Why most discovered true associations are inflated.
paper
Cited
Public
Unavailable
- Authors
- Ioannidis, John P A
- Year
- 2008
- Journal
- Epidemiology (Cambridge, Mass.)
- PMID
- 18633328
- DOI
- 10.1097/EDE.0b013e31818131e7
Newly discovered true (non-null) associations often have inflated effects compared with the true effect sizes. I discuss here the main reasons for this inflation. First, theoretical considerations prove that when true discovery is claimed based on crossing a threshold of statistical significance and the discovery study is underpowered, the observed effects are expected to be inflated. This has been demonstrated in various fields ranging from early stopped clinical trials to genome-wide associations. Second, flexible analyses coupled with selective reporting may inflate the published discovered effects. The vibration ratio (the ratio of the largest vs. smallest effect on the same association approached with different analytic choices) can be very large. Third, effects may be inflated at the stage of interpretation due to diverse conflicts of interest. Discovered effects are not always inflated, and under some circumstances may be deflated-for example, in the setting of late discovery of associations in sequentially accumulated overpowered evidence, in some types of misclassification from measurement error, and in conflicts causing reverse biases. Finally, I discuss potential approaches to this problem. These include being cautious about newly discovered effect sizes, considering some rational down-adjustment, using analytical methods that correct for the anticipated inflation, ignoring the magnitude of the effect (if not necessary), conducting large studies in the discovery phase, using strict protocols for analyses, pursuing complete and transparent reporting of all results, placing emphasis on replication, and being fair with interpretation of results.
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| Overestimation of benefit when clinical trials stop early: a simulation study. | Liu S et al. | — | 2022 | → |
| Polygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype? | Fusar-Poli L et al. | — | 2022 | → |
| Psychosocial Intervention in Chronic Obstructive Pulmonary Disease: Meta-Analysis of Randomized Controlled Trials. | Farver-Vestergaard I et al. | — | 2022 | → |
| Published correlational effect sizes in social and developmental psychology. | Weinerová J et al. | — | 2022 | → |
| Replicability, Robustness, and Reproducibility in Psychological Science. | Nosek BA et al. | — | 2022 | → |
| Reproducibility in the absence of selective reporting: An illustration from large-scale brain asymmetry research. | Kong XZ et al. | — | 2022 | → |
| Risk Factors for Ovarian Cancer: An Umbrella Review of the Literature. | Whelan E et al. | — | 2022 | → |
| Risk of Dementia in Cancer Survivors: A Meta-Analysis of Population-Based Cohort Studies. | Zhang DD et al. | — | 2022 | → |
| rTMS Reduces Craving and Alcohol Use in Patients with Alcohol Use Disorder: Results of a Randomized, Sham-Controlled Clinical Trial. | Belgers M et al. | — | 2022 | → |
| Sex is a defining feature of neuroimaging phenotypes in major brain disorders. | Salminen LE et al. | — | 2022 | → |
| Speech-in-noise perception in musicians and non-musicians: A multi-level meta-analysis. | Hennessy S et al. | — | 2022 | → |
| Statistical Power and Swallowing Rehabilitation Research: Current Landscape and Next Steps. | Borders JC et al. | — | 2022 | → |
| Stress history affects heat tolerance in an aquatic ectotherm (Chinook salmon, Oncorhynchus tshawytscha). | Rodgers EM et al. | — | 2022 | → |
| Teaching geriatric medicine through gamification: a tool for enhancing postgraduate education in geriatric medicine. | Schlögl M et al. | — | 2022 | → |
| The hare and the tortoise: physical activity intensity and scientific translation. | Matthews CE et al. | — | 2022 | → |
| The physiological study of emotional piloerection: A systematic review and guide for future research. | McPhetres J et al. | — | 2022 | → |
| The role of diet in renal cell carcinoma incidence: an umbrella review of meta-analyses of observational studies. | Liao Z et al. | — | 2022 | → |
| The role of task demands in racial face encoding. | Yang B et al. | — | 2022 | → |
| Vibration of effect in more than 16 000 pooled analyses of individual participant data from 12 randomised controlled trials comparing canagliflozin and placebo for type 2 diabetes mellitus: multiverse analysis. | Gouraud H et al. | — | 2022 | → |
| What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. | Ching CRK et al. | — | 2022 | → |
| A Biased Perspective on Brain Imaging of ADHD. | Castellanos FX | — | 2021 | → |
| Aerobic scope and climate warming: Testing the "plastic floors and concrete ceilings" hypothesis in the estuarine crocodile (Crocodylus porosus). | Rodgers EM et al. | — | 2021 | → |
| Age of First Exposure to Contact and Collision Sports and Later in Life Brain Health: A Narrative Review. | Iverson GL et al. | — | 2021 | → |
| An umbrella review of the evidence associating diet and cancer risk at 11 anatomical sites. | Papadimitriou N et al. | — | 2021 | → |
| Applications of Machine Learning in Human Microbiome Studies: A Review on Feature Selection, Biomarker Identification, Disease Prediction and Treatment. | Marcos-Zambrano LJ et al. | — | 2021 | → |
| Assessment of early exaggerated treatment effects in orthodontic interventions using cumulative meta-analysis. | Seehra J et al. | — | 2021 | → |
| Binding Potassium to Improve Treatment With Renin-Angiotensin-Aldosterone System Inhibitors: Results From Multiple One-Stage Pairwise and Network Meta-Analyses of Clinical Trials. | Lizaraso-Soto F et al. | — | 2021 | → |
| Blending group-based psychoeducation with a smartphone intervention for the reduction of depressive symptoms: results of a randomized controlled pilot study. | Lukas CA et al. | — | 2021 | → |
| Brain-wide inferiority and equivalence tests in fMRI group analyses: Selected applications. | Gerchen MF et al. | — | 2021 | → |
| Concerns About the Special Article on Hydroxychloroquine and Azithromycin in High-Risk Outpatients With COVID-19. | Fox MP et al. | — | 2021 | → |
| Does Neonatal Imitation Exist? Insights From a Meta-Analysis of 336 Effect Sizes. | Davis J et al. | — | 2021 | → |
| Do Newborns Have the Ability to Imitate? | Slaughter V | — | 2021 | → |
| Effect size, sample size and power of forced swim test assays in mice: Guidelines for investigators to optimize reproducibility. | Smalheiser NR et al. | — | 2021 | → |
| Estimates of the mean difference in orthopaedic randomized trials: obligatory yet obscure. | Raittio L et al. | — | 2021 | → |
| Examining the robustness of observational associations to model, measurement and sampling uncertainty with the vibration of effects framework. | Klau S et al. | — | 2021 | → |
| External validation of automated focal cortical dysplasia detection using morphometric analysis. | David B et al. | — | 2021 | → |
| Extracurricular Activities, Screen Media Activity, and Sleep May Be Modifiable Factors Related to Children's Cognitive Functioning: Evidence From the ABCD Study<sup>®</sup>. | Kirlic N et al. | — | 2021 | → |
| Functional co-activation of the default mode network in APOE ε4-carriers: A replication study. | Mentink LJ et al. | — | 2021 | → |
| Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group. | Rossetti MG et al. | — | 2021 | → |
| Gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators. | Tierney BT et al. | — | 2021 | → |
| Genetic Influences on Patient-Oriented Outcomes in Traumatic Brain Injury: A Living Systematic Review of Non-Apolipoprotein E Single-Nucleotide Polymorphisms. | Zeiler FA et al. | — | 2021 | → |
| Gestational weight gain influences, beliefs, and goals among Marshallese pregnant women in Arkansas: a mixed-methods analysis. | Ayers BL et al. | — | 2021 | → |
| Increasing the statistical power of animal experiments with historical control data. | Bonapersona V et al. | — | 2021 | → |
| Making ERP research more transparent: Guidelines for preregistration. | Paul M et al. | — | 2021 | → |
| Meaningful associations in the adolescent brain cognitive development study. | Dick AS et al. | — | 2021 | → |
| Neglect of publication bias compromises meta-analyses of educational research. | Ropovik I et al. | — | 2021 | → |
| Neurocan genome-wide psychiatric risk variant affects explicit memory performance and hippocampal function in healthy humans. | Assmann A et al. | — | 2021 | → |
| Neuroimaging in attention-deficit/hyperactivity disorder. | Pereira-Sanchez V et al. | — | 2021 | → |
| Next Steps in Pneumonia Severity Scores. | Vazquez Guillamet MC et al. | — | 2021 | → |
| One-year dietary supplementation with walnuts modifies exosomal miRNA in elderly subjects. | López de Las Hazas MC et al. | — | 2021 | → |
| Power contours: Optimising sample size and precision in experimental psychology and human neuroscience. | Baker DH et al. | — | 2021 | → |
| Predicting evolutionary change at the DNA level in a natural Mimulus population. | Monnahan PJ et al. | — | 2021 | → |
| Predicting replicability-Analysis of survey and prediction market data from large-scale forecasting projects. | Gordon M et al. | — | 2021 | → |
| Pre-eclampsia and long-term health outcomes for mother and infant: an umbrella review. | Pittara T et al. | — | 2021 | → |
| Preregistration and Registered Reports: A Key Pathway to Enhancing Robustness and Replicability in Mental Health Research. | Barch DM | — | 2021 | → |
| Putting Psychology to the Test: Rethinking Model Evaluation Through Benchmarking and Prediction. | Rocca R et al. | — | 2021 | → |
| Racial preferences in sexual attraction among White heterosexual and gay men: Evidence from sexual arousal patterns and negative racial attitudes. | Hsu KJ et al. | — | 2021 | → |
| Systematic Review: Medication Effects on Brain Intrinsic Functional Connectivity in Patients With Attention-Deficit/Hyperactivity Disorder. | Pereira-Sanchez V et al. | — | 2021 | → |
| Teaching Hardy-Weinberg Equilibrium using Population-Level Punnett Squares: Facilitating Calculation for Students with Math Anxiety. | Williams KR et al. | — | 2021 | → |
| The case for preregistering all region of interest (ROI) analyses in neuroimaging research. | Gentili C et al. | — | 2021 | → |
