Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases.
paper
Cited
Public
Unavailable
- Authors
- Irvine, G Brent; El-Agnaf, Omar M; Shankar, Ganesh M; Walsh, Dominic M
- Year
- 2008
- Journal
- Molecular medicine (Cambridge, Mass.)
- PMID
- 18368143
- DOI
- 10.2119/2007-00100.Irvine
- PMCID
- PMC2274891
Developing effective treatments for neurodegenerative diseases is one of the greatest medical challenges of the 21st century. Although many of these clinical entities have been recognized for more than a hundred years, it is only during the past twenty years that the molecular events that precipitate disease have begun to be understood. Protein aggregation is a common feature of many neurodegenerative diseases, and it is assumed that the aggregation process plays a central role in pathogenesis. In this process, one molecule (monomer) of a soluble protein interacts with other monomers of the same protein to form dimers, oligomers, and polymers. Conformation changes in three-dimensional structure of the protein, especially the formation of beta-strands, often accompany the process. Eventually, as the size of the aggregates increases, they may precipitate as insoluble amyloid fibrils, in which the structure is stabilized by the beta-strands interacting within a beta-sheet. In this review, we discuss this theme as it relates to the two most common neurodegenerative conditions-Alzheimer's and Parkinson's diseases.
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| Modeling Ξ²-sheet breaker peptides across multiple resolutions: from neurological targets to liposomal membranes. | Gul G | β | 2026 | β |
| Neurobiotech innovative strategies targeting Alzheimer's disease through therapeutic micro and macroalgae potentials. | Wagdy M et al. | β | 2026 | β |
| Poly(sarcosine)-<i>block</i>-oligo(l-tryptophan) Copolymers as Noncovalent Inhibitors of Protein Aggregation. | Kim J et al. | β | 2026 | β |
| The supramolecular architecture of amyloid fibrils formed by a human tau-derived hexapeptide VQIVYK. | FariΓ±as Lucas IDM et al. | β | 2026 | β |
| A Narrative Review of the Association Between Cataracts and Dementia. | Yu HN et al. | β | 2025 | β |
| Biofilm-Associated Amyloid Proteins Linked with the Progression of Neurodegenerative Diseases. | Singh AA et al. | β | 2025 | β |
| Biofilm Biology to Brain Health: Harnessing Microbial Wisdom to Uncover Amyloid Dissociating Bifunctional Nano Chaperones for Alzheimer's Therapeutics. | Randhawa S et al. | β | 2025 | β |
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| Comprehensive and Site-Specific Characterization of Protein N-Glycosylation in AD Samples Reveals Its Potential Roles in Protein Aggregation and Synaptic Dysfunction. | Xu X et al. | β | 2025 | β |
| Cryo-EM exposes diverse polymorphism in IAPP mutants to guide the rational design of peptide-based therapeutics. | Ooi SA et al. | β | 2025 | β |
| Differentiating Ξ±-synuclein aggregates using charge-sensitive gold nanoclusters. | Kaur H et al. | β | 2025 | β |
| Dynamic protein hydration water mediates the aggregation kinetics of amyloid Ξ² peptides at interfaces. | Ni Z et al. | β | 2025 | β |
| Exploring Indole-Based Molecules as Novel Therapeutics for Parkinson's Disease: A Comprehensive Review. | Mondal R et al. | β | 2025 | β |
| Identification of Age- and Cataract-Related Changes in High-Density Lens Protein Aggregates. | Wang Z et al. | β | 2025 | β |
| Inorganic Polyphosphate: An Emerging Regulator of Neuronal Bioenergetics and Its Implications in Neuroprotection. | Montilla M et al. | β | 2025 | β |
| Inspecting the Triazole Scaffold as Powerful Antifibril Agents against 2N4R Tau and Ξ±-Synuclein Aggregates. | Elbatrawy AA et al. | β | 2025 | β |
| Integrated Single-Cell and Spatial Transcriptomic Analysis Identifies ISR-Related Genes Driving Immune Regulation in Parkinson's Disease. | Jiang H et al. | β | 2025 | β |
| Morphological and Molecular Profiling of Amyloid-Ξ² Species in Alzheimer's Pathogenesis. | Almeida ZL et al. | β | 2025 | β |
| Natural bioactive compounds as modulators of autophagy: A herbal approach to the management of neurodegenerative diseases. | Nelson VK et al. | β | 2025 | β |
| Prion-like Properties of Short Isoforms of Human Chromatin Modifier PHC3. | Kachkin D et al. | β | 2025 | β |
| Synthesis and mechanistic investigation of short peptides as AΞ² aggregation inhibitors. | Parmar R et al. | β | 2025 | β |
| Targeting Gliomas with Beta-Amyloid-Specific Dyes: A Novel Approach for In Vivo Staining and Potential Therapeutic Applications. | Kucheryavykh L et al. | β | 2025 | β |
| The complement cascade in Alzheimer's disease: modern implications of an ancient immune protagonist. | Papavergi MT et al. | β | 2025 | β |
| The role of quinoline in the development of near-infrared fluorescent probes for diagnosis of Alzheimer's disease. | Melo L et al. | β | 2025 | β |
| Three-dimensional organotypic mouse brain slices to study Alzheimer's disease pathologies: a review. | Humpel C | β | 2025 | β |
| 3-Hydroxyanthranilic Acid Delays Paralysis in <i>Caenorhabditis elegans</i> Models of Amyloid-Beta and Polyglutamine Proteotoxicity. | Hull BT et al. | β | 2024 | β |
| A marine-derived antioxidant astaxanthin as a potential neuroprotective and neurotherapeutic agent: A review of its efficacy on neurodegenerative conditions. | AdΔ±gΓΌzel E et al. | β | 2024 | β |
| Asymmetric Michael addition catalysed by copper-amyloid complexes. | Fujieda N et al. | β | 2024 | β |
| Balance between Association and Dissociation Rate Constants Determines Morphology and Property of Amyloid Fibrils. | Nakagawa T et al. | β | 2024 | β |
| Boron: An intriguing factor in retarding Alzheimer's progression. | Das A et al. | β | 2024 | β |
| Cardiotoxicity and ROS Protection Assessment of three Structure-Related N-Acylhydrazones with Potential for the Treatment of Neurodegenerative Diseases. | Helena ES et al. | β | 2024 | β |
| CT-based volumetric measures obtained through deep learning: Association with biomarkers of neurodegeneration. | Srikrishna M et al. | β | 2024 | β |
| Decoding Neurodegeneration: A Review of Molecular Mechanisms and Therapeutic Advances in Alzheimer's, Parkinson's, and ALS. | Toader C et al. | β | 2024 | β |
| Diet-Modifiable Redox Alterations in Ageing and Cancer. | Hine C et al. | β | 2024 | β |
| Enhancing protein aggregation prediction: a unified analysis leveraging graph convolutional networks and active learning. | Sun J et al. | β | 2024 | β |
