Gene-environment interaction in vulnerability to schizophrenia: findings from the Finnish Adoptive Family Study of Schizophrenia.
paper
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- Authors
- Wahlberg, K E; Wynne, L C; Oja, H; Keskitalo, P; Pykäläinen, L; Lahti, I; Moring, J; Naarala, M; Sorri, A; Seitamaa, M; Läksy, K; Kolassa, J; Tienari, P
- Year
- 1997
- Journal
- The American journal of psychiatry
- PMID
- 9054783
- DOI
- 10.1176/ajp.154.3.355
OBJECTIVE: This study assessed the interaction of genetic risk and rearing-family risk as a subsyndromal test measure of schizophrenic thought disorder in adoptees. METHOD: A group of 58 adoptees with schizophrenic biological mothers was compared with 96 comparison adoptees at ordinary genetic risk; putative adoptee vulnerability was assessed blindly and reliably by using the Rorschach Index of Primitive Thought. Environmental risk was measured by using frequency of communication deviance as a continuous variable, scored independently from Rorschach assessments of the adoptive parents. RESULTS: High genetic risk in itself was not associated with greater vulnerability to schizophrenic thought disorder in the adoptees, as indicated by the Index of Primitive Thought. Also, greater communication deviance in the adoptive parents was not associated with greater thought disorder in the comparison adoptees. However, there was a highly significant gene-environment interaction. Among the offspring of the adoptive parents with high levels of communication deviance, a higher proportion of high-risk than comparison adoptees showed evidence of thought disorder. In contrast, among the offspring of adoptive parents with low communication deviance, a lower proportion of high-risk than comparison adoptees showed evidence of thought disorder. The distribution of communication deviance scores did not differ significantly between the adoptive parents of high-risk offspring and the adoptive parents of comparison offspring. CONCLUSIONS: The findings are consistent with genetic control of sensitivity to the environment. There is no evidence that high genetic risk of schizophrenia among offspring is associated with high levels of communication problems in rearing parents.
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| Title | Year | PMID |
|---|---|---|
| Gene-environment interaction in psychological traits and disorders. | 2011 | 21219196 |
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
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| Sex-related differences in parental rearing patterns in young adults with bipolar disorder. | Zhao H et al. | — | 2023 | → |
| Dysfunctional family functioning in high socioeconomic status families as a risk factor for the development of psychiatric disorders in adoptees: the Finnish Adoptive Family Study of Schizophrenia. | Myllyaho T et al. | — | 2022 | → |
| Parenting in the Context of the Child: Genetic and Social Processes. | Reiss D et al. | — | 2022 | → |
| Traumatic experiences in childhood and adolescence: a meta-analysis of prospective studies assessing risk for psychosis. | Pastore A et al. | — | 2022 | → |
| Using an adoption design to test genetically based differences in risk for child behavior problems in response to home environmental influences. | Cree RA et al. | — | 2021 | → |
| An attachment perspective on the risk for psychosis: Clinical correlates and the predictive value of attachment patterns and mentalization. | Boldrini T et al. | — | 2020 | → |
| Evidence for interaction between genetic liability and childhood trauma in the development of psychotic symptoms. | Pinckaers FME et al. | — | 2019 | → |
| Interaction of genetic vulnerability to schizophrenia and family functioning in adopted-away offspring of mothers with schizophrenia. | Myllyaho T et al. | — | 2019 | → |
| Polygenic Risk Score for Schizophrenia and Face-Processing Network in Young Adulthood. | Lieslehto J et al. | — | 2019 | → |