| The exposome in practice: an exploratory panel study of biomarkers of air pollutant exposure in Chinese people aged 60-69 years (China BAPE Study). | Tang S et al. | — | 2021 | → |
| The methodological quality of 176,620 randomized controlled trials published between 1966 and 2018 reveals a positive trend but also an urgent need for improvement. | Vinkers CH et al. | — | 2021 | → |
| The multiplicity of analysis strategies jeopardizes replicability: lessons learned across disciplines. | Hoffmann S et al. | — | 2021 | → |
| The promise and deceit of genomic selection component analyses. | Kelly JK | — | 2021 | → |
| The Rollercoaster of Paclitaxel in the Lower Limbs and Skeletons in the Closet: An Opinion Review. | Katsanos K et al. | — | 2021 | → |
| The sexual health, orientation, and activity of autistic adolescents and adults. | Weir E et al. | — | 2021 | → |
| The statistical properties of RCTs and a proposal for shrinkage. | van Zwet E et al. | — | 2021 | → |
| Tick-Tock Consider the Clock: The Influence of Circadian and External Cycles on Time of Day Variation in the Human Metabolome-A Review. | Hancox TPM et al. | — | 2021 | → |
| Utilizing a Biology-Driven Approach to Map the Exposome in Health and Disease: An Essential Investment to Drive the Next Generation of Environmental Discovery. | Chung MK et al. | — | 2021 | → |
| Visualizing the evolution of evidence: Cumulative network meta-analyses of new generation antidepressants in the last 40 years. | Luo Y et al. | — | 2021 | → |
| What is the optimum design for my animal experiment? | Karp NA et al. | — | 2021 | → |
| Analyzing cellular immunogenicity in vaccine clinical trials: a new statistical method including non-specific responses for accurate estimation of vaccine effect. | Lhomme E et al. | — | 2020 | → |
| An Examination of Effect Sizes and Statistical Power in Speech, Language, and Hearing Research. | Gaeta L et al. | — | 2020 | → |
| Association between cardiorespiratory fitness and colorectal cancer in the UK Biobank. | Hillreiner A et al. | — | 2020 | → |
| Associations between gastro-oesophageal reflux disease and a range of diseases: an umbrella review of systematic reviews and meta-analyses. | Tan J et al. | — | 2020 | → |
| Behavioral and brain signatures of substance use vulnerability in childhood. | Rapuano KM et al. | — | 2020 | → |
| Behavioural responses of anxiety in aversive and non-aversive conditions between young and aged Sprague-Dawley rats. | Hiew LF et al. | — | 2020 | → |
| Bilingualism Is Associated with a Delayed Onset of Dementia but Not with a Lower Risk of Developing it: a Systematic Review with Meta-Analyses. | Brini S et al. | — | 2020 | → |
| Biological Evidence in Adult and Adolescent Sexual Assault Cases: Timing and Relationship to Arrest. | Cross TP et al. | — | 2020 | → |
| Characterization of genetic and phenotypic heterogeneity of obstructive sleep apnea using electronic health records. | Veatch OJ et al. | — | 2020 | → |
| Clinical Interventions and All-Cause Mortality of Patients with Chronic Kidney Disease: An Umbrella Systematic Review of Meta-Analyses. | Kim JY et al. | — | 2020 | → |
| Clinical Trial Evidence Supporting US Food and Drug Administration Approval of Novel Cancer Therapies Between 2000 and 2016. | Ladanie A et al. | — | 2020 | → |
| Cluster failure or power failure? Evaluating sensitivity in cluster-level inference. | Noble S et al. | — | 2020 | → |
| Comparing meta-analyses and preregistered multiple-laboratory replication projects. | Kvarven A et al. | — | 2020 | → |
| Consideration of confounding was suboptimal in the reporting of observational studies in psychiatry: a meta-epidemiological study. | Munkholm K et al. | — | 2020 | → |
| Does learning history shape the associability of outcomes? Further tests of the outcome predictability effect. | Liu W et al. | — | 2020 | → |
| Effect of Weight Loss Medications on Hepatic Steatosis and Steatohepatitis: A Systematic Review. | Pan CS et al. | — | 2020 | → |
| emagnification: A tool for estimating effect-size magnification and performing design calculations in epidemiological studies. | Miller DJ et al. | — | 2020 | → |
| ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing. | Schmaal L et al. | — | 2020 | → |
| Ensuring the quality and specificity of preregistrations. | Bakker M et al. | — | 2020 | → |
| Evaluating the resource allocation index as a potential fMRI-based biomarker for substance use disorder. | Moradi M et al. | — | 2020 | → |
| Gene expression variability in human and chimpanzee populations share common determinants | Fair BJ et al. | — | 2020 | — |
| Gene expression variability in human and chimpanzee populations share common determinants. | Fair BJ et al. | — | 2020 | → |
| Genetic model of MS severity predicts future accumulation of disability. | Jackson KC et al. | — | 2020 | → |
| How to Remember Something You Didn't Say. | Schreckenbach F et al. | — | 2020 | → |
| Importance of Systematic Reviews and Meta-analyses of Animal Studies: Challenges for Animal-to-Human Translation. | Bahadoran Z et al. | — | 2020 | → |
| Improving natural product research translation: From source to clinical trial. | Sorkin BC et al. | — | 2020 | → |
| Intranasal oxytocin modulates brain responses to voice-identity recognition in typically developing individuals, but not in ASD. | Borowiak K et al. | — | 2020 | → |
| Machine Learning Analysis of Electronic Nose in a Transdiagnostic Community Sample With a Streamlined Data Collection Approach: No Links Between Volatile Organic Compounds and Psychiatric Symptoms. | Xu B et al. | — | 2020 | → |
| Methylation of OXT and OXTR genes, central oxytocin, and social behavior in female macaques. | De Leon D et al. | — | 2020 | → |
| Most oxytocin administration studies are statistically underpowered to reliably detect (or reject) a wide range of effect sizes. | Quintana DS | — | 2020 | → |
| Moving Sport and Exercise Science Forward: A Call for the Adoption of More Transparent Research Practices. | Caldwell AR et al. | — | 2020 | → |
| MRI-based biomarkers of accelerated aging and dementia risk in midlife: how close are we? | Elliott ML | — | 2020 | → |
| Organizational Downsizing, Work Conditions, and Employee Outcomes: Identifying Targets for Workplace Intervention among Survivors. | Frone MR et al. | — | 2020 | → |
| Performance of Gene Expression Profile Tests for Prognosis in Patients With Localized Cutaneous Melanoma: A Systematic Review and Meta-analysis. | Marchetti MA et al. | — | 2020 | → |
| Power, precision, and sample size estimation in sport and exercise science research. | Abt G et al. | — | 2020 | → |
| Predicting mid-life capital formation with pre-school delay of gratification and life-course measures of self-regulation. | Benjamin DJ et al. | — | 2020 | → |
| Predicting tibia shaft nonunions at initial fixation: An external validation of the Nonunion Risk Determination (NURD) score in the SPRINT trial data. | O'Hara NN et al. | — | 2020 | → |
| Predictive modeling of neurobehavioral state and trait variation across development. | Sanchez-Alonso S et al. | — | 2020 | → |
| Predictors of mathematics in primary school: Magnitude comparison, verbal and spatial working memory measures. | Caviola S et al. | — | 2020 | → |
| Problematic methodology in a systematic review and meta-analysis of DecisionDx-Melanoma. | Marchetti MA et al. | — | 2020 | → |
| P-values - a chronic conundrum. | Gao J | — | 2020 | → |
| Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study. | Nudel R et al. | — | 2020 | → |
| Redefining significance and reproducibility for medical research: A plea for higher P-value thresholds for diagnostic and prognostic models. | Steyerberg EW et al. | — | 2020 | → |
| Sample size evolution in neuroimaging research: An evaluation of highly-cited studies (1990-2012) and of latest practices (2017-2018) in high-impact journals. | Szucs D et al. | — | 2020 | → |
| Soy and Isoflavone Consumption and Multiple Health Outcomes: Umbrella Review of Systematic Reviews and Meta-Analyses of Observational Studies and Randomized Trials in Humans. | Li N et al. | — | 2020 | → |
| Statistical analysis of longitudinal data on tumour growth in mice experiments. | Zavrakidis I et al. | — | 2020 | → |
| The generalizability crisis. | Yarkoni T | — | 2020 | → |
| The Impact of Iron Supplementation for Treating Anemia in Patients with Chronic Kidney Disease: Results from Pairwise and Network Meta-Analyses of Randomized Controlled Trials. | Adler M et al. | — | 2020 | → |
| The Potential of Functional Near-Infrared Spectroscopy-Based Neurofeedback-A Systematic Review and Recommendations for Best Practice. | Kohl SH et al. | — | 2020 | → |
| The Predictive Approaches to Treatment effect Heterogeneity (PATH) Statement. | Kent DM et al. | — | 2020 | → |
| The Predictive Approaches to Treatment effect Heterogeneity (PATH) Statement: Explanation and Elaboration. | Kent DM et al. | — | 2020 | → |
| The "sex gap" in COVID-19 trials: a scoping review. | Schiffer VMMM et al. | — | 2020 | → |
| The term 'Pilot Study' is misused in veterinary medicine: a critical assessment. | Rishniw M et al. | — | 2020 | → |
| TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women. | Azar P et al. | — | 2020 | → |
| Two years into the Brazilian Reproducibility Initiative: reflections on conducting a large-scale replication of Brazilian biomedical science. | Neves K et al. | — | 2020 | → |
| Using collaboration networks to identify authorship dependence in meta-analysis results. | Moulin TC et al. | — | 2020 | → |
| Vibration of effects in epidemiologic studies of alcohol consumption and breast cancer risk. | Chu L et al. | — | 2020 | → |
| Absolute and relative pitch processing in the human brain: neural and behavioral evidence. | Leipold S et al. | — | 2019 | → |
| Accumulation Bias in meta-analysis: the need to consider <i>time</i> in error control. | Ter Schure J et al. | — | 2019 | → |
| A data-sharing agreement helps to increase researchers' willingness to share primary data: results from a randomized controlled trial. | Polanin JR et al. | — | 2019 | → |
| A default prior for regression coefficients. | van Zwet E | — | 2019 | → |
| A preliminary investigation of attachment style and inflammation in African-American young adults. | Ehrlich KB et al. | — | 2019 | → |