| Exploring the gut microbiome: probiotics, prebiotics, synbiotics, and postbiotics as key players in human health and disease improvement. | Kim YT et al. | β | 2024 | β |
| Fluorescence-Based Monitoring of Early-Stage Aggregation of Amyloid-Ξ², Amylin Peptide, Tau, and Ξ±-Synuclein Proteins. | Li Y et al. | β | 2024 | β |
| Formation of amyloid fibrils by the regulatory 14-3-3<i>ΞΆ</i> protein. | Ε ulskis D et al. | β | 2024 | β |
| From Brain to Muscle: The Role of Muscle Tissue in Neurodegenerative Disorders. | Duranti E et al. | β | 2024 | β |
| Glymphatic System Pathology and Neuroinflammation as Two Risk Factors of Neurodegeneration. | Szlufik S et al. | β | 2024 | β |
| Leveraging Biomaterial Platforms to Study Aging-Related Neural and Muscular Degeneration. | Hidalgo-Alvarez V et al. | β | 2024 | β |
| Machine Learning Derived Collective Variables for the Study of Protein Homodimerization in Membrane. | Majumder A et al. | β | 2024 | β |
| Membrane protein chaperone and sodium chloride modulate the kinetics and morphology of amyloid beta aggregation. | Sun C et al. | β | 2024 | β |
| Mitochondrial inorganic polyphosphate is required to maintain proteostasis within the organelle. | Da Costa RT et al. | β | 2024 | β |
| Native ion mobility-mass spectrometry reveals the binding mechanisms of anti-amyloid therapeutic antibodies. | Han Y et al. | β | 2024 | β |
| Nonadditivity in interactions between three membrane-wrapped colloidal spheres. | Azadbakht A et al. | β | 2024 | β |
| Structural insights into the disulfide isomerase and chaperone activity of TrbB of the F plasmid type IV secretion system. | Apostol AJ et al. | β | 2024 | β |
| Tau- and Ξ±-synuclein-targeted gold nanoparticles: applications, opportunities, and future outlooks in the diagnosis and therapy of neurodegenerative diseases. | Tapia-Arellano A et al. | β | 2024 | β |
| The Effect of Microwaves on Protein Structure: Molecular Dynamics Approach. | Broz M et al. | β | 2024 | β |
| The maintenance of oocytes in the mammalian ovary involves extreme protein longevity. | Harasimov K et al. | β | 2024 | β |
| Diagonal Interactions between Glutamate and Arginine Analogs with Varying Side-Chain Lengths in a Ξ²-Hairpin. | Li NZ et al. | β | 2023 | β |
| Dissecting the general mechanisms of protein cage self-assembly by coarse-grained simulations. | Su Z et al. | β | 2023 | β |
| Dynamic Properties of Adsorption Layers of ΞΊ-Casein Fibrils. | Milyaeva OY et al. | β | 2023 | β |
| Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method. | Rosenberg GM et al. | β | 2023 | β |
| Fractal nature of benzene stacking interactions | JovanoviΔ N et al. | β | 2023 | β |
| Insights into the Pathophysiology of Alzheimer's Disease and Potential Therapeutic Targets: A Current Perspective. | Rajah Kumaran K et al. | β | 2023 | β |
| In Vitro Antiglycation Potential of Erva-Baleeira (<i>Varronia curassavica</i> Jacq.). | Rodrigues WD et al. | β | 2023 | β |
| Predicting molecular properties of Ξ±-synuclein using force fields for intrinsically disordered proteins. | Pedersen KB et al. | β | 2023 | β |
| Prevention of Alzheimer's disease through diet: An exploratory review. | Bhuiyan NZ et al. | β | 2023 | β |
| Residue-specific binding of Ni(II) ions influences the structure and aggregation of amyloid beta (AΞ²) peptides. | Berntsson E et al. | β | 2023 | β |
| Screening for Novel Inhibitors of Amyloid Beta Aggregation and Toxicity as Potential Drugs for Alzheimer's Disease. | Sharari S et al. | β | 2023 | β |
| The 3-(3-oxoisoindolin-1-yl)pentane-2,4-dione (ISOAC1) as a new molecule able to inhibit Amyloid Ξ² aggregation and neurotoxicity. | Piccialli I et al. | β | 2023 | β |
| The effects of amyloid beta aggregation on neuronal transcription. | St Jean J et al. | β | 2023 | β |
| The Role of Heme and Copper in Alzheimer's Disease and Type 2 Diabetes Mellitus. | Pal I et al. | β | 2023 | β |
| The role of structural heterogeneity in the homodimerization of transmembrane proteins. | Majumder A et al. | β | 2023 | β |
| The Sherpa hypothesis: Phenotype-Preserving Disordered Proteins stabilize the phenotypes of neurons and oligodendrocytes. | Norris V et al. | β | 2023 | β |
| 1-Indanone and 1,3-indandione Derivatives as Ligands for Misfolded Ξ±-Synuclein Aggregates. | Sun X et al. | β | 2022 | β |
| Analysis of Cerebral Small Vessel Changes in AD Model Mice. | Shibly AZ et al. | β | 2022 | β |
| At the Intersection of Natural Structural Coloration and Bioengineering. | Chatterjee A | β | 2022 | β |
| Comparative Study of Protein Aggregation Propensity and Mutation Tolerance Between Naked Mole-Rat and Mouse. | Besse S et al. | β | 2022 | β |
| Eriodictyol and Homoeriodictyol Improve Memory Impairment in AΞ²<sub>25-35</sub>-Induced Mice by Inhibiting the NLRP3 Inflammasome. | Guo P et al. | β | 2022 | β |
| Identification of allosteric fingerprints of alpha-synuclein aggregates in matrix metalloprotease-1 and substrate-specific virtual screening with single molecule insights. | Kamboj S et al. | β | 2022 | β |
| In-depth mapping of protein localizations in whole tissue by micro-scaffold assisted spatial proteomics (MASP). | Ma M et al. | β | 2022 | β |
| Modulating the Fibrillization of Parathyroid-Hormone (PTH) Peptides: Azo-Switches as Reversible and Catalytic Entities. | Paschold A et al. | β | 2022 | β |
| Native Ambient Mass Spectrometry Imaging of Ligand-Bound and Metal-Bound Proteins in Rat Brain. | Sisley EK et al. | β | 2022 | β |
| Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid-Beta and Tau Aggregates in Alzheimer's Disease. | Rai H et al. | β | 2022 | β |
| On Computing Equilibrium Binding Constants for Protein-Protein Association in Membranes. | Majumder A et al. | β | 2022 | β |
| Potential Mechanisms Underlying Resistance to Dementia in Non-Demented Individuals with Alzheimer's Disease Neuropathology. | Kok FK et al. | β | 2022 | β |
| The Effects of Charged Amino Acid Side-Chain Length on Diagonal Cross-Strand Interactions between Carboxylate- and Ammonium-Containing Residues in a Ξ²-Hairpin. | Chang JY et al. | β | 2022 | β |
| Unveiling the Hidden Therapeutic Potential of Carnosine, a Molecule with a Multimodal Mechanism of Action: A Position Paper. | Caruso G | β | 2022 | β |
| Asymptomatic neurotoxicity of amyloid Ξ²-peptides (AΞ²1-42 and AΞ²25-35) on mouse embryonic stem cell-derived neural cells. | Mansor NI et al. | β | 2021 | β |
