Genetics of aggressive behavior: An overview.
paper
Cited
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- Authors
- Veroude, Kim; Zhang-James, Yanli; Fernà ndez-Castillo, Noèlia; Bakker, Mireille J; Cormand, Bru; Faraone, Stephen V
- Year
- 2016
- Journal
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- PMID
- 26345359
- DOI
- 10.1002/ajmg.b.32364
The Research Domain Criteria (RDoC) address three types of aggression: frustrative non-reward, defensive aggression and offensive/proactive aggression. This review sought to present the evidence for genetic underpinnings of aggression and to determine to what degree prior studies have examined phenotypes that fit into the RDoC framework. Although the constructs of defensive and offensive aggression have been widely used in the animal genetics literature, the human literature is mostly agnostic with regard to all the RDoC constructs. We know from twin studies that about half the variance in behavior may be explained by genetic risk factors. This is true for both dimensional, trait-like, measures of aggression and categorical definitions of psychopathology. The non-shared environment seems to have a moderate influence with the effects of shared environment being unclear. Human molecular genetic studies of aggression are in an early stage. The most promising candidates are in the dopaminergic and serotonergic systems along with hormonal regulators. Genome-wide association studies have not yet achieved genome-wide significance, but current samples are too small to detect variants having the small effects one would expect for a complex disorder. The strongest molecular evidence for a genetic basis for aggression comes from animal models comparing aggressive and non-aggressive strains or documenting the effects of gene knockouts. Although we have learned much from these prior studies, future studies should improve the measurement of aggression by using a systematic method of measurement such as that proposed by the RDoC initiative.
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| Title | Year | PMID |
|---|---|---|
| Genetic association study of childhood aggression across raters, instruments, and age. | 2021 | 34330890 |
| Genetic influences on conduct disorder. | 2018 | 27350097 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Linking Genetics to Behavior: From Glutamatergic Genetic Variation Via Amygdala Morphology and Fear Recognition to Youths' Callous-Unemotional Traits and Reactive-Proactive Aggression. | Kleine Deters R et al. | β | 2026 | β |
| A systematic review of the etiology and neurobiology of intermittent explosive disorder. | Paliakkara J et al. | β | 2025 | β |
| Deciphering the mediating role of childhood maltreatment in the association between genetic risk and developmental trajectories of school-age reactive and proactive aggression. | Ouellet-Morin I et al. | β | 2025 | β |
| Familial aggregation of traffic risky behaviours among pedestrians: a cross-sectional study in northwestern Iran. | Davtalab Esmaeili E et al. | β | 2025 | β |
| Melatonin effects on animal behavior: circadian rhythm, stress response, and modulation of behavioral patterns. | Song Y et al. | β | 2025 | β |
| Shedding Light on Antisocial Behavior Through Genetically Informed Research. | Pezzoli P et al. | β | 2025 | β |
| The balance between care and conflict may be key to understanding maternal aggression in canaries. | Garcia-Co C et al. | β | 2025 | β |
| Enhancing aggression in Henan gamecocks via augmentation of serotonergic-dopaminergic signaling and attenuation of neuroimmune response. | Su C et al. | β | 2024 | β |
| MAOA methylation is associated with impulsive and antisocial behaviour: dependence on allelic variation, family environment and diet. | Kanarik M et al. | β | 2024 | β |
| Childhood parenting and adolescent internalizing and externalizing symptoms: Moderation by multilocus hypothalamic-pituitary-adrenal axis-related genetic variation. | Cao C et al. | β | 2023 | β |
| Direct and Indirect Genetic Effects on Aggression. | van der Laan CM et al. | β | 2023 | β |
| Genetics and epigenetics of human aggression. | Odintsova VV et al. | β | 2023 | β |
| Oppositional defiant disorder. | Hawes DJ et al. | β | 2023 | β |
| The pleiotropic contribution of genes in dopaminergic and serotonergic pathways to addiction and related behavioral traits. | AntΓ³n-Galindo E et al. | β | 2023 | β |
| Age Effects Aggressive Behavior: RNA-Seq Analysis in Cattle with Implications for Studying Neoteny Under Domestication. | Eusebi PG et al. | β | 2022 | β |