| Attentional bias for threat: Crisis or opportunity? | McNally RJ | — | 2019 | → |
| Autistic traits influence the strategic diversity of information sampling: Insights from two-stage decision models. | Lu H et al. | — | 2019 | → |
| Be positive about negatives-recommendations for the publication of negative (or null) results. | Bespalov A et al. | — | 2019 | → |
| Cholesterol-Lowering Treatment in Chronic Kidney Disease: Multistage Pairwise and Network Meta-Analyses. | Herrera-Gómez F et al. | — | 2019 | → |
| Common Inflammation-Related Candidate Gene Variants and Acute Kidney Injury in 2647 Critically Ill Finnish Patients. | Vilander LM et al. | — | 2019 | → |
| Countering the Curse of Dimensionality: Exploring Data-generating Mechanisms Through Participant Observation and Mechanistic Modeling. | Hubbard A et al. | — | 2019 | → |
| DEBATE-statistical analysis plans for observational studies. | Hiemstra B et al. | — | 2019 | → |
| Effect Declines Are Systematic, Strong, and Ubiquitous: A Meta-Meta-Analysis of the Decline Effect in Intelligence Research. | Pietschnig J et al. | — | 2019 | → |
| Effectiveness of psychological treatments for depression and alcohol use disorder delivered by community-based counsellors: two pragmatic randomised controlled trials within primary healthcare in Nepal. | Jordans MJD et al. | — | 2019 | → |
| Effect of Statin on Cancer Incidence: An Umbrella Systematic Review and Meta-Analysis. | Jeong GH et al. | — | 2019 | → |
| Effect Size Guidelines, Sample Size Calculations, and Statistical Power in Gerontology. | Brydges CR | — | 2019 | → |
| Efficacy of glutamine in postinfection IBS. | Ford AC et al. | — | 2019 | → |
| Efficacy of pharmacotherapy for OSA in adults: A systematic review and network meta-analysis. | Gaisl T et al. | — | 2019 | → |
| Emotional oddball: A review on memory effects. | Schlüter H et al. | — | 2019 | → |
| Empirical examination of the replicability of associations between brain structure and psychological variables. | Kharabian Masouleh S et al. | — | 2019 | → |
| Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial. | ELFIN trial investigators group | — | 2019 | → |
| Environmental risk factors and biomarkers for autism spectrum disorder: an umbrella review of the evidence. | Kim JY et al. | — | 2019 | → |
| Evaluation of a meta-analysis of air quality and heart attacks, a case study. | Stanley Young S et al. | — | 2019 | → |
| Exposome-wide association study of semen quality: Systematic discovery of endocrine disrupting chemical biomarkers in fertility require large sample sizes. | Chung MK et al. | — | 2019 | → |
| Fragility Index, power, strength and robustness of findings in sports medicine and arthroscopic surgery: a secondary analysis of data from a study on use of the Fragility Index in sports surgery. | Reito A et al. | — | 2019 | → |
| General functional connectivity: Shared features of resting-state and task fMRI drive reliable and heritable individual differences in functional brain networks. | Elliott ML et al. | — | 2019 | → |
| Genetic association studies: Is non-replication failure or progress? | Gruber PJ | — | 2019 | → |
| Heterogeneity in banker culture and its influence on dishonesty. | Rahwan Z et al. | — | 2019 | → |
| <i>P</i>-curve accurately rejects evidence for homeopathic ultramolecular dilutions. | Reisman S et al. | — | 2019 | → |
| Is Fluoride Potentially Neurotoxic? | Bellinger DC | — | 2019 | → |
| Lack of statistical power as a major limitation in understanding MHC-mediated immunocompetence in wild vertebrate populations. | Gaigher A et al. | — | 2019 | → |
| Marginal structural models and other analyses allow multiple estimates of treatment effects in randomized clinical trials: Meta-epidemiological analysis. | Ewald H et al. | — | 2019 | → |
| Measuring viability selection from prospective cohort mortality studies: A case study in maritime pine. | Robledo-Arnuncio JJ et al. | — | 2019 | → |
| Methodological reporting behavior, sample sizes, and statistical power in studies of event-related potentials: Barriers to reproducibility and replicability. | Clayson PE et al. | — | 2019 | → |
| Moving college health research forward: Reconsidering our reliance on statistical significance testing. | Barry AE et al. | — | 2019 | → |
| Near-Infrared Spectroscopy Monitoring in Cardiac and Noncardiac Surgery: Pairwise and Network Meta-Analyses. | Ortega-Loubon C et al. | — | 2019 | → |
| Pair-bonding, fatherhood, and the role of testosterone: A meta-analytic review. | Grebe NM et al. | — | 2019 | → |
| Potential Diagnostic and Prognostic Biomarkers of Circular RNAs for Lung Cancer in China. | Wang C et al. | — | 2019 | → |
| Practical tools and strategies for researchers to increase replicability. | Nuijten MB | — | 2019 | → |
| Prediction of cardiovascular risk by Lp(a) concentrations or genetic variants within the LPA gene region. | Kronenberg F | — | 2019 | → |
| Publication bias examined in meta-analyses from psychology and medicine: A meta-meta-analysis. | van Aert RCM et al. | — | 2019 | → |
| Quality of methods and reporting in association studies of chronic periodontitis and IL1A -889 and IL1B +3953/4 SNPs: A systematic review. | Citterio F et al. | — | 2019 | → |
| Quantifying evidential value and selective reporting in recent and 10-year past psychophysiological literature: A pre-registered P-curve analysis. | Carbine KA et al. | — | 2019 | → |
| Quantifying the presence of evidential value and selective reporting in food-related inhibitory control training: a <i>p</i>-curve analysis. | Carbine KA et al. | — | 2019 | → |
| Ratio Format Shapes Health Decisions: The Practical Significance of the "1-in-X" Effect. | Sirota M et al. | — | 2019 | → |
| Recognising the heterogeneity of autism. | Lord C | — | 2019 | → |
| Recognition of facial expression and identity in part reflects a common ability, independent of general intelligence and visual short-term memory. | Connolly HL et al. | — | 2019 | → |
| Resting States and Memory Consolidation: A Preregistered Replication and Meta-Analysis. | Humiston GB et al. | — | 2019 | → |
| Risk factors for endometrial cancer: An umbrella review of the literature. | Raglan O et al. | — | 2019 | → |
| Scientific Utopia III: Crowdsourcing Science. | Uhlmann EL et al. | — | 2019 | → |
| Single pivotal trials with few corroborating characteristics were used for FDA approval of cancer therapies. | Ladanie A et al. | — | 2019 | → |
| Smartphone-based emotion recognition skills training for alexithymia - A randomized controlled pilot study. | Lukas CA et al. | — | 2019 | → |
| Statistical power estimation in non-invasive brain stimulation studies and its clinical implications: An exploratory study of the meta-analyses. | Mitra S et al. | — | 2019 | → |
| Tea Consumption and Health Outcomes: Umbrella Review of Meta-Analyses of Observational Studies in Humans. | Yi M et al. | — | 2019 | → |
| Temporal Instability of Evidence Base: A Threat to Policy Making? | Koricheva J et al. | — | 2019 | → |
| Testosterone, cortisol, and status-striving personality features: A review and empirical evaluation of the Dual Hormone hypothesis. | Grebe NM et al. | — | 2019 | → |
| The design and development of MyT1DHero: A mobile app for adolescents with type 1 diabetes and their parents. | Holtz BE et al. | — | 2019 | → |
| Theory of mind and psychosocial characteristics in older men. | Radecki MA et al. | — | 2019 | → |
| The relevance of alpha phase in human perception. | Ruzzoli M et al. | — | 2019 | → |
| Transdiagnostic Risk Calculator for the Automatic Detection of Individuals at Risk and the Prediction of Psychosis: Second Replication in an Independent National Health Service Trust. | Fusar-Poli P et al. | — | 2019 | → |
| Vibration of effects from diverse inclusion/exclusion criteria and analytical choices: 9216 different ways to perform an indirect comparison meta-analysis. | Palpacuer C et al. | — | 2019 | → |
| Visual Perceptual Load Does Not Affect the Frequency Mismatch Negativity. | Wiens S et al. | — | 2019 | → |
| Women using hormonal contraceptives show increased valence ratings and memory performance for emotional information. | Spalek K et al. | — | 2019 | → |
| Work Fatigue in a Non-Deployed Military Setting: Assessment, Prevalence, Predictors, and Outcomes. | Frone MR et al. | — | 2019 | → |
| A Blood Test for Alzheimer's Disease: Progress, Challenges, and Recommendations. | Kiddle SJ et al. | — | 2018 | → |
| An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder. | Werling DM et al. | — | 2018 | → |
| An Assessment of the Cox Proportional Hazards Regression Model for Epidemiologic Studies. | Moolgavkar SH et al. | — | 2018 | → |
| Association of Apathy With Risk of Incident Dementia: A Systematic Review and Meta-analysis. | van Dalen JW et al. | — | 2018 | → |
| A statistic to avoid being misled by the "winners curse". | Tugwell P et al. | — | 2018 | → |
| Brief Report: Exercise and Anxiety in Adults with Arthritis and Other Rheumatic Diseases: Support for Evidential Value. | Kelley GA et al. | — | 2018 | → |
| Circulating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort. | van Roekel EH et al. | — | 2018 | → |
| Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. | Culverhouse RC et al. | — | 2018 | → |
| Comparison of treatment effect sizes from pivotal and postapproval trials of novel therapeutics approved by the FDA based on surrogate markers of disease: a meta-epidemiological study. | Wallach JD et al. | — | 2018 | → |
| Consequences of relying on statistical significance: Some illustrations. | Van Calster B et al. | — | 2018 | → |
| Cross-validation failure: Small sample sizes lead to large error bars. | Varoquaux G | — | 2018 | → |
| Cultural effects on computational metrics of spatial and temporal context. | Wright ND et al. | — | 2018 | → |
| Design analysis indicates Potential overestimation of treatment effects in randomized controlled trials supporting Food and Drug Administration cancer drug approvals. | Lord EM et al. | — | 2018 | → |
| Effect size and statistical power in the rodent fear conditioning literature - A systematic review. | Carneiro CFD et al. | — | 2018 | → |