| A transition to degeneration triggered by oxidative stress in degenerative disorders. | Stern M et al. | β | 2021 | β |
| Calcium Dyshomeostasis in Alzheimer's Disease Pathogenesis. | Cascella R et al. | β | 2021 | β |
| Chemical Synthesis and Biological Applications of O-GlcNAcylated Peptides and Proteins. | Groenevelt JM et al. | β | 2021 | β |
| Collision-Based Electrochemical Detection of Lysozyme Aggregation. | Kirk KA et al. | β | 2021 | β |
| Complicity of Ξ±-synuclein oligomer and calcium dyshomeostasis in selective neuronal vulnerability in Lewy body disease. | Yamamoto K | β | 2021 | β |
| Contribution of the Commensal Microflora to the Immunological Homeostasis and the Importance of Immune-Related Drug Development for Clinical Applications. | Beutgen VM et al. | β | 2021 | β |
| Gene Therapy Strategy for Alzheimer's and Parkinson's Diseases Aimed at Preventing the Formation of Neurotoxic Oligomers in SH-SY5Y Cells. | El-Battari A et al. | β | 2021 | β |
| Gut-organ axis: a microbial outreach and networking. | Ahlawat S et al. | β | 2021 | β |
| Human RGR Gene and Associated Features of Age-Related Macular Degeneration in Models of Retina-Choriocapillaris Atrophy. | Bao X et al. | β | 2021 | β |
| Hydration of Simple Model Peptides in Aqueous Osmolyte Solutions. | Panuszko A et al. | β | 2021 | β |
| Hydrogen Bond Surrogate-Constrained Dynamic Antiparallel Ξ²-Sheets. | Reddy SS et al. | β | 2021 | β |
| Interaction of Amyloid-Ξ²-(1-42) Peptide and Its Aggregates with Lipid/Water Interfaces Probed by Vibrational Sum-Frequency Generation Spectroscopy. | Strazdaite S et al. | β | 2021 | β |
| Interaction of ApoMyoglobin with Heme-hIAPP complex. | Pal I et al. | β | 2021 | β |
| Investigating hypotheses of neurodegeneration by learning dynamical systems of protein propagation in the brain. | Garbarino S et al. | β | 2021 | β |
| Investigations into the Role of Metabolism in the Inflammatory Response of BV2 Microglial Cells. | Maher P | β | 2021 | β |
| Is pseudoexfoliation glaucoma a neurodegenerative disorder? | Padhy B et al. | β | 2021 | β |
| Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions. | MagalhΓ£es JD et al. | β | 2021 | β |
| Molecular dynamics study of water channels in natural and synthetic amyloid-Ξ² fibrils. | Natesh SR et al. | β | 2021 | β |
| Mutation-induced DNMT1 cleavage drives neurodegenerative disease. | Wang W et al. | β | 2021 | β |
| NAD<sup>+</sup> boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle. | Romani M et al. | β | 2021 | β |
| Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity. | Ghanem SS et al. | β | 2021 | β |
| Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates Ξ±-synuclein Pathology in a Mouse Model of Ξ±-Synuclein Propagation. | Tavassoly O et al. | β | 2021 | β |
| Phosphatidylserine synthase plays an essential role in glia and affects development, as well as the maintenance of neuronal function. | Park YJ et al. | β | 2021 | β |
| Structural Proteomics Methods to Interrogate the Conformations and Dynamics of Intrinsically Disordered Proteins. | Beveridge R et al. | β | 2021 | β |
| Swapping the Positions in a Cross-Strand Lateral Ion-Pairing Interaction between Ammonium- and Carboxylate-Containing Residues in a Ξ²-Hairpin. | Huang CH et al. | β | 2021 | β |
| The Therapeutic Potential of Carnosine/Anserine Supplementation against Cognitive Decline: A Systematic Review with Meta-Analysis. | Caruso G et al. | β | 2021 | β |
| A KLVFFAE-Derived Peptide Probe for Detection of Alpha-Synuclein Fibrils. | Wood A et al. | β | 2020 | β |
| Altered Brain Adiponectin Receptor Expression in the 5XFAD Mouse Model of Alzheimer's Disease. | Pratap AA et al. | β | 2020 | β |
| An interplay between immune response and neurodegenerative disease progression: An assessment using Drosophila as a model. | Dhankhar J et al. | β | 2020 | β |
| Application of yeast to studying amyloid and prion diseases. | Chernoff YO et al. | β | 2020 | β |
| Could Microwave Irradiation Cause Misfolding of Peptides? | Gladovic M et al. | β | 2020 | β |
| Counteracting role of nuclear factor erythroid 2-related factor 2 pathway in Alzheimer's disease. | Sharma V et al. | β | 2020 | β |
| Current Techniques for Investigating the Brain Extracellular Space. | Soria FN et al. | β | 2020 | β |
| Development and Application of a Chemical Probe Based on a Neuroprotective Flavonoid Hybrid for Target Identification Using Activity-Based Protein Profiling. | Gunesch S et al. | β | 2020 | β |
| Effect of Amyloid-Ξ² Monomers on Lipid Membrane Mechanical Parameters-Potential Implications for Mechanically Driven Neurodegeneration in Alzheimer's Disease. | Drabik D et al. | β | 2020 | β |
| Energy Metabolism Decline in the Aging Brain-Pathogenesis of Neurodegenerative Disorders. | BΕaszczyk JW | β | 2020 | β |
| Fluorescent indolizine derivative YI-13 detects amyloid-Ξ² monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model. | Kim D et al. | β | 2020 | β |
| Fluorinated Molecules and Nanotechnology: Future 'Avengers' against the Alzheimer's Disease? | Dabur M et al. | β | 2020 | β |
| Heptameric Peptide Interferes with Amyloid-Ξ² Aggregation by Structural Reorganization of the Toxic Oligomers. | Bhattacharyya R et al. | β | 2020 | β |
| Implications of the Human Gut-Brain and Gut-Cancer Axes for Future Nanomedicine. | Javed I et al. | β | 2020 | β |
| Mechanisms Regulating the UPS-ALS Crosstalk: The Role of Proteaphagy. | Quinet G et al. | β | 2020 | β |
| Multiplicity of Ξ±-Synuclein Aggregated Species and Their Possible Roles in Disease. | Gracia P et al. | β | 2020 | β |
| Nrf2: a dark horse in Alzheimer's disease treatment. | Osama A et al. | β | 2020 | β |
| Plasma BDNF Levels Following Transcranial Direct Current Stimulation Allow Prediction of Synaptic Plasticity and Memory Deficits in 3ΓTg-AD Mice. | Cocco S et al. | β | 2020 | β |
| SOLart: a structure-based method to predict protein solubility and aggregation. | Hou Q et al. | β | 2020 | β |
| T Cell Responses to Neural Autoantigens Are Similar in Alzheimer's Disease Patients and Age-Matched Healthy Controls. | Dhanwani R et al. | β | 2020 | β |
| The involvement of NLRP3 inflammasome in the treatment of Alzheimer's disease. | Feng YS et al. | β | 2020 | β |
| The Na<sup>+</sup>/Ca<sup>2+</sup>exchanger in Alzheimer's disease. | Pannaccione A et al. | β | 2020 | β |
