Multivariate genetic analysis of sex limitation and G x E interaction.
paper
Cited
Public
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- Authors
- Neale, Michael C; RΓΈysamb, Espen; Jacobson, Kristen
- Year
- 2006
- Journal
- Twin research and human genetics : the official journal of the International Society for Twin Studies
- PMID
- 16899154
- DOI
- 10.1375/183242706778024937
- PMCID
- PMC4246510
Sex-limited expression of genetic or environmental factors occurs in two basic forms. First, the effects of a factor may be larger on one sex than on another, which is known as scalar sex limitation. Second, some factors may have an effect on one sex but not on the other, which is called nonscalar sex limitation. In the classical twin study, scalar sex-limited effects cause same-sex male and same-sex female twin correlations to differ. Nonscalar sex-limited effects would cause the correlations between opposite-sex pairs of relatives to be lower than would be expected from the correlations between relatives of the same sex. One approach to modeling such effects is to allow the genetic correlation between opposite-sex dizygotic twins to be less than one-half; another is to allow the common environment correlation for opposite-sex pairs to be less than unity. Extension of this approach to the multivariate case is not straightforward. Direct extension of the Cholesky decomposition such that each Cholesky factor is allowed to correlate less than one-half in opposite-sex pairs yields a model where the order of the variables can change the goodness-of-fit of the model. It is shown that similar problems exist with a variety of multivariate and longitudinal models, and in a variety of models of genotype x environment interaction. Several solutions to these problems are described.
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| Effects of Genetic Relatedness of Kin Pairs on Univariate ACE Model Performance. | Lyu X et al. | β | 2023 | β |
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| Sex differences in sleep quality and psychological distress: Insights from a middle-aged twin sample from Spain. | Madrid-Valero JJ et al. | β | 2023 | β |
| Sub-types of insomnia in adolescents: Insights from a quantitative/molecular twin study. | Madrid-Valero JJ et al. | β | 2023 | β |
| The role of neuroticism and pain in dental anxiety: A twin study. | Vassend O et al. | β | 2023 | β |
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| Perfectionism and Neuroticism: Evidence for a common genetic and environmental etiology. | BurcaΕ S et al. | β | 2021 | β |
| Using Multimodel Inference/Model Averaging to Model Causes of Covariation Between Variables in Twins. | Maes HH et al. | β | 2021 | β |
| A Genetically Informed Study of Neighborhoods and Health: Results From the MIDUS Twin Sample. | Robinette JW et al. | β | 2020 | β |
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| A population-based heritability estimate of bipolar disorder - In a Swedish twin sample. | Johansson V et al. | β | 2019 | β |
| Correlations between social dominance orientation and political attitudes reflect common genetic underpinnings. | KleppestΓΈ TH et al. | β | 2019 | β |
| How should we understand the absence of sex differences in the genetic and environmental origins of antisocial behavior? | Burt SA et al. | β | 2019 | β |
| Peer Alcohol Use Differentially Amplifies Genetic and Environmental Effects on Different Developmental Trajectories of Adolescent Alcohol Use. | Zheng Y et al. | β | 2019 | β |
| Type I Error Rates and Parameter Bias in Multivariate Behavioral Genetic Models. | Verhulst B et al. | β | 2019 | β |
| A Developmental Twin Study of Emotion Recognition and Its Negative Affective Clinical Correlates. | Rappaport LM et al. | β | 2018 | β |
| Childhood body mass index and development of eating disorder traits across adolescence. | Wiklund CA et al. | β | 2018 | β |
| Diagnostic and genetic overlap of three common mental disorders in structured interviews and health registries. | Torvik FA et al. | β | 2018 | β |
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| Genetic and Environmental Influences on Self-Control: Assessing Self-Control with the ASEBA Self-Control Scale. | Willems YE et al. | β | 2018 | β |
| Genetic influences on conduct disorder. | Salvatore JE et al. | β | 2018 | β |
| Genetics, personality and wellbeing. A twin study of traits, facets and life satisfaction. | RΓΈysamb E et al. | β | 2018 | β |
| Overlap of heritable influences between cannabis use disorder, frequency of use and opportunity to use cannabis: trivariate twin modelling and implications for genetic design. | Hines LA et al. | β | 2018 | β |
| The Speed of Progression to Tobacco and Alcohol Dependence: A Twin Study. | Huggett SB et al. | β | 2018 | β |
| A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents. | Maes HH et al. | β | 2017 | β |
| Alcohol use disorder and divorce: evidence for a genetic correlation in a population-based Swedish sample. | Salvatore JE et al. | β | 2017 | β |
| A Power Calculator for the Classical Twin Design. | Verhulst B | β | 2017 | β |
| Gene-environment interplay in depressive symptoms: moderation by age, sex, and physical illness. | Petkus AJ et al. | β | 2017 | β |