| Effects of the Ser326Cys Polymorphism in the DNA Repair OGG1 Gene on Cancer, Cardiovascular, and All-Cause Mortality in the PREDIMED Study: Modulation by Diet. | Corella D et al. | — | 2018 | → |
| Electroconvulsive Therapy for Agitation and Aggression in Dementia: A Systematic Review. | van den Berg JF et al. | — | 2018 | → |
| Electrophysiological Correlates of Absolute Pitch in a Passive Auditory Oddball Paradigm: a Direct Replication Attempt. | Greber M et al. | — | 2018 | → |
| Evaluating the replicability of social science experiments in Nature and Science between 2010 and 2015. | Camerer CF et al. | — | 2018 | → |
| Fluid therapy in neurointensive care patients: ESICM consensus and clinical practice recommendations. | Oddo M et al. | — | 2018 | → |
| Four reasons to prefer Bayesian analyses over significance testing. | Dienes Z et al. | — | 2018 | → |
| Four simple ways to increase power without increasing the sample size. | Lazic SE | — | 2018 | → |
| Gene annotation bias impedes biomedical research. | Haynes WA et al. | — | 2018 | → |
| Genetic and non-genetic risk factors for pre-eclampsia: umbrella review of systematic reviews and meta-analyses of observational studies. | Giannakou K et al. | — | 2018 | → |
| Homeopathic <i>Arnica</i> from Boiron and post-operative bleeding in mastectomized women in Milan: Statistical flaws and bias to be addressed. | Chirumbolo S et al. | — | 2018 | → |
| How often should we expect to be wrong? Statistical power, P values, and the expected prevalence of false discoveries. | Marino MJ | — | 2018 | → |
| How Routinely Collected Data for Randomized Trials Provide Long-term Randomized Real-World Evidence. | Hemkens LG | — | 2018 | → |
| Interventions for preventing high altitude illness: Part 2. Less commonly-used drugs. | Gonzalez Garay A et al. | — | 2018 | → |
| Methodological and reporting quality in laboratory studies of human eating behavior. | Robinson E et al. | — | 2018 | → |
| No Evidence That Frontal Eye Field tDCS Affects Latency or Accuracy of Prosaccades. | Reteig LC et al. | — | 2018 | → |
| Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival. | Hornshøj H et al. | — | 2018 | → |
| Performance of informative priors skeptical of large treatment effects in clinical trials: A simulation study. | Pedroza C et al. | — | 2018 | → |
| Personalized evidence based medicine: predictive approaches to heterogeneous treatment effects. | Kent DM et al. | — | 2018 | → |
| Poor performance of clinical prediction models: the harm of commonly applied methods. | Steyerberg EW et al. | — | 2018 | → |
| Predicting Violent Behavior: What Can Neuroscience Add? | Poldrack RA et al. | — | 2018 | → |
| Randomized clinical trials and observational studies in the assessment of drug safety. | Sawchik J et al. | — | 2018 | → |
| Randomized Controlled Trial of Acupuncture for Women with Fibromyalgia: Group Acupuncture with Traditional Chinese Medicine Diagnosis-Based Point Selection. | Mist SD et al. | — | 2018 | → |
| Reducing procrastination using a smartphone-based treatment program: A randomized controlled pilot study. | Lukas CA et al. | — | 2018 | → |
| Reply: POLR3A variants in hereditary spastic paraplegia and ataxia. | Minnerop M et al. | — | 2018 | → |
| Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): An Abridged Explanation and Elaboration. | Sauerbrei W et al. | — | 2018 | → |
| Reprint of "Methodological and reporting quality in laboratory studies of human eating behavior". | Robinson E et al. | — | 2018 | → |
| Resting-state functional brain connectivity best predicts the personality dimension of openness to experience. | Dubois J et al. | — | 2018 | → |
| Statins and Multiple Noncardiovascular Outcomes: Umbrella Review of Meta-analyses of Observational Studies and Randomized Controlled Trials. | He Y et al. | — | 2018 | → |
| Statistical Power in Plant Pathology Research. | Gent DH et al. | — | 2018 | → |
| Telemedical monitoring of patients with chronic heart failure has a positive effect on total health costs. | Herold R et al. | — | 2018 | → |
| The association between body mass index and the risk of different gastrointestinal cancers: A protocol for an overview of systematic reviews. | Ma X et al. | — | 2018 | → |
| The continuing misuse of null hypothesis significance testing in biological anthropology. | Smith RJ | — | 2018 | → |
| The Impact of lncRNA Dysregulation on Clinicopathology and Survival of Breast Cancer: A Systematic Review and Meta-analysis. | Tian T et al. | — | 2018 | → |
| The impact of sample size on the reproducibility of voxel-based lesion-deficit mappings. | Lorca-Puls DL et al. | — | 2018 | → |
| The Influence of Co-action on a Simple Attention Task: A Shift Back to the Status Quo. | Dosso JA et al. | — | 2018 | → |
| The number of FoxP3 regulatory T cells in the circulation may be a predictive biomarker for kidney transplant recipients: A multistage systematic review. | Herrera-Gómez F et al. | — | 2018 | → |
| The replication crisis in epidemiology: snowball, snow job, or winter solstice? | Lash TL et al. | — | 2018 | → |
| Using Bayes factors to evaluate evidence for no effect: examples from the SIPS project. | Dienes Z et al. | — | 2018 | → |
| Using microRNAs as Novel Predictors of Urologic Cancer Survival: An Integrated Analysis. | Chen Z et al. | — | 2018 | → |
| What Happened to the Employed During the Great Recession? A U.S. Population Study of Net Change in Employee Insecurity, Health, and Organizational Commitment. | Frone MR | — | 2018 | → |
| Why replication has more scientific value than original discovery. | Ioannidis JPA | — | 2018 | → |
| Why sample size estimates? | Weber EJ et al. | — | 2018 | → |
| Adiposity and cancer at major anatomical sites: umbrella review of the literature. | Kyrgiou M et al. | — | 2017 | → |
| Adults with autism overestimate the volatility of the sensory environment. | Lawson RP et al. | — | 2017 | → |
| A likelihood-based approach to P-value interpretation provided a novel, plausible, and clinically useful research study metric. | Adams NG et al. | — | 2017 | → |
| An Association Between ICP-Derived Data and Outcome in TBI Patients: The Role of Sample Size. | Cabella B et al. | — | 2017 | → |
| Bayesian evaluation of effect size after replicating an original study. | van Aert RC et al. | — | 2017 | → |
| Biases in Randomized Trials: A Conversation Between Trialists and Epidemiologists. | Mansournia MA et al. | — | 2017 | → |
| Carcinogenic effects of oil dispersants: A KEGG pathway-based RNA-seq study of human airway epithelial cells. | Liu YZ et al. | — | 2017 | → |
| Choosing Prediction Over Explanation in Psychology: Lessons From Machine Learning. | Yarkoni T et al. | — | 2017 | → |
| Circulating Levels of Interleukin 1-Receptor Antagonist and Risk of Cardiovascular Disease: Meta-Analysis of Six Population-Based Cohorts. | Herder C et al. | — | 2017 | → |
| Condom-Insistence Conflict in Women's Alcohol-Involved Sexual Encounters with a New Male Partner. | Bryan AEB et al. | — | 2017 | → |
| Confidence crisis of results in biomechanics research. | Knudson D | — | 2017 | → |
| CORP: Minimizing the chances of false positives and false negatives. | Curran-Everett D | — | 2017 | → |
| Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases. | McAllister K et al. | — | 2017 | → |
| Does psychotherapy work? An umbrella review of meta-analyses of randomized controlled trials. | Dragioti E et al. | — | 2017 | → |
| Does Self-Control Training Improve Self-Control? A Meta-Analysis. | Friese M et al. | — | 2017 | → |
| Empirical assessment of published effect sizes and power in the recent cognitive neuroscience and psychology literature. | Szucs D et al. | — | 2017 | → |
| Endophenotype best practices. | Iacono WG et al. | — | 2017 | → |
| Environment, susceptibility windows, development, and child health. | Wright RO | — | 2017 | → |
| Experimental animal models of Parkinson's disease: A transition from assessing symptomatology to α-synuclein targeted disease modification. | Ko WKD et al. | — | 2017 | → |
| For and Against Methodologies: Some Perspectives on Recent Causal and Statistical Inference Debates. | Greenland S | — | 2017 | → |
| Gene Linkage and Systems Biology. | Cookson MR | — | 2017 | → |
| Genome-wide association scan of neuropathic pain symptoms post total joint replacement highlights a variant in the protein-kinase C gene. | Warner SC et al. | — | 2017 | → |
| Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. | Justice AE et al. | — | 2017 | → |
| Guidance on the assessment of the biological relevance of data in scientific assessments. | EFSA Scientific Committee et al. | — | 2017 | → |
| Health technology assessments conducted in health care facilities: A strategic practice? Findings from a content analysis of HTA reports. | Ouimet M et al. | — | 2017 | → |
| Human Fear Chemosignaling: Evidence from a Meta-Analysis. | de Groot JHB et al. | — | 2017 | → |
| If Only my Leader Would just Do Something! Passive Leadership Undermines Employee Well-being Through Role Stressors and Psychological Resource Depletion. | Barling J et al. | — | 2017 | → |
| Improving the rigor of psychophysiology research. | Baldwin SA | — | 2017 | → |
| Integrity of Literature on Expressed Emotion and Relapse in Patients with Schizophrenia Verified by a p-Curve Analysis. | Weintraub MJ et al. | — | 2017 | → |
| Intranasal Oxytocin May Improve High-Level Social Cognition in Schizophrenia, But Not Social Cognition or Neurocognition in General: A Multilevel Bayesian Meta-analysis. | Bürkner PC et al. | — | 2017 | → |
| Investigating the work-family conflict and health link: Repetitive thought as a mechanism. | Davis KD et al. | — | 2017 | → |
| Is structural stigma's effect on the mortality of sexual minorities robust? A failure to replicate the results of a published study. | Regnerus M | — | 2017 | → |
| Liver Metastasectomy and Systemic Therapy Improve Overall Survival Compared With Surgery Alone After Curative Liver Resection of Colorectal Metastases in a Developing Country (Costa Rica). | Quesada-Soto P et al. | — | 2017 | → |
| Maternal alcohol use during pregnancy and offspring attention-deficit hyperactivity disorder (ADHD): a prospective sibling control study. | Eilertsen EM et al. | — | 2017 | → |
| Neutrophil-to-lymphocyte ratio as a bladder cancer biomarker: Assessing prognostic and predictive value in SWOG 8710. | Ojerholm E et al. | — | 2017 | → |