| Transition metal nickel prevents Tau aggregation in Alzheimer's disease. | Gorantla NV et al. | β | 2020 | β |
| Tryptophan-galactosylamine conjugates inhibit and disaggregate amyloid fibrils of AΞ²42 and hIAPP peptides while reducing their toxicity. | Paul A et al. | β | 2020 | β |
| Aggregation of amyloid peptides into fibrils driven by nanoparticles and their curvature effect. | Li B et al. | β | 2019 | β |
| Alzheimer's Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts. | Fabiani C et al. | β | 2019 | β |
| Amyloid Oligomers, Protofibrils and Fibrils. | Siddiqi MK et al. | β | 2019 | β |
| Amyloid Protein-Induced Supramolecular Self-Assembly of Water-Soluble Platinum(II) Complexes: A Luminescence Assay for Amyloid Fibrillation Detection and Inhibitor Screening. | Law AS et al. | β | 2019 | β |
| Amyloid Self-Assembly of hIAPP8-20 via the Accumulation of Helical Oligomers, Ξ±-Helix to Ξ²-Sheet Transition, and Formation of Ξ²-Barrel Intermediates. | Sun Y et al. | β | 2019 | β |
| Amyloid Ξ² oligomers inhibit growth of human cancer cells. | Pavliukeviciene B et al. | β | 2019 | β |
| A small molecule Nec-1 directly induces amyloid clearance in the brains of aged APP/PS1 mice. | Yang SH et al. | β | 2019 | β |
| Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates. | Cunningham CN et al. | β | 2019 | β |
| Cholesterol-Recognition Motifs in Membrane Proteins. | Fantini J et al. | β | 2019 | β |
| Cytotoxic species in amyloid-associated diseases: Oligomers or mature fibrils. | Siddiqi MK et al. | β | 2019 | β |
| Effect of naturally occurring Ξ±-synuclein-antibodies on toxic Ξ±-synuclein-fragments. | Rabenstein M et al. | β | 2019 | β |
| Evolving paradigms on the interplay of mitochondrial Hsp70 chaperone system in cell survival and senescence. | Srivastava S et al. | β | 2019 | β |
| High affinity of AS1411 toward copper; its application in a sensitive aptasensor for copper detection. | Bahreyni A et al. | β | 2019 | β |
| High molecular weight amyloid Ξ²<sub>1-42</sub> oligomers induce neurotoxicity <i>via</i> plasma membrane damage. | Yasumoto T et al. | β | 2019 | β |
| InΒ vitro degradation of Ξ²-amyloid fibrils by microbial keratinase. | Ningthoujam DS et al. | β | 2019 | β |
| In vivo detection of tau fibrils and amyloid Ξ² aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy. | Calvo-Rodriguez M et al. | β | 2019 | β |
| Is Alzheimer's disease an inflammasomopathy? | Pereira CF et al. | β | 2019 | β |
| Methamphetamine persistently increases alpha-synuclein and suppresses gene promoter methylation within striatal neurons. | Biagioni F et al. | β | 2019 | β |
| Naphthoquinone Tryptophan Hybrids: A Promising Small Molecule Scaffold for Mitigating Aggregation of Amyloidogenic Proteins and Peptides. | Viswanathan GK et al. | β | 2019 | β |
| Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation. | Cai CZ et al. | β | 2019 | β |
| Naturally occurring biflavonoids with amyloid Ξ² aggregation inhibitory activity for development of anti-Alzheimer agents. | Sirimangkalakitti N et al. | β | 2019 | β |
| Oleuropein aglycone and hydroxytyrosol interfere differently with toxic AΞ²<sub>1-42</sub> aggregation. | Leri M et al. | β | 2019 | β |
| Pathways of amyloid-beta absorption and aggregation in a membranous environment. | Sahoo A et al. | β | 2019 | β |
| PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development. | Liu K et al. | β | 2019 | β |
| Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders. | Caruso G et al. | β | 2019 | β |
| Polymeric microfluidic continuous flow mixer combined with hyperspectral FT-IR imaging for studying rapid biomolecular events. | Jang H et al. | β | 2019 | β |
| Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI. | Chen L et al. | β | 2019 | β |
| Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP. | Sridharan S et al. | β | 2019 | β |
| Shaping the Nrf2-ARE-related pathways in Alzheimer's and Parkinson's diseases. | FΓ£o L et al. | β | 2019 | β |
| The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disorders. | Didonna A et al. | β | 2019 | β |
| The Role of Primary Cilia in the Crosstalk between the Ubiquitinβ»Proteasome System and Autophagy. | Wiegering A et al. | β | 2019 | β |
| Top-down Multiscale Approach To Simulate Peptide Self-Assembly from Monomers. | Zhao X et al. | β | 2019 | β |
| Trazodone use and risk of dementia: A population-based cohort study. | Brauer R et al. | β | 2019 | β |
| Various AKIP1 expression levels affect its subcellular localization but have no effect on NF-kappaB activation. | KeprovΓ‘ A et al. | β | 2019 | β |
| Ξ±-Synuclein oligomers mediate the aberrant form of spike-induced calcium release from IP<sub>3</sub> receptor. | Yamamoto K et al. | β | 2019 | β |
| Amyloids of multiple species: are they helpful in survival? | Upadhyay A et al. | β | 2018 | β |
| A Sensitive High-Throughput Screening Method for Identifying Small Molecule Stimulators of the Core Particle of the Proteasome. | Coleman RA et al. | β | 2018 | β |
| A single mutation on the human amyloid polypeptide modulates fibril growth and affects the mechanism of amyloid-induced membrane damage. | Hoffmann ARF et al. | β | 2018 | β |
| Autophagy and Alzheimer's Disease: From Molecular Mechanisms to Therapeutic Implications. | Uddin MS et al. | β | 2018 | β |
| Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function. | Lundgaard I et al. | β | 2018 | β |
| Biomolecular Assemblies: Moving from Observation to Predictive Design. | Wilson CJ et al. | β | 2018 | β |
| Computational analysis of the amino acid interactions that promote or decrease protein solubility. | Hou Q et al. | β | 2018 | β |
| Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer's disease. | Chatterjee M et al. | β | 2018 | β |
| Dementia and vagotomy in Taiwan: a population-based cohort study. | Lin SY et al. | β | 2018 | β |
| Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma. | Toth RP et al. | β | 2018 | β |
| Free Energy Landscape for Alpha-Helix to Beta-Sheet Interconversion in Small Amyloid Forming Peptide under Nanoconfinement. | Mudedla SK et al. | β | 2018 | β |
| In Silico, in Vitro, and in Vivo Evaluation of New Candidates for Ξ±-Synuclein PET Imaging. | Verdurand M et al. | β | 2018 | β |
| Intracerebroventricular streptozotocin induces impaired Barnes maze spatial memory and reduces astrocyte branching in the CA1 and CA3 hippocampal regions. | Zappa Villar MF et al. | β | 2018 | β |