| Genetic and Environmental Contributions to the Association Between Cannabis Use and Psychotic-Like Experiences in Young Adult Twins. | NesvΓ₯g R et al. | β | 2017 | β |
| Genetic and Environmental Pathways Underlying Personality Traits and Perceived Stress: Concurrent and Longitudinal Twin Studies. | Luo J et al. | β | 2017 | β |
| Genetic and Environmental Structure of DSM-IV Criteria for Antisocial Personality Disorder: A Twin Study. | RosenstrΓΆm T et al. | β | 2017 | β |
| Genetic influences on heart rate variability. | Golosheykin S et al. | β | 2017 | β |
| Persistence and innovation effects in genetic and environmental factors in negative emotionality during infancy: A twin study. | Schumann L et al. | β | 2017 | β |
| Stability and change in etiological factors for alcohol use disorder and major depression. | Torvik FA et al. | β | 2017 | β |
| A Bivariate Genetic Analysis of Drug Abuse Ascertained Through Medical and Criminal Registries in Swedish Twins, Siblings and Half-Siblings. | Maes HH et al. | β | 2016 | β |
| Aetiological overlap between obsessive-compulsive related and anxiety disorder symptoms: multivariate twin study. | LΓ³pez-SolΓ C et al. | β | 2016 | β |
| A Longitudinal Twin and Sibling Study of Associations between Insomnia and Depression Symptoms in Young Adults. | Gregory AM et al. | β | 2016 | β |
| Common Etiological Sources of Anxiety, Depression, and Somatic Complaints in Adolescents: A Multiple Rater twin Study. | Ask H et al. | β | 2016 | β |
| Developmental changes in genetic and environmental influences on Chinese child and adolescent anxiety and depression. | Zheng Y et al. | β | 2016 | β |
| Education and alcohol use: A study of gene-environment interaction in young adulthood. | Barr PB et al. | β | 2016 | β |
| Genetic and Environmental Influences on Literacy and Numeracy Performance in Australian School Children in Grades 3, 5, 7, and 9. | Grasby KL et al. | β | 2016 | β |
| Genetic Influences on Hormonal Markers of Chronic HPA Function in Human Hair | Tucker-Drob EM et al. | β | 2016 | β |
| Genetic overlap between impulsivity and alcohol dependence: a large-scale national twin study. | Khemiri L et al. | β | 2016 | β |
| Genetic overlap between type 2 diabetes and depression in Swedish and Danish twin registries. | Kan C et al. | β | 2016 | β |
| Longitudinal Stability and Growth in Literacy and Numeracy in Australian School Students. | Grasby KL et al. | β | 2016 | β |
| Most of the genetic covariation between major depressive and alcohol use disorders is explained by trait measures of negative emotionality and behavioral control. | Ellingson JM et al. | β | 2016 | β |
| Shared Genetic Factors Underlie Migraine and Depression. | Yang Y et al. | β | 2016 | β |
| Childhood ODD and ADHD Behavior: The Effect of Classroom Sharing, Gender, Teacher Gender and Their Interactions. | de Zeeuw EL et al. | β | 2015 | β |
| Genetic and environmental influences on adolescents' smoking involvement: a multi-informant twin study. | Seglem KB et al. | β | 2015 | β |
| Multivariate modeling of body mass index, pulse pressure, systolic and diastolic blood pressure in Chinese twins. | Wu Y et al. | β | 2015 | β |
| Sex differences in the shared genetics of dimensions of self-reported depression and anxiety. | Burton KL et al. | β | 2015 | β |
| Understanding Associations among Family Support, Friend Support, and Psychological Distress. | Horwitz BN et al. | β | 2015 | β |
| A twin-sibling study on the relationship between exercise attitudes and exercise behavior. | Huppertz C et al. | β | 2014 | β |
| Genetic and environmental causes of variation in adolescent anxiety symptoms: a multiple-rater twin study. | Ask H et al. | β | 2014 | β |
| Genetic and environmental contributions to the relationship between internalizing disorders and sick leave granted for mental and somatic disorders. | Torvik FA et al. | β | 2014 | β |
| Personality disorders and long-term sick leave: a population-based study of young adult Norwegian twins. | Gjerde LC et al. | β | 2014 | β |
| Sex differences in genetic and environmental influences on educational attainment and income. | Orstavik RE et al. | β | 2014 | β |
| Shared cognitive impairments and aetiology in ADHD symptoms and reading difficulties. | Cheung CH et al. | β | 2014 | β |
| Strong genetic influences on the stability of autistic traits in childhood. | Holmboe K et al. | β | 2014 | β |
| The dynamic role of genetics on cortical patterning during childhood and adolescence. | Schmitt JE et al. | β | 2014 | β |
| The separation of ADHD inattention and hyperactivity-impulsivity symptoms: pathways from genetic effects to cognitive impairments and symptoms. | Kuntsi J et al. | β | 2014 | β |
| Developmental associations between traits of autism spectrum disorder and attention deficit hyperactivity disorder: a genetically informative, longitudinal twin study. | Taylor MJ et al. | β | 2013 | β |
| Genetic and environmental influences on adult attention deficit hyperactivity disorder symptoms: a large Swedish population-based study of twins. | Larsson H et al. | β | 2013 | β |
| Major depression and life satisfaction: a population-based twin study. | Nes RB et al. | β | 2013 | β |
| A multivariate twin study of autistic traits in 12-year-olds: testing the fractionable autism triad hypothesis. | Robinson EB et al. | β | 2012 | β |
| Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairs. | Larsson H et al. | β | 2012 | β |
| Disentangling the associations between autistic-like and internalizing traits: a community based twin study. | Hallett V et al. | β | 2012 | β |
| Estimation of subject-specific heritabilities from intra-individual variation: iFACE. | Molenaar PC et al. | β | 2012 | β |
| Evidence for Common Etiological Influences on Early Literacy Skills in Kindergarten. | Soden-Hensler B et al. | β | 2012 | β |
| Genetic and environmental causes of variation in trait resilience in young people. | Waaktaar T et al. | β | 2012 | β |
| Genetic and environmental influences underlying externalizing behaviors, cigarette smoking and illicit drug use across adolescence. | Korhonen T et al. | β | 2012 | β |
| Genetic variance of body mass index from childhood to early adulthood. | Dellava JE et al. | β | 2012 | β |
| The etiology of variation in language skills changes with development: a longitudinal twin study of language from 2 to 12 years. | Hayiou-Thomas ME et al. | β | 2012 | β |
| Twin studies as a model for exploring the aetiology of autoimmune thyroid disease. | Brix TH et al. | β | 2012 | β |
| Using genetic information to test causal relationships in cross-sectional data. | Verhulst B et al. | β | 2012 | β |
| A twin study of ADHD symptoms in early adolescence: hyperactivity-impulsivity and inattentiveness show substantial genetic overlap but also genetic specificity. | Greven CU et al. | β | 2011 | β |
| Genetic and environmental contributions to the overlap between psychological, fatigue and somatic symptoms: a twin study in Sri Lanka. | Ball HA et al. | β | 2011 | β |
| Genetic and environmental etiology of disregard for rules. | Petitclerc A et al. | β | 2011 | β |
| Sex differences and developmental stability in genetic and environmental influences on psychoactive substance consumption from early adolescence to young adulthood. | Baker JH et al. | β | 2011 | β |
| A novel approach to genetic and environmental analysis of cross-lagged associations over time: the cross-lagged relationship between self-perceived abilities and school achievement is mediated by genes as well as the environment. | Luo YL et al. | β | 2010 | β |
| Developmental and genetic influences on prefrontal function in adolescents: a longitudinal twin study of WCST performance. | Anokhin AP et al. | β | 2010 | β |
| Genetic covariance structure of the four main features of borderline personality disorder. | Distel MA et al. | β | 2010 | β |
| Limited genetic covariance between autistic traits and intelligence: findings from a longitudinal twin study. | Hoekstra RA et al. | β | 2010 | β |
| Stable genes and changing environments: body mass index across adolescence and young adulthood. | Haberstick BC et al. | β | 2010 | β |
| The genetic association between ADHD symptoms and reading difficulties: the role of inattentiveness and IQ. | Paloyelis Y et al. | β | 2010 | β |
| Heritability of risk-taking in adolescence: a longitudinal twin study. | Anokhin AP et al. | β | 2009 | β |
| More than just IQ: school achievement is predicted by self-perceived abilities--but for genetic rather than environmental reasons. | Greven CU et al. | β | 2009 | β |
| A developmental twin study of symptoms of anxiety and depression: evidence for genetic innovation and attenuation. | Kendler KS et al. | β | 2008 | β |
| Data and theory point to mainly additive genetic variance for complex traits. | Hill WG et al. | β | 2008 | β |
| Dimensional representations of DSM-IV cluster B personality disorders in a population-based sample of Norwegian twins: a multivariate study. | Torgersen S et al. | β | 2008 | β |
| Do the same genetic and environmental effects underlie the covariation of alcohol dependence, smoking, and aggressive behaviour? | von der Pahlen B et al. | β | 2008 | β |
| Evidence for shared genetic influences on self-reported ADHD and autistic symptoms in young adult Australian twins. | Reiersen AM et al. | β | 2008 | β |
| Genetic and environmental contributions to retrospectively reported DSM-IV childhood attention deficit hyperactivity disorder. | Haberstick BC et al. | β | 2008 | β |
| Heritability of frontal brain function related to action monitoring. | Anokhin AP et al. | β | 2008 | β |
| Heterogeneity in antisocial behaviours and comorbidity with depressed mood: a behavioural genetic approach. | Rowe R et al. | β | 2008 | β |
| The development of fears from early adolesence to young adulthood: a multivariate study. | Kendler KS et al. | β | 2008 | β |
| Exploring the inter-relationship of smoking age-at-onset, cigarette consumption and smoking persistence: genes or environment? | Morley KI et al. | β | 2007 | β |
| Genetic support for the dual nature of attention deficit hyperactivity disorder: substantial genetic overlap between the inattentive and hyperactive-impulsive components. | McLoughlin G et al. | β | 2007 | β |
| How Parents Influence School Grades: Hints from a Sample of Adoptive and Biological Families. | Johnson W et al. | β | 2007 | β |
| The relationship between depressive personality disorder and major depressive disorder: a population-based twin study. | Γrstavik RE et al. | β | 2007 | β |