| New drug developments in psychosis: Challenges, opportunities and strategies. | Keshavan MS et al. | — | 2017 | → |
| No evidential value in samples of transcranial direct current stimulation (tDCS) studies of cognition and working memory in healthy populations. | Medina J et al. | — | 2017 | → |
| Nonsteroidal anti-inflammatory drugs may affect cytokine response and benefit healing of combat-related extremity wounds. | Lisboa FA et al. | — | 2017 | → |
| Obesity and gynaecological and obstetric conditions: umbrella review of the literature. | Kalliala I et al. | — | 2017 | → |
| Overlapping network meta-analyses on the same topic: survey of published studies. | Naudet F et al. | — | 2017 | → |
| Per-Protocol Analyses of Pragmatic Trials. | Hernán MA et al. | — | 2017 | → |
| Physical and mental health of children with substantiated sexual abuse: Gender comparisons from a matched-control cohort study. | Daigneault I et al. | — | 2017 | → |
| Publishing replication studies to support excellence in physiological research. | McLoughlin P et al. | — | 2017 | → |
| Questionable science and reproducibility in electrical brain stimulation research. | Héroux ME et al. | — | 2017 | → |
| Research Pearls: The Significance of Statistics and Perils of Pooling. Part 3: Pearls and Pitfalls of Meta-analyses and Systematic Reviews. | Harris JD et al. | — | 2017 | → |
| Rigor and replication: Toward improved best practices in human electrophysiology research. | Larson MJ et al. | — | 2017 | → |
| Sample size calculations in human electrophysiology (EEG and ERP) studies: A systematic review and recommendations for increased rigor. | Larson MJ et al. | — | 2017 | → |
| Social Decision-Making and the Brain: A Comparative Perspective. | Tremblay S et al. | — | 2017 | → |
| Social, Psychological, And Physical Aspects Of The Work Environment Could Contribute To Hypertension Prevalence. | Rehkopf DH et al. | — | 2017 | → |
| Statistical considerations for reporting and planning heart rate variability case-control studies. | Quintana DS | — | 2017 | → |
| Systematic review and meta-analysis of genetic studies of late-life depression. | Tsang RS et al. | — | 2017 | → |
| The earth is flat (<i>p</i> > 0.05): significance thresholds and the crisis of unreplicable research. | Amrhein V et al. | — | 2017 | → |
| The Genomic Architecture of Flowering Time Varies Across Space and Time in <i>Mimulus guttatus</i>. | Monnahan PJ et al. | — | 2017 | → |
| The relation between statistical power and inference in fMRI. | Cremers HR et al. | — | 2017 | → |
| The Weak Spots in Contemporary Science (and How to Fix Them). | Wicherts JM | — | 2017 | → |
| When Null Hypothesis Significance Testing Is Unsuitable for Research: A Reassessment. | Szucs D et al. | — | 2017 | → |
| White matter structural network abnormalities underlie executive dysfunction in amyotrophic lateral sclerosis. | Dimond D et al. | — | 2017 | → |
| Why prudence is needed when interpreting articles reporting clinical trial results in mental health. | Dal-Ré R et al. | — | 2017 | → |
| A Bayesian Perspective on the Reproducibility Project: Psychology. | Etz A et al. | — | 2016 | → |
| Abundant contribution of short tandem repeats to gene expression variation in humans. | Gymrek M et al. | — | 2016 | → |
| A Hitchhiker's Guide to Functional Magnetic Resonance Imaging. | Soares JM et al. | — | 2016 | → |
| A new method for estimating effect size distribution and heritability from genome-wide association summary results. | Zhang L et al. | — | 2016 | → |
| Anticipating consequences of sharing raw data and code and of awarding badges for sharing. | Ioannidis JP | — | 2016 | → |
| Association between Parkinson's Disease and Cigarette Smoking, Rural Living, Well-Water Consumption, Farming and Pesticide Use: Systematic Review and Meta-Analysis. | Breckenridge CB et al. | — | 2016 | → |
| A Tutorial on Hunting Statistical Significance by Chasing <i>N</i>. | Szucs D | — | 2016 | → |
| Can the behavioral sciences self-correct? A social epistemic study. | Romero F | — | 2016 | → |
| Conducting Meta-Analyses Based on p Values: Reservations and Recommendations for Applying p-Uniform and p-Curve. | van Aert RC et al. | — | 2016 | → |
| Covariate adjustments in randomized controlled trials increased study power and reduced biasedness of effect size estimation. | Lee PH | — | 2016 | → |
| Degrees of Freedom in Planning, Running, Analyzing, and Reporting Psychological Studies: A Checklist to Avoid <i>p</i>-Hacking. | Wicherts JM et al. | — | 2016 | → |
| Detection of Allelic Frequency Differences between the Sexes in Humans: A Signature of Sexually Antagonistic Selection. | Lucotte EA et al. | — | 2016 | → |
| Ecological characteristics and in situ genetic associations for yield-component traits of wild Miscanthus from eastern Russia. | Clark LV et al. | — | 2016 | → |
| Environment-Wide Association Study of Blood Pressure in the National Health and Nutrition Examination Survey (1999-2012). | McGinnis DP et al. | — | 2016 | → |
| Evaluating replicability of laboratory experiments in economics. | Camerer CF et al. | — | 2016 | → |
| Evaluation of results from genome-wide studies of language and reading in a novel independent dataset. | Carrion-Castillo A et al. | — | 2016 | → |
| Examining non-syndromic autosomal recessive intellectual disability (NS-ARID) genes for an enriched association with intelligence differences. | Hill WD et al. | — | 2016 | → |
| Exercise reduces depressive symptoms in adults with arthritis: Evidential value. | Kelley GA et al. | — | 2016 | → |
| Explorations in statistics: statistical facets of reproducibility. | Curran-Everett D | — | 2016 | → |
| Field-wide meta-analyses of observational associations can map selective availability of risk factors and the impact of model specifications. | Serghiou S et al. | — | 2016 | → |
| Genomic evidence that resource-based trade-offs limit host-range expansion in a seed beetle. | Gompert Z et al. | — | 2016 | → |
| How to Interpret a Negative Study. | Leontiadis GI | — | 2016 | → |
| Long noncoding RNAs as novel predictors of survival in human cancer: a systematic review and meta-analysis. | Serghiou S et al. | — | 2016 | → |
| Long-Term Effects of Frequent In-Center Hemodialysis. | Chertow GM et al. | — | 2016 | → |
| Magnetic Resonance Spectroscopy in Patients with Insomnia: A Repeated Measurement Study. | Spiegelhalder K et al. | — | 2016 | → |
| Measuring the Prevalence of Problematic Respondent Behaviors among MTurk, Campus, and Community Participants. | Necka EA et al. | — | 2016 | → |
| NIH Peer Review: Scored Review Criteria and Overall Impact. | Lindner MD et al. | — | 2016 | → |
| Optimizing Research Payoff. | Miller J et al. | — | 2016 | → |
| Paracelsus Revisited: The Dose Concept in a Complex World. | Grandjean P | — | 2016 | → |
| p-Curve and p-Hacking in Observational Research. | Bruns SB et al. | — | 2016 | → |
| Pharmacological interventions for treating heart failure in patients with Chagas cardiomyopathy. | Martí-Carvajal AJ et al. | — | 2016 | → |
| Power estimation and sample size determination for replication studies of genome-wide association studies. | Jiang W et al. | — | 2016 | → |
| Reclassification of genetic-based risk predictions as GWAS data accumulate. | Krier J et al. | — | 2016 | → |
| Registration practices for observational studies on ClinicalTrials.gov indicated low adherence. | Boccia S et al. | — | 2016 | → |
| Replication Validity of Initial Association Studies: A Comparison between Psychiatry, Neurology and Four Somatic Diseases. | Dumas-Mallet E et al. | — | 2016 | → |
| Self-perceived cognitive deficits and their relationship with internalized stigma and quality of life in patients with schizophrenia. | Shin YJ et al. | — | 2016 | → |
| Sports genetics moving forward: lessons learned from medical research. | Mattsson CM et al. | — | 2016 | → |
| Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies. | Walum H et al. | — | 2016 | → |
| Statistical Inference for Data Adaptive Target Parameters. | Hubbard AE et al. | — | 2016 | → |
| Systematic assessment of pharmaceutical prescriptions in association with cancer risk: a method to conduct a population-wide medication-wide longitudinal study. | Patel CJ et al. | — | 2016 | → |
| Systematic Review and Meta-Analysis of Tacrolimus versus Ciclosporin as Primary Immunosuppression After Liver Transplant. | Muduma G et al. | — | 2016 | → |
| Systematic Review: Issues in Measuring Clinically Meaningful Change in Self-Reported Chronic Pediatric Pain Intensity. | Lavigne JV | — | 2016 | → |
| Systematic review of blood transcriptome profiling in neuropsychiatric disorders: guidelines for biomarker discovery. | Breen MS et al. | — | 2016 | → |
| Tests for Gene-Environment Interactions and Joint Effects With Exposure Misclassification. | Boonstra PS et al. | — | 2016 | → |
| The latent structure of psychiatric symptoms across mental disorders as measured with the PANSS and BPRS-18. | Van Dorn RA et al. | — | 2016 | → |
| Use of the "Exposome" in the Practice of Epidemiology: A Primer on -Omic Technologies. | DeBord DG et al. | — | 2016 | → |
| What do we know about children living with HIV-infected or AIDS-ill adults in Sub-Saharan Africa? A systematic review of the literature. | Goldberg RE et al. | — | 2016 | → |
| Work Stress and Alcohol Use: Developing and Testing a Biphasic Self-Medication Model. | Frone MR | — | 2016 | → |
| A Meta-Analytic Review of Stand-Alone Interventions to Improve Body Image. | Alleva JM et al. | — | 2015 | → |
| Antibiotics for treating acute chest syndrome in people with sickle cell disease. | Martí-Carvajal AJ et al. | — | 2015 | → |
| Assessment of vibration of effects due to model specification can demonstrate the instability of observational associations. | Patel CJ et al. | — | 2015 | → |
| Associations of PER3 and RORA Circadian Gene Polymorphisms and Depressive Symptoms in Older Adults. | Maglione JE et al. | — | 2015 | → |
| Atrial fibrillation ablation, sinus rhythm, and cardiovascular mortality. | Littmann L | — | 2015 | → |
| Attention bias modification for social anxiety: A systematic review and meta-analysis. | Heeren A et al. | — | 2015 | → |
| Biomarkers of Inflammation and Immune Function and Risk of Colorectal Cancer. | Garcia-Anguita A et al. | — | 2015 | → |
