic and incentive signals for body weight control. | Egecioglu E et al. | β | 2011 | β |
| How addiction happens, how change happens, and what social workers need to know to be effective facilitators of change. | Littrell J | β | 2011 | β |
| Implications from addiction research towards the understanding and treatment of obesity. | Grosshans M et al. | β | 2011 | β |
| Leptin reduces hyperactivity in an animal model for anorexia nervosa via the ventral tegmental area. | Verhagen LA et al. | β | 2011 | β |
| Motivation to obtain preferred foods is enhanced by ghrelin in the ventral tegmental area. | King SJ et al. | β | 2011 | β |
| Neurobiology driving hyperactivity in activity-based anorexia. | Adan RA et al. | β | 2011 | β |
| New frontiers in endocrinology of eating disorders. | Monteleone P | β | 2011 | β |
| Obesity, metabolic syndrome, adipocytes and vascular function: A holistic viewpoint. | Achike FI et al. | β | 2011 | β |
| Reduced locomotor responses to cocaine in ghrelin-deficient mice. | Abizaid A et al. | β | 2011 | β |
| Regulation of energy balance and body weight by the brain: a distributed system prone to disruption. | Faulconbridge LF et al. | β | 2011 | β |
| Relationship between gut and sepsis: Role of ghrelin. | Das UN | β | 2011 | β |
| Reward mechanisms in obesity: new insights and future directions. | Kenny PJ | β | 2011 | β |
| Reward-related genes and personality traits in alcohol-dependent individuals: a pilot case control study. | Landgren S et al. | β | 2011 | β |
| Role of feeding-related pathways in alcohol dependence: A focus on sweet preference, NPY, and ghrelin. | Leggio L et al. | β | 2011 | β |
| Selective reduction in neural responses to high calorie foods following gastric bypass surgery. | Ochner CN et al. | β | 2011 | β |
| SKF 83566 attenuates the effects of ghrelin on performance in the object location memory task. | Jacoby SM et al. | β | 2011 | β |
| Systemic ghrelin and reward: effect of cholinergic blockade. | Disse E et al. | β | 2011 | β |
| The alcohol-induced locomotor stimulation and accumbal dopamine release is suppressed in ghrelin knockout mice. | Jerlhag E et al. | β | 2011 | β |
| The extra-hypothalamic actions of ghrelin on neuronal function. | Andrews ZB | β | 2011 | β |
| The ghrelin signalling system is involved in the consumption of sweets. | Landgren S et al. | β | 2011 | β |
| Altered metabolic and neurochemical responses to chronic unpredictable stressors in ghrelin receptor-deficient mice. | Patterson ZR et al. | β | 2010 | β |
| Appetite and reward. | Fulton S | β | 2010 | β |
| Association between symptom improvement and change of body mass index, lipid profile, and leptin, ghrelin, and cholecystokinin levels during 6-week olanzapine treatment in patients with first-episode psychosis. | Basoglu C et al. | β | 2010 | β |
| Blockade of central nicotine acetylcholine receptor signaling attenuate ghrelin-induced food intake in rodents. | Dickson SL et al. | β | 2010 | β |
| Focus on the short- and long-term effects of ghrelin on energy homeostasis. | De Vriese C et al. | β | 2010 | β |
| Genetic variation of the ghrelin signaling system in females with severe alcohol dependence. | Landgren S et al. | β | 2010 | β |
| Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: role as regulators of food intake and body weight. | Stengel A et al. | β | 2010 | β |
| Ghrelin increases intake of rewarding food in rodents. | Egecioglu E et al. | β | 2010 | β |
| Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner. | Perello M et al. | β | 2010 | β |
| Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference. | Jerlhag E et al. | β | 2010 | β |
| Ghrelin's quick inhibition of androgen-dependent behaviors of male house mice (Mus musculus). | Shah SN et al. | β | 2010 | β |
| Ghrelin's Roles in Stress, Mood, and Anxiety Regulation. | Chuang JC et al. | β | 2010 | β |
| Heterogeneity of reward mechanisms. | Lajtha A et al. | β | 2010 | β |
| Integrating GHS into the Ghrelin System. | Veldhuis JD et al. | β | 2010 | β |
| Neuroimaging, gut peptides and obesity: novel studies of the neurobiology of appetite. | Gibson CD et al. | β | 2010 | β |
| Peripheral ghrelin enhances sweet taste food consumption and preference, regardless of its caloric content. | Disse E et al. | β | 2010 | β |
| Special issue in honor of professor Armen Galoyan. Preface. | Lajtha A | β | 2010 | β |
| The neurohormonal regulation of energy intake in relation to bariatric surgery for obesity. | Ochner CN et al. | β | 2010 | β |
| Alcoholism: a systems approach from molecular physiology to addictive behavior. | Spanagel R | β | 2009 | β |