| Exploring the moderating effects of dopaminergic polymorphisms and childhood adversity on brain morphology in schizophrenia-spectrum disorders. | Hoffmann C et al. | — | 2018 | → |
| Formal thought disorders: from phenomenology to neurobiology. | Kircher T et al. | — | 2018 | → |
| A Set-Based Mixed Effect Model for Gene-Environment Interaction and Its Application to Neuroimaging Phenotypes. | Wang C et al. | — | 2017 | → |
| Relation between psychotic symptoms, parental care and childhood trauma in severe mental disorders. | Catalan A et al. | — | 2017 | → |
| Rethinking Thought Disorder. | Hart M et al. | — | 2017 | → |
| Thought Disorder in Schizophrenia and Bipolar Disorder Probands, Their Relatives, and Nonpsychiatric Controls. | Morgan CJ et al. | — | 2017 | → |
| Commentary: Surveying normal science for children's mental health--expanding reconnaissance to strong inference, trans-syndromal risk and social transactions. A response to Rutter & Pickles (2016). | Reiss D | — | 2016 | → |
| Inner Speech and Clarity of Self-Concept in Thought Disorder and Auditory-Verbal Hallucinations. | de Sousa P et al. | — | 2016 | → |
| A mentalization-based approach to the development of the therapeutic alliance in the treatment of schizophrenia. | Brent BK | — | 2015 | → |
| Association of adoptive child's thought disorders and schizophrenia spectrum disorders with their genetic liability for schizophrenia spectrum disorders, season of birth and parental Communication Deviance. | Roisko R et al. | — | 2015 | → |
| 'No man is an island'. Testing the specific role of social isolation in formal thought disorder. | de Sousa P et al. | — | 2015 | → |
| Wellbeing and resilience: mechanisms of transmission of health and risk in parents with complex mental health problems and their offspring--The WARM Study. | Harder S et al. | — | 2015 | → |
| A randomized trial of family focused therapy with populations at clinical high risk for psychosis: effects on interactional behavior. | O'Brien MP et al. | — | 2014 | → |
| Association of parental communication deviance with offspring's psychiatric and thought disorders. A systematic review and meta-analysis. | Roisko R et al. | — | 2014 | → |
| From adversity to psychosis: pathways and mechanisms from specific adversities to specific symptoms. | Bentall RP et al. | — | 2014 | → |
| Parental communication and psychosis: a meta-analysis. | de Sousa P et al. | — | 2014 | → |
| Development of liability syndromes for schizophrenia: where did they come from and where are they going? | Stone WS et al. | — | 2013 | → |
| Introspection and schizophrenia: a comparative investigation of anomalous self experiences. | Sass L et al. | — | 2013 | → |
| Major depression: a role for hippocampal neurogenesis? | Lee MM et al. | — | 2013 | → |
| Stability in MMPI among adoptees with high and low genetic risk for schizophrenia and with low Communication Deviance of their adoptive parents. | Siira V et al. | — | 2013 | → |
| Clinical applications of schizophrenia genetics: genetic diagnosis, risk, and counseling in the molecular era. | Costain G et al. | — | 2012 | → |
| Early trauma and familial risk in the development of the extended psychosis phenotype in adolescence. | Wigman JT et al. | — | 2012 | → |
| Communication Deviance in parents of families with adoptees at a high or low risk of schizophrenia-spectrum disorders and its associations with attributes of the adoptee and the adoptive parents. | Roisko R et al. | — | 2011 | → |
| Gene-environment interaction in psychological traits and disorders. | Dick DM | — | 2011 | → |
| Schizophrenia in the offspring of antenatally depressed mothers in the northern Finland 1966 birth cohort: relationship to family history of psychosis. | Mäki P et al. | — | 2010 | → |
| The role of genetics in the etiology of schizophrenia. | Gejman PV et al. | — | 2010 | → |
| Epigenetic mediation of environmental influences in major psychotic disorders. | Rutten BP et al. | — | 2009 | → |