| Color and psychological functioning: a review of theoretical and empirical work. | Elliot AJ | — | 2015 | → |
| Developing Peripheral Blood Gene Expression-Based Diagnostic Tests for Coronary Artery Disease: a Review. | Rhees B et al. | — | 2015 | → |
| Does bad inference drive out good? | Marozzi M | — | 2015 | → |
| Does Statistics Matter? | Kivelä JM | — | 2015 | → |
| Efficacy of cognitive bias modification interventions in anxiety and depression: meta-analysis. | Cristea IA et al. | — | 2015 | → |
| Epidemiologic research with administrative databases: red herrings, false alarms and pseudo-epidemics. | Grimes DA | — | 2015 | → |
| Ethical Considerations for Increased Transparency and Reproducibility in the Retrospective Analysis of Health Care Data. | Rotelli MD | — | 2015 | → |
| Evidential Value That Exercise Improves BMI z-Score in Overweight and Obese Children and Adolescents. | Kelley GA et al. | — | 2015 | → |
| Examining the Predictive Validity of NIH Peer Review Scores. | Lindner MD et al. | — | 2015 | → |
| Genetics of Sleep Disorders. | Gehrman PR et al. | — | 2015 | → |
| Genetic variability in ABCB1, occupational pesticide exposure, and Parkinson's disease. | Narayan S et al. | — | 2015 | → |
| Genome-wide association study for claw disorders and trimming status in dairy cattle. | van der Spek D et al. | — | 2015 | → |
| Guidelines for translational research in heart failure. | Lara-Pezzi E et al. | — | 2015 | → |
| Improving teacher-child relationship quality and teacher-rated behavioral adjustment amongst externalizing preschoolers: effects of a two-component intervention. | Vancraeyveldt C et al. | — | 2015 | → |
| Involvement of GPR50 polymorphisms in depression: independent replication in a prospective elderly cohort. | Ryan J et al. | — | 2015 | → |
| Janus kinase-1 and Janus kinase-2 inhibitors for treating myelofibrosis. | Martí-Carvajal AJ et al. | — | 2015 | → |
| Long-term Effects of Frequent Nocturnal Hemodialysis on Mortality: The Frequent Hemodialysis Network (FHN) Nocturnal Trial. | Rocco MV et al. | — | 2015 | → |
| Message generalizations that support evidence-based persuasive message design: specifying the evidentiary requirements. | O'Keefe DJ | — | 2015 | → |
| Meta-analyses triggered by previous (false-)significant findings: problems and solutions. | Schuit E et al. | — | 2015 | → |
| MR-PheWAS: hypothesis prioritization among potential causal effects of body mass index on many outcomes, using Mendelian randomization. | Millard LA et al. | — | 2015 | → |
| No association between polygenic risk for schizophrenia and brain volume in the general population. | Van der Auwera S et al. | — | 2015 | → |
| Oral contraceptives and cognition: A role for ethinyl estradiol. | Beltz AM et al. | — | 2015 | → |
| Protocol registration and selective outcome reporting in recent psychiatry trials: new antidepressants and cognitive behavioural therapies. | Shinohara K et al. | — | 2015 | → |
| Relations of negative and positive work experiences to employee alcohol use: testing the intervening role of negative and positive work rumination. | Frone MR | — | 2015 | → |
| Replicating studies in which samples of participants respond to samples of stimuli. | Westfall J et al. | — | 2015 | → |
| Replication and contradiction of highly cited research papers in psychiatry: 10-year follow-up. | Tajika A et al. | — | 2015 | → |
| Sex-dependent dissociation between emotional appraisal and memory: a large-scale behavioral and fMRI study. | Spalek K et al. | — | 2015 | → |
| Small studies are more heterogeneous than large ones: a meta-meta-analysis. | IntHout J et al. | — | 2015 | → |
| Small telescopes: detectability and the evaluation of replication results. | Simonsohn U | — | 2015 | → |
| Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls. | Fortune MD et al. | — | 2015 | → |
| The meaning and measurement of work fatigue: Development and evaluation of the Three-Dimensional Work Fatigue Inventory (3D-WFI). | Frone MR et al. | — | 2015 | → |
| The sun is not hurried by early risers. | Evers JL | — | 2015 | → |
| The Thin Reed: Accommodating Weak Evidence for Critical Parameters in Cost-Benefit Analysis. | Weimer DL | — | 2015 | → |
| The Use and Abuse of Transcranial Magnetic Stimulation to Modulate Corticospinal Excitability in Humans. | Héroux ME et al. | — | 2015 | → |
| Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD): explanation and elaboration. | Moons KG et al. | — | 2015 | → |
| Understanding the candidate gene × environment interaction debate: epistemological or evidential divide? | Munafò MR | — | 2015 | → |
| Why bother using non-human primate models of cognitive disorders in translational research? | Camus S et al. | — | 2015 | → |
| Additive interactions between susceptibility single-nucleotide polymorphisms identified in genome-wide association studies and breast cancer risk factors in the Breast and Prostate Cancer Cohort Consortium. | Joshi AD et al. | — | 2014 | → |
| A failed attempt to conduct an individual patient data meta-analysis. | Jaspers GJ et al. | — | 2014 | → |
| A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation. | Psychosis Endophenotypes International Consortium et al. | — | 2014 | → |
| A meta-analytic review of psychodynamic therapies for anxiety disorders. | Keefe JR et al. | — | 2014 | → |
| Animal models of Huntington's disease for translation to the clinic: best practices. | Menalled L et al. | — | 2014 | → |
| A note regarding meta-analysis of sequential trials with stopping for efficacy. | Senn S | — | 2014 | → |
| Bayesian systems-based genetic association analysis with effect strength estimation and omic wide interpretation: a case study in rheumatoid arthritis. | Hullám G et al. | — | 2014 | → |
| Body mass index categories in observational studies of weight and risk of death. | Flegal KM et al. | — | 2014 | → |
| Characterisation of adaptive genetic diversity in environmentally contrasted populations of Eucalyptus camaldulensis Dehnh. (river red gum). | Dillon S et al. | — | 2014 | → |
| Comparing the accuracy of experimental estimates to guessing: a new perspective on replication and the "Crisis of Confidence" in psychology. | Davis-Stober CP et al. | — | 2014 | → |
| Cost-efficiency of knowledge creation: randomized controlled trials vs. observational studies. | Struck R et al. | — | 2014 | → |
| Critical evaluation of auditory event-related potential deficits in schizophrenia: evidence from large-scale single-subject pattern classification. | Neuhaus AH et al. | — | 2014 | → |
| Design and Analysis for Studying microRNAs in Human Disease: A Primer on -Omic Technologies. | Nair VS et al. | — | 2014 | → |
| Discussion: Why "An estimate of the science-wise false discovery rate and application to the top medical literature" is false. | Ioannidis JP | — | 2014 | → |
| Effects of depression, anxiety, comorbidity, and antidepressants on resting-state heart rate and its variability: an ELSA-Brasil cohort baseline study. | Kemp AH et al. | — | 2014 | → |
| Effects of interventions on survival in acute respiratory distress syndrome: an umbrella review of 159 published randomized trials and 29 meta-analyses. | Tonelli AR et al. | — | 2014 | → |
| Elaborate visual and acoustic signals evolve independently in a large, phenotypically diverse radiation of songbirds. | Mason NA et al. | — | 2014 | → |
| Elective, major noncardiac surgery on the weekend: a population-based cohort study of 30-day mortality. | McIsaac DI et al. | — | 2014 | → |
| Epidemiology as a liberal art: from graduate school to middle school, an unfulfilled agenda. | Bracken MB | — | 2014 | → |
| Evolution of the empirical and theoretical foundations of eyewitness identification reform. | Clark SE et al. | — | 2014 | → |
| Familial liability to psychosis is associated with attenuated dopamine stress signaling in ventromedial prefrontal cortex. | Lataster J et al. | — | 2014 | → |
| Fat chance! | Evers JL | — | 2014 | → |
| Flaws in animal studies exploring statins and impact on meta-analysis. | Moja L et al. | — | 2014 | → |
| Functional analysis of variance for association studies. | Vsevolozhskaya OA et al. | — | 2014 | → |
| Genetics, neuroscience, and psychopathology: clothing the emperor. | Patrick CJ | — | 2014 | → |
| Genome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus. | Oei L et al. | — | 2014 | → |
| Genome-wide scans of genetic variants for psychophysiological endophenotypes: introduction to this special issue of Psychophysiology. | Iacono WG | — | 2014 | → |
| Genome-wide screening for DNA variants associated with reading and language traits. | Gialluisi A et al. | — | 2014 | → |
| How to make more published research true. | Ioannidis JP | — | 2014 | → |
| Increasing value and reducing waste in research design, conduct, and analysis. | Ioannidis JP et al. | — | 2014 | → |
| Lying (or Maybe Just Misleading) With (or Without) Statistics. | Baranowski T | — | 2014 | → |
| Making big data open: data sharing in neuroimaging. | Poldrack RA et al. | — | 2014 | → |
| Making prospective registration of observational research a reality. | Dal-Ré R et al. | — | 2014 | → |
| Mendelian randomization in health research: using appropriate genetic variants and avoiding biased estimates. | Taylor AE et al. | — | 2014 | → |
| Nonindustry-sponsored preclinical studies on statins yield greater efficacy estimates than industry-sponsored studies: a meta-analysis. | Krauth D et al. | — | 2014 | → |
| Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants. | Sayols-Baixeras S et al. | — | 2014 | → |
| p-Curve and Effect Size: Correcting for Publication Bias Using Only Significant Results. | Simonsohn U et al. | — | 2014 | → |
| Placing epidemiological results in the context of multiplicity and typical correlations of exposures. | Patel CJ et al. | — | 2014 | → |
| Potential increased risk of cancer from commonly used medications: an umbrella review of meta-analyses. | Ioannidis JP et al. | — | 2014 | → |
| Publication and other reporting biases in cognitive sciences: detection, prevalence, and prevention. | Ioannidis JP et al. | — | 2014 | → |
| Putting value in biomarker research and reporting. | Mischak H et al. | — | 2014 | → |
| Refinement of experimental design and conduct in laboratory animal research. | Bailoo JD et al. | — | 2014 | → |