| Chromosomal-level reference genome assembly of the North American wolverine (Gulo gulo luscus): a resource for conservation genomics. | Lok S et al. | β | 2022 | β |
| Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human. | Peng SX et al. | β | 2022 | β |
| Effect of environmental enrichment on aggression and the expression of brain-derived neurotrophic factor transcript variants in group-housed male mice. | Aldhshan MS et al. | β | 2022 | β |
| Hippocampal Proteomic Analysis in Male Mice Following Aggressive Behavior Induced by Long-Term Administration of Perampanel. | Yang W et al. | β | 2022 | β |
| HTR1B genotype and psychopathy: Main effect and interaction with paternal maltreatment. | Palumbo S et al. | β | 2022 | β |
| Interaction between Sirtuin 1 (SIRT1) polymorphisms and childhood maltreatment on aggression risk in Chinese male adolescents. | Wang M et al. | β | 2022 | β |
| Polygenic risk scores for antisocial behavior in relation to amygdala morphology across an attention deficit hyperactivity disorder case-control sample with and without disruptive behavior. | Kleine Deters R et al. | β | 2022 | β |
| The Impact of Probiotic <i>Bacillus subtilis</i> on Injurious Behavior in Laying Hens. | Jiang S et al. | β | 2022 | β |
| The origins of evil: From lesions to the functional architecture of the antisocial brain. | DugrΓ© JR et al. | β | 2022 | β |
| The regulatory role of AP-2Ξ² in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential. | Al-Sabri MH et al. | β | 2022 | β |
| The Relationship between Androgen Receptor Gene Polymorphism, Aggression and Social Status in Young Men and Women. | Valenzuela NT et al. | β | 2022 | β |
| Associations of age, sex, sexual abuse, and genotype with monoamine oxidase a gene methylation. | Checknita D et al. | β | 2021 | β |
| Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course. | van der Laan CM et al. | β | 2021 | β |
| Differential expression of 10 genes in the hypothalamus of two generations of rats selected for a reaction to humans. | Klimova NV et al. | β | 2021 | β |
| From warrior genes to translational solutions: novel insights into monoamine oxidases (MAOs) and aggression. | Mentis AA et al. | β | 2021 | β |
| Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle. | Eusebi PG et al. | β | 2021 | β |
| Genetic association study of childhood aggression across raters, instruments, and age. | Ip HF et al. | β | 2021 | β |
| Induction of aberrant agonistic behavior by a combination of serotonergic and dopaminergic manipulation in rats. | Kai N et al. | β | 2021 | β |
| Is the association between childhood maltreatment and aggressive behavior mediated by hostile attribution bias in women? A discordant twin and sibling study. | Johansson A et al. | β | 2021 | β |
| Psychopathy in women: insights from neuroscience and ways forward for research. | Tully J et al. | β | 2021 | β |
| SLC25A24 gene methylation and gray matter volume in females with and without conduct disorder: an exploratory epigenetic neuroimaging study. | Farrow E et al. | β | 2021 | β |
| The Modulatory Role of Serotonin on Human Impulsive Aggression. | da Cunha-Bang S et al. | β | 2021 | β |
| A functional SNP in the synaptic <i>SNAP25</i> gene is associated with impulsivity in a Colombian sample. | GonzΓ‘lez-Giraldo Y et al. | β | 2020 | β |
| Aggression based genome-wide, glutamatergic, dopaminergic and neuroendocrine polygenic risk scores predict callous-unemotional traits. | Ruisch IH et al. | β | 2020 | β |
| Are Owls and Larks Different When it Comes to Aggression? Genetics, Neurobiology, and Behavior. | Deibel SH et al. | β | 2020 | β |
| Association between Soft Drink Consumption and Aggressive Behaviour among a Quarter Million Adolescents from 64 Countries Based on the Global School-Based Student Health Survey (GSHS). | Shi Z et al. | β | 2020 | β |
| Associations of multiple trauma types and MAOA with severe aggressive behavior and MAOA effects on training outcome. | Smeijers D et al. | β | 2020 | β |
| Intra-Group Lethal Gang Aggression in Domestic Pigs <i>(Sus scrofa domesticus)</i>. | Camerlink I et al. | β | 2020 | β |
| Monoamine and neuroendocrine gene-sets associate with frustration-based aggression in a gender-specific manner. | van Donkelaar MMJ et al. | β | 2020 | β |
| Nitric oxide synthase genotype interacts with stressful life events to increase aggression in male subjects in a population-representative sample. | O'Leary A et al. | β | 2020 | β |
| RBFOX1, encoding a splicing regulator, is a candidate gene for aggressive behavior. | FernΓ ndez-Castillo N et al. | β | 2020 | β |