| From a genetic predisposition to an interactive predisposition: rethinking the ethical implications of screening for gene-environment interactions. | Tabery J | — | 2009 | → |
| Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia. | Rastogi A et al. | — | 2009 | → |
| Schizophrenia: genetics, prevention and rehabilitation. | Olgiati P et al. | — | 2009 | → |
| The centrality of personal relationships in the creation and amelioration of mental health problems: the current interdisciplinary case. | Pilgrim D et al. | — | 2009 | → |
| Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. | van Os J et al. | — | 2008 | → |
| MMPI measures as signs of predisposition to mental disorder among adoptees at high risk for schizophrenia. | Siira V et al. | — | 2008 | → |
| Rural environments reduce the genetic influence on adolescent substance use and rule-breaking behavior. | Legrand LN et al. | — | 2008 | → |
| Social predictors of psychotic experiences: specificity and psychological mechanisms. | Bentall RP et al. | — | 2008 | → |
| A cross-sectional study to investigate current social adjustment of offspring of patients with schizophrenia. | Terzian AC et al. | — | 2007 | → |
| Association study of putative promoter polymorphisms in the neuroplastin gene and schizophrenia. | Saito A et al. | — | 2007 | → |
| Interaction of genetic vulnerability to schizophrenia and Communication Deviance of adoptive parents associated with MMPI schizophrenia vulnerability indicators of adoptees. | Siira V et al. | — | 2007 | → |
| Lyman C. Wynne and transformation of the field of family-and-schizophrenia. | Sluzki CE | — | 2007 | → |
| Prospects for a cognitive-developmental account of psychotic experiences. | Bentall RP et al. | — | 2007 | → |
| The contribution of gene-environment interaction to psychopathology. | Thapar A et al. | — | 2007 | → |
| The primacy of psychoanalytic intervention in recovery from the psychoses and schizophrenias. | Gibbs PL | — | 2007 | → |
| A public health genetic approach for schizophrenia. | Danese A | — | 2006 | → |
| I. Genotype-environment interaction in the schizophrenia spectrum: genetic liability and global family ratings in the Finnish Adoption Study. | Wynne LC et al. | — | 2006 | → |
| II. Genotype-environment interaction in the schizophrenia spectrum: qualitative observations. | Wynne LC et al. | — | 2006 | → |
| Madness explained: why we must reject the Kraepelinian paradigm and replace it with a 'complaint-orientated' approach to understanding mental illness. | Bentall R | — | 2006 | → |
| Measured Gene-Environment Interactions in Psychopathology: Concepts, Research Strategies, and Implications for Research, Intervention, and Public Understanding of Genetics. | Moffitt TE et al. | — | 2006 | → |
| Prenatal and postnatal maternal contributions in the infection model of schizophrenia. | Meyer U et al. | — | 2006 | → |
| Suicide attempts and severe psychiatric morbidity among former child welfare clients--a national cohort study. | Vinnerljung B et al. | — | 2006 | → |
| The International Society for Developmental Psychobiology annual meeting symposium: Impact of early life experiences on brain and behavioral development. | Sullivan R et al. | — | 2006 | → |
| Are apparent associations between parental representations and psychosis risk mediated by early trauma? | Janssen I et al. | — | 2005 | → |
| Commentary: Gene-environment interplay in the context of genetics, epigenetics, and gene expression. | Kramer DA | — | 2005 | → |
| Migration, family dysfunction and psychotic symptoms in children and adolescents. | Patino LR et al. | — | 2005 | → |
| Observing relationships in Finnish adoptive families: Oulu Family Rating Scale. | Tienari P et al. | — | 2005 | → |
| Predictors of schizophrenia: evidence from the Northern Finland 1966 Birth Cohort and other sources. | Isohanni M et al. | — | 2005 | → |
| Premorbid indicators and risk for schizophrenia: a selective review and update. | Keshavan MS et al. | — | 2005 | → |