| Reliable gains? Evidence for substantially underpowered designs in studies of working memory training transfer to fluid intelligence. | Bogg T et al. | — | 2014 | → |
| Results of observational studies: analysis of findings from the Nurses' Health Study. | Tai V et al. | — | 2014 | → |
| Sedation depth and mortality: a large randomized trial is required. | Leslie K et al. | — | 2014 | → |
| Statistical power and significance testing in large-scale genetic studies. | Sham PC et al. | — | 2014 | → |
| Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically. | Sena ES et al. | — | 2014 | → |
| Systematic review with meta-analysis: highly selective 5-HT4 agonists (prucalopride, velusetrag or naronapride) in chronic constipation. | Shin A et al. | — | 2014 | → |
| The shrinking or disappearing observed treatment effect. | Chuang-Stein C et al. | — | 2014 | → |
| The use and misuse of statistical methodologies in pharmacology research. | Marino MJ | — | 2014 | → |
| When decision heuristics and science collide. | Yu EC et al. | — | 2014 | → |
| Why publishing everything is more effective than selective publishing of statistically significant results. | van Assen MA et al. | — | 2014 | → |
| A discovery study of daunorubicin induced cardiotoxicity in a sample of acute myeloid leukemia patients prioritizes P450 oxidoreductase polymorphisms as a potential risk factor. | Lubieniecka JM et al. | — | 2013 | → |
| An environmental wide association study (EWAS) approach to the metabolic syndrome. | Lind PM et al. | — | 2013 | → |
| Antibiotics for treating acute chest syndrome in people with sickle cell disease. | Martí-Carvajal AJ et al. | — | 2013 | → |
| A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems. | Groen-Blokhuis MM et al. | — | 2013 | → |
| Assessment of systematic effects of methodological characteristics on candidate genetic associations. | Aljasir B et al. | — | 2013 | → |
| Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. | Flegal KM et al. | — | 2013 | → |
| Bibliometric Evidence for a Hierarchy of the Sciences. | Fanelli D et al. | — | 2013 | → |
| Big data in epidemiology: too big to fail? | Chiolero A | — | 2013 | → |
| Brief critical review: Statistical assessment of biomarker performance. | Kampfrath T et al. | — | 2013 | → |
| Cancer pharmacogenomics: strategies and challenges. | Wheeler HE et al. | — | 2013 | → |
| Challenges in the development of an immunochromatographic interferon-gamma test for diagnosis of pleural tuberculosis. | Denkinger CM et al. | — | 2013 | → |
| Common genetic variants in ARNTL and NPAS2 and at chromosome 12p13 are associated with objectively measured sleep traits in the elderly. | Evans DS et al. | — | 2013 | → |
| Decline in placebo-controlled trial results suggests new directions for comparative effectiveness research. | Olfson M et al. | — | 2013 | → |
| Evaluation of excess significance bias in animal studies of neurological diseases. | Tsilidis KK et al. | — | 2013 | → |
| False positives in cancer epidemiology. | McLaughlin JK et al. | — | 2013 | → |
| Impacts and interactions of PDGFRB, MMP-3, TIMP-2, and RNF213 polymorphisms on the risk of Moyamoya disease in Han Chinese human subjects. | Wang X et al. | — | 2013 | → |
| Is everything we eat associated with cancer? A systematic cookbook review. | Schoenfeld JD et al. | — | 2013 | → |
| Nicotinic acetylcholine receptor variation and response to smoking cessation therapies. | Bergen AW et al. | — | 2013 | → |
| On genome-wide association studies and their meta-analyses: lessons learned from osteoporosis studies. | Liu YJ et al. | — | 2013 | → |
| Polymorphisms in ACVRL1 and endoglin genes are not associated with sporadic and HHT-related brain AVMs in Dutch patients. | Boshuisen K et al. | — | 2013 | → |
| Postconditioning during percutaneous coronary intervention in acute myocardial infarction: continued difficulty in translation. | Laskey WK et al. | — | 2013 | → |
| Power failure: why small sample size undermines the reliability of neuroscience. | Button KS et al. | — | 2013 | → |
| Practices and impact of primary outcome adjustment in randomized controlled trials: meta-epidemiologic study. | Saquib N et al. | — | 2013 | → |
| Systematic evaluation of environmental and behavioural factors associated with all-cause mortality in the United States national health and nutrition examination survey. | Patel CJ et al. | — | 2013 | → |
| The DRD4 exon III VNTR, bupropion, and associations with prospective abstinence. | Bergen AW et al. | — | 2013 | → |
| 'There and back again': revisiting the pathophysiological roles of human endogenous retroviruses in the post-genomic era. | Magiorkinis G et al. | — | 2013 | → |
| This I believe in genetics: discovery can be a nuisance, replication is science, implementation matters. | Ioannidis JP | — | 2013 | → |
| TREM2 and neurodegenerative disease. | Bertram L et al. | — | 2013 | → |
| TREM2 and neurodegenerative disease. | Jonsson T et al. | — | 2013 | → |
| TREM2 and neurodegenerative disease. | Benitez BA et al. | — | 2013 | → |
| TREM2 and neurodegenerative disease. | Bird TD | — | 2013 | → |
| TREM2 and neurodegenerative disease. | Guerreiro R et al. | — | 2013 | → |
| US studies may overestimate effect sizes in softer research. | Fanelli D et al. | — | 2013 | → |
| Vaccines for the common cold. | Simancas-Racines D et al. | — | 2013 | → |
| Why selective publication of statistically significant results can be effective. | de Winter J et al. | — | 2013 | → |
| A meta-analysis of coffee consumption and pancreatic cancer. | Turati F et al. | — | 2012 | → |
| Are we witnessing the decline effect in the Type D personality literature? What can be learned? | Coyne JC et al. | — | 2012 | → |
| Association of KIBRA with episodic and working memory: a meta-analysis. | Milnik A et al. | — | 2012 | → |
| Building the evidence base for decision making in cancer genomic medicine using comparative effectiveness research. | Goddard KA et al. | — | 2012 | → |
| Claims for improved survival from systemic corticosteroids in diverse conditions: an umbrella review. | Contopoulos-Ioannidis DG et al. | — | 2012 | → |
| Clinical utility of sequence-based genotype compared with that derivable from genotyping arrays. | Morgan AA et al. | — | 2012 | → |
| Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC). | Hein R et al. | — | 2012 | → |
| Elevated risk of preeclampsia in pregnant women with depression: depression or antidepressants? | Palmsten K et al. | — | 2012 | → |
| Evaluation of excess statistical significance in meta-analyses of 98 biomarker associations with cancer risk. | Tsilidis KK et al. | — | 2012 | → |
| False alarms and pseudo-epidemics: the limitations of observational epidemiology. | Grimes DA et al. | — | 2012 | → |
| Heritability in the genome-wide association era. | Zaitlen N et al. | — | 2012 | → |
| Multiplex meta-analysis of RNA expression to identify genes with variants associated with immune dysfunction. | Morgan AA et al. | — | 2012 | → |
| Negative results: why do they need to be published? | Sandercock P | — | 2012 | → |
| Perceived information gain from randomized trials correlates with publication in high-impact factor journals. | Evangelou E et al. | — | 2012 | → |
| Pharmacological interventions for treating heart failure in patients with chagas cardiomyopathy. | Hidalgo R et al. | — | 2012 | → |
| Primary study authors of significant studies are more likely to believe that a strong association exists in a heterogeneous meta-analysis compared with methodologists. | Panagiotou OA et al. | — | 2012 | → |
| Publication bias and the failure of replication in experimental psychology. | Francis G | — | 2012 | → |
| Punishment sensitivity modulates the processing of negative feedback but not error-induced learning. | Unger K et al. | — | 2012 | → |
| QTL linkage mapping of zebra finch beak color shows an oligogenic control of a sexually selected trait. | Schielzeth H et al. | — | 2012 | → |
| Quantifying prognosis with risk predictions. | Pace NL et al. | — | 2012 | → |
| Rate of change in carotid intima-media thickness and vascular events: meta-analyses can not solve all the issues. A point of view. | Bots ML et al. | — | 2012 | → |
| Reporting recommendations for tumor marker prognostic studies (REMARK): explanation and elaboration. | Altman DG et al. | — | 2012 | → |
| Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): explanation and elaboration. | Altman DG et al. | — | 2012 | → |
| Scientific inbreeding and same-team replication: type D personality as an example. | Ioannidis JP | — | 2012 | → |
| Statistical perspectives: all together NOT. | Hopkins WG et al. | — | 2012 | → |
| Systematic evaluation of environmental factors: persistent pollutants and nutrients correlated with serum lipid levels. | Patel CJ et al. | — | 2012 | → |
| The Psychology of Replication and Replication in Psychology. | Francis G | — | 2012 | → |
| The relative persuasiveness of gain- and loss-framed messages for promoting vaccination: a meta-analytic review. | O'Keefe DJ et al. | — | 2012 | → |
| The Rules of the Game Called Psychological Science. | Bakker M et al. | — | 2012 | → |
| The same old New Look: Publication bias in a study of wishful seeing. | Francis G | — | 2012 | → |
| Too good to be true: publication bias in two prominent studies from experimental psychology. | Francis G | — | 2012 | → |
| Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it? | Kapur S et al. | — | 2012 | → |
| Why Science Is Not Necessarily Self-Correcting. | Ioannidis JP | — | 2012 | → |
| Cryptic multiple hypotheses testing in linear models: overestimated effect sizes and the winner's curse. | Forstmeier W et al. | — | 2011 | → |
| Epidemiological fallacies of modern psychiatric research. | Newson RS et al. | — | 2011 | → |
| Evaluation of risk loci for schizophrenia derived from genome-wide association studies in a German population. | Schanze D et al. | — | 2011 | → |
| Genetics of schizophrenia: new findings and challenges. | Gejman PV et al. | — | 2011 | → |
| Guideline warfare over interventional therapies for low back pain: can we raise the level of discourse? | Chou R et al. | — | 2011 | → |
| Haematological interventions for treating disseminated intravascular coagulation during pregnancy and postpartum. | Martí-Carvajal AJ et al. | — | 2011 | → |