| In Vitro Anti-Cholinesterase and Antioxidant Activity of Extracts of <i>Moringa oleifera</i> Plants from Rivers State, Niger Delta, Nigeria. | Nwidu LL et al. | β | 2018 | β |
| LncRNA XIST knockdown attenuates AΞ²<sub>25-35</sub>-induced toxicity, oxidative stress, and apoptosis in primary cultured rat hippocampal neurons by targeting miR-132. | Wang X et al. | β | 2018 | β |
| Long Non-Coding RNAs in Multifactorial Diseases: Another Layer of Complexity. | Cipolla GA et al. | β | 2018 | β |
| Mammalian amyloidogenic proteins promote prion nucleation in yeast. | Chandramowlishwaran P et al. | β | 2018 | β |
| Mitochondrial permeability transition pore: a potential drug target for neurodegeneration. | Kalani K et al. | β | 2018 | β |
| New Technologies for Analysis of Extracellular Vesicles. | Shao H et al. | β | 2018 | β |
| On the Neuroprotective Role of Astaxanthin: New Perspectives? | Galasso C et al. | β | 2018 | β |
| Overactive BRCA1 Affects Presenilin 1 in Induced Pluripotent Stem Cell-Derived Neurons in Alzheimer's Disease. | Wezyk M et al. | β | 2018 | β |
| Pathophysiological mechanisms linking F-box only protein 7 (FBXO7) and Parkinson's disease (PD). | Zhou ZD et al. | β | 2018 | β |
| Pathways for creation and annihilation of nanoscale biomembrane domains reveal alpha and beta-toxin nanopore formation processes. | Sarangi NK et al. | β | 2018 | β |
| Phenolic Compounds Characteristic of the Mediterranean Diet in Mitigating Microglia-Mediated Neuroinflammation. | Hornedo-Ortega R et al. | β | 2018 | β |
| Review: Neurodegenerative processes in temporal lobe epilepsy with hippocampal sclerosis: Clinical, pathological and neuroimaging evidence. | Tai XY et al. | β | 2018 | β |
| Site-specific detection of protein secondary structure using 2D IR dihedral indexing: a proposed assembly mechanism of oligomeric hIAPP. | Maj M et al. | β | 2018 | β |
| Structural Interconversion in Alzheimer's Amyloid-Ξ²(16-35) Peptide in an Aqueous Solution. | Alves NA et al. | β | 2018 | β |
| The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases. | Cremades N et al. | β | 2018 | β |
| The small heat shock protein Hsp27 binds Ξ±-synuclein fibrils, preventing elongation and cytotoxicity. | Cox D et al. | β | 2018 | β |
| The Tiny <i>Drosophila Melanogaster</i> for the Biggest Answers in Huntington's Disease. | Rosas-Arellano A et al. | β | 2018 | β |
| Yeast as a model to study protein misfolding in aged cells. | Di Gregorio SE et al. | β | 2018 | β |
| Aerosol Delivery of Curcumin Reduced Amyloid-Ξ² Deposition and Improved Cognitive Performance in a Transgenic Model of Alzheimer's Disease. | McClure R et al. | β | 2017 | β |
| Agouti Related Peptide Secreted Via Human Mesenchymal Stem Cells Upregulates Proteasome Activity in an Alzheimer's Disease Model. | Lee NK et al. | β | 2017 | β |
| A New Treatment Strategy for Parkinson's Disease through the Gut-Brain Axis: The Glucagon-Like Peptide-1 Receptor Pathway. | Kim DS et al. | β | 2017 | β |
| Antioxidant and Cytoprotective Activities of Grapevine Stilbenes. | Biais B et al. | β | 2017 | β |
| ATP-independent inhibition of amyloid beta fibrillation by the endoplasmic reticulum resident molecular chaperone GRP78. | Sakono M et al. | β | 2017 | β |
| Characterization of hydrogen bonding motifs in proteins: hydrogen elimination monitoring by ultraviolet photodissociation mass spectrometry. | Morrison LJ et al. | β | 2017 | β |
| CSF tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in APOE4-positive Alzheimer's disease. | Koch G et al. | β | 2017 | β |
| Discovery of a Tetrahydrobenzisoxazole Series of Ξ³-Secretase Modulators. | Zhao Z et al. | β | 2017 | β |
| Dosage-sensitive genes in evolution and disease. | Rice AM et al. | β | 2017 | β |
| Elucidation of insulin assembly at acidic and neutral pH: Characterization of low molecular weight oligomers. | Mawhinney MT et al. | β | 2017 | β |
| In vitro cholinesterase inhibitory activity of some plants used in Iranian traditional medicine. | Saeedi M et al. | β | 2017 | β |
| Lipopolysaccharide-induced memory impairment in rats: a model of Alzheimer's disease. | Zakaria R et al. | β | 2017 | β |
| LTP and memory impairment caused by extracellular AΞ² and Tau oligomers is APP-dependent. | Puzzo D et al. | β | 2017 | β |
| Nec-1 alleviates cognitive impairment with reduction of AΞ² and tau abnormalities in APP/PS1 mice. | Yang SH et al. | β | 2017 | β |
| Recent Progress in Alzheimer's Disease Research, Part 2: Genetics and Epidemiology. | Robinson M et al. | β | 2017 | β |
| Spreading of Pathology in Alzheimer's Disease. | Lv ZY et al. | β | 2017 | β |
| Stress-induced O-GlcNAcylation: an adaptive process of injured cells. | Martinez MR et al. | β | 2017 | β |
| The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection. | Hajieva P | β | 2017 | β |
| Two Distinct Polymorphic Folding States of Self-Assembly of the Non-amyloid-Ξ² Component Differ in the Arrangement of the Residues. | Pollock-Gagolashvili M et al. | β | 2017 | β |
| A Decade of Boon or Burden: What Has the CHIP Ever Done for Cellular Protein Quality Control Mechanism Implicated in Neurodegeneration and Aging? | Joshi V et al. | β | 2016 | β |
| Alzheimer's Disease and Medicinal Plants: An Overview. | Manoharan S et al. | β | 2016 | β |
| Ameliorative effects of amide derivatives of 1,3,4-thiadiazoles on scopolamine induced cognitive dysfunction. | Kulshreshtha A et al. | β | 2016 | β |
| Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta pores. | Arbor SC et al. | β | 2016 | β |
| Apomorphine: A potential modifier of amyloid deposition in Parkinson's disease? | Yarnall AJ et al. | β | 2016 | β |
| Common molecular mechanism of amyloid pore formation by Alzheimer's Ξ²-amyloid peptide and Ξ±-synuclein. | Di Scala C et al. | β | 2016 | β |
| Crossing the blood-brain-barrier with transferrin conjugated carbon dots: A zebrafish model study. | Li S et al. | β | 2016 | β |
| Delivering therapy to target: improving the odds for successful drug development. | Raghavan R et al. | β | 2016 | β |
| Functionally different Ξ±-synuclein inclusions yield insight into Parkinson's disease pathology. | Raiss CC et al. | β | 2016 | β |
| Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimer's Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments. | Coronas-Samano G et al. | β | 2016 | β |
| Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis. | Sergin I et al. | β | 2016 | β |
