Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin.
paper
Cited
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- Authors
- Reymond, N; Borg, J P; Lecocq, E; Adelaide, J; Campadelli-Fiume, G; Dubreuil, P; Lopez, M
- Year
- 2000
- Journal
- Gene
- PMID
- 11024295
- DOI
- 10.1016/s0378-1119(00)00316-4
We have isolated nectin3/PRR3, the fourth human member of the nectin/PRR family, also described as the alpha herpes virus receptor family. Nectin/PRR members are adhesion molecules expressed at intercellular junctions. Nectin3/PRR3 is a transmembrane protein, whose extracellular region contains three Ig-like domains (V, C and C) and shares approximately 30% identity with the other members. It is mainly expressed in testis and placental tissues. SDS-PAGE analyses demonstrate that nectin3/PRR3 has a molecular weight of 83kDa. Nectin1/PRR1L and nectin2/PRR2S and L were found to be specifically expressed at the intercellular junctions. This localization is in part due to the interaction of the C-terminal part of these receptors (ended by the consensus sequence A/EXYV) and the PDZ domain of afadin. In this report we demonstrate that the nectin3/PRR3 receptor carries the A/EXYV consensus sequence and interacts in vivo with both long and short isoforms of afadin. These results suggest that the human nectin3/PRR3 is a new afadin-associated molecule.
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