Positive association between PDLIM5 and schizophrenia in the Chinese Han population.
- Authors
- Li, Chao; Tao, Ran; Qin, Wei; Zheng, Yonglan; He, Guang; Shi, Yongyong; Li, Xingwang; Guo, Zhongmeng; Chen, Helong; Feng, Guoyin; He, Lin
- Year
- 2008
- Journal
- The international journal of neuropsychopharmacology
- PMID
- 18021463
- DOI
- 10.1017/S1461145707007687
The PDZ and LIM domain 5 protein (PDLIM5) contains one PDZ (post-synaptic density-95/discs large/zone occludens-1) domain and three LIM (Lin-11, Isl-1, and Mec-3) domains, and is also known as Enigma homologue LIM domain (ENH) protein or LIM protein. DNA microarray analysis of post-mortem brains of schizophrenics has indicated up-regulation of the mRNA level of PDLIM5, and Horiuchi and colleagues reported two single nucleotide polymorphisms (SNPs) (rs2433320 and rs2433322) in the 5' region of the PDZ and LIM domain 5 gene (PDLIM5) to be significantly associated with schizophrenia in the Japanese population. On the other hand, no association with schizophrenia was observed by Kato and colleagues in a different sample of the Japanese population. In this study, we genotyped six SNPs (including rs2433320 and rs2433322) covering PDLIM5 in 507 schizophrenia patients and 530 normal controls recruited from Jiangxi Province, China. Although rs2433320 was negative in our samples, rs2433322 showed significantly different frequencies between cases and controls (P=0.000010). In addition, high linkage disequilibrium was observed between rs2433320 and rs2433322 (D'=0.880), and haplotypes constructed from the two SNPs were significantly associated with schizophrenia (global P=0.00019, even after strict Bonferroni correction). Our results provide further evidence to support PDLIM5 as a potential susceptible gene for schizophrenia.
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External
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|---|---|---|---|---|
| Role of a Pdlim5:PalmD complex in directing dendrite morphology. | Srivastava Y et al. | — | 2024 | → |
| Nicotine pretreatment alleviates MK-801-induced behavioral and cognitive deficits in mice by regulating Pdlim5/CRTC1 in the PFC. | Wang Q et al. | — | 2023 | → |
| “Role of a Pdlim5:PalmD complex in directing dendrite morphology” | Srivastava Y et al. | — | 2023 | — |
| Schizophrenia-derived hiPSC brain microvascular endothelial-like cells show impairments in angiogenesis and blood-brain barrier function. | Casas BS et al. | — | 2022 | → |
| The unexpected versatility of ALP/Enigma family proteins. | Fisher LAB et al. | — | 2022 | → |
| The C. elegans BRCA2-ALP/Enigma Complex Regulates Axon Regeneration via a Rho GTPase-ROCK-MLC Phosphorylation Pathway. | Shimizu T et al. | — | 2018 | → |
| Polymorphisms in PDLIM5 gene are associated with alcohol dependence, type 2 diabetes, and hypertension. | Owusu D et al. | — | 2017 | → |
| Bayesian logistic regression in detection of gene-steroid interaction for cancer at PDLIM5 locus. | Wang KS et al. | — | 2016 | → |
| Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models. | Samsom JN et al. | — | 2015 | → |
| Genetic factors for alcohol dependence and schizophrenia: common and rare variants. | Wang K et al. | — | 2014 | → |
| Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. | Gelernter J et al. | — | 2014 | → |
| Experimental evidence for the involvement of PDLIM5 in mood disorders in hetero knockout mice. | Horiuchi Y et al. | — | 2013 | → |
| A promoter polymorphism in the Per3 gene is associated with alcohol and stress response. | Wang X et al. | — | 2012 | → |
| Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors. | Wong ML et al. | — | 2012 | → |
| Postsynaptic PDLIM5/Enigma Homolog binds SPAR and causes dendritic spine shrinkage. | Herrick S et al. | — | 2010 | → |
| Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms. | Elkins JM et al. | — | 2010 | → |
| PDLIM5 is not a neuronal CaV2.2 adaptor protein. | Gardezi SR et al. | — | 2009 | → |
| Positive association between the PDLIM5 gene and bipolar disorder in the Chinese Han population. | Zhao T et al. | — | 2009 | → |