| In vitro anti-acetylcholinesterase activity of an aqueous extract of Unicaria tomentosa and in silico study of its active constituents. | Chowdhury S et al. | β | 2016 | β |
| Membrane-Induced Dichotomous Conformation of Amyloid Ξ² with the Disordered N-Terminal Segment Followed by the Stable C-Terminal Ξ² Structure. | Yagi-Utsumi M et al. | β | 2016 | β |
| Molecular Mechanism of Adult Neurogenesis and its Association with Human Brain Diseases. | Liu H et al. | β | 2016 | β |
| MpUL-multi: Software for Calculation of Amyloid Fibril Mass per Unit Length from TB-TEM Images. | Iadanza MG et al. | β | 2016 | β |
| mTOR pathway inhibition as a new therapeutic strategy in epilepsy and epileptogenesis. | Citraro R et al. | β | 2016 | β |
| Nanoscale dynamics of phospholipids reveals an optimal assembly mechanism of pore-forming proteins in bilayer membranes. | Sarangi NK et al. | β | 2016 | β |
| Novel Tacrine-Based Pyrano[3',4':5,6]pyrano[2,3-b]quinolinones: Synthesis and Cholinesterase Inhibitory Activity. | Hariri R et al. | β | 2016 | β |
| Piceatannol and Other Wine Stilbenes: A Pool of Inhibitors against Ξ±-Synuclein Aggregation and Cytotoxicity. | Temsamani H et al. | β | 2016 | β |
| Putative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer's and Parkinson's Disease. | Caruana M et al. | β | 2016 | β |
| Super-resolution Stimulated Emission Depletion-Fluorescence Correlation Spectroscopy Reveals Nanoscale Membrane Reorganization Induced by Pore-Forming Proteins. | Sarangi NK et al. | β | 2016 | β |
| Alzheimer's pathogenesis and its link to the mitochondrion. | Simoncini C et al. | β | 2015 | β |
| Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to Ξ±-synuclein aggregates. | Deeg AA et al. | β | 2015 | β |
| Autophagy in Cell Life and Cell Death. | Anding AL et al. | β | 2015 | β |
| Bacterial amyloid formation: structural insights into curli biogensis. | Van Gerven N et al. | β | 2015 | β |
| Computer simulation studies of AΞ²37-42 aggregation thermodynamics and kinetics in water and salt solution. | Yang YI et al. | β | 2015 | β |
| Do Macromolecular Crowding Agents Exert Only an Excluded Volume Effect? A Protein Solvation Study. | Mukherjee SK et al. | β | 2015 | β |
| Effect of charged amino acid side chain length on lateral cross-strand interactions between carboxylate- and guanidinium-containing residues in a Ξ²-hairpin. | Kuo HT et al. | β | 2015 | β |
| Exploring the Alzheimer amyloid-Ξ² peptide conformational ensemble: A review of molecular dynamics approaches. | Tran L et al. | β | 2015 | β |
| Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals. | Shang Z et al. | β | 2015 | β |
| Ginsenoside Rd Improves Learning and Memory Ability in APP Transgenic Mice. | Liu J et al. | β | 2015 | β |
| Human serum transferrin fibrils: nanomineralisation in bacteria and destruction of red blood cells. | Mukherjee A et al. | β | 2015 | β |
| Interfacial interaction and lateral association of cross-seeding assemblies between hIAPP and rIAPP oligomers. | Zhang M et al. | β | 2015 | β |
| Intracellular screening of a peptide library to derive a potent peptide inhibitor of Ξ±-synuclein aggregation. | Cheruvara H et al. | β | 2015 | β |
| Ionic Liquid Surfactant Mediated Structural Transitions and Self-Assembly of Bovine Serum Albumin in Aqueous Media: Effect of Functionalization of Ionic Liquid Surfactants. | Singh G et al. | β | 2015 | β |
| Oxidative stress in aging human skin. | Rinnerthaler M et al. | β | 2015 | β |
| Pathological Effects of Mutant C1QTNF5 (S163R) Expression in Murine Retinal Pigment Epithelium. | Dinculescu A et al. | β | 2015 | β |
| Polymorphic Associations and Structures of the Cross-Seeding of AΞ²1-42 and hIAPP1-37 Polypeptides. | Zhang M et al. | β | 2015 | β |
| Protein degradation and dynamic tRNA thiolation fine-tune translation at elevated temperatures. | Tyagi K et al. | β | 2015 | β |
| Protein Oxidation in Aging: Does It Play a Role in Aging Progression? | Reeg S et al. | β | 2015 | β |
| Zinc-induced structural changes of the disordered tppp/p25 inhibits its degradation by the proteasome. | Lehotzky A et al. | β | 2015 | β |
| Alzheimer's and Parkinson's diseases: an environmental proteomic point of view. | Demartini DR et al. | β | 2014 | β |
| A method for evaluating the level of soluble Ξ²-amyloid(1-40/1-42) in Alzheimer's disease based on the binding of gelsolin to Ξ²-amyloid peptides. | Yu Y et al. | β | 2014 | β |
| Amyloid fibril formation by the chain B subunit of monellin occurs by a nucleation-dependent polymerization mechanism. | Sabareesan AT et al. | β | 2014 | β |
| Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer's disease. | Dorey E et al. | β | 2014 | β |
| A relationship between the transient structure in the monomeric state and the aggregation propensities of Ξ±-synuclein and Ξ²-synuclein. | Allison JR et al. | β | 2014 | β |
| Association of aminoacyl-tRNA synthetases with cancer. | Kim D et al. | β | 2014 | β |
| Coming of age: orphan genes in plants. | Arendsee ZW et al. | β | 2014 | β |
| Dual life of TPPP/p25 evolved in physiological and pathological conditions. | OlΓ‘h J et al. | β | 2014 | β |
| Elevated levels of cerebrospinal fluid Ξ±-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers. | Aasly JO et al. | β | 2014 | β |
| Gain in toxic function of stefin B EPM1 mutants aggregates: correlation between cell death, aggregate number/size and oxidative stress. | Polajnar M et al. | β | 2014 | β |
| Identification of motives mediating alternative functions of the neomorphic moonlighting TPPP/p25. | TΕkΓ©si N et al. | β | 2014 | β |
| Impaired autophagy: a link between neurodegenerative and neuropsychiatric diseases. | Polajnar M et al. | β | 2014 | β |
| Increased protein aggregation in Zucker diabetic fatty rat brain: identification of key mechanistic targets and the therapeutic application of hydrogen sulfide. | Talaei F et al. | β | 2014 | β |
| Magmas functions as a ROS regulator and provides cytoprotection against oxidative stress-mediated damages. | Srivastava S et al. | β | 2014 | β |
| Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]Ξ±Syn transgenic mice. | Diepenbroek M et al. | β | 2014 | β |
| Pathogenic mutations within the hydrophobic domain of the prion protein lead to the formation of protease-sensitive prion species with increased lethality. | Coleman BM et al. | β | 2014 | β |