| Risk for schizophrenia--broadening the concepts, pushing back the boundaries. | Cannon M et al. | — | 2005 | → |
| Developmental precursors of psychosis. | Isohanni M et al. | — | 2004 | → |
| Early presence of thought disorder as a prospective sign of mental disorder. | Metsänen M et al. | — | 2004 | → |
| Gene-environment interactions in mental disorders. | Tsuang MT et al. | — | 2004 | → |
| Genotype-environment interaction in schizophrenia-spectrum disorder. Long-term follow-up study of Finnish adoptees. | Tienari P et al. | — | 2004 | → |
| Links between creativity and mental disorder. | Lauronen E et al. | — | 2004 | → |
| Schizophrenia-an evolutionary enigma? | Brüne M | — | 2004 | → |
| Schizophrenia: etiology and course. | Walker E et al. | — | 2004 | → |
| Schizophrenia in the offspring of antenatally depressed mothers: a 31-year follow-up of the Northern Finland 1966 Birth Cohort. | Mäki P et al. | — | 2004 | → |
| Trajectories of psychosis: towards a new social biology of schizophrenia. | Harrison G | — | 2004 | → |
| Childhood developmental abnormalities in schizophrenia: evidence from high-risk studies. | Niemi LT et al. | — | 2003 | → |
| Genotype-environment interaction in children's adjustment to parental separation. | O'Connor TG et al. | — | 2003 | → |
| Maternal separation at birth and schizophrenia--a long-term follow-up of the Finnish Christmas Seal Home Children. | Mäki P et al. | — | 2003 | → |
| Stability of formal thought disorder and referential communication disturbances in schizophrenia. | Docherty NM et al. | — | 2003 | → |
| Annotation: The 'effects' of parenting reconsidered: findings, challenges, and applications. | O'Connor TG | — | 2002 | → |
| Could stress cause psychosis in individuals vulnerable to schizophrenia? | Corcoran C et al. | — | 2002 | → |
| Molecular genetic studies of schizophrenia: challenges and insights. | Kato C et al. | — | 2002 | → |
| Genes, environment and schizophrenia. | Tsuang MT et al. | — | 2001 | → |
| Insight into mental illness and child maltreatment risk among mothers with major psychiatric disorders. | Mullick M et al. | — | 2001 | → |
| Long-term stability of communication deviance. | Wahlberg KE et al. | — | 2001 | → |
| Nature, nurture and mental disorder: old concepts in the new millennium. | Cooper B | — | 2001 | → |
| Testing hypotheses on specific environmental causal effects on behavior. | Rutter M et al. | — | 2001 | → |
| The Rorschach: facts, fictions, and future. | Viglione DJ et al. | — | 2001 | → |
| Adoption studies of schizophrenia. | Ingraham LJ et al. | — | 2000 | → |
| Implications of genetic epidemiology for the prevention of substance use disorders. | Merikangas KR et al. | — | 2000 | → |
| Neurobehavioral deficits in offspring of schizophrenic parents: liability indicators and predictors of illness. | Erlenmeyer-Kimling L | — | 2000 | → |
| Schizophrenia: genes and environment. | Tsuang M | — | 2000 | → |
| Schizophrenia: vulnerability versus disease. | Tsuang MT et al. | — | 2000 | → |
| The epidemiology of the genetic liability for schizophrenia. | Hallmayer J | — | 2000 | → |
| Can excellent school performance be a precursor of schizophrenia? A 28-year follow-up in the Northern Finland 1966 birth cohort. | Isohanni I et al. | — | 1999 | → |
| Genotype-environment interactions and schizophrenia. | Tienari P | — | 1999 | → |
| Sensorimotor and cognitive development of infants of mothers with schizophrenia. | Yoshida K et al. | — | 1999 | → |
| Communication disturbances and family psychiatric history in parents of schizophrenic patients. | Docherty NM et al. | — | 1998 | → |
| Genetics of autism: overview and new directions. | Szatmari P et al. | — | 1998 | → |
| Sex differences in self-reported schizotypal traits in relatives of schizophrenic probands. | Kremen WS et al. | — | 1998 | → |
| The ecogenetics of schizophrenia: a review. | van Os J et al. | — | 1998 | → |
| No cytogenetical abnormalities in a set of schizophrenic quadruplets. | Jönsson EG et al. | — | 1997 | → |