| An animal model of compulsive food-taking behaviour. | Heyne A et al. | β | 2009 | β |
| An expanded view of energy homeostasis: neural integration of metabolic, cognitive, and emotional drives to eat. | Shin AC et al. | β | 2009 | β |
| Anorexigenic and electrophysiological actions of novel ghrelin receptor (GHS-R1A) antagonists in rats. | SalomΓ© N et al. | β | 2009 | β |
| Appetite control and energy balance regulation in the modern world: reward-driven brain overrides repletion signals. | Zheng H et al. | β | 2009 | β |
| Assessing the role of the growth hormone secretagogue receptor in motivational learning and food intake. | Johnson AW et al. | β | 2009 | β |
| Association of nAChR gene haplotypes with heavy alcohol use and body mass. | Landgren S et al. | β | 2009 | β |
| Compulsive alcohol drinking in rodents. | Vengeliene V et al. | β | 2009 | β |
| Ghrelin and dopamine: new insights on the peripheral regulation of appetite. | Abizaid A | β | 2009 | β |
| Ghrelin antagonized 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptosis in MES23.5 cells. | Dong J et al. | β | 2009 | β |
| Ghrelin gene products and the regulation of food intake and gut motility. | Chen CY et al. | β | 2009 | β |
| Ghrelin in central neurons. | Ferrini F et al. | β | 2009 | β |
| Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism. | Andrews ZB et al. | β | 2009 | β |
| Homeostatic and hedonic signals interact in the regulation of food intake. | Lutter M et al. | β | 2009 | β |
| Hormones and drinking behaviour: new findings on ghrelin, insulin, leptin and volume-regulating hormones. An ESBRA Symposium report. | Addolorato G et al. | β | 2009 | β |
| Peripherally administered ghrelin induces bimodal effects on the mesolimbic dopamine system depending on food-consumptive states. | Kawahara Y et al. | β | 2009 | β |
| Requirement of central ghrelin signaling for alcohol reward. | Jerlhag E et al. | β | 2009 | β |
| Systemic administration of ghrelin increases extracellular dopamine in the shell but not the core subdivision of the nucleus accumbens. | Quarta D et al. | β | 2009 | β |
| Targeting the ghrelin receptor to regulate food intake. | Depoortere I | β | 2009 | β |
| The anorexic agents, sibutramine and fenfluramine, depress GABA(B)-induced inhibitory postsynaptic potentials in rat mesencephalic dopaminergic cells. | Ledonne A et al. | β | 2009 | β |
| Understanding and treating alcohol craving and dependence: recent pharmacological and neuroendocrinological findings. | Leggio L | β | 2009 | β |
| Alcohol dependence is associated with reduced plasma and fundic ghrelin levels. | Badaoui A et al. | β | 2008 | β |
| Alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors are involved in mediating the ghrelin-induced locomotor stimulation and dopamine overflow in nucleus accumbens. | Jerlhag E et al. | β | 2008 | β |
| Association of pro-ghrelin and GHS-R1A gene polymorphisms and haplotypes with heavy alcohol use and body mass. | Landgren S et al. | β | 2008 | β |
| Central and peripheral regulation of food intake and physical activity: pathways and genes. | Lenard NR et al. | β | 2008 | β |
| Ghrelin in the CNS: from hunger to a rewarding and memorable meal? | Olszewski PK et al. | β | 2008 | β |
| Ghrelin modulates brain activity in areas that control appetitive behavior. | Malik S et al. | β | 2008 | β |
| Hypothalamic gene expression following ghrelin therapy to gastrectomized rodents. | Egecioglu E et al. | β | 2008 | β |
| Leptin and ghrelin levels in patients with schizophrenia during different antipsychotics treatment: a review. | Sentissi O et al. | β | 2008 | β |
| Molecular network of obesity: what does it promise for pharmacotherapy? | Myslobodsky M | β | 2008 | β |
| Neural systems controlling the drive to eat: mind versus metabolism. | Zheng H et al. | β | 2008 | β |
| Neuropharmacology of alcohol addiction. | Vengeliene V et al. | β | 2008 | β |
| Systemic administration of ghrelin induces conditioned place preference and stimulates accumbal dopamine. | Jerlhag E | β | 2008 | β |
| Systemic ghrelin sensitizes cocaine-induced hyperlocomotion in rats. | Wellman PJ et al. | β | 2008 | β |
| Alcohol administration acutely inhibits ghrelin secretion in an experiment involving psychosocial stress. | Zimmermann US et al. | β | 2007 | β |
| Eating for pleasure or calories. | Zheng H et al. | β | 2007 | β |
| Gender differences for ghrelin levels in alcohol-dependent patients and differences between alcoholics and healthy controls. | Wurst FM et al. | β | 2007 | β |
| Ghrelin: a link between energy homeostasis and drug abuse? | Cummings DE et al. | β | 2007 | β |