| Self-assembling properties of peptides derived from TDP-43 C-terminal fragment. | Saini A et al. | β | 2014 | β |
| Structure activity relationship of phenolic acid inhibitors of Ξ±-synuclein fibril formation and toxicity. | Ardah MT et al. | β | 2014 | β |
| The AΞ² peptide forms non-amyloid fibrils in the presence of carbon nanotubes. | Luo J et al. | β | 2014 | β |
| The relationship between amyloid structure and cytotoxicity. | Marshall KE et al. | β | 2014 | β |
| A hierarchical order within protein structures underlies large separations between strands in Ξ²-sheets. | Wathen B et al. | β | 2013 | β |
| Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. | Wagner J et al. | β | 2013 | β |
| Cerebrospinal fluid biomarkers in Parkinson disease. | Parnetti L et al. | β | 2013 | β |
| Design of stable Ξ²-sheet-based cyclic peptide assemblies assisted by metal coordination: selective homo- and heterodimer formation. | Panciera M et al. | β | 2013 | β |
| Estradiol prevents olfactory dysfunction induced by A-Ξ² 25-35 injection in hippocampus. | Bernal-MondragΓ³n C et al. | β | 2013 | β |
| Genetic influences on craving for alcohol. | Agrawal A et al. | β | 2013 | β |
| Increased generation of cyclopentenone prostaglandins after brain ischemia and their role in aggregation of ubiquitinated proteins in neurons. | Liu H et al. | β | 2013 | β |
| Inhibiting and reversing amyloid-Ξ² peptide (1-40) fibril formation with gramicidin S and engineered analogues. | Luo J et al. | β | 2013 | β |
| Mechanisms for the Insertion of Toxic, Fibril-like Ξ²-Amyloid Oligomers into the Membrane. | Jang H et al. | β | 2013 | β |
| Metabolic states following accumulation of intracellular aggregates: implications for neurodegenerative diseases. | Vazquez A | β | 2013 | β |
| Moonlighting microtubule-associated proteins: regulatory functions by day and pathological functions at night. | OlΓ‘h J et al. | β | 2013 | β |
| Oxidative stress and APO E polymorphisms in Alzheimer's disease and in mild cognitive impairment. | Chico L et al. | β | 2013 | β |
| Polymorphism complexity and handedness inversion in serum albumin amyloid fibrils. | Usov I et al. | β | 2013 | β |
| Positron emission tomography radioligands for in vivo imaging of AΞ² plaques. | Mason NS et al. | β | 2013 | β |
| Radiosynthesis and in vivo evaluation of a ΒΉβΈF-labelled styryl-benzoxazole derivative for Ξ²-amyloid targeting. | Ribeiro Morais G et al. | β | 2013 | β |
| Reciprocal induction between Ξ±-synuclein and Ξ²-amyloid in adult rat neurons. | Majd S et al. | β | 2013 | β |
| Aminonaphthalene 2-cyanoacrylate (ANCA) probes fluorescently discriminate between amyloid-Ξ² and prion plaques in brain. | Cao K et al. | β | 2012 | β |
| A molecular analysis of desiccation tolerance mechanisms in the anhydrobiotic nematode Panagrolaimus superbus using expressed sequenced tags. | Tyson T et al. | β | 2012 | β |
| Amyloid-derived peptide forms self-assembled monolayers on gold nanoparticle with a curvature-dependent Ξ²-sheet structure. | Shaw CP et al. | β | 2012 | β |
| Amyloid detection using a Peltier-based device. | Cabrera MA et al. | β | 2012 | β |
| Correlation of amyloid PET ligand florbetapir F 18 binding with AΞ² aggregation and neuritic plaque deposition in postmortem brain tissue. | Choi SR et al. | β | 2012 | β |
| Differential inhibition of Ξ±-synuclein oligomeric and fibrillar assembly in parkinson's disease model by cinnamon extract. | Shaltiel-Karyo R et al. | β | 2012 | β |
| Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia. | Jesse S et al. | β | 2012 | β |
| Differing modes of interaction between monomeric AΞ²(1-40) peptides and model lipid membranes: an AFM study. | Sheikh K et al. | β | 2012 | β |
| Distinct dimerization for various alloforms of the amyloid-beta protein: AΞ²(1-40), AΞ²(1-42), and AΞ²(1-40)(D23N). | CΓ΄tΓ© S et al. | β | 2012 | β |
| Genetic bases of stuttering: the state of the art, 2011. | Kraft SJ et al. | β | 2012 | β |
| Human stefin B normal and patho-physiological role: molecular and cellular aspects of amyloid-type aggregation of certain EPM1 mutants. | Polajnar M et al. | β | 2012 | β |
| Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein. | Nucifora LG et al. | β | 2012 | β |
| Insights into the disparate action of osmolytes and macromolecular crowders on amyloid formation. | Sukenik S et al. | β | 2012 | β |
| Interaction between pathogenic proteins in neurodegenerative disorders. | Jellinger KA | β | 2012 | β |
| Manipulation and capture of AΞ² amyloid fibrils and monomers by DC insulator gradient dielectrophoresis (DC-iGDEP). | Staton SJ et al. | β | 2012 | β |
| NSAIDs in the treatment and/or prevention of neurological disorders. | Khansari PS et al. | β | 2012 | β |
| Single-channel electrophysiology reveals a distinct and uniform pore complex formed by Ξ±-synuclein oligomers in lipid membranes. | Schmidt F et al. | β | 2012 | β |
| Sleep disturbances in Alzheimer's and Parkinson's diseases. | Rothman SM et al. | β | 2012 | β |
| Targeted imaging of activated caspase-3 in the central nervous system by a dual functional nano-device. | Liu Y et al. | β | 2012 | β |
| The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization. | Hamley IW | β | 2012 | β |
| The enhancing effect of homocysteine thiolactone on insulin fibrillation and cytotoxicity of insulin fibril. | Yousefi R et al. | β | 2012 | β |
| Toxic fibrillar oligomers of amyloid-Ξ² have cross-Ξ² structure. | Stroud JC et al. | β | 2012 | β |
| Ξ±-Synuclein mRNA and soluble Ξ±-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease. | Quinn JG et al. | β | 2012 | β |
| Amyloid peptides incorporating a core sequence from the amyloid beta peptide and gamma amino acids: relating bioactivity to self-assembly. | Castelletto V et al. | β | 2011 | β |
| Analysis of AΞ² (1-40) and AΞ² (1-42) monomer and fibrils by capillary electrophoresis. | Picou RA et al. | β | 2011 | β |
| A novel strategy for the targeted analysis of protein and peptide metabolites. | Williamson NA et al. | β | 2011 | β |
| Detection of protein aggregation in neurodegenerative diseases. | Deng HX et al. | β | 2011 | β |
| Evaluating nuclei concentration in amyloid fibrillation reactions using back-calculation approach. | Sorci M et al. | β | 2011 | β |
| Four and a half LIM protein 1 gene mutations cause four distinct human myopathies: a comprehensive review of the clinical, histological and pathological features. | Cowling BS et al. | β | 2011 | β |