| IL-16 rs11556218 gene polymorphism is associated with coronary artery disease in the Chinese Han population. | Chen Y et al. | — | 2011 | → |
| Impact of phenotype definition on genome-wide association signals: empirical evaluation in human immunodeficiency virus type 1 infection. | Evangelou E et al. | — | 2011 | → |
| Magnitude of effects in clinical trials published in high-impact general medical journals. | Siontis KC et al. | — | 2011 | → |
| Quantifying selective reporting and the Proteus phenomenon for multiple datasets with similar bias. | Pfeiffer T et al. | — | 2011 | → |
| Risk factors and interventions with statistically significant tiny effects. | Siontis GC et al. | — | 2011 | → |
| Statistically significant meta-analyses of clinical trials have modest credibility and inflated effects. | Pereira TV et al. | — | 2011 | → |
| Statistical perspectives: all together not. | Hopkins WG et al. | — | 2011 | → |
| Statistical perspectives: all together NOT. | Hopkins WG et al. | — | 2011 | → |
| Statistical perspectives: all together NOT. | Hopkins WG et al. | — | 2011 | → |
| Statistical perspectives: all together NOT. | Hopkins WG et al. | — | 2011 | → |
| Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration. | Janssens AC et al. | — | 2011 | → |
| Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration. | Janssens AC et al. | — | 2011 | → |
| Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration. | Janssens AC et al. | — | 2011 | → |
| Strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS): explanation and elaboration. | Janssens AC et al. | — | 2011 | → |
| The association of remotely-sensed outdoor temperature with blood pressure levels in REGARDS: a cross-sectional study of a large, national cohort of African-American and white participants. | Kent ST et al. | — | 2011 | → |
| The false-positive to false-negative ratio in epidemiologic studies. | Ioannidis JP et al. | — | 2011 | → |
| Translating biomarkers to clinical practice. | Perlis RH | — | 2011 | → |
| Transparency of outcome reporting and trial registration of randomized controlled trials in top psychosomatic and behavioral health journals: A systematic review. | Milette K et al. | — | 2011 | → |
| Truths, associations, and hypotheses. | Kirpalani H et al. | — | 2011 | → |
| A compendium of genome-wide associations for cancer: critical synopsis and reappraisal. | Ioannidis JP et al. | — | 2010 | → |
| Assessing the performance of prediction models: a framework for traditional and novel measures. | Steyerberg EW et al. | — | 2010 | → |
| Bayesian bias adjustments of the lung cancer SMR in a cohort of German carbon black production workers. | Morfeld P et al. | — | 2010 | → |
| Cognitive neuroscience 2.0: building a cumulative science of human brain function. | Yarkoni T et al. | — | 2010 | → |
| Efficacy of Tai Chi for chronic musculoskeletal pain conditions: is the evidence ready for meta-analysis? Comment on the article by Hall et al. | Schieir O et al. | — | 2010 | → |
| Everything you never wanted to know about circular analysis, but were afraid to ask. | Kriegeskorte N et al. | — | 2010 | → |
| Generalized bone loss as a predictor of three-year radiographic damage in African American patients with recent-onset rheumatoid arthritis. | Zhang J et al. | — | 2010 | → |
| Genetic cardiovascular risk prediction: will we get there? | Thanassoulis G et al. | — | 2010 | → |
| Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review. | Panagiotou OA et al. | — | 2010 | → |
| Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study. | Suarez-Gestal M et al. | — | 2010 | → |
| Learning from the past: refining the way we study treatments. | Viechtbauer W | — | 2010 | → |
| Likelihood ratios for genome medicine. | Morgan AA et al. | — | 2010 | → |
| Meta-research: The art of getting it wrong. | Ioannidis JP | — | 2010 | → |
| Neurocognitive phenotypes and genetic dissection of disorders of brain and behavior. | Congdon E et al. | — | 2010 | → |
| Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study. | Evangelou E et al. | — | 2010 | → |
| P413L CHGB is not associated with ALS susceptibility or age at onset in a Dutch population. | van Vught PW et al. | — | 2010 | → |
| Personality in 100,000 Words: A large-scale analysis of personality and word use among bloggers. | Yarkoni T | — | 2010 | → |
| RASSF1A polymorphism in familial breast cancer. | Bergqvist J et al. | — | 2010 | → |
| Recommendations for biomarker identification and qualification in clinical proteomics. | Mischak H et al. | — | 2010 | → |
| Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies. | Siontis KC et al. | — | 2010 | → |
| Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence. | Wessel J et al. | — | 2010 | → |
| SNP-SNP interactions dominate the genetic architecture of candidate genes associated with left ventricular mass in African-Americans of the GENOA study. | Meyers KJ et al. | — | 2010 | → |
| The role of genetics in the etiology of schizophrenia. | Gejman PV et al. | — | 2010 | → |
| Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples. | Kell DB | — | 2010 | → |
| Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. | Scherag A et al. | — | 2010 | → |
| Vive les differences! Individual variation in neural mechanisms of executive control. | Braver TS et al. | — | 2010 | → |
| Web-based, participant-driven studies yield novel genetic associations for common traits. | Eriksson N et al. | — | 2010 | → |
| Would riluzole be efficacious in the new ALS trial design? | Verstraete E et al. | — | 2010 | → |
| Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility. | Dieguez-Gonzalez R et al. | — | 2009 | → |
| Anatomy of health effects of Mediterranean diet: Greek EPIC prospective cohort study. | Trichopoulou A et al. | — | 2009 | → |
| A new wave in the genetics of psychiatric disorders: the copy number variant tsunami. | Joober R et al. | — | 2009 | → |
| A plea for rigorous and honest science: false positive findings and biased presentations in epidemiological studies. | Morfeld P | — | 2009 | → |
| Beneficial effects of designed dietary fatty acid compositions on lipids in triacylglycerol-rich lipoproteins among Chinese patients with type 2 diabetes mellitus. | Dai J et al. | — | 2009 | → |
| Beyond odds ratios--communicating disease risk based on genetic profiles. | Kraft P et al. | — | 2009 | → |
| Carbon black and lung cancer-testing a novel exposure metric by multi-model inference. | Morfeld P et al. | — | 2009 | → |
| Common regulatory variation impacts gene expression in a cell type-dependent manner. | Dimas AS et al. | — | 2009 | → |
| Control selection options for genome-wide association studies in cohorts. | Wacholder S et al. | — | 2009 | → |
| Discovery properties of genome-wide association signals from cumulatively combined data sets. | Pereira TV et al. | — | 2009 | → |
| Empirical Bayes and semi-Bayes adjustments for a vast number of estimations. | Strömberg U | — | 2009 | → |
| Epidemiologic evidence for chloroprene carcinogenicity: review of study quality and its application to risk assessment. | Bukowski JA | — | 2009 | → |
| Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases. | Khoury MJ et al. | — | 2009 | → |
| Integration of evidence from multiple meta-analyses: a primer on umbrella reviews, treatment networks and multiple treatments meta-analyses. | Ioannidis JP | — | 2009 | → |
| Interpreting epidemiologic studies of developmental neurotoxicity: conceptual and analytic issues. | Bellinger DC | — | 2009 | → |
| Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. | Evangelou E et al. | — | 2009 | → |
| Maternal thyroid disease, thyroid medication use, and selected birth defects in the National Birth Defects Prevention Study. | Browne ML et al. | — | 2009 | → |
| Meta-analysis in genome-wide association studies. | Zeggini E et al. | — | 2009 | → |
| Meta-analysis of genetic association studies: methodologies, between-study heterogeneity and winner's curse. | Nakaoka H et al. | — | 2009 | → |
| Perfluoroalkyl chemicals and human fetal development: an epidemiologic review with clinical and toxicological perspectives. | Olsen GW et al. | — | 2009 | → |
| Polymorphisms in thrombophilia and renin-angiotensin system pathways, preterm delivery, and evidence of placental hemorrhage. | Gargano JW et al. | — | 2009 | → |
| Population-wide generalizability of genome-wide discovered associations. | Ioannidis JP | — | 2009 | → |
| Prediction of cardiovascular disease outcomes and established cardiovascular risk factors by genome-wide association markers. | Ioannidis JP | — | 2009 | → |
| Re: "Neonatal hair nicotine levels and fetal exposure to paternal smoking at home". | Stang A | — | 2009 | → |
| Repeatability of published microarray gene expression analyses. | Ioannidis JP et al. | — | 2009 | → |
| Replication in genome-wide association studies. | Kraft P et al. | — | 2009 | → |
| Replication of genes for asthma: the importance of well-designed studies. | Litonjua AA et al. | — | 2009 | → |
| Reply to Comments on "Puzzlingly High Correlations in fMRI Studies of Emotion, Personality, and Social Cognition". | Vul E et al. | — | 2009 | → |
| STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression. | Cunnington MS et al. | — | 2009 | → |
| Validating, augmenting and refining genome-wide association signals. | Ioannidis JP et al. | — | 2009 | → |
| Whole-genome conditional two-locus analysis identifies novel candidate genes for late-onset Parkinson's disease. | González-Pérez A et al. | — | 2009 | → |
| Why are so many epidemiology associations inflated or wrong? Does poorly conducted animal research suggest implausible hypotheses? | Bracken MB | — | 2009 | → |
| Curses--winner's and otherwise--in genetic epidemiology. | Kraft P | — | 2008 | → |
| Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials? | Ioannidis JP | — | 2008 | → |
| The search for truth must go beyond statistics. | Willett WC | — | 2008 | → |
| Transposed conditionals, shrinkage, and direct and indirect unbiasedness. | Senn S | — | 2008 | → |
| Why current publication practices may distort science. | Young NS et al. | — | 2008 | → |
| Antibiotics for treating acute chest syndrome in people with sickle cell disease. | Martí-Carvajal AJ et al. | — | 2007 | → |