| The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men. | Kolla NJ et al. | β | 2020 | β |
| Twin study of laboratory-induced aggression. | DiniΔ BM et al. | β | 2020 | β |
| Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study. | Hagenbeek FA et al. | β | 2020 | β |
| Using imputed whole-genome sequence variants to uncover candidate mutations and genes affecting milking speed and temperament in Holstein cattle. | Chen SY et al. | β | 2020 | β |
| Variants of the Aggression-Related <i>RBFOX1</i> Gene in a Population Representative Birth Cohort Study: Aggressiveness, Personality, and Alcohol Use Disorder. | Vaht M et al. | β | 2020 | β |
| An integrated analysis of genes and functional pathways for aggression in human and rodent models. | Zhang-James Y et al. | β | 2019 | β |
| Blood Testosterone Concentration and Testosterone-induced Aggressive Behavior in Male Layer Chicks: Comparison between Isolated- and Grouped-Raising. | Yan Z et al. | β | 2019 | β |
| Conduct disorder. | Fairchild G et al. | β | 2019 | β |
| Correlation between GRIK2 rs6922753, rs2227283 polymorphism and aggressive behaviors with Bipolar Mania in the Chinese Han population. | Ma H et al. | β | 2019 | β |
| Early-life adversity-induced long-term epigenetic programming associated with early onset of chronic physical aggression: Studies in humans and animals. | Chistiakov DA et al. | β | 2019 | β |
| Genetic influences on antisocial behavior: recent advances and future directions. | Gard AM et al. | β | 2019 | β |
| Genomics of human aggression: current state of genome-wide studies and an automated systematic review tool. | Odintsova VV et al. | β | 2019 | β |
| [Influence of genetic and environment factors on aggressive behavior in twin children]. | Huang XX et al. | β | 2019 | β |
| Maladaptive Aggression: With a Focus on Impulsive Aggression in Children and Adolescents. | Connor DF et al. | β | 2019 | β |
| No sex differences in the origins of covariation between social and physical aggression. | Slawinski BL et al. | β | 2019 | β |
| The influence of the OPRM1 (A118G) polymorphism on behavioral and neural correlates of aggression in healthy males. | Weidler C et al. | β | 2019 | β |
| Understanding Chronic Aggression and Its Treatment in Children and Adolescents. | Magalotti SR et al. | β | 2019 | β |
| Understanding zebrafish aggressive behavior. | Zabegalov KN et al. | β | 2019 | β |
| DRD4 methylation as a potential biomarker for physical aggression: An epigenome-wide, cross-tissue investigation. | Cecil CAM et al. | β | 2018 | β |
| Genes and Aggressive Behavior: Epigenetic Mechanisms Underlying Individual Susceptibility to Aversive Environments. | Palumbo S et al. | β | 2018 | β |
| Genetic influences on conduct disorder. | Salvatore JE et al. | β | 2018 | β |
| Pleiotropic Contribution of <i>MECOM</i> and <i>AVPR1A</i> to Aggression and Subcortical Brain Volumes. | van Donkelaar MMJ et al. | β | 2018 | β |
| Polymorphism of serotonin transporter gene in male subjects with antisocial behavior and MMA fighters. | Cherepkova EV et al. | β | 2018 | β |
| Serotonergic gene polymorphisms (5-HTTLPR, 5HTR1A, 5HTR2A), and population differences in aggression: traditional (Hadza and Datoga) and industrial (Russians) populations compared. | Butovskaya ML et al. | β | 2018 | β |
| Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response. | Montalvo-Ortiz JL et al. | β | 2018 | β |
| Two types of aggression in human evolution. | Wrangham RW | β | 2018 | β |
| Assessing the interplay between multigenic and environmental influences on adolescent to adult pathways of antisocial behaviors. | Li JJ | β | 2017 | β |
| Oppositional defiant disorder: current insight. | Ghosh A et al. | β | 2017 | β |
| Resting-State Functional Connectivity in the Human Connectome Project: Current Status and Relevance to Understanding Psychopathology. | Barch DM | β | 2017 | β |
| Comparative mRNA analysis of behavioral and genetic mouse models of aggression. | Malki K et al. | β | 2016 | β |
| Experimentally Assessed Reactive Aggression in Borderline Personality Disorder. | Kogan-Goloborodko O et al. | β | 2016 | β |
| Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder. | Brevik EJ et al. | β | 2016 | β |
| Genome-wide association study of aggressive behaviour in chicken. | Li Z et al. | β | 2016 | β |
| Neuroanatomical Abnormalities in Violent Individuals with and without a Diagnosis of Schizophrenia. | Del Bene VA et al. | β | 2016 | β |
| Transcriptome analysis of genes and gene networks involved in aggressive behavior in mouse and zebrafish. | Malki K et al. | β | 2016 | β |