| Impaired autophagy: a link between neurodegenerative diseases and progressive myoclonus epilepsies. | Polajnar M et al. | β | 2011 | β |
| Interaction between Ξ±-synuclein and other proteins in neurodegenerative disorders. | Jellinger KA | β | 2011 | β |
| Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. | OlΓ‘h J et al. | β | 2011 | β |
| Macroautophagy-generated increase of lysosomal amyloid Ξ²-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells. | Zheng L et al. | β | 2011 | β |
| Mechanisms of amyloid fibril formation--focus on domain-swapping. | Ε½erovnik E et al. | β | 2011 | β |
| Novel fluorescent trimethine cyanine dye 7519 for amyloid fibril inhibition assay. | Volkova KD et al. | β | 2011 | β |
| Phosphorylated Ξ±-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease. | Foulds PG et al. | β | 2011 | β |
| Sporadic inclusion-body myositis: conformational multifactorial ageing-related degenerative muscle disease associated with proteasomal and lysosomal inhibition, endoplasmic reticulum stress, and accumulation of amyloid-Ξ²42 oligomers and phosphorylated tau. | Askanas V et al. | β | 2011 | β |
| Sumoylation inhibits alpha-synuclein aggregation and toxicity. | Krumova P et al. | β | 2011 | β |
| The relevance of iron in the pathogenesis of Parkinson's disease. | Sian-HΓΌlsmann J et al. | β | 2011 | β |
| Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders. | Doyle KM et al. | β | 2011 | β |
| Abeta(1-40) forms five distinct amyloid structures whose beta-sheet contents and fibril stabilities are correlated. | Kodali R et al. | β | 2010 | β |
| A beta-amino acid modified heptapeptide containing a designed recognition element disrupts fibrillization of the amyloid beta-peptide. | Castelletto V et al. | β | 2010 | β |
| Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism. | Jiang M et al. | β | 2010 | β |
| Bioinorganic chemistry of Parkinson's disease: structural determinants for the copper-mediated amyloid formation of alpha-synuclein. | Binolfi A et al. | β | 2010 | β |
| Cerebrospinal fluid biomarkers for dementia with lewy bodies. | Mukaetova-Ladinska EB et al. | β | 2010 | β |
| Detection of elevated levels of Ξ±-synuclein oligomers in CSF from patients with Parkinson disease. | Tokuda T et al. | β | 2010 | β |
| Does the electrical activity of neurons contribute to the pathogenesis of Alzheimer's Disease? | Concepcion GP et al. | β | 2010 | β |
| Elucidation of amyloid beta-protein oligomerization mechanisms: discrete molecular dynamics study. | Urbanc B et al. | β | 2010 | β |
| From natural to designer self-assembling biopolymers, the structural characterisation of fibrous proteins & peptides using fibre diffraction. | Morris K et al. | β | 2010 | β |
| Genetics of Alzheimer disease. | Bekris LM et al. | β | 2010 | β |
| Influence of the solvent on the self-assembly of a modified amyloid beta peptide fragment. II. NMR and computer simulation investigation. | Hamley IW et al. | β | 2010 | β |
| Intracellular aggregation of human stefin B: confocal and electron microscopy study. | Ceru S et al. | β | 2010 | β |
| Macroautophagy is not directly involved in the metabolism of amyloid precursor protein. | Boland B et al. | β | 2010 | β |
| Macromolecular crowding converts the human recombinant PrPC to the soluble neurotoxic beta-oligomers. | Huang L et al. | β | 2010 | β |
| Measurement of the attachment and assembly of small amyloid-Ξ² oligomers on live cell membranes at physiological concentrations using single-molecule tools. | Nag S et al. | β | 2010 | β |
| Neurodegenerative diseases: exercising toward neurogenesis and neuroregeneration. | Ang ET et al. | β | 2010 | β |
| Protein beta-sheet nucleation is driven by local modular formation. | Wathen B et al. | β | 2010 | β |
| Spectroscopic Characterization of Intermolecular Interaction of Amyloid Ξ² Promoted on GM1 Micelles. | Yagi-Utsumi M et al. | β | 2010 | β |
| Stability of AΞ² (1-42) peptide fibrils as consequence of environmental modifications. | Gregori M et al. | β | 2010 | β |
| Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein. | Balducci C et al. | β | 2010 | β |
| Amyloid beta mediates memory formation. | Garcia-Osta A et al. | β | 2009 | β |
| Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease. | Sarantseva S et al. | β | 2009 | β |
| Caspase substrates and neurodegenerative diseases. | Bulat N et al. | β | 2009 | β |
| Cloning, characterization, and functional studies of a human 40-kDa catecholamine-regulated protein: implications in central nervous system disorders. | Gabriele J et al. | β | 2009 | β |
| Dissecting the potential molecular mechanisms underlying alpha-synuclein cell-to-cell transfer in Parkinson's disease. | Angot E et al. | β | 2009 | β |
| [Effect of environmental chemicals on the genes and the gene expression]. | Ueda K | β | 2009 | β |
| Functional amyloids signal their arrival. | Badtke MP et al. | β | 2009 | β |
| Immunological detection of N-formylkynurenine in oxidized proteins. | Ehrenshaft M et al. | β | 2009 | β |
| Intracellular amyloid beta interacts with SOD1 and impairs the enzymatic activity of SOD1: implications for the pathogenesis of amyotrophic lateral sclerosis. | Yoon EJ et al. | β | 2009 | β |
| Membrane topology of gp41 and amyloid precursor protein: interfering transmembrane interactions as potential targets for HIV and Alzheimer treatment. | Abad C et al. | β | 2009 | β |
| Molecular pathology of Lewy body diseases. | Beyer K et al. | β | 2009 | β |
| On the stability of the soluble amyloid aggregates. | Sahoo B et al. | β | 2009 | β |
| Phospholipids block nuclear factor-kappa B and tau phosphorylation and inhibit amyloid-beta secretion in human neuroblastoma cells. | Pandey NR et al. | β | 2009 | β |
| Recent advances in our understanding of neurodegeneration. | Jellinger KA | β | 2009 | β |
| The two-hydrophobic domain tertiary structure of reticulon proteins is critical for modulation of beta-secretase BACE1. | Kume H et al. | β | 2009 | β |
| Molecular medicine successes in neuroscience. | Schaller B et al. | β | 2008 | β |
| Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor? | Beel AJ et al. | β | 2008 | β |
| The amyloid-beta peptide of Alzheimer's disease binds Cu(I) in a linear bis-his coordination environment: insight into a possible neuroprotective mechanism for the amyloid-beta peptide. | Shearer J et al. | β | 